locus-tag	class	description
LPE509_RS00045	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
LPE509_RS00050	COG3107	peptidoglycan biosynthetic process
LPE509_RS00060	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
LPE509_RS00065	COG2823	Periplasmic or secreted lipoprotein
LPE509_RS00070	COG2823	Periplasmic or secreted lipoprotein
LPE509_RS00085	COG0356	it plays a direct role in the translocation of protons across the membrane
LPE509_RS00135	COG3227	Zinc metalloprotease (Elastase)
LPE509_RS00160	COG0009	L-threonylcarbamoyladenylate synthase
LPE509_RS00165	COG0281	malic enzyme
LPE509_RS00175	COG1234	tRNA 3'-trailer cleavage
LPE509_RS00180	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LPE509_RS00185	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
LPE509_RS00190	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
LPE509_RS00195	COG0450	alkyl hydroperoxide reductase
LPE509_RS00200	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LPE509_RS00225	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
LPE509_RS00235	COG0330	HflC and HflK could
LPE509_RS00245	COG0776	regulation of translation
LPE509_RS00300	COG1132	(ABC) transporter
LPE509_RS00310	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LPE509_RS00315	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LPE509_RS00320	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LPE509_RS00335	COG1560	Kdo2-lipid A biosynthetic process
LPE509_RS00355	COG1385	rRNA (uridine-N3-)-methyltransferase activity
LPE509_RS00370	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
LPE509_RS00375	COG0543	2 iron, 2 sulfur cluster binding
LPE509_RS00375	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LPE509_RS00390	COG0805	protein transport
LPE509_RS00395	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
LPE509_RS00400	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
LPE509_RS00410	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
LPE509_RS00430	COG0577	efflux transmembrane transporter activity
LPE509_RS00430	COG1136	(ABC) transporter
LPE509_RS00510	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LPE509_RS00510	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LPE509_RS00535	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
LPE509_RS00545	COG2226	methyltransferase
LPE509_RS00570	COG2010	Cytochrome c
LPE509_RS00575	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
LPE509_RS00580	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LPE509_RS00585	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
LPE509_RS00590	COG1845	cytochrome c oxidase, subunit III
LPE509_RS00605	COG1475	DNA binding
LPE509_RS00610	COG1192	Involved in chromosome partitioning
LPE509_RS00615	COG0357	Ribosomal RNA small subunit methyltransferase G
LPE509_RS00620	COG0445	tRNA wobble uridine modification
LPE509_RS00630	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
LPE509_RS00630	COG0662	Cupin 2, conserved barrel domain protein
LPE509_RS00635	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
LPE509_RS00650	COG0163	prenyltransferase activity
LPE509_RS00655	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LPE509_RS00655	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LPE509_RS00660	COG2878	Part of a membrane complex involved in electron transport
LPE509_RS00665	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
LPE509_RS00675	COG0598	Magnesium transport protein CorA
LPE509_RS00685	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
LPE509_RS00690	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
LPE509_RS00700	COG0252	asparaginase activity
LPE509_RS00710	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
LPE509_RS00715	COG0730	response to heat
LPE509_RS00720	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
LPE509_RS00725	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
LPE509_RS00740	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
LPE509_RS00755	COG1028	Short-chain dehydrogenase reductase Sdr
LPE509_RS00765	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LPE509_RS00775	COG0714	Associated with various cellular activities
LPE509_RS00790	COG2304	oxidoreductase activity
LPE509_RS00820	COG1278	Cold shock
LPE509_RS00855	COG0516	GMP reductase activity
LPE509_RS00860	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
LPE509_RS00865	COG0477	Major facilitator Superfamily
LPE509_RS00870	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
LPE509_RS00880	COG1054	Belongs to the UPF0176 family
LPE509_RS00890	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LPE509_RS00895	COG0500	methyltransferase
LPE509_RS00900	COG2183	response to ionizing radiation
LPE509_RS00920	COG5113	peptidyl-tyrosine sulfation
LPE509_RS00940	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
LPE509_RS00940	COG0666	response to abiotic stimulus
LPE509_RS00950	COG0497	DNA recombination
LPE509_RS00960	COG1217	gtp-binding protein TYPA
LPE509_RS00965	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
LPE509_RS00970	COG0667	Aldo Keto reductase
LPE509_RS00985	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
LPE509_RS00990	COG0210	DNA helicase
LPE509_RS01000	COG2234	aminopeptidase activity
LPE509_RS01010	COG2719	SpoVR family
LPE509_RS01020	COG2766	serine protein kinase
LPE509_RS01025	COG0308	aminopeptidase N
LPE509_RS01030	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
LPE509_RS01045	COG3104	oligopeptide transport
LPE509_RS01055	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
LPE509_RS01075	COG1534	Rna-binding protein
LPE509_RS01090	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
LPE509_RS01105	COG0149	triose-phosphate isomerase activity
LPE509_RS01130	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LPE509_RS01145	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
LPE509_RS01150	COG1034	ATP synthesis coupled electron transport
LPE509_RS01155	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
LPE509_RS01200	COG2251	uridine kinase activity
LPE509_RS01200	COG0195	Participates in both transcription termination and antitermination
LPE509_RS01205	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
LPE509_RS01215	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
LPE509_RS01225	COG1185	polyribonucleotide nucleotidyltransferase activity
LPE509_RS01235	COG0302	gtp cyclohydrolase
LPE509_RS01240	COG0537	adenosine 5'-monophosphoramidase activity
LPE509_RS01245	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
LPE509_RS01250	COG4536	flavin adenine dinucleotide binding
LPE509_RS01285	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
LPE509_RS01290	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
LPE509_RS01295	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
LPE509_RS01335	COG0617	tRNA 3'-terminal CCA addition
LPE509_RS01345	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
LPE509_RS01370	COG0181	hydroxymethylbilane synthase activity
LPE509_RS01390	COG0156	8-amino-7-oxononanoate synthase activity
LPE509_RS01405	COG0343	queuine tRNA-ribosyltransferase activity
LPE509_RS01410	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LPE509_RS01415	COG2860	membrane
LPE509_RS01425	COG0640	Transcriptional regulator
LPE509_RS01445	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
LPE509_RS01470	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
LPE509_RS01495	COG0072	phenylalanine-tRNA ligase activity
LPE509_RS01495	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LPE509_RS01500	COG0776	regulation of translation
LPE509_RS01515	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
LPE509_RS01520	COG0723	plastoquinol--plastocyanin reductase activity
LPE509_RS01525	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
LPE509_RS01530	COG2857	Cytochrome c1
LPE509_RS01535	COG0625	glutathione transferase activity
LPE509_RS01540	COG2969	positive regulation of protein catabolic process
LPE509_RS01545	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
LPE509_RS01545	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
LPE509_RS01550	COG0802	atpase or kinase
