locus-tag	class	description
A0130_RS00010	COG0745	RESPONSE REGULATOR receiver
A0130_RS00015	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
A0130_RS00025	COG0745	RESPONSE REGULATOR receiver
A0130_RS00030	COG2202	Pas domain
A0130_RS00030	COG2205	protein histidine kinase activity
A0130_RS00035	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A0130_RS00045	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A0130_RS00090	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
A0130_RS00110	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
A0130_RS00115	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
A0130_RS00120	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
A0130_RS00125	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
A0130_RS00135	COG0586	Pfam SNARE associated Golgi protein
A0130_RS00145	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A0130_RS00155	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
A0130_RS00160	COG2884	Cell division ATP-binding protein ftsE
A0130_RS00165	COG2177	Part of the ABC transporter FtsEX involved in
A0130_RS00170	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
A0130_RS00225	COG2814	Major facilitator Superfamily
A0130_RS00245	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A0130_RS00250	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
A0130_RS00255	COG2205	protein histidine kinase activity
A0130_RS00260	COG1028	Short-chain dehydrogenase reductase Sdr
A0130_RS00260	COG0604	alcohol dehydrogenase
A0130_RS00260	COG3321	synthase
A0130_RS00270	COG4152	abc transporter atp-binding protein
A0130_RS00315	COG4941	Belongs to the sigma-70 factor family
A0130_RS00320	COG3795	YCII-related domain
A0130_RS00325	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
A0130_RS00335	COG0395	ABC-type sugar transport system, permease component
A0130_RS00340	COG1175	transmembrane transport
A0130_RS00370	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
A0130_RS00375	COG3387	PFAM Glycoside hydrolase 15-related
A0130_RS00380	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
A0130_RS00405	COG2409	Drug exporters of the RND superfamily
A0130_RS00410	COG1309	transcriptional regulator
A0130_RS00430	COG0129	dihydroxy-acid dehydratase activity
A0130_RS00440	COG0440	acetolactate synthase activity
A0130_RS00445	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
A0130_RS00480	COG0477	Major facilitator Superfamily
A0130_RS00485	COG0473	3-isopropylmalate dehydrogenase activity
A0130_RS00490	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A0130_RS00500	COG0179	Fumarylacetoacetate (FAA) hydrolase
A0130_RS00505	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A0130_RS00510	COG0492	ferredoxin-NADP+ reductase activity
A0130_RS00540	COG0346	lactoylglutathione lyase activity
A0130_RS00590	COG3971	2-oxopent-4-enoate hydratase activity
A0130_RS00625	COG0667	Aldo Keto reductase
A0130_RS00630	COG0477	Major facilitator Superfamily
A0130_RS00670	COG0765	amino acid transport
A0130_RS00675	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A0130_RS00685	COG0697	spore germination
A0130_RS00690	COG2837	iron assimilation
A0130_RS00695	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A0130_RS00715	COG0415	Belongs to the DNA photolyase family
A0130_RS00725	COG2217	Heavy metal translocating P-type atpase
A0130_RS00745	COG3321	synthase
A0130_RS00745	COG0604	alcohol dehydrogenase
A0130_RS00755	COG1309	transcriptional regulator
A0130_RS00765	COG4249	Peptidase C14 caspase catalytic subunit p20
A0130_RS00775	COG0631	protein serine/threonine phosphatase activity
A0130_RS00805	COG0714	Associated with various cellular activities
A0130_RS00825	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
A0130_RS00830	COG0066	3-isopropylmalate dehydratase activity
A0130_RS00845	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
A0130_RS00850	COG1181	Belongs to the D-alanine--D-alanine ligase family
A0130_RS00875	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
A0130_RS00890	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
A0130_RS00895	COG0714	Associated with various cellular activities
A0130_RS00915	COG0333	Belongs to the bacterial ribosomal protein bL32 family
A0130_RS00920	COG0571	ribonuclease III activity
A0130_RS00925	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
A0130_RS00935	COG0683	leucine binding
A0130_RS00985	COG0552	protein localization to endoplasmic reticulum
A0130_RS00995	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A0130_RS01015	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
A0130_RS01020	COG0228	four-way junction DNA binding
A0130_RS01025	COG1837	Belongs to the UPF0109 family
A0130_RS01030	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
A0130_RS01040	COG2271	Major facilitator Superfamily
A0130_RS01045	COG0336	Belongs to the RNA methyltransferase TrmD family
A0130_RS01060	COG0335	large ribosomal subunit rRNA binding
A0130_RS01065	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
A0130_RS01075	COG1881	PFAM PEBP family protein
A0130_RS01080	COG0792	nuclease activity
A0130_RS01095	COG4974	Belongs to the 'phage' integrase family
A0130_RS01110	COG0052	Belongs to the universal ribosomal protein uS2 family
A0130_RS01115	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
A0130_RS01120	COG0528	UMP kinase activity
A0130_RS01125	COG0233	cytoplasmic translational termination
A0130_RS01180	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
A0130_RS01185	COG0366	Alpha amylase catalytic
A0130_RS01200	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
A0130_RS01215	COG0482	sulfurtransferase activity
A0130_RS01240	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A0130_RS01245	COG0154	amidase activity
A0130_RS01250	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A0130_RS01270	COG0318	PFAM AMP-dependent synthetase and ligase
A0130_RS01275	COG0702	epimerase
A0130_RS01300	COG0667	Aldo Keto reductase
A0130_RS01315	COG4721	ABC-type cobalt transport system, permease component
A0130_RS01320	COG1122	ATPase activity
A0130_RS01355	COG2211	Major facilitator Superfamily
A0130_RS01375	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
A0130_RS01395	COG0583	DNA-binding transcription factor activity
A0130_RS01400	COG0475	glutathione-regulated potassium exporter activity
A0130_RS01405	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
A0130_RS01415	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A0130_RS01440	COG0723	plastoquinol--plastocyanin reductase activity
A0130_RS01455	COG1946	Acyl-CoA thioesterase
A0130_RS01475	COG0668	transmembrane transport
A0130_RS01485	COG4585	Histidine kinase
A0130_RS01495	COG1131	(ABC) transporter
A0130_RS01505	COG0698	ribose 5-phosphate isomerase
A0130_RS01520	COG1574	metal-dependent hydrolase with the TIM-barrel fold
A0130_RS01530	COG0783	Belongs to the Dps family
A0130_RS01540	COG2197	response regulator
A0130_RS01565	COG0544	peptidyl-prolyl cis-trans isomerase activity
A0130_RS01575	COG0740	serine-type endopeptidase activity
A0130_RS01580	COG0740	serine-type endopeptidase activity
A0130_RS01585	COG1129	ABC transporter
A0130_RS01590	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
A0130_RS01600	COG0339	signal peptide processing
A0130_RS01635	COG0525	valine-tRNA ligase activity
A0130_RS01640	COG0477	Major facilitator Superfamily
A0130_RS01645	COG1309	transcriptional regulator
A0130_RS01650	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
A0130_RS01665	COG0105	UTP biosynthetic process
A0130_RS01675	COG1530	ribonuclease E activity
A0130_RS01685	COG0261	This protein binds to 23S rRNA in the presence of protein L20
A0130_RS01690	COG0211	Belongs to the bacterial ribosomal protein bL27 family
A0130_RS01695	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A0130_RS01700	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
A0130_RS01705	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
A0130_RS01715	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
A0130_RS01725	COG0799	negative regulation of ribosome biogenesis
A0130_RS01745	COG1690	Belongs to the RtcB family
A0130_RS01755	COG2197	response regulator
A0130_RS01770	COG0596	Alpha beta hydrolase
A0130_RS01775	COG1316	TRANSCRIPTIONal
A0130_RS01800	COG1472	Belongs to the glycosyl hydrolase 3 family
A0130_RS01810	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A0130_RS01815	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A0130_RS01825	COG1012	belongs to the aldehyde dehydrogenase family
A0130_RS01830	COG0531	amino acid
A0130_RS01840	COG1960	acyl-CoA dehydrogenase activity
A0130_RS01860	COG0631	protein serine/threonine phosphatase activity
A0130_RS01875	COG0714	Associated with various cellular activities
A0130_RS01905	COG3842	ATPase activity
A0130_RS01910	COG1176	ABC-type spermidine putrescine transport system, permease component I
A0130_RS01925	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A0130_RS01945	COG0318	PFAM AMP-dependent synthetase and ligase
A0130_RS01945	COG0204	Acyl-transferase
A0130_RS01960	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A0130_RS01965	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
A0130_RS01970	COG0750	zinc metalloprotease
A0130_RS01975	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
A0130_RS01985	COG0442	prolyl-tRNA aminoacylation
A0130_RS02000	COG0587	DNA-directed DNA polymerase activity
A0130_RS02060	COG1968	undecaprenyl-diphosphatase activity
A0130_RS02100	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A0130_RS02105	COG0805	protein transport
