locus-tag	class	description
HCN54_RS00010	COG3938	Belongs to the proline racemase family
HCN54_RS00020	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HCN54_RS00045	COG2824	Alkylphosphonate utilization operon protein PhnA
HCN54_RS00065	COG0667	Aldo Keto reductase
HCN54_RS00085	COG3279	Response regulator of the LytR AlgR family
HCN54_RS00095	COG3537	Alpha-1,2-mannosidase
HCN54_RS00105	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
HCN54_RS00125	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HCN54_RS00135	COG0363	glucosamine-6-phosphate deaminase activity
HCN54_RS00175	COG1349	DNA-binding transcription factor activity
HCN54_RS00180	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HCN54_RS00185	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HCN54_RS00190	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HCN54_RS00205	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HCN54_RS00210	COG0076	glutamate decarboxylase activity
HCN54_RS00220	COG2814	Major facilitator Superfamily
HCN54_RS00225	COG1621	beta-fructofuranosidase activity
HCN54_RS00230	COG1609	Transcriptional regulator
HCN54_RS00235	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HCN54_RS00240	COG1554	hydrolase, family 65, central catalytic
HCN54_RS00250	COG2095	MarC family integral membrane protein
HCN54_RS00280	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HCN54_RS00285	COG1629	transport
HCN54_RS00290	COG2081	HI0933 family
HCN54_RS00295	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
HCN54_RS00320	COG1187	pseudouridine synthase activity
HCN54_RS00330	COG0010	Belongs to the arginase family
HCN54_RS00335	COG1899	peptidyl-lysine modification to peptidyl-hypusine
HCN54_RS00345	COG0463	Glycosyl transferase, family 2
HCN54_RS00375	COG1215	transferase activity, transferring glycosyl groups
HCN54_RS00380	COG0463	Glycosyl transferase, family 2
HCN54_RS00405	COG0401	homolog of Blt101
HCN54_RS00420	COG1160	GTP binding
HCN54_RS00445	COG1704	LemA family
HCN54_RS00460	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HCN54_RS00485	COG4585	Histidine kinase
HCN54_RS00495	COG2197	response regulator
HCN54_RS00535	COG2515	1-aminocyclopropane-1-carboxylate deaminase
HCN54_RS00540	COG1388	LysM domain
HCN54_RS00540	COG3942	CHAP domain
HCN54_RS00545	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HCN54_RS00555	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HCN54_RS00565	COG0321	lipoyl(octanoyl) transferase activity
HCN54_RS00580	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HCN54_RS00585	COG1629	transport
HCN54_RS00585	COG4206	TonB-dependent receptor
HCN54_RS00590	COG0702	epimerase
HCN54_RS00655	COG0587	DNA-directed DNA polymerase activity
HCN54_RS00660	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HCN54_RS00670	COG3275	phosphorelay sensor kinase activity
HCN54_RS00675	COG1136	(ABC) transporter
HCN54_RS00675	COG0577	efflux transmembrane transporter activity
HCN54_RS00680	COG1136	(ABC) transporter
HCN54_RS00685	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HCN54_RS00705	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HCN54_RS00735	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HCN54_RS00755	COG0823	Involved in the tonB-independent uptake of proteins
HCN54_RS00755	COG1506	peptidase
HCN54_RS00760	COG3104	oligopeptide transport
HCN54_RS00765	COG3104	oligopeptide transport
HCN54_RS00775	COG0658	competence protein
HCN54_RS00775	COG2333	competence protein COMEC
HCN54_RS00780	COG0791	NLP P60 protein
HCN54_RS00790	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HCN54_RS00800	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HCN54_RS00810	COG0772	Belongs to the SEDS family
HCN54_RS00815	COG0768	penicillin binding
HCN54_RS00830	COG1077	Cell shape determining protein MreB Mrl
HCN54_RS00835	COG0138	bifunctional purine biosynthesis protein purh
HCN54_RS00840	COG0577	efflux transmembrane transporter activity
HCN54_RS00865	COG0459	protein refolding
HCN54_RS00870	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HCN54_RS00890	COG3829	transcription factor binding
HCN54_RS00895	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HCN54_RS00900	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HCN54_RS00900	COG1754	DNA topoisomerase type I activity
HCN54_RS00910	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HCN54_RS00930	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HCN54_RS00930	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HCN54_RS00940	COG0488	(ABC) transporter
HCN54_RS00985	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HCN54_RS01000	COG2132	Multicopper oxidase
HCN54_RS01035	COG0069	glutamate synthase activity
HCN54_RS01050	COG0701	Predicted permease
HCN54_RS01060	COG2217	Heavy metal translocating P-type atpase
HCN54_RS01080	COG1475	DNA binding
HCN54_RS01125	COG0629	single-stranded DNA binding
HCN54_RS01130	COG2003	Belongs to the UPF0758 family
HCN54_RS01190	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HCN54_RS01195	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HCN54_RS01210	COG1285	pathogenesis
HCN54_RS01215	COG3781	membrane
HCN54_RS01245	COG0347	Belongs to the P(II) protein family
HCN54_RS01280	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HCN54_RS01285	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HCN54_RS01300	COG0295	cytidine deaminase activity
HCN54_RS01305	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HCN54_RS01310	COG0508	dehydrogenase complex catalyzes the overall conversion of
HCN54_RS01315	COG2234	aminopeptidase activity
HCN54_RS01340	COG1127	ABC transporter
HCN54_RS01345	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HCN54_RS01350	COG1524	type I phosphodiesterase nucleotide pyrophosphatase
HCN54_RS01375	COG1216	Glycosyl transferase, family 2
HCN54_RS01395	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HCN54_RS01395	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HCN54_RS01415	COG0339	signal peptide processing
HCN54_RS01420	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HCN54_RS01425	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HCN54_RS01430	COG0563	adenylate kinase activity
HCN54_RS01435	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HCN54_RS01450	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HCN54_RS01465	COG2003	Belongs to the UPF0758 family
HCN54_RS01495	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HCN54_RS01515	COG4206	TonB-dependent receptor
HCN54_RS01515	COG1629	transport
HCN54_RS01530	COG1629	transport
HCN54_RS01540	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HCN54_RS01545	COG0049	tRNA binding
HCN54_RS01550	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HCN54_RS01555	COG0051	transcription antitermination factor activity, RNA binding
HCN54_RS01560	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HCN54_RS01565	COG0088	Forms part of the polypeptide exit tunnel
HCN54_RS01570	COG0089	rRNA binding
HCN54_RS01575	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HCN54_RS01580	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HCN54_RS01585	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HCN54_RS01590	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HCN54_RS01595	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HCN54_RS01600	COG0255	Belongs to the universal ribosomal protein uL29 family
HCN54_RS01605	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HCN54_RS01610	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HCN54_RS01615	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HCN54_RS01620	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HCN54_RS01625	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HCN54_RS01630	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HCN54_RS01635	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HCN54_RS01640	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HCN54_RS01645	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HCN54_RS01650	COG1841	ribosomal large subunit assembly
HCN54_RS01655	COG0200	Binds to the 23S rRNA
HCN54_RS01665	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HCN54_RS01670	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HCN54_RS01675	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HCN54_RS01680	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HCN54_RS01685	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HCN54_RS01690	COG0202	RNA polymerase activity
HCN54_RS01695	COG0203	ribosomal protein L17
HCN54_RS01705	COG0505	Belongs to the CarA family
HCN54_RS01710	COG0148	phosphopyruvate hydratase activity
HCN54_RS01730	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HCN54_RS01735	COG1090	epimerase
HCN54_RS01745	COG0018	arginyl-trna synthetase
HCN54_RS01770	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HCN54_RS01775	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HCN54_RS01805	COG1187	pseudouridine synthase activity
HCN54_RS01830	COG0433	COG0433 Predicted ATPase
HCN54_RS01835	COG0602	queuosine metabolic process
HCN54_RS01845	COG0367	asparagine synthase
HCN54_RS01850	COG0187	DNA topoisomerase II activity
HCN54_RS01860	COG0039	L-malate dehydrogenase activity
HCN54_RS01865	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HCN54_RS01870	COG2066	Belongs to the glutaminase family
HCN54_RS01885	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HCN54_RS01890	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HCN54_RS01895	COG0215	cysteine-tRNA ligase activity
HCN54_RS01900	COG0302	gtp cyclohydrolase
HCN54_RS01915	COG0442	prolyl-tRNA aminoacylation
HCN54_RS01930	COG0268	Binds directly to 16S ribosomal RNA
HCN54_RS01950	COG0101	tRNA pseudouridine synthase activity
HCN54_RS01955	COG1132	(ABC) transporter
HCN54_RS01965	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HCN54_RS01985	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HCN54_RS01990	COG2363	Small membrane protein
HCN54_RS02005	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HCN54_RS02010	COG0352	thiamine-phosphate diphosphorylase activity
