locus-tag	class	description
LPL_RS00010	COG0592	DNA-directed DNA polymerase activity
LPL_RS00020	COG0187	DNA topoisomerase II activity
LPL_RS00030	COG1166	arginine decarboxylase activity
LPL_RS00050	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
LPL_RS00055	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LPL_RS00065	COG1741	Belongs to the pirin family
LPL_RS00075	COG1566	PFAM secretion protein HlyD family protein
LPL_RS00100	COG3227	Zinc metalloprotease (Elastase)
LPL_RS00110	COG3028	Belongs to the UPF0307 family
LPL_RS00135	COG0531	amino acid
LPL_RS00140	COG0306	phosphate transporter
LPL_RS00150	COG5001	Diguanylate cyclase
LPL_RS00150	COG3300	MHYT domain
LPL_RS00160	COG2234	aminopeptidase activity
LPL_RS00185	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LPL_RS00210	COG3781	membrane
LPL_RS00255	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
LPL_RS00300	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
LPL_RS00330	COG0582	viral genome integration into host DNA
LPL_RS00375	COG0436	Aminotransferase
LPL_RS00385	COG5001	Diguanylate cyclase
LPL_RS00385	COG3706	GGDEF domain
LPL_RS00385	COG4251	negative regulation of phosphorylation
LPL_RS00385	COG2203	Gaf domain
LPL_RS00390	COG0069	glutamate synthase activity
LPL_RS00395	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
LPL_RS00400	COG3079	Belongs to the UPF0149 family
LPL_RS00405	COG0006	proline dipeptidase activity
LPL_RS00410	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LPL_RS00415	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LPL_RS00430	COG4067	protein conserved in archaea
LPL_RS00430	COG0189	ligase activity
LPL_RS00465	COG0557	exoribonuclease II activity
LPL_RS00470	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LPL_RS00490	COG2824	Alkylphosphonate utilization operon protein PhnA
LPL_RS00515	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LPL_RS00525	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LPL_RS00535	COG2252	PERMEase
LPL_RS00610	COG1116	anion transmembrane transporter activity
LPL_RS00615	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LPL_RS00635	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LPL_RS00680	COG0469	pyruvate kinase activity
LPL_RS00690	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
LPL_RS00695	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
LPL_RS00705	COG0339	signal peptide processing
LPL_RS00745	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
LPL_RS00760	COG3451	type IV secretory pathway VirB4
LPL_RS00790	COG2948	multi-organism process
LPL_RS00825	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LPL_RS00870	COG0582	viral genome integration into host DNA
LPL_RS00880	COG0758	DNA mediated transformation
LPL_RS00900	COG2963	transposase activity
LPL_RS00905	COG2801	Transposase and inactivated derivatives
LPL_RS00955	COG2963	transposase activity
LPL_RS00960	COG2801	Transposase and inactivated derivatives
LPL_RS01020	COG0436	Aminotransferase
LPL_RS01055	COG5001	Diguanylate cyclase
LPL_RS01060	COG2200	EAL domain
LPL_RS01065	COG0024	Methionine aminopeptidase
LPL_RS01110	COG2354	Protein conserved in bacteria
LPL_RS01115	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
LPL_RS01140	COG0583	DNA-binding transcription factor activity
LPL_RS01155	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LPL_RS01160	COG0477	Major facilitator Superfamily
LPL_RS01170	COG2226	methyltransferase
LPL_RS01235	COG1271	oxidase subunit
LPL_RS01240	COG1294	oxidase, subunit
LPL_RS01255	COG1307	EDD domain protein, DegV family
LPL_RS01260	COG1028	Short-chain dehydrogenase reductase Sdr
LPL_RS01265	COG3046	protein related to deoxyribodipyrimidine photolyase
LPL_RS01275	COG2815	serine threonine protein kinase
LPL_RS01275	COG0515	serine threonine protein kinase
LPL_RS01295	COG0415	Belongs to the DNA photolyase family
LPL_RS01300	COG1346	cytolysis
LPL_RS01305	COG1380	Effector of murein hydrolase LrgA
LPL_RS01310	COG0583	DNA-binding transcription factor activity
LPL_RS01345	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
LPL_RS01350	COG0583	DNA-binding transcription factor activity
LPL_RS01355	COG2274	protein secretion by the type I secretion system
LPL_RS01380	COG3706	GGDEF domain
LPL_RS01385	COG2217	Heavy metal translocating P-type atpase
LPL_RS01390	COG0735	belongs to the Fur family
LPL_RS01405	COG1196	nuclear chromosome segregation
LPL_RS01425	COG1012	belongs to the aldehyde dehydrogenase family
LPL_RS01445	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LPL_RS01475	COG1393	Belongs to the ArsC family
LPL_RS01485	COG0513	Belongs to the DEAD box helicase family
LPL_RS01490	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
LPL_RS01515	COG1566	PFAM secretion protein HlyD family protein
LPL_RS01535	COG1573	uracil-dna glycosylase
LPL_RS01540	COG2270	Major facilitator Superfamily
LPL_RS01560	COG0598	Magnesium transport protein CorA
LPL_RS01570	COG0433	COG0433 Predicted ATPase
LPL_RS01575	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
LPL_RS01580	COG1335	isochorismatase
LPL_RS01590	COG2814	Major facilitator Superfamily
LPL_RS01595	COG0583	DNA-binding transcription factor activity
LPL_RS01625	COG0583	DNA-binding transcription factor activity
LPL_RS01635	COG2226	methyltransferase
LPL_RS01655	COG4221	oxidoreductase activity
LPL_RS01670	COG1509	lysine 2,3-aminomutase activity
LPL_RS01705	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
LPL_RS01790	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
LPL_RS01985	COG0629	single-stranded DNA binding
LPL_RS01990	COG2814	Major facilitator Superfamily
LPL_RS01995	COG1028	Short-chain dehydrogenase reductase Sdr
LPL_RS02005	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LPL_RS02010	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LPL_RS02020	COG1560	Kdo2-lipid A biosynthetic process
LPL_RS02045	COG0400	carboxylic ester hydrolase activity
LPL_RS02050	COG2867	negative regulation of translational initiation
LPL_RS02055	COG2914	Belongs to the UPF0125 (RnfH) family
LPL_RS02060	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LPL_RS02065	COG0735	belongs to the Fur family
LPL_RS02070	COG3706	GGDEF domain
LPL_RS02095	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
LPL_RS02130	COG1704	LemA family
