locus-tag	class	description
A9E78_RS00010	COG0592	DNA-directed DNA polymerase activity
A9E78_RS00020	COG0187	DNA topoisomerase II activity
A9E78_RS00025	COG2957	Belongs to the agmatine deiminase family
A9E78_RS00030	COG1166	arginine decarboxylase activity
A9E78_RS00050	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A9E78_RS00055	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A9E78_RS00065	COG1741	Belongs to the pirin family
A9E78_RS00075	COG1566	PFAM secretion protein HlyD family protein
A9E78_RS00095	COG3227	Zinc metalloprotease (Elastase)
A9E78_RS00105	COG3028	Belongs to the UPF0307 family
A9E78_RS00110	COG0116	Belongs to the methyltransferase superfamily
A9E78_RS00110	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A9E78_RS00130	COG0531	amino acid
A9E78_RS00135	COG0306	phosphate transporter
A9E78_RS00155	COG2234	aminopeptidase activity
A9E78_RS00215	COG3781	membrane
A9E78_RS00265	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
A9E78_RS00280	COG0583	DNA-binding transcription factor activity
A9E78_RS00295	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
A9E78_RS00365	COG0436	Aminotransferase
A9E78_RS00370	COG0556	nucleotide-excision repair
A9E78_RS00380	COG4251	negative regulation of phosphorylation
A9E78_RS00380	COG3706	GGDEF domain
A9E78_RS00380	COG2203	Gaf domain
A9E78_RS00380	COG5001	Diguanylate cyclase
A9E78_RS00385	COG0069	glutamate synthase activity
A9E78_RS00390	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
A9E78_RS00395	COG3079	Belongs to the UPF0149 family
A9E78_RS00400	COG0006	proline dipeptidase activity
A9E78_RS00405	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A9E78_RS00410	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A9E78_RS00440	COG0189	ligase activity
A9E78_RS00440	COG4067	protein conserved in archaea
A9E78_RS00460	COG1671	Belongs to the UPF0178 family
A9E78_RS00475	COG0557	exoribonuclease II activity
A9E78_RS00480	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A9E78_RS00485	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
A9E78_RS00500	COG2824	Alkylphosphonate utilization operon protein PhnA
A9E78_RS00525	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A9E78_RS00535	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A9E78_RS00545	COG2252	PERMEase
A9E78_RS00575	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
A9E78_RS00580	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A9E78_RS00590	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A9E78_RS00600	COG0404	The glycine cleavage system catalyzes the degradation of glycine
A9E78_RS00620	COG1116	anion transmembrane transporter activity
A9E78_RS00625	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A9E78_RS00645	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A9E78_RS00665	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
A9E78_RS00690	COG0469	pyruvate kinase activity
A9E78_RS00695	COG0126	phosphoglycerate kinase activity
A9E78_RS00700	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A9E78_RS00705	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
A9E78_RS00715	COG0339	signal peptide processing
A9E78_RS00740	COG2801	Transposase and inactivated derivatives
A9E78_RS00745	COG2963	transposase activity
A9E78_RS00800	COG5001	Diguanylate cyclase
A9E78_RS00805	COG2200	EAL domain
A9E78_RS00810	COG0024	Methionine aminopeptidase
A9E78_RS00850	COG2354	Protein conserved in bacteria
A9E78_RS00855	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
A9E78_RS00885	COG0583	DNA-binding transcription factor activity
A9E78_RS00900	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A9E78_RS00905	COG2814	Major facilitator Superfamily
A9E78_RS00915	COG2226	methyltransferase
A9E78_RS00920	COG0501	Belongs to the peptidase M48B family
A9E78_RS00950	COG1172	Belongs to the binding-protein-dependent transport system permease family
A9E78_RS00960	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A9E78_RS00980	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
A9E78_RS00995	COG0393	Putative heavy-metal-binding
A9E78_RS01005	COG1271	oxidase subunit
A9E78_RS01010	COG1294	oxidase, subunit
A9E78_RS01025	COG1307	EDD domain protein, DegV family
A9E78_RS01030	COG1028	Short-chain dehydrogenase reductase Sdr
A9E78_RS01035	COG3046	protein related to deoxyribodipyrimidine photolyase
A9E78_RS01065	COG0415	Belongs to the DNA photolyase family
A9E78_RS01070	COG1346	cytolysis
A9E78_RS01075	COG1380	Effector of murein hydrolase LrgA
A9E78_RS01080	COG0583	DNA-binding transcription factor activity
A9E78_RS01085	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
A9E78_RS01110	COG3002	Belongs to the UPF0753 family
A9E78_RS01115	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A9E78_RS01120	COG0583	DNA-binding transcription factor activity
A9E78_RS01125	COG2274	protein secretion by the type I secretion system
A9E78_RS01145	COG0531	amino acid
A9E78_RS01155	COG3706	GGDEF domain
A9E78_RS01160	COG2217	Heavy metal translocating P-type atpase
A9E78_RS01165	COG0735	belongs to the Fur family
A9E78_RS01175	COG1196	nuclear chromosome segregation
A9E78_RS01195	COG1012	belongs to the aldehyde dehydrogenase family
A9E78_RS01210	COG2066	Belongs to the glutaminase family
A9E78_RS01215	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A9E78_RS01245	COG1393	Belongs to the ArsC family
A9E78_RS01255	COG0513	Belongs to the DEAD box helicase family
A9E78_RS01265	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
A9E78_RS01290	COG1566	PFAM secretion protein HlyD family protein
A9E78_RS01320	COG1573	uracil-dna glycosylase
A9E78_RS01345	COG0598	Magnesium transport protein CorA
A9E78_RS01355	COG0433	COG0433 Predicted ATPase
A9E78_RS01360	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
A9E78_RS01365	COG1335	isochorismatase
A9E78_RS01375	COG2814	Major facilitator Superfamily
A9E78_RS01380	COG0583	DNA-binding transcription factor activity
A9E78_RS01400	COG5002	protein histidine kinase activity
A9E78_RS01400	COG2198	Histidine kinase
A9E78_RS01400	COG0784	Response regulator, receiver
A9E78_RS01410	COG0583	DNA-binding transcription factor activity
A9E78_RS01420	COG2226	methyltransferase
A9E78_RS01440	COG4221	oxidoreductase activity
A9E78_RS01450	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
A9E78_RS01455	COG1509	lysine 2,3-aminomutase activity
A9E78_RS01490	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
A9E78_RS01500	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
A9E78_RS01505	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A9E78_RS01575	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A9E78_RS01605	COG0085	RNA polymerase activity
A9E78_RS01610	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
A9E78_RS01625	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A9E78_RS01770	COG0629	single-stranded DNA binding
A9E78_RS01775	COG2814	Major facilitator Superfamily
A9E78_RS01780	COG1028	Short-chain dehydrogenase reductase Sdr
A9E78_RS01795	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A9E78_RS01805	COG1560	Kdo2-lipid A biosynthetic process
A9E78_RS01820	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
A9E78_RS01835	COG2867	negative regulation of translational initiation
A9E78_RS01840	COG2914	Belongs to the UPF0125 (RnfH) family
A9E78_RS01845	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A9E78_RS01850	COG0735	belongs to the Fur family
A9E78_RS01855	COG3706	GGDEF domain
A9E78_RS01880	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
A9E78_RS01915	COG1704	LemA family
A9E78_RS01925	COG0842	Transport permease protein
A9E78_RS01930	COG1131	(ABC) transporter
A9E78_RS01960	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A9E78_RS01970	COG0336	Belongs to the RNA methyltransferase TrmD family
A9E78_RS01975	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
A9E78_RS01985	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A9E78_RS02005	COG0531	amino acid
A9E78_RS02045	COG1612	heme a metabolic process
A9E78_RS02055	COG1999	signal sequence binding