HCN54_RS02010	COG0351	phosphomethylpyrimidine kinase
HCN54_RS02015	COG0352	thiamine-phosphate diphosphorylase activity
HCN54_RS02020	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
HCN54_RS02030	COG3250	beta-galactosidase activity
HCN54_RS02060	COG2264	protein methyltransferase activity
HCN54_RS02065	COG0149	triose-phosphate isomerase activity
HCN54_RS02070	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HCN54_RS02090	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HCN54_RS02100	COG0174	glutamine synthetase
HCN54_RS02140	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HCN54_RS02180	COG4771	TonB-dependent receptor
HCN54_RS02195	COG0702	epimerase
HCN54_RS02200	COG4771	TonB-dependent receptor
HCN54_RS02210	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HCN54_RS02220	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
HCN54_RS02225	COG1028	Short-chain dehydrogenase reductase Sdr
HCN54_RS02230	COG1904	glucuronate isomerase
HCN54_RS02240	COG0800	Aldolase
HCN54_RS02245	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HCN54_RS02250	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HCN54_RS02260	COG0246	Mannitol dehydrogenase
HCN54_RS02265	COG2721	sulfolactate sulfo-lyase activity
HCN54_RS02270	COG1609	Transcriptional regulator
HCN54_RS02280	COG4771	TonB-dependent receptor
HCN54_RS02295	COG2755	lipolytic protein G-D-S-L family
HCN54_RS02300	COG1028	Short-chain dehydrogenase reductase Sdr
HCN54_RS02305	COG1312	Catalyzes the dehydration of D-mannonate
HCN54_RS02350	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
HCN54_RS02355	COG1252	NADH dehydrogenase
HCN54_RS02375	COG0471	metal ion transport
HCN54_RS02380	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HCN54_RS02385	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HCN54_RS02390	COG2205	protein histidine kinase activity
HCN54_RS02390	COG0784	Response regulator, receiver
HCN54_RS02395	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HCN54_RS02400	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HCN54_RS02405	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HCN54_RS02410	COG1185	polyribonucleotide nucleotidyltransferase activity
HCN54_RS02415	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HCN54_RS02420	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HCN54_RS02425	COG0191	fructose-bisphosphate aldolase activity
HCN54_RS02435	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HCN54_RS02440	COG4106	trans-aconitate 2-methyltransferase activity
HCN54_RS02450	COG2226	methyltransferase
HCN54_RS02455	COG0569	domain protein
HCN54_RS02465	COG0492	ferredoxin-NADP+ reductase activity
HCN54_RS02470	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HCN54_RS02475	COG0436	Aminotransferase
HCN54_RS02480	COG3239	Fatty acid desaturase
HCN54_RS02485	COG0357	Ribosomal RNA small subunit methyltransferase G
HCN54_RS02495	COG1012	belongs to the aldehyde dehydrogenase family
HCN54_RS02515	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HCN54_RS02520	COG1805	sodium ion transport
HCN54_RS02525	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HCN54_RS02530	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HCN54_RS02535	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HCN54_RS02550	COG1477	protein flavinylation
HCN54_RS02560	COG2226	methyltransferase
HCN54_RS02600	COG3118	belongs to the thioredoxin family
HCN54_RS02605	COG0702	epimerase
HCN54_RS02630	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HCN54_RS02635	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HCN54_RS02645	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HCN54_RS02660	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HCN54_RS02665	COG3959	Transketolase, thiamine diphosphate binding domain
HCN54_RS02670	COG0343	queuine tRNA-ribosyltransferase activity
HCN54_RS02685	COG0825	malonyl-CoA metabolic process
HCN54_RS02690	COG0305	Participates in initiation and elongation during chromosome replication
HCN54_RS02710	COG0009	L-threonylcarbamoyladenylate synthase
HCN54_RS02715	COG1360	Flagellar Motor Protein
HCN54_RS02740	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HCN54_RS02750	COG0205	6-phosphofructokinase activity
HCN54_RS02765	COG0251	oxidation-reduction process
HCN54_RS02775	COG0860	N-Acetylmuramoyl-L-alanine amidase
HCN54_RS02785	COG0247	lactate metabolic process
HCN54_RS02785	COG2181	nitrate reductase activity
HCN54_RS02795	COG0247	lactate metabolic process
HCN54_RS02795	COG2181	nitrate reductase activity
HCN54_RS02805	COG1472	Belongs to the glycosyl hydrolase 3 family
HCN54_RS02810	COG0438	transferase activity, transferring glycosyl groups
HCN54_RS02820	COG0277	FAD linked oxidase domain protein
HCN54_RS02820	COG0247	lactate metabolic process
HCN54_RS02835	COG1764	response to oxidative stress
HCN54_RS02840	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HCN54_RS02845	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HCN54_RS02850	COG1086	Polysaccharide biosynthesis protein
HCN54_RS02865	COG4771	TonB-dependent receptor
HCN54_RS02870	COG0702	epimerase
HCN54_RS02895	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
HCN54_RS02920	COG0312	modulator of DNA gyrase
HCN54_RS02930	COG0714	Associated with various cellular activities
HCN54_RS02975	COG2217	Heavy metal translocating P-type atpase
HCN54_RS02990	COG1131	(ABC) transporter
HCN54_RS03025	COG1401	restriction endodeoxyribonuclease activity
HCN54_RS03060	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HCN54_RS03065	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
HCN54_RS03120	COG2195	Cleaves the N-terminal amino acid of tripeptides
HCN54_RS03130	COG4771	TonB-dependent receptor
HCN54_RS03135	COG2205	protein histidine kinase activity
HCN54_RS03135	COG0745	RESPONSE REGULATOR receiver
HCN54_RS03135	COG3292	Two component regulator propeller
HCN54_RS03140	COG4771	TonB-dependent receptor
HCN54_RS03195	COG4974	Belongs to the 'phage' integrase family
HCN54_RS03205	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HCN54_RS03215	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HCN54_RS03260	COG0300	oxidoreductase activity
HCN54_RS03265	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HCN54_RS03275	COG0488	(ABC) transporter
HCN54_RS03295	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HCN54_RS03320	COG3263	regulation of cellular component size
HCN54_RS03335	COG0069	glutamate synthase activity
HCN54_RS03340	COG1473	amidohydrolase
HCN54_RS03365	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HCN54_RS03370	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HCN54_RS03375	COG1301	dicarboxylic acid transport
HCN54_RS03390	COG4771	TonB-dependent receptor
HCN54_RS03395	COG3011	Protein conserved in bacteria
HCN54_RS03405	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HCN54_RS03420	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HCN54_RS03445	COG0022	dehydrogenase e1 component
HCN54_RS03460	COG1360	Flagellar Motor Protein
HCN54_RS03465	COG0492	ferredoxin-NADP+ reductase activity
HCN54_RS03475	COG3424	synthase
HCN54_RS03480	COG1028	Short-chain dehydrogenase reductase Sdr
HCN54_RS03495	COG2307	Protein conserved in bacteria
HCN54_RS03495	COG2308	Evidence 4 Homologs of previously reported genes of
HCN54_RS03525	COG2115	Belongs to the xylose isomerase family
HCN54_RS03550	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HCN54_RS03570	COG1785	Belongs to the alkaline phosphatase family
HCN54_RS03585	COG1136	(ABC) transporter
HCN54_RS03610	COG0523	cobalamin synthesis protein
HCN54_RS03620	COG0302	gtp cyclohydrolase
HCN54_RS03635	COG1629	transport
HCN54_RS03635	COG4206	TonB-dependent receptor
HCN54_RS03665	COG4977	sequence-specific DNA binding
HCN54_RS03665	COG1917	Cupin 2, conserved barrel domain protein
HCN54_RS03990	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HCN54_RS04035	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HCN54_RS04040	COG1678	Uncharacterized ACR, COG1678
HCN54_RS04050	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HCN54_RS04055	COG0514	ATP-dependent DNA helicase (RecQ)
HCN54_RS04075	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HCN54_RS04080	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
HCN54_RS04090	COG1129	ABC transporter
HCN54_RS04105	COG0415	Belongs to the DNA photolyase family
HCN54_RS04110	COG1028	Short-chain dehydrogenase reductase Sdr
HCN54_RS04125	COG0673	inositol 2-dehydrogenase activity
HCN54_RS04130	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HCN54_RS04140	COG0424	maF-like protein
HCN54_RS04190	COG0583	DNA-binding transcription factor activity
HCN54_RS04225	COG1272	protein, Hemolysin III
HCN54_RS04240	COG0116	Belongs to the methyltransferase superfamily
HCN54_RS04245	COG0791	NLP P60 protein
HCN54_RS04250	COG0183	Belongs to the thiolase family
HCN54_RS04270	COG0784	Response regulator, receiver
HCN54_RS04280	COG4251	negative regulation of phosphorylation
HCN54_RS04290	COG2205	protein histidine kinase activity
HCN54_RS04300	COG3279	Response regulator of the LytR AlgR family
HCN54_RS04350	COG0463	Glycosyl transferase, family 2
HCN54_RS04355	COG3279	Response regulator of the LytR AlgR family
HCN54_RS04385	COG1028	Short-chain dehydrogenase reductase Sdr
HCN54_RS04390	COG0693	protein deglycase activity
HCN54_RS04390	COG0753	catalase activity
HCN54_RS04405	COG4095	Psort location CytoplasmicMembrane, score
HCN54_RS04420	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HCN54_RS04425	COG2323	membrane
HCN54_RS04440	COG0629	single-stranded DNA binding
HCN54_RS04450	COG2003	Belongs to the UPF0758 family
HCN54_RS04465	COG0582	viral genome integration into host DNA
HCN54_RS04475	COG2949	membrane
HCN54_RS04480	COG0778	Nitroreductase
HCN54_RS04490	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HCN54_RS04490	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HCN54_RS04505	COG1674	ftsk spoiiie
HCN54_RS04515	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HCN54_RS04525	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HCN54_RS04530	COG0450	alkyl hydroperoxide reductase
