locus-tag	class	description
GH742_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GH742_RS00035	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GH742_RS00040	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GH742_RS00050	COG1741	Belongs to the pirin family
GH742_RS00055	COG0655	NAD(P)H dehydrogenase (quinone) activity
GH742_RS00065	COG3240	lipase activity
GH742_RS00095	COG0583	DNA-binding transcription factor activity
GH742_RS00100	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GH742_RS00120	COG2818	Glycosylase
GH742_RS00135	COG0531	amino acid
GH742_RS00145	COG0306	phosphate transporter
GH742_RS00205	COG0436	Aminotransferase
GH742_RS00210	COG0556	nucleotide-excision repair
GH742_RS00230	COG3079	Belongs to the UPF0149 family
GH742_RS00235	COG0006	proline dipeptidase activity
GH742_RS00240	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GH742_RS00245	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GH742_RS00265	COG0577	efflux transmembrane transporter activity
GH742_RS00265	COG1136	(ABC) transporter
GH742_RS00290	COG1294	oxidase, subunit
GH742_RS00305	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GH742_RS00315	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GH742_RS00335	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
GH742_RS00340	COG1461	Dihydroxyacetone kinase
GH742_RS00355	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
GH742_RS00360	COG4181	ATPase activity
GH742_RS00385	COG2199	diguanylate cyclase activity
GH742_RS00390	COG1475	DNA binding
GH742_RS00405	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GH742_RS00420	COG3706	GGDEF domain
GH742_RS00425	COG2814	Major facilitator Superfamily
GH742_RS00460	COG0583	DNA-binding transcription factor activity
GH742_RS00470	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GH742_RS00470	COG2010	Cytochrome c
GH742_RS00475	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GH742_RS00480	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GH742_RS00490	COG1845	cytochrome c oxidase, subunit III
GH742_RS00500	COG2200	EAL domain
GH742_RS00505	COG1475	DNA binding
GH742_RS00510	COG1192	Involved in chromosome partitioning
GH742_RS00515	COG0357	Ribosomal RNA small subunit methyltransferase G
GH742_RS00530	COG0662	Cupin 2, conserved barrel domain protein
GH742_RS00530	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
GH742_RS00550	COG2878	Part of a membrane complex involved in electron transport
GH742_RS00555	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GH742_RS00565	COG0598	Magnesium transport protein CorA
GH742_RS00590	COG0252	asparaginase activity
GH742_RS00605	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
GH742_RS00610	COG0730	response to heat
GH742_RS00620	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
GH742_RS00640	COG0814	amino acid
GH742_RS00655	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GH742_RS00665	COG0398	Pfam SNARE associated Golgi protein
GH742_RS00670	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GH742_RS00670	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GH742_RS00675	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GH742_RS00675	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GH742_RS00690	COG0477	Major facilitator Superfamily
GH742_RS00695	COG0415	Belongs to the DNA photolyase family
GH742_RS00700	COG2252	PERMEase
GH742_RS00715	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
GH742_RS00730	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GH742_RS00775	COG3469	chitinase activity
GH742_RS00775	COG3325	Belongs to the glycosyl hydrolase 18 family
GH742_RS00790	COG1116	anion transmembrane transporter activity
GH742_RS00800	COG1475	DNA binding
GH742_RS00805	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GH742_RS00820	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GH742_RS00855	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
GH742_RS00870	COG0469	pyruvate kinase activity
GH742_RS00880	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GH742_RS00885	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GH742_RS00895	COG0339	signal peptide processing
GH742_RS00905	COG0582	viral genome integration into host DNA
GH742_RS00965	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GH742_RS00970	COG3328	transposase activity
GH742_RS00985	COG1525	nuclease
GH742_RS01000	COG1484	DNA-dependent DNA replication
GH742_RS01020	COG0590	tRNA wobble adenosine to inosine editing
GH742_RS01030	COG3328	transposase activity
GH742_RS01065	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GH742_RS01105	COG0513	Belongs to the DEAD box helicase family
GH742_RS01115	COG0424	maF-like protein
GH742_RS01135	COG1393	Belongs to the ArsC family
GH742_RS01205	COG0598	Magnesium transport protein CorA
GH742_RS01255	COG0714	Associated with various cellular activities
GH742_RS01270	COG2304	oxidoreductase activity
GH742_RS01295	COG1278	Cold shock
GH742_RS01300	COG2081	HI0933 family
GH742_RS01330	COG0517	IMP dehydrogenase activity
GH742_RS01330	COG0516	GMP reductase activity
GH742_RS01330	COG0517	IMP dehydrogenase activity
GH742_RS01330	COG0516	GMP reductase activity
GH742_RS01335	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
GH742_RS01340	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GH742_RS01365	COG2183	response to ionizing radiation
GH742_RS01385	COG0484	heat shock protein binding
GH742_RS01390	COG0497	DNA recombination
GH742_RS01400	COG1217	gtp-binding protein TYPA
GH742_RS01420	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GH742_RS01430	COG1396	sequence-specific DNA binding
GH742_RS01435	COG3135	benzoate transporter
GH742_RS01460	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
GH742_RS01465	COG0210	DNA helicase
GH742_RS01480	COG2719	SpoVR family
GH742_RS01490	COG2766	serine protein kinase
GH742_RS01495	COG0308	aminopeptidase N
GH742_RS01530	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GH742_RS01540	COG2814	Major facilitator Superfamily
GH742_RS01545	COG2814	Major facilitator Superfamily
GH742_RS01565	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GH742_RS01570	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GH742_RS01625	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
GH742_RS01630	COG1034	ATP synthesis coupled electron transport
GH742_RS01635	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
GH742_RS01680	COG0195	Participates in both transcription termination and antitermination
GH742_RS01715	COG0302	gtp cyclohydrolase
GH742_RS01720	COG0537	adenosine 5'-monophosphoramidase activity
GH742_RS01725	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
GH742_RS01740	COG0531	amino acid