LPL_RS02140	COG0842	Transport permease protein
LPL_RS02145	COG1131	(ABC) transporter
LPL_RS02175	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LPL_RS02200	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
LPL_RS02215	COG0531	amino acid
LPL_RS02235	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
LPL_RS02255	COG1612	heme a metabolic process
LPL_RS02265	COG1999	signal sequence binding
LPL_RS02280	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
LPL_RS02285	COG0363	glucosamine-6-phosphate deaminase activity
LPL_RS02290	COG0129	dihydroxy-acid dehydratase activity
LPL_RS02295	COG0837	glucose binding
LPL_RS02300	COG0800	Aldolase
LPL_RS02305	COG2814	Major facilitator Superfamily
LPL_RS02315	COG3655	Transcriptional regulator
LPL_RS02330	COG1278	Cold shock
LPL_RS02350	COG1566	PFAM secretion protein HlyD family protein
LPL_RS02365	COG1733	regulation of RNA biosynthetic process
LPL_RS02480	COG0477	Major facilitator Superfamily
LPL_RS02495	COG0138	bifunctional purine biosynthesis protein purh
LPL_RS02505	COG0439	Biotin carboxylase
LPL_RS02510	COG0511	ligase activity, forming carbon-carbon bonds
LPL_RS02520	COG0511	ligase activity, forming carbon-carbon bonds
LPL_RS02520	COG5016	pyruvate
LPL_RS02525	COG3227	Zinc metalloprotease (Elastase)
LPL_RS02535	COG3568	Endonuclease Exonuclease Phosphatase
LPL_RS02540	COG3588	fructose-bisphosphate aldolase
LPL_RS02560	COG1183	phosphatidylcholine synthase activity
LPL_RS02570	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
LPL_RS02575	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
LPL_RS02595	COG1363	Peptidase, m42
LPL_RS02605	COG0330	HflC and HflK could
LPL_RS02610	COG0330	HflC and HflK could
LPL_RS02625	COG1438	arginine binding
LPL_RS02630	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LPL_RS02635	COG0765	amino acid transport
LPL_RS02640	COG1126	abc transporter atp-binding protein
LPL_RS02655	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
LPL_RS02670	COG0793	Belongs to the peptidase S41A family
LPL_RS02675	COG4942	peptidase
LPL_RS02700	COG0575	Belongs to the CDS family
LPL_RS02720	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LPL_RS02730	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LPL_RS02770	COG0656	L-ascorbic acid biosynthetic process
LPL_RS02790	COG0572	uridine kinase
LPL_RS02800	COG2852	Protein conserved in bacteria
LPL_RS02815	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
LPL_RS02820	COG0589	response to stress
LPL_RS02825	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LPL_RS02825	COG4651	solute:proton antiporter activity
LPL_RS02835	COG2963	transposase activity
LPL_RS02840	COG2801	Transposase and inactivated derivatives
LPL_RS02860	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
LPL_RS02865	COG2009	succinate dehydrogenase
LPL_RS02870	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
LPL_RS02875	COG1053	succinate dehydrogenase
LPL_RS02880	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
LPL_RS02890	COG0508	dehydrogenase complex catalyzes the overall conversion of
LPL_RS02900	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
LPL_RS02920	COG2814	Major facilitator Superfamily
LPL_RS02930	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
LPL_RS02935	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
LPL_RS02945	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
LPL_RS03020	COG1028	Short-chain dehydrogenase reductase Sdr
LPL_RS03025	COG1028	Short-chain dehydrogenase reductase Sdr
LPL_RS03045	COG2715	membrane protein required for spore maturation
LPL_RS03050	COG0700	Nucleoside recognition
LPL_RS03055	COG0739	heme binding
LPL_RS03090	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
LPL_RS03095	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LPL_RS03100	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
LPL_RS03115	COG0306	phosphate transporter
LPL_RS03120	COG1392	Phosphate transport regulator
LPL_RS03150	COG0606	chelatase, subunit chli
LPL_RS03155	COG2960	long-chain fatty acid transporting porin activity
LPL_RS03160	COG0347	Belongs to the P(II) protein family
LPL_RS03165	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
LPL_RS03200	COG3243	poly(R)-hydroxyalkanoic acid synthase
LPL_RS03205	COG1959	2 iron, 2 sulfur cluster binding
LPL_RS03210	COG0719	Fe-S assembly protein
LPL_RS03215	COG0396	ATPase activity
LPL_RS03220	COG0719	Fe-S assembly protein
LPL_RS03225	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
LPL_RS03230	COG0822	iron-sulfur transferase activity
LPL_RS03235	COG2151	metal-sulfur cluster biosynthetic enzyme
LPL_RS03240	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
LPL_RS03245	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
LPL_RS03250	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LPL_RS03260	COG1253	flavin adenine dinucleotide binding
LPL_RS03265	COG1064	alcohol dehydrogenase
LPL_RS03310	COG0519	Catalyzes the synthesis of GMP from XMP
LPL_RS03430	COG1295	ribonuclease BN
LPL_RS03445	COG2852	Protein conserved in bacteria
LPL_RS03450	COG0708	Exodeoxyribonuclease III
LPL_RS03455	COG0708	Exodeoxyribonuclease III
LPL_RS03465	COG0281	malic enzyme
LPL_RS03480	COG0338	D12 class N6 adenine-specific DNA methyltransferase
LPL_RS03485	COG0814	amino acid
LPL_RS03490	COG0814	amino acid
LPL_RS03505	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LPL_RS03510	COG1131	(ABC) transporter
LPL_RS03515	COG0842	Transport permease protein
LPL_RS03520	COG0842	Transport permease protein
LPL_RS03530	COG0741	lytic transglycosylase activity
LPL_RS03535	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
LPL_RS03550	COG3220	belongs to the UPF0276 family
LPL_RS03570	COG4689	acetoacetate decarboxylase
LPL_RS03590	COG3220	belongs to the UPF0276 family
LPL_RS03620	COG1131	(ABC) transporter
LPL_RS03635	COG4232	protein-disulfide reductase activity
LPL_RS03650	COG0783	Belongs to the Dps family
LPL_RS03655	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
LPL_RS03660	COG0187	DNA topoisomerase II activity
LPL_RS03665	COG4172	Belongs to the ABC transporter superfamily
LPL_RS03685	COG0666	response to abiotic stimulus
LPL_RS03685	COG3177	Filamentation induced by cAMP protein fic
LPL_RS03690	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
LPL_RS03695	COG0659	secondary active sulfate transmembrane transporter activity