HCN54_RS04545	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HCN54_RS04555	COG1119	ATPase activity
HCN54_RS04570	COG0745	RESPONSE REGULATOR receiver
HCN54_RS04595	COG0701	Predicted permease
HCN54_RS04605	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HCN54_RS04610	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HCN54_RS04620	COG4251	negative regulation of phosphorylation
HCN54_RS04625	COG0745	RESPONSE REGULATOR receiver
HCN54_RS04645	COG0628	permease
HCN54_RS04670	COG0045	succinate-CoA ligase (ADP-forming) activity
HCN54_RS04680	COG0071	Belongs to the small heat shock protein (HSP20) family
HCN54_RS04685	COG4974	Belongs to the 'phage' integrase family
HCN54_RS04700	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HCN54_RS04710	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HCN54_RS04715	COG1573	uracil-dna glycosylase
HCN54_RS04725	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HCN54_RS04735	COG0366	Alpha amylase catalytic
HCN54_RS04740	COG3281	Trehalose synthase
HCN54_RS04745	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HCN54_RS04760	COG2270	Major facilitator Superfamily
HCN54_RS04785	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HCN54_RS04795	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HCN54_RS04800	COG2814	Major facilitator Superfamily
HCN54_RS04805	COG1012	belongs to the aldehyde dehydrogenase family
HCN54_RS04810	COG1473	amidohydrolase
HCN54_RS04825	COG0539	negative regulation of cytoplasmic translation
HCN54_RS04835	COG2814	Major facilitator Superfamily
HCN54_RS04865	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HCN54_RS04895	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HCN54_RS04900	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HCN54_RS04910	COG1607	acyl-coa hydrolase
HCN54_RS04920	COG1322	Protein conserved in bacteria
HCN54_RS04925	COG1120	ATPase activity
HCN54_RS04930	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HCN54_RS04960	COG1595	DNA-templated transcription, initiation
HCN54_RS04980	COG0280	phosphate acetyltransferase
HCN54_RS04980	COG0857	belongs to the CobB CobQ family
HCN54_RS04985	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HCN54_RS05005	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HCN54_RS05035	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HCN54_RS05045	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HCN54_RS05055	COG1733	regulation of RNA biosynthetic process
HCN54_RS05065	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HCN54_RS05065	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HCN54_RS05080	COG3275	phosphorelay sensor kinase activity
HCN54_RS05095	COG3279	Response regulator of the LytR AlgR family
HCN54_RS05115	COG1595	DNA-templated transcription, initiation
HCN54_RS05125	COG1597	lipid kinase activity
HCN54_RS05140	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HCN54_RS05155	COG2885	chlorophyll binding
HCN54_RS05180	COG0561	phosphatase activity
HCN54_RS05190	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HCN54_RS05195	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HCN54_RS05200	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HCN54_RS05205	COG0363	glucosamine-6-phosphate deaminase activity
HCN54_RS05210	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HCN54_RS05225	COG4771	TonB-dependent receptor
HCN54_RS05235	COG3292	Two component regulator propeller
HCN54_RS05235	COG2205	protein histidine kinase activity
HCN54_RS05235	COG0745	RESPONSE REGULATOR receiver
HCN54_RS05245	COG3250	beta-galactosidase activity
HCN54_RS05250	COG4948	Mandelate Racemase Muconate Lactonizing
HCN54_RS05270	COG3250	beta-galactosidase activity
HCN54_RS05275	COG4989	oxidoreductase activity
HCN54_RS05295	COG1960	acyl-CoA dehydrogenase activity
HCN54_RS05305	COG0183	Belongs to the thiolase family
HCN54_RS05310	COG1250	3-hydroxyacyl-CoA dehydrogenase
HCN54_RS05310	COG1024	Enoyl-CoA hydratase
HCN54_RS05320	COG1022	Amp-dependent synthetase and ligase
HCN54_RS05350	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HCN54_RS05350	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HCN54_RS05375	COG1132	(ABC) transporter
HCN54_RS05380	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HCN54_RS05395	COG0254	rRNA binding
HCN54_RS05405	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HCN54_RS05425	COG0335	large ribosomal subunit rRNA binding
HCN54_RS05430	COG0336	Belongs to the RNA methyltransferase TrmD family
HCN54_RS05445	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HCN54_RS05450	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HCN54_RS05460	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HCN54_RS05470	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HCN54_RS05475	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HCN54_RS05480	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HCN54_RS05495	COG0697	spore germination
HCN54_RS05500	COG1011	Hydrolase
HCN54_RS05505	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HCN54_RS05505	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HCN54_RS05515	COG2890	protein-(glutamine-N5) methyltransferase activity
HCN54_RS05530	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HCN54_RS05545	COG0737	Belongs to the 5'-nucleotidase family
HCN54_RS05550	COG0737	Belongs to the 5'-nucleotidase family
HCN54_RS05560	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HCN54_RS05585	COG0497	DNA recombination
HCN54_RS05590	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HCN54_RS05595	COG1442	glycosyl transferase family 8
HCN54_RS05595	COG1216	Glycosyl transferase, family 2
HCN54_RS05605	COG0237	dephospho-CoA kinase activity
HCN54_RS05620	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HCN54_RS05625	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HCN54_RS05635	COG2176	DNA-directed DNA polymerase activity
HCN54_RS05640	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HCN54_RS05655	COG1250	3-hydroxyacyl-CoA dehydrogenase
HCN54_RS05665	COG1702	phosphate starvation-inducible protein PhoH
HCN54_RS05670	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HCN54_RS05675	COG1115	amino acid carrier protein
HCN54_RS05690	COG4753	response regulator
HCN54_RS05690	COG2207	Transcriptional regulator
HCN54_RS05700	COG3118	belongs to the thioredoxin family
HCN54_RS05740	COG1331	Highly conserved protein containing a thioredoxin domain
HCN54_RS05745	COG2080	2 iron, 2 sulfur cluster binding
HCN54_RS05750	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HCN54_RS05755	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HCN54_RS05760	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HCN54_RS05765	COG3387	PFAM Glycoside hydrolase 15-related
HCN54_RS05770	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HCN54_RS05775	COG3940	Belongs to the glycosyl hydrolase 43 family
HCN54_RS05780	COG2814	Major facilitator Superfamily
HCN54_RS05795	COG1132	(ABC) transporter
HCN54_RS05800	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HCN54_RS05810	COG1862	Preprotein translocase
HCN54_RS05830	COG2814	Major facilitator Superfamily
HCN54_RS05840	COG1028	Short-chain dehydrogenase reductase Sdr
HCN54_RS05880	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HCN54_RS05885	COG0471	metal ion transport
HCN54_RS05885	COG3273	potassium ion transport
HCN54_RS05895	COG4221	oxidoreductase activity
HCN54_RS05915	COG1047	Peptidyl-prolyl cis-trans
HCN54_RS05925	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HCN54_RS05935	COG1475	DNA binding
HCN54_RS05940	COG1192	Involved in chromosome partitioning
HCN54_RS05945	COG1028	Short-chain dehydrogenase reductase Sdr
HCN54_RS05950	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HCN54_RS05950	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HCN54_RS05955	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HCN54_RS05965	COG0572	uridine kinase
HCN54_RS05980	COG1082	Xylose isomerase domain protein TIM barrel
HCN54_RS06000	COG1222	aaa ATPase
HCN54_RS06110	COG2197	response regulator
HCN54_RS06130	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HCN54_RS06150	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HCN54_RS06160	COG0217	transcriptional regulatory protein
HCN54_RS06170	COG0297	glycogen (starch) synthase activity
HCN54_RS06175	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HCN54_RS06180	COG0315	cyclic pyranopterin monophosphate synthase activity
HCN54_RS06190	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HCN54_RS06200	COG0746	molybdenum cofactor guanylyltransferase activity
HCN54_RS06210	COG0303	'Molybdopterin
HCN54_RS06225	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HCN54_RS06250	COG2223	nitrite transmembrane transporter activity
HCN54_RS06255	COG0243	molybdopterin cofactor binding
HCN54_RS06265	COG1648	precorrin-2 dehydrogenase activity
HCN54_RS06265	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HCN54_RS06290	COG2133	pyrroloquinoline quinone binding
HCN54_RS06295	COG0492	ferredoxin-NADP+ reductase activity
HCN54_RS06305	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HCN54_RS06320	COG0686	Belongs to the AlaDH PNT family
HCN54_RS06335	COG0802	atpase or kinase
HCN54_RS06340	COG2204	response regulator
HCN54_RS06345	COG1078	dGTPase activity
HCN54_RS06350	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HCN54_RS06355	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HCN54_RS06355	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HCN54_RS06360	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HCN54_RS06365	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HCN54_RS06380	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HCN54_RS06385	COG1028	Short-chain dehydrogenase reductase Sdr
HCN54_RS06410	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HCN54_RS06415	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HCN54_RS06420	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HCN54_RS06425	COG0131	Imidazoleglycerol-phosphate dehydratase
HCN54_RS06430	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HCN54_RS06435	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HCN54_RS06445	COG0107	imidazoleglycerol-phosphate synthase activity