GH742_RS01755	COG0277	FAD linked oxidase domain protein
GH742_RS01765	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
GH742_RS01790	COG0439	Biotin carboxylase
GH742_RS01795	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GH742_RS01805	COG2945	thiolester hydrolase activity
GH742_RS01810	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
GH742_RS01840	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
GH742_RS01845	COG2009	succinate dehydrogenase
GH742_RS01850	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
GH742_RS01860	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GH742_RS01895	COG2271	Major facilitator Superfamily
GH742_RS01910	COG0789	Transcriptional regulator
GH742_RS01945	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
GH742_RS01950	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GH742_RS01960	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
GH742_RS02000	COG1028	Short-chain dehydrogenase reductase Sdr
GH742_RS02005	COG1028	Short-chain dehydrogenase reductase Sdr
GH742_RS02010	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
GH742_RS02025	COG0163	prenyltransferase activity
GH742_RS02055	COG1196	nuclear chromosome segregation
GH742_RS02065	COG1872	DUF167
GH742_RS02070	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GH742_RS02085	COG0772	Belongs to the SEDS family
GH742_RS02115	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GH742_RS02140	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
GH742_RS02170	COG0758	DNA mediated transformation
GH742_RS02185	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GH742_RS02205	COG2027	D-alanyl-D-alanine carboxypeptidase
GH742_RS02225	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
GH742_RS02235	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
GH742_RS02265	COG1960	acyl-CoA dehydrogenase activity
GH742_RS02275	COG5001	Diguanylate cyclase
GH742_RS02275	COG3300	MHYT domain
GH742_RS02330	COG1484	DNA-dependent DNA replication
GH742_RS02415	COG0408	coproporphyrinogen oxidase activity
GH742_RS02440	COG4591	ABC-type transport system involved in lipoprotein release permease component
GH742_RS02450	COG1981	membrane
GH742_RS02460	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GH742_RS02465	COG0113	porphobilinogen synthase activity
GH742_RS02470	COG0113	porphobilinogen synthase activity
GH742_RS02475	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GH742_RS02495	COG1472	Belongs to the glycosyl hydrolase 3 family
GH742_RS02505	COG3071	HemY protein
GH742_RS02515	COG2205	protein histidine kinase activity
GH742_RS02515	COG0784	Response regulator, receiver
GH742_RS02535	COG0343	queuine tRNA-ribosyltransferase activity
GH742_RS02540	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GH742_RS02545	COG2860	membrane
GH742_RS02610	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GH742_RS02610	COG0072	phenylalanine-tRNA ligase activity
GH742_RS02615	COG0776	regulation of translation
GH742_RS02630	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GH742_RS02635	COG0723	plastoquinol--plastocyanin reductase activity
GH742_RS02640	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GH742_RS02645	COG2857	Cytochrome c1
GH742_RS02650	COG0625	glutathione transferase activity
GH742_RS02655	COG2969	positive regulation of protein catabolic process
GH742_RS02660	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
GH742_RS02660	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GH742_RS02665	COG0802	atpase or kinase
GH742_RS02670	COG0860	N-Acetylmuramoyl-L-alanine amidase
GH742_RS02675	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GH742_RS02690	COG0859	PFAM glycosyl transferase family 9
GH742_RS02730	COG0742	ribosomal rna small subunit methyltransferase
GH742_RS02735	COG0612	Peptidase, M16
GH742_RS02740	COG0612	Peptidase, M16
GH742_RS02745	COG0552	protein localization to endoplasmic reticulum
GH742_RS02750	COG2884	Cell division ATP-binding protein ftsE
GH742_RS02755	COG2177	Part of the ABC transporter FtsEX involved in
GH742_RS02775	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GH742_RS02785	COG0306	phosphate transporter
GH742_RS02790	COG1392	Phosphate transport regulator
GH742_RS02845	COG0602	queuosine metabolic process
GH742_RS02850	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
GH742_RS02855	COG2885	chlorophyll binding
GH742_RS02860	COG3218	ABC-type transport auxiliary lipoprotein component
GH742_RS02870	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GH742_RS02875	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GH742_RS02920	COG0582	viral genome integration into host DNA
GH742_RS02980	COG5265	(ABC) transporter
GH742_RS02985	COG5265	(ABC) transporter
GH742_RS02990	COG0656	L-ascorbic acid biosynthetic process
GH742_RS03015	COG3344	reverse transcriptase
GH742_RS03100	COG4584	PFAM Integrase catalytic
GH742_RS03180	COG3328	transposase activity
GH742_RS03185	COG3505	Type IV secretory pathway VirD4
GH742_RS03195	COG2948	multi-organism process
GH742_RS03305	COG4584	PFAM Integrase catalytic
GH742_RS03355	COG4584	PFAM Integrase catalytic
GH742_RS03390	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GH742_RS03390	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GH742_RS03410	COG3220	belongs to the UPF0276 family
GH742_RS03435	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GH742_RS03445	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GH742_RS03445	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GH742_RS03450	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GH742_RS03450	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GH742_RS03475	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
GH742_RS03530	COG4584	PFAM Integrase catalytic
GH742_RS03550	COG2824	Alkylphosphonate utilization operon protein PhnA
GH742_RS03555	COG3325	Belongs to the glycosyl hydrolase 18 family
GH742_RS03555	COG3469	chitinase activity
GH742_RS03580	COG2205	protein histidine kinase activity
GH742_RS03590	COG2814	Major facilitator Superfamily
GH742_RS03640	COG0745	RESPONSE REGULATOR receiver
GH742_RS03645	COG5002	protein histidine kinase activity
GH742_RS03660	COG3706	GGDEF domain
GH742_RS03670	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GH742_RS03685	COG2201	protein-glutamate methylesterase activity
GH742_RS03720	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GH742_RS03725	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GH742_RS03790	COG0583	DNA-binding transcription factor activity
GH742_RS03805	COG2814	Major facilitator Superfamily
GH742_RS03840	COG3227	Zinc metalloprotease (Elastase)
GH742_RS03935	COG0596	Alpha beta hydrolase
GH742_RS03940	COG2827	Endonuclease containing a URI domain