LPE509_RS01555	COG0860	N-Acetylmuramoyl-L-alanine amidase
LPE509_RS01565	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
LPE509_RS01575	COG0859	PFAM glycosyl transferase family 9
LPE509_RS01585	COG2226	methyltransferase
LPE509_RS01595	COG2217	Heavy metal translocating P-type atpase
LPE509_RS01595	COG2608	mercury ion transmembrane transporter activity
LPE509_RS01635	COG0473	3-isopropylmalate dehydrogenase activity
LPE509_RS01635	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
LPE509_RS01650	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
LPE509_RS01650	COG1181	Belongs to the D-alanine--D-alanine ligase family
LPE509_RS01655	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LPE509_RS01660	COG2226	methyltransferase
LPE509_RS01665	COG1525	nuclease
LPE509_RS01665	COG0737	Belongs to the 5'-nucleotidase family
LPE509_RS01665	COG4085	toxin activity
LPE509_RS01685	COG0742	ribosomal rna small subunit methyltransferase
LPE509_RS01690	COG0612	Peptidase, M16
LPE509_RS01695	COG0612	Peptidase, M16
LPE509_RS01700	COG0552	protein localization to endoplasmic reticulum
LPE509_RS01705	COG2884	Cell division ATP-binding protein ftsE
LPE509_RS01710	COG2177	Part of the ABC transporter FtsEX involved in
LPE509_RS01730	COG0439	Biotin carboxylase
LPE509_RS01740	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
LPE509_RS01745	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
LPE509_RS01755	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
LPE509_RS01765	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
LPE509_RS01775	COG0142	geranyltranstransferase activity
LPE509_RS01780	COG3300	MHYT domain
LPE509_RS01780	COG5001	Diguanylate cyclase
LPE509_RS01785	COG0012	GTP binding
LPE509_RS01790	COG0193	aminoacyl-tRNA hydrolase activity
LPE509_RS01810	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
LPE509_RS01825	COG2197	response regulator
LPE509_RS01830	COG0322	excinuclease ABC activity
LPE509_RS01850	COG1376	ErfK ybiS ycfS ynhG family protein
LPE509_RS01885	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
LPE509_RS01895	COG2927	DNA polymerase III (CHI subunit)
LPE509_RS01905	COG0795	lipopolysaccharide-transporting ATPase activity
LPE509_RS01910	COG0795	lipopolysaccharide-transporting ATPase activity
LPE509_RS01920	COG2081	HI0933 family
LPE509_RS01930	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
LPE509_RS01955	COG1196	nuclear chromosome segregation
LPE509_RS01960	COG3115	cell septum assembly
LPE509_RS01965	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LPE509_RS01970	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LPE509_RS01975	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
LPE509_RS01980	COG0772	Belongs to the SEDS family
LPE509_RS01985	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LPE509_RS01990	COG0812	UDP-N-acetylmuramate dehydrogenase activity
LPE509_RS01995	COG1181	Belongs to the D-alanine--D-alanine ligase family
LPE509_RS02010	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
LPE509_RS02020	COG3590	peptidase
LPE509_RS02070	COG0758	DNA mediated transformation
LPE509_RS02085	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
LPE509_RS02105	COG1475	DNA binding
LPE509_RS02110	COG2027	D-alanyl-D-alanine carboxypeptidase
LPE509_RS02130	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
LPE509_RS02160	COG1960	acyl-CoA dehydrogenase activity
LPE509_RS02180	COG3189	MarR family transcriptional regulator
LPE509_RS02225	COG2801	Transposase and inactivated derivatives
LPE509_RS02230	COG2963	transposase activity
LPE509_RS02325	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LPE509_RS02360	COG1970	mechanosensitive ion channel activity
LPE509_RS02390	COG1959	2 iron, 2 sulfur cluster binding
LPE509_RS02400	COG0436	Aminotransferase
LPE509_RS02480	COG1522	sequence-specific DNA binding
LPE509_RS02500	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LPE509_RS02520	COG1196	nuclear chromosome segregation
LPE509_RS02525	COG1413	lyase activity
LPE509_RS02535	COG0784	Response regulator, receiver
LPE509_RS02535	COG2205	protein histidine kinase activity
LPE509_RS02560	COG0477	Major facilitator Superfamily
LPE509_RS02565	COG0288	reversible hydration of carbon dioxide
LPE509_RS02595	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
LPE509_RS02600	COG5310	Homospermidine synthase
LPE509_RS02635	COG2003	Belongs to the UPF0758 family
LPE509_RS02640	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
LPE509_RS02645	COG0756	dUTP diphosphatase activity
LPE509_RS02650	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LPE509_RS02660	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
LPE509_RS02665	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LPE509_RS02675	COG0697	spore germination
LPE509_RS02690	COG0463	Glycosyl transferase, family 2
LPE509_RS02710	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
LPE509_RS02725	COG0309	Hydrogenase expression formation protein (HypE)
LPE509_RS02790	COG4251	negative regulation of phosphorylation
LPE509_RS02795	COG4565	transcriptional regulatory protein
LPE509_RS02840	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
LPE509_RS02885	COG0435	Glutathione S-transferase
LPE509_RS03135	COG0477	Major facilitator Superfamily
LPE509_RS03140	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
LPE509_RS03145	COG0531	amino acid
LPE509_RS03165	COG3158	transport of potassium into the cell
LPE509_RS03170	COG0583	DNA-binding transcription factor activity
LPE509_RS03185	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
LPE509_RS03190	COG3550	peptidyl-serine autophosphorylation
LPE509_RS03260	COG3550	peptidyl-serine autophosphorylation
LPE509_RS03265	COG3550	peptidyl-serine autophosphorylation
LPE509_RS03310	COG0358	DNA primase activity
LPE509_RS03325	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
LPE509_RS03330	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
LPE509_RS03335	COG0154	amidase activity
LPE509_RS03340	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LPE509_RS03345	COG0494	nUDIX hydrolase
LPE509_RS03360	COG0450	alkyl hydroperoxide reductase
LPE509_RS03370	COG2032	superoxide dismutase activity
LPE509_RS03375	COG1902	pentaerythritol trinitrate reductase activity
LPE509_RS03375	COG0446	pyridine nucleotide-disulphide oxidoreductase
LPE509_RS03380	COG1597	lipid kinase activity
LPE509_RS03385	COG0513	Belongs to the DEAD box helicase family
LPE509_RS03400	COG3240	lipase activity
LPE509_RS03410	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
LPE509_RS03415	COG1519	Transferase
LPE509_RS03425	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
LPE509_RS03430	COG2890	protein-(glutamine-N5) methyltransferase activity
LPE509_RS03455	COG1040	competence protein
LPE509_RS03460	COG2226	methyltransferase
LPE509_RS03465	COG0142	geranyltranstransferase activity
LPE509_RS03510	COG0814	amino acid
LPE509_RS03535	COG1028	Short-chain dehydrogenase reductase Sdr
LPE509_RS03580	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
LPE509_RS03585	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
LPE509_RS03595	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LPE509_RS03600	COG1193	negative regulation of DNA recombination
LPE509_RS03605	COG2890	protein-(glutamine-N5) methyltransferase activity
LPE509_RS03615	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
LPE509_RS03630	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
LPE509_RS03640	COG1530	ribonuclease E activity
LPE509_RS03645	COG0564	pseudouridine synthase activity
LPE509_RS03650	COG0546	phosphoglycolate phosphatase activity
LPE509_RS03680	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
LPE509_RS03690	COG4591	ABC-type transport system involved in lipoprotein release permease component
LPE509_RS03695	COG1136	(ABC) transporter
LPE509_RS03715	COG0625	glutathione transferase activity
LPE509_RS03725	COG3185	4-Hydroxyphenylpyruvate dioxygenase
LPE509_RS03745	COG0584	glycerophosphoryl diester phosphodiesterase
LPE509_RS03805	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
LPE509_RS03815	COG3243	poly(R)-hydroxyalkanoic acid synthase