A9E78_RS02070	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
A9E78_RS02075	COG0363	glucosamine-6-phosphate deaminase activity
A9E78_RS02080	COG0129	dihydroxy-acid dehydratase activity
A9E78_RS02085	COG0837	glucose binding
A9E78_RS02090	COG0800	Aldolase
A9E78_RS02095	COG2814	Major facilitator Superfamily
A9E78_RS02105	COG3655	Transcriptional regulator
A9E78_RS02115	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
A9E78_RS02120	COG1278	Cold shock
A9E78_RS02140	COG1566	PFAM secretion protein HlyD family protein
A9E78_RS02155	COG1733	regulation of RNA biosynthetic process
A9E78_RS02270	COG0477	Major facilitator Superfamily
A9E78_RS02285	COG0138	bifunctional purine biosynthesis protein purh
A9E78_RS02290	COG2264	protein methyltransferase activity
A9E78_RS02295	COG0439	Biotin carboxylase
A9E78_RS02300	COG0511	ligase activity, forming carbon-carbon bonds
A9E78_RS02310	COG5016	pyruvate
A9E78_RS02310	COG0511	ligase activity, forming carbon-carbon bonds
A9E78_RS02315	COG3227	Zinc metalloprotease (Elastase)
A9E78_RS02325	COG3568	Endonuclease Exonuclease Phosphatase
A9E78_RS02330	COG3588	fructose-bisphosphate aldolase
A9E78_RS02350	COG1183	phosphatidylcholine synthase activity
A9E78_RS02360	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
A9E78_RS02365	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
A9E78_RS02380	COG0220	tRNA (guanine-N7-)-methyltransferase activity
A9E78_RS02385	COG1363	Peptidase, m42
A9E78_RS02395	COG0330	HflC and HflK could
A9E78_RS02400	COG0330	HflC and HflK could
A9E78_RS02405	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
A9E78_RS02425	COG1438	arginine binding
A9E78_RS02430	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A9E78_RS02435	COG0765	amino acid transport
A9E78_RS02440	COG1126	abc transporter atp-binding protein
A9E78_RS02445	COG0137	argininosuccinate synthase activity
A9E78_RS02450	COG0165	Argininosuccinate lyase
A9E78_RS02455	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A9E78_RS02470	COG0793	Belongs to the peptidase S41A family
A9E78_RS02475	COG4942	peptidase
A9E78_RS02480	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
A9E78_RS02495	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
A9E78_RS02500	COG0575	Belongs to the CDS family
A9E78_RS02520	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A9E78_RS02525	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A9E78_RS02530	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A9E78_RS02535	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
A9E78_RS02540	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
A9E78_RS02570	COG0656	L-ascorbic acid biosynthetic process
A9E78_RS02590	COG0572	uridine kinase
A9E78_RS02625	COG2009	succinate dehydrogenase
A9E78_RS02630	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
A9E78_RS02635	COG1053	succinate dehydrogenase
A9E78_RS02640	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
A9E78_RS02650	COG0508	dehydrogenase complex catalyzes the overall conversion of
A9E78_RS02660	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
A9E78_RS02680	COG2814	Major facilitator Superfamily
A9E78_RS02690	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
A9E78_RS02695	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
A9E78_RS02705	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
A9E78_RS02740	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A9E78_RS02755	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
A9E78_RS02775	COG1028	Short-chain dehydrogenase reductase Sdr
A9E78_RS02780	COG1028	Short-chain dehydrogenase reductase Sdr
A9E78_RS02800	COG2715	membrane protein required for spore maturation
A9E78_RS02805	COG0700	Nucleoside recognition
A9E78_RS02810	COG0739	heme binding
A9E78_RS02815	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
A9E78_RS02840	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
A9E78_RS02845	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A9E78_RS02850	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
A9E78_RS02865	COG0306	phosphate transporter
A9E78_RS02870	COG1392	Phosphate transport regulator
A9E78_RS02885	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
A9E78_RS02890	COG0540	Belongs to the ATCase OTCase family
A9E78_RS02900	COG0606	chelatase, subunit chli
A9E78_RS02910	COG0347	Belongs to the P(II) protein family
A9E78_RS02915	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
A9E78_RS02950	COG3243	poly(R)-hydroxyalkanoic acid synthase
A9E78_RS02955	COG1959	2 iron, 2 sulfur cluster binding
A9E78_RS02960	COG0719	Fe-S assembly protein
A9E78_RS02965	COG0396	ATPase activity
A9E78_RS02970	COG0719	Fe-S assembly protein
A9E78_RS02975	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A9E78_RS02980	COG0822	iron-sulfur transferase activity
A9E78_RS02985	COG2151	metal-sulfur cluster biosynthetic enzyme
A9E78_RS02990	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
A9E78_RS02995	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
A9E78_RS03000	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A9E78_RS03010	COG1253	flavin adenine dinucleotide binding
A9E78_RS03015	COG1064	alcohol dehydrogenase
A9E78_RS03045	COG0519	Catalyzes the synthesis of GMP from XMP
A9E78_RS03135	COG1435	thymidine kinase activity
A9E78_RS03150	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
A9E78_RS03170	COG1295	ribonuclease BN
A9E78_RS03190	COG2852	Protein conserved in bacteria
A9E78_RS03195	COG0708	Exodeoxyribonuclease III
A9E78_RS03200	COG0708	Exodeoxyribonuclease III
A9E78_RS03210	COG0281	malic enzyme
A9E78_RS03225	COG0338	D12 class N6 adenine-specific DNA methyltransferase
A9E78_RS03230	COG0814	amino acid
A9E78_RS03235	COG0814	amino acid
A9E78_RS03245	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A9E78_RS03250	COG1131	(ABC) transporter
A9E78_RS03255	COG0842	Transport permease protein
A9E78_RS03260	COG0842	Transport permease protein
A9E78_RS03270	COG0741	lytic transglycosylase activity
A9E78_RS03275	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
A9E78_RS03290	COG3220	belongs to the UPF0276 family
A9E78_RS03310	COG4689	acetoacetate decarboxylase
A9E78_RS03330	COG3220	belongs to the UPF0276 family
A9E78_RS03360	COG1131	(ABC) transporter
A9E78_RS03375	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A9E78_RS03380	COG4232	protein-disulfide reductase activity
A9E78_RS03395	COG0783	Belongs to the Dps family
A9E78_RS03400	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
A9E78_RS03405	COG0187	DNA topoisomerase II activity
A9E78_RS03420	COG0442	prolyl-tRNA aminoacylation
A9E78_RS03425	COG3177	Filamentation induced by cAMP protein fic
A9E78_RS03425	COG0666	response to abiotic stimulus
A9E78_RS03430	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
A9E78_RS03435	COG0659	secondary active sulfate transmembrane transporter activity
A9E78_RS03440	COG0037	tRNA processing
A9E78_RS03445	COG1538	Outer membrane efflux protein
A9E78_RS03450	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
A9E78_RS03455	COG0156	8-amino-7-oxononanoate synthase activity
A9E78_RS03460	COG1063	alcohol dehydrogenase
A9E78_RS03465	COG0488	(ABC) transporter
A9E78_RS03495	COG0010	Belongs to the arginase family
A9E78_RS03505	COG1228	amidohydrolase
A9E78_RS03515	COG1297	OPT oligopeptide transporter protein
A9E78_RS03520	COG0642	Histidine kinase
A9E78_RS03540	COG1823	symporter activity
A9E78_RS03550	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A9E78_RS03555	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A9E78_RS03590	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
A9E78_RS03595	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
A9E78_RS03600	COG0628	permease
A9E78_RS03620	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
A9E78_RS03620	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A9E78_RS03625	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A9E78_RS03635	COG0305	Participates in initiation and elongation during chromosome replication
A9E78_RS03675	COG2827	Endonuclease containing a URI domain
A9E78_RS03680	COG3104	oligopeptide transport