GH742_RS03965	COG0714	Associated with various cellular activities
GH742_RS03975	COG0281	malic enzyme
GH742_RS03980	COG3706	GGDEF domain
GH742_RS03980	COG4251	negative regulation of phosphorylation
GH742_RS03980	COG5001	Diguanylate cyclase
GH742_RS03980	COG2203	Gaf domain
GH742_RS03995	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GH742_RS04000	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GH742_RS04005	COG0047	phosphoribosylformylglycinamidine synthase activity
GH742_RS04020	COG0151	Belongs to the GarS family
GH742_RS04025	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GH742_RS04065	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GH742_RS04070	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GH742_RS04085	COG1271	oxidase subunit
GH742_RS04090	COG1294	oxidase, subunit
GH742_RS04100	COG1028	Short-chain dehydrogenase reductase Sdr
GH742_RS04105	COG3046	protein related to deoxyribodipyrimidine photolyase
GH742_RS04110	COG0625	glutathione transferase activity
GH742_RS04135	COG1612	heme a metabolic process
GH742_RS04160	COG0330	HflC and HflK could
GH742_RS04175	COG1278	Cold shock
GH742_RS04205	COG2149	membrane
GH742_RS04210	COG0606	chelatase, subunit chli
GH742_RS04220	COG0347	Belongs to the P(II) protein family
GH742_RS04230	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GH742_RS04270	COG0398	Pfam SNARE associated Golgi protein
GH742_RS04390	COG0450	alkyl hydroperoxide reductase
GH742_RS04415	COG2340	Cysteine-rich secretory protein family
GH742_RS04420	COG2032	superoxide dismutase activity
GH742_RS04430	COG1902	pentaerythritol trinitrate reductase activity
GH742_RS04430	COG0446	pyridine nucleotide-disulphide oxidoreductase
GH742_RS04435	COG1597	lipid kinase activity
GH742_RS04440	COG0513	Belongs to the DEAD box helicase family
GH742_RS04460	COG3240	lipase activity
GH742_RS04470	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
GH742_RS04475	COG1519	Transferase
GH742_RS04480	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GH742_RS04485	COG2890	protein-(glutamine-N5) methyltransferase activity
GH742_RS04510	COG1040	competence protein
GH742_RS04515	COG2226	methyltransferase
GH742_RS04530	COG2197	response regulator
GH742_RS04565	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GH742_RS04565	COG2169	Transcriptional regulator
GH742_RS04590	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GH742_RS04610	COG0795	lipopolysaccharide-transporting ATPase activity
GH742_RS04615	COG0795	lipopolysaccharide-transporting ATPase activity
GH742_RS04650	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GH742_RS04665	COG1959	2 iron, 2 sulfur cluster binding
GH742_RS04670	COG0719	Fe-S assembly protein
GH742_RS04675	COG0396	ATPase activity
GH742_RS04680	COG0719	Fe-S assembly protein
GH742_RS04685	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GH742_RS04695	COG2151	metal-sulfur cluster biosynthetic enzyme
GH742_RS04700	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
GH742_RS04755	COG4689	acetoacetate decarboxylase
GH742_RS04765	COG1028	Short-chain dehydrogenase reductase Sdr
GH742_RS04790	COG0435	Glutathione S-transferase
GH742_RS04795	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
GH742_RS04800	COG1199	ATP-dependent helicase activity
GH742_RS04805	COG1214	PFAM Peptidase M22, glycoprotease
GH742_RS04815	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
GH742_RS04825	COG0531	amino acid
GH742_RS04840	COG0271	Belongs to the BolA IbaG family
GH742_RS04845	COG4969	Belongs to the N-Me-Phe pilin family
GH742_RS04850	COG4969	Belongs to the N-Me-Phe pilin family
GH742_RS04855	COG4969	Belongs to the N-Me-Phe pilin family
GH742_RS04860	COG0205	6-phosphofructokinase activity
GH742_RS04920	COG4232	protein-disulfide reductase activity
GH742_RS04955	COG1028	Short-chain dehydrogenase reductase Sdr
GH742_RS04990	COG1987	bacterial-type flagellum assembly
GH742_RS05000	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GH742_RS05025	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GH742_RS05055	COG0662	Cupin 2, conserved barrel domain protein
GH742_RS05055	COG2207	Transcriptional regulator
GH742_RS05075	COG3012	SEC-C Motif Domain Protein
GH742_RS05090	COG0723	plastoquinol--plastocyanin reductase activity
GH742_RS05090	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GH742_RS05105	COG0702	epimerase
GH742_RS05135	COG0232	Belongs to the dGTPase family. Type 2 subfamily
GH742_RS05160	COG2951	lytic endotransglycosylase activity
GH742_RS05170	COG0681	Belongs to the peptidase S26 family
GH742_RS05180	COG0571	ribonuclease III activity
GH742_RS05185	COG0488	(ABC) transporter
GH742_RS05190	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GH742_RS05200	COG1862	Preprotein translocase
GH742_RS05205	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GH742_RS05210	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GH742_RS05290	COG2337	Toxic component of a toxin-antitoxin (TA) module
GH742_RS05315	COG2313	pseudouridylate synthase activity
GH742_RS05350	COG4591	ABC-type transport system involved in lipoprotein release permease component
GH742_RS05380	COG0625	glutathione transferase activity
GH742_RS05410	COG0584	glycerophosphoryl diester phosphodiesterase
GH742_RS05415	COG1653	transport
GH742_RS05425	COG0657	acetylesterase activity
GH742_RS05435	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
GH742_RS05445	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GH742_RS05480	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GH742_RS05510	COG0517	IMP dehydrogenase activity
GH742_RS05510	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
GH742_RS05570	COG3104	oligopeptide transport
GH742_RS05605	COG1134	teichoic acid transport
GH742_RS05660	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GH742_RS05675	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GH742_RS05690	COG2091	lysine biosynthetic process via aminoadipic acid
GH742_RS05700	COG0037	tRNA processing
GH742_RS05705	COG2271	Major facilitator Superfamily
GH742_RS05710	COG1760	l-serine dehydratase
GH742_RS05720	COG2223	nitrite transmembrane transporter activity
GH742_RS05750	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
GH742_RS05755	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
GH742_RS05785	COG0475	glutathione-regulated potassium exporter activity
GH742_RS05800	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GH742_RS05805	COG1555	photosystem II stabilization
GH742_RS05810	COG2827	Endonuclease containing a URI domain
GH742_RS05820	COG1077	Cell shape determining protein MreB Mrl
GH742_RS05825	COG1792	Involved in formation and maintenance of cell shape