LPL_RS03705	COG1538	Outer membrane efflux protein
LPL_RS03710	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
LPL_RS03715	COG0156	8-amino-7-oxononanoate synthase activity
LPL_RS03725	COG0488	(ABC) transporter
LPL_RS03775	COG1297	OPT oligopeptide transporter protein
LPL_RS03780	COG0642	Histidine kinase
LPL_RS03800	COG1823	symporter activity
LPL_RS03810	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LPL_RS03815	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LPL_RS03850	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
LPL_RS03855	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
LPL_RS03860	COG0628	permease
LPL_RS03880	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
LPL_RS03880	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LPL_RS03885	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
LPL_RS03895	COG0305	Participates in initiation and elongation during chromosome replication
LPL_RS03935	COG2827	Endonuclease containing a URI domain
LPL_RS03940	COG3104	oligopeptide transport
LPL_RS03955	COG0107	imidazoleglycerol-phosphate synthase activity
LPL_RS03965	COG1083	cytidylyl-transferase
LPL_RS03970	COG2089	acid synthase
LPL_RS03975	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
LPL_RS03985	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
LPL_RS04000	COG1088	dTDP-glucose 4,6-dehydratase activity
LPL_RS04020	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LPL_RS04025	COG2801	Transposase and inactivated derivatives
LPL_RS04070	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LPL_RS04130	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
LPL_RS04130	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
LPL_RS04135	COG2091	lysine biosynthetic process via aminoadipic acid
LPL_RS04155	COG1696	Membrane protein involved in D-alanine export
LPL_RS04160	COG1760	l-serine dehydratase
LPL_RS04170	COG2223	nitrite transmembrane transporter activity
LPL_RS04185	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
LPL_RS04190	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
LPL_RS04200	COG0659	secondary active sulfate transmembrane transporter activity
LPL_RS04205	COG1960	acyl-CoA dehydrogenase activity
LPL_RS04215	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LPL_RS04215	COG0574	Belongs to the PEP-utilizing enzyme family
LPL_RS04220	COG0475	glutathione-regulated potassium exporter activity
LPL_RS04235	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LPL_RS04240	COG1555	photosystem II stabilization
LPL_RS04245	COG1077	Cell shape determining protein MreB Mrl
LPL_RS04250	COG1792	Involved in formation and maintenance of cell shape
LPL_RS04255	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
LPL_RS04260	COG1187	pseudouridine synthase activity
LPL_RS04280	COG0542	response to heat
LPL_RS04300	COG0705	Rhomboid family
LPL_RS04305	COG0739	heme binding
LPL_RS04355	COG0512	Glutamine amidotransferase of anthranilate synthase
LPL_RS04360	COG1137	ATPase activity
LPL_RS04375	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
LPL_RS04385	COG1127	ABC transporter
LPL_RS04390	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LPL_RS04395	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
LPL_RS04410	COG5007	Belongs to the BolA IbaG family
LPL_RS04425	COG1136	(ABC) transporter
LPL_RS04430	COG0577	efflux transmembrane transporter activity
LPL_RS04435	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LPL_RS04455	COG0616	signal peptide processing
LPL_RS04485	COG1138	Cytochrome C-type biogenesis protein
LPL_RS04505	COG3360	Dodecin
LPL_RS04525	COG1960	acyl-CoA dehydrogenase activity
LPL_RS04530	COG1024	Enoyl-CoA hydratase
LPL_RS04535	COG1024	Enoyl-CoA hydratase
LPL_RS04575	COG2340	Cysteine-rich secretory protein family
LPL_RS04585	COG3706	GGDEF domain
LPL_RS04610	COG1472	Belongs to the glycosyl hydrolase 3 family
LPL_RS04615	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
LPL_RS04630	COG0204	Acyl-transferase
LPL_RS04635	COG0626	cystathionine gamma-synthase activity
LPL_RS04680	COG1194	a g-specific adenine glycosylase
LPL_RS04710	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LPL_RS04735	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
LPL_RS04785	COG1994	Peptidase M50
LPL_RS04810	COG0686	Belongs to the AlaDH PNT family
LPL_RS04865	COG0589	response to stress
LPL_RS04870	COG0196	riboflavin kinase activity
LPL_RS04885	COG0800	Aldolase
LPL_RS04900	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
LPL_RS04915	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
LPL_RS04915	COG0674	pyruvate-flavodoxin oxidoreductase activity
LPL_RS04920	COG1013	pyruvate-flavodoxin oxidoreductase activity
LPL_RS04925	COG0670	Belongs to the BI1 family
LPL_RS04930	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LPL_RS04935	COG0312	modulator of DNA gyrase
LPL_RS04940	COG1752	Esterase of the alpha-beta hydrolase superfamily
LPL_RS04945	COG1022	Amp-dependent synthetase and ligase
LPL_RS04950	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
LPL_RS04980	COG0601	transmembrane transport
LPL_RS04985	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LPL_RS05000	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
LPL_RS05030	COG0833	amino acid
LPL_RS05055	COG2135	peptidase activity
LPL_RS05060	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LPL_RS05085	COG0629	single-stranded DNA binding
LPL_RS05270	COG0640	Transcriptional regulator
LPL_RS05275	COG2217	Heavy metal translocating P-type atpase
LPL_RS05300	COG1028	Short-chain dehydrogenase reductase Sdr
LPL_RS05305	COG1278	Cold shock
LPL_RS05320	COG0242	peptide deformylase activity
LPL_RS05345	COG0582	viral genome integration into host DNA
LPL_RS05355	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
LPL_RS05405	COG2963	transposase activity
LPL_RS05410	COG2801	Transposase and inactivated derivatives
LPL_RS05440	COG0582	viral genome integration into host DNA
LPL_RS05490	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LPL_RS05530	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LPL_RS05530	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LPL_RS05560	COG2963	transposase activity
LPL_RS05565	COG2801	Transposase and inactivated derivatives
LPL_RS05605	COG4251	negative regulation of phosphorylation