LPE509_RS03820	COG2823	Periplasmic or secreted lipoprotein
LPE509_RS03835	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
LPE509_RS03855	COG0174	glutamine synthetase
LPE509_RS03870	COG0519	Catalyzes the synthesis of GMP from XMP
LPE509_RS03880	COG0586	Pfam SNARE associated Golgi protein
LPE509_RS03895	COG1301	dicarboxylic acid transport
LPE509_RS03935	COG1132	(ABC) transporter
LPE509_RS03950	COG2814	Major facilitator Superfamily
LPE509_RS03955	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LPE509_RS03960	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LPE509_RS03965	COG1028	Short-chain dehydrogenase reductase Sdr
LPE509_RS03975	COG0318	PFAM AMP-dependent synthetase and ligase
LPE509_RS03985	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LPE509_RS03990	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LPE509_RS04025	COG2171	N-acyltransferase activity
LPE509_RS04040	COG4638	Rieske (2fe-2S)
LPE509_RS04060	COG1090	epimerase
LPE509_RS04090	COG0604	alcohol dehydrogenase
LPE509_RS04160	COG0288	reversible hydration of carbon dioxide
LPE509_RS04170	COG0071	Belongs to the small heat shock protein (HSP20) family
LPE509_RS04185	COG0861	Integral membrane protein TerC family
LPE509_RS04210	COG4106	trans-aconitate 2-methyltransferase activity
LPE509_RS04215	COG5002	protein histidine kinase activity
LPE509_RS04215	COG2198	Histidine kinase
LPE509_RS04215	COG0784	Response regulator, receiver
LPE509_RS04220	COG0784	Response regulator, receiver
LPE509_RS04220	COG2205	protein histidine kinase activity
LPE509_RS04225	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LPE509_RS04240	COG0076	glutamate decarboxylase activity
LPE509_RS04260	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
LPE509_RS04305	COG4977	sequence-specific DNA binding
LPE509_RS04335	COG1196	nuclear chromosome segregation
LPE509_RS04340	COG1196	nuclear chromosome segregation
LPE509_RS04345	COG1413	lyase activity
LPE509_RS04350	COG1196	nuclear chromosome segregation
LPE509_RS04355	COG1196	nuclear chromosome segregation
LPE509_RS04360	COG1132	(ABC) transporter
LPE509_RS04415	COG1028	Short-chain dehydrogenase reductase Sdr
LPE509_RS04420	COG1733	regulation of RNA biosynthetic process
LPE509_RS04425	COG0259	pyridoxamine-phosphate oxidase activity
LPE509_RS04445	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LPE509_RS04455	COG0477	Major facilitator Superfamily
LPE509_RS04490	COG3158	transport of potassium into the cell
LPE509_RS04510	COG0513	Belongs to the DEAD box helicase family
LPE509_RS04515	COG1278	Cold shock
LPE509_RS04560	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LPE509_RS04560	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LPE509_RS04585	COG3220	belongs to the UPF0276 family
LPE509_RS04605	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LPE509_RS04615	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LPE509_RS04615	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LPE509_RS04620	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LPE509_RS04620	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LPE509_RS04645	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
LPE509_RS04770	COG3344	reverse transcriptase
LPE509_RS04795	COG0656	L-ascorbic acid biosynthetic process
LPE509_RS04800	COG5265	(ABC) transporter
LPE509_RS04805	COG5265	(ABC) transporter
LPE509_RS04850	COG0582	viral genome integration into host DNA
LPE509_RS04910	COG4959	Type IV secretory pathway protease TraF
LPE509_RS04920	COG3846	protein secretion by the type IV secretion system
LPE509_RS04935	COG2948	multi-organism process
LPE509_RS04955	COG3451	type IV secretory pathway VirB4
LPE509_RS04970	COG4962	Type ii secretion system protein e
LPE509_RS04975	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
LPE509_RS05000	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
LPE509_RS05020	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
LPE509_RS05030	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
LPE509_RS05035	COG2217	Heavy metal translocating P-type atpase
LPE509_RS05055	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LPE509_RS05085	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
LPE509_RS05090	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
LPE509_RS05125	COG2217	Heavy metal translocating P-type atpase
LPE509_RS05150	COG1028	Short-chain dehydrogenase reductase Sdr
LPE509_RS05190	COG0582	viral genome integration into host DNA
LPE509_RS05220	COG1304	FMN binding
LPE509_RS05240	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LPE509_RS05245	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
LPE509_RS05255	COG3218	ABC-type transport auxiliary lipoprotein component
LPE509_RS05260	COG2885	chlorophyll binding
LPE509_RS05265	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
LPE509_RS05285	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
LPE509_RS05290	COG0148	phosphopyruvate hydratase activity
LPE509_RS05295	COG0424	maF-like protein
LPE509_RS05320	COG0628	permease
LPE509_RS05325	COG0018	arginyl-trna synthetase
LPE509_RS05335	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
LPE509_RS05340	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
LPE509_RS05345	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
LPE509_RS05355	COG0443	Heat shock 70 kDa protein
LPE509_RS05365	COG0505	Belongs to the CarA family
LPE509_RS05370	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
LPE509_RS05375	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
LPE509_RS05425	COG1561	YicC-like family, N-terminal region
LPE509_RS05430	COG0194	GDP metabolic process
LPE509_RS05440	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LPE509_RS05450	COG3577	Aspartyl protease
LPE509_RS05455	COG0488	(ABC) transporter
LPE509_RS05465	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
LPE509_RS05470	COG0343	queuine tRNA-ribosyltransferase activity
LPE509_RS05475	COG1862	Preprotein translocase
LPE509_RS05480	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LPE509_RS05485	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LPE509_RS05495	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LPE509_RS05515	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
LPE509_RS05545	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
LPE509_RS05595	COG3774	pathogenesis
LPE509_RS05635	COG1764	response to oxidative stress
LPE509_RS05640	COG0625	glutathione transferase activity
LPE509_RS05720	COG4948	Mandelate Racemase Muconate Lactonizing
LPE509_RS05740	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
LPE509_RS05775	COG5212	phosphodiesterase
LPE509_RS05790	COG1250	3-hydroxyacyl-CoA dehydrogenase
LPE509_RS05830	COG3550	peptidyl-serine autophosphorylation
LPE509_RS05865	COG2313	pseudouridylate synthase activity
LPE509_RS05890	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
LPE509_RS05895	COG1199	ATP-dependent helicase activity
LPE509_RS05900	COG1214	PFAM Peptidase M22, glycoprotease
LPE509_RS05910	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
LPE509_RS05915	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
LPE509_RS05920	COG0531	amino acid
LPE509_RS05930	COG4969	Belongs to the N-Me-Phe pilin family
LPE509_RS05935	COG4969	Belongs to the N-Me-Phe pilin family
LPE509_RS05940	COG0205	6-phosphofructokinase activity
LPE509_RS05950	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LPE509_RS05965	COG0625	glutathione transferase activity
LPE509_RS05975	COG3101	peptidyl-lysine hydroxylation
LPE509_RS06000	COG2850	peptidyl-arginine hydroxylation
LPE509_RS06015	COG0714	Associated with various cellular activities
LPE509_RS06025	COG3012	SEC-C Motif Domain Protein
LPE509_RS06035	COG0038	chloride channel
LPE509_RS06040	COG2223	nitrite transmembrane transporter activity
LPE509_RS06060	COG0657	acetylesterase activity
LPE509_RS06075	COG1254	Belongs to the acylphosphatase family
LPE509_RS06095	COG0346	lactoylglutathione lyase activity
LPE509_RS06130	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
LPE509_RS06140	COG2951	lytic endotransglycosylase activity
LPE509_RS06160	COG0571	ribonuclease III activity