A0130_RS02110	COG4581	dead DEAH box helicase
A0130_RS02140	COG1028	Short-chain dehydrogenase reductase Sdr
A0130_RS02145	COG1506	peptidase
A0130_RS02145	COG4946	Tricorn protease homolog
A0130_RS02145	COG0823	Involved in the tonB-independent uptake of proteins
A0130_RS02225	COG0257	Belongs to the bacterial ribosomal protein bL36 family
A0130_RS02230	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A0130_RS02240	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A0130_RS02245	COG1309	transcriptional regulator
A0130_RS02300	COG2226	methyltransferase
A0130_RS02305	COG4251	negative regulation of phosphorylation
A0130_RS02355	COG2211	Major facilitator Superfamily
A0130_RS02360	COG1309	transcriptional regulator
A0130_RS02380	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
A0130_RS02395	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A0130_RS02400	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A0130_RS02405	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A0130_RS02505	COG4585	Histidine kinase
A0130_RS02705	COG2197	response regulator
A0130_RS02710	COG4585	Histidine kinase
A0130_RS02750	COG0438	transferase activity, transferring glycosyl groups
A0130_RS02755	COG0697	spore germination
A0130_RS02760	COG0242	peptide deformylase activity
A0130_RS02780	COG4585	Histidine kinase
A0130_RS02785	COG2197	response regulator
A0130_RS02800	COG4608	Belongs to the ABC transporter superfamily
A0130_RS02815	COG0601	transmembrane transport
A0130_RS02825	COG0358	DNA primase activity
A0130_RS02845	COG0442	prolyl-tRNA aminoacylation
A0130_RS02860	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
A0130_RS02865	COG1381	Involved in DNA repair and RecF pathway recombination
A0130_RS02870	COG2860	membrane
A0130_RS02875	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A0130_RS02880	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
A0130_RS02895	COG1136	(ABC) transporter
A0130_RS02905	COG2197	response regulator
A0130_RS02910	COG4585	Histidine kinase
A0130_RS02915	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
A0130_RS02925	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
A0130_RS02935	COG0537	adenosine 5'-monophosphoramidase activity
A0130_RS02945	COG0484	heat shock protein binding
A0130_RS02950	COG1420	regulation of RNA biosynthetic process
A0130_RS02970	COG4762	Protein conserved in bacteria
A0130_RS02985	COG0481	GTPase activity
A0130_RS02995	COG1090	epimerase
A0130_RS03000	COG0268	Binds directly to 16S ribosomal RNA
A0130_RS03010	COG1555	photosystem II stabilization
A0130_RS03010	COG1596	polysaccharide export
A0130_RS03025	COG0495	leucyl-tRNA aminoacylation
A0130_RS03045	COG4988	ABC transporter
A0130_RS03050	COG1294	oxidase, subunit
A0130_RS03055	COG1271	oxidase subunit
A0130_RS03080	COG1174	glycine betaine transport
A0130_RS03085	COG1174	glycine betaine transport
A0130_RS03140	COG0406	alpha-ribazole phosphatase activity
A0130_RS03155	COG0366	Alpha amylase catalytic
A0130_RS03170	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
A0130_RS03215	COG0254	rRNA binding
A0130_RS03220	COG1119	ATPase activity
A0130_RS03225	COG0297	glycogen (starch) synthase activity
A0130_RS03230	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
A0130_RS03235	COG0560	Phosphoserine phosphatase
A0130_RS03235	COG3830	Belongs to the UPF0237 family
A0130_RS03240	COG1028	Short-chain dehydrogenase reductase Sdr
A0130_RS03265	COG0488	(ABC) transporter
A0130_RS03270	COG2151	metal-sulfur cluster biosynthetic enzyme
A0130_RS03295	COG1612	heme a metabolic process
A0130_RS03305	COG0109	protoheme IX farnesyltransferase activity
A0130_RS03315	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
A0130_RS03320	COG0166	Belongs to the GPI family
A0130_RS03335	COG0363	glucosamine-6-phosphate deaminase activity
A0130_RS03350	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A0130_RS03355	COG0149	triose-phosphate isomerase activity
A0130_RS03360	COG0126	phosphoglycerate kinase activity
A0130_RS03375	COG1481	regulation of sporulation
A0130_RS03380	COG1660	Displays ATPase and GTPase activities
A0130_RS03385	COG0322	excinuclease ABC activity
A0130_RS03405	COG0714	Associated with various cellular activities
A0130_RS03420	COG0556	nucleotide-excision repair
A0130_RS03425	COG0237	dephospho-CoA kinase activity
A0130_RS03430	COG0539	negative regulation of cytoplasmic translation
A0130_RS03455	COG2050	protein possibly involved in aromatic compounds catabolism
A0130_RS03475	COG3118	belongs to the thioredoxin family
A0130_RS03480	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A0130_RS03485	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A0130_RS03510	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
A0130_RS03520	COG5006	permease, DMT superfamily
A0130_RS03530	COG1131	(ABC) transporter
A0130_RS03535	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
A0130_RS03540	COG0469	pyruvate kinase activity
A0130_RS03550	COG0069	glutamate synthase activity
A0130_RS03550	COG0070	glutamate synthase
A0130_RS03550	COG0067	glutamate synthase
A0130_RS03555	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
A0130_RS03560	COG0159	tryptophan synthase activity
A0130_RS03565	COG0133	tryptophan synthase activity
A0130_RS03570	COG0134	indole-3-glycerol-phosphate synthase activity
A0130_RS03590	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
A0130_RS03595	COG0107	imidazoleglycerol-phosphate synthase activity
A0130_RS03600	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
A0130_RS03605	COG0140	phosphoribosyl-ATP diphosphatase activity
A0130_RS03610	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
A0130_RS03620	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
A0130_RS03630	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
A0130_RS03640	COG1758	RNA polymerase activity
A0130_RS03645	COG0194	GDP metabolic process
A0130_RS03650	COG0284	orotidine-5'-phosphate decarboxylase activity
A0130_RS03655	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
A0130_RS03660	COG0505	Belongs to the CarA family
A0130_RS03670	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A0130_RS03675	COG0540	Belongs to the ATCase OTCase family
A0130_RS03680	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
A0130_RS03690	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A0130_RS03695	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
A0130_RS03700	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
A0130_RS03710	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
A0130_RS03715	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
A0130_RS03725	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A0130_RS03735	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
A0130_RS03740	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A0130_RS03755	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
A0130_RS03770	COG1196	nuclear chromosome segregation
A0130_RS03780	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A0130_RS03790	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A0130_RS03795	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A0130_RS03805	COG2255	four-way junction helicase activity
A0130_RS03810	COG0632	four-way junction helicase activity
A0130_RS03815	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
A0130_RS03820	COG0217	transcriptional regulatory protein
A0130_RS03830	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
A0130_RS03840	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
A0130_RS03850	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A0130_RS03960	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
A0130_RS03965	COG0183	Belongs to the thiolase family
A0130_RS03970	COG1024	Enoyl-CoA hydratase
A0130_RS03970	COG1250	3-hydroxyacyl-CoA dehydrogenase
A0130_RS03975	COG0667	Aldo Keto reductase
A0130_RS03980	COG0789	Transcriptional regulator
A0130_RS03990	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
A0130_RS04000	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
A0130_RS04020	COG0756	dUTP diphosphatase activity
A0130_RS04050	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A0130_RS04055	COG0187	DNA topoisomerase II activity
A0130_RS04065	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A0130_RS04070	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A0130_RS04085	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A0130_RS04100	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
A0130_RS04105	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A0130_RS04110	COG0508	dehydrogenase complex catalyzes the overall conversion of
A0130_RS04120	COG0321	lipoyl(octanoyl) transferase activity
A0130_RS04125	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
A0130_RS04140	COG0174	glutamine synthetase
A0130_RS04150	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
A0130_RS04155	COG0174	glutamine synthetase
A0130_RS04170	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
A0130_RS04220	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
A0130_RS04235	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A0130_RS04250	COG1461	Dihydroxyacetone kinase
A0130_RS04255	COG2376	Dihydroxyacetone kinase
A0130_RS04260	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A0130_RS04265	COG1845	cytochrome c oxidase, subunit III
A0130_RS04270	COG2010	Cytochrome c
A0130_RS04275	COG0723	plastoquinol--plastocyanin reductase activity
A0130_RS04280	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
A0130_RS04295	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