LPL_RS05645	COG1388	LysM domain
LPL_RS05645	COG0741	lytic transglycosylase activity
LPL_RS05660	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LPL_RS05670	COG4651	solute:proton antiporter activity
LPL_RS05670	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LPL_RS05675	COG0318	PFAM AMP-dependent synthetase and ligase
LPL_RS05680	COG0590	tRNA wobble adenosine to inosine editing
LPL_RS05695	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LPL_RS05700	COG3335	DDE superfamily endonuclease
LPL_RS05710	COG2070	2-Nitropropane dioxygenase
LPL_RS05740	COG1177	transmembrane transport
LPL_RS05745	COG1176	ABC-type spermidine putrescine transport system, permease component I
LPL_RS05775	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
LPL_RS05815	COG1231	oxidoreductase activity
LPL_RS05825	COG3961	Belongs to the TPP enzyme family
LPL_RS05840	COG0697	spore germination
LPL_RS05865	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LPL_RS05890	COG1355	regulation of microtubule-based process
LPL_RS05930	COG4783	chaperone-mediated protein folding
LPL_RS05935	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LPL_RS05935	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LPL_RS05940	COG0307	riboflavin synthase, alpha
LPL_RS05945	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LPL_RS05945	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LPL_RS05970	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
LPL_RS05985	COG2974	May be involved in recombination
LPL_RS06000	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
LPL_RS06005	COG1472	Belongs to the glycosyl hydrolase 3 family
LPL_RS06015	COG0140	phosphoribosyl-ATP diphosphatase activity
LPL_RS06015	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
LPL_RS06020	COG0107	imidazoleglycerol-phosphate synthase activity
LPL_RS06050	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
LPL_RS06065	COG1294	oxidase, subunit
LPL_RS06080	COG1278	Cold shock
LPL_RS06090	COG0442	prolyl-tRNA aminoacylation
LPL_RS06095	COG1846	Transcriptional regulator
LPL_RS06110	COG1280	lysine exporter protein (LysE YggA)
LPL_RS06135	COG1815	bacterial-type flagellum-dependent cell motility
LPL_RS06145	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
LPL_RS06150	COG1749	Flagellar hook protein flgE
LPL_RS06155	COG4787	bacterial-type flagellum-dependent cell motility
LPL_RS06160	COG4786	Flagellar basal body rod
LPL_RS06210	COG0471	metal ion transport
LPL_RS06210	COG3273	potassium ion transport
LPL_RS06220	COG1132	(ABC) transporter
LPL_RS06235	COG0281	malic enzyme
LPL_RS06285	COG0642	Histidine kinase
LPL_RS06300	COG1388	LysM domain
LPL_RS06300	COG0741	lytic transglycosylase activity
LPL_RS06315	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
LPL_RS06345	COG1090	epimerase
LPL_RS06370	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LPL_RS06380	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
LPL_RS06405	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
LPL_RS06410	COG2814	Major facilitator Superfamily
LPL_RS06415	COG2814	Major facilitator Superfamily
LPL_RS06420	COG4264	IucA IucC family
LPL_RS06455	COG1496	oxidoreductase activity
LPL_RS06505	COG0285	dihydrofolate synthase activity
LPL_RS06515	COG1286	toxin biosynthetic process
LPL_RS06540	COG0815	Transfers the fatty acyl group on membrane lipoproteins
LPL_RS06550	COG1012	belongs to the aldehyde dehydrogenase family
LPL_RS06555	COG1250	3-hydroxyacyl-CoA dehydrogenase
LPL_RS06555	COG1024	Enoyl-CoA hydratase
LPL_RS06560	COG0183	Belongs to the thiolase family
LPL_RS06575	COG3156	type II secretion system protein K
LPL_RS06595	COG2165	general secretion pathway protein
LPL_RS06605	COG0174	glutamine synthetase
LPL_RS06620	COG2515	1-aminocyclopropane-1-carboxylate deaminase
LPL_RS06635	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
LPL_RS06645	COG0673	inositol 2-dehydrogenase activity
LPL_RS06655	COG0772	Belongs to the SEDS family
LPL_RS06660	COG0768	penicillin binding
LPL_RS06680	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
LPL_RS06695	COG0300	oxidoreductase activity
LPL_RS06705	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LPL_RS06750	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LPL_RS06755	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
LPL_RS06765	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LPL_RS06770	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LPL_RS06775	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
LPL_RS06785	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
LPL_RS06795	COG0084	hydrolase, TatD family'
LPL_RS06815	COG0463	Glycosyl transferase, family 2
LPL_RS06855	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
LPL_RS06860	COG0372	Belongs to the citrate synthase family
LPL_RS06885	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
LPL_RS06900	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
LPL_RS06920	COG4221	oxidoreductase activity
LPL_RS06945	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
LPL_RS06955	COG0823	Involved in the tonB-independent uptake of proteins
LPL_RS06960	COG2119	membrane
LPL_RS06970	COG0477	Major facilitator Superfamily
LPL_RS06990	COG0247	lactate metabolic process
LPL_RS06990	COG0277	FAD linked oxidase domain protein
LPL_RS07015	COG2217	Heavy metal translocating P-type atpase
LPL_RS07025	COG0429	hydrolase of the alpha beta-hydrolase fold
LPL_RS07050	COG0768	penicillin binding
LPL_RS07065	COG0488	(ABC) transporter
LPL_RS07070	COG1132	(ABC) transporter
LPL_RS07075	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
LPL_RS07075	COG0456	acetyltransferase
LPL_RS07090	COG3335	DDE superfamily endonuclease
LPL_RS07095	COG0789	Transcriptional regulator
LPL_RS07100	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
LPL_RS07120	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
LPL_RS07125	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
LPL_RS07135	COG5654	RES domain protein
LPL_RS07180	COG0183	Belongs to the thiolase family
LPL_RS07185	COG1250	3-hydroxyacyl-CoA dehydrogenase
LPL_RS07185	COG1024	Enoyl-CoA hydratase
LPL_RS07190	COG1388	LysM domain
LPL_RS07190	COG1376	ErfK ybiS ycfS ynhG family protein
LPL_RS07245	COG1183	phosphatidylcholine synthase activity
