locus-tag	class	description
HBNCFIEN_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HBNCFIEN_RS00020	COG0187	DNA topoisomerase II activity
HBNCFIEN_RS00035	COG1166	arginine decarboxylase activity
HBNCFIEN_RS00065	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HBNCFIEN_RS00070	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HBNCFIEN_RS00090	COG1741	Belongs to the pirin family
HBNCFIEN_RS00110	COG3227	Zinc metalloprotease (Elastase)
HBNCFIEN_RS00145	COG0531	amino acid
HBNCFIEN_RS00155	COG0306	phosphate transporter
HBNCFIEN_RS00170	COG2205	protein histidine kinase activity
HBNCFIEN_RS00170	COG0784	Response regulator, receiver
HBNCFIEN_RS00175	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HBNCFIEN_RS00180	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HBNCFIEN_RS00185	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HBNCFIEN_RS00190	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HBNCFIEN_RS00195	COG0450	alkyl hydroperoxide reductase
HBNCFIEN_RS00200	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HBNCFIEN_RS00205	COG0418	dihydroorotase activity
HBNCFIEN_RS00230	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HBNCFIEN_RS00240	COG0330	HflC and HflK could
HBNCFIEN_RS00250	COG2226	methyltransferase
HBNCFIEN_RS00260	COG0776	regulation of translation
HBNCFIEN_RS00295	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HBNCFIEN_RS00315	COG0543	2 iron, 2 sulfur cluster binding
HBNCFIEN_RS00315	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HBNCFIEN_RS00335	COG0805	protein transport
HBNCFIEN_RS00375	COG1136	(ABC) transporter
HBNCFIEN_RS00375	COG0577	efflux transmembrane transporter activity
HBNCFIEN_RS00390	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HBNCFIEN_RS00405	COG2124	cytochrome p450
HBNCFIEN_RS00420	COG0583	DNA-binding transcription factor activity
HBNCFIEN_RS00440	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HBNCFIEN_RS00470	COG2010	Cytochrome c
HBNCFIEN_RS00470	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HBNCFIEN_RS00475	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HBNCFIEN_RS00480	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HBNCFIEN_RS00485	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
HBNCFIEN_RS00490	COG1845	cytochrome c oxidase, subunit III
HBNCFIEN_RS00500	COG1475	DNA binding
HBNCFIEN_RS00505	COG1192	Involved in chromosome partitioning
HBNCFIEN_RS00510	COG0357	Ribosomal RNA small subunit methyltransferase G
HBNCFIEN_RS00560	COG0714	Associated with various cellular activities
HBNCFIEN_RS00585	COG1028	Short-chain dehydrogenase reductase Sdr
HBNCFIEN_RS00600	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HBNCFIEN_RS00620	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
HBNCFIEN_RS00630	COG0252	asparaginase activity
HBNCFIEN_RS00660	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HBNCFIEN_RS00720	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HBNCFIEN_RS00725	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HBNCFIEN_RS00750	COG2183	response to ionizing radiation
HBNCFIEN_RS00765	COG0307	riboflavin synthase, alpha
HBNCFIEN_RS00785	COG0110	maltose O-acetyltransferase activity
HBNCFIEN_RS00790	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HBNCFIEN_RS00805	COG1063	alcohol dehydrogenase
HBNCFIEN_RS00820	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HBNCFIEN_RS00825	COG0297	glycogen (starch) synthase activity
HBNCFIEN_RS00840	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HBNCFIEN_RS00850	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HBNCFIEN_RS00870	COG1088	dTDP-glucose 4,6-dehydratase activity
HBNCFIEN_RS00875	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HBNCFIEN_RS00885	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HBNCFIEN_RS00885	COG2755	lipolytic protein G-D-S-L family
HBNCFIEN_RS00895	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HBNCFIEN_RS00905	COG1028	Short-chain dehydrogenase reductase Sdr
HBNCFIEN_RS00925	COG2226	methyltransferase
HBNCFIEN_RS00945	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HBNCFIEN_RS00965	COG0431	NADPH-dependent FMN reductase
HBNCFIEN_RS00975	COG0477	Major facilitator Superfamily
HBNCFIEN_RS00980	COG0210	DNA helicase
HBNCFIEN_RS00990	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HBNCFIEN_RS01010	COG0497	DNA recombination
HBNCFIEN_RS01015	COG0726	polysaccharide deacetylase
HBNCFIEN_RS01040	COG2719	SpoVR family
HBNCFIEN_RS01050	COG2766	serine protein kinase
HBNCFIEN_RS01055	COG0308	aminopeptidase N
HBNCFIEN_RS01080	COG3104	oligopeptide transport
HBNCFIEN_RS01095	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HBNCFIEN_RS01115	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HBNCFIEN_RS01120	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HBNCFIEN_RS01130	COG0149	triose-phosphate isomerase activity
HBNCFIEN_RS01145	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HBNCFIEN_RS01155	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HBNCFIEN_RS01170	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HBNCFIEN_RS01175	COG1034	ATP synthesis coupled electron transport
HBNCFIEN_RS01180	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HBNCFIEN_RS01225	COG0195	Participates in both transcription termination and antitermination
HBNCFIEN_RS01225	COG2251	uridine kinase activity
HBNCFIEN_RS01240	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HBNCFIEN_RS01255	COG0302	gtp cyclohydrolase
HBNCFIEN_RS01260	COG0537	adenosine 5'-monophosphoramidase activity
HBNCFIEN_RS01265	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HBNCFIEN_RS01270	COG4536	flavin adenine dinucleotide binding
HBNCFIEN_RS01340	COG1162	GTPase activity
HBNCFIEN_RS01355	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HBNCFIEN_RS01370	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HBNCFIEN_RS01405	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
HBNCFIEN_RS01430	COG0343	queuine tRNA-ribosyltransferase activity
HBNCFIEN_RS01435	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HBNCFIEN_RS01440	COG2860	membrane
HBNCFIEN_RS01455	COG1846	Transcriptional regulator
HBNCFIEN_RS01500	COG0776	regulation of translation
HBNCFIEN_RS01515	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HBNCFIEN_RS01520	COG0723	plastoquinol--plastocyanin reductase activity
HBNCFIEN_RS01525	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HBNCFIEN_RS01530	COG2857	Cytochrome c1
HBNCFIEN_RS01535	COG0625	glutathione transferase activity
HBNCFIEN_RS01540	COG2969	positive regulation of protein catabolic process
HBNCFIEN_RS01545	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HBNCFIEN_RS01545	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HBNCFIEN_RS01555	COG0860	N-Acetylmuramoyl-L-alanine amidase
HBNCFIEN_RS01560	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HBNCFIEN_RS01575	COG0859	PFAM glycosyl transferase family 9
HBNCFIEN_RS01580	COG2608	mercury ion transmembrane transporter activity
HBNCFIEN_RS01580	COG2217	Heavy metal translocating P-type atpase
HBNCFIEN_RS01610	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HBNCFIEN_RS01630	COG0742	ribosomal rna small subunit methyltransferase
HBNCFIEN_RS01635	COG0612	Peptidase, M16
HBNCFIEN_RS01640	COG0612	Peptidase, M16
HBNCFIEN_RS01645	COG0552	protein localization to endoplasmic reticulum
HBNCFIEN_RS01650	COG2884	Cell division ATP-binding protein ftsE
HBNCFIEN_RS01655	COG2177	Part of the ABC transporter FtsEX involved in
HBNCFIEN_RS01695	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HBNCFIEN_RS01720	COG2009	succinate dehydrogenase
HBNCFIEN_RS01725	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HBNCFIEN_RS01735	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HBNCFIEN_RS01740	COG0567	Dehydrogenase, E1 component
HBNCFIEN_RS01745	COG0508	dehydrogenase complex catalyzes the overall conversion of
HBNCFIEN_RS01775	COG2814	Major facilitator Superfamily
HBNCFIEN_RS01785	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
HBNCFIEN_RS01790	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HBNCFIEN_RS01800	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