A0130_RS04300	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
A0130_RS04320	COG0328	RNA-DNA hybrid ribonuclease activity
A0130_RS04325	COG0167	dihydroorotate dehydrogenase activity
A0130_RS04330	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
A0130_RS04335	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
A0130_RS04340	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A0130_RS04345	COG0587	DNA-directed DNA polymerase activity
A0130_RS04355	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
A0130_RS04370	COG1799	cell septum assembly
A0130_RS04380	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
A0130_RS04385	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
A0130_RS04390	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A0130_RS04395	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A0130_RS04405	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
A0130_RS04410	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A0130_RS04420	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A0130_RS04425	COG0768	penicillin binding
A0130_RS04435	COG0275	rRNA processing
A0130_RS04440	COG2001	Belongs to the MraZ family
A0130_RS04450	COG0142	geranyltranstransferase activity
A0130_RS04465	COG2815	serine threonine protein kinase
A0130_RS04465	COG0515	serine threonine protein kinase
A0130_RS04470	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
A0130_RS04475	COG0204	Acyl-transferase
A0130_RS04480	COG1940	carbohydrate kinase activity
A0130_RS04485	COG1022	Amp-dependent synthetase and ligase
A0130_RS04495	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
A0130_RS04515	COG1192	Involved in chromosome partitioning
A0130_RS04530	COG1716	ATPase activity
A0130_RS04600	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
A0130_RS04610	COG0142	geranyltranstransferase activity
A0130_RS04620	COG0702	epimerase
A0130_RS04630	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A0130_RS04645	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
A0130_RS04665	COG2814	Major facilitator Superfamily
A0130_RS04675	COG1597	lipid kinase activity
A0130_RS04680	COG0372	Belongs to the citrate synthase family
A0130_RS04690	COG2011	ABC-type metal ion transport system permease component
A0130_RS04695	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A0130_RS04700	COG1464	Belongs to the NlpA lipoprotein family
A0130_RS04750	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
A0130_RS04755	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
A0130_RS04760	COG0131	Imidazoleglycerol-phosphate dehydratase
A0130_RS04765	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A0130_RS04770	COG1388	LysM domain
A0130_RS04775	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
A0130_RS04790	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
A0130_RS04795	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A0130_RS04800	COG2813	Specifically methylates the guanine in position
A0130_RS04805	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
A0130_RS04810	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
A0130_RS04815	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A0130_RS04820	COG2137	regulation of response to DNA damage stimulus
A0130_RS04825	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
A0130_RS04840	COG1058	Belongs to the CinA family
A0130_RS04840	COG1546	Belongs to the CinA family
A0130_RS04850	COG1674	ftsk spoiiie
A0130_RS04860	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
A0130_RS04865	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A0130_RS04880	COG1764	response to oxidative stress
A0130_RS04895	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
A0130_RS04910	COG0612	Peptidase, M16
A0130_RS04920	COG0667	Aldo Keto reductase
A0130_RS04945	COG1960	acyl-CoA dehydrogenase activity
A0130_RS04955	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A0130_RS04960	COG1309	transcriptional regulator
A0130_RS04990	COG0672	)-iron permease
A0130_RS05015	COG1217	gtp-binding protein TYPA
A0130_RS05040	COG0747	negative chemotaxis
A0130_RS05050	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A0130_RS05050	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A0130_RS05055	COG0509	glycine decarboxylation via glycine cleavage system
A0130_RS05060	COG0404	The glycine cleavage system catalyzes the degradation of glycine
A0130_RS05070	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
A0130_RS05075	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
A0130_RS05085	COG1104	cysteine desulfurase activity
A0130_RS05090	COG2814	Major facilitator Superfamily
A0130_RS05100	COG1397	ADP-ribosylglycohydrolase
A0130_RS05115	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
A0130_RS05135	COG0395	ABC-type sugar transport system, permease component
A0130_RS05140	COG1175	transmembrane transport
A0130_RS05150	COG1609	Transcriptional regulator
A0130_RS05155	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A0130_RS05170	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A0130_RS05180	COG3321	synthase
A0130_RS05180	COG0604	alcohol dehydrogenase
A0130_RS05180	COG1028	Short-chain dehydrogenase reductase Sdr
A0130_RS05200	COG0477	Major facilitator Superfamily
A0130_RS05205	COG1285	pathogenesis
A0130_RS05255	COG0012	GTP binding
A0130_RS05270	COG1322	Protein conserved in bacteria
A0130_RS05285	COG0477	Major facilitator Superfamily
A0130_RS05290	COG2186	Transcriptional regulator
A0130_RS05300	COG0191	fructose-bisphosphate aldolase activity
A0130_RS05310	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
A0130_RS05315	COG1570	exodeoxyribonuclease VII activity
A0130_RS05320	COG1722	exodeoxyribonuclease VII activity
A0130_RS05330	COG0288	reversible hydration of carbon dioxide
A0130_RS05335	COG0114	fumarate hydratase activity
A0130_RS05350	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
A0130_RS05365	COG1280	lysine exporter protein (LysE YggA)
A0130_RS05370	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A0130_RS05385	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A0130_RS05400	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
A0130_RS05405	COG4208	sulfate ABC transporter
A0130_RS05420	COG3214	Protein conserved in bacteria
A0130_RS05440	COG1309	transcriptional regulator
A0130_RS05445	COG1704	LemA family
A0130_RS05480	COG3012	SEC-C Motif Domain Protein
A0130_RS05520	COG0148	phosphopyruvate hydratase activity
A0130_RS05525	COG0124	histidyl-tRNA synthetase
A0130_RS05535	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A0130_RS05540	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A0130_RS05545	COG1120	ATPase activity
A0130_RS05555	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A0130_RS05580	COG0193	aminoacyl-tRNA hydrolase activity
A0130_RS05585	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
A0130_RS05600	COG3265	gluconokinase activity
A0130_RS05605	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
A0130_RS05625	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
A0130_RS05630	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
A0130_RS05640	COG1846	Transcriptional regulator
A0130_RS05645	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
A0130_RS05650	COG1960	acyl-CoA dehydrogenase activity
A0130_RS05655	COG0488	(ABC) transporter
A0130_RS05665	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
A0130_RS05670	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A0130_RS05675	COG0084	hydrolase, TatD family'
A0130_RS05680	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A0130_RS05705	COG2855	membrane
A0130_RS05710	COG2076	Multidrug Resistance protein
A0130_RS05720	COG1832	CoA-binding protein
A0130_RS05765	COG0386	Belongs to the glutathione peroxidase family
A0130_RS05775	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
A0130_RS05780	COG2197	response regulator
A0130_RS05800	COG0667	Aldo Keto reductase
A0130_RS05815	COG1254	Belongs to the acylphosphatase family
A0130_RS05835	COG1331	Highly conserved protein containing a thioredoxin domain
A0130_RS05850	COG0318	PFAM AMP-dependent synthetase and ligase
A0130_RS05855	COG1643	Atp-dependent helicase
A0130_RS05865	COG1126	abc transporter atp-binding protein
A0130_RS05875	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
A0130_RS05885	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A0130_RS05890	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
A0130_RS05890	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A0130_RS05905	COG0667	Aldo Keto reductase
A0130_RS05915	COG1309	transcriptional regulator
A0130_RS05945	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A0130_RS05975	COG1210	Utp--glucose-1-phosphate uridylyltransferase
A0130_RS05990	COG1970	mechanosensitive ion channel activity
A0130_RS06015	COG2814	Major facilitator Superfamily
A0130_RS06085	COG2197	response regulator
A0130_RS06115	COG1733	regulation of RNA biosynthetic process
A0130_RS06120	COG0477	Major facilitator Superfamily
A0130_RS06185	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A0130_RS06205	COG0210	DNA helicase
A0130_RS06220	COG4974	Belongs to the 'phage' integrase family
A0130_RS06250	COG1321	iron dependent repressor
A0130_RS06255	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
A0130_RS06295	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
A0130_RS06305	COG0745	RESPONSE REGULATOR receiver
A0130_RS06310	COG2205	protein histidine kinase activity
A0130_RS06315	COG1216	Glycosyl transferase, family 2
A0130_RS06335	COG0459	protein refolding