GH742_RS05835	COG3177	Filamentation induced by cAMP protein fic
GH742_RS05835	COG0666	response to abiotic stimulus
GH742_RS05840	COG1187	pseudouridine synthase activity
GH742_RS05855	COG0542	response to heat
GH742_RS05870	COG1177	transmembrane transport
GH742_RS05875	COG1176	ABC-type spermidine putrescine transport system, permease component I
GH742_RS05880	COG3842	ATPase activity
GH742_RS05915	COG0601	transmembrane transport
GH742_RS05920	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GH742_RS05965	COG0616	signal peptide processing
GH742_RS06005	COG1138	Cytochrome C-type biogenesis protein
GH742_RS06025	COG3360	Dodecin
GH742_RS06040	COG0514	ATP-dependent DNA helicase (RecQ)
GH742_RS06050	COG1024	Enoyl-CoA hydratase
GH742_RS06055	COG1024	Enoyl-CoA hydratase
GH742_RS06170	COG0629	single-stranded DNA binding
GH742_RS06195	COG0456	acetyltransferase
GH742_RS06195	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
GH742_RS06210	COG4974	Belongs to the 'phage' integrase family
GH742_RS06225	COG4584	PFAM Integrase catalytic
GH742_RS06235	COG4974	Belongs to the 'phage' integrase family
GH742_RS06245	COG4584	PFAM Integrase catalytic
GH742_RS06310	COG3328	transposase activity
GH742_RS06425	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
GH742_RS06445	COG0510	thiamine kinase activity
GH742_RS06450	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GH742_RS06450	COG1028	Short-chain dehydrogenase reductase Sdr
GH742_RS06450	COG3321	synthase
GH742_RS06450	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GH742_RS06450	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GH742_RS06455	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GH742_RS06455	COG0300	oxidoreductase activity
GH742_RS06455	COG3321	synthase
GH742_RS06455	COG4221	oxidoreductase activity
GH742_RS06460	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GH742_RS06460	COG0300	oxidoreductase activity
GH742_RS06460	COG3321	synthase
GH742_RS06460	COG4221	oxidoreductase activity
GH742_RS06475	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GH742_RS06480	COG2070	2-Nitropropane dioxygenase
GH742_RS06480	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GH742_RS06495	COG0242	peptide deformylase activity
GH742_RS06525	COG0582	viral genome integration into host DNA
GH742_RS06590	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GH742_RS06600	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GH742_RS06715	COG5507	3-demethylubiquinone-9 3-methyltransferase
GH742_RS06745	COG4943	cyclic-guanylate-specific phosphodiesterase activity
GH742_RS06810	COG3590	peptidase
GH742_RS06815	COG4251	negative regulation of phosphorylation
GH742_RS06825	COG0745	RESPONSE REGULATOR receiver
GH742_RS06830	COG1716	ATPase activity
GH742_RS06830	COG5001	Diguanylate cyclase
GH742_RS06845	COG1132	(ABC) transporter
GH742_RS06865	COG0123	including yeast histone deacetylase and acetoin utilization protein
GH742_RS06880	COG1960	acyl-CoA dehydrogenase activity
GH742_RS06900	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
GH742_RS06990	COG5654	RES domain protein
GH742_RS06995	COG5642	Protein of unknown function (DUF2384)
GH742_RS07000	COG4783	chaperone-mediated protein folding
GH742_RS07005	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GH742_RS07005	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GH742_RS07010	COG0307	riboflavin synthase, alpha
GH742_RS07015	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GH742_RS07015	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GH742_RS07055	COG2974	May be involved in recombination
GH742_RS07065	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GH742_RS07075	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GH742_RS07075	COG0140	phosphoribosyl-ATP diphosphatase activity
GH742_RS07085	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GH742_RS07110	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GH742_RS07150	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
GH742_RS07165	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GH742_RS07175	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GH742_RS07180	COG0512	Glutamine amidotransferase of anthranilate synthase
GH742_RS07180	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GH742_RS07185	COG0038	chloride channel
GH742_RS07195	COG0395	ABC-type sugar transport system, permease component
GH742_RS07200	COG3842	ATPase activity
GH742_RS07210	COG2267	carboxylic ester hydrolase activity
GH742_RS07215	COG1960	acyl-CoA dehydrogenase activity
GH742_RS07225	COG2894	cell division
GH742_RS07240	COG0625	glutathione transferase activity
GH742_RS07315	COG3138	arginine N-succinyltransferase
GH742_RS07355	COG0531	amino acid
GH742_RS07360	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
GH742_RS07390	COG2850	peptidyl-arginine hydroxylation
GH742_RS07400	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
GH742_RS07415	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GH742_RS07450	COG0318	PFAM AMP-dependent synthetase and ligase
GH742_RS07455	COG0850	regulation of cytokinetic process
GH742_RS07485	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GH742_RS07505	COG2976	Protein conserved in bacteria
GH742_RS07520	COG3437	response regulator, receiver
GH742_RS07525	COG0154	amidase activity
GH742_RS07545	COG0861	Integral membrane protein TerC family
GH742_RS07560	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GH742_RS07565	COG0280	phosphate acetyltransferase
GH742_RS07565	COG0857	belongs to the CobB CobQ family
GH742_RS07590	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
GH742_RS07595	COG0372	Belongs to the citrate synthase family
GH742_RS07600	COG2079	MmgE PrpD family protein
GH742_RS07620	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
GH742_RS07630	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GH742_RS07645	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
GH742_RS07650	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GH742_RS07680	COG0586	Pfam SNARE associated Golgi protein
GH742_RS07690	COG2921	Belongs to the UPF0250 family
GH742_RS07700	COG1686	Belongs to the peptidase S11 family
GH742_RS07705	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GH742_RS07720	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
GH742_RS07740	COG0285	dihydrofolate synthase activity
GH742_RS07750	COG1286	toxin biosynthetic process
GH742_RS07775	COG0815	Transfers the fatty acyl group on membrane lipoproteins
GH742_RS07785	COG1012	belongs to the aldehyde dehydrogenase family
GH742_RS07790	COG1250	3-hydroxyacyl-CoA dehydrogenase
GH742_RS07790	COG1024	Enoyl-CoA hydratase
GH742_RS07795	COG0183	Belongs to the thiolase family
GH742_RS07810	COG0531	amino acid