A9E78_RS03695	COG0107	imidazoleglycerol-phosphate synthase activity
A9E78_RS03705	COG1083	cytidylyl-transferase
A9E78_RS03710	COG2089	acid synthase
A9E78_RS03715	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
A9E78_RS03725	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A9E78_RS03740	COG1088	dTDP-glucose 4,6-dehydratase activity
A9E78_RS03760	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A9E78_RS03850	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
A9E78_RS03850	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
A9E78_RS03855	COG2091	lysine biosynthetic process via aminoadipic acid
A9E78_RS03865	COG0037	tRNA processing
A9E78_RS03880	COG1696	Membrane protein involved in D-alanine export
A9E78_RS03885	COG1760	l-serine dehydratase
A9E78_RS03890	COG0545	Peptidyl-prolyl cis-trans isomerase
A9E78_RS03895	COG2223	nitrite transmembrane transporter activity
A9E78_RS03900	COG2963	transposase activity
A9E78_RS03910	COG2801	Transposase and inactivated derivatives
A9E78_RS03930	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
A9E78_RS03935	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
A9E78_RS03940	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A9E78_RS03945	COG0659	secondary active sulfate transmembrane transporter activity
A9E78_RS03950	COG1960	acyl-CoA dehydrogenase activity
A9E78_RS03960	COG0574	Belongs to the PEP-utilizing enzyme family
A9E78_RS03960	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A9E78_RS03965	COG0475	glutathione-regulated potassium exporter activity
A9E78_RS03980	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A9E78_RS03985	COG1555	photosystem II stabilization
A9E78_RS03990	COG1077	Cell shape determining protein MreB Mrl
A9E78_RS03995	COG1792	Involved in formation and maintenance of cell shape
A9E78_RS04000	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
A9E78_RS04005	COG1187	pseudouridine synthase activity
A9E78_RS04025	COG0542	response to heat
A9E78_RS04055	COG0705	Rhomboid family
A9E78_RS04060	COG0739	heme binding
A9E78_RS04110	COG0512	Glutamine amidotransferase of anthranilate synthase
A9E78_RS04115	COG1137	ATPase activity
A9E78_RS04130	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
A9E78_RS04140	COG1127	ABC transporter
A9E78_RS04145	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A9E78_RS04150	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
A9E78_RS04165	COG5007	Belongs to the BolA IbaG family
A9E78_RS04180	COG1136	(ABC) transporter
A9E78_RS04185	COG0577	efflux transmembrane transporter activity
A9E78_RS04190	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A9E78_RS04210	COG0616	signal peptide processing
A9E78_RS04240	COG1138	Cytochrome C-type biogenesis protein
A9E78_RS04260	COG3360	Dodecin
A9E78_RS04275	COG0514	ATP-dependent DNA helicase (RecQ)
A9E78_RS04280	COG1960	acyl-CoA dehydrogenase activity
A9E78_RS04285	COG1024	Enoyl-CoA hydratase
A9E78_RS04290	COG1024	Enoyl-CoA hydratase
A9E78_RS04325	COG2340	Cysteine-rich secretory protein family
A9E78_RS04335	COG3706	GGDEF domain
A9E78_RS04360	COG1472	Belongs to the glycosyl hydrolase 3 family
A9E78_RS04380	COG0204	Acyl-transferase
A9E78_RS04385	COG0626	cystathionine gamma-synthase activity
A9E78_RS04430	COG1194	a g-specific adenine glycosylase
A9E78_RS04460	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A9E78_RS04485	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
A9E78_RS04535	COG1994	Peptidase M50
A9E78_RS04560	COG0686	Belongs to the AlaDH PNT family
A9E78_RS04615	COG0589	response to stress
A9E78_RS04620	COG0196	riboflavin kinase activity
A9E78_RS04635	COG0800	Aldolase
A9E78_RS04650	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
A9E78_RS04655	COG1381	Involved in DNA repair and RecF pathway recombination
A9E78_RS04675	COG0674	pyruvate-flavodoxin oxidoreductase activity
A9E78_RS04675	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
A9E78_RS04680	COG1013	pyruvate-flavodoxin oxidoreductase activity
A9E78_RS04685	COG0670	Belongs to the BI1 family
A9E78_RS04695	COG0312	modulator of DNA gyrase
A9E78_RS04700	COG1752	Esterase of the alpha-beta hydrolase superfamily
A9E78_RS04705	COG1022	Amp-dependent synthetase and ligase
A9E78_RS04710	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
A9E78_RS04730	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A9E78_RS04740	COG0601	transmembrane transport
A9E78_RS04745	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A9E78_RS04760	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
A9E78_RS04790	COG0833	amino acid
A9E78_RS04825	COG0629	single-stranded DNA binding
A9E78_RS04960	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
A9E78_RS04995	COG2217	Heavy metal translocating P-type atpase
A9E78_RS05045	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A9E78_RS05050	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A9E78_RS05055	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
A9E78_RS05060	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
A9E78_RS05065	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
A9E78_RS05070	COG2217	Heavy metal translocating P-type atpase
A9E78_RS05075	COG5002	protein histidine kinase activity
A9E78_RS05075	COG3447	MASE1 domain protein
A9E78_RS05075	COG5001	Diguanylate cyclase
A9E78_RS05120	COG2132	Multicopper oxidase
A9E78_RS05165	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A9E78_RS05185	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A9E78_RS05185	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
A9E78_RS05195	COG0356	it plays a direct role in the translocation of protons across the membrane
A9E78_RS05210	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
A9E78_RS05240	COG1028	Short-chain dehydrogenase reductase Sdr
A9E78_RS05245	COG1278	Cold shock
A9E78_RS05295	COG0582	viral genome integration into host DNA
A9E78_RS05335	COG0232	Belongs to the dGTPase family. Type 2 subfamily
A9E78_RS05355	COG4804	nuclease activity
A9E78_RS05360	COG0582	viral genome integration into host DNA
A9E78_RS05370	COG0728	peptidoglycan biosynthetic process
A9E78_RS05400	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A9E78_RS05405	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
A9E78_RS05420	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A9E78_RS05465	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A9E78_RS05465	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A9E78_RS05520	COG4251	negative regulation of phosphorylation
A9E78_RS05525	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
A9E78_RS05530	COG3469	chitinase activity
A9E78_RS05530	COG3325	Belongs to the glycosyl hydrolase 18 family
A9E78_RS05560	COG1388	LysM domain
A9E78_RS05560	COG0741	lytic transglycosylase activity
A9E78_RS05575	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A9E78_RS05590	COG0590	tRNA wobble adenosine to inosine editing
A9E78_RS05610	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A9E78_RS05620	COG2070	2-Nitropropane dioxygenase
A9E78_RS05650	COG1177	transmembrane transport
A9E78_RS05655	COG1176	ABC-type spermidine putrescine transport system, permease component I
A9E78_RS05660	COG3842	ATPase activity
A9E78_RS05685	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
A9E78_RS05720	COG1231	oxidoreductase activity
A9E78_RS05730	COG3961	Belongs to the TPP enzyme family
A9E78_RS05750	COG0697	spore germination
A9E78_RS05775	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A9E78_RS05795	COG1666	GTP binding
A9E78_RS05805	COG1355	regulation of microtubule-based process
A9E78_RS05845	COG4783	chaperone-mediated protein folding
A9E78_RS05850	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A9E78_RS05850	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A9E78_RS05855	COG0307	riboflavin synthase, alpha
A9E78_RS05860	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A9E78_RS05860	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A9E78_RS05885	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
A9E78_RS05900	COG2974	May be involved in recombination