LPL_RS07250	COG1012	belongs to the aldehyde dehydrogenase family
LPL_RS07255	COG1376	ErfK ybiS ycfS ynhG family protein
LPL_RS07260	COG2902	Dehydrogenase
LPL_RS07265	COG3038	cytochrome b561
LPL_RS07295	COG0824	Thioesterase
LPL_RS07330	COG0352	thiamine-phosphate diphosphorylase activity
LPL_RS07350	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LPL_RS07365	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LPL_RS07370	COG3264	Mechanosensitive ion channel
LPL_RS07370	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
LPL_RS07390	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
LPL_RS07400	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LPL_RS07405	COG0318	PFAM AMP-dependent synthetase and ligase
LPL_RS07410	COG0850	regulation of cytokinetic process
LPL_RS07415	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LPL_RS07445	COG3063	Type IV pilus biogenesis stability protein PilW
LPL_RS07475	COG0589	response to stress
LPL_RS07480	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
LPL_RS07485	COG0617	tRNA 3'-terminal CCA addition
LPL_RS07490	COG0861	Integral membrane protein TerC family
LPL_RS07495	COG1981	membrane
LPL_RS07525	COG0372	Belongs to the citrate synthase family
LPL_RS07555	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
LPL_RS07580	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
LPL_RS07585	COG5001	Diguanylate cyclase
LPL_RS07585	COG4251	negative regulation of phosphorylation
LPL_RS07585	COG3706	GGDEF domain
LPL_RS07585	COG2203	Gaf domain
LPL_RS07595	COG2274	protein secretion by the type I secretion system
LPL_RS07600	COG3034	peptidoglycan biosynthetic process
LPL_RS07610	COG0586	Pfam SNARE associated Golgi protein
LPL_RS07620	COG2921	Belongs to the UPF0250 family
LPL_RS07630	COG1686	Belongs to the peptidase S11 family
LPL_RS07635	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
LPL_RS07640	COG0475	glutathione-regulated potassium exporter activity
LPL_RS07640	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LPL_RS07645	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
LPL_RS07660	COG0508	dehydrogenase complex catalyzes the overall conversion of
LPL_RS07665	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LPL_RS07670	COG0456	acetyltransferase
LPL_RS07690	COG0308	aminopeptidase N
LPL_RS07695	COG1196	nuclear chromosome segregation
LPL_RS07720	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LPL_RS07750	COG1522	sequence-specific DNA binding
LPL_RS07785	COG3264	Mechanosensitive ion channel
LPL_RS07785	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
LPL_RS07815	COG0156	8-amino-7-oxononanoate synthase activity
LPL_RS07825	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
LPL_RS07835	COG2200	EAL domain
LPL_RS07860	COG0494	nUDIX hydrolase
LPL_RS07870	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LPL_RS07875	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
LPL_RS07885	COG0436	Aminotransferase
LPL_RS07895	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LPL_RS07920	COG2801	Transposase and inactivated derivatives
LPL_RS07925	COG2963	transposase activity
LPL_RS07945	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LPL_RS07955	COG2963	transposase activity
LPL_RS07980	COG2814	Major facilitator Superfamily
LPL_RS08005	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
LPL_RS08015	COG0180	Tryptophanyl-tRNA synthetase
LPL_RS08020	COG0009	L-threonylcarbamoyladenylate synthase
LPL_RS08025	COG0613	PHP domain protein
LPL_RS08030	COG1702	phosphate starvation-inducible protein PhoH
LPL_RS08040	COG4535	Mg2 and Co2 transporter CorC
LPL_RS08045	COG0745	RESPONSE REGULATOR receiver
LPL_RS08060	COG0295	cytidine deaminase activity
LPL_RS08065	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
LPL_RS08070	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
LPL_RS08090	COG3038	cytochrome b561
LPL_RS08095	COG2353	YceI-like domain
LPL_RS08115	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LPL_RS08120	COG0673	inositol 2-dehydrogenase activity
LPL_RS08125	COG2814	Major facilitator Superfamily
LPL_RS08145	COG0531	amino acid
LPL_RS08175	COG4953	penicillin-binding protein 1C
LPL_RS08180	COG2373	Large extracellular alpha-helical protein
LPL_RS08220	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
LPL_RS08225	COG0151	Belongs to the GarS family
LPL_RS08245	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
LPL_RS08250	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LPL_RS08265	COG4232	protein-disulfide reductase activity
LPL_RS08270	COG0300	oxidoreductase activity
LPL_RS08285	COG3144	bacterial-type flagellum assembly
LPL_RS08295	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
LPL_RS08300	COG0531	amino acid
LPL_RS08340	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LPL_RS08345	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LPL_RS08355	COG3138	arginine N-succinyltransferase
LPL_RS08465	COG2894	cell division
LPL_RS08475	COG1960	acyl-CoA dehydrogenase activity
LPL_RS08480	COG2267	carboxylic ester hydrolase activity
LPL_RS08490	COG3842	ATPase activity
LPL_RS08495	COG0395	ABC-type sugar transport system, permease component
LPL_RS08500	COG1175	transmembrane transport
LPL_RS08505	COG1063	alcohol dehydrogenase
LPL_RS08510	COG0038	chloride channel
LPL_RS08515	COG0512	Glutamine amidotransferase of anthranilate synthase
LPL_RS08515	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
LPL_RS08520	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LPL_RS08565	COG0316	Belongs to the HesB IscA family
LPL_RS08580	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
LPL_RS08590	COG0616	signal peptide processing
LPL_RS08595	COG0542	response to heat
LPL_RS08610	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LPL_RS08640	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
LPL_RS08650	COG1677	Flagellar hook-basal body complex protein FliE
LPL_RS08665	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
LPL_RS08675	COG1674	ftsk spoiiie
LPL_RS08680	COG0492	ferredoxin-NADP+ reductase activity
LPL_RS08690	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LPL_RS08690	COG0425	Belongs to the sulfur carrier protein TusA family
LPL_RS08700	COG0312	modulator of DNA gyrase
LPL_RS08715	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LPL_RS08715	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