A0130_RS06340	COG1278	Cold shock
A0130_RS06350	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A0130_RS06370	COG0508	dehydrogenase complex catalyzes the overall conversion of
A0130_RS06375	COG0022	dehydrogenase e1 component
A0130_RS06395	COG1024	Enoyl-CoA hydratase
A0130_RS06405	COG2050	protein possibly involved in aromatic compounds catabolism
A0130_RS06420	COG3396	Phenylacetate-CoA oxygenase
A0130_RS06425	COG3460	Phenylacetate-CoA oxygenase
A0130_RS06430	COG3396	Phenylacetate-CoA oxygenase
A0130_RS06435	COG2151	metal-sulfur cluster biosynthetic enzyme
A0130_RS06440	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A0130_RS06455	COG1196	nuclear chromosome segregation
A0130_RS06455	COG0741	lytic transglycosylase activity
A0130_RS06455	COG0739	heme binding
A0130_RS06470	COG3795	YCII-related domain
A0130_RS06475	COG2272	Belongs to the type-B carboxylesterase lipase family
A0130_RS06510	COG3842	ATPase activity
A0130_RS06525	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A0130_RS06530	COG0215	cysteine-tRNA ligase activity
A0130_RS06540	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
A0130_RS06540	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
A0130_RS06560	COG5002	protein histidine kinase activity
A0130_RS06575	COG0588	phosphoglycerate mutase activity
A0130_RS06585	COG0404	The glycine cleavage system catalyzes the degradation of glycine
A0130_RS06590	COG4044	May play a role in the intracellular transport of hydrophobic ligands
A0130_RS06600	COG0745	RESPONSE REGULATOR receiver
A0130_RS06605	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
A0130_RS06640	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A0130_RS06645	COG5343	regulation of RNA biosynthetic process
A0130_RS06670	COG2755	lipolytic protein G-D-S-L family
A0130_RS06670	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
A0130_RS06675	COG0038	chloride channel
A0130_RS06690	COG0387	Pfam Sodium calcium exchanger
A0130_RS06705	COG2017	converts alpha-aldose to the beta-anomer
A0130_RS06710	COG1349	DNA-binding transcription factor activity
A0130_RS06720	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
A0130_RS06735	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
A0130_RS06740	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
A0130_RS06755	COG0395	ABC-type sugar transport system, permease component
A0130_RS06775	COG1940	carbohydrate kinase activity
A0130_RS06790	COG1349	DNA-binding transcription factor activity
A0130_RS06795	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
A0130_RS06835	COG1940	carbohydrate kinase activity
A0130_RS06845	COG0395	ABC-type sugar transport system, permease component
A0130_RS06850	COG1175	transmembrane transport
A0130_RS06860	COG1940	carbohydrate kinase activity
A0130_RS06870	COG1028	Short-chain dehydrogenase reductase Sdr
A0130_RS06905	COG4585	Histidine kinase
A0130_RS06910	COG2197	response regulator
A0130_RS06925	COG1132	(ABC) transporter
A0130_RS06930	COG1132	(ABC) transporter
A0130_RS06935	COG1834	amidinotransferase
A0130_RS06945	COG0138	bifunctional purine biosynthesis protein purh
A0130_RS06970	COG0045	succinate-CoA ligase (ADP-forming) activity
A0130_RS06995	COG0584	glycerophosphoryl diester phosphodiesterase
A0130_RS07010	COG0519	Catalyzes the synthesis of GMP from XMP
A0130_RS07010	COG0518	GMP synthase (glutamine-hydrolyzing) activity
A0130_RS07025	COG0475	glutathione-regulated potassium exporter activity
A0130_RS07035	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
A0130_RS07040	COG0516	GMP reductase activity
A0130_RS07045	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
A0130_RS07050	COG0596	Alpha beta hydrolase
A0130_RS07065	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
A0130_RS07080	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
A0130_RS07085	COG0456	acetyltransferase
A0130_RS07085	COG1214	PFAM Peptidase M22, glycoprotease
A0130_RS07095	COG0802	atpase or kinase
A0130_RS07100	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A0130_RS07110	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A0130_RS07115	COG1072	(Pantothenic acid kinase))
A0130_RS07130	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
A0130_RS07135	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
A0130_RS07140	COG4585	Histidine kinase
A0130_RS07145	COG2197	response regulator
A0130_RS07150	COG4221	oxidoreductase activity
A0130_RS07160	COG0101	tRNA pseudouridine synthase activity
A0130_RS07170	COG0203	ribosomal protein L17
A0130_RS07175	COG0202	RNA polymerase activity
A0130_RS07180	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
A0130_RS07185	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
A0130_RS07190	COG0257	Belongs to the bacterial ribosomal protein bL36 family
A0130_RS07195	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
A0130_RS07200	COG0024	Methionine aminopeptidase
A0130_RS07205	COG0563	adenylate kinase activity
A0130_RS07215	COG0200	Binds to the 23S rRNA
A0130_RS07220	COG1841	ribosomal large subunit assembly
A0130_RS07225	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
A0130_RS07230	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
A0130_RS07235	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
A0130_RS07240	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
A0130_RS07245	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
A0130_RS07250	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
A0130_RS07255	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
A0130_RS07260	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
A0130_RS07265	COG0255	Belongs to the universal ribosomal protein uL29 family
A0130_RS07270	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
A0130_RS07275	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
A0130_RS07280	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
A0130_RS07285	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
A0130_RS07290	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
A0130_RS07295	COG0089	rRNA binding
A0130_RS07300	COG0088	Forms part of the polypeptide exit tunnel
A0130_RS07310	COG0051	transcription antitermination factor activity, RNA binding
A0130_RS07315	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A0130_RS07320	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A0130_RS07325	COG0049	tRNA binding
A0130_RS07330	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
A0130_RS07395	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
A0130_RS07415	COG2165	general secretion pathway protein
A0130_RS07420	COG1459	type II secretion system
A0130_RS07430	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A0130_RS07440	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
A0130_RS07445	COG0085	RNA polymerase activity
A0130_RS07450	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
A0130_RS07465	COG2197	response regulator
A0130_RS07490	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
A0130_RS07495	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
A0130_RS07535	COG1673	EVE domain
A0130_RS07545	COG4941	Belongs to the sigma-70 factor family
A0130_RS07565	COG0513	Belongs to the DEAD box helicase family
A0130_RS07595	COG1201	RNA secondary structure unwinding
A0130_RS07600	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
A0130_RS07605	COG0431	NADPH-dependent FMN reductase
A0130_RS07620	COG1316	TRANSCRIPTIONal
A0130_RS07625	COG0028	Belongs to the TPP enzyme family
A0130_RS07645	COG1268	BioY protein
A0130_RS07650	COG1122	ATPase activity
A0130_RS07670	COG0583	DNA-binding transcription factor activity
A0130_RS07685	COG3853	Toxic anion resistance protein (TelA)
A0130_RS07700	COG2267	carboxylic ester hydrolase activity
A0130_RS07720	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A0130_RS07730	COG1846	Transcriptional regulator
A0130_RS07760	COG2130	NADP-dependent
A0130_RS07765	COG0477	Major facilitator Superfamily
A0130_RS07770	COG3548	integral membrane protein
A0130_RS07790	COG1063	alcohol dehydrogenase
A0130_RS07805	COG4221	oxidoreductase activity
A0130_RS07830	COG2501	S4 domain
A0130_RS07855	COG0477	Major facilitator Superfamily
A0130_RS07875	COG0531	amino acid
A0130_RS07885	COG0019	diaminopimelate decarboxylase activity
A0130_RS07910	COG1116	anion transmembrane transporter activity
A0130_RS07915	COG3290	protein histidine kinase activity
A0130_RS07920	COG3290	protein histidine kinase activity
A0130_RS07925	COG4565	transcriptional regulatory protein
A0130_RS07940	COG5002	protein histidine kinase activity
A0130_RS07995	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
A0130_RS08010	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
A0130_RS08040	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A0130_RS08045	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
A0130_RS08050	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
A0130_RS08075	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
A0130_RS08080	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
A0130_RS08090	COG0302	gtp cyclohydrolase
A0130_RS08095	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A0130_RS08110	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
A0130_RS08115	COG0791	NLP P60 protein
A0130_RS08120	COG0739	heme binding
A0130_RS08120	COG1196	nuclear chromosome segregation
A0130_RS08120	COG0741	lytic transglycosylase activity
A0130_RS08140	COG0860	N-Acetylmuramoyl-L-alanine amidase
A0130_RS08140	COG2247	cell wall binding repeat
A0130_RS08185	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
A0130_RS08185	COG1672	PFAM Archaeal ATPase