HCN54_RS06450	COG0140	phosphoribosyl-ATP diphosphatase activity
HCN54_RS06450	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HCN54_RS06460	COG0514	ATP-dependent DNA helicase (RecQ)
HCN54_RS06475	COG0513	Belongs to the DEAD box helicase family
HCN54_RS06515	COG1064	alcohol dehydrogenase
HCN54_RS06530	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
HCN54_RS06560	COG4447	cellulose binding
HCN54_RS06575	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HCN54_RS06585	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HCN54_RS06600	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HCN54_RS06625	COG0590	tRNA wobble adenosine to inosine editing
HCN54_RS06645	COG2116	formate transmembrane transporter activity
HCN54_RS06650	COG0590	tRNA wobble adenosine to inosine editing
HCN54_RS06655	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HCN54_RS06685	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HCN54_RS06690	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HCN54_RS06695	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HCN54_RS06705	COG2308	Evidence 4 Homologs of previously reported genes of
HCN54_RS06720	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HCN54_RS06725	COG1393	Belongs to the ArsC family
HCN54_RS06745	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HCN54_RS06745	COG1333	cytochrome c biogenesis protein
HCN54_RS06755	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HCN54_RS06760	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HCN54_RS06780	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HCN54_RS06785	COG1522	sequence-specific DNA binding
HCN54_RS06805	COG3275	phosphorelay sensor kinase activity
HCN54_RS06810	COG0784	Response regulator, receiver
HCN54_RS06810	COG5002	protein histidine kinase activity
HCN54_RS06810	COG2198	Histidine kinase
HCN54_RS06815	COG1970	mechanosensitive ion channel activity
HCN54_RS06840	COG0598	Magnesium transport protein CorA
HCN54_RS06845	COG0693	protein deglycase activity
HCN54_RS06850	COG0101	tRNA pseudouridine synthase activity
HCN54_RS06855	COG1045	serine acetyltransferase
HCN54_RS06900	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HCN54_RS06930	COG0671	phosphoesterase, PA-phosphatase related
HCN54_RS06965	COG0784	Response regulator, receiver
HCN54_RS06965	COG2205	protein histidine kinase activity
HCN54_RS06990	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HCN54_RS07000	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HCN54_RS07010	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HCN54_RS07025	COG0105	UTP biosynthetic process
HCN54_RS07035	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HCN54_RS07045	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HCN54_RS07055	COG2195	Cleaves the N-terminal amino acid of tripeptides
HCN54_RS07060	COG2154	pterin-4-alpha-carbinolamine dehydratase
HCN54_RS07065	COG0217	transcriptional regulatory protein
HCN54_RS07070	COG1418	mRNA catabolic process
HCN54_RS07100	COG1104	cysteine desulfurase activity
HCN54_RS07125	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HCN54_RS07130	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HCN54_RS07135	COG1914	H( )-stimulated, divalent metal cation uptake system
HCN54_RS07140	COG0612	Peptidase, M16
HCN54_RS07145	COG0606	chelatase, subunit chli
HCN54_RS07155	COG1523	belongs to the glycosyl hydrolase 13 family
HCN54_RS07170	COG0037	tRNA processing
HCN54_RS07195	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HCN54_RS07205	COG1271	oxidase subunit
HCN54_RS07210	COG1294	oxidase, subunit
HCN54_RS07220	COG2205	protein histidine kinase activity
HCN54_RS07220	COG3292	Two component regulator propeller
HCN54_RS07220	COG0745	RESPONSE REGULATOR receiver
HCN54_RS07245	COG1629	transport
HCN54_RS07255	COG0745	RESPONSE REGULATOR receiver
HCN54_RS07255	COG3292	Two component regulator propeller
HCN54_RS07255	COG2205	protein histidine kinase activity
HCN54_RS07260	COG0702	epimerase
HCN54_RS07290	COG0629	single-stranded DNA binding
HCN54_RS07300	COG1309	transcriptional regulator
HCN54_RS07310	COG4206	TonB-dependent receptor
HCN54_RS07310	COG1629	transport
HCN54_RS07320	COG4974	Belongs to the 'phage' integrase family
HCN54_RS07355	COG0668	transmembrane transport
HCN54_RS07365	COG2610	gluconate transmembrane transporter activity
HCN54_RS07370	COG3265	gluconokinase activity
HCN54_RS07390	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HCN54_RS07410	COG0592	DNA-directed DNA polymerase activity
HCN54_RS07435	COG0069	glutamate synthase activity
HCN54_RS07435	COG0070	glutamate synthase
HCN54_RS07435	COG0067	glutamate synthase
HCN54_RS07450	COG0004	ammonium transporteR
HCN54_RS07500	COG0705	Rhomboid family
HCN54_RS07510	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HCN54_RS07520	COG0405	Gamma-glutamyltransferase
HCN54_RS07540	COG4181	ATPase activity
HCN54_RS07575	COG1252	NADH dehydrogenase
HCN54_RS07580	COG1595	DNA-templated transcription, initiation
HCN54_RS07610	COG0386	Belongs to the glutathione peroxidase family
HCN54_RS07615	COG1846	Transcriptional regulator
HCN54_RS07640	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HCN54_RS07680	COG0714	Associated with various cellular activities
HCN54_RS07690	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HCN54_RS07695	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HCN54_RS07700	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HCN54_RS07705	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HCN54_RS07715	COG3942	CHAP domain
HCN54_RS07715	COG1388	LysM domain
HCN54_RS07720	COG0519	Catalyzes the synthesis of GMP from XMP
HCN54_RS07720	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HCN54_RS07735	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HCN54_RS07740	COG0714	Associated with various cellular activities
HCN54_RS07745	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HCN54_RS07765	COG0516	GMP reductase activity
HCN54_RS07765	COG0517	IMP dehydrogenase activity
HCN54_RS07775	COG5002	protein histidine kinase activity
HCN54_RS07780	COG0167	dihydroorotate dehydrogenase activity
HCN54_RS07785	COG2195	Cleaves the N-terminal amino acid of tripeptides
HCN54_RS07790	COG0545	Peptidyl-prolyl cis-trans isomerase
HCN54_RS07795	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HCN54_RS07800	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HCN54_RS07820	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HCN54_RS07825	COG0501	Belongs to the peptidase M48B family
HCN54_RS07830	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HCN54_RS07840	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HCN54_RS07860	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HCN54_RS07900	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HCN54_RS07910	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HCN54_RS07935	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HCN54_RS07960	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HCN54_RS07970	COG0259	pyridoxamine-phosphate oxidase activity
HCN54_RS07975	COG1234	tRNA 3'-trailer cleavage
HCN54_RS07985	COG0540	Belongs to the ATCase OTCase family
HCN54_RS07990	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HCN54_RS08005	COG1363	Peptidase, m42
HCN54_RS08015	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HCN54_RS08020	COG1611	Belongs to the LOG family
HCN54_RS08050	COG2996	Protein conserved in bacteria
HCN54_RS08060	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HCN54_RS08065	COG1169	isochorismate synthase
HCN54_RS08095	COG0443	Heat shock 70 kDa protein
HCN54_RS08105	COG1760	l-serine dehydratase
HCN54_RS08120	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HCN54_RS08125	COG0564	pseudouridine synthase activity
HCN54_RS08145	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HCN54_RS08150	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HCN54_RS08155	COG0066	3-isopropylmalate dehydratase activity
HCN54_RS08170	COG1538	Outer membrane efflux protein
HCN54_RS08190	COG0165	Argininosuccinate lyase
HCN54_RS08195	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HCN54_RS08200	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HCN54_RS08210	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HCN54_RS08220	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HCN54_RS08225	COG0137	argininosuccinate synthase activity
HCN54_RS08240	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HCN54_RS08245	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HCN54_RS08250	COG0440	acetolactate synthase activity
HCN54_RS08255	COG0028	Belongs to the TPP enzyme family
HCN54_RS08260	COG0129	dihydroxy-acid dehydratase activity
HCN54_RS08265	COG0667	Aldo Keto reductase
HCN54_RS08280	COG1012	belongs to the aldehyde dehydrogenase family
HCN54_RS08290	COG0012	GTP binding
HCN54_RS08295	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HCN54_RS08305	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HCN54_RS08310	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HCN54_RS08330	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HCN54_RS08330	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HCN54_RS08340	COG0083	homoserine kinase activity
HCN54_RS08345	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HCN54_RS08350	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HCN54_RS08365	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HCN54_RS08385	COG0542	response to heat
HCN54_RS08400	COG0302	gtp cyclohydrolase
HCN54_RS08405	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HCN54_RS08410	COG1136	(ABC) transporter
HCN54_RS08420	COG2205	protein histidine kinase activity
HCN54_RS08465	COG0124	histidyl-tRNA synthetase
HCN54_RS08480	COG0359	binds to the 23S rRNA
HCN54_RS08485	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HCN54_RS08490	COG0360	Binds together with S18 to 16S ribosomal RNA
HCN54_RS08495	COG3279	Response regulator of the LytR AlgR family
HCN54_RS08500	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HCN54_RS08510	COG1295	ribonuclease BN