GH742_RS07840	COG2165	general secretion pathway protein
GH742_RS07850	COG0174	glutamine synthetase
GH742_RS07865	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
GH742_RS07900	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GH742_RS07905	COG0673	inositol 2-dehydrogenase activity
GH742_RS07915	COG0772	Belongs to the SEDS family
GH742_RS07920	COG0768	penicillin binding
GH742_RS07940	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
GH742_RS07985	COG0482	sulfurtransferase activity
GH742_RS08005	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GH742_RS08010	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GH742_RS08025	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GH742_RS08030	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GH742_RS08040	COG0470	DNA polymerase III
GH742_RS08050	COG0084	hydrolase, TatD family'
GH742_RS08055	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
GH742_RS08065	COG0666	response to abiotic stimulus
GH742_RS08065	COG3177	Filamentation induced by cAMP protein fic
GH742_RS08095	COG3220	belongs to the UPF0276 family
GH742_RS08105	COG2814	Major facilitator Superfamily
GH742_RS08125	COG0463	Glycosyl transferase, family 2
GH742_RS08150	COG1028	Short-chain dehydrogenase reductase Sdr
GH742_RS08155	COG1028	Short-chain dehydrogenase reductase Sdr
GH742_RS08190	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GH742_RS08195	COG0346	lactoylglutathione lyase activity
GH742_RS08270	COG4221	oxidoreductase activity
GH742_RS08300	COG3264	Mechanosensitive ion channel
GH742_RS08300	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
GH742_RS08330	COG0156	8-amino-7-oxononanoate synthase activity
GH742_RS08345	COG4943	cyclic-guanylate-specific phosphodiesterase activity
GH742_RS08380	COG1215	transferase activity, transferring glycosyl groups
GH742_RS08415	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GH742_RS08420	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GH742_RS08430	COG0436	Aminotransferase
GH742_RS08445	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GH742_RS08460	COG1187	pseudouridine synthase activity
GH742_RS08465	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
GH742_RS08470	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
GH742_RS08475	COG0180	Tryptophanyl-tRNA synthetase
GH742_RS08480	COG0009	L-threonylcarbamoyladenylate synthase
GH742_RS08485	COG0613	PHP domain protein
GH742_RS08490	COG1702	phosphate starvation-inducible protein PhoH
GH742_RS08505	COG0745	RESPONSE REGULATOR receiver
GH742_RS08510	COG2205	protein histidine kinase activity
GH742_RS08530	COG1823	symporter activity
GH742_RS08555	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
GH742_RS08560	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
GH742_RS08585	COG1573	uracil-dna glycosylase
GH742_RS08590	COG4221	oxidoreductase activity
GH742_RS08610	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
GH742_RS08620	COG0539	negative regulation of cytoplasmic translation
GH742_RS08625	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GH742_RS08635	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
GH742_RS08645	COG0372	Belongs to the citrate synthase family
GH742_RS08650	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GH742_RS08670	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GH742_RS08695	COG0456	acetyltransferase
GH742_RS08735	COG0824	Thioesterase
GH742_RS08740	COG2255	four-way junction helicase activity
GH742_RS08760	COG0354	folic acid binding
GH742_RS08765	COG3038	cytochrome b561
GH742_RS08775	COG1376	ErfK ybiS ycfS ynhG family protein
GH742_RS08780	COG1012	belongs to the aldehyde dehydrogenase family
GH742_RS08785	COG1183	phosphatidylcholine synthase activity
GH742_RS08805	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GH742_RS08805	COG3323	Protein of unknown function (DUF1653)
GH742_RS08850	COG1376	ErfK ybiS ycfS ynhG family protein
GH742_RS08855	COG1250	3-hydroxyacyl-CoA dehydrogenase
GH742_RS08855	COG1024	Enoyl-CoA hydratase
GH742_RS08860	COG0183	Belongs to the thiolase family
GH742_RS08900	COG3328	transposase activity
GH742_RS08905	COG1598	PFAM Uncharacterised protein family UPF0150
GH742_RS08925	COG3328	transposase activity
GH742_RS08985	COG3852	Histidine kinase
GH742_RS09045	COG4191	Histidine kinase
GH742_RS09065	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
GH742_RS09070	COG1691	(AIR) carboxylase
GH742_RS09105	COG1671	Belongs to the UPF0178 family
GH742_RS09180	COG0175	sulfate reduction
GH742_RS09205	COG1028	Short-chain dehydrogenase reductase Sdr
GH742_RS09210	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GH742_RS09290	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GH742_RS09305	COG0393	Putative heavy-metal-binding
GH742_RS09395	COG1201	RNA secondary structure unwinding
GH742_RS09430	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GH742_RS09485	COG0477	Major facilitator Superfamily
GH742_RS09495	COG1793	dna ligase
GH742_RS09505	COG2119	membrane
GH742_RS09525	COG3101	peptidyl-lysine hydroxylation
GH742_RS09540	COG0259	pyridoxamine-phosphate oxidase activity
GH742_RS09555	COG2814	Major facilitator Superfamily
GH742_RS09560	COG0800	Aldolase
GH742_RS09565	COG0837	glucose binding
GH742_RS09570	COG0129	dihydroxy-acid dehydratase activity
GH742_RS09580	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GH742_RS09590	COG2226	methyltransferase
GH742_RS09600	COG2814	Major facilitator Superfamily
GH742_RS09605	COG0673	inositol 2-dehydrogenase activity
GH742_RS09610	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GH742_RS09615	COG3962	Belongs to the TPP enzyme family
GH742_RS09625	COG0123	including yeast histone deacetylase and acetoin utilization protein
GH742_RS09635	COG0069	glutamate synthase activity
GH742_RS09640	COG4106	trans-aconitate 2-methyltransferase activity
GH742_RS09675	COG2271	Major facilitator Superfamily
GH742_RS09685	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GH742_RS09690	COG0508	dehydrogenase complex catalyzes the overall conversion of
GH742_RS09725	COG0564	pseudouridine synthase activity
GH742_RS09735	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GH742_RS09765	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GH742_RS09815	COG3237	CsbD-like
GH742_RS09825	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
GH742_RS09840	COG1278	Cold shock
GH742_RS09845	COG1388	LysM domain
GH742_RS09845	COG0741	lytic transglycosylase activity
GH742_RS09855	COG2917	probably involved in intracellular septation
GH742_RS09880	COG0217	transcriptional regulatory protein
GH742_RS09885	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
GH742_RS09915	COG0281	malic enzyme