LPE509_RS06165	COG0488	(ABC) transporter
LPE509_RS06205	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
LPE509_RS06210	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
LPE509_RS06240	COG0572	uridine kinase
LPE509_RS06245	COG1524	type I phosphodiesterase nucleotide pyrophosphatase
LPE509_RS06255	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LPE509_RS06275	COG0189	ligase activity
LPE509_RS06295	COG0210	DNA helicase
LPE509_RS06310	COG0751	glycine-tRNA ligase activity
LPE509_RS06315	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
LPE509_RS06320	COG0742	ribosomal rna small subunit methyltransferase
LPE509_RS06330	COG1464	Belongs to the NlpA lipoprotein family
LPE509_RS06335	COG2011	ABC-type metal ion transport system permease component
LPE509_RS06340	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
LPE509_RS06350	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LPE509_RS06365	COG1024	Enoyl-CoA hydratase
LPE509_RS06370	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LPE509_RS06380	COG0183	Belongs to the thiolase family
LPE509_RS06385	COG1960	acyl-CoA dehydrogenase activity
LPE509_RS06410	COG1132	(ABC) transporter
LPE509_RS06425	COG2814	Major facilitator Superfamily
LPE509_RS06430	COG0583	DNA-binding transcription factor activity
LPE509_RS06440	COG0489	protein tyrosine kinase activity
LPE509_RS06450	COG0527	aspartate kinase activity
LPE509_RS06465	COG0113	porphobilinogen synthase activity
LPE509_RS06470	COG2911	Protein conserved in bacteria
LPE509_RS06535	COG0583	DNA-binding transcription factor activity
LPE509_RS06610	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
LPE509_RS06645	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LPE509_RS06645	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
LPE509_RS06660	COG0312	modulator of DNA gyrase
LPE509_RS06670	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LPE509_RS06670	COG0425	Belongs to the sulfur carrier protein TusA family
LPE509_RS06680	COG0492	ferredoxin-NADP+ reductase activity
LPE509_RS06685	COG1674	ftsk spoiiie
LPE509_RS06695	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
LPE509_RS06710	COG1677	Flagellar hook-basal body complex protein FliE
LPE509_RS06720	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
LPE509_RS06740	COG3164	Protein of unknown function
LPE509_RS06750	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LPE509_RS06765	COG0542	response to heat
LPE509_RS06770	COG0616	signal peptide processing
LPE509_RS06780	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
LPE509_RS06785	COG1104	cysteine desulfurase activity
LPE509_RS06795	COG0316	Belongs to the HesB IscA family
LPE509_RS06825	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LPE509_RS06830	COG0154	amidase activity
LPE509_RS06835	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LPE509_RS06840	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
LPE509_RS06840	COG0512	Glutamine amidotransferase of anthranilate synthase
LPE509_RS06845	COG0038	chloride channel
LPE509_RS06850	COG1063	alcohol dehydrogenase
LPE509_RS06855	COG1175	transmembrane transport
LPE509_RS06860	COG0395	ABC-type sugar transport system, permease component
LPE509_RS06875	COG2267	carboxylic ester hydrolase activity
LPE509_RS06880	COG1960	acyl-CoA dehydrogenase activity
LPE509_RS06890	COG2894	cell division
LPE509_RS06900	COG0519	Catalyzes the synthesis of GMP from XMP
LPE509_RS06900	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LPE509_RS06910	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
LPE509_RS06940	COG0052	Belongs to the universal ribosomal protein uS2 family
LPE509_RS06950	COG0528	UMP kinase activity
LPE509_RS06980	COG3138	arginine N-succinyltransferase
LPE509_RS06990	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LPE509_RS06995	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LPE509_RS07035	COG3335	DDE superfamily endonuclease
LPE509_RS07045	COG0531	amino acid
LPE509_RS07050	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
LPE509_RS07060	COG3144	bacterial-type flagellum assembly
LPE509_RS07090	COG0300	oxidoreductase activity
LPE509_RS07095	COG4232	protein-disulfide reductase activity
LPE509_RS07110	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LPE509_RS07115	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
LPE509_RS07135	COG0151	Belongs to the GarS family
LPE509_RS07140	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
LPE509_RS07180	COG2373	Large extracellular alpha-helical protein
LPE509_RS07185	COG4953	penicillin-binding protein 1C
LPE509_RS07215	COG0531	amino acid
LPE509_RS07240	COG2814	Major facilitator Superfamily
LPE509_RS07245	COG0673	inositol 2-dehydrogenase activity
LPE509_RS07250	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LPE509_RS07270	COG2353	YceI-like domain
LPE509_RS07275	COG3038	cytochrome b561
LPE509_RS07290	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
LPE509_RS07300	COG0823	Involved in the tonB-independent uptake of proteins
LPE509_RS07305	COG2119	membrane
LPE509_RS07315	COG0477	Major facilitator Superfamily
LPE509_RS07335	COG0247	lactate metabolic process
LPE509_RS07335	COG0277	FAD linked oxidase domain protein
LPE509_RS07345	COG0438	transferase activity, transferring glycosyl groups
LPE509_RS07350	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LPE509_RS07375	COG2217	Heavy metal translocating P-type atpase
LPE509_RS07385	COG0429	hydrolase of the alpha beta-hydrolase fold
LPE509_RS07390	COG0585	pseudouridine synthase activity
LPE509_RS07410	COG0768	penicillin binding
LPE509_RS07425	COG0488	(ABC) transporter
LPE509_RS07430	COG1132	(ABC) transporter
LPE509_RS07435	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
LPE509_RS07435	COG0456	acetyltransferase
LPE509_RS07450	COG0789	Transcriptional regulator
LPE509_RS07455	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
LPE509_RS07460	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
LPE509_RS07465	COG0494	nUDIX hydrolase
LPE509_RS07470	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
LPE509_RS07475	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
LPE509_RS07485	COG5654	RES domain protein
LPE509_RS07515	COG0183	Belongs to the thiolase family
LPE509_RS07520	COG1024	Enoyl-CoA hydratase
LPE509_RS07520	COG1250	3-hydroxyacyl-CoA dehydrogenase
LPE509_RS07525	COG1376	ErfK ybiS ycfS ynhG family protein
LPE509_RS07525	COG1388	LysM domain
LPE509_RS07580	COG1183	phosphatidylcholine synthase activity
LPE509_RS07585	COG1012	belongs to the aldehyde dehydrogenase family
LPE509_RS07590	COG1376	ErfK ybiS ycfS ynhG family protein
LPE509_RS07595	COG2902	Dehydrogenase
LPE509_RS07600	COG3038	cytochrome b561
LPE509_RS07625	COG2255	four-way junction helicase activity
LPE509_RS07630	COG0824	Thioesterase
LPE509_RS07650	COG0823	Involved in the tonB-independent uptake of proteins
LPE509_RS07665	COG0352	thiamine-phosphate diphosphorylase activity
LPE509_RS07685	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LPE509_RS07700	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LPE509_RS07705	COG3264	Mechanosensitive ion channel
LPE509_RS07705	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
LPE509_RS07725	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
LPE509_RS07735	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LPE509_RS07740	COG0318	PFAM AMP-dependent synthetase and ligase
LPE509_RS07745	COG0850	regulation of cytokinetic process
LPE509_RS07750	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LPE509_RS07770	COG0105	UTP biosynthetic process
LPE509_RS07775	COG0820	rRNA (adenine-C2-)-methyltransferase activity
LPE509_RS07780	COG3063	Type IV pilus biogenesis stability protein PilW
LPE509_RS07790	COG0124	histidyl-tRNA synthetase
LPE509_RS07805	COG1160	GTP binding
LPE509_RS07810	COG0589	response to stress
LPE509_RS07815	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
LPE509_RS07820	COG0617	tRNA 3'-terminal CCA addition
LPE509_RS07825	COG0861	Integral membrane protein TerC family
LPE509_RS07830	COG1981	membrane
LPE509_RS07840	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