HCN54_RS08515	COG0157	Belongs to the NadC ModD family
HCN54_RS08520	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HCN54_RS08535	COG3956	TIGRFAM MazG family protein
HCN54_RS08545	COG0242	peptide deformylase activity
HCN54_RS08550	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HCN54_RS08555	COG2171	N-acyltransferase activity
HCN54_RS08570	COG0463	Glycosyl transferase, family 2
HCN54_RS08590	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HCN54_RS08590	COG0517	IMP dehydrogenase activity
HCN54_RS08590	COG0617	tRNA 3'-terminal CCA addition
HCN54_RS08595	COG1612	heme a metabolic process
HCN54_RS08610	COG0556	nucleotide-excision repair
HCN54_RS08625	COG1131	(ABC) transporter
HCN54_RS08645	COG3387	PFAM Glycoside hydrolase 15-related
HCN54_RS08650	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
HCN54_RS08675	COG2160	L-arabinose isomerase activity
HCN54_RS08680	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HCN54_RS08705	COG3507	Belongs to the glycosyl hydrolase 43 family
HCN54_RS08710	COG3507	Belongs to the glycosyl hydrolase 43 family
HCN54_RS08720	COG3534	alpha-L-arabinofuranosidase
HCN54_RS08730	COG0702	epimerase
HCN54_RS08735	COG4771	TonB-dependent receptor
HCN54_RS08750	COG1233	COG1233 Phytoene dehydrogenase and related
HCN54_RS08770	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
HCN54_RS08785	COG0612	Peptidase, M16
HCN54_RS08800	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HCN54_RS08810	COG0154	amidase activity
HCN54_RS08815	COG0552	protein localization to endoplasmic reticulum
HCN54_RS08825	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HCN54_RS08830	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HCN54_RS08835	COG1546	Belongs to the CinA family
HCN54_RS08835	COG1058	Belongs to the CinA family
HCN54_RS08855	COG5002	protein histidine kinase activity
HCN54_RS08855	COG2176	DNA-directed DNA polymerase activity
HCN54_RS08865	COG0508	dehydrogenase complex catalyzes the overall conversion of
HCN54_RS08875	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HCN54_RS08880	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HCN54_RS08885	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HCN54_RS08890	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HCN54_RS08895	COG0783	Belongs to the Dps family
HCN54_RS08900	COG0668	transmembrane transport
HCN54_RS08915	COG3153	acetyltransferase
HCN54_RS08915	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HCN54_RS08935	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HCN54_RS08950	COG4771	TonB-dependent receptor
HCN54_RS08955	COG0156	8-amino-7-oxononanoate synthase activity
HCN54_RS08970	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HCN54_RS08980	COG0346	lactoylglutathione lyase activity
HCN54_RS08990	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HCN54_RS09025	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HCN54_RS09040	COG2267	carboxylic ester hydrolase activity
HCN54_RS09060	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HCN54_RS09080	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HCN54_RS09135	COG2249	NAD(P)H dehydrogenase (quinone) activity
HCN54_RS09140	COG0583	DNA-binding transcription factor activity
HCN54_RS09150	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HCN54_RS09155	COG3507	Belongs to the glycosyl hydrolase 43 family
HCN54_RS09170	COG0513	Belongs to the DEAD box helicase family
HCN54_RS09185	COG4946	Tricorn protease homolog
HCN54_RS09185	COG0793	Belongs to the peptidase S41A family
HCN54_RS09210	COG0662	Cupin 2, conserved barrel domain protein
HCN54_RS09210	COG2207	Transcriptional regulator
HCN54_RS09235	COG1764	response to oxidative stress
HCN54_RS09240	COG1703	isobutyryl-CoA mutase activity
HCN54_RS09250	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HCN54_RS09255	COG0671	phosphoesterase, PA-phosphatase related
HCN54_RS09265	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HCN54_RS09280	COG3118	belongs to the thioredoxin family
HCN54_RS09285	COG0542	response to heat
HCN54_RS09320	COG4774	siderophore transport
HCN54_RS09355	COG0420	3'-5' exonuclease activity
HCN54_RS09360	COG0419	ATPase involved in DNA repair
HCN54_RS09365	COG1607	acyl-coa hydrolase
HCN54_RS09370	COG0006	proline dipeptidase activity
HCN54_RS09390	COG1858	cytochrome C peroxidase
HCN54_RS09400	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HCN54_RS09405	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HCN54_RS09420	COG2234	aminopeptidase activity
HCN54_RS09440	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HCN54_RS09445	COG0626	cystathionine gamma-synthase activity
HCN54_RS09455	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HCN54_RS09465	COG2249	NAD(P)H dehydrogenase (quinone) activity
HCN54_RS09475	COG2706	6-phosphogluconolactonase activity
HCN54_RS09485	COG2855	membrane
HCN54_RS09510	COG2884	Cell division ATP-binding protein ftsE
HCN54_RS09525	COG1216	Glycosyl transferase, family 2
HCN54_RS09525	COG0463	Glycosyl transferase, family 2
HCN54_RS09535	COG0438	transferase activity, transferring glycosyl groups
HCN54_RS09575	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HCN54_RS09580	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HCN54_RS09620	COG4452	Inner membrane protein CreD
HCN54_RS09665	COG0673	inositol 2-dehydrogenase activity
HCN54_RS09690	COG0702	epimerase
HCN54_RS09695	COG1629	transport
HCN54_RS09710	COG1858	cytochrome C peroxidase
HCN54_RS09725	COG1629	transport
HCN54_RS09755	COG1401	restriction endodeoxyribonuclease activity
HCN54_RS09810	COG4447	cellulose binding
HCN54_RS09835	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HCN54_RS09850	COG2354	Protein conserved in bacteria
HCN54_RS09870	COG5002	protein histidine kinase activity
HCN54_RS10015	COG2369	cell adhesion
HCN54_RS10105	COG1199	ATP-dependent helicase activity
HCN54_RS10105	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HCN54_RS10120	COG4771	TonB-dependent receptor
HCN54_RS10125	COG0561	phosphatase activity
HCN54_RS10145	COG1629	transport
HCN54_RS10160	COG3537	Alpha-1,2-mannosidase
HCN54_RS10165	COG0673	inositol 2-dehydrogenase activity
HCN54_RS10185	COG3537	Alpha-1,2-mannosidase
HCN54_RS10195	COG1940	carbohydrate kinase activity
HCN54_RS10220	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HCN54_RS10225	COG4771	TonB-dependent receptor
HCN54_RS10240	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HCN54_RS10250	COG1522	sequence-specific DNA binding
HCN54_RS10255	COG0673	inositol 2-dehydrogenase activity
HCN54_RS10275	COG0738	Major facilitator superfamily
HCN54_RS10280	COG3408	Glycogen debranching enzyme
HCN54_RS10295	COG3250	beta-galactosidase activity
HCN54_RS10300	COG0745	RESPONSE REGULATOR receiver
HCN54_RS10300	COG2205	protein histidine kinase activity
HCN54_RS10300	COG3292	Two component regulator propeller
HCN54_RS10305	COG2755	lipolytic protein G-D-S-L family
HCN54_RS10310	COG3250	beta-galactosidase activity
HCN54_RS10315	COG2755	lipolytic protein G-D-S-L family
HCN54_RS10320	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HCN54_RS10325	COG1028	Short-chain dehydrogenase reductase Sdr
HCN54_RS10325	COG3347	Dehydrogenase
HCN54_RS10330	COG4952	isomerase
HCN54_RS10335	COG1070	Carbohydrate kinase
HCN54_RS10340	COG1304	FMN binding
HCN54_RS10370	COG3401	FG-GAP repeat protein
HCN54_RS10390	COG2755	lipolytic protein G-D-S-L family
HCN54_RS10390	COG0657	acetylesterase activity
HCN54_RS10395	COG3250	beta-galactosidase activity
HCN54_RS10400	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HCN54_RS10410	COG4771	TonB-dependent receptor
HCN54_RS10420	COG0784	Response regulator, receiver
HCN54_RS10420	COG2205	protein histidine kinase activity
HCN54_RS10460	COG4946	Tricorn protease homolog
HCN54_RS10460	COG0823	Involved in the tonB-independent uptake of proteins
HCN54_RS10460	COG1506	peptidase
HCN54_RS10470	COG4771	TonB-dependent receptor
HCN54_RS10535	COG3206	protein involved in exopolysaccharide biosynthesis
HCN54_RS10535	COG0489	protein tyrosine kinase activity
HCN54_RS10550	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HCN54_RS10565	COG0438	transferase activity, transferring glycosyl groups
HCN54_RS10620	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HCN54_RS10635	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HCN54_RS10645	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HCN54_RS10655	COG0778	Nitroreductase
HCN54_RS10665	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HCN54_RS10670	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HCN54_RS10670	COG0512	Glutamine amidotransferase of anthranilate synthase
HCN54_RS10675	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HCN54_RS10680	COG0134	indole-3-glycerol-phosphate synthase activity
HCN54_RS10685	COG0135	phosphoribosylanthranilate isomerase activity
HCN54_RS10690	COG0133	tryptophan synthase activity
HCN54_RS10700	COG0159	tryptophan synthase activity
HCN54_RS10705	COG0659	secondary active sulfate transmembrane transporter activity
HCN54_RS10730	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HCN54_RS10735	COG1181	Belongs to the D-alanine--D-alanine ligase family
HCN54_RS10745	COG0564	pseudouridine synthase activity
HCN54_RS10765	COG0653	protein targeting
HCN54_RS10780	COG0561	phosphatase activity
HCN54_RS10795	COG0326	Molecular chaperone. Has ATPase activity
HCN54_RS10800	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HCN54_RS10810	COG1335	isochorismatase
HCN54_RS10875	COG1482	cell wall glycoprotein biosynthetic process
HCN54_RS10885	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HCN54_RS10995	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HCN54_RS11000	COG0085	RNA polymerase activity
HCN54_RS11005	COG0222	ribosome binding
HCN54_RS11010	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HCN54_RS11015	COG0081	regulation of translation
HCN54_RS11020	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HCN54_RS11065	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HCN54_RS11070	COG4974	Belongs to the 'phage' integrase family