A9E78_RS05915	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A9E78_RS05920	COG1472	Belongs to the glycosyl hydrolase 3 family
A9E78_RS05930	COG0140	phosphoribosyl-ATP diphosphatase activity
A9E78_RS05930	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
A9E78_RS05935	COG0107	imidazoleglycerol-phosphate synthase activity
A9E78_RS05940	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
A9E78_RS05945	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
A9E78_RS05950	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
A9E78_RS05950	COG0131	Imidazoleglycerol-phosphate dehydratase
A9E78_RS05955	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A9E78_RS05965	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
A9E78_RS05975	COG1271	oxidase subunit
A9E78_RS05980	COG1294	oxidase, subunit
A9E78_RS05995	COG1278	Cold shock
A9E78_RS06005	COG0442	prolyl-tRNA aminoacylation
A9E78_RS06010	COG1846	Transcriptional regulator
A9E78_RS06025	COG1280	lysine exporter protein (LysE YggA)
A9E78_RS06050	COG1815	bacterial-type flagellum-dependent cell motility
A9E78_RS06060	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
A9E78_RS06065	COG1749	Flagellar hook protein flgE
A9E78_RS06070	COG4787	bacterial-type flagellum-dependent cell motility
A9E78_RS06075	COG4786	Flagellar basal body rod
A9E78_RS06085	COG1706	bacterial-type flagellum-dependent cell motility
A9E78_RS06125	COG3273	potassium ion transport
A9E78_RS06125	COG0471	metal ion transport
A9E78_RS06140	COG1132	(ABC) transporter
A9E78_RS06155	COG0281	malic enzyme
A9E78_RS06165	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
A9E78_RS06180	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
A9E78_RS06185	COG0217	transcriptional regulatory protein
A9E78_RS06190	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
A9E78_RS06195	COG0632	four-way junction helicase activity
A9E78_RS06210	COG0642	Histidine kinase
A9E78_RS06220	COG2917	probably involved in intracellular septation
A9E78_RS06225	COG1388	LysM domain
A9E78_RS06225	COG0741	lytic transglycosylase activity
A9E78_RS06235	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A9E78_RS06240	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
A9E78_RS06250	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
A9E78_RS06270	COG1090	epimerase
A9E78_RS06280	COG0135	phosphoribosylanthranilate isomerase activity
A9E78_RS06285	COG0133	tryptophan synthase activity
A9E78_RS06290	COG0159	tryptophan synthase activity
A9E78_RS06295	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A9E78_RS06300	COG0215	cysteine-tRNA ligase activity
A9E78_RS06305	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
A9E78_RS06360	COG0673	inositol 2-dehydrogenase activity
A9E78_RS06365	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
A9E78_RS06370	COG2814	Major facilitator Superfamily
A9E78_RS06375	COG2814	Major facilitator Superfamily
A9E78_RS06380	COG4264	IucA IucC family
A9E78_RS06415	COG1496	oxidoreductase activity
A9E78_RS06465	COG0285	dihydrofolate synthase activity
A9E78_RS06475	COG1286	toxin biosynthetic process
A9E78_RS06480	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
A9E78_RS06495	COG0495	leucyl-tRNA aminoacylation
A9E78_RS06500	COG0815	Transfers the fatty acyl group on membrane lipoproteins
A9E78_RS06510	COG1012	belongs to the aldehyde dehydrogenase family
A9E78_RS06515	COG1250	3-hydroxyacyl-CoA dehydrogenase
A9E78_RS06515	COG1024	Enoyl-CoA hydratase
A9E78_RS06520	COG0183	Belongs to the thiolase family
A9E78_RS06545	COG3156	type II secretion system protein K
A9E78_RS06565	COG2165	general secretion pathway protein
A9E78_RS06575	COG0174	glutamine synthetase
A9E78_RS06585	COG3022	response to hydroperoxide
A9E78_RS06590	COG2515	1-aminocyclopropane-1-carboxylate deaminase
A9E78_RS06600	COG0326	Molecular chaperone. Has ATPase activity
A9E78_RS06605	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
A9E78_RS06610	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A9E78_RS06615	COG0673	inositol 2-dehydrogenase activity
A9E78_RS06620	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
A9E78_RS06625	COG0772	Belongs to the SEDS family
A9E78_RS06630	COG0768	penicillin binding
A9E78_RS06635	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
A9E78_RS06650	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
A9E78_RS06655	COG2986	histidine ammonia-lyase
A9E78_RS06665	COG0300	oxidoreductase activity
A9E78_RS06675	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A9E78_RS06695	COG0316	Belongs to the HesB IscA family
A9E78_RS06700	COG0482	sulfurtransferase activity
A9E78_RS06720	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A9E78_RS06725	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
A9E78_RS06735	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A9E78_RS06740	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A9E78_RS06745	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
A9E78_RS06750	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
A9E78_RS06755	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
A9E78_RS06765	COG0084	hydrolase, TatD family'
A9E78_RS06770	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
A9E78_RS06785	COG0463	Glycosyl transferase, family 2
A9E78_RS06815	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A9E78_RS06825	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
A9E78_RS06830	COG0372	Belongs to the citrate synthase family
A9E78_RS06845	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
A9E78_RS06850	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
A9E78_RS06855	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
A9E78_RS06870	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
A9E78_RS06880	COG0284	orotidine-5'-phosphate decarboxylase activity
A9E78_RS06890	COG4221	oxidoreductase activity
A9E78_RS06905	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
A9E78_RS06925	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
A9E78_RS06930	COG0295	cytidine deaminase activity
A9E78_RS06945	COG0745	RESPONSE REGULATOR receiver
A9E78_RS06950	COG4535	Mg2 and Co2 transporter CorC
A9E78_RS06960	COG1702	phosphate starvation-inducible protein PhoH
A9E78_RS06965	COG0613	PHP domain protein
A9E78_RS06970	COG0009	L-threonylcarbamoyladenylate synthase
A9E78_RS06975	COG0180	Tryptophanyl-tRNA synthetase
A9E78_RS06985	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
A9E78_RS06990	COG1187	pseudouridine synthase activity
A9E78_RS07010	COG1881	PFAM PEBP family protein
A9E78_RS07035	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A9E78_RS07040	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A9E78_RS07050	COG0436	Aminotransferase
A9E78_RS07060	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
A9E78_RS07065	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A9E78_RS07070	COG0653	protein targeting
A9E78_RS07075	COG0494	nUDIX hydrolase
A9E78_RS07090	COG0237	dephospho-CoA kinase activity
A9E78_RS07100	COG2200	EAL domain
A9E78_RS07110	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A9E78_RS07120	COG0156	8-amino-7-oxononanoate synthase activity
A9E78_RS07125	COG0596	Alpha beta hydrolase
A9E78_RS07130	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
A9E78_RS07145	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
A9E78_RS07150	COG3264	Mechanosensitive ion channel
A9E78_RS07150	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
A9E78_RS07185	COG1522	sequence-specific DNA binding
A9E78_RS07230	COG1196	nuclear chromosome segregation
A9E78_RS07235	COG0308	aminopeptidase N
A9E78_RS07255	COG0456	acetyltransferase
A9E78_RS07260	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A9E78_RS07265	COG0508	dehydrogenase complex catalyzes the overall conversion of
A9E78_RS07280	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
A9E78_RS07285	COG0475	glutathione-regulated potassium exporter activity
A9E78_RS07285	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A9E78_RS07290	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
A9E78_RS07295	COG1686	Belongs to the peptidase S11 family