HBNCFIEN_RS01825	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HBNCFIEN_RS01840	COG1028	Short-chain dehydrogenase reductase Sdr
HBNCFIEN_RS01845	COG1028	Short-chain dehydrogenase reductase Sdr
HBNCFIEN_RS01850	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
HBNCFIEN_RS01860	COG0795	lipopolysaccharide-transporting ATPase activity
HBNCFIEN_RS01865	COG0795	lipopolysaccharide-transporting ATPase activity
HBNCFIEN_RS01875	COG2081	HI0933 family
HBNCFIEN_RS01890	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HBNCFIEN_RS01905	COG0745	RESPONSE REGULATOR receiver
HBNCFIEN_RS01945	COG0719	Fe-S assembly protein
HBNCFIEN_RS01950	COG0396	ATPase activity
HBNCFIEN_RS01955	COG0719	Fe-S assembly protein
HBNCFIEN_RS01960	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HBNCFIEN_RS01965	COG0822	iron-sulfur transferase activity
HBNCFIEN_RS01970	COG2151	metal-sulfur cluster biosynthetic enzyme
HBNCFIEN_RS01985	COG2003	Belongs to the UPF0758 family
HBNCFIEN_RS01990	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HBNCFIEN_RS01995	COG0756	dUTP diphosphatase activity
HBNCFIEN_RS02025	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HBNCFIEN_RS02035	COG4221	oxidoreductase activity
HBNCFIEN_RS02035	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HBNCFIEN_RS02035	COG3321	synthase
HBNCFIEN_RS02035	COG0300	oxidoreductase activity
HBNCFIEN_RS02055	COG0697	spore germination
HBNCFIEN_RS02065	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HBNCFIEN_RS02090	COG0463	Glycosyl transferase, family 2
HBNCFIEN_RS02100	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HBNCFIEN_RS02115	COG1280	lysine exporter protein (LysE YggA)
HBNCFIEN_RS02120	COG3384	dioxygenase
HBNCFIEN_RS02125	COG2867	negative regulation of translational initiation
HBNCFIEN_RS02125	COG2226	methyltransferase
HBNCFIEN_RS02170	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
HBNCFIEN_RS02175	COG4251	negative regulation of phosphorylation
HBNCFIEN_RS02210	COG2199	diguanylate cyclase activity
HBNCFIEN_RS02210	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HBNCFIEN_RS02220	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HBNCFIEN_RS02225	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HBNCFIEN_RS02240	COG0598	Magnesium transport protein CorA
HBNCFIEN_RS02250	COG1304	FMN binding
HBNCFIEN_RS02270	COG0436	Aminotransferase
HBNCFIEN_RS02275	COG1605	Chorismate mutase
HBNCFIEN_RS02275	COG0077	Prephenate dehydratase
HBNCFIEN_RS02280	COG0077	Prephenate dehydratase
HBNCFIEN_RS02300	COG0025	NhaP-type Na H and K H
HBNCFIEN_RS02385	COG4221	oxidoreductase activity
HBNCFIEN_RS02385	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HBNCFIEN_RS02385	COG0300	oxidoreductase activity
HBNCFIEN_RS02385	COG3321	synthase
HBNCFIEN_RS02390	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HBNCFIEN_RS02390	COG0300	oxidoreductase activity
HBNCFIEN_RS02390	COG3321	synthase
HBNCFIEN_RS02390	COG4221	oxidoreductase activity
HBNCFIEN_RS02395	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HBNCFIEN_RS02395	COG3321	synthase
HBNCFIEN_RS02395	COG4221	oxidoreductase activity
HBNCFIEN_RS02395	COG0300	oxidoreductase activity
HBNCFIEN_RS02415	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HBNCFIEN_RS02435	COG0666	response to abiotic stimulus
HBNCFIEN_RS02505	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HBNCFIEN_RS02515	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HBNCFIEN_RS02535	COG0531	amino acid
HBNCFIEN_RS02555	COG2267	carboxylic ester hydrolase activity
HBNCFIEN_RS02610	COG3177	Filamentation induced by cAMP protein fic
HBNCFIEN_RS02610	COG0666	response to abiotic stimulus
HBNCFIEN_RS02615	COG0666	response to abiotic stimulus
HBNCFIEN_RS02615	COG3177	Filamentation induced by cAMP protein fic
HBNCFIEN_RS02685	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HBNCFIEN_RS02690	COG2801	Transposase and inactivated derivatives
HBNCFIEN_RS02710	COG0582	viral genome integration into host DNA
HBNCFIEN_RS02785	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HBNCFIEN_RS02790	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HBNCFIEN_RS02800	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HBNCFIEN_RS02805	COG0183	Belongs to the thiolase family
HBNCFIEN_RS02810	COG1028	Short-chain dehydrogenase reductase Sdr
HBNCFIEN_RS02815	COG3243	poly(R)-hydroxyalkanoic acid synthase
HBNCFIEN_RS02825	COG1063	alcohol dehydrogenase
HBNCFIEN_RS02930	COG3846	protein secretion by the type IV secretion system
HBNCFIEN_RS02945	COG2948	multi-organism process
HBNCFIEN_RS02965	COG3451	type IV secretory pathway VirB4
HBNCFIEN_RS02980	COG4962	Type ii secretion system protein e
HBNCFIEN_RS02985	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HBNCFIEN_RS03025	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HBNCFIEN_RS03035	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HBNCFIEN_RS03085	COG0358	DNA primase activity
HBNCFIEN_RS03090	COG1610	YqeY-like protein
HBNCFIEN_RS03115	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HBNCFIEN_RS03135	COG0446	pyridine nucleotide-disulphide oxidoreductase
HBNCFIEN_RS03135	COG1902	pentaerythritol trinitrate reductase activity
HBNCFIEN_RS03140	COG0513	Belongs to the DEAD box helicase family
HBNCFIEN_RS03150	COG3240	lipase activity
HBNCFIEN_RS03160	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HBNCFIEN_RS03165	COG1519	Transferase
HBNCFIEN_RS03170	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HBNCFIEN_RS03175	COG2890	protein-(glutamine-N5) methyltransferase activity
HBNCFIEN_RS03205	COG1040	competence protein
HBNCFIEN_RS03210	COG2226	methyltransferase
HBNCFIEN_RS03215	COG0415	Belongs to the DNA photolyase family
HBNCFIEN_RS03220	COG0142	geranyltranstransferase activity
HBNCFIEN_RS03265	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HBNCFIEN_RS03275	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
HBNCFIEN_RS03280	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HBNCFIEN_RS03285	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HBNCFIEN_RS03305	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HBNCFIEN_RS03320	COG5487	UPF0391 membrane protein
HBNCFIEN_RS03325	COG1064	alcohol dehydrogenase
HBNCFIEN_RS03335	COG1530	ribonuclease E activity
HBNCFIEN_RS03345	COG0564	pseudouridine synthase activity
HBNCFIEN_RS03350	COG0546	phosphoglycolate phosphatase activity
HBNCFIEN_RS03385	COG4591	ABC-type transport system involved in lipoprotein release permease component
HBNCFIEN_RS03415	COG0625	glutathione transferase activity
HBNCFIEN_RS03445	COG0584	glycerophosphoryl diester phosphodiesterase
HBNCFIEN_RS03475	COG0741	lytic transglycosylase activity
HBNCFIEN_RS03480	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HBNCFIEN_RS03495	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HBNCFIEN_RS03500	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HBNCFIEN_RS03515	COG1063	alcohol dehydrogenase
HBNCFIEN_RS03520	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HBNCFIEN_RS03520	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HBNCFIEN_RS03525	COG4232	protein-disulfide reductase activity
HBNCFIEN_RS03540	COG0783	Belongs to the Dps family
HBNCFIEN_RS03555	COG4689	acetoacetate decarboxylase
HBNCFIEN_RS03565	COG1028	Short-chain dehydrogenase reductase Sdr
HBNCFIEN_RS03605	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HBNCFIEN_RS03615	COG1388	LysM domain
HBNCFIEN_RS03620	COG0758	DNA mediated transformation
HBNCFIEN_RS03645	COG1960	acyl-CoA dehydrogenase activity
HBNCFIEN_RS03710	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HBNCFIEN_RS03750	COG3706	GGDEF domain
HBNCFIEN_RS03755	COG0745	RESPONSE REGULATOR receiver
HBNCFIEN_RS03800	COG0436	Aminotransferase
HBNCFIEN_RS03805	COG5212	phosphodiesterase
HBNCFIEN_RS03810	COG0572	uridine kinase
HBNCFIEN_RS03860	COG2814	Major facilitator Superfamily
HBNCFIEN_RS03880	COG5001	Diguanylate cyclase
HBNCFIEN_RS03880	COG4251	negative regulation of phosphorylation
HBNCFIEN_RS03880	COG2203	Gaf domain