LPE509_RS07850	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LPE509_RS07850	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
LPE509_RS07860	COG0372	Belongs to the citrate synthase family
LPE509_RS07890	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
LPE509_RS07915	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
LPE509_RS07930	COG2274	protein secretion by the type I secretion system
LPE509_RS07935	COG3034	peptidoglycan biosynthetic process
LPE509_RS07945	COG0586	Pfam SNARE associated Golgi protein
LPE509_RS07950	COG0321	lipoyl(octanoyl) transferase activity
LPE509_RS07955	COG2921	Belongs to the UPF0250 family
LPE509_RS07965	COG1686	Belongs to the peptidase S11 family
LPE509_RS07970	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
LPE509_RS07975	COG0475	glutathione-regulated potassium exporter activity
LPE509_RS07975	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LPE509_RS07980	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
LPE509_RS07995	COG0508	dehydrogenase complex catalyzes the overall conversion of
LPE509_RS08000	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LPE509_RS08005	COG0456	acetyltransferase
LPE509_RS08025	COG0308	aminopeptidase N
LPE509_RS08030	COG1196	nuclear chromosome segregation
LPE509_RS08075	COG1522	sequence-specific DNA binding
LPE509_RS08110	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
LPE509_RS08110	COG3264	Mechanosensitive ion channel
LPE509_RS08140	COG0156	8-amino-7-oxononanoate synthase activity
LPE509_RS08150	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
LPE509_RS08160	COG2200	EAL domain
LPE509_RS08185	COG0494	nUDIX hydrolase
LPE509_RS08195	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LPE509_RS08200	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
LPE509_RS08210	COG0436	Aminotransferase
LPE509_RS08220	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LPE509_RS08250	COG1881	PFAM PEBP family protein
LPE509_RS08270	COG1187	pseudouridine synthase activity
LPE509_RS08275	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
LPE509_RS08285	COG0180	Tryptophanyl-tRNA synthetase
LPE509_RS08290	COG0009	L-threonylcarbamoyladenylate synthase
LPE509_RS08295	COG0613	PHP domain protein
LPE509_RS08300	COG1702	phosphate starvation-inducible protein PhoH
LPE509_RS08310	COG4535	Mg2 and Co2 transporter CorC
LPE509_RS08315	COG0745	RESPONSE REGULATOR receiver
LPE509_RS08330	COG0295	cytidine deaminase activity
LPE509_RS08335	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
LPE509_RS08355	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
LPE509_RS08370	COG4221	oxidoreductase activity
LPE509_RS08380	COG0284	orotidine-5'-phosphate decarboxylase activity
LPE509_RS08390	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
LPE509_RS08405	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
LPE509_RS08410	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
LPE509_RS08415	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
LPE509_RS08430	COG0372	Belongs to the citrate synthase family
LPE509_RS08435	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
LPE509_RS08445	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LPE509_RS08475	COG0463	Glycosyl transferase, family 2
LPE509_RS08490	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
LPE509_RS08495	COG0084	hydrolase, TatD family'
LPE509_RS08505	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
LPE509_RS08510	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
LPE509_RS08515	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
LPE509_RS08520	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LPE509_RS08525	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LPE509_RS08535	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
LPE509_RS08540	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LPE509_RS08560	COG0482	sulfurtransferase activity
LPE509_RS08565	COG0316	Belongs to the HesB IscA family
LPE509_RS08585	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LPE509_RS08595	COG0300	oxidoreductase activity
LPE509_RS08605	COG2986	histidine ammonia-lyase
LPE509_RS08610	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
LPE509_RS08625	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
LPE509_RS08630	COG0768	penicillin binding
LPE509_RS08635	COG0772	Belongs to the SEDS family
LPE509_RS08640	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
LPE509_RS08645	COG0673	inositol 2-dehydrogenase activity
LPE509_RS08650	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LPE509_RS08655	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
LPE509_RS08660	COG0326	Molecular chaperone. Has ATPase activity
LPE509_RS08670	COG2515	1-aminocyclopropane-1-carboxylate deaminase
LPE509_RS08675	COG3022	response to hydroperoxide
LPE509_RS08685	COG0174	glutamine synthetase
LPE509_RS08695	COG2165	general secretion pathway protein
LPE509_RS08715	COG3156	type II secretion system protein K
LPE509_RS08740	COG0183	Belongs to the thiolase family
LPE509_RS08745	COG1024	Enoyl-CoA hydratase
LPE509_RS08745	COG1250	3-hydroxyacyl-CoA dehydrogenase
LPE509_RS08750	COG1012	belongs to the aldehyde dehydrogenase family
LPE509_RS08760	COG0815	Transfers the fatty acyl group on membrane lipoproteins
LPE509_RS08765	COG0495	leucyl-tRNA aminoacylation
LPE509_RS08780	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
LPE509_RS08785	COG1286	toxin biosynthetic process
LPE509_RS08795	COG0285	dihydrofolate synthase activity
LPE509_RS08845	COG1496	oxidoreductase activity
LPE509_RS08880	COG4264	IucA IucC family
LPE509_RS08885	COG2814	Major facilitator Superfamily
LPE509_RS08890	COG2814	Major facilitator Superfamily
LPE509_RS08895	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
LPE509_RS08900	COG0673	inositol 2-dehydrogenase activity
LPE509_RS08955	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
LPE509_RS08960	COG0215	cysteine-tRNA ligase activity
LPE509_RS08965	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LPE509_RS08970	COG0159	tryptophan synthase activity
LPE509_RS08975	COG0133	tryptophan synthase activity
LPE509_RS08980	COG0135	phosphoribosylanthranilate isomerase activity
LPE509_RS08990	COG1090	epimerase
LPE509_RS09010	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
LPE509_RS09020	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
LPE509_RS09025	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LPE509_RS09035	COG1388	LysM domain
LPE509_RS09035	COG0741	lytic transglycosylase activity
LPE509_RS09040	COG2917	probably involved in intracellular septation
LPE509_RS09050	COG0642	Histidine kinase
LPE509_RS09065	COG0632	four-way junction helicase activity
LPE509_RS09070	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
LPE509_RS09075	COG0217	transcriptional regulatory protein
LPE509_RS09080	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
LPE509_RS09095	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
LPE509_RS09105	COG0281	malic enzyme
LPE509_RS09120	COG1132	(ABC) transporter
LPE509_RS09135	COG0471	metal ion transport
LPE509_RS09135	COG3273	potassium ion transport
LPE509_RS09175	COG1706	bacterial-type flagellum-dependent cell motility
LPE509_RS09185	COG4786	Flagellar basal body rod
LPE509_RS09190	COG4787	bacterial-type flagellum-dependent cell motility
LPE509_RS09195	COG1749	Flagellar hook protein flgE
LPE509_RS09200	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
LPE509_RS09210	COG1815	bacterial-type flagellum-dependent cell motility
LPE509_RS09235	COG1280	lysine exporter protein (LysE YggA)
LPE509_RS09250	COG1846	Transcriptional regulator
LPE509_RS09255	COG0442	prolyl-tRNA aminoacylation
LPE509_RS09265	COG1278	Cold shock
LPE509_RS09280	COG1294	oxidase, subunit
LPE509_RS09285	COG1271	oxidase subunit
LPE509_RS09295	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
LPE509_RS09305	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LPE509_RS09310	COG0131	Imidazoleglycerol-phosphate dehydratase
LPE509_RS09310	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
LPE509_RS09315	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