A9E78_RS07305	COG2921	Belongs to the UPF0250 family
A9E78_RS07310	COG0321	lipoyl(octanoyl) transferase activity
A9E78_RS07315	COG0586	Pfam SNARE associated Golgi protein
A9E78_RS07325	COG3034	peptidoglycan biosynthetic process
A9E78_RS07330	COG2274	protein secretion by the type I secretion system
A9E78_RS07340	COG2203	Gaf domain
A9E78_RS07340	COG5001	Diguanylate cyclase
A9E78_RS07340	COG3706	GGDEF domain
A9E78_RS07340	COG4251	negative regulation of phosphorylation
A9E78_RS07345	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
A9E78_RS07370	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
A9E78_RS07400	COG0372	Belongs to the citrate synthase family
A9E78_RS07410	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
A9E78_RS07410	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A9E78_RS07420	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
A9E78_RS07430	COG1981	membrane
A9E78_RS07435	COG0861	Integral membrane protein TerC family
A9E78_RS07440	COG0617	tRNA 3'-terminal CCA addition
A9E78_RS07445	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
A9E78_RS07450	COG0589	response to stress
A9E78_RS07455	COG1160	GTP binding
A9E78_RS07470	COG0124	histidyl-tRNA synthetase
A9E78_RS07480	COG3063	Type IV pilus biogenesis stability protein PilW
A9E78_RS07485	COG0820	rRNA (adenine-C2-)-methyltransferase activity
A9E78_RS07490	COG0105	UTP biosynthetic process
A9E78_RS07510	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A9E78_RS07515	COG0850	regulation of cytokinetic process
A9E78_RS07520	COG0318	PFAM AMP-dependent synthetase and ligase
A9E78_RS07525	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A9E78_RS07535	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A9E78_RS07555	COG3264	Mechanosensitive ion channel
A9E78_RS07555	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
A9E78_RS07560	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A9E78_RS07575	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A9E78_RS07595	COG0352	thiamine-phosphate diphosphorylase activity
A9E78_RS07610	COG0823	Involved in the tonB-independent uptake of proteins
A9E78_RS07630	COG0824	Thioesterase
A9E78_RS07635	COG2255	four-way junction helicase activity
A9E78_RS07660	COG3038	cytochrome b561
A9E78_RS07665	COG2902	Dehydrogenase
A9E78_RS07670	COG1376	ErfK ybiS ycfS ynhG family protein
A9E78_RS07675	COG1012	belongs to the aldehyde dehydrogenase family
A9E78_RS07680	COG1183	phosphatidylcholine synthase activity
A9E78_RS07735	COG1376	ErfK ybiS ycfS ynhG family protein
A9E78_RS07735	COG1388	LysM domain
A9E78_RS07740	COG1024	Enoyl-CoA hydratase
A9E78_RS07740	COG1250	3-hydroxyacyl-CoA dehydrogenase
A9E78_RS07745	COG0183	Belongs to the thiolase family
A9E78_RS07775	COG5654	RES domain protein
A9E78_RS07785	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
A9E78_RS07790	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
A9E78_RS07795	COG0494	nUDIX hydrolase
A9E78_RS07800	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
A9E78_RS07805	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
A9E78_RS07810	COG0789	Transcriptional regulator
A9E78_RS07825	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
A9E78_RS07825	COG0456	acetyltransferase
A9E78_RS07830	COG1132	(ABC) transporter
A9E78_RS07835	COG0488	(ABC) transporter
A9E78_RS07850	COG0768	penicillin binding
A9E78_RS07870	COG0585	pseudouridine synthase activity
A9E78_RS07875	COG0429	hydrolase of the alpha beta-hydrolase fold
A9E78_RS07885	COG2217	Heavy metal translocating P-type atpase
A9E78_RS07910	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A9E78_RS07915	COG0438	transferase activity, transferring glycosyl groups
A9E78_RS07925	COG0277	FAD linked oxidase domain protein
A9E78_RS07925	COG0247	lactate metabolic process
A9E78_RS07945	COG0477	Major facilitator Superfamily
A9E78_RS07955	COG2119	membrane
A9E78_RS07960	COG0823	Involved in the tonB-independent uptake of proteins
A9E78_RS07970	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
A9E78_RS07985	COG3038	cytochrome b561
A9E78_RS07990	COG2353	YceI-like domain
A9E78_RS08010	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A9E78_RS08015	COG0673	inositol 2-dehydrogenase activity
A9E78_RS08020	COG2814	Major facilitator Superfamily
A9E78_RS08045	COG0531	amino acid
A9E78_RS08075	COG4953	penicillin-binding protein 1C
A9E78_RS08080	COG2373	Large extracellular alpha-helical protein
A9E78_RS08120	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
A9E78_RS08125	COG0151	Belongs to the GarS family
A9E78_RS08145	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
A9E78_RS08150	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A9E78_RS08165	COG4232	protein-disulfide reductase activity
A9E78_RS08170	COG0300	oxidoreductase activity
A9E78_RS08200	COG3144	bacterial-type flagellum assembly
A9E78_RS08210	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
A9E78_RS08215	COG0531	amino acid
A9E78_RS08225	COG3335	DDE superfamily endonuclease
A9E78_RS08265	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A9E78_RS08270	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
A9E78_RS08280	COG3138	arginine N-succinyltransferase
A9E78_RS08310	COG0528	UMP kinase activity
A9E78_RS08320	COG0052	Belongs to the universal ribosomal protein uS2 family
A9E78_RS08350	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
A9E78_RS08360	COG0519	Catalyzes the synthesis of GMP from XMP
A9E78_RS08360	COG0518	GMP synthase (glutamine-hydrolyzing) activity
A9E78_RS08370	COG2894	cell division
A9E78_RS08380	COG1960	acyl-CoA dehydrogenase activity
A9E78_RS08385	COG2267	carboxylic ester hydrolase activity
A9E78_RS08400	COG0395	ABC-type sugar transport system, permease component
A9E78_RS08405	COG1175	transmembrane transport
A9E78_RS08410	COG1063	alcohol dehydrogenase
A9E78_RS08415	COG0038	chloride channel
A9E78_RS08420	COG0512	Glutamine amidotransferase of anthranilate synthase
A9E78_RS08420	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A9E78_RS08425	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A9E78_RS08430	COG0154	amidase activity
A9E78_RS08435	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A9E78_RS08470	COG0316	Belongs to the HesB IscA family
A9E78_RS08480	COG1104	cysteine desulfurase activity
A9E78_RS08485	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
A9E78_RS08495	COG0616	signal peptide processing
A9E78_RS08500	COG0542	response to heat
A9E78_RS08515	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A9E78_RS08545	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
A9E78_RS08555	COG1677	Flagellar hook-basal body complex protein FliE
A9E78_RS08570	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A9E78_RS08580	COG1674	ftsk spoiiie
A9E78_RS08585	COG0492	ferredoxin-NADP+ reductase activity
A9E78_RS08595	COG0425	Belongs to the sulfur carrier protein TusA family
A9E78_RS08595	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A9E78_RS08605	COG0312	modulator of DNA gyrase
A9E78_RS08620	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
A9E78_RS08620	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A9E78_RS08655	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
A9E78_RS08730	COG0583	DNA-binding transcription factor activity
A9E78_RS08795	COG2911	Protein conserved in bacteria
A9E78_RS08800	COG0113	porphobilinogen synthase activity
A9E78_RS08815	COG0527	aspartate kinase activity
A9E78_RS08825	COG0489	protein tyrosine kinase activity
A9E78_RS08835	COG0583	DNA-binding transcription factor activity
A9E78_RS08840	COG2814	Major facilitator Superfamily
A9E78_RS08855	COG1132	(ABC) transporter
A9E78_RS08880	COG1960	acyl-CoA dehydrogenase activity
A9E78_RS08885	COG0183	Belongs to the thiolase family
A9E78_RS08895	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A9E78_RS08900	COG1024	Enoyl-CoA hydratase
A9E78_RS08915	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A9E78_RS08925	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A9E78_RS08930	COG2011	ABC-type metal ion transport system permease component