HCN54_RS11075	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HCN54_RS11080	COG1960	acyl-CoA dehydrogenase activity
HCN54_RS11090	COG1115	amino acid carrier protein
HCN54_RS11095	COG1115	amino acid carrier protein
HCN54_RS11100	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HCN54_RS11135	COG3876	Protein conserved in bacteria
HCN54_RS11195	COG0488	(ABC) transporter
HCN54_RS11210	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HCN54_RS11215	COG2814	Major facilitator Superfamily
HCN54_RS11235	COG1266	CAAX protease self-immunity
HCN54_RS11240	COG4948	Mandelate Racemase Muconate Lactonizing
HCN54_RS11245	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HCN54_RS11250	COG1575	Belongs to the MenA family. Type 1 subfamily
HCN54_RS11255	COG0366	Alpha amylase catalytic
HCN54_RS11260	COG2323	membrane
HCN54_RS11270	COG0667	Aldo Keto reductase
HCN54_RS11280	COG1028	Short-chain dehydrogenase reductase Sdr
HCN54_RS11305	COG0482	sulfurtransferase activity
HCN54_RS11310	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HCN54_RS11315	COG0706	membrane insertase activity
HCN54_RS11320	COG0504	CTP synthase activity
HCN54_RS11335	COG0534	Mate efflux family protein
HCN54_RS11355	COG2326	polyphosphate kinase activity
HCN54_RS11360	COG2204	response regulator
HCN54_RS11370	COG1196	nuclear chromosome segregation
HCN54_RS11370	COG3264	Mechanosensitive ion channel
HCN54_RS11380	COG4152	abc transporter atp-binding protein
HCN54_RS11385	COG0484	heat shock protein binding
HCN54_RS11390	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HCN54_RS11405	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HCN54_RS11410	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HCN54_RS11450	COG0438	transferase activity, transferring glycosyl groups
HCN54_RS11460	COG2827	Endonuclease containing a URI domain
HCN54_RS11470	COG2089	acid synthase
HCN54_RS11475	COG1083	cytidylyl-transferase
HCN54_RS11480	COG1442	glycosyl transferase family 8
HCN54_RS11480	COG1216	Glycosyl transferase, family 2
HCN54_RS11515	COG1215	transferase activity, transferring glycosyl groups
HCN54_RS11540	COG1216	Glycosyl transferase, family 2
HCN54_RS11565	COG0489	protein tyrosine kinase activity
HCN54_RS11565	COG3206	protein involved in exopolysaccharide biosynthesis
HCN54_RS11575	COG0514	ATP-dependent DNA helicase (RecQ)
HCN54_RS11585	COG0805	protein transport
HCN54_RS11595	COG1137	ATPase activity
HCN54_RS11600	COG1051	belongs to the nudix hydrolase family
HCN54_RS11605	COG1183	phosphatidylcholine synthase activity
HCN54_RS11625	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HCN54_RS11630	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HCN54_RS11640	COG3022	response to hydroperoxide
HCN54_RS11645	COG1136	(ABC) transporter
HCN54_RS11655	COG0488	(ABC) transporter
HCN54_RS11675	COG0477	Major facilitator Superfamily
HCN54_RS11675	COG2814	Major facilitator Superfamily
HCN54_RS11690	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HCN54_RS11695	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HCN54_RS11705	COG1663	tetraacyldisaccharide 4'-kinase activity
HCN54_RS11710	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HCN54_RS11720	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HCN54_RS11730	COG1902	pentaerythritol trinitrate reductase activity
HCN54_RS11745	COG0415	Belongs to the DNA photolyase family
HCN54_RS11750	COG3046	protein related to deoxyribodipyrimidine photolyase
HCN54_RS11765	COG0656	L-ascorbic acid biosynthetic process
HCN54_RS11785	COG2814	Major facilitator Superfamily
HCN54_RS11795	COG1741	Belongs to the pirin family
HCN54_RS11810	COG3844	kynureninase activity
HCN54_RS11815	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HCN54_RS11825	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HCN54_RS11855	COG3340	Belongs to the peptidase S51 family
HCN54_RS11885	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HCN54_RS11915	COG0564	pseudouridine synthase activity
HCN54_RS12040	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
HCN54_RS12070	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HCN54_RS12095	COG1051	belongs to the nudix hydrolase family
HCN54_RS12100	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HCN54_RS12115	COG0799	negative regulation of ribosome biogenesis
HCN54_RS12120	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HCN54_RS12130	COG4589	Belongs to the CDS family
HCN54_RS12135	COG0688	phosphatidylethanolamine metabolic process
HCN54_RS12145	COG0525	valine-tRNA ligase activity
HCN54_RS12160	COG0436	Aminotransferase
HCN54_RS12165	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HCN54_RS12170	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HCN54_RS12180	COG1216	Glycosyl transferase, family 2
HCN54_RS12195	COG1522	sequence-specific DNA binding
HCN54_RS12210	COG1703	isobutyryl-CoA mutase activity
HCN54_RS12210	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HCN54_RS12210	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HCN54_RS12215	COG0788	formyltetrahydrofolate deformylase activity
HCN54_RS12230	COG4771	TonB-dependent receptor
HCN54_RS12245	COG0284	orotidine-5'-phosphate decarboxylase activity
HCN54_RS12250	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HCN54_RS12265	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HCN54_RS12305	COG4206	TonB-dependent receptor
HCN54_RS12340	COG2003	Belongs to the UPF0758 family
HCN54_RS12350	COG0629	single-stranded DNA binding
HCN54_RS12355	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HCN54_RS12370	COG2205	protein histidine kinase activity
HCN54_RS12390	COG0561	phosphatase activity
HCN54_RS12395	COG1629	transport
HCN54_RS12410	COG3119	arylsulfatase activity
HCN54_RS12415	COG3119	arylsulfatase activity
HCN54_RS12420	COG0457	Tetratricopeptide repeat
HCN54_RS12435	COG2814	Major facilitator Superfamily
HCN54_RS12435	COG0477	Major facilitator Superfamily
HCN54_RS12455	COG0702	epimerase
HCN54_RS12460	COG4771	TonB-dependent receptor
HCN54_RS12485	COG4974	Belongs to the 'phage' integrase family
HCN54_RS12495	COG1610	YqeY-like protein
HCN54_RS12500	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HCN54_RS12515	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HCN54_RS12520	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HCN54_RS12525	COG0772	Belongs to the SEDS family
HCN54_RS12530	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HCN54_RS12535	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HCN54_RS12540	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HCN54_RS12545	COG0768	penicillin binding
HCN54_RS12555	COG0275	rRNA processing
HCN54_RS12560	COG2001	Belongs to the MraZ family
HCN54_RS12565	COG2267	carboxylic ester hydrolase activity
HCN54_RS12570	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HCN54_RS12590	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HCN54_RS12595	COG2197	response regulator
HCN54_RS12600	COG0358	DNA primase activity
HCN54_RS12625	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HCN54_RS12630	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HCN54_RS12660	COG1490	D-aminoacyl-tRNA deacylase activity
HCN54_RS12665	COG1162	GTPase activity
HCN54_RS12675	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HCN54_RS12680	COG0287	Prephenate dehydrogenase
HCN54_RS12685	COG0436	Aminotransferase
HCN54_RS12720	COG1028	Short-chain dehydrogenase reductase Sdr
HCN54_RS12725	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HCN54_RS12745	COG0848	biopolymer transport protein
HCN54_RS12750	COG0811	peptide transport
HCN54_RS12755	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HCN54_RS12765	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HCN54_RS12770	COG1960	acyl-CoA dehydrogenase activity
HCN54_RS12775	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HCN54_RS12780	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HCN54_RS12785	COG1085	galactose-1-phosphate uridylyltransferase
HCN54_RS12795	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HCN54_RS12800	COG0647	UMP catabolic process
HCN54_RS12805	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HCN54_RS12845	COG1629	transport
HCN54_RS12845	COG4206	TonB-dependent receptor
HCN54_RS12880	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HCN54_RS12920	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HCN54_RS12930	COG0544	peptidyl-prolyl cis-trans isomerase activity
HCN54_RS12935	COG1950	PFAM Membrane protein of
HCN54_RS12950	COG0596	Alpha beta hydrolase
HCN54_RS12955	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HCN54_RS12965	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HCN54_RS12975	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HCN54_RS12995	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HCN54_RS13015	COG0668	transmembrane transport
HCN54_RS13020	COG1214	PFAM Peptidase M22, glycoprotease
HCN54_RS13040	COG1136	(ABC) transporter
HCN54_RS13040	COG0577	efflux transmembrane transporter activity
HCN54_RS13045	COG1136	(ABC) transporter
HCN54_RS13045	COG0577	efflux transmembrane transporter activity
HCN54_RS13050	COG1136	(ABC) transporter
HCN54_RS13060	COG2322	membrane
HCN54_RS13065	COG1999	signal sequence binding
HCN54_RS13085	COG1845	cytochrome c oxidase, subunit III
HCN54_RS13090	COG0109	protoheme IX farnesyltransferase activity
HCN54_RS13120	COG0509	glycine decarboxylation via glycine cleavage system
HCN54_RS13130	COG0632	four-way junction helicase activity
HCN54_RS13145	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HCN54_RS13155	COG2255	four-way junction helicase activity
HCN54_RS13160	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HCN54_RS13165	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HCN54_RS13185	COG3743	rRNA binding
HCN54_RS13185	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HCN54_RS13190	COG0437	4 iron, 4 sulfur cluster binding
HCN54_RS13205	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HCN54_RS13210	COG0195	Participates in both transcription termination and antitermination
HCN54_RS13210	COG2251	uridine kinase activity
HCN54_RS13215	COG0779	Required for maturation of 30S ribosomal subunits