HBNCFIEN_RS03880	COG3706	GGDEF domain
HBNCFIEN_RS03890	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HBNCFIEN_RS03910	COG0784	Response regulator, receiver
HBNCFIEN_RS03935	COG1522	sequence-specific DNA binding
HBNCFIEN_RS03950	COG3436	PFAM IS66 Orf2 family protein
HBNCFIEN_RS03995	COG1346	cytolysis
HBNCFIEN_RS04000	COG1380	Effector of murein hydrolase LrgA
HBNCFIEN_RS04005	COG0583	DNA-binding transcription factor activity
HBNCFIEN_RS04050	COG4191	Histidine kinase
HBNCFIEN_RS04060	COG4566	intracellular signal transduction
HBNCFIEN_RS04070	COG0071	Belongs to the small heat shock protein (HSP20) family
HBNCFIEN_RS04080	COG0662	Cupin 2, conserved barrel domain protein
HBNCFIEN_RS04080	COG2207	Transcriptional regulator
HBNCFIEN_RS04105	COG0500	methyltransferase
HBNCFIEN_RS04105	COG3615	Tellurite resistance protein tehB
HBNCFIEN_RS04110	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HBNCFIEN_RS04140	COG2226	methyltransferase
HBNCFIEN_RS04155	COG2217	Heavy metal translocating P-type atpase
HBNCFIEN_RS04175	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HBNCFIEN_RS04200	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HBNCFIEN_RS04220	COG0589	response to stress
HBNCFIEN_RS04225	COG1902	pentaerythritol trinitrate reductase activity
HBNCFIEN_RS04280	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HBNCFIEN_RS04310	COG3220	belongs to the UPF0276 family
HBNCFIEN_RS04325	COG0586	Pfam SNARE associated Golgi protein
HBNCFIEN_RS04335	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HBNCFIEN_RS04345	COG4172	Belongs to the ABC transporter superfamily
HBNCFIEN_RS04370	COG1872	DUF167
HBNCFIEN_RS04375	COG0432	Pfam Uncharacterised protein family UPF0047
HBNCFIEN_RS04380	COG2824	Alkylphosphonate utilization operon protein PhnA
HBNCFIEN_RS04395	COG0726	polysaccharide deacetylase
HBNCFIEN_RS04405	COG1215	transferase activity, transferring glycosyl groups
HBNCFIEN_RS04420	COG0628	permease
HBNCFIEN_RS04440	COG1201	RNA secondary structure unwinding
HBNCFIEN_RS04475	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
HBNCFIEN_RS04485	COG2070	2-Nitropropane dioxygenase
HBNCFIEN_RS04530	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HBNCFIEN_RS04590	COG1404	Belongs to the peptidase S8 family
HBNCFIEN_RS04610	COG0659	secondary active sulfate transmembrane transporter activity
HBNCFIEN_RS04615	COG0037	tRNA processing
HBNCFIEN_RS04620	COG1538	Outer membrane efflux protein
HBNCFIEN_RS04625	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HBNCFIEN_RS04630	COG0156	8-amino-7-oxononanoate synthase activity
HBNCFIEN_RS04640	COG0488	(ABC) transporter
HBNCFIEN_RS04685	COG1028	Short-chain dehydrogenase reductase Sdr
HBNCFIEN_RS04700	COG1297	OPT oligopeptide transporter protein
HBNCFIEN_RS04710	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HBNCFIEN_RS04715	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HBNCFIEN_RS04755	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HBNCFIEN_RS04760	COG0628	permease
HBNCFIEN_RS04775	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HBNCFIEN_RS04775	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HBNCFIEN_RS04780	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HBNCFIEN_RS04790	COG0305	Participates in initiation and elongation during chromosome replication
HBNCFIEN_RS04800	COG4520	surface antigen
HBNCFIEN_RS04815	COG0626	cystathionine gamma-synthase activity
HBNCFIEN_RS04845	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HBNCFIEN_RS04850	COG1335	isochorismatase
HBNCFIEN_RS04915	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HBNCFIEN_RS04935	COG1994	Peptidase M50
HBNCFIEN_RS04955	COG0531	amino acid
HBNCFIEN_RS04980	COG0686	Belongs to the AlaDH PNT family
HBNCFIEN_RS05030	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HBNCFIEN_RS05040	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HBNCFIEN_RS05050	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HBNCFIEN_RS05055	COG0585	pseudouridine synthase activity
HBNCFIEN_RS05065	COG0457	Tetratricopeptide repeat
HBNCFIEN_RS05065	COG3118	belongs to the thioredoxin family
HBNCFIEN_RS05070	COG2194	sulfuric ester hydrolase activity
HBNCFIEN_RS05080	COG1215	transferase activity, transferring glycosyl groups
HBNCFIEN_RS05090	COG0514	ATP-dependent DNA helicase (RecQ)
HBNCFIEN_RS05100	COG1960	acyl-CoA dehydrogenase activity
HBNCFIEN_RS05105	COG1024	Enoyl-CoA hydratase
HBNCFIEN_RS05110	COG1024	Enoyl-CoA hydratase
HBNCFIEN_RS05165	COG1561	YicC-like family, N-terminal region
HBNCFIEN_RS05180	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HBNCFIEN_RS05235	COG0352	thiamine-phosphate diphosphorylase activity
HBNCFIEN_RS05240	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HBNCFIEN_RS05245	COG1862	Preprotein translocase
HBNCFIEN_RS05250	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HBNCFIEN_RS05255	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HBNCFIEN_RS05265	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HBNCFIEN_RS05280	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HBNCFIEN_RS05295	COG0833	amino acid
HBNCFIEN_RS05385	COG3177	Filamentation induced by cAMP protein fic
HBNCFIEN_RS05400	COG2755	lipolytic protein G-D-S-L family
HBNCFIEN_RS05400	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HBNCFIEN_RS05405	COG2755	lipolytic protein G-D-S-L family
HBNCFIEN_RS05405	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HBNCFIEN_RS05460	COG0367	asparagine synthase
HBNCFIEN_RS05470	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HBNCFIEN_RS05475	COG1846	Transcriptional regulator
HBNCFIEN_RS05495	COG1396	sequence-specific DNA binding
HBNCFIEN_RS05510	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HBNCFIEN_RS05525	COG2354	Protein conserved in bacteria
HBNCFIEN_RS05555	COG1983	PspC domain protein
HBNCFIEN_RS05560	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HBNCFIEN_RS05590	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
HBNCFIEN_RS05600	COG3706	GGDEF domain
HBNCFIEN_RS05635	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HBNCFIEN_RS05640	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HBNCFIEN_RS05660	COG1573	uracil-dna glycosylase
HBNCFIEN_RS05670	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HBNCFIEN_RS05700	COG0723	plastoquinol--plastocyanin reductase activity
HBNCFIEN_RS05700	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HBNCFIEN_RS05710	COG5310	Homospermidine synthase
HBNCFIEN_RS05745	COG0693	protein deglycase activity
HBNCFIEN_RS05785	COG1028	Short-chain dehydrogenase reductase Sdr
HBNCFIEN_RS05800	COG3237	CsbD-like
HBNCFIEN_RS05830	COG1058	Belongs to the CinA family
HBNCFIEN_RS05830	COG1546	Belongs to the CinA family
HBNCFIEN_RS05840	COG0668	transmembrane transport
HBNCFIEN_RS05845	COG3932	Exopolysaccharide synthesis, ExoD
HBNCFIEN_RS05900	COG1793	dna ligase
HBNCFIEN_RS05910	COG0069	glutamate synthase activity
HBNCFIEN_RS05925	COG1796	DNA polymerase
HBNCFIEN_RS05925	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HBNCFIEN_RS05955	COG4251	negative regulation of phosphorylation
HBNCFIEN_RS05955	COG2203	Gaf domain
HBNCFIEN_RS05955	COG5001	Diguanylate cyclase
HBNCFIEN_RS05955	COG3706	GGDEF domain
HBNCFIEN_RS05975	COG2363	Small membrane protein
HBNCFIEN_RS05980	COG0424	maF-like protein
HBNCFIEN_RS05995	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HBNCFIEN_RS06000	COG3706	GGDEF domain
HBNCFIEN_RS06020	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HBNCFIEN_RS06075	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HBNCFIEN_RS06090	COG3220	belongs to the UPF0276 family
HBNCFIEN_RS06100	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
HBNCFIEN_RS06110	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HBNCFIEN_RS06140	COG1472	Belongs to the glycosyl hydrolase 3 family
HBNCFIEN_RS06145	COG2226	methyltransferase
HBNCFIEN_RS06150	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
HBNCFIEN_RS06185	COG2814	Major facilitator Superfamily
HBNCFIEN_RS06220	COG4783	chaperone-mediated protein folding