A0130_RS08190	COG2197	response regulator
A0130_RS08195	COG0477	Major facilitator Superfamily
A0130_RS08245	COG1126	abc transporter atp-binding protein
A0130_RS08265	COG2873	o-acetylhomoserine
A0130_RS08285	COG1940	carbohydrate kinase activity
A0130_RS08305	COG0395	ABC-type sugar transport system, permease component
A0130_RS08320	COG1131	(ABC) transporter
A0130_RS08325	COG0667	Aldo Keto reductase
A0130_RS08345	COG2135	peptidase activity
A0130_RS08350	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A0130_RS08375	COG0673	inositol 2-dehydrogenase activity
A0130_RS08380	COG0438	transferase activity, transferring glycosyl groups
A0130_RS08395	COG0489	protein tyrosine kinase activity
A0130_RS08415	COG0438	transferase activity, transferring glycosyl groups
A0130_RS08465	COG0039	L-malate dehydrogenase activity
A0130_RS08480	COG0514	ATP-dependent DNA helicase (RecQ)
A0130_RS08500	COG2814	Major facilitator Superfamily
A0130_RS08510	COG0577	efflux transmembrane transporter activity
A0130_RS08510	COG1136	(ABC) transporter
A0130_RS08515	COG1136	(ABC) transporter
A0130_RS08530	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
A0130_RS08535	COG0477	Major facilitator Superfamily
A0130_RS08580	COG0586	Pfam SNARE associated Golgi protein
A0130_RS08585	COG0662	Cupin 2, conserved barrel domain protein
A0130_RS08590	COG1793	dna ligase
A0130_RS08600	COG1028	Short-chain dehydrogenase reductase Sdr
A0130_RS08610	COG0596	Alpha beta hydrolase
A0130_RS08620	COG2957	Belongs to the agmatine deiminase family
A0130_RS08625	COG0154	amidase activity
A0130_RS08640	COG0137	argininosuccinate synthase activity
A0130_RS08645	COG1846	Transcriptional regulator
A0130_RS08650	COG4977	sequence-specific DNA binding
A0130_RS08665	COG0515	serine threonine protein kinase
A0130_RS08695	COG1012	belongs to the aldehyde dehydrogenase family
A0130_RS08705	COG0513	Belongs to the DEAD box helicase family
A0130_RS08725	COG0783	Belongs to the Dps family
A0130_RS08735	COG2986	histidine ammonia-lyase
A0130_RS08740	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
A0130_RS08745	COG1228	amidohydrolase
A0130_RS08750	COG0010	Belongs to the arginase family
A0130_RS08755	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A0130_RS08760	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A0130_RS08765	COG2364	Membrane
A0130_RS08775	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A0130_RS08780	COG0531	amino acid
A0130_RS08785	COG1695	Transcriptional regulator
A0130_RS08800	COG1609	Transcriptional regulator
A0130_RS08810	COG1175	transmembrane transport
A0130_RS08815	COG0395	ABC-type sugar transport system, permease component
A0130_RS08820	COG3340	Belongs to the peptidase S51 family
A0130_RS08845	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
A0130_RS08865	COG0151	Belongs to the GarS family
A0130_RS08870	COG0277	FAD linked oxidase domain protein
A0130_RS08885	COG2755	lipolytic protein G-D-S-L family
A0130_RS08890	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
A0130_RS08900	COG2514	catechol 2,3-dioxygenase activity
A0130_RS08940	COG3483	tryptophan 2,3-dioxygenase activity
A0130_RS08960	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A0130_RS08965	COG0047	phosphoribosylformylglycinamidine synthase activity
A0130_RS08980	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A0130_RS08990	COG0697	spore germination
A0130_RS09010	COG1216	Glycosyl transferase, family 2
A0130_RS09030	COG1136	(ABC) transporter
A0130_RS09040	COG1605	Chorismate mutase
A0130_RS09040	COG0287	Prephenate dehydrogenase
A0130_RS09055	COG4552	Acetyltransferase involved in intracellular survival and related
A0130_RS09060	COG0477	Major facilitator Superfamily
A0130_RS09065	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
A0130_RS09085	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
A0130_RS09110	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
A0130_RS09130	COG0531	amino acid
A0130_RS09135	COG0300	oxidoreductase activity
A0130_RS09150	COG1028	Short-chain dehydrogenase reductase Sdr
A0130_RS09170	COG0395	ABC-type sugar transport system, permease component
A0130_RS09185	COG1609	Transcriptional regulator
A0130_RS09195	COG0456	acetyltransferase
A0130_RS09205	COG1210	Utp--glucose-1-phosphate uridylyltransferase
A0130_RS09210	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
A0130_RS09220	COG1215	transferase activity, transferring glycosyl groups
A0130_RS09250	COG2813	Specifically methylates the guanine in position
A0130_RS09255	COG0531	amino acid
A0130_RS09275	COG0598	Magnesium transport protein CorA
A0130_RS09285	COG0156	8-amino-7-oxononanoate synthase activity
A0130_RS09290	COG1063	alcohol dehydrogenase
A0130_RS09295	COG1335	isochorismatase
A0130_RS09300	COG0789	Transcriptional regulator
A0130_RS09305	COG0484	heat shock protein binding
A0130_RS09310	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
A0130_RS09315	COG0443	Heat shock 70 kDa protein
A0130_RS09320	COG0477	Major facilitator Superfamily
A0130_RS09325	COG0477	Major facilitator Superfamily
A0130_RS09330	COG2357	RelA SpoT domain protein
A0130_RS09345	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
A0130_RS09350	COG1752	Esterase of the alpha-beta hydrolase superfamily
A0130_RS09365	COG0717	Belongs to the dCTP deaminase family
A0130_RS09370	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A0130_RS09380	COG0688	phosphatidylethanolamine metabolic process
A0130_RS09385	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
A0130_RS09395	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
A0130_RS09400	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
A0130_RS09405	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
A0130_RS09445	COG2217	Heavy metal translocating P-type atpase
A0130_RS09450	COG1937	Protein conserved in bacteria
A0130_RS09470	COG2132	Multicopper oxidase
A0130_RS09495	COG0640	Transcriptional regulator
A0130_RS09515	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A0130_RS09520	COG1937	Protein conserved in bacteria
A0130_RS09620	COG2814	Major facilitator Superfamily
A0130_RS09635	COG3842	ATPase activity
A0130_RS09640	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
A0130_RS09645	COG1176	ABC-type spermidine putrescine transport system, permease component I
A0130_RS09665	COG0667	Aldo Keto reductase
A0130_RS09680	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A0130_RS09690	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A0130_RS09715	COG1595	DNA-templated transcription, initiation
A0130_RS09725	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
A0130_RS09760	COG0583	DNA-binding transcription factor activity
A0130_RS09770	COG4221	oxidoreductase activity
A0130_RS09785	COG0604	alcohol dehydrogenase
A0130_RS09795	COG1793	dna ligase
A0130_RS09795	COG3285	dna ligase
A0130_RS09800	COG1621	beta-fructofuranosidase activity
A0130_RS09830	COG1609	Transcriptional regulator
A0130_RS09835	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A0130_RS09890	COG1475	DNA binding
A0130_RS09930	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A0130_RS09935	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A0130_RS09945	COG3387	PFAM Glycoside hydrolase 15-related
A0130_RS09975	COG4948	Mandelate Racemase Muconate Lactonizing
A0130_RS09990	COG0302	gtp cyclohydrolase
A0130_RS09995	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
A0130_RS10115	COG0515	serine threonine protein kinase
A0130_RS10115	COG2815	serine threonine protein kinase
A0130_RS10135	COG1316	TRANSCRIPTIONal
A0130_RS10140	COG0561	phosphatase activity
A0130_RS10145	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
A0130_RS10160	COG0077	Prephenate dehydratase
A0130_RS10175	COG1876	peptidase activity
A0130_RS10185	COG0477	Major facilitator Superfamily
A0130_RS10190	COG1653	transport
A0130_RS10200	COG0395	ABC-type sugar transport system, permease component
A0130_RS10205	COG2723	6-phospho-beta-galactosidase activity
A0130_RS10230	COG2189	Belongs to the N(4) N(6)-methyltransferase family
A0130_RS10240	COG0189	ligase activity
A0130_RS10240	COG4067	protein conserved in archaea
A0130_RS10245	COG0569	domain protein
A0130_RS10245	COG0189	ligase activity
A0130_RS10265	COG0531	amino acid
A0130_RS10270	COG0076	glutamate decarboxylase activity
A0130_RS10310	COG0395	ABC-type sugar transport system, permease component
A0130_RS10315	COG1175	transmembrane transport
A0130_RS10320	COG1653	transport
A0130_RS10335	COG2222	sugar isomerase
A0130_RS10340	COG1028	Short-chain dehydrogenase reductase Sdr
A0130_RS10400	COG0745	RESPONSE REGULATOR receiver
A0130_RS10425	COG3511	phospholipase C
A0130_RS10445	COG0494	nUDIX hydrolase
A0130_RS10455	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A0130_RS10465	COG4989	oxidoreductase activity
A0130_RS10500	COG2890	protein-(glutamine-N5) methyltransferase activity
A0130_RS10520	COG0723	plastoquinol--plastocyanin reductase activity
A0130_RS10535	COG0438	transferase activity, transferring glycosyl groups
A0130_RS10565	COG1486	melibiose metabolic process
A0130_RS10575	COG1609	Transcriptional regulator
A0130_RS10580	COG1175	transmembrane transport
A0130_RS10585	COG0395	ABC-type sugar transport system, permease component
A0130_RS10630	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
A0130_RS10640	COG0640	Transcriptional regulator
A0130_RS10645	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
A0130_RS10655	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A0130_RS10685	COG1349	DNA-binding transcription factor activity