LPL_RS08750	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
LPL_RS08825	COG0583	DNA-binding transcription factor activity
LPL_RS08880	COG2911	Protein conserved in bacteria
LPL_RS08885	COG0113	porphobilinogen synthase activity
LPL_RS08900	COG0527	aspartate kinase activity
LPL_RS08905	COG1074	ATP-dependent DNA helicase activity
LPL_RS08910	COG0489	protein tyrosine kinase activity
LPL_RS08920	COG0583	DNA-binding transcription factor activity
LPL_RS08925	COG2814	Major facilitator Superfamily
LPL_RS08965	COG1960	acyl-CoA dehydrogenase activity
LPL_RS08970	COG0183	Belongs to the thiolase family
LPL_RS08980	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LPL_RS08985	COG1024	Enoyl-CoA hydratase
LPL_RS09000	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LPL_RS09015	COG2011	ABC-type metal ion transport system permease component
LPL_RS09020	COG1464	Belongs to the NlpA lipoprotein family
LPL_RS09035	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
LPL_RS09040	COG0751	glycine-tRNA ligase activity
LPL_RS09055	COG0210	DNA helicase
LPL_RS09075	COG0189	ligase activity
LPL_RS09100	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LPL_RS09110	COG1524	type I phosphodiesterase nucleotide pyrophosphatase
LPL_RS09115	COG0572	uridine kinase
LPL_RS09145	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
LPL_RS09190	COG0488	(ABC) transporter
LPL_RS09215	COG2951	lytic endotransglycosylase activity
LPL_RS09225	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
LPL_RS09270	COG0346	lactoylglutathione lyase activity
LPL_RS09310	COG0657	acetylesterase activity
LPL_RS09330	COG2223	nitrite transmembrane transporter activity
LPL_RS09335	COG0038	chloride channel
LPL_RS09355	COG3012	SEC-C Motif Domain Protein
LPL_RS09365	COG0714	Associated with various cellular activities
LPL_RS09380	COG2850	peptidyl-arginine hydroxylation
LPL_RS09405	COG3101	peptidyl-lysine hydroxylation
LPL_RS09440	COG0205	6-phosphofructokinase activity
LPL_RS09445	COG4969	Belongs to the N-Me-Phe pilin family
LPL_RS09450	COG4969	Belongs to the N-Me-Phe pilin family
LPL_RS09455	COG0271	Belongs to the BolA IbaG family
LPL_RS09460	COG0531	amino acid
LPL_RS09465	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
LPL_RS09480	COG1214	PFAM Peptidase M22, glycoprotease
LPL_RS09485	COG1199	ATP-dependent helicase activity
LPL_RS09490	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
LPL_RS09515	COG2313	pseudouridylate synthase activity
LPL_RS09535	COG0288	reversible hydration of carbon dioxide
LPL_RS09615	COG1250	3-hydroxyacyl-CoA dehydrogenase
LPL_RS09635	COG5212	phosphodiesterase
LPL_RS09665	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
LPL_RS09685	COG4948	Mandelate Racemase Muconate Lactonizing
LPL_RS09725	COG3335	DDE superfamily endonuclease
LPL_RS09780	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LPL_RS09780	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LPL_RS09795	COG0625	glutathione transferase activity
LPL_RS09800	COG1764	response to oxidative stress
LPL_RS09830	COG3774	pathogenesis
LPL_RS09875	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
LPL_RS09885	COG3335	DDE superfamily endonuclease
LPL_RS09910	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
LPL_RS09940	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LPL_RS09945	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LPL_RS09950	COG1862	Preprotein translocase
LPL_RS09955	COG0343	queuine tRNA-ribosyltransferase activity
LPL_RS09970	COG0488	(ABC) transporter
LPL_RS09975	COG3577	Aspartyl protease
LPL_RS09985	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LPL_RS10000	COG1561	YicC-like family, N-terminal region
LPL_RS10050	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
LPL_RS10060	COG0505	Belongs to the CarA family
LPL_RS10080	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
LPL_RS10090	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
LPL_RS10105	COG0628	permease
LPL_RS10145	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
LPL_RS10160	COG0602	queuosine metabolic process
LPL_RS10165	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
LPL_RS10170	COG2885	chlorophyll binding
LPL_RS10175	COG3218	ABC-type transport auxiliary lipoprotein component
LPL_RS10185	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
LPL_RS10190	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LPL_RS10245	COG2801	Transposase and inactivated derivatives
LPL_RS10260	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
LPL_RS10280	COG1278	Cold shock
LPL_RS10285	COG0513	Belongs to the DEAD box helicase family
LPL_RS10330	COG0583	DNA-binding transcription factor activity
LPL_RS10340	COG1196	nuclear chromosome segregation
LPL_RS10400	COG0477	Major facilitator Superfamily
LPL_RS10410	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LPL_RS10430	COG0259	pyridoxamine-phosphate oxidase activity
LPL_RS10435	COG1733	regulation of RNA biosynthetic process
LPL_RS10440	COG1028	Short-chain dehydrogenase reductase Sdr
LPL_RS10495	COG1132	(ABC) transporter
LPL_RS10500	COG1196	nuclear chromosome segregation
LPL_RS10505	COG1196	nuclear chromosome segregation
LPL_RS10510	COG1413	lyase activity
LPL_RS10515	COG1196	nuclear chromosome segregation
LPL_RS10520	COG1196	nuclear chromosome segregation
LPL_RS10630	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LPL_RS10630	COG0300	oxidoreductase activity
LPL_RS10630	COG0318	PFAM AMP-dependent synthetase and ligase
LPL_RS10630	COG1028	Short-chain dehydrogenase reductase Sdr
LPL_RS10630	COG3321	synthase
LPL_RS10635	COG0784	Response regulator, receiver
LPL_RS10635	COG2205	protein histidine kinase activity
LPL_RS10640	COG0784	Response regulator, receiver
LPL_RS10640	COG2198	Histidine kinase
LPL_RS10640	COG5002	protein histidine kinase activity
LPL_RS10645	COG4106	trans-aconitate 2-methyltransferase activity
LPL_RS10670	COG0861	Integral membrane protein TerC family
LPL_RS10695	COG0288	reversible hydration of carbon dioxide
LPL_RS10715	COG3104	oligopeptide transport
LPL_RS10770	COG0604	alcohol dehydrogenase
LPL_RS10800	COG1090	epimerase
LPL_RS10820	COG4638	Rieske (2fe-2S)
LPL_RS10835	COG2171	N-acyltransferase activity
LPL_RS10865	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LPL_RS10880	COG0318	PFAM AMP-dependent synthetase and ligase