GH742_RS09940	COG0183	Belongs to the thiolase family
GH742_RS10015	COG1749	Flagellar hook protein flgE
GH742_RS10020	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
GH742_RS10025	COG1558	bacterial-type flagellum-dependent cell motility
GH742_RS10030	COG1815	bacterial-type flagellum-dependent cell motility
GH742_RS10055	COG0300	oxidoreductase activity
GH742_RS10130	COG2226	methyltransferase
GH742_RS10130	COG2867	negative regulation of translational initiation
GH742_RS10165	COG0626	cystathionine gamma-synthase activity
GH742_RS10170	COG0204	Acyl-transferase
GH742_RS10215	COG1301	dicarboxylic acid transport
GH742_RS10245	COG0488	(ABC) transporter
GH742_RS10250	COG0833	amino acid
GH742_RS10260	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GH742_RS10260	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GH742_RS10275	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
GH742_RS10310	COG5007	Belongs to the BolA IbaG family
GH742_RS10330	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GH742_RS10335	COG1127	ABC transporter
GH742_RS10345	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
GH742_RS10360	COG1137	ATPase activity
GH742_RS10380	COG3300	MHYT domain
GH742_RS10380	COG5001	Diguanylate cyclase
GH742_RS10425	COG0705	Rhomboid family
GH742_RS10445	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GH742_RS10450	COG1022	Amp-dependent synthetase and ligase
GH742_RS10455	COG0312	modulator of DNA gyrase
GH742_RS10460	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GH742_RS10465	COG0670	Belongs to the BI1 family
GH742_RS10475	COG3550	peptidyl-serine autophosphorylation
GH742_RS10480	COG1013	pyruvate-flavodoxin oxidoreductase activity
GH742_RS10485	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
GH742_RS10485	COG0674	pyruvate-flavodoxin oxidoreductase activity
GH742_RS10540	COG0196	riboflavin kinase activity
GH742_RS10555	COG0589	response to stress
GH742_RS10620	COG0686	Belongs to the AlaDH PNT family
GH742_RS10635	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GH742_RS10665	COG0463	Glycosyl transferase, family 2
GH742_RS10675	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
GH742_RS10680	COG1994	Peptidase M50
GH742_RS10730	COG0316	Belongs to the HesB IscA family
GH742_RS10740	COG1104	cysteine desulfurase activity
GH742_RS10745	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
GH742_RS10780	COG0542	response to heat
GH742_RS10795	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GH742_RS10825	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GH742_RS10835	COG1677	Flagellar hook-basal body complex protein FliE
GH742_RS10850	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GH742_RS10860	COG1674	ftsk spoiiie
GH742_RS10865	COG0492	ferredoxin-NADP+ reductase activity
GH742_RS10880	COG0312	modulator of DNA gyrase
GH742_RS10890	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GH742_RS10890	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GH742_RS10945	COG1058	Belongs to the CinA family
GH742_RS10945	COG1546	Belongs to the CinA family
GH742_RS10965	COG0729	surface antigen
GH742_RS10975	COG0113	porphobilinogen synthase activity
GH742_RS10990	COG0527	aspartate kinase activity
GH742_RS10995	COG1074	ATP-dependent DNA helicase activity
GH742_RS11000	COG0531	amino acid
GH742_RS11005	COG0489	protein tyrosine kinase activity
GH742_RS11030	COG1301	dicarboxylic acid transport
GH742_RS11045	COG0783	Belongs to the Dps family
GH742_RS11065	COG4232	protein-disulfide reductase activity
GH742_RS11080	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
GH742_RS11110	COG0628	permease
GH742_RS11115	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
GH742_RS11140	COG2823	Periplasmic or secreted lipoprotein
GH742_RS11155	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GH742_RS11160	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GH742_RS11165	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GH742_RS11205	COG1297	OPT oligopeptide transporter protein
GH742_RS11220	COG1028	Short-chain dehydrogenase reductase Sdr
GH742_RS11225	COG0010	Belongs to the arginase family
GH742_RS11245	COG0488	(ABC) transporter
GH742_RS11255	COG0156	8-amino-7-oxononanoate synthase activity
GH742_RS11260	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GH742_RS11265	COG1538	Outer membrane efflux protein
GH742_RS11275	COG0659	secondary active sulfate transmembrane transporter activity
GH742_RS11280	COG0583	DNA-binding transcription factor activity
GH742_RS11300	COG0583	DNA-binding transcription factor activity
GH742_RS11320	COG1132	(ABC) transporter
GH742_RS11355	COG2815	serine threonine protein kinase
GH742_RS11355	COG0515	serine threonine protein kinase
GH742_RS11365	COG1960	acyl-CoA dehydrogenase activity
GH742_RS11370	COG0183	Belongs to the thiolase family
GH742_RS11380	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GH742_RS11405	COG1166	arginine decarboxylase activity
GH742_RS11415	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GH742_RS11465	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GH742_RS11470	COG2011	ABC-type metal ion transport system permease component
GH742_RS11475	COG1464	Belongs to the NlpA lipoprotein family
GH742_RS11495	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GH742_RS11500	COG0751	glycine-tRNA ligase activity
GH742_RS11515	COG0210	DNA helicase
GH742_RS11530	COG2853	Lipoprotein
GH742_RS11535	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
GH742_RS11540	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GH742_RS11545	COG0189	ligase activity
GH742_RS11565	COG1054	Belongs to the UPF0176 family
GH742_RS11585	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GH742_RS11590	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GH742_RS11595	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
GH742_RS11640	COG0546	phosphoglycolate phosphatase activity
GH742_RS11645	COG0564	pseudouridine synthase activity
GH742_RS11650	COG1530	ribonuclease E activity
GH742_RS11675	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GH742_RS11695	COG2815	serine threonine protein kinase
GH742_RS11695	COG0515	serine threonine protein kinase
GH742_RS11705	COG0572	uridine kinase
GH742_RS11740	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GH742_RS11785	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GH742_RS11805	COG0488	(ABC) transporter
GH742_RS11810	COG3577	Aspartyl protease
GH742_RS11820	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GH742_RS11835	COG1561	YicC-like family, N-terminal region
GH742_RS11860	COG0762	integral membrane protein