HBNCFIEN_RS06225	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HBNCFIEN_RS06225	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HBNCFIEN_RS06230	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HBNCFIEN_RS06230	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HBNCFIEN_RS06260	COG0572	uridine kinase
HBNCFIEN_RS06265	COG1524	type I phosphodiesterase nucleotide pyrophosphatase
HBNCFIEN_RS06275	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HBNCFIEN_RS06290	COG0189	ligase activity
HBNCFIEN_RS06295	COG2853	Lipoprotein
HBNCFIEN_RS06310	COG0210	DNA helicase
HBNCFIEN_RS06315	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HBNCFIEN_RS06315	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HBNCFIEN_RS06325	COG0751	glycine-tRNA ligase activity
HBNCFIEN_RS06330	COG0742	ribosomal rna small subunit methyltransferase
HBNCFIEN_RS06345	COG1464	Belongs to the NlpA lipoprotein family
HBNCFIEN_RS06350	COG2011	ABC-type metal ion transport system permease component
HBNCFIEN_RS06360	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HBNCFIEN_RS06380	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HBNCFIEN_RS06390	COG0183	Belongs to the thiolase family
HBNCFIEN_RS06395	COG1960	acyl-CoA dehydrogenase activity
HBNCFIEN_RS06415	COG1132	(ABC) transporter
HBNCFIEN_RS06440	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HBNCFIEN_RS06450	COG0019	diaminopimelate decarboxylase activity
HBNCFIEN_RS06470	COG0489	protein tyrosine kinase activity
HBNCFIEN_RS06480	COG0527	aspartate kinase activity
HBNCFIEN_RS06495	COG0113	porphobilinogen synthase activity
HBNCFIEN_RS06515	COG0174	glutamine synthetase
HBNCFIEN_RS06530	COG0519	Catalyzes the synthesis of GMP from XMP
HBNCFIEN_RS06570	COG4221	oxidoreductase activity
HBNCFIEN_RS06605	COG1987	bacterial-type flagellum assembly
HBNCFIEN_RS06610	COG1684	flagellar biosynthetic protein fliR
HBNCFIEN_RS06640	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HBNCFIEN_RS06685	COG0259	pyridoxamine-phosphate oxidase activity
HBNCFIEN_RS06695	COG1132	(ABC) transporter
HBNCFIEN_RS06750	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
HBNCFIEN_RS06755	COG0217	transcriptional regulatory protein
HBNCFIEN_RS06770	COG0642	Histidine kinase
HBNCFIEN_RS06775	COG0745	RESPONSE REGULATOR receiver
HBNCFIEN_RS06785	COG0741	lytic transglycosylase activity
HBNCFIEN_RS06785	COG1388	LysM domain
HBNCFIEN_RS06805	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HBNCFIEN_RS06825	COG0508	dehydrogenase complex catalyzes the overall conversion of
HBNCFIEN_RS06865	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HBNCFIEN_RS06890	COG1566	PFAM secretion protein HlyD family protein
HBNCFIEN_RS06895	COG1538	Outer membrane efflux protein
HBNCFIEN_RS06900	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HBNCFIEN_RS06925	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HBNCFIEN_RS06930	COG2252	PERMEase
HBNCFIEN_RS06960	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HBNCFIEN_RS06970	COG0564	pseudouridine synthase activity
HBNCFIEN_RS06995	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HBNCFIEN_RS07015	COG0285	dihydrofolate synthase activity
HBNCFIEN_RS07025	COG1286	toxin biosynthetic process
HBNCFIEN_RS07050	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HBNCFIEN_RS07055	COG3243	poly(R)-hydroxyalkanoic acid synthase
HBNCFIEN_RS07065	COG1012	belongs to the aldehyde dehydrogenase family
HBNCFIEN_RS07070	COG1250	3-hydroxyacyl-CoA dehydrogenase
HBNCFIEN_RS07070	COG1024	Enoyl-CoA hydratase
HBNCFIEN_RS07075	COG0183	Belongs to the thiolase family
HBNCFIEN_RS07100	COG0492	ferredoxin-NADP+ reductase activity
HBNCFIEN_RS07105	COG1674	ftsk spoiiie
HBNCFIEN_RS07115	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HBNCFIEN_RS07125	COG3852	Histidine kinase
HBNCFIEN_RS07135	COG1677	Flagellar hook-basal body complex protein FliE
HBNCFIEN_RS07145	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HBNCFIEN_RS07175	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HBNCFIEN_RS07205	COG0542	response to heat
HBNCFIEN_RS07210	COG0616	signal peptide processing
HBNCFIEN_RS07220	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
HBNCFIEN_RS07225	COG1104	cysteine desulfurase activity
HBNCFIEN_RS07235	COG0316	Belongs to the HesB IscA family
HBNCFIEN_RS07245	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
HBNCFIEN_RS07255	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HBNCFIEN_RS07265	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HBNCFIEN_RS07280	COG1438	arginine binding
HBNCFIEN_RS07285	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HBNCFIEN_RS07290	COG0765	amino acid transport
HBNCFIEN_RS07295	COG1126	abc transporter atp-binding protein
HBNCFIEN_RS07305	COG0165	Argininosuccinate lyase
HBNCFIEN_RS07310	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HBNCFIEN_RS07310	COG0512	Glutamine amidotransferase of anthranilate synthase
HBNCFIEN_RS07315	COG0038	chloride channel
HBNCFIEN_RS07335	COG3842	ATPase activity
HBNCFIEN_RS07345	COG2267	carboxylic ester hydrolase activity
HBNCFIEN_RS07350	COG1960	acyl-CoA dehydrogenase activity
HBNCFIEN_RS07365	COG2894	cell division
HBNCFIEN_RS07430	COG0477	Major facilitator Superfamily
HBNCFIEN_RS07495	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HBNCFIEN_RS07505	COG2890	protein-(glutamine-N5) methyltransferase activity
HBNCFIEN_RS07525	COG0745	RESPONSE REGULATOR receiver
HBNCFIEN_RS07535	COG2205	protein histidine kinase activity
HBNCFIEN_RS07575	COG0322	excinuclease ABC activity
HBNCFIEN_RS07675	COG2827	Endonuclease containing a URI domain
HBNCFIEN_RS07695	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HBNCFIEN_RS07745	COG0183	Belongs to the thiolase family
HBNCFIEN_RS07750	COG1024	Enoyl-CoA hydratase
HBNCFIEN_RS07750	COG1250	3-hydroxyacyl-CoA dehydrogenase
HBNCFIEN_RS07755	COG1376	ErfK ybiS ycfS ynhG family protein
HBNCFIEN_RS07765	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HBNCFIEN_RS07805	COG1012	belongs to the aldehyde dehydrogenase family
HBNCFIEN_RS07810	COG2902	Dehydrogenase
HBNCFIEN_RS07830	COG1595	DNA-templated transcription, initiation
HBNCFIEN_RS07845	COG2255	four-way junction helicase activity
HBNCFIEN_RS07850	COG0824	Thioesterase
HBNCFIEN_RS07870	COG0823	Involved in the tonB-independent uptake of proteins
HBNCFIEN_RS07900	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HBNCFIEN_RS07910	COG0494	nUDIX hydrolase
HBNCFIEN_RS07915	COG0318	PFAM AMP-dependent synthetase and ligase
HBNCFIEN_RS07920	COG0850	regulation of cytokinetic process
HBNCFIEN_RS07925	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HBNCFIEN_RS07950	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HBNCFIEN_RS07955	COG3063	Type IV pilus biogenesis stability protein PilW
HBNCFIEN_RS07960	COG1426	Protein conserved in bacteria
HBNCFIEN_RS07995	COG0589	response to stress
HBNCFIEN_RS08000	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HBNCFIEN_RS08005	COG0617	tRNA 3'-terminal CCA addition
HBNCFIEN_RS08010	COG0861	Integral membrane protein TerC family
HBNCFIEN_RS08035	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HBNCFIEN_RS08035	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HBNCFIEN_RS08040	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HBNCFIEN_RS08045	COG0372	Belongs to the citrate synthase family
HBNCFIEN_RS08050	COG2079	MmgE PrpD family protein
HBNCFIEN_RS08085	COG0698	ribose 5-phosphate isomerase
HBNCFIEN_RS08090	COG0531	amino acid
HBNCFIEN_RS08105	COG3706	GGDEF domain
HBNCFIEN_RS08120	COG2271	Major facilitator Superfamily
HBNCFIEN_RS08130	COG0531	amino acid
HBNCFIEN_RS08145	COG0071	Belongs to the small heat shock protein (HSP20) family
HBNCFIEN_RS08155	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HBNCFIEN_RS08170	COG0425	Belongs to the sulfur carrier protein TusA family
HBNCFIEN_RS08170	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HBNCFIEN_RS08195	COG0656	L-ascorbic acid biosynthetic process
HBNCFIEN_RS08205	COG1028	Short-chain dehydrogenase reductase Sdr
HBNCFIEN_RS08215	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
HBNCFIEN_RS08230	COG1011	Hydrolase