A9E78_RS08935	COG1464	Belongs to the NlpA lipoprotein family
A9E78_RS08945	COG0742	ribosomal rna small subunit methyltransferase
A9E78_RS08950	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
A9E78_RS08955	COG0751	glycine-tRNA ligase activity
A9E78_RS08970	COG0210	DNA helicase
A9E78_RS08990	COG0189	ligase activity
A9E78_RS09010	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A9E78_RS09020	COG1524	type I phosphodiesterase nucleotide pyrophosphatase
A9E78_RS09025	COG0572	uridine kinase
A9E78_RS09055	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
A9E78_RS09060	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
A9E78_RS09100	COG0488	(ABC) transporter
A9E78_RS09105	COG0571	ribonuclease III activity
A9E78_RS09125	COG2951	lytic endotransglycosylase activity
A9E78_RS09135	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
A9E78_RS09170	COG0346	lactoylglutathione lyase activity
A9E78_RS09190	COG1254	Belongs to the acylphosphatase family
A9E78_RS09205	COG0657	acetylesterase activity
A9E78_RS09225	COG2223	nitrite transmembrane transporter activity
A9E78_RS09230	COG0038	chloride channel
A9E78_RS09240	COG3012	SEC-C Motif Domain Protein
A9E78_RS09250	COG0714	Associated with various cellular activities
A9E78_RS09265	COG2850	peptidyl-arginine hydroxylation
A9E78_RS09290	COG3101	peptidyl-lysine hydroxylation
A9E78_RS09300	COG0625	glutathione transferase activity
A9E78_RS09315	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A9E78_RS09325	COG0205	6-phosphofructokinase activity
A9E78_RS09330	COG4969	Belongs to the N-Me-Phe pilin family
A9E78_RS09335	COG4969	Belongs to the N-Me-Phe pilin family
A9E78_RS09345	COG0531	amino acid
A9E78_RS09350	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
A9E78_RS09355	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
A9E78_RS09365	COG1214	PFAM Peptidase M22, glycoprotease
A9E78_RS09370	COG1199	ATP-dependent helicase activity
A9E78_RS09375	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
A9E78_RS09400	COG2313	pseudouridylate synthase activity
A9E78_RS09430	COG3550	peptidyl-serine autophosphorylation
A9E78_RS09470	COG1250	3-hydroxyacyl-CoA dehydrogenase
A9E78_RS09485	COG5212	phosphodiesterase
A9E78_RS09520	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
A9E78_RS09540	COG4948	Mandelate Racemase Muconate Lactonizing
A9E78_RS09620	COG0625	glutathione transferase activity
A9E78_RS09625	COG1764	response to oxidative stress
A9E78_RS09660	COG3774	pathogenesis
A9E78_RS09710	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
A9E78_RS09740	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
A9E78_RS09760	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A9E78_RS09770	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A9E78_RS09775	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A9E78_RS09780	COG1862	Preprotein translocase
A9E78_RS09785	COG0343	queuine tRNA-ribosyltransferase activity
A9E78_RS09790	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
A9E78_RS09800	COG0488	(ABC) transporter
A9E78_RS09805	COG3577	Aspartyl protease
A9E78_RS09815	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A9E78_RS09825	COG0194	GDP metabolic process
A9E78_RS09830	COG1561	YicC-like family, N-terminal region
A9E78_RS09880	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
A9E78_RS09885	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
A9E78_RS09890	COG0505	Belongs to the CarA family
A9E78_RS09900	COG0443	Heat shock 70 kDa protein
A9E78_RS09910	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
A9E78_RS09915	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
A9E78_RS09920	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
A9E78_RS09930	COG0018	arginyl-trna synthetase
A9E78_RS09935	COG0628	permease
A9E78_RS09960	COG0424	maF-like protein
A9E78_RS09965	COG0148	phosphopyruvate hydratase activity
A9E78_RS09970	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
A9E78_RS09990	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
A9E78_RS09995	COG2885	chlorophyll binding
A9E78_RS10000	COG3218	ABC-type transport auxiliary lipoprotein component
A9E78_RS10010	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A9E78_RS10015	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A9E78_RS10035	COG1304	FMN binding
A9E78_RS10065	COG0582	viral genome integration into host DNA
A9E78_RS10110	COG5265	(ABC) transporter
A9E78_RS10115	COG5265	(ABC) transporter
A9E78_RS10120	COG0656	L-ascorbic acid biosynthetic process
A9E78_RS10145	COG3344	reverse transcriptase
A9E78_RS10270	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
A9E78_RS10295	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A9E78_RS10295	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A9E78_RS10300	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A9E78_RS10300	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A9E78_RS10310	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A9E78_RS10330	COG3220	belongs to the UPF0276 family
A9E78_RS10355	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A9E78_RS10355	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A9E78_RS10400	COG1278	Cold shock
A9E78_RS10405	COG0513	Belongs to the DEAD box helicase family
A9E78_RS10425	COG3158	transport of potassium into the cell
A9E78_RS10460	COG0477	Major facilitator Superfamily
A9E78_RS10470	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A9E78_RS10490	COG0259	pyridoxamine-phosphate oxidase activity
A9E78_RS10495	COG1733	regulation of RNA biosynthetic process
A9E78_RS10500	COG1028	Short-chain dehydrogenase reductase Sdr
A9E78_RS10555	COG1132	(ABC) transporter
A9E78_RS10560	COG1196	nuclear chromosome segregation
A9E78_RS10565	COG1196	nuclear chromosome segregation
A9E78_RS10570	COG1413	lyase activity
A9E78_RS10575	COG1196	nuclear chromosome segregation
A9E78_RS10580	COG1196	nuclear chromosome segregation
A9E78_RS10610	COG4977	sequence-specific DNA binding
A9E78_RS10655	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
A9E78_RS10675	COG0076	glutamate decarboxylase activity
A9E78_RS10690	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A9E78_RS10695	COG0784	Response regulator, receiver
A9E78_RS10695	COG2205	protein histidine kinase activity
A9E78_RS10700	COG2198	Histidine kinase
A9E78_RS10700	COG0784	Response regulator, receiver
A9E78_RS10700	COG5002	protein histidine kinase activity
A9E78_RS10705	COG4106	trans-aconitate 2-methyltransferase activity
A9E78_RS10730	COG0861	Integral membrane protein TerC family
A9E78_RS10745	COG0071	Belongs to the small heat shock protein (HSP20) family
A9E78_RS10755	COG0288	reversible hydration of carbon dioxide
A9E78_RS10825	COG0604	alcohol dehydrogenase
A9E78_RS10855	COG1090	epimerase
A9E78_RS10875	COG4638	Rieske (2fe-2S)
A9E78_RS10890	COG2171	N-acyltransferase activity
A9E78_RS10925	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A9E78_RS10930	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A9E78_RS10940	COG0318	PFAM AMP-dependent synthetase and ligase
A9E78_RS10950	COG1028	Short-chain dehydrogenase reductase Sdr
A9E78_RS10955	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A9E78_RS10960	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A9E78_RS10965	COG2814	Major facilitator Superfamily
A9E78_RS10980	COG1132	(ABC) transporter
A9E78_RS11020	COG1301	dicarboxylic acid transport
A9E78_RS11035	COG0586	Pfam SNARE associated Golgi protein
A9E78_RS11045	COG0519	Catalyzes the synthesis of GMP from XMP
A9E78_RS11060	COG0174	glutamine synthetase
A9E78_RS11080	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
A9E78_RS11095	COG2823	Periplasmic or secreted lipoprotein
A9E78_RS11100	COG3243	poly(R)-hydroxyalkanoic acid synthase
A9E78_RS11110	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
A9E78_RS11170	COG0584	glycerophosphoryl diester phosphodiesterase
A9E78_RS11190	COG3185	4-Hydroxyphenylpyruvate dioxygenase
A9E78_RS11200	COG0625	glutathione transferase activity
A9E78_RS11220	COG1136	(ABC) transporter