LPE509_RS09320	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
LPE509_RS09325	COG0107	imidazoleglycerol-phosphate synthase activity
LPE509_RS09330	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
LPE509_RS09330	COG0140	phosphoribosyl-ATP diphosphatase activity
LPE509_RS09340	COG1472	Belongs to the glycosyl hydrolase 3 family
LPE509_RS09345	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
LPE509_RS09355	COG3158	transport of potassium into the cell
LPE509_RS09360	COG2974	May be involved in recombination
LPE509_RS09375	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
LPE509_RS09400	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LPE509_RS09400	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LPE509_RS09405	COG0307	riboflavin synthase, alpha
LPE509_RS09410	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LPE509_RS09410	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LPE509_RS09415	COG4783	chaperone-mediated protein folding
LPE509_RS09455	COG1355	regulation of microtubule-based process
LPE509_RS09465	COG1666	GTP binding
LPE509_RS09485	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LPE509_RS09510	COG0697	spore germination
LPE509_RS09530	COG3961	Belongs to the TPP enzyme family
LPE509_RS09540	COG1231	oxidoreductase activity
LPE509_RS09575	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
LPE509_RS09600	COG3842	ATPase activity
LPE509_RS09605	COG1176	ABC-type spermidine putrescine transport system, permease component I
LPE509_RS09610	COG1177	transmembrane transport
LPE509_RS09640	COG2070	2-Nitropropane dioxygenase
LPE509_RS09650	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LPE509_RS09670	COG0590	tRNA wobble adenosine to inosine editing
LPE509_RS09685	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LPE509_RS09700	COG1388	LysM domain
LPE509_RS09700	COG0741	lytic transglycosylase activity
LPE509_RS09735	COG3325	Belongs to the glycosyl hydrolase 18 family
LPE509_RS09735	COG3469	chitinase activity
LPE509_RS09740	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
LPE509_RS09745	COG4251	negative regulation of phosphorylation
LPE509_RS09800	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LPE509_RS09800	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LPE509_RS09845	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LPE509_RS09860	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
LPE509_RS09865	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LPE509_RS09895	COG0728	peptidoglycan biosynthetic process
LPE509_RS09905	COG0582	viral genome integration into host DNA
LPE509_RS09910	COG4804	nuclease activity
LPE509_RS09930	COG0232	Belongs to the dGTPase family. Type 2 subfamily
LPE509_RS09970	COG0582	viral genome integration into host DNA
LPE509_RS10020	COG1278	Cold shock
LPE509_RS10025	COG1028	Short-chain dehydrogenase reductase Sdr
LPE509_RS10055	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
LPE509_RS10070	COG0356	it plays a direct role in the translocation of protons across the membrane
LPE509_RS10080	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
LPE509_RS10080	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LPE509_RS10100	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LPE509_RS10145	COG2132	Multicopper oxidase
LPE509_RS10195	COG5001	Diguanylate cyclase
LPE509_RS10195	COG3447	MASE1 domain protein
LPE509_RS10195	COG5002	protein histidine kinase activity
LPE509_RS10200	COG2217	Heavy metal translocating P-type atpase
LPE509_RS10205	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
LPE509_RS10210	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
LPE509_RS10215	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
LPE509_RS10220	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LPE509_RS10275	COG2217	Heavy metal translocating P-type atpase
LPE509_RS10310	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
LPE509_RS10455	COG0629	single-stranded DNA binding
LPE509_RS10485	COG2135	peptidase activity
LPE509_RS10520	COG0833	amino acid
LPE509_RS10550	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
LPE509_RS10565	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LPE509_RS10570	COG0601	transmembrane transport
LPE509_RS10600	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
LPE509_RS10605	COG1022	Amp-dependent synthetase and ligase
LPE509_RS10610	COG1752	Esterase of the alpha-beta hydrolase superfamily
LPE509_RS10615	COG0312	modulator of DNA gyrase
LPE509_RS10625	COG0670	Belongs to the BI1 family
LPE509_RS10630	COG1013	pyruvate-flavodoxin oxidoreductase activity
LPE509_RS10635	COG0674	pyruvate-flavodoxin oxidoreductase activity
LPE509_RS10635	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
LPE509_RS10655	COG1381	Involved in DNA repair and RecF pathway recombination
LPE509_RS10660	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
LPE509_RS10675	COG0800	Aldolase
LPE509_RS10685	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
LPE509_RS10690	COG0196	riboflavin kinase activity
LPE509_RS10695	COG0589	response to stress
LPE509_RS10705	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
LPE509_RS10750	COG0686	Belongs to the AlaDH PNT family
LPE509_RS10775	COG1994	Peptidase M50
LPE509_RS10825	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
LPE509_RS10850	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LPE509_RS10880	COG1194	a g-specific adenine glycosylase
LPE509_RS10925	COG0626	cystathionine gamma-synthase activity
LPE509_RS10930	COG0204	Acyl-transferase
LPE509_RS10950	COG1472	Belongs to the glycosyl hydrolase 3 family
LPE509_RS10975	COG3706	GGDEF domain
LPE509_RS10985	COG2340	Cysteine-rich secretory protein family
LPE509_RS11020	COG1024	Enoyl-CoA hydratase
LPE509_RS11025	COG1024	Enoyl-CoA hydratase
LPE509_RS11030	COG1960	acyl-CoA dehydrogenase activity
LPE509_RS11035	COG0514	ATP-dependent DNA helicase (RecQ)
LPE509_RS11050	COG3360	Dodecin
LPE509_RS11070	COG1138	Cytochrome C-type biogenesis protein
LPE509_RS11100	COG0616	signal peptide processing
LPE509_RS11120	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LPE509_RS11125	COG0577	efflux transmembrane transporter activity
LPE509_RS11130	COG1136	(ABC) transporter
LPE509_RS11145	COG5007	Belongs to the BolA IbaG family
LPE509_RS11160	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
LPE509_RS11165	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LPE509_RS11170	COG1127	ABC transporter
LPE509_RS11180	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
LPE509_RS11195	COG1137	ATPase activity
LPE509_RS11200	COG0512	Glutamine amidotransferase of anthranilate synthase
LPE509_RS11250	COG0739	heme binding
LPE509_RS11255	COG0705	Rhomboid family
LPE509_RS11285	COG0542	response to heat
LPE509_RS11305	COG1187	pseudouridine synthase activity
LPE509_RS11310	COG1792	Involved in formation and maintenance of cell shape
LPE509_RS11315	COG1077	Cell shape determining protein MreB Mrl
LPE509_RS11320	COG1555	photosystem II stabilization
LPE509_RS11325	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LPE509_RS11340	COG0475	glutathione-regulated potassium exporter activity
LPE509_RS11345	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LPE509_RS11345	COG0574	Belongs to the PEP-utilizing enzyme family
LPE509_RS11355	COG1960	acyl-CoA dehydrogenase activity
LPE509_RS11360	COG0659	secondary active sulfate transmembrane transporter activity
LPE509_RS11365	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
LPE509_RS11370	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
LPE509_RS11375	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
LPE509_RS11390	COG2223	nitrite transmembrane transporter activity
LPE509_RS11395	COG0545	Peptidyl-prolyl cis-trans isomerase
LPE509_RS11400	COG1760	l-serine dehydratase
LPE509_RS11405	COG1696	Membrane protein involved in D-alanine export
LPE509_RS11420	COG0037	tRNA processing
LPE509_RS11430	COG2091	lysine biosynthetic process via aminoadipic acid
LPE509_RS11435	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
LPE509_RS11435	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
LPE509_RS11490	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LPE509_RS11520	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LPE509_RS11540	COG1088	dTDP-glucose 4,6-dehydratase activity
LPE509_RS11555	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
LPE509_RS11565	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
LPE509_RS11570	COG2089	acid synthase
LPE509_RS11575	COG1083	cytidylyl-transferase
LPE509_RS11585	COG0107	imidazoleglycerol-phosphate synthase activity
LPE509_RS11600	COG3104	oligopeptide transport
LPE509_RS11605	COG2827	Endonuclease containing a URI domain
LPE509_RS11645	COG0305	Participates in initiation and elongation during chromosome replication
LPE509_RS11655	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
LPE509_RS11680	COG0628	permease
LPE509_RS11685	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
LPE509_RS11690	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
LPE509_RS11725	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LPE509_RS11730	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LPE509_RS11740	COG1823	symporter activity
LPE509_RS11755	COG0745	RESPONSE REGULATOR receiver
LPE509_RS11760	COG5002	protein histidine kinase activity
LPE509_RS11765	COG1297	OPT oligopeptide transporter protein
LPE509_RS11785	COG0010	Belongs to the arginase family
LPE509_RS11815	COG0488	(ABC) transporter
LPE509_RS11825	COG0156	8-amino-7-oxononanoate synthase activity
LPE509_RS11830	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
LPE509_RS11835	COG1538	Outer membrane efflux protein
LPE509_RS11845	COG0659	secondary active sulfate transmembrane transporter activity
LPE509_RS11850	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
LPE509_RS11855	COG3177	Filamentation induced by cAMP protein fic
LPE509_RS11855	COG0666	response to abiotic stimulus
LPE509_RS11875	COG0187	DNA topoisomerase II activity
LPE509_RS11885	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
LPE509_RS11890	COG0783	Belongs to the Dps family
LPE509_RS11905	COG4232	protein-disulfide reductase activity
LPE509_RS11920	COG1131	(ABC) transporter
LPE509_RS11950	COG3220	belongs to the UPF0276 family
LPE509_RS11970	COG4689	acetoacetate decarboxylase
LPE509_RS11990	COG3220	belongs to the UPF0276 family
LPE509_RS12005	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
LPE509_RS12010	COG0741	lytic transglycosylase activity
LPE509_RS12020	COG0842	Transport permease protein
LPE509_RS12025	COG0842	Transport permease protein
LPE509_RS12030	COG1131	(ABC) transporter
LPE509_RS12035	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LPE509_RS12050	COG0814	amino acid
LPE509_RS12055	COG0814	amino acid
LPE509_RS12060	COG0338	D12 class N6 adenine-specific DNA methyltransferase
LPE509_RS12075	COG0281	malic enzyme
LPE509_RS12085	COG0708	Exodeoxyribonuclease III
LPE509_RS12090	COG0708	Exodeoxyribonuclease III
LPE509_RS12095	COG2852	Protein conserved in bacteria
LPE509_RS12245	COG0519	Catalyzes the synthesis of GMP from XMP
LPE509_RS12290	COG1064	alcohol dehydrogenase
LPE509_RS12295	COG1253	flavin adenine dinucleotide binding
LPE509_RS12305	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LPE509_RS12310	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
LPE509_RS12315	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
LPE509_RS12320	COG2151	metal-sulfur cluster biosynthetic enzyme
LPE509_RS12325	COG0822	iron-sulfur transferase activity
LPE509_RS12330	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
LPE509_RS12335	COG0719	Fe-S assembly protein
LPE509_RS12340	COG0396	ATPase activity
LPE509_RS12345	COG0719	Fe-S assembly protein
LPE509_RS12350	COG1959	2 iron, 2 sulfur cluster binding
LPE509_RS12355	COG3243	poly(R)-hydroxyalkanoic acid synthase
LPE509_RS12390	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
LPE509_RS12395	COG0347	Belongs to the P(II) protein family
LPE509_RS12405	COG0606	chelatase, subunit chli
LPE509_RS12415	COG0540	Belongs to the ATCase OTCase family
LPE509_RS12420	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
LPE509_RS12435	COG1392	Phosphate transport regulator
LPE509_RS12440	COG0306	phosphate transporter
LPE509_RS12455	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
LPE509_RS12460	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LPE509_RS12465	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
LPE509_RS12490	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
LPE509_RS12495	COG0739	heme binding
LPE509_RS12500	COG0700	Nucleoside recognition
LPE509_RS12505	COG2715	membrane protein required for spore maturation
LPE509_RS12525	COG1028	Short-chain dehydrogenase reductase Sdr
LPE509_RS12530	COG1028	Short-chain dehydrogenase reductase Sdr
LPE509_RS12550	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LPE509_RS12565	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LPE509_RS12600	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
LPE509_RS12610	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
LPE509_RS12615	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
LPE509_RS12625	COG2814	Major facilitator Superfamily
LPE509_RS12645	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
LPE509_RS12655	COG0508	dehydrogenase complex catalyzes the overall conversion of
LPE509_RS12665	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
LPE509_RS12670	COG1053	succinate dehydrogenase
LPE509_RS12675	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
LPE509_RS12680	COG2009	succinate dehydrogenase
LPE509_RS12715	COG0572	uridine kinase
LPE509_RS12740	COG0656	L-ascorbic acid biosynthetic process
LPE509_RS12765	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
LPE509_RS12770	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
LPE509_RS12775	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LPE509_RS12780	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LPE509_RS12785	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LPE509_RS12805	COG0575	Belongs to the CDS family
LPE509_RS12810	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
LPE509_RS12825	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
LPE509_RS12830	COG4942	peptidase
LPE509_RS12835	COG0793	Belongs to the peptidase S41A family
LPE509_RS12850	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
LPE509_RS12855	COG0165	Argininosuccinate lyase
LPE509_RS12860	COG0137	argininosuccinate synthase activity
LPE509_RS12865	COG1126	abc transporter atp-binding protein
LPE509_RS12870	COG0765	amino acid transport
LPE509_RS12875	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LPE509_RS12880	COG1438	arginine binding
LPE509_RS12900	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
LPE509_RS12905	COG0330	HflC and HflK could
LPE509_RS12910	COG0330	HflC and HflK could
LPE509_RS12920	COG1363	Peptidase, m42
LPE509_RS12925	COG0220	tRNA (guanine-N7-)-methyltransferase activity
LPE509_RS12940	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
LPE509_RS12945	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
LPE509_RS12955	COG1183	phosphatidylcholine synthase activity
LPE509_RS12975	COG3588	fructose-bisphosphate aldolase
LPE509_RS12980	COG3568	Endonuclease Exonuclease Phosphatase
LPE509_RS12990	COG3227	Zinc metalloprotease (Elastase)
LPE509_RS12995	COG0511	ligase activity, forming carbon-carbon bonds
LPE509_RS12995	COG5016	pyruvate
LPE509_RS13005	COG0511	ligase activity, forming carbon-carbon bonds
LPE509_RS13010	COG0439	Biotin carboxylase
LPE509_RS13015	COG2264	protein methyltransferase activity
LPE509_RS13020	COG0138	bifunctional purine biosynthesis protein purh
LPE509_RS13035	COG0477	Major facilitator Superfamily
LPE509_RS13150	COG1733	regulation of RNA biosynthetic process
LPE509_RS13165	COG1566	PFAM secretion protein HlyD family protein
LPE509_RS13185	COG1278	Cold shock
LPE509_RS13190	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
LPE509_RS13200	COG3655	Transcriptional regulator
LPE509_RS13210	COG2814	Major facilitator Superfamily
LPE509_RS13215	COG0800	Aldolase
LPE509_RS13220	COG0837	glucose binding
LPE509_RS13225	COG0129	dihydroxy-acid dehydratase activity
LPE509_RS13230	COG0363	glucosamine-6-phosphate deaminase activity
LPE509_RS13235	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
LPE509_RS13250	COG1999	signal sequence binding
LPE509_RS13260	COG1612	heme a metabolic process
LPE509_RS13300	COG0531	amino acid
LPE509_RS13320	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
LPE509_RS13330	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
LPE509_RS13335	COG0336	Belongs to the RNA methyltransferase TrmD family
LPE509_RS13345	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LPE509_RS13375	COG1131	(ABC) transporter
LPE509_RS13380	COG0842	Transport permease protein
LPE509_RS13390	COG1704	LemA family
LPE509_RS13425	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
LPE509_RS13450	COG3706	GGDEF domain
LPE509_RS13455	COG0735	belongs to the Fur family
LPE509_RS13460	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LPE509_RS13465	COG2914	Belongs to the UPF0125 (RnfH) family
LPE509_RS13470	COG2867	negative regulation of translational initiation
LPE509_RS13485	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
LPE509_RS13500	COG1560	Kdo2-lipid A biosynthetic process
LPE509_RS13510	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LPE509_RS13525	COG1028	Short-chain dehydrogenase reductase Sdr
LPE509_RS13530	COG2814	Major facilitator Superfamily
LPE509_RS13535	COG0629	single-stranded DNA binding
LPE509_RS13680	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
LPE509_RS13695	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
LPE509_RS13700	COG0085	RNA polymerase activity
LPE509_RS13730	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
LPE509_RS13800	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LPE509_RS13805	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
LPE509_RS13815	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
LPE509_RS13850	COG1509	lysine 2,3-aminomutase activity
LPE509_RS13855	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
LPE509_RS13865	COG4221	oxidoreductase activity
LPE509_RS13885	COG2226	methyltransferase
LPE509_RS13895	COG0583	DNA-binding transcription factor activity
LPE509_RS13905	COG5002	protein histidine kinase activity
LPE509_RS13905	COG0784	Response regulator, receiver
LPE509_RS13905	COG2198	Histidine kinase
LPE509_RS13925	COG0583	DNA-binding transcription factor activity
LPE509_RS13930	COG2814	Major facilitator Superfamily
LPE509_RS13940	COG1335	isochorismatase
LPE509_RS13945	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
LPE509_RS13950	COG0433	COG0433 Predicted ATPase
LPE509_RS13960	COG0598	Magnesium transport protein CorA
LPE509_RS13985	COG1573	uracil-dna glycosylase
LPE509_RS14010	COG1566	PFAM secretion protein HlyD family protein
LPE509_RS14035	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
LPE509_RS14045	COG0513	Belongs to the DEAD box helicase family
LPE509_RS14055	COG1393	Belongs to the ArsC family
LPE509_RS14085	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LPE509_RS14090	COG2066	Belongs to the glutaminase family
LPE509_RS14105	COG1012	belongs to the aldehyde dehydrogenase family
LPE509_RS14125	COG1196	nuclear chromosome segregation
LPE509_RS14135	COG0735	belongs to the Fur family
LPE509_RS14140	COG2217	Heavy metal translocating P-type atpase
LPE509_RS14145	COG3706	GGDEF domain
LPE509_RS14155	COG0531	amino acid
LPE509_RS14175	COG2274	protein secretion by the type I secretion system
LPE509_RS14180	COG0583	DNA-binding transcription factor activity
LPE509_RS14185	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
LPE509_RS14190	COG3002	Belongs to the UPF0753 family
LPE509_RS14215	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
LPE509_RS14220	COG0583	DNA-binding transcription factor activity
LPE509_RS14225	COG1380	Effector of murein hydrolase LrgA
LPE509_RS14230	COG1346	cytolysis
LPE509_RS14235	COG0415	Belongs to the DNA photolyase family
LPE509_RS14265	COG3046	protein related to deoxyribodipyrimidine photolyase
LPE509_RS14270	COG1028	Short-chain dehydrogenase reductase Sdr
LPE509_RS14275	COG1307	EDD domain protein, DegV family
LPE509_RS14290	COG1294	oxidase, subunit
LPE509_RS14295	COG1271	oxidase subunit
LPE509_RS14350	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LPE509_RS14360	COG1172	Belongs to the binding-protein-dependent transport system permease family
LPE509_RS14390	COG0501	Belongs to the peptidase M48B family
LPE509_RS14395	COG2226	methyltransferase
LPE509_RS14405	COG2814	Major facilitator Superfamily
LPE509_RS14410	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LPE509_RS14425	COG0583	DNA-binding transcription factor activity
LPE509_RS14455	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
LPE509_RS14460	COG2354	Protein conserved in bacteria
LPE509_RS14500	COG0024	Methionine aminopeptidase
LPE509_RS14505	COG2200	EAL domain
LPE509_RS14510	COG5001	Diguanylate cyclase
LPE509_RS14565	COG2963	transposase activity
LPE509_RS14570	COG2801	Transposase and inactivated derivatives
LPE509_RS14590	COG0339	signal peptide processing
LPE509_RS14600	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
LPE509_RS14605	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
LPE509_RS14610	COG0126	phosphoglycerate kinase activity
LPE509_RS14615	COG0469	pyruvate kinase activity
LPE509_RS14640	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
LPE509_RS14660	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LPE509_RS14680	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LPE509_RS14685	COG1116	anion transmembrane transporter activity
LPE509_RS14705	COG0404	The glycine cleavage system catalyzes the degradation of glycine
LPE509_RS14715	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LPE509_RS14725	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LPE509_RS14730	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
LPE509_RS14760	COG2252	PERMEase
LPE509_RS14770	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LPE509_RS14780	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LPE509_RS14805	COG2824	Alkylphosphonate utilization operon protein PhnA
LPE509_RS14820	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
LPE509_RS14825	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LPE509_RS14830	COG0557	exoribonuclease II activity
LPE509_RS14845	COG1671	Belongs to the UPF0178 family
LPE509_RS14865	COG4067	protein conserved in archaea
LPE509_RS14865	COG0189	ligase activity
LPE509_RS14895	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LPE509_RS14900	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LPE509_RS14905	COG0006	proline dipeptidase activity
LPE509_RS14910	COG3079	Belongs to the UPF0149 family
LPE509_RS14915	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
LPE509_RS14920	COG0069	glutamate synthase activity
LPE509_RS14925	COG4251	negative regulation of phosphorylation
LPE509_RS14925	COG2203	Gaf domain
LPE509_RS14925	COG3706	GGDEF domain
LPE509_RS14925	COG5001	Diguanylate cyclase
LPE509_RS14930	COG0556	nucleotide-excision repair
LPE509_RS14935	COG0436	Aminotransferase
LPE509_RS15005	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
LPE509_RS15025	COG0583	DNA-binding transcription factor activity
LPE509_RS15045	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
LPE509_RS15100	COG3781	membrane
LPE509_RS15155	COG2234	aminopeptidase activity
LPE509_RS15165	COG5001	Diguanylate cyclase
LPE509_RS15165	COG3300	MHYT domain
LPE509_RS15175	COG0306	phosphate transporter
LPE509_RS15180	COG0531	amino acid
LPE509_RS15205	COG3028	Belongs to the UPF0307 family
LPE509_RS15215	COG3227	Zinc metalloprotease (Elastase)
LPE509_RS15235	COG1566	PFAM secretion protein HlyD family protein
LPE509_RS15245	COG1741	Belongs to the pirin family
LPE509_RS15255	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LPE509_RS15260	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
LPE509_RS15280	COG1166	arginine decarboxylase activity
LPE509_RS15290	COG0187	DNA topoisomerase II activity
LPE509_RS15300	COG0592	DNA-directed DNA polymerase activity
LPE509_RS15540	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LPE509_RS15655	COG1132	(ABC) transporter