HBNCFIEN_RS08235	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HBNCFIEN_RS08285	COG0308	aminopeptidase N
HBNCFIEN_RS08315	COG2373	Large extracellular alpha-helical protein
HBNCFIEN_RS08320	COG4953	penicillin-binding protein 1C
HBNCFIEN_RS08325	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HBNCFIEN_RS08455	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HBNCFIEN_RS08455	COG0456	acetyltransferase
HBNCFIEN_RS08525	COG3264	Mechanosensitive ion channel
HBNCFIEN_RS08525	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
HBNCFIEN_RS08560	COG0300	oxidoreductase activity
HBNCFIEN_RS08575	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HBNCFIEN_RS08580	COG0531	amino acid
HBNCFIEN_RS08600	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
HBNCFIEN_RS08630	COG3138	arginine N-succinyltransferase
HBNCFIEN_RS08690	COG3038	cytochrome b561
HBNCFIEN_RS08710	COG0596	Alpha beta hydrolase
HBNCFIEN_RS08715	COG0156	8-amino-7-oxononanoate synthase activity
HBNCFIEN_RS08730	COG2200	EAL domain
HBNCFIEN_RS08750	COG0494	nUDIX hydrolase
HBNCFIEN_RS08760	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HBNCFIEN_RS08765	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HBNCFIEN_RS08775	COG0436	Aminotransferase
HBNCFIEN_RS08785	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HBNCFIEN_RS08790	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HBNCFIEN_RS08800	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HBNCFIEN_RS08805	COG0508	dehydrogenase complex catalyzes the overall conversion of
HBNCFIEN_RS08825	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HBNCFIEN_RS08830	COG1686	Belongs to the peptidase S11 family
HBNCFIEN_RS08835	COG2921	Belongs to the UPF0250 family
HBNCFIEN_RS08845	COG0586	Pfam SNARE associated Golgi protein
HBNCFIEN_RS08855	COG3034	peptidoglycan biosynthetic process
HBNCFIEN_RS08860	COG1187	pseudouridine synthase activity
HBNCFIEN_RS08865	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HBNCFIEN_RS08870	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HBNCFIEN_RS08875	COG0180	Tryptophanyl-tRNA synthetase
HBNCFIEN_RS08880	COG0009	L-threonylcarbamoyladenylate synthase
HBNCFIEN_RS08885	COG0613	PHP domain protein
HBNCFIEN_RS08890	COG1702	phosphate starvation-inducible protein PhoH
HBNCFIEN_RS08905	COG0745	RESPONSE REGULATOR receiver
HBNCFIEN_RS08910	COG5002	protein histidine kinase activity
HBNCFIEN_RS08920	COG0295	cytidine deaminase activity
HBNCFIEN_RS08925	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HBNCFIEN_RS08930	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HBNCFIEN_RS08940	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HBNCFIEN_RS08970	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HBNCFIEN_RS08985	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HBNCFIEN_RS08995	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HBNCFIEN_RS09005	COG0372	Belongs to the citrate synthase family
HBNCFIEN_RS09010	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HBNCFIEN_RS09020	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HBNCFIEN_RS09115	COG0084	hydrolase, TatD family'
HBNCFIEN_RS09125	COG0470	DNA polymerase III
HBNCFIEN_RS09135	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HBNCFIEN_RS09140	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HBNCFIEN_RS09145	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HBNCFIEN_RS09150	COG1028	Short-chain dehydrogenase reductase Sdr
HBNCFIEN_RS09155	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HBNCFIEN_RS09160	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HBNCFIEN_RS09180	COG0482	sulfurtransferase activity
HBNCFIEN_RS09200	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HBNCFIEN_RS09210	COG2986	histidine ammonia-lyase
HBNCFIEN_RS09225	COG0799	negative regulation of ribosome biogenesis
HBNCFIEN_RS09235	COG0768	penicillin binding
HBNCFIEN_RS09240	COG0772	Belongs to the SEDS family
HBNCFIEN_RS09250	COG0673	inositol 2-dehydrogenase activity
HBNCFIEN_RS09260	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
HBNCFIEN_RS09280	COG2515	1-aminocyclopropane-1-carboxylate deaminase
HBNCFIEN_RS09285	COG3022	response to hydroperoxide
HBNCFIEN_RS09295	COG0174	glutamine synthetase
HBNCFIEN_RS09300	COG1459	type II secretion system
HBNCFIEN_RS09305	COG2165	general secretion pathway protein
HBNCFIEN_RS09325	COG3156	type II secretion system protein K
HBNCFIEN_RS09335	COG0312	modulator of DNA gyrase
HBNCFIEN_RS09345	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HBNCFIEN_RS09345	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HBNCFIEN_RS09370	COG1132	(ABC) transporter
HBNCFIEN_RS09420	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HBNCFIEN_RS09445	COG0513	Belongs to the DEAD box helicase family
HBNCFIEN_RS09470	COG2814	Major facilitator Superfamily
HBNCFIEN_RS09475	COG2814	Major facilitator Superfamily
HBNCFIEN_RS09480	COG4264	IucA IucC family
HBNCFIEN_RS09490	COG4232	protein-disulfide reductase activity
HBNCFIEN_RS09505	COG0531	amino acid
HBNCFIEN_RS09565	COG1705	Flagellar rod assembly protein muramidase FlgJ
HBNCFIEN_RS09565	COG3951	Flagellar rod assembly protein muramidase FlgJ
HBNCFIEN_RS09570	COG1706	bacterial-type flagellum-dependent cell motility
HBNCFIEN_RS09590	COG1749	Flagellar hook protein flgE
HBNCFIEN_RS09595	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HBNCFIEN_RS09600	COG1558	bacterial-type flagellum-dependent cell motility
HBNCFIEN_RS09605	COG1815	bacterial-type flagellum-dependent cell motility
HBNCFIEN_RS09625	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HBNCFIEN_RS09655	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HBNCFIEN_RS09660	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HBNCFIEN_RS09665	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HBNCFIEN_RS09670	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HBNCFIEN_RS09670	COG0131	Imidazoleglycerol-phosphate dehydratase
HBNCFIEN_RS09680	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HBNCFIEN_RS09690	COG0140	phosphoribosyl-ATP diphosphatase activity
HBNCFIEN_RS09690	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HBNCFIEN_RS09695	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HBNCFIEN_RS09705	COG2974	May be involved in recombination
HBNCFIEN_RS09730	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HBNCFIEN_RS09745	COG0776	regulation of translation
HBNCFIEN_RS09750	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HBNCFIEN_RS09810	COG0571	ribonuclease III activity
HBNCFIEN_RS09820	COG0681	Belongs to the peptidase S26 family
HBNCFIEN_RS09830	COG2951	lytic endotransglycosylase activity
HBNCFIEN_RS09850	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HBNCFIEN_RS09910	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HBNCFIEN_RS09920	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HBNCFIEN_RS09930	COG4191	Histidine kinase
HBNCFIEN_RS09950	COG3012	SEC-C Motif Domain Protein
HBNCFIEN_RS09960	COG2850	peptidyl-arginine hydroxylation
HBNCFIEN_RS09975	COG3101	peptidyl-lysine hydroxylation
HBNCFIEN_RS09980	COG2409	Drug exporters of the RND superfamily
HBNCFIEN_RS10010	COG0625	glutathione transferase activity
HBNCFIEN_RS10035	COG0205	6-phosphofructokinase activity
HBNCFIEN_RS10040	COG4969	Belongs to the N-Me-Phe pilin family
HBNCFIEN_RS10045	COG0271	Belongs to the BolA IbaG family
HBNCFIEN_RS10055	COG0531	amino acid
HBNCFIEN_RS10065	COG1214	PFAM Peptidase M22, glycoprotease
HBNCFIEN_RS10070	COG1199	ATP-dependent helicase activity
HBNCFIEN_RS10075	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HBNCFIEN_RS10130	COG1090	epimerase
HBNCFIEN_RS10155	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HBNCFIEN_RS10160	COG3384	dioxygenase
HBNCFIEN_RS10170	COG3220	belongs to the UPF0276 family
HBNCFIEN_RS10220	COG0402	S-adenosylhomocysteine deaminase activity
HBNCFIEN_RS10225	COG0726	polysaccharide deacetylase
HBNCFIEN_RS10230	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HBNCFIEN_RS10270	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HBNCFIEN_RS10275	COG0601	transmembrane transport