HCN54_RS13245	COG3118	belongs to the thioredoxin family
HCN54_RS13250	COG1408	metallophosphoesterase
HCN54_RS13255	COG1446	asparaginase
HCN54_RS13265	COG0084	hydrolase, TatD family'
HCN54_RS13275	COG0252	asparaginase activity
HCN54_RS13285	COG0811	peptide transport
HCN54_RS13295	COG0848	biopolymer transport protein
HCN54_RS13315	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HCN54_RS13325	COG4585	Histidine kinase
HCN54_RS13350	COG0017	Asparaginyl-tRNA synthetase
HCN54_RS13365	COG0233	cytoplasmic translational termination
HCN54_RS13370	COG0528	UMP kinase activity
HCN54_RS13375	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HCN54_RS13380	COG0052	Belongs to the universal ribosomal protein uS2 family
HCN54_RS13385	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HCN54_RS13390	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HCN54_RS13400	COG1629	transport
HCN54_RS13400	COG4206	TonB-dependent receptor
HCN54_RS13415	COG1629	transport
HCN54_RS13420	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HCN54_RS13420	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HCN54_RS13430	COG0508	dehydrogenase complex catalyzes the overall conversion of
HCN54_RS13455	COG1309	transcriptional regulator
HCN54_RS13475	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HCN54_RS13485	COG1629	transport
HCN54_RS13490	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HCN54_RS13495	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HCN54_RS13525	COG0753	catalase activity
HCN54_RS13560	COG0436	Aminotransferase
HCN54_RS13570	COG2095	MarC family integral membrane protein
HCN54_RS13585	COG0793	Belongs to the peptidase S41A family
HCN54_RS13590	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HCN54_RS13590	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HCN54_RS13635	COG4585	Histidine kinase
HCN54_RS13640	COG2197	response regulator
HCN54_RS13670	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HCN54_RS13685	COG2151	metal-sulfur cluster biosynthetic enzyme
HCN54_RS13695	COG2166	iron-sulfur cluster assembly
HCN54_RS13705	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HCN54_RS13710	COG0719	Fe-S assembly protein
HCN54_RS13715	COG0396	ATPase activity
HCN54_RS13720	COG0719	Fe-S assembly protein
HCN54_RS13730	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HCN54_RS13740	COG0596	Alpha beta hydrolase
HCN54_RS13745	COG1114	Component of the transport system for branched-chain amino acids
HCN54_RS13805	COG4191	Histidine kinase
HCN54_RS13840	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HCN54_RS13855	COG0366	Alpha amylase catalytic
HCN54_RS13870	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HCN54_RS13875	COG4206	TonB-dependent receptor
HCN54_RS13875	COG1629	transport
HCN54_RS13890	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HCN54_RS13895	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HCN54_RS13900	COG0193	aminoacyl-tRNA hydrolase activity
HCN54_RS13905	COG0196	riboflavin kinase activity
HCN54_RS13915	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HCN54_RS13930	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HCN54_RS13935	COG2239	Acts as a magnesium transporter
HCN54_RS13940	COG0824	Thioesterase
HCN54_RS13945	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HCN54_RS13970	COG0527	aspartate kinase activity
HCN54_RS13990	COG1793	dna ligase
HCN54_RS13995	COG1201	RNA secondary structure unwinding
HCN54_RS14000	COG2764	glyoxalase bleomycin resistance protein dioxygenase
HCN54_RS14015	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HCN54_RS14020	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HCN54_RS14025	COG0792	nuclease activity
HCN54_RS14030	COG1619	proteins homologs of microcin C7 resistance protein MccF
HCN54_RS14035	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HCN54_RS14035	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HCN54_RS14040	COG2827	Endonuclease containing a URI domain
HCN54_RS14055	COG0123	including yeast histone deacetylase and acetoin utilization protein
HCN54_RS14070	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HCN54_RS14075	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HCN54_RS14080	COG0629	single-stranded DNA binding
HCN54_RS14085	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HCN54_RS14085	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HCN54_RS14090	COG2318	DinB family
HCN54_RS14115	COG0527	aspartate kinase activity
HCN54_RS14125	COG3590	peptidase
HCN54_RS14155	COG1629	transport
HCN54_RS14185	COG1418	mRNA catabolic process
HCN54_RS14190	COG0204	Acyl-transferase
HCN54_RS14205	COG1476	TRANSCRIPTIONal
HCN54_RS14215	COG1929	Belongs to the glycerate kinase type-1 family
HCN54_RS14220	COG2610	gluconate transmembrane transporter activity
HCN54_RS14235	COG1999	signal sequence binding
HCN54_RS14275	COG1321	iron dependent repressor
HCN54_RS14275	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HCN54_RS14280	COG4771	TonB-dependent receptor
HCN54_RS14290	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
HCN54_RS14300	COG1028	Short-chain dehydrogenase reductase Sdr
HCN54_RS14345	COG1278	Cold shock
HCN54_RS14350	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HCN54_RS14370	COG0423	glycine-tRNA ligase activity
HCN54_RS14385	COG0708	Exodeoxyribonuclease III
HCN54_RS14390	COG1360	Flagellar Motor Protein
HCN54_RS14395	COG0667	Aldo Keto reductase
HCN54_RS14400	COG0545	Peptidyl-prolyl cis-trans isomerase
HCN54_RS14410	COG0545	Peptidyl-prolyl cis-trans isomerase
HCN54_RS14415	COG1960	acyl-CoA dehydrogenase activity
HCN54_RS14435	COG0798	PFAM Bile acid sodium symporter
HCN54_RS14440	COG0739	heme binding
HCN54_RS14455	COG1024	Enoyl-CoA hydratase
HCN54_RS14460	COG5000	phosphorelay sensor kinase activity
HCN54_RS14475	COG0534	Mate efflux family protein
HCN54_RS14480	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HCN54_RS14495	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HCN54_RS14500	COG0181	hydroxymethylbilane synthase activity
HCN54_RS14510	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HCN54_RS14520	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
HCN54_RS14530	COG0408	coproporphyrinogen oxidase activity
HCN54_RS14535	COG0113	porphobilinogen synthase activity
HCN54_RS14570	COG0450	alkyl hydroperoxide reductase
HCN54_RS14575	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HCN54_RS14590	COG1774	PSP1 C-terminal conserved region
HCN54_RS14600	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HCN54_RS14610	COG1595	DNA-templated transcription, initiation
HCN54_RS14630	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HCN54_RS14630	COG0758	DNA mediated transformation
HCN54_RS14640	COG1607	acyl-coa hydrolase
HCN54_RS14645	COG1473	amidohydrolase
HCN54_RS14665	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HCN54_RS14670	COG0756	dUTP diphosphatase activity
HCN54_RS14685	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HCN54_RS14695	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HCN54_RS14700	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HCN54_RS14705	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HCN54_RS14710	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HCN54_RS14715	COG0356	it plays a direct role in the translocation of protons across the membrane
HCN54_RS14740	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HCN54_RS14750	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HCN54_RS14800	COG0151	Belongs to the GarS family
HCN54_RS14810	COG1215	transferase activity, transferring glycosyl groups
HCN54_RS14820	COG0438	transferase activity, transferring glycosyl groups
HCN54_RS14860	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HCN54_RS14870	COG3942	CHAP domain
HCN54_RS14870	COG1388	LysM domain
HCN54_RS14875	COG0126	phosphoglycerate kinase activity
HCN54_RS14880	COG0470	DNA polymerase III
HCN54_RS14895	COG0445	tRNA wobble uridine modification
HCN54_RS14900	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HCN54_RS14910	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HCN54_RS14940	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HCN54_RS14965	COG0557	exoribonuclease II activity
HCN54_RS14970	COG2153	protein acetylation
HCN54_RS14980	COG0793	Belongs to the peptidase S41A family
HCN54_RS14985	COG0594	ribonuclease P activity
HCN54_RS15005	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HCN54_RS15025	COG0481	GTPase activity
HCN54_RS15045	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HCN54_RS15050	COG0346	lactoylglutathione lyase activity
HCN54_RS15070	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HCN54_RS15080	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HCN54_RS15085	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HCN54_RS15090	COG0511	ligase activity, forming carbon-carbon bonds
HCN54_RS15095	COG0439	Biotin carboxylase
HCN54_RS15105	COG3842	ATPase activity
HCN54_RS15110	COG1505	serine-type exopeptidase activity
HCN54_RS15115	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HCN54_RS15120	COG1970	mechanosensitive ion channel activity
HCN54_RS15125	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HCN54_RS15130	COG1435	thymidine kinase activity
HCN54_RS15140	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HCN54_RS15160	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HCN54_RS15160	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HCN54_RS15170	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HCN54_RS15175	COG0720	synthase
HCN54_RS15205	COG0038	chloride channel
HCN54_RS15230	COG2885	chlorophyll binding
HCN54_RS15230	COG3047	cAMP biosynthetic process
HCN54_RS15235	COG1074	ATP-dependent DNA helicase activity
HCN54_RS15255	COG3341	Caulimovirus viroplasmin
HCN54_RS15255	COG0328	RNA-DNA hybrid ribonuclease activity
HCN54_RS15260	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HCN54_RS15265	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HCN54_RS15270	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HCN54_RS15275	COG0571	ribonuclease III activity