A0130_RS10690	COG3395	kinase activity
A0130_RS10695	COG0235	Class ii aldolase
A0130_RS10700	COG1132	(ABC) transporter
A0130_RS10755	COG1028	Short-chain dehydrogenase reductase Sdr
A0130_RS10820	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
A0130_RS10830	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
A0130_RS10835	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
A0130_RS10840	COG1684	flagellar biosynthetic protein fliR
A0130_RS10850	COG1338	Plays a role in the flagellum-specific transport system
A0130_RS10895	COG3534	alpha-L-arabinofuranosidase
A0130_RS10900	COG0395	ABC-type sugar transport system, permease component
A0130_RS10920	COG0390	transport system, permease component
A0130_RS10930	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
A0130_RS10940	COG0791	NLP P60 protein
A0130_RS10950	COG1157	protein secretion by the type III secretion system
A0130_RS10960	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
A0130_RS10965	COG1766	The M ring may be actively involved in energy transduction
A0130_RS10970	COG1677	Flagellar hook-basal body complex protein FliE
A0130_RS10975	COG1558	bacterial-type flagellum-dependent cell motility
A0130_RS11000	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
A0130_RS11005	COG1191	sigma factor activity
A0130_RS11015	COG4786	Flagellar basal body rod
A0130_RS11015	COG1256	bacterial-type flagellum assembly
A0130_RS11020	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
A0130_RS11025	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
A0130_RS11050	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A0130_RS11065	COG0776	regulation of translation
A0130_RS11070	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
A0130_RS11075	COG0267	Belongs to the bacterial ribosomal protein bL33 family
A0130_RS11080	COG0227	Belongs to the bacterial ribosomal protein bL28 family
A0130_RS11095	COG3842	ATPase activity
A0130_RS11115	COG0508	dehydrogenase complex catalyzes the overall conversion of
A0130_RS11120	COG0022	dehydrogenase e1 component
A0130_RS11130	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A0130_RS11140	COG1950	PFAM Membrane protein of
A0130_RS11145	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A0130_RS11170	COG1902	pentaerythritol trinitrate reductase activity
A0130_RS11180	COG0305	Participates in initiation and elongation during chromosome replication
A0130_RS11185	COG0359	binds to the 23S rRNA
A0130_RS11190	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
A0130_RS11200	COG0360	Binds together with S18 to 16S ribosomal RNA
A0130_RS11205	COG0617	tRNA 3'-terminal CCA addition
A0130_RS11220	COG0492	ferredoxin-NADP+ reductase activity
A0130_RS11225	COG3118	belongs to the thioredoxin family
A0130_RS11230	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A0130_RS11235	COG1181	Belongs to the D-alanine--D-alanine ligase family
A0130_RS11245	COG1192	Involved in chromosome partitioning
A0130_RS11250	COG0357	Ribosomal RNA small subunit methyltransferase G
A0130_RS11260	COG0706	membrane insertase activity
A0130_RS11265	COG0230	Belongs to the bacterial ribosomal protein bL34 family
A0130_RS11270	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
A0130_RS11275	COG0592	DNA-directed DNA polymerase activity
A0130_RS11280	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
A0130_RS11285	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
A0130_RS11290	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
A0130_RS11295	COG0187	DNA topoisomerase II activity
A0130_RS11300	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A0130_RS11330	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
A0130_RS11365	COG3764	Sortase (surface protein transpeptidase)
A0130_RS11375	COG2815	serine threonine protein kinase
A0130_RS11375	COG0515	serine threonine protein kinase
A0130_RS11380	COG0515	serine threonine protein kinase
A0130_RS11385	COG0768	penicillin binding
A0130_RS11400	COG1716	ATPase activity
A0130_RS11405	COG1716	ATPase activity
A0130_RS11435	COG1477	protein flavinylation
A0130_RS11460	COG3300	MHYT domain
A0130_RS11460	COG5001	Diguanylate cyclase
A0130_RS11510	COG0789	Transcriptional regulator
A0130_RS11515	COG1846	Transcriptional regulator
A0130_RS11525	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A0130_RS11530	COG1280	lysine exporter protein (LysE YggA)
A0130_RS11545	COG4214	carbohydrate transport
A0130_RS11560	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A0130_RS11625	COG0494	nUDIX hydrolase
A0130_RS11630	COG1295	ribonuclease BN
A0130_RS11650	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
A0130_RS11655	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
A0130_RS11675	COG2814	Major facilitator Superfamily
A0130_RS11695	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A0130_RS11710	COG0246	Mannitol dehydrogenase
A0130_RS11715	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
A0130_RS11725	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A0130_RS11740	COG3711	transcriptional antiterminator
A0130_RS11740	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A0130_RS11760	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
A0130_RS11765	COG2706	6-phosphogluconolactonase activity
A0130_RS11770	COG0738	Major facilitator superfamily
A0130_RS11785	COG0534	Mate efflux family protein
A0130_RS11800	COG1131	(ABC) transporter
A0130_RS11820	COG3590	peptidase
A0130_RS11835	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
A0130_RS11845	COG0423	glycine-tRNA ligase activity
A0130_RS11855	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A0130_RS11860	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
A0130_RS11865	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
A0130_RS11890	COG3253	May function as heme-dependent peroxidase
A0130_RS11895	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
A0130_RS11900	COG0181	hydroxymethylbilane synthase activity
A0130_RS11910	COG0113	porphobilinogen synthase activity
A0130_RS11915	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
A0130_RS11925	COG4214	carbohydrate transport
A0130_RS11935	COG4213	ABC transporter substrate-binding protein
A0130_RS11960	COG0604	alcohol dehydrogenase
A0130_RS11965	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
A0130_RS11980	COG1054	Belongs to the UPF0176 family
A0130_RS11985	COG1216	Glycosyl transferase, family 2
A0130_RS11990	COG1881	PFAM PEBP family protein
A0130_RS11995	COG1280	lysine exporter protein (LysE YggA)
A0130_RS12000	COG2079	MmgE PrpD family protein
A0130_RS12005	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
A0130_RS12015	COG0183	Belongs to the thiolase family
A0130_RS12020	COG0017	Asparaginyl-tRNA synthetase
A0130_RS12030	COG0406	alpha-ribazole phosphatase activity
A0130_RS12040	COG0785	Cytochrome C biogenesis protein
A0130_RS12050	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A0130_RS12075	COG0647	UMP catabolic process
A0130_RS12080	COG4948	Mandelate Racemase Muconate Lactonizing
A0130_RS12090	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A0130_RS12145	COG1012	belongs to the aldehyde dehydrogenase family
A0130_RS12150	COG0656	L-ascorbic acid biosynthetic process
A0130_RS12155	COG2205	protein histidine kinase activity
A0130_RS12160	COG0745	RESPONSE REGULATOR receiver
A0130_RS12170	COG3104	oligopeptide transport
A0130_RS12185	COG1733	regulation of RNA biosynthetic process
A0130_RS12205	COG0667	Aldo Keto reductase
A0130_RS12210	COG0667	Aldo Keto reductase
A0130_RS12240	COG2267	carboxylic ester hydrolase activity
A0130_RS12260	COG1929	Belongs to the glycerate kinase type-1 family
A0130_RS12295	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A0130_RS12310	COG0739	heme binding
A0130_RS12320	COG0477	Major facilitator Superfamily
A0130_RS12345	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A0130_RS12350	COG0454	-acetyltransferase
A0130_RS12355	COG3387	PFAM Glycoside hydrolase 15-related
A0130_RS12360	COG0515	serine threonine protein kinase
A0130_RS12390	COG1846	Transcriptional regulator
A0130_RS12400	COG3237	CsbD-like
A0130_RS12425	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A0130_RS12430	COG0765	amino acid transport
A0130_RS12435	COG1126	abc transporter atp-binding protein
A0130_RS12440	COG0673	inositol 2-dehydrogenase activity
A0130_RS12450	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A0130_RS12455	COG0596	Alpha beta hydrolase
A0130_RS12510	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A0130_RS12535	COG2207	Transcriptional regulator
A0130_RS12555	COG1309	transcriptional regulator
A0130_RS12560	COG1028	Short-chain dehydrogenase reductase Sdr
A0130_RS12575	COG0395	ABC-type sugar transport system, permease component
A0130_RS12580	COG1175	transmembrane transport
A0130_RS12585	COG1609	Transcriptional regulator
A0130_RS12630	COG0514	ATP-dependent DNA helicase (RecQ)
A0130_RS12675	COG0640	Transcriptional regulator
A0130_RS12705	COG0693	protein deglycase activity
A0130_RS12710	COG0656	L-ascorbic acid biosynthetic process
A0130_RS12715	COG0860	N-Acetylmuramoyl-L-alanine amidase
A0130_RS12715	COG2247	cell wall binding repeat
A0130_RS12740	COG1764	response to oxidative stress
A0130_RS12745	COG1846	Transcriptional regulator
A0130_RS12750	COG1940	carbohydrate kinase activity
A0130_RS12765	COG0765	amino acid transport
A0130_RS12770	COG0765	amino acid transport
A0130_RS12780	COG1126	abc transporter atp-binding protein
A0130_RS12795	COG0366	Alpha amylase catalytic
A0130_RS12810	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A0130_RS12820	COG2226	methyltransferase