LPL_RS10890	COG1028	Short-chain dehydrogenase reductase Sdr
LPL_RS10895	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LPL_RS10900	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LPL_RS10905	COG2814	Major facilitator Superfamily
LPL_RS10920	COG1132	(ABC) transporter
LPL_RS10960	COG1301	dicarboxylic acid transport
LPL_RS10970	COG0586	Pfam SNARE associated Golgi protein
LPL_RS10980	COG0519	Catalyzes the synthesis of GMP from XMP
LPL_RS10995	COG0174	glutamine synthetase
LPL_RS11015	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
LPL_RS11030	COG2823	Periplasmic or secreted lipoprotein
LPL_RS11035	COG3243	poly(R)-hydroxyalkanoic acid synthase
LPL_RS11045	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
LPL_RS11105	COG0584	glycerophosphoryl diester phosphodiesterase
LPL_RS11125	COG3185	4-Hydroxyphenylpyruvate dioxygenase
LPL_RS11135	COG0625	glutathione transferase activity
LPL_RS11160	COG4591	ABC-type transport system involved in lipoprotein release permease component
LPL_RS11185	COG0546	phosphoglycolate phosphatase activity
LPL_RS11190	COG0564	pseudouridine synthase activity
LPL_RS11195	COG1530	ribonuclease E activity
LPL_RS11205	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
LPL_RS11220	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
LPL_RS11230	COG2890	protein-(glutamine-N5) methyltransferase activity
LPL_RS11235	COG1193	negative regulation of DNA recombination
LPL_RS11240	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LPL_RS11295	COG1028	Short-chain dehydrogenase reductase Sdr
LPL_RS11320	COG0814	amino acid
LPL_RS11365	COG0142	geranyltranstransferase activity
LPL_RS11370	COG2226	methyltransferase
LPL_RS11375	COG1040	competence protein
LPL_RS11400	COG2890	protein-(glutamine-N5) methyltransferase activity
LPL_RS11405	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
LPL_RS11415	COG1519	Transferase
LPL_RS11420	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
LPL_RS11430	COG3240	lipase activity
LPL_RS11445	COG0513	Belongs to the DEAD box helicase family
LPL_RS11450	COG1597	lipid kinase activity
LPL_RS11455	COG1902	pentaerythritol trinitrate reductase activity
LPL_RS11455	COG0446	pyridine nucleotide-disulphide oxidoreductase
LPL_RS11465	COG2032	superoxide dismutase activity
LPL_RS11475	COG0450	alkyl hydroperoxide reductase
LPL_RS11490	COG0494	nUDIX hydrolase
LPL_RS11495	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LPL_RS11500	COG0154	amidase activity
LPL_RS11525	COG0358	DNA primase activity
LPL_RS11555	COG3177	Filamentation induced by cAMP protein fic
LPL_RS11570	COG3550	peptidyl-serine autophosphorylation
LPL_RS11575	COG3550	peptidyl-serine autophosphorylation
LPL_RS11645	COG1028	Short-chain dehydrogenase reductase Sdr
LPL_RS11650	COG0589	response to stress
LPL_RS11675	COG0531	amino acid
LPL_RS11685	COG0477	Major facilitator Superfamily
LPL_RS11740	COG0583	DNA-binding transcription factor activity
LPL_RS11925	COG0435	Glutathione S-transferase
LPL_RS11955	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
LPL_RS12000	COG4565	transcriptional regulatory protein
LPL_RS12005	COG4251	negative regulation of phosphorylation
LPL_RS12075	COG0309	Hydrogenase expression formation protein (HypE)
LPL_RS12090	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
LPL_RS12110	COG0463	Glycosyl transferase, family 2
LPL_RS12125	COG0697	spore germination
LPL_RS12135	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LPL_RS12150	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LPL_RS12160	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
LPL_RS12200	COG5310	Homospermidine synthase
LPL_RS12205	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
LPL_RS12240	COG0288	reversible hydration of carbon dioxide
LPL_RS12245	COG0477	Major facilitator Superfamily
LPL_RS12265	COG2205	protein histidine kinase activity
LPL_RS12265	COG0784	Response regulator, receiver
LPL_RS12275	COG1413	lyase activity
LPL_RS12280	COG1196	nuclear chromosome segregation
LPL_RS12300	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LPL_RS12320	COG1522	sequence-specific DNA binding
LPL_RS12380	COG1605	Chorismate mutase
LPL_RS12380	COG0077	Prephenate dehydratase
LPL_RS12390	COG0436	Aminotransferase
LPL_RS12400	COG1959	2 iron, 2 sulfur cluster binding
LPL_RS12455	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LPL_RS12495	COG0515	serine threonine protein kinase
LPL_RS12495	COG2815	serine threonine protein kinase
LPL_RS12505	COG1943	Transposase
LPL_RS12550	COG0582	viral genome integration into host DNA
LPL_RS12615	COG3189	MarR family transcriptional regulator
LPL_RS12635	COG1960	acyl-CoA dehydrogenase activity
LPL_RS12665	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
LPL_RS12685	COG2027	D-alanyl-D-alanine carboxypeptidase
LPL_RS12690	COG1475	DNA binding
LPL_RS12725	COG0758	DNA mediated transformation
LPL_RS12775	COG3590	peptidase
LPL_RS12785	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
LPL_RS12815	COG0772	Belongs to the SEDS family
LPL_RS12830	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LPL_RS12835	COG3115	cell septum assembly
LPL_RS12840	COG1196	nuclear chromosome segregation
LPL_RS12875	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
LPL_RS12885	COG2081	HI0933 family
LPL_RS12895	COG0795	lipopolysaccharide-transporting ATPase activity
LPL_RS12900	COG0795	lipopolysaccharide-transporting ATPase activity
LPL_RS12910	COG2927	DNA polymerase III (CHI subunit)
LPL_RS12920	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
LPL_RS12955	COG1376	ErfK ybiS ycfS ynhG family protein
LPL_RS12980	COG2197	response regulator
LPL_RS13020	COG0012	GTP binding
LPL_RS13025	COG5001	Diguanylate cyclase
LPL_RS13025	COG3300	MHYT domain
LPL_RS13030	COG0142	geranyltranstransferase activity
LPL_RS13050	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
LPL_RS13075	COG0439	Biotin carboxylase
LPL_RS13090	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LPL_RS13095	COG2177	Part of the ABC transporter FtsEX involved in
LPL_RS13100	COG2884	Cell division ATP-binding protein ftsE
LPL_RS13105	COG0552	protein localization to endoplasmic reticulum
LPL_RS13110	COG0612	Peptidase, M16
LPL_RS13115	COG0612	Peptidase, M16
LPL_RS13120	COG0742	ribosomal rna small subunit methyltransferase