A9E78_RS11225	COG4591	ABC-type transport system involved in lipoprotein release permease component
A9E78_RS11235	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
A9E78_RS11265	COG0546	phosphoglycolate phosphatase activity
A9E78_RS11270	COG0564	pseudouridine synthase activity
A9E78_RS11275	COG1530	ribonuclease E activity
A9E78_RS11285	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A9E78_RS11300	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A9E78_RS11310	COG2890	protein-(glutamine-N5) methyltransferase activity
A9E78_RS11315	COG1193	negative regulation of DNA recombination
A9E78_RS11320	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A9E78_RS11330	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
A9E78_RS11335	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
A9E78_RS11375	COG1028	Short-chain dehydrogenase reductase Sdr
A9E78_RS11400	COG0814	amino acid
A9E78_RS11445	COG0142	geranyltranstransferase activity
A9E78_RS11450	COG2226	methyltransferase
A9E78_RS11455	COG1040	competence protein
A9E78_RS11480	COG2890	protein-(glutamine-N5) methyltransferase activity
A9E78_RS11485	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
A9E78_RS11495	COG1519	Transferase
A9E78_RS11500	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
A9E78_RS11510	COG3240	lipase activity
A9E78_RS11525	COG0513	Belongs to the DEAD box helicase family
A9E78_RS11530	COG1597	lipid kinase activity
A9E78_RS11535	COG1902	pentaerythritol trinitrate reductase activity
A9E78_RS11535	COG0446	pyridine nucleotide-disulphide oxidoreductase
A9E78_RS11540	COG2032	superoxide dismutase activity
A9E78_RS11550	COG0450	alkyl hydroperoxide reductase
A9E78_RS11565	COG0494	nUDIX hydrolase
A9E78_RS11570	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A9E78_RS11575	COG0154	amidase activity
A9E78_RS11580	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
A9E78_RS11585	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
A9E78_RS11600	COG0358	DNA primase activity
A9E78_RS11660	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A9E78_RS11700	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
A9E78_RS11705	COG4962	Type ii secretion system protein e
A9E78_RS11720	COG3451	type IV secretory pathway VirB4
A9E78_RS11740	COG2948	multi-organism process
A9E78_RS11755	COG3846	protein secretion by the type IV secretion system
A9E78_RS11765	COG4959	Type IV secretory pathway protease TraF
A9E78_RS11815	COG3436	PFAM IS66 Orf2 family protein
A9E78_RS11850	COG1619	proteins homologs of microcin C7 resistance protein MccF
A9E78_RS11860	COG0542	response to heat
A9E78_RS11865	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A9E78_RS11900	COG3550	peptidyl-serine autophosphorylation
A9E78_RS11905	COG3550	peptidyl-serine autophosphorylation
A9E78_RS11975	COG3550	peptidyl-serine autophosphorylation
A9E78_RS11980	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
A9E78_RS11990	COG0583	DNA-binding transcription factor activity
A9E78_RS11995	COG3158	transport of potassium into the cell
A9E78_RS12015	COG0531	amino acid
A9E78_RS12020	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
A9E78_RS12025	COG0477	Major facilitator Superfamily
A9E78_RS12275	COG0435	Glutathione S-transferase
A9E78_RS12320	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
A9E78_RS12365	COG4565	transcriptional regulatory protein
A9E78_RS12370	COG4251	negative regulation of phosphorylation
A9E78_RS12435	COG0309	Hydrogenase expression formation protein (HypE)
A9E78_RS12450	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
A9E78_RS12470	COG0463	Glycosyl transferase, family 2
A9E78_RS12485	COG0697	spore germination
A9E78_RS12495	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A9E78_RS12500	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
A9E78_RS12510	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A9E78_RS12515	COG0756	dUTP diphosphatase activity
A9E78_RS12520	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
A9E78_RS12525	COG2003	Belongs to the UPF0758 family
A9E78_RS12560	COG5310	Homospermidine synthase
A9E78_RS12565	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
A9E78_RS12595	COG0288	reversible hydration of carbon dioxide
A9E78_RS12600	COG0477	Major facilitator Superfamily
A9E78_RS12625	COG0784	Response regulator, receiver
A9E78_RS12625	COG2205	protein histidine kinase activity
A9E78_RS12635	COG1413	lyase activity
A9E78_RS12640	COG1196	nuclear chromosome segregation
A9E78_RS12660	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A9E78_RS12680	COG1522	sequence-specific DNA binding
A9E78_RS12760	COG0436	Aminotransferase
A9E78_RS12770	COG1959	2 iron, 2 sulfur cluster binding
A9E78_RS12800	COG1970	mechanosensitive ion channel activity
A9E78_RS12840	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A9E78_RS12935	COG2963	transposase activity
A9E78_RS12940	COG2801	Transposase and inactivated derivatives
A9E78_RS12985	COG3189	MarR family transcriptional regulator
A9E78_RS13005	COG1960	acyl-CoA dehydrogenase activity
A9E78_RS13035	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
A9E78_RS13055	COG2027	D-alanyl-D-alanine carboxypeptidase
A9E78_RS13060	COG1475	DNA binding
A9E78_RS13080	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
A9E78_RS13095	COG0758	DNA mediated transformation
A9E78_RS13145	COG3590	peptidase
A9E78_RS13155	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
A9E78_RS13170	COG1181	Belongs to the D-alanine--D-alanine ligase family
A9E78_RS13175	COG0812	UDP-N-acetylmuramate dehydrogenase activity
A9E78_RS13180	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A9E78_RS13185	COG0772	Belongs to the SEDS family
A9E78_RS13190	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
A9E78_RS13195	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A9E78_RS13200	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A9E78_RS13205	COG3115	cell septum assembly
A9E78_RS13210	COG1196	nuclear chromosome segregation
A9E78_RS13235	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
A9E78_RS13245	COG2081	HI0933 family
A9E78_RS13255	COG0795	lipopolysaccharide-transporting ATPase activity
A9E78_RS13260	COG0795	lipopolysaccharide-transporting ATPase activity
A9E78_RS13270	COG2927	DNA polymerase III (CHI subunit)
A9E78_RS13280	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
A9E78_RS13315	COG1376	ErfK ybiS ycfS ynhG family protein
A9E78_RS13335	COG0322	excinuclease ABC activity
A9E78_RS13340	COG2197	response regulator
A9E78_RS13355	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A9E78_RS13375	COG0193	aminoacyl-tRNA hydrolase activity
A9E78_RS13380	COG0012	GTP binding
A9E78_RS13385	COG3300	MHYT domain
A9E78_RS13385	COG5001	Diguanylate cyclase
A9E78_RS13390	COG0142	geranyltranstransferase activity
A9E78_RS13400	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
A9E78_RS13410	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
A9E78_RS13420	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
A9E78_RS13425	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
A9E78_RS13435	COG0439	Biotin carboxylase
A9E78_RS13455	COG2177	Part of the ABC transporter FtsEX involved in
A9E78_RS13460	COG2884	Cell division ATP-binding protein ftsE
A9E78_RS13465	COG0552	protein localization to endoplasmic reticulum
A9E78_RS13470	COG0612	Peptidase, M16
A9E78_RS13475	COG0612	Peptidase, M16
A9E78_RS13480	COG0742	ribosomal rna small subunit methyltransferase
A9E78_RS13500	COG1525	nuclease
A9E78_RS13500	COG0737	Belongs to the 5'-nucleotidase family
A9E78_RS13500	COG4085	toxin activity
A9E78_RS13505	COG2226	methyltransferase
A9E78_RS13510	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A9E78_RS13515	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A9E78_RS13515	COG1181	Belongs to the D-alanine--D-alanine ligase family
A9E78_RS13530	COG0473	3-isopropylmalate dehydrogenase activity
A9E78_RS13530	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
A9E78_RS13570	COG2217	Heavy metal translocating P-type atpase
A9E78_RS13570	COG2608	mercury ion transmembrane transporter activity
A9E78_RS13580	COG2226	methyltransferase