A0130_RS12845	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
A0130_RS12855	COG0505	Belongs to the CarA family
A0130_RS12865	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A0130_RS12875	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A0130_RS12880	COG0640	Transcriptional regulator
A0130_RS12910	COG2326	polyphosphate kinase activity
A0130_RS12920	COG2226	methyltransferase
A0130_RS12925	COG0142	geranyltranstransferase activity
A0130_RS12940	COG1666	GTP binding
A0130_RS12955	COG1396	sequence-specific DNA binding
A0130_RS12980	COG1609	Transcriptional regulator
A0130_RS12985	COG1357	PFAM Pentapeptide repeats (8 copies)
A0130_RS12990	COG0667	Aldo Keto reductase
A0130_RS13005	COG3321	synthase
A0130_RS13005	COG0604	alcohol dehydrogenase
A0130_RS13005	COG1028	Short-chain dehydrogenase reductase Sdr
A0130_RS13040	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A0130_RS13045	COG3002	Belongs to the UPF0753 family
A0130_RS13065	COG0667	Aldo Keto reductase
A0130_RS13090	COG0583	DNA-binding transcription factor activity
A0130_RS13115	COG4948	Mandelate Racemase Muconate Lactonizing
A0130_RS13120	COG0028	Belongs to the TPP enzyme family
A0130_RS13145	COG3387	PFAM Glycoside hydrolase 15-related
A0130_RS13150	COG1028	Short-chain dehydrogenase reductase Sdr
A0130_RS13155	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A0130_RS13160	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A0130_RS13175	COG3422	double-strand break repair
A0130_RS13180	COG1609	Transcriptional regulator
A0130_RS13195	COG1175	transmembrane transport
A0130_RS13200	COG0395	ABC-type sugar transport system, permease component
A0130_RS13290	COG2066	Belongs to the glutaminase family
A0130_RS13300	COG1028	Short-chain dehydrogenase reductase Sdr
A0130_RS13305	COG1176	ABC-type spermidine putrescine transport system, permease component I
A0130_RS13310	COG1177	transmembrane transport
A0130_RS13320	COG3842	ATPase activity
A0130_RS13325	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A0130_RS13330	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
A0130_RS13355	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A0130_RS13375	COG1309	transcriptional regulator
A0130_RS13380	COG3250	beta-galactosidase activity
A0130_RS13390	COG0477	Major facilitator Superfamily
A0130_RS13430	COG1175	transmembrane transport
A0130_RS13435	COG0395	ABC-type sugar transport system, permease component
A0130_RS13460	COG3622	Belongs to the hyi family
A0130_RS13485	COG1082	Xylose isomerase domain protein TIM barrel
A0130_RS13505	COG0673	inositol 2-dehydrogenase activity
A0130_RS13565	COG1846	Transcriptional regulator
A0130_RS13565	COG1940	carbohydrate kinase activity
A0130_RS13580	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A0130_RS13650	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A0130_RS13675	COG0640	Transcriptional regulator
A0130_RS13680	COG3548	integral membrane protein
A0130_RS13710	COG1028	Short-chain dehydrogenase reductase Sdr
A0130_RS13725	COG3485	protocatechuate 3,4-dioxygenase
A0130_RS13730	COG3485	protocatechuate 3,4-dioxygenase
A0130_RS13740	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A0130_RS13755	COG0183	Belongs to the thiolase family
A0130_RS13760	COG0667	Aldo Keto reductase
A0130_RS13790	COG1309	transcriptional regulator
A0130_RS13810	COG2733	membrane
A0130_RS13855	COG0395	ABC-type sugar transport system, permease component
A0130_RS13910	COG0596	Alpha beta hydrolase
A0130_RS13950	COG1472	Belongs to the glycosyl hydrolase 3 family
A0130_RS13965	COG3250	beta-galactosidase activity
A0130_RS13975	COG1175	transmembrane transport
A0130_RS13980	COG0395	ABC-type sugar transport system, permease component
A0130_RS13995	COG2249	NAD(P)H dehydrogenase (quinone) activity
A0130_RS14005	COG3237	CsbD-like
A0130_RS14070	COG2326	polyphosphate kinase activity
A0130_RS14100	COG3619	membrane
A0130_RS14105	COG0531	amino acid
A0130_RS14125	COG1278	Cold shock
A0130_RS14175	COG4213	ABC transporter substrate-binding protein
A0130_RS14185	COG4214	carbohydrate transport
A0130_RS14195	COG1609	Transcriptional regulator
A0130_RS14200	COG1653	transport
A0130_RS14205	COG1175	transmembrane transport
A0130_RS14235	COG2160	L-arabinose isomerase activity
A0130_RS14250	COG1609	Transcriptional regulator
A0130_RS14265	COG2017	converts alpha-aldose to the beta-anomer
A0130_RS14310	COG0025	NhaP-type Na H and K H
A0130_RS14345	COG1136	(ABC) transporter
A0130_RS14350	COG4591	ABC-type transport system involved in lipoprotein release permease component
A0130_RS14350	COG1136	(ABC) transporter
A0130_RS14365	COG2030	dehydratase
A0130_RS14375	COG0812	UDP-N-acetylmuramate dehydrogenase activity
A0130_RS14385	COG0514	ATP-dependent DNA helicase (RecQ)
A0130_RS14405	COG2197	response regulator
A0130_RS14415	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A0130_RS14425	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
A0130_RS14430	COG0081	regulation of translation
A0130_RS14445	COG3321	synthase
A0130_RS14445	COG0604	alcohol dehydrogenase
A0130_RS14465	COG0673	inositol 2-dehydrogenase activity
A0130_RS14480	COG0673	inositol 2-dehydrogenase activity
A0130_RS14485	COG0673	inositol 2-dehydrogenase activity
A0130_RS14495	COG2764	glyoxalase bleomycin resistance protein dioxygenase
A0130_RS14500	COG2378	regulation of single-species biofilm formation
A0130_RS14525	COG1136	(ABC) transporter
A0130_RS14545	COG0745	RESPONSE REGULATOR receiver
A0130_RS14550	COG2205	protein histidine kinase activity
A0130_RS14555	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
A0130_RS14560	COG0222	ribosome binding
A0130_RS14575	COG2814	Major facilitator Superfamily
A0130_RS14585	COG1609	Transcriptional regulator
A0130_RS14650	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
A0130_RS14675	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
A0130_RS14685	COG1609	Transcriptional regulator
A0130_RS14695	COG2186	Transcriptional regulator
A0130_RS14705	COG3265	gluconokinase activity
A0130_RS14715	COG2115	Belongs to the xylose isomerase family
A0130_RS14720	COG1472	Belongs to the glycosyl hydrolase 3 family
A0130_RS14725	COG0395	ABC-type sugar transport system, permease component
A0130_RS14740	COG1609	Transcriptional regulator
A0130_RS14745	COG3458	cephalosporin-C deacetylase activity
A0130_RS14750	COG1609	Transcriptional regulator
A0130_RS14755	COG0673	inositol 2-dehydrogenase activity
A0130_RS14765	COG0673	inositol 2-dehydrogenase activity
A0130_RS14775	COG2814	Major facilitator Superfamily
A0130_RS14780	COG0671	phosphoesterase, PA-phosphatase related
A0130_RS14785	COG0433	COG0433 Predicted ATPase
A0130_RS14870	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
A0130_RS14895	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
A0130_RS14910	COG0579	oxidoreductase
A0130_RS14915	COG0488	(ABC) transporter
A0130_RS14945	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
A0130_RS14960	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A0130_RS14965	COG0431	NADPH-dependent FMN reductase
A0130_RS14990	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A0130_RS15025	COG1754	DNA topoisomerase type I activity
A0130_RS15025	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A0130_RS15030	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
A0130_RS15035	COG0470	DNA polymerase III
A0130_RS15060	COG3548	integral membrane protein
A0130_RS15080	COG2027	D-alanyl-D-alanine carboxypeptidase
A0130_RS15085	COG1335	isochorismatase
A0130_RS15090	COG2409	Drug exporters of the RND superfamily
A0130_RS15095	COG2267	carboxylic ester hydrolase activity
A0130_RS15100	COG1522	sequence-specific DNA binding
A0130_RS15110	COG0183	Belongs to the thiolase family
A0130_RS15125	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
A0130_RS15130	COG1132	(ABC) transporter
A0130_RS15135	COG1131	(ABC) transporter
A0130_RS15150	COG0477	Major facilitator Superfamily
A0130_RS15160	COG0640	Transcriptional regulator
A0130_RS15175	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
A0130_RS15180	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A0130_RS15180	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A0130_RS15195	COG2390	Transcriptional regulator
A0130_RS15200	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
A0130_RS15205	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A0130_RS15210	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
A0130_RS15215	COG1011	Hydrolase
A0130_RS15220	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A0130_RS15225	COG0180	Tryptophanyl-tRNA synthetase
A0130_RS15230	COG0708	Exodeoxyribonuclease III
A0130_RS15245	COG1053	succinate dehydrogenase
A0130_RS15255	COG2009	succinate dehydrogenase
A0130_RS15265	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
A0130_RS15265	COG0662	Cupin 2, conserved barrel domain protein
A0130_RS15275	COG0598	Magnesium transport protein CorA
A0130_RS15285	COG3845	ABC transporter
A0130_RS15290	COG4603	Belongs to the binding-protein-dependent transport system permease family
A0130_RS15295	COG1079	Belongs to the binding-protein-dependent transport system permease family
A0130_RS15310	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
A0130_RS15315	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A0130_RS15325	COG0640	Transcriptional regulator
A0130_RS15335	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A0130_RS15350	COG0025	NhaP-type Na H and K H
A0130_RS15360	COG4770	biotin carboxylase activity
A0130_RS15365	COG0424	maF-like protein
A0130_RS15370	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A0130_RS15395	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A0130_RS15420	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
A0130_RS15425	COG1316	TRANSCRIPTIONal
A0130_RS15445	COG0438	transferase activity, transferring glycosyl groups
A0130_RS15505	COG0438	transferase activity, transferring glycosyl groups
A0130_RS15550	COG1216	Glycosyl transferase, family 2
A0130_RS15590	COG1482	cell wall glycoprotein biosynthetic process
A0130_RS15595	COG1960	acyl-CoA dehydrogenase activity
A0130_RS15630	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A0130_RS15635	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
A0130_RS15640	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A0130_RS15665	COG0714	Associated with various cellular activities
A0130_RS15685	COG0745	RESPONSE REGULATOR receiver
A0130_RS15690	COG5002	protein histidine kinase activity
A0130_RS15695	COG5401	PFAM Sporulation and spore germination
A0130_RS15700	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
A0130_RS15705	COG0653	protein targeting
A0130_RS15745	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A0130_RS15775	COG1595	DNA-templated transcription, initiation
A0130_RS15790	COG0567	Dehydrogenase, E1 component
A0130_RS15790	COG0508	dehydrogenase complex catalyzes the overall conversion of
A0130_RS15825	COG1902	pentaerythritol trinitrate reductase activity
A0130_RS15855	COG2814	Major facilitator Superfamily
A0130_RS15860	COG2197	response regulator
A0130_RS15875	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A0130_RS15880	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A0130_RS15900	COG2814	Major facilitator Superfamily
A0130_RS15905	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
A0130_RS15910	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
A0130_RS15930	COG2076	Multidrug Resistance protein
A0130_RS15945	COG2188	Transcriptional regulator
A0130_RS15965	COG0405	Gamma-glutamyltransferase
A0130_RS15975	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
A0130_RS15980	COG0291	Belongs to the bacterial ribosomal protein bL35 family
A0130_RS15985	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
A0130_RS15995	COG0667	Aldo Keto reductase
A0130_RS16010	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A0130_RS16015	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
A0130_RS16020	COG0072	phenylalanine-tRNA ligase activity
A0130_RS16020	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A0130_RS16025	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
A0130_RS16030	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
A0130_RS16035	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
A0130_RS16040	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A0130_RS16045	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A0130_RS16050	COG0165	Argininosuccinate lyase
A0130_RS16055	COG2094	Belongs to the DNA glycosylase MPG family
A0130_RS16080	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
A0130_RS16085	COG0497	DNA recombination
A0130_RS16090	COG0504	CTP synthase activity
A0130_RS16095	COG0494	nUDIX hydrolase
A0130_RS16100	COG4974	Belongs to the 'phage' integrase family
A0130_RS16120	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
A0130_RS16130	COG0287	Prephenate dehydrogenase
A0130_RS16135	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
A0130_RS16140	COG1160	GTP binding
A0130_RS16155	COG3979	chitinase
A0130_RS16180	COG2197	response regulator
A0130_RS16195	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A0130_RS16205	COG1063	alcohol dehydrogenase
A0130_RS16210	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
A0130_RS16245	COG1695	Transcriptional regulator
A0130_RS16250	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
A0130_RS16255	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A0130_RS16270	COG1609	Transcriptional regulator
A0130_RS16275	COG1129	ABC transporter
A0130_RS16280	COG1172	Belongs to the binding-protein-dependent transport system permease family
A0130_RS16295	COG3254	rhamnose metabolic process
A0130_RS16305	COG1028	Short-chain dehydrogenase reductase Sdr
A0130_RS16305	COG3347	Dehydrogenase
A0130_RS16310	COG1070	Carbohydrate kinase
A0130_RS16395	COG0477	Major facilitator Superfamily
A0130_RS16405	COG1028	Short-chain dehydrogenase reductase Sdr
A0130_RS16475	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
A0130_RS16490	COG2267	carboxylic ester hydrolase activity
A0130_RS16510	COG0628	permease
A0130_RS16520	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
A0130_RS16540	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
A0130_RS16545	COG3214	Protein conserved in bacteria
A0130_RS16555	COG3387	PFAM Glycoside hydrolase 15-related
A0130_RS16575	COG0656	L-ascorbic acid biosynthetic process
A0130_RS16580	COG0542	response to heat
A0130_RS16585	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A0130_RS16605	COG0494	nUDIX hydrolase
A0130_RS16635	COG1335	isochorismatase
A0130_RS16650	COG1793	dna ligase
A0130_RS16665	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A0130_RS16670	COG1024	Enoyl-CoA hydratase
A0130_RS16675	COG0010	Belongs to the arginase family
A0130_RS16680	COG1842	Phage shock protein A
A0130_RS16690	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
A0130_RS16695	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
A0130_RS16710	COG0395	ABC-type sugar transport system, permease component
A0130_RS16715	COG1175	transmembrane transport
A0130_RS16725	COG1846	Transcriptional regulator
A0130_RS16725	COG1940	carbohydrate kinase activity
A0130_RS16750	COG0596	Alpha beta hydrolase
A0130_RS16760	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A0130_RS16790	COG0601	transmembrane transport
A0130_RS16810	COG1309	transcriptional regulator
A0130_RS16825	COG0018	arginyl-trna synthetase
A0130_RS16845	COG0460	homoserine dehydrogenase
A0130_RS16855	COG0083	homoserine kinase activity
A0130_RS16865	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
A0130_RS16870	COG2890	protein-(glutamine-N5) methyltransferase activity
A0130_RS16880	COG1045	serine acetyltransferase
A0130_RS16905	COG0009	L-threonylcarbamoyladenylate synthase
A0130_RS16910	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A0130_RS16920	COG0356	it plays a direct role in the translocation of protons across the membrane
A0130_RS16925	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A0130_RS16930	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
A0130_RS16935	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A0130_RS16940	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
A0130_RS16945	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
A0130_RS16950	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
A0130_RS16955	COG0355	proton-transporting ATP synthase activity, rotational mechanism
A0130_RS16965	COG3022	response to hydroperoxide
A0130_RS16970	COG2818	Glycosylase
A0130_RS16975	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A0130_RS16980	COG0667	Aldo Keto reductase
A0130_RS17000	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
A0130_RS17005	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
A0130_RS17025	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
A0130_RS17035	COG1309	transcriptional regulator
A0130_RS17040	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
A0130_RS17055	COG0196	riboflavin kinase activity
A0130_RS17060	COG2807	transmembrane transport
A0130_RS17080	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
A0130_RS17085	COG1012	belongs to the aldehyde dehydrogenase family
A0130_RS17090	COG1012	belongs to the aldehyde dehydrogenase family
A0130_RS17110	COG1937	Protein conserved in bacteria
A0130_RS17125	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A0130_RS17195	COG2871	sodium ion transport
A0130_RS17200	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
A0130_RS17205	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
A0130_RS17230	COG3585	molybdate ion transport
A0130_RS17240	COG0521	Mo-molybdopterin cofactor biosynthetic process
A0130_RS17240	COG0315	cyclic pyranopterin monophosphate synthase activity
A0130_RS17275	COG2233	PERMEase
A0130_RS17280	COG2252	PERMEase
A0130_RS17290	COG0220	tRNA (guanine-N7-)-methyltransferase activity
A0130_RS17295	COG1012	belongs to the aldehyde dehydrogenase family
A0130_RS17330	COG0277	FAD linked oxidase domain protein
A0130_RS17335	COG0545	Peptidyl-prolyl cis-trans isomerase
A0130_RS17340	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A0130_RS17355	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
A0130_RS17380	COG1185	polyribonucleotide nucleotidyltransferase activity
A0130_RS17395	COG0022	dehydrogenase e1 component
A0130_RS17405	COG2171	N-acyltransferase activity
A0130_RS17410	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A0130_RS17425	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A0130_RS17460	COG0006	proline dipeptidase activity
A0130_RS17465	COG0613	PHP domain protein
A0130_RS17475	COG0513	Belongs to the DEAD box helicase family
A0130_RS17500	COG0210	DNA helicase
A0130_RS17530	COG3480	Lon protease (S16) C-terminal proteolytic domain
A0130_RS17535	COG1615	UPF0182 protein
A0130_RS17550	COG1940	carbohydrate kinase activity
A0130_RS17565	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
A0130_RS17570	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
A0130_RS17580	COG0745	RESPONSE REGULATOR receiver
A0130_RS17585	COG2205	protein histidine kinase activity
A0130_RS17585	COG2202	Pas domain