LPL_RS13140	COG0737	Belongs to the 5'-nucleotidase family
LPL_RS13140	COG4085	toxin activity
LPL_RS13140	COG1525	nuclease
LPL_RS13145	COG2226	methyltransferase
LPL_RS13150	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LPL_RS13155	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
LPL_RS13155	COG1181	Belongs to the D-alanine--D-alanine ligase family
LPL_RS13170	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
LPL_RS13170	COG0473	3-isopropylmalate dehydrogenase activity
LPL_RS13210	COG2217	Heavy metal translocating P-type atpase
LPL_RS13210	COG2608	mercury ion transmembrane transporter activity
LPL_RS13220	COG2226	methyltransferase
LPL_RS13230	COG0859	PFAM glycosyl transferase family 9
LPL_RS13245	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
LPL_RS13250	COG0860	N-Acetylmuramoyl-L-alanine amidase
LPL_RS13255	COG0802	atpase or kinase
LPL_RS13260	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
LPL_RS13260	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
LPL_RS13265	COG2969	positive regulation of protein catabolic process
LPL_RS13270	COG0625	glutathione transferase activity
LPL_RS13275	COG2857	Cytochrome c1
LPL_RS13280	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
LPL_RS13285	COG0723	plastoquinol--plastocyanin reductase activity
LPL_RS13290	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
LPL_RS13305	COG0776	regulation of translation
LPL_RS13385	COG2860	membrane
LPL_RS13390	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LPL_RS13395	COG0343	queuine tRNA-ribosyltransferase activity
LPL_RS13410	COG0156	8-amino-7-oxononanoate synthase activity
LPL_RS13455	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
LPL_RS13505	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
LPL_RS13550	COG4536	flavin adenine dinucleotide binding
LPL_RS13555	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
LPL_RS13560	COG0537	adenosine 5'-monophosphoramidase activity
LPL_RS13565	COG0302	gtp cyclohydrolase
LPL_RS13600	COG2251	uridine kinase activity
LPL_RS13600	COG0195	Participates in both transcription termination and antitermination
LPL_RS13650	COG1034	ATP synthesis coupled electron transport
LPL_RS13655	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
LPL_RS13710	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
LPL_RS13725	COG1534	Rna-binding protein
LPL_RS13745	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
LPL_RS13755	COG3104	oligopeptide transport
LPL_RS13775	COG0308	aminopeptidase N
LPL_RS13780	COG2766	serine protein kinase
LPL_RS13790	COG2719	SpoVR family
LPL_RS13800	COG2234	aminopeptidase activity
LPL_RS13810	COG0210	DNA helicase
LPL_RS13815	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
LPL_RS13835	COG1217	gtp-binding protein TYPA
LPL_RS13845	COG0497	DNA recombination
LPL_RS13855	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
LPL_RS13855	COG0666	response to abiotic stimulus
LPL_RS13885	COG2183	response to ionizing radiation
LPL_RS13915	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
LPL_RS13920	COG0477	Major facilitator Superfamily
LPL_RS13925	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
LPL_RS13930	COG0516	GMP reductase activity
LPL_RS13965	COG1278	Cold shock
LPL_RS13995	COG2304	oxidoreductase activity
LPL_RS14010	COG0714	Associated with various cellular activities
LPL_RS14045	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
LPL_RS14070	COG0730	response to heat
LPL_RS14075	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
LPL_RS14085	COG0252	asparaginase activity
LPL_RS14100	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
LPL_RS14110	COG0598	Magnesium transport protein CorA
LPL_RS14120	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
LPL_RS14125	COG2878	Part of a membrane complex involved in electron transport
LPL_RS14135	COG0163	prenyltransferase activity
LPL_RS14155	COG0662	Cupin 2, conserved barrel domain protein
LPL_RS14155	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
LPL_RS14175	COG1192	Involved in chromosome partitioning
LPL_RS14180	COG1475	DNA binding
LPL_RS14195	COG1845	cytochrome c oxidase, subunit III
LPL_RS14200	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
LPL_RS14205	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LPL_RS14210	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
LPL_RS14215	COG2010	Cytochrome c
LPL_RS14250	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
LPL_RS14275	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LPL_RS14275	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LPL_RS14280	COG2199	diguanylate cyclase activity
LPL_RS14440	COG0805	protein transport
LPL_RS14455	COG0543	2 iron, 2 sulfur cluster binding
LPL_RS14455	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LPL_RS14475	COG1385	rRNA (uridine-N3-)-methyltransferase activity
LPL_RS14495	COG3335	DDE superfamily endonuclease
LPL_RS14500	COG1560	Kdo2-lipid A biosynthetic process
LPL_RS14520	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LPL_RS14570	COG0776	regulation of translation
LPL_RS14580	COG0330	HflC and HflK could
LPL_RS14620	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LPL_RS14625	COG0450	alkyl hydroperoxide reductase
LPL_RS14630	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
LPL_RS14635	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
LPL_RS14640	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LPL_RS14645	COG1234	tRNA 3'-trailer cleavage
LPL_RS14655	COG0281	malic enzyme
LPL_RS14660	COG0009	L-threonylcarbamoyladenylate synthase
LPL_RS14685	COG3227	Zinc metalloprotease (Elastase)
LPL_RS14735	COG0356	it plays a direct role in the translocation of protons across the membrane
LPL_RS14750	COG2823	Periplasmic or secreted lipoprotein
LPL_RS14755	COG2823	Periplasmic or secreted lipoprotein
LPL_RS14760	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
LPL_RS14765	COG0792	nuclease activity
LPL_RS14770	COG3107	peptidoglycan biosynthetic process
LPL_RS14775	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
LPL_RS14890	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
LPL_RS14895	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
LPL_RS15105	COG3335	DDE superfamily endonuclease
LPL_RS15120	COG0484	heat shock protein binding