HCN54_RS15290	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HCN54_RS15300	COG2954	triphosphatase activity
HCN54_RS15320	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HCN54_RS15330	COG4953	penicillin-binding protein 1C
HCN54_RS15335	COG2373	Large extracellular alpha-helical protein
HCN54_RS15350	COG1446	asparaginase
HCN54_RS15355	COG0662	Cupin 2, conserved barrel domain protein
HCN54_RS15360	COG1012	belongs to the aldehyde dehydrogenase family
HCN54_RS15370	COG4260	virion core protein, lumpy skin disease virus
HCN54_RS15385	COG4221	oxidoreductase activity
HCN54_RS15390	COG0714	Associated with various cellular activities
HCN54_RS15410	COG2304	oxidoreductase activity
HCN54_RS15430	COG0288	reversible hydration of carbon dioxide
HCN54_RS15435	COG1286	toxin biosynthetic process
HCN54_RS15450	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HCN54_RS15465	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HCN54_RS15475	COG1652	LysM domain
HCN54_RS15480	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HCN54_RS15485	COG0194	GDP metabolic process
HCN54_RS15490	COG1561	YicC-like family, N-terminal region
HCN54_RS15510	COG0673	inositol 2-dehydrogenase activity
HCN54_RS15515	COG2211	Major facilitator Superfamily
HCN54_RS15545	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
HCN54_RS15560	COG3781	membrane
HCN54_RS15590	COG0626	cystathionine gamma-synthase activity
HCN54_RS15600	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HCN54_RS15610	COG1381	Involved in DNA repair and RecF pathway recombination
HCN54_RS15615	COG4771	TonB-dependent receptor
HCN54_RS15635	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HCN54_RS15650	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HCN54_RS15655	COG5002	protein histidine kinase activity
HCN54_RS15660	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HCN54_RS15675	COG4067	protein conserved in archaea
HCN54_RS15675	COG0189	ligase activity
HCN54_RS15680	COG0322	excinuclease ABC activity
HCN54_RS15685	COG1752	Esterase of the alpha-beta hydrolase superfamily
HCN54_RS15690	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
HCN54_RS15695	COG3185	4-Hydroxyphenylpyruvate dioxygenase
HCN54_RS15705	COG3483	tryptophan 2,3-dioxygenase activity
HCN54_RS15715	COG0166	Belongs to the GPI family
HCN54_RS15720	COG4771	TonB-dependent receptor
HCN54_RS15730	COG2356	endonuclease I
HCN54_RS15740	COG0006	proline dipeptidase activity
HCN54_RS15765	COG1053	succinate dehydrogenase
HCN54_RS15770	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HCN54_RS15775	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HCN54_RS15790	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HCN54_RS15795	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HCN54_RS15800	COG0297	glycogen (starch) synthase activity
HCN54_RS15810	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HCN54_RS15820	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HCN54_RS15830	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
HCN54_RS15840	COG3655	Transcriptional regulator
HCN54_RS15850	COG0156	8-amino-7-oxononanoate synthase activity
HCN54_RS15855	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HCN54_RS15875	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HCN54_RS15880	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HCN54_RS15895	COG1530	ribonuclease E activity
HCN54_RS15900	COG0776	regulation of translation
HCN54_RS15905	COG1194	a g-specific adenine glycosylase
HCN54_RS15910	COG0629	single-stranded DNA binding
HCN54_RS15930	COG0612	Peptidase, M16
HCN54_RS15935	COG0612	Peptidase, M16
HCN54_RS15945	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HCN54_RS15950	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HCN54_RS15980	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HCN54_RS15990	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
HCN54_RS16025	COG2204	response regulator
HCN54_RS16030	COG5002	protein histidine kinase activity
HCN54_RS16030	COG0784	Response regulator, receiver
HCN54_RS16045	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HCN54_RS16060	COG0494	nUDIX hydrolase
HCN54_RS16065	COG3852	Histidine kinase
HCN54_RS16070	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HCN54_RS16080	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HCN54_RS16085	COG0519	Catalyzes the synthesis of GMP from XMP
HCN54_RS16100	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HCN54_RS16105	COG1968	undecaprenyl-diphosphatase activity
HCN54_RS16115	COG2177	Part of the ABC transporter FtsEX involved in
HCN54_RS16125	COG0495	leucyl-tRNA aminoacylation
HCN54_RS16135	COG2738	Putative neutral zinc metallopeptidase
HCN54_RS16150	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HCN54_RS16165	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HCN54_RS16170	COG0463	Glycosyl transferase, family 2
HCN54_RS16185	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HCN54_RS16190	COG2363	Small membrane protein
HCN54_RS16200	COG1522	sequence-specific DNA binding
HCN54_RS16215	COG0745	RESPONSE REGULATOR receiver
HCN54_RS16220	COG5002	protein histidine kinase activity
HCN54_RS16230	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HCN54_RS16245	COG0489	protein tyrosine kinase activity
HCN54_RS16285	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HCN54_RS16290	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HCN54_RS16295	COG0228	four-way junction DNA binding
HCN54_RS16320	COG4206	TonB-dependent receptor
HCN54_RS16320	COG1629	transport
HCN54_RS16340	COG0513	Belongs to the DEAD box helicase family
HCN54_RS16350	COG3119	arylsulfatase activity
HCN54_RS16360	COG1472	Belongs to the glycosyl hydrolase 3 family
HCN54_RS16380	COG0702	epimerase
HCN54_RS16385	COG4771	TonB-dependent receptor
HCN54_RS16435	COG3279	Response regulator of the LytR AlgR family
HCN54_RS16450	COG3279	Response regulator of the LytR AlgR family
HCN54_RS16455	COG3275	phosphorelay sensor kinase activity
HCN54_RS16470	COG4771	TonB-dependent receptor
HCN54_RS16485	COG0584	glycerophosphoryl diester phosphodiesterase
HCN54_RS16500	COG4206	TonB-dependent receptor
HCN54_RS16510	COG3384	dioxygenase
HCN54_RS16515	COG2382	esterase
HCN54_RS16575	COG2814	Major facilitator Superfamily
HCN54_RS16585	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HCN54_RS16600	COG3940	Belongs to the glycosyl hydrolase 43 family
HCN54_RS16610	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HCN54_RS16635	COG0348	domain, Protein
HCN54_RS16650	COG3278	Belongs to the heme-copper respiratory oxidase family
HCN54_RS16670	COG4206	TonB-dependent receptor
HCN54_RS16670	COG1629	transport
HCN54_RS16680	COG1785	Belongs to the alkaline phosphatase family
HCN54_RS16685	COG1785	Belongs to the alkaline phosphatase family
HCN54_RS16700	COG3852	Histidine kinase
HCN54_RS16715	COG1136	(ABC) transporter
HCN54_RS16720	COG1136	(ABC) transporter
HCN54_RS16720	COG0577	efflux transmembrane transporter activity
HCN54_RS16730	COG0577	efflux transmembrane transporter activity
HCN54_RS16730	COG1136	(ABC) transporter
HCN54_RS16735	COG0577	efflux transmembrane transporter activity
HCN54_RS16740	COG0577	efflux transmembrane transporter activity
HCN54_RS16740	COG1136	(ABC) transporter
HCN54_RS16745	COG1538	Outer membrane efflux protein
HCN54_RS16760	COG1741	Belongs to the pirin family
HCN54_RS16770	COG1002	Type II restriction enzyme, methylase subunits
HCN54_RS16780	COG1061	Type III restriction enzyme res subunit
HCN54_RS16785	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HCN54_RS16820	COG1629	transport
HCN54_RS16825	COG0702	epimerase
HCN54_RS16845	COG5520	Belongs to the glycosyl hydrolase 30 family
HCN54_RS16855	COG4974	Belongs to the 'phage' integrase family
HCN54_RS16870	COG0740	serine-type endopeptidase activity
HCN54_RS16880	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HCN54_RS16930	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HCN54_RS16940	COG1428	Deoxynucleoside kinase
HCN54_RS16975	COG1519	Transferase
HCN54_RS17020	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HCN54_RS17050	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
HCN54_RS17055	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HCN54_RS17065	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HCN54_RS17075	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HCN54_RS17085	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HCN54_RS17090	COG2086	electron transfer activity
HCN54_RS17095	COG0022	dehydrogenase e1 component
HCN54_RS17095	COG0508	dehydrogenase complex catalyzes the overall conversion of
HCN54_RS17105	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HCN54_RS17120	COG2988	succinylglutamate desuccinylase activity
HCN54_RS17125	COG0189	ligase activity
HCN54_RS17135	COG1428	Deoxynucleoside kinase
HCN54_RS17175	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HCN54_RS17180	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HCN54_RS17185	COG0460	homoserine dehydrogenase
HCN54_RS17185	COG0527	aspartate kinase activity
HCN54_RS17190	COG1765	OsmC-like protein
HCN54_RS17200	COG1959	2 iron, 2 sulfur cluster binding
HCN54_RS17215	COG0175	sulfate reduction
HCN54_RS17225	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HCN54_RS17240	COG0492	ferredoxin-NADP+ reductase activity
HCN54_RS17260	COG1410	methionine synthase
HCN54_RS17260	COG0646	methionine synthase
HCN54_RS17270	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HCN54_RS17280	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HCN54_RS17305	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HCN54_RS17310	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HCN54_RS17335	COG2315	Protein conserved in bacteria
HCN54_RS17340	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HCN54_RS17370	COG2207	Transcriptional regulator
HCN54_RS17375	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HCN54_RS17390	COG3938	Belongs to the proline racemase family
HCN54_RS17400	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HCN54_RS17425	COG2824	Alkylphosphonate utilization operon protein PhnA