HBNCFIEN_RS10285	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HBNCFIEN_RS10310	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HBNCFIEN_RS10320	COG0312	modulator of DNA gyrase
HBNCFIEN_RS10325	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HBNCFIEN_RS10335	COG1013	pyruvate-flavodoxin oxidoreductase activity
HBNCFIEN_RS10340	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HBNCFIEN_RS10340	COG0674	pyruvate-flavodoxin oxidoreductase activity
HBNCFIEN_RS10370	COG0800	Aldolase
HBNCFIEN_RS10380	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HBNCFIEN_RS10390	COG0196	riboflavin kinase activity
HBNCFIEN_RS10395	COG0589	response to stress
HBNCFIEN_RS10400	COG4235	cytochrome complex assembly
HBNCFIEN_RS10415	COG1138	Cytochrome C-type biogenesis protein
HBNCFIEN_RS10450	COG0616	signal peptide processing
HBNCFIEN_RS10485	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HBNCFIEN_RS10495	COG5007	Belongs to the BolA IbaG family
HBNCFIEN_RS10515	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HBNCFIEN_RS10520	COG1127	ABC transporter
HBNCFIEN_RS10530	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HBNCFIEN_RS10545	COG1137	ATPase activity
HBNCFIEN_RS10550	COG0512	Glutamine amidotransferase of anthranilate synthase
HBNCFIEN_RS10600	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
HBNCFIEN_RS10620	COG0542	response to heat
HBNCFIEN_RS10640	COG1187	pseudouridine synthase activity
HBNCFIEN_RS10650	COG1792	Involved in formation and maintenance of cell shape
HBNCFIEN_RS10655	COG1077	Cell shape determining protein MreB Mrl
HBNCFIEN_RS10670	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HBNCFIEN_RS10685	COG0475	glutathione-regulated potassium exporter activity
HBNCFIEN_RS10695	COG0659	secondary active sulfate transmembrane transporter activity
HBNCFIEN_RS10705	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HBNCFIEN_RS10710	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HBNCFIEN_RS10755	COG2223	nitrite transmembrane transporter activity
HBNCFIEN_RS10765	COG1760	l-serine dehydratase
HBNCFIEN_RS10785	COG2091	lysine biosynthetic process via aminoadipic acid
HBNCFIEN_RS10805	COG3104	oligopeptide transport
HBNCFIEN_RS10845	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HBNCFIEN_RS10860	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
HBNCFIEN_RS10865	COG2885	chlorophyll binding
HBNCFIEN_RS10870	COG3218	ABC-type transport auxiliary lipoprotein component
HBNCFIEN_RS10880	COG1127	ABC transporter
HBNCFIEN_RS10885	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HBNCFIEN_RS10930	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HBNCFIEN_RS10945	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HBNCFIEN_RS10960	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HBNCFIEN_RS10985	COG1278	Cold shock
HBNCFIEN_RS10990	COG0724	RNA recognition motif
HBNCFIEN_RS10995	COG0513	Belongs to the DEAD box helicase family
HBNCFIEN_RS11035	COG2198	Histidine kinase
HBNCFIEN_RS11035	COG0643	Histidine kinase
HBNCFIEN_RS11040	COG2201	protein-glutamate methylesterase activity
HBNCFIEN_RS11045	COG0835	chemotaxis
HBNCFIEN_RS11050	COG0840	transmembrane signaling receptor activity
HBNCFIEN_RS11075	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HBNCFIEN_RS11080	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HBNCFIEN_RS11085	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HBNCFIEN_RS11095	COG0598	Magnesium transport protein CorA
HBNCFIEN_RS11100	COG0501	Belongs to the peptidase M48B family
HBNCFIEN_RS11105	COG5507	3-demethylubiquinone-9 3-methyltransferase
HBNCFIEN_RS11125	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HBNCFIEN_RS11175	COG3706	GGDEF domain
HBNCFIEN_RS11180	COG0288	reversible hydration of carbon dioxide
HBNCFIEN_RS11220	COG2132	Multicopper oxidase
HBNCFIEN_RS11230	COG2271	Major facilitator Superfamily
HBNCFIEN_RS11235	COG1522	sequence-specific DNA binding
HBNCFIEN_RS11250	COG0494	nUDIX hydrolase
HBNCFIEN_RS11265	COG1566	PFAM secretion protein HlyD family protein
HBNCFIEN_RS11285	COG4566	intracellular signal transduction
HBNCFIEN_RS11290	COG1028	Short-chain dehydrogenase reductase Sdr
HBNCFIEN_RS11350	COG2217	Heavy metal translocating P-type atpase
HBNCFIEN_RS11350	COG2608	mercury ion transmembrane transporter activity
HBNCFIEN_RS11400	COG3781	membrane
HBNCFIEN_RS11420	COG1960	acyl-CoA dehydrogenase activity
HBNCFIEN_RS11430	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
HBNCFIEN_RS11445	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HBNCFIEN_RS11455	COG0409	Hydrogenase expression formation protein
HBNCFIEN_RS11460	COG0309	Hydrogenase expression formation protein (HypE)
HBNCFIEN_RS11470	COG0543	2 iron, 2 sulfur cluster binding
HBNCFIEN_RS11500	COG1028	Short-chain dehydrogenase reductase Sdr
HBNCFIEN_RS11510	COG1393	Belongs to the ArsC family
HBNCFIEN_RS11530	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HBNCFIEN_RS11535	COG1573	uracil-dna glycosylase
HBNCFIEN_RS11545	COG3475	LICD family
HBNCFIEN_RS11555	COG1132	(ABC) transporter
HBNCFIEN_RS11580	COG1823	symporter activity
HBNCFIEN_RS11585	COG1472	Belongs to the glycosyl hydrolase 3 family
HBNCFIEN_RS11620	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HBNCFIEN_RS11625	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HBNCFIEN_RS11630	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
HBNCFIEN_RS11635	COG2205	protein histidine kinase activity
HBNCFIEN_RS11640	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HBNCFIEN_RS11665	COG1252	NADH dehydrogenase
HBNCFIEN_RS11685	COG0628	permease
HBNCFIEN_RS11705	COG0519	Catalyzes the synthesis of GMP from XMP
HBNCFIEN_RS11715	COG0429	hydrolase of the alpha beta-hydrolase fold
HBNCFIEN_RS11750	COG0427	acetyl-CoA hydrolase
HBNCFIEN_RS11755	COG2301	Belongs to the HpcH HpaI aldolase family
HBNCFIEN_RS11760	COG2030	dehydratase
HBNCFIEN_RS11765	COG1012	belongs to the aldehyde dehydrogenase family
HBNCFIEN_RS11775	COG0784	Response regulator, receiver
HBNCFIEN_RS11775	COG2205	protein histidine kinase activity
HBNCFIEN_RS11795	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HBNCFIEN_RS11805	COG2032	superoxide dismutase activity
HBNCFIEN_RS11815	COG1881	PFAM PEBP family protein
HBNCFIEN_RS11835	COG0494	nUDIX hydrolase
HBNCFIEN_RS11840	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HBNCFIEN_RS11850	COG0505	Belongs to the CarA family
HBNCFIEN_RS11875	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
HBNCFIEN_RS11905	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HBNCFIEN_RS11950	COG1522	sequence-specific DNA binding
HBNCFIEN_RS11985	COG0814	amino acid
HBNCFIEN_RS11990	COG0814	amino acid
HBNCFIEN_RS12010	COG4242	Belongs to the peptidase S51 family
HBNCFIEN_RS12015	COG0189	ligase activity
HBNCFIEN_RS12015	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HBNCFIEN_RS12030	COG3237	CsbD-like
HBNCFIEN_RS12060	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
HBNCFIEN_RS12085	COG1252	NADH dehydrogenase
HBNCFIEN_RS12105	COG0833	amino acid
HBNCFIEN_RS12125	COG0288	reversible hydration of carbon dioxide
HBNCFIEN_RS12135	COG0477	Major facilitator Superfamily
HBNCFIEN_RS12145	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HBNCFIEN_RS12160	COG0281	malic enzyme
HBNCFIEN_RS12170	COG0783	Belongs to the Dps family
HBNCFIEN_RS12175	COG0708	Exodeoxyribonuclease III
HBNCFIEN_RS12180	COG0708	Exodeoxyribonuclease III
HBNCFIEN_RS12205	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HBNCFIEN_RS12220	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HBNCFIEN_RS12235	COG4969	Belongs to the N-Me-Phe pilin family
HBNCFIEN_RS12245	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HBNCFIEN_RS12245	COG2169	Transcriptional regulator
HBNCFIEN_RS12265	COG1959	2 iron, 2 sulfur cluster binding
HBNCFIEN_RS12270	COG3189	MarR family transcriptional regulator
HBNCFIEN_RS12285	COG1271	oxidase subunit
HBNCFIEN_RS12310	COG4178	(ABC) transporter
HBNCFIEN_RS12330	COG1566	PFAM secretion protein HlyD family protein
HBNCFIEN_RS12370	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HBNCFIEN_RS12380	COG0318	PFAM AMP-dependent synthetase and ligase