A9E78_RS13590	COG0859	PFAM glycosyl transferase family 9
A9E78_RS13600	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
A9E78_RS13610	COG0860	N-Acetylmuramoyl-L-alanine amidase
A9E78_RS13615	COG0802	atpase or kinase
A9E78_RS13620	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
A9E78_RS13620	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
A9E78_RS13625	COG2969	positive regulation of protein catabolic process
A9E78_RS13630	COG0625	glutathione transferase activity
A9E78_RS13635	COG2857	Cytochrome c1
A9E78_RS13640	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
A9E78_RS13645	COG0723	plastoquinol--plastocyanin reductase activity
A9E78_RS13650	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
A9E78_RS13665	COG0776	regulation of translation
A9E78_RS13670	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A9E78_RS13670	COG0072	phenylalanine-tRNA ligase activity
A9E78_RS13695	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A9E78_RS13720	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
A9E78_RS13740	COG0640	Transcriptional regulator
A9E78_RS13750	COG2860	membrane
A9E78_RS13755	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A9E78_RS13760	COG0343	queuine tRNA-ribosyltransferase activity
A9E78_RS13775	COG0156	8-amino-7-oxononanoate synthase activity
A9E78_RS13795	COG0181	hydroxymethylbilane synthase activity
A9E78_RS13820	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
A9E78_RS13830	COG0617	tRNA 3'-terminal CCA addition
A9E78_RS13875	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
A9E78_RS13880	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
A9E78_RS13885	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
A9E78_RS13920	COG4536	flavin adenine dinucleotide binding
A9E78_RS13925	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
A9E78_RS13930	COG0537	adenosine 5'-monophosphoramidase activity
A9E78_RS13935	COG0302	gtp cyclohydrolase
A9E78_RS13945	COG1185	polyribonucleotide nucleotidyltransferase activity
A9E78_RS13955	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
A9E78_RS13965	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
A9E78_RS13970	COG0195	Participates in both transcription termination and antitermination
A9E78_RS13970	COG2251	uridine kinase activity
A9E78_RS14015	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
A9E78_RS14020	COG1034	ATP synthesis coupled electron transport
A9E78_RS14025	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
A9E78_RS14040	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A9E78_RS14065	COG0149	triose-phosphate isomerase activity
A9E78_RS14080	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
A9E78_RS14095	COG1534	Rna-binding protein
A9E78_RS14115	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
A9E78_RS14125	COG3104	oligopeptide transport
A9E78_RS14140	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A9E78_RS14145	COG0308	aminopeptidase N
A9E78_RS14150	COG2766	serine protein kinase
A9E78_RS14160	COG2719	SpoVR family
A9E78_RS14170	COG2234	aminopeptidase activity
A9E78_RS14180	COG0210	DNA helicase
A9E78_RS14185	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
A9E78_RS14200	COG0667	Aldo Keto reductase
A9E78_RS14205	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
A9E78_RS14210	COG1217	gtp-binding protein TYPA
A9E78_RS14220	COG0497	DNA recombination
A9E78_RS14230	COG0666	response to abiotic stimulus
A9E78_RS14230	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
A9E78_RS14250	COG5113	peptidyl-tyrosine sulfation
A9E78_RS14270	COG2183	response to ionizing radiation
A9E78_RS14275	COG0500	methyltransferase
A9E78_RS14280	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A9E78_RS14290	COG1054	Belongs to the UPF0176 family
A9E78_RS14300	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
A9E78_RS14305	COG0477	Major facilitator Superfamily
A9E78_RS14310	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
A9E78_RS14315	COG0516	GMP reductase activity
A9E78_RS14350	COG1278	Cold shock
A9E78_RS14380	COG2304	oxidoreductase activity
A9E78_RS14395	COG0714	Associated with various cellular activities
A9E78_RS14405	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A9E78_RS14415	COG1028	Short-chain dehydrogenase reductase Sdr
A9E78_RS14430	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
A9E78_RS14445	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
A9E78_RS14450	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
A9E78_RS14455	COG0730	response to heat
A9E78_RS14460	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
A9E78_RS14470	COG0252	asparaginase activity
A9E78_RS14480	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
A9E78_RS14485	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
A9E78_RS14495	COG0598	Magnesium transport protein CorA
A9E78_RS14505	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A9E78_RS14510	COG2878	Part of a membrane complex involved in electron transport
A9E78_RS14515	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A9E78_RS14515	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A9E78_RS14520	COG0163	prenyltransferase activity
A9E78_RS14535	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
A9E78_RS14540	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
A9E78_RS14540	COG0662	Cupin 2, conserved barrel domain protein
A9E78_RS14550	COG0445	tRNA wobble uridine modification
A9E78_RS14555	COG0357	Ribosomal RNA small subunit methyltransferase G
A9E78_RS14560	COG1192	Involved in chromosome partitioning
A9E78_RS14565	COG1475	DNA binding
A9E78_RS14580	COG1845	cytochrome c oxidase, subunit III
A9E78_RS14585	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
A9E78_RS14590	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
A9E78_RS14595	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
A9E78_RS14600	COG2010	Cytochrome c
A9E78_RS14625	COG2226	methyltransferase
A9E78_RS14635	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
A9E78_RS14660	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A9E78_RS14660	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A9E78_RS14735	COG1136	(ABC) transporter
A9E78_RS14735	COG0577	efflux transmembrane transporter activity
A9E78_RS14755	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
A9E78_RS14765	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A9E78_RS14770	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
A9E78_RS14775	COG0805	protein transport
A9E78_RS14790	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A9E78_RS14790	COG0543	2 iron, 2 sulfur cluster binding
A9E78_RS14810	COG1385	rRNA (uridine-N3-)-methyltransferase activity
A9E78_RS14860	COG0776	regulation of translation
A9E78_RS14870	COG0330	HflC and HflK could
A9E78_RS14880	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
A9E78_RS14910	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A9E78_RS14915	COG0450	alkyl hydroperoxide reductase
A9E78_RS14920	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
A9E78_RS14925	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
A9E78_RS14930	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A9E78_RS14935	COG1234	tRNA 3'-trailer cleavage
A9E78_RS14945	COG0281	malic enzyme
A9E78_RS14950	COG0009	L-threonylcarbamoyladenylate synthase
A9E78_RS14960	COG0688	phosphatidylethanolamine metabolic process
A9E78_RS14975	COG3227	Zinc metalloprotease (Elastase)
A9E78_RS15015	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A9E78_RS15030	COG0356	it plays a direct role in the translocation of protons across the membrane
A9E78_RS15045	COG2823	Periplasmic or secreted lipoprotein
A9E78_RS15050	COG2823	Periplasmic or secreted lipoprotein
A9E78_RS15055	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
A9E78_RS15060	COG0792	nuclease activity
A9E78_RS15065	COG3107	peptidoglycan biosynthetic process
A9E78_RS15070	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
A9E78_RS15095	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
A9E78_RS15100	COG0706	membrane insertase activity