GH742_RS11875	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GH742_RS11880	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GH742_RS11890	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
GH742_RS11900	COG0505	Belongs to the CarA family
GH742_RS11910	COG0443	Heat shock 70 kDa protein
GH742_RS11920	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
GH742_RS11925	COG0429	hydrolase of the alpha beta-hydrolase fold
GH742_RS11945	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GH742_RS11950	COG2217	Heavy metal translocating P-type atpase
GH742_RS11985	COG0628	permease
GH742_RS12005	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GH742_RS12015	COG0424	maF-like protein
GH742_RS12035	COG1722	exodeoxyribonuclease VII activity
GH742_RS12040	COG0142	geranyltranstransferase activity
GH742_RS12045	COG3475	LICD family
GH742_RS12050	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GH742_RS12055	COG0668	transmembrane transport
GH742_RS12060	COG1058	Belongs to the CinA family
GH742_RS12060	COG1546	Belongs to the CinA family
GH742_RS12065	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GH742_RS12090	COG0012	GTP binding
GH742_RS12110	COG0142	geranyltranstransferase activity
GH742_RS12125	COG3311	Transcriptional regulator
GH742_RS12135	COG1028	Short-chain dehydrogenase reductase Sdr
GH742_RS12145	COG1993	acr, cog1993
GH742_RS12155	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GH742_RS12160	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GH742_RS12165	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GH742_RS12185	COG0575	Belongs to the CDS family
GH742_RS12195	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GH742_RS12200	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
GH742_RS12205	COG4942	peptidase
GH742_RS12210	COG0793	Belongs to the peptidase S41A family
GH742_RS12220	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
GH742_RS12255	COG0330	HflC and HflK could
GH742_RS12260	COG0330	HflC and HflK could
GH742_RS12270	COG1363	Peptidase, m42
GH742_RS12310	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GH742_RS12325	COG1183	phosphatidylcholine synthase activity
GH742_RS12340	COG0633	Ferredoxin
GH742_RS12340	COG0543	2 iron, 2 sulfur cluster binding
GH742_RS12345	COG3588	fructose-bisphosphate aldolase
GH742_RS12350	COG3568	Endonuclease Exonuclease Phosphatase
GH742_RS12360	COG3227	Zinc metalloprotease (Elastase)
GH742_RS12365	COG0009	L-threonylcarbamoyladenylate synthase
GH742_RS12380	COG0511	ligase activity, forming carbon-carbon bonds
GH742_RS12385	COG0439	Biotin carboxylase
GH742_RS12390	COG2264	protein methyltransferase activity
GH742_RS12395	COG0138	bifunctional purine biosynthesis protein purh
GH742_RS12410	COG3300	MHYT domain
GH742_RS12410	COG5001	Diguanylate cyclase
GH742_RS12425	COG0494	nUDIX hydrolase
GH742_RS12430	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GH742_RS12440	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GH742_RS12455	COG0358	DNA primase activity
GH742_RS12500	COG2217	Heavy metal translocating P-type atpase
GH742_RS12505	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GH742_RS12520	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
GH742_RS12530	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
GH742_RS12540	COG2199	diguanylate cyclase activity
GH742_RS12540	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GH742_RS12550	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
GH742_RS12550	COG0456	acetyltransferase
GH742_RS12555	COG1132	(ABC) transporter
GH742_RS12585	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GH742_RS12585	COG4651	solute:proton antiporter activity
GH742_RS12590	COG0142	geranyltranstransferase activity
GH742_RS12610	COG0494	nUDIX hydrolase
GH742_RS12625	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GH742_RS12630	COG2153	protein acetylation
GH742_RS12635	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GH742_RS12640	COG1181	Belongs to the D-alanine--D-alanine ligase family
GH742_RS12640	COG2918	glutathione biosynthetic process
GH742_RS12645	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GH742_RS12655	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GH742_RS12655	COG0473	3-isopropylmalate dehydrogenase activity
GH742_RS12695	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GH742_RS12730	COG0583	DNA-binding transcription factor activity
GH742_RS12745	COG2124	cytochrome p450
GH742_RS12760	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
GH742_RS12770	COG1597	lipid kinase activity
GH742_RS12780	COG0842	Transport permease protein
GH742_RS12785	COG1131	(ABC) transporter
GH742_RS12795	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GH742_RS12800	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GH742_RS12805	COG1438	arginine binding
GH742_RS12810	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GH742_RS12815	COG0765	amino acid transport
GH742_RS12820	COG1126	abc transporter atp-binding protein
GH742_RS12825	COG0137	argininosuccinate synthase activity
GH742_RS12835	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GH742_RS12935	COG4566	intracellular signal transduction
GH742_RS12940	COG4566	intracellular signal transduction
GH742_RS12980	COG0739	heme binding
GH742_RS13000	COG0700	Nucleoside recognition
GH742_RS13005	COG2715	membrane protein required for spore maturation
GH742_RS13020	COG2885	chlorophyll binding
GH742_RS13025	COG0814	amino acid
GH742_RS13030	COG0814	amino acid
GH742_RS13040	COG0338	D12 class N6 adenine-specific DNA methyltransferase
GH742_RS13050	COG2223	nitrite transmembrane transporter activity
GH742_RS13055	COG0281	malic enzyme
GH742_RS13065	COG0288	reversible hydration of carbon dioxide
GH742_RS13070	COG0708	Exodeoxyribonuclease III
GH742_RS13075	COG0708	Exodeoxyribonuclease III
GH742_RS13120	COG0659	secondary active sulfate transmembrane transporter activity
GH742_RS13140	COG0735	belongs to the Fur family
GH742_RS13165	COG0693	protein deglycase activity
GH742_RS13170	COG1546	Belongs to the CinA family
GH742_RS13180	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GH742_RS13180	COG2198	Histidine kinase
GH742_RS13180	COG0784	Response regulator, receiver
GH742_RS13180	COG2205	protein histidine kinase activity
GH742_RS13190	COG1181	Belongs to the D-alanine--D-alanine ligase family
GH742_RS13190	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GH742_RS13215	COG0861	Integral membrane protein TerC family
GH742_RS13225	COG1064	alcohol dehydrogenase
GH742_RS13285	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GH742_RS13300	COG1162	GTPase activity
GH742_RS13340	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
GH742_RS13345	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GH742_RS13350	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GH742_RS13390	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GH742_RS13395	COG4536	flavin adenine dinucleotide binding
GH742_RS13400	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GH742_RS13415	COG0336	Belongs to the RNA methyltransferase TrmD family
GH742_RS13425	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GH742_RS13445	COG1131	(ABC) transporter
GH742_RS13450	COG0842	Transport permease protein
GH742_RS13470	COG0501	Belongs to the peptidase M48B family
GH742_RS13475	COG1704	LemA family
GH742_RS13480	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GH742_RS13520	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
GH742_RS13535	COG0433	COG0433 Predicted ATPase
GH742_RS13540	COG0735	belongs to the Fur family
GH742_RS13555	COG2867	negative regulation of translational initiation
GH742_RS13580	COG0569	domain protein
GH742_RS13600	COG3237	CsbD-like
GH742_RS13610	COG1983	PspC domain protein
GH742_RS13625	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GH742_RS13635	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GH742_RS13650	COG1028	Short-chain dehydrogenase reductase Sdr
GH742_RS13655	COG2814	Major facilitator Superfamily
GH742_RS13660	COG0629	single-stranded DNA binding
GH742_RS13840	COG0085	RNA polymerase activity
GH742_RS13845	COG0222	ribosome binding
GH742_RS13870	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GH742_RS13940	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
GH742_RS13945	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GH742_RS13960	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GH742_RS13970	COG1960	acyl-CoA dehydrogenase activity
GH742_RS13995	COG1509	lysine 2,3-aminomutase activity
GH742_RS14000	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GH742_RS14035	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
GH742_RS14065	COG4953	penicillin-binding protein 1C
GH742_RS14105	COG0859	PFAM glycosyl transferase family 9
GH742_RS14125	COG1028	Short-chain dehydrogenase reductase Sdr
GH742_RS14140	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GH742_RS14175	COG0028	Belongs to the TPP enzyme family
GH742_RS14195	COG1073	alpha beta
GH742_RS14210	COG0776	regulation of translation
GH742_RS14225	COG0330	HflC and HflK could
GH742_RS14250	COG2885	chlorophyll binding
GH742_RS14255	COG0418	dihydroorotase activity
GH742_RS14265	COG0450	alkyl hydroperoxide reductase
GH742_RS14270	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
GH742_RS14275	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GH742_RS14280	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GH742_RS14285	COG1234	tRNA 3'-trailer cleavage
GH742_RS14305	COG0659	secondary active sulfate transmembrane transporter activity
GH742_RS14320	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GH742_RS14325	COG0557	exoribonuclease II activity
GH742_RS14335	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GH742_RS14350	COG1114	Component of the transport system for branched-chain amino acids
GH742_RS14365	COG4067	protein conserved in archaea
GH742_RS14365	COG0189	ligase activity
GH742_RS14385	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GH742_RS14400	COG0805	protein transport
GH742_RS14420	COG0543	2 iron, 2 sulfur cluster binding
GH742_RS14420	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GH742_RS14440	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
GH742_RS14450	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GH742_RS14455	COG0531	amino acid
GH742_RS14465	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GH742_RS14505	COG0688	phosphatidylethanolamine metabolic process
GH742_RS14520	COG0477	Major facilitator Superfamily
GH742_RS14530	COG3227	Zinc metalloprotease (Elastase)
GH742_RS14590	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GH742_RS14605	COG0356	it plays a direct role in the translocation of protons across the membrane
GH742_RS14630	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GH742_RS14635	COG0792	nuclease activity
GH742_RS14640	COG3107	peptidoglycan biosynthetic process
GH742_RS14645	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
GH742_RS14720	COG2217	Heavy metal translocating P-type atpase
GH742_RS14725	COG2203	Gaf domain
GH742_RS14725	COG2199	diguanylate cyclase activity
GH742_RS14770	COG2132	Multicopper oxidase
GH742_RS14775	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GH742_RS14810	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GH742_RS14825	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GH742_RS14825	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GH742_RS14850	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GH742_RS14880	COG1028	Short-chain dehydrogenase reductase Sdr
GH742_RS14885	COG1278	Cold shock
GH742_RS14920	COG0789	Transcriptional regulator
GH742_RS14945	COG4983	Phage plasmid primase, P4 family domain protein
GH742_RS14970	COG3293	Transposase
GH742_RS14980	COG3344	reverse transcriptase
GH742_RS15020	COG0640	Transcriptional regulator
GH742_RS15100	COG0640	Transcriptional regulator
GH742_RS15105	COG3077	Addiction module antitoxin, RelB DinJ family
GH742_RS15110	COG3041	Addiction module toxin RelE StbE family
GH742_RS15150	COG4584	PFAM Integrase catalytic
GH742_RS15155	COG4584	PFAM Integrase catalytic
GH742_RS15155	COG2390	Transcriptional regulator
GH742_RS15180	COG1476	TRANSCRIPTIONal
GH742_RS15220	COG2801	Transposase and inactivated derivatives
GH742_RS15245	COG3335	DDE superfamily endonuclease
GH742_RS15255	COG1475	DNA binding
GH742_RS15270	COG1475	DNA binding
GH742_RS15280	COG4974	Belongs to the 'phage' integrase family
GH742_RS15285	COG2137	regulation of response to DNA damage stimulus
GH742_RS15305	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GH742_RS15310	COG1396	sequence-specific DNA binding
GH742_RS15320	COG0442	prolyl-tRNA aminoacylation
GH742_RS15325	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GH742_RS15350	COG1619	proteins homologs of microcin C7 resistance protein MccF
GH742_RS15370	COG0456	acetyltransferase
GH742_RS15380	COG4221	oxidoreductase activity
GH742_RS15405	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GH742_RS15415	COG4584	PFAM Integrase catalytic
GH742_RS15465	COG0745	RESPONSE REGULATOR receiver
GH742_RS15470	COG1181	Belongs to the D-alanine--D-alanine ligase family
GH742_RS15470	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GH742_RS15505	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
GH742_RS15520	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GH742_RS15525	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
GH742_RS15535	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)