HBNCFIEN_RS12385	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HBNCFIEN_RS12400	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HBNCFIEN_RS12420	COG2814	Major facilitator Superfamily
HBNCFIEN_RS12445	COG0814	amino acid
HBNCFIEN_RS12450	COG1475	DNA binding
HBNCFIEN_RS12455	COG2027	D-alanyl-D-alanine carboxypeptidase
HBNCFIEN_RS12465	COG1764	response to oxidative stress
HBNCFIEN_RS12475	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HBNCFIEN_RS12480	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HBNCFIEN_RS12530	COG0700	Nucleoside recognition
HBNCFIEN_RS12535	COG2715	membrane protein required for spore maturation
HBNCFIEN_RS12550	COG2927	DNA polymerase III (CHI subunit)
HBNCFIEN_RS12600	COG2197	response regulator
HBNCFIEN_RS12615	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HBNCFIEN_RS12640	COG0012	GTP binding
HBNCFIEN_RS12645	COG0142	geranyltranstransferase activity
HBNCFIEN_RS12690	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HBNCFIEN_RS12695	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HBNCFIEN_RS12735	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HBNCFIEN_RS12755	COG0575	Belongs to the CDS family
HBNCFIEN_RS12770	COG4942	peptidase
HBNCFIEN_RS12775	COG0793	Belongs to the peptidase S41A family
HBNCFIEN_RS12795	COG0330	HflC and HflK could
HBNCFIEN_RS12800	COG0330	HflC and HflK could
HBNCFIEN_RS12810	COG1280	lysine exporter protein (LysE YggA)
HBNCFIEN_RS12835	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HBNCFIEN_RS12850	COG1183	phosphatidylcholine synthase activity
HBNCFIEN_RS12870	COG3588	fructose-bisphosphate aldolase
HBNCFIEN_RS12875	COG3568	Endonuclease Exonuclease Phosphatase
HBNCFIEN_RS12890	COG2814	Major facilitator Superfamily
HBNCFIEN_RS12900	COG0511	ligase activity, forming carbon-carbon bonds
HBNCFIEN_RS12905	COG0439	Biotin carboxylase
HBNCFIEN_RS12925	COG3243	poly(R)-hydroxyalkanoic acid synthase
HBNCFIEN_RS12940	COG4969	Belongs to the N-Me-Phe pilin family
HBNCFIEN_RS12945	COG1459	type II secretion system
HBNCFIEN_RS12950	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HBNCFIEN_RS12960	COG3267	Type II secretory pathway component ExeA
HBNCFIEN_RS12960	COG3409	Peptidoglycan-binding domain 1 protein
HBNCFIEN_RS13015	COG0398	Pfam SNARE associated Golgi protein
HBNCFIEN_RS13030	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HBNCFIEN_RS13035	COG0347	Belongs to the P(II) protein family
HBNCFIEN_RS13040	COG2960	long-chain fatty acid transporting porin activity
HBNCFIEN_RS13045	COG0606	chelatase, subunit chli
HBNCFIEN_RS13060	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HBNCFIEN_RS13075	COG1392	Phosphate transport regulator
HBNCFIEN_RS13080	COG0306	phosphate transporter
HBNCFIEN_RS13090	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HBNCFIEN_RS13110	COG3590	peptidase
HBNCFIEN_RS13120	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HBNCFIEN_RS13145	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HBNCFIEN_RS13150	COG0772	Belongs to the SEDS family
HBNCFIEN_RS13160	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HBNCFIEN_RS13165	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HBNCFIEN_RS13170	COG3115	cell septum assembly
HBNCFIEN_RS13175	COG1196	nuclear chromosome segregation
HBNCFIEN_RS13200	COG1301	dicarboxylic acid transport
HBNCFIEN_RS13205	COG1983	PspC domain protein
HBNCFIEN_RS13210	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HBNCFIEN_RS13215	COG0450	alkyl hydroperoxide reductase
HBNCFIEN_RS13220	COG0583	DNA-binding transcription factor activity
HBNCFIEN_RS13235	COG0745	RESPONSE REGULATOR receiver
HBNCFIEN_RS13240	COG2205	protein histidine kinase activity
HBNCFIEN_RS13330	COG1278	Cold shock
HBNCFIEN_RS13345	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HBNCFIEN_RS13360	COG2814	Major facilitator Superfamily
HBNCFIEN_RS13365	COG0800	Aldolase
HBNCFIEN_RS13370	COG0837	glucose binding
HBNCFIEN_RS13375	COG0129	dihydroxy-acid dehydratase activity
HBNCFIEN_RS13385	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HBNCFIEN_RS13415	COG1612	heme a metabolic process
HBNCFIEN_RS13440	COG3706	GGDEF domain
HBNCFIEN_RS13460	COG0531	amino acid
HBNCFIEN_RS13465	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HBNCFIEN_RS13480	COG0336	Belongs to the RNA methyltransferase TrmD family
HBNCFIEN_RS13490	COG0842	Transport permease protein
HBNCFIEN_RS13490	COG1129	ABC transporter
HBNCFIEN_RS13495	COG1131	(ABC) transporter
HBNCFIEN_RS13570	COG1131	(ABC) transporter
HBNCFIEN_RS13575	COG0842	Transport permease protein
HBNCFIEN_RS13580	COG0501	Belongs to the peptidase M48B family
HBNCFIEN_RS13585	COG1704	LemA family
HBNCFIEN_RS13615	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HBNCFIEN_RS13630	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HBNCFIEN_RS13635	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HBNCFIEN_RS13665	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HBNCFIEN_RS13675	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HBNCFIEN_RS13675	COG0321	lipoyl(octanoyl) transferase activity
HBNCFIEN_RS13685	COG0735	belongs to the Fur family
HBNCFIEN_RS13690	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HBNCFIEN_RS13730	COG1560	Kdo2-lipid A biosynthetic process
HBNCFIEN_RS13740	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HBNCFIEN_RS13745	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HBNCFIEN_RS13755	COG1028	Short-chain dehydrogenase reductase Sdr
HBNCFIEN_RS13760	COG2814	Major facilitator Superfamily
HBNCFIEN_RS13780	COG1051	belongs to the nudix hydrolase family
HBNCFIEN_RS13785	COG0789	Transcriptional regulator
HBNCFIEN_RS13790	COG0629	single-stranded DNA binding
HBNCFIEN_RS13970	COG0222	ribosome binding
HBNCFIEN_RS13995	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HBNCFIEN_RS14055	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HBNCFIEN_RS14060	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HBNCFIEN_RS14075	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HBNCFIEN_RS14110	COG1509	lysine 2,3-aminomutase activity
HBNCFIEN_RS14115	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HBNCFIEN_RS14135	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HBNCFIEN_RS14140	COG0435	Glutathione S-transferase
HBNCFIEN_RS14150	COG2313	pseudouridylate synthase activity
HBNCFIEN_RS14200	COG1131	(ABC) transporter
HBNCFIEN_RS14205	COG0842	Transport permease protein
HBNCFIEN_RS14210	COG1538	Outer membrane efflux protein
HBNCFIEN_RS14215	COG0386	Belongs to the glutathione peroxidase family
HBNCFIEN_RS14250	COG3932	Exopolysaccharide synthesis, ExoD
HBNCFIEN_RS14255	COG0730	response to heat
HBNCFIEN_RS14260	COG0861	Integral membrane protein TerC family
HBNCFIEN_RS14295	COG4191	Histidine kinase
HBNCFIEN_RS14300	COG0281	malic enzyme
HBNCFIEN_RS14305	COG1741	Belongs to the pirin family
HBNCFIEN_RS14390	COG2814	Major facilitator Superfamily
HBNCFIEN_RS14565	COG0028	Belongs to the TPP enzyme family
HBNCFIEN_RS14570	COG1012	belongs to the aldehyde dehydrogenase family
HBNCFIEN_RS14575	COG0505	Belongs to the CarA family
HBNCFIEN_RS14585	COG0546	phosphoglycolate phosphatase activity
HBNCFIEN_RS14610	COG2066	Belongs to the glutaminase family
HBNCFIEN_RS14625	COG0318	PFAM AMP-dependent synthetase and ligase
HBNCFIEN_RS14630	COG0156	8-amino-7-oxononanoate synthase activity
HBNCFIEN_RS14635	COG1253	flavin adenine dinucleotide binding
HBNCFIEN_RS14645	COG3961	Belongs to the TPP enzyme family
HBNCFIEN_RS14675	COG1028	Short-chain dehydrogenase reductase Sdr
HBNCFIEN_RS14700	COG4251	negative regulation of phosphorylation
HBNCFIEN_RS14730	COG1082	Xylose isomerase domain protein TIM barrel
HBNCFIEN_RS14740	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HBNCFIEN_RS14745	COG0673	inositol 2-dehydrogenase activity
HBNCFIEN_RS14750	COG2814	Major facilitator Superfamily
HBNCFIEN_RS14775	COG0477	Major facilitator Superfamily
HBNCFIEN_RS14790	COG0735	belongs to the Fur family
HBNCFIEN_RS14795	COG2217	Heavy metal translocating P-type atpase
HBNCFIEN_RS14820	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HBNCFIEN_RS14825	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HBNCFIEN_RS14930	COG1393	Belongs to the ArsC family
HBNCFIEN_RS14950	COG0300	oxidoreductase activity
HBNCFIEN_RS15005	COG4948	Mandelate Racemase Muconate Lactonizing
HBNCFIEN_RS15055	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HBNCFIEN_RS15070	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HBNCFIEN_RS15170	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HBNCFIEN_RS15195	COG2274	protein secretion by the type I secretion system
HBNCFIEN_RS15195	COG3271	cysteine-type peptidase activity
HBNCFIEN_RS15200	COG0583	DNA-binding transcription factor activity
HBNCFIEN_RS15205	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HBNCFIEN_RS15210	COG3002	Belongs to the UPF0753 family
HBNCFIEN_RS15225	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HBNCFIEN_RS15235	COG1028	Short-chain dehydrogenase reductase Sdr
HBNCFIEN_RS15245	COG1271	oxidase subunit
HBNCFIEN_RS15250	COG1294	oxidase, subunit
HBNCFIEN_RS15290	COG1704	LemA family
HBNCFIEN_RS15315	COG4628	conserved protein (DUF2132)
HBNCFIEN_RS15330	COG0235	Class ii aldolase
HBNCFIEN_RS15370	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HBNCFIEN_RS15395	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HBNCFIEN_RS15410	COG3451	type IV secretory pathway VirB4
HBNCFIEN_RS15515	COG0582	viral genome integration into host DNA
HBNCFIEN_RS15530	COG0339	signal peptide processing
HBNCFIEN_RS15545	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HBNCFIEN_RS15555	COG0469	pyruvate kinase activity
HBNCFIEN_RS15570	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
HBNCFIEN_RS15605	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HBNCFIEN_RS15610	COG1215	transferase activity, transferring glycosyl groups
HBNCFIEN_RS15640	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HBNCFIEN_RS15645	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HBNCFIEN_RS15650	COG0047	phosphoribosylformylglycinamidine synthase activity
HBNCFIEN_RS15665	COG0151	Belongs to the GarS family
HBNCFIEN_RS15670	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HBNCFIEN_RS15690	COG2863	cytochrome
HBNCFIEN_RS15695	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HBNCFIEN_RS15705	COG1116	anion transmembrane transporter activity
HBNCFIEN_RS15750	COG0835	chemotaxis
HBNCFIEN_RS15755	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HBNCFIEN_RS15765	COG0840	transmembrane signaling receptor activity
HBNCFIEN_RS15770	COG0643	Histidine kinase
HBNCFIEN_RS15770	COG2198	Histidine kinase
HBNCFIEN_RS15775	COG2201	protein-glutamate methylesterase activity
HBNCFIEN_RS15785	COG1363	Peptidase, m42
HBNCFIEN_RS15790	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HBNCFIEN_RS15795	COG0588	phosphoglycerate mutase activity
HBNCFIEN_RS15805	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HBNCFIEN_RS15840	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HBNCFIEN_RS15860	COG2197	response regulator
HBNCFIEN_RS15870	COG4251	negative regulation of phosphorylation
HBNCFIEN_RS15880	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HBNCFIEN_RS15900	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HBNCFIEN_RS15905	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HBNCFIEN_RS15910	COG0557	exoribonuclease II activity
HBNCFIEN_RS15930	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HBNCFIEN_RS15980	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HBNCFIEN_RS15985	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HBNCFIEN_RS15990	COG0006	proline dipeptidase activity
HBNCFIEN_RS15995	COG3079	Belongs to the UPF0149 family
HBNCFIEN_RS16005	COG0069	glutamate synthase activity
HBNCFIEN_RS16030	COG0556	nucleotide-excision repair
HBNCFIEN_RS16035	COG0436	Aminotransferase
HBNCFIEN_RS16065	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HBNCFIEN_RS16100	COG1396	sequence-specific DNA binding
HBNCFIEN_RS16105	COG3550	peptidyl-serine autophosphorylation
HBNCFIEN_RS16130	COG2267	carboxylic ester hydrolase activity
HBNCFIEN_RS16175	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HBNCFIEN_RS16180	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HBNCFIEN_RS16195	COG0625	glutathione transferase activity
HBNCFIEN_RS16205	COG0183	Belongs to the thiolase family
HBNCFIEN_RS16240	COG1090	epimerase
HBNCFIEN_RS16250	COG0688	phosphatidylethanolamine metabolic process
HBNCFIEN_RS16280	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HBNCFIEN_RS16285	COG1538	Outer membrane efflux protein
HBNCFIEN_RS16335	COG0356	it plays a direct role in the translocation of protons across the membrane
HBNCFIEN_RS16350	COG2823	Periplasmic or secreted lipoprotein
HBNCFIEN_RS16355	COG2823	Periplasmic or secreted lipoprotein
HBNCFIEN_RS16360	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HBNCFIEN_RS16370	COG3107	peptidoglycan biosynthetic process
HBNCFIEN_RS16375	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HBNCFIEN_RS16390	COG0706	membrane insertase activity
HBNCFIEN_RS16465	COG1476	TRANSCRIPTIONal
HBNCFIEN_RS16470	COG0187	DNA topoisomerase II activity
HBNCFIEN_RS16475	COG3041	Addiction module toxin RelE StbE family
HBNCFIEN_RS16485	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HBNCFIEN_RS16500	COG2337	Toxic component of a toxin-antitoxin (TA) module
HBNCFIEN_RS16530	COG0071	Belongs to the small heat shock protein (HSP20) family
HBNCFIEN_RS16545	COG2801	Transposase and inactivated derivatives
HBNCFIEN_RS16560	COG0842	Transport permease protein
HBNCFIEN_RS16565	COG1129	ABC transporter
HBNCFIEN_RS16565	COG0842	Transport permease protein
HBNCFIEN_RS16570	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HBNCFIEN_RS16580	COG0530	calcium, potassium:sodium antiporter activity
HBNCFIEN_RS16600	COG2814	Major facilitator Superfamily
HBNCFIEN_RS16655	COG1028	Short-chain dehydrogenase reductase Sdr
HBNCFIEN_RS16695	COG1132	(ABC) transporter
HBNCFIEN_RS16705	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HBNCFIEN_RS16705	COG0456	acetyltransferase
HBNCFIEN_RS16725	COG0789	Transcriptional regulator
HBNCFIEN_RS16760	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HBNCFIEN_RS16765	COG4983	Phage plasmid primase, P4 family domain protein
HBNCFIEN_RS16790	COG0519	Catalyzes the synthesis of GMP from XMP
HBNCFIEN_RS16815	COG1181	Belongs to the D-alanine--D-alanine ligase family
HBNCFIEN_RS16815	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HBNCFIEN_RS16820	COG0745	RESPONSE REGULATOR receiver
HBNCFIEN_RS16830	COG2205	protein histidine kinase activity
HBNCFIEN_RS16855	COG2378	regulation of single-species biofilm formation
HBNCFIEN_RS16865	COG1673	EVE domain
HBNCFIEN_RS16880	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HBNCFIEN_RS16925	COG0456	acetyltransferase
HBNCFIEN_RS16945	COG1619	proteins homologs of microcin C7 resistance protein MccF
HBNCFIEN_RS16970	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HBNCFIEN_RS16985	COG1396	sequence-specific DNA binding
HBNCFIEN_RS16990	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HBNCFIEN_RS17010	COG2137	regulation of response to DNA damage stimulus
HBNCFIEN_RS17015	COG4974	Belongs to the 'phage' integrase family
HBNCFIEN_RS17025	COG1475	DNA binding
HBNCFIEN_RS17040	COG1475	DNA binding
HBNCFIEN_RS17050	COG0745	RESPONSE REGULATOR receiver
HBNCFIEN_RS17060	COG3290	protein histidine kinase activity
HBNCFIEN_RS17095	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HBNCFIEN_RS17225	COG2137	regulation of response to DNA damage stimulus
HBNCFIEN_RS17230	COG4566	intracellular signal transduction
HBNCFIEN_RS17245	COG2323	membrane
HBNCFIEN_RS17255	COG1950	PFAM Membrane protein of
HBNCFIEN_RS17350	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HBNCFIEN_RS17395	COG4974	Belongs to the 'phage' integrase family
HBNCFIEN_RS17545	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HBNCFIEN_RS17560	COG2226	methyltransferase
HBNCFIEN_RS17575	COG1192	Involved in chromosome partitioning
HBNCFIEN_RS17600	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair