locus-tag	class	description
G8J22_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
G8J22_RS00010	COG0592	DNA-directed DNA polymerase activity
G8J22_RS00015	COG2501	S4 domain
G8J22_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
G8J22_RS00025	COG0187	DNA topoisomerase II activity
G8J22_RS00035	COG1304	FMN binding
G8J22_RS00040	COG0360	Binds together with S18 to 16S ribosomal RNA
G8J22_RS00045	COG0629	single-stranded DNA binding
G8J22_RS00050	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
G8J22_RS00060	COG0359	binds to the 23S rRNA
G8J22_RS00065	COG0305	Participates in initiation and elongation during chromosome replication
G8J22_RS00075	COG0745	RESPONSE REGULATOR receiver
G8J22_RS00080	COG5002	protein histidine kinase activity
G8J22_RS00095	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
G8J22_RS00100	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
G8J22_RS00110	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
G8J22_RS00115	COG1573	uracil-dna glycosylase
G8J22_RS00150	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
G8J22_RS00160	COG0667	Aldo Keto reductase
G8J22_RS00185	COG0584	glycerophosphoryl diester phosphodiesterase
G8J22_RS00190	COG3842	ATPase activity
G8J22_RS00195	COG1175	transmembrane transport
G8J22_RS00210	COG0584	glycerophosphoryl diester phosphodiesterase
G8J22_RS00250	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
G8J22_RS00260	COG0300	oxidoreductase activity
G8J22_RS00290	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
G8J22_RS00295	COG1914	H( )-stimulated, divalent metal cation uptake system
G8J22_RS00315	COG2357	RelA SpoT domain protein
G8J22_RS00320	COG0667	Aldo Keto reductase
G8J22_RS00325	COG0783	Belongs to the Dps family
G8J22_RS00330	COG0477	Major facilitator Superfamily
G8J22_RS00335	COG1011	Hydrolase
G8J22_RS00345	COG0028	Belongs to the TPP enzyme family
G8J22_RS00350	COG3527	Alpha-acetolactate decarboxylase
G8J22_RS00375	COG1131	(ABC) transporter
G8J22_RS00380	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
G8J22_RS00390	COG0602	queuosine metabolic process
G8J22_RS00395	COG2814	Major facilitator Superfamily
G8J22_RS00410	COG2323	membrane
G8J22_RS00420	COG1395	domain, Protein
G8J22_RS00440	COG1131	(ABC) transporter
G8J22_RS00455	COG0436	Aminotransferase
G8J22_RS00460	COG0110	maltose O-acetyltransferase activity
G8J22_RS00465	COG0477	Major facilitator Superfamily
G8J22_RS00490	COG1704	LemA family
G8J22_RS00495	COG0501	Belongs to the peptidase M48B family
G8J22_RS00500	COG0626	cystathionine gamma-synthase activity
G8J22_RS00510	COG1473	amidohydrolase
G8J22_RS00515	COG0436	Aminotransferase
G8J22_RS00520	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
G8J22_RS00530	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
G8J22_RS00535	COG0765	amino acid transport
G8J22_RS00540	COG1126	abc transporter atp-binding protein
G8J22_RS00545	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G8J22_RS00550	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
G8J22_RS00590	COG2274	protein secretion by the type I secretion system
G8J22_RS00595	COG2274	protein secretion by the type I secretion system
G8J22_RS00615	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
G8J22_RS00620	COG1114	Component of the transport system for branched-chain amino acids
G8J22_RS00640	COG0803	Belongs to the bacterial solute-binding protein 9 family
G8J22_RS00645	COG3409	Peptidoglycan-binding domain 1 protein
G8J22_RS00645	COG3757	hydrolase, family 25
G8J22_RS00660	COG1609	Transcriptional regulator
G8J22_RS00670	COG0006	proline dipeptidase activity
G8J22_RS00675	COG4720	Psort location CytoplasmicMembrane, score
G8J22_RS00680	COG1122	ATPase activity
G8J22_RS00700	COG0697	spore germination
G8J22_RS00705	COG3001	Fructosamine kinase
G8J22_RS00710	COG2918	glutathione biosynthetic process
G8J22_RS00710	COG1181	Belongs to the D-alanine--D-alanine ligase family
G8J22_RS00720	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
G8J22_RS00735	COG1132	(ABC) transporter
G8J22_RS00740	COG1132	(ABC) transporter
G8J22_RS00775	COG1309	transcriptional regulator
G8J22_RS00790	COG0778	Nitroreductase
G8J22_RS00795	COG0765	amino acid transport
G8J22_RS00800	COG0765	amino acid transport
G8J22_RS00815	COG0738	Major facilitator superfamily
G8J22_RS00820	COG0710	3-dehydroquinate dehydratase activity
G8J22_RS00825	COG4377	Putative membrane peptidase family (DUF2324)
G8J22_RS00830	COG0726	polysaccharide deacetylase
G8J22_RS00845	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
G8J22_RS00850	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
G8J22_RS00860	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
G8J22_RS00865	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
G8J22_RS00875	COG0738	Major facilitator superfamily
G8J22_RS00880	COG1869	D-ribose catabolic process
G8J22_RS00885	COG1609	Transcriptional regulator
G8J22_RS00890	COG2190	(PTS) system
G8J22_RS00890	COG2211	Major facilitator Superfamily
G8J22_RS00900	COG0477	Major facilitator Superfamily
G8J22_RS00925	COG1028	Short-chain dehydrogenase reductase Sdr
G8J22_RS00935	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
G8J22_RS00945	COG0540	Belongs to the ATCase OTCase family
G8J22_RS00950	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
G8J22_RS00955	COG0494	nUDIX hydrolase
G8J22_RS00975	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
G8J22_RS00980	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
G8J22_RS00990	COG4166	transmembrane transport
G8J22_RS01000	COG2226	methyltransferase
G8J22_RS01005	COG0251	oxidation-reduction process
G8J22_RS01010	COG1309	transcriptional regulator
G8J22_RS01020	COG1131	(ABC) transporter
G8J22_RS01025	COG0436	Aminotransferase
G8J22_RS01030	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
G8J22_RS01040	COG0095	Lipoate-protein ligase
G8J22_RS01045	COG1132	(ABC) transporter
G8J22_RS01055	COG0386	Belongs to the glutathione peroxidase family
G8J22_RS01075	COG1694	Mazg nucleotide pyrophosphohydrolase
G8J22_RS01090	COG1136	(ABC) transporter
G8J22_RS01100	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
G8J22_RS01105	COG0509	glycine decarboxylation via glycine cleavage system
G8J22_RS01110	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
G8J22_RS01115	COG2151	metal-sulfur cluster biosynthetic enzyme
G8J22_RS01125	COG2197	response regulator
G8J22_RS01160	COG2217	Heavy metal translocating P-type atpase
G8J22_RS01170	COG1953	Uracil, thiamine, allantoin
G8J22_RS01175	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
G8J22_RS01185	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
G8J22_RS01190	COG3257	ureidoglycine aminohydrolase activity
G8J22_RS01195	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
G8J22_RS01200	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
G8J22_RS01205	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
G8J22_RS01225	COG2508	Transcriptional regulator
G8J22_RS01245	COG1288	antiporter activity
G8J22_RS01250	COG4191	Histidine kinase
G8J22_RS01255	COG0784	Response regulator, receiver
G8J22_RS01260	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
G8J22_RS01265	COG0531	amino acid
G8J22_RS01270	COG2957	Belongs to the agmatine deiminase family
G8J22_RS01330	COG0667	Aldo Keto reductase
G8J22_RS01340	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
G8J22_RS01345	COG0248	Ppx GppA phosphatase
G8J22_RS01345	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
G8J22_RS01365	COG0517	IMP dehydrogenase activity
G8J22_RS01385	COG0559	Belongs to the binding-protein-dependent transport system permease family
G8J22_RS01395	COG1393	Belongs to the ArsC family
G8J22_RS01400	COG0436	Aminotransferase
G8J22_RS01410	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
G8J22_RS01415	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
G8J22_RS01425	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
G8J22_RS01475	COG0372	Belongs to the citrate synthase family
G8J22_RS01480	COG0538	isocitrate dehydrogenase activity
G8J22_RS01485	COG1045	serine acetyltransferase
G8J22_RS01490	COG0626	cystathionine gamma-synthase activity
G8J22_RS01495	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
G8J22_RS01515	COG1914	H( )-stimulated, divalent metal cation uptake system
G8J22_RS01525	COG2814	Major facilitator Superfamily
G8J22_RS01530	COG1012	belongs to the aldehyde dehydrogenase family
G8J22_RS01535	COG1597	lipid kinase activity
G8J22_RS01545	COG0004	ammonium transporteR
G8J22_RS01570	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
G8J22_RS01575	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
G8J22_RS01580	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
G8J22_RS01585	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
G8J22_RS01590	COG0047	phosphoribosylformylglycinamidine synthase activity
G8J22_RS01595	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
G8J22_RS01610	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
G8J22_RS01615	COG0138	bifunctional purine biosynthesis protein purh
G8J22_RS01620	COG0151	Belongs to the GarS family
G8J22_RS01640	COG2814	Major facilitator Superfamily
G8J22_RS01645	COG0284	orotidine-5'-phosphate decarboxylase activity
G8J22_RS01650	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
G8J22_RS01655	COG0167	dihydroorotate dehydrogenase activity
G8J22_RS01665	COG1482	cell wall glycoprotein biosynthetic process
G8J22_RS01690	COG2814	Major facilitator Superfamily
G8J22_RS01695	COG1113	amino acid transport
G8J22_RS01700	COG1522	sequence-specific DNA binding
G8J22_RS01730	COG2135	peptidase activity
G8J22_RS01745	COG0656	L-ascorbic acid biosynthetic process
G8J22_RS01770	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
G8J22_RS01800	COG3586	endonuclease activity
G8J22_RS01845	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
G8J22_RS01850	COG1696	Membrane protein involved in D-alanine export
G8J22_RS01855	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
G8J22_RS01860	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
G8J22_RS01875	COG0406	alpha-ribazole phosphatase activity
G8J22_RS01885	COG0095	Lipoate-protein ligase
G8J22_RS01890	COG1376	ErfK ybiS ycfS ynhG family protein
G8J22_RS01895	COG0509	glycine decarboxylation via glycine cleavage system
G8J22_RS01900	COG0656	L-ascorbic acid biosynthetic process
G8J22_RS01905	COG3428	Bacterial PH domain
G8J22_RS01915	COG2814	Major facilitator Superfamily
G8J22_RS01920	COG1846	Transcriptional regulator
G8J22_RS01925	COG1132	(ABC) transporter
G8J22_RS01930	COG1695	Transcriptional regulator
G8J22_RS01940	COG2197	response regulator
G8J22_RS01950	COG0842	Transport permease protein
G8J22_RS01955	COG1131	(ABC) transporter
G8J22_RS01985	COG0656	L-ascorbic acid biosynthetic process
G8J22_RS01990	COG1131	(ABC) transporter
G8J22_RS02020	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
G8J22_RS02025	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
G8J22_RS02040	COG1215	transferase activity, transferring glycosyl groups
G8J22_RS02045	COG1686	Belongs to the peptidase S11 family
G8J22_RS02075	COG0488	(ABC) transporter
G8J22_RS02085	COG0493	'glutamate synthase
G8J22_RS02090	COG0070	glutamate synthase
G8J22_RS02090	COG0069	glutamate synthase activity
G8J22_RS02090	COG0067	glutamate synthase
G8J22_RS02100	COG0719	Fe-S assembly protein
G8J22_RS02105	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
G8J22_RS02115	COG0719	Fe-S assembly protein
G8J22_RS02120	COG2151	metal-sulfur cluster biosynthetic enzyme
G8J22_RS02130	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
G8J22_RS02140	COG4989	oxidoreductase activity
G8J22_RS02145	COG0586	Pfam SNARE associated Golgi protein
G8J22_RS02150	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
G8J22_RS02155	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
G8J22_RS02160	COG2814	Major facilitator Superfamily
G8J22_RS02170	COG1902	pentaerythritol trinitrate reductase activity
G8J22_RS02175	COG1733	regulation of RNA biosynthetic process
G8J22_RS02190	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
G8J22_RS02210	COG2233	PERMEase
G8J22_RS02220	COG0583	DNA-binding transcription factor activity
G8J22_RS02230	COG1438	arginine binding
G8J22_RS02260	COG0546	phosphoglycolate phosphatase activity
G8J22_RS02275	COG2169	Transcriptional regulator
G8J22_RS02275	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
G8J22_RS02295	COG1418	mRNA catabolic process
G8J22_RS02310	COG1393	Belongs to the ArsC family
G8J22_RS02315	COG0561	phosphatase activity
G8J22_RS02330	COG0492	ferredoxin-NADP+ reductase activity
G8J22_RS02335	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
G8J22_RS02340	COG1368	sulfuric ester hydrolase activity
G8J22_RS02345	COG0406	alpha-ribazole phosphatase activity
G8J22_RS02380	COG0861	Integral membrane protein TerC family
G8J22_RS02385	COG3118	belongs to the thioredoxin family
G8J22_RS02400	COG1388	LysM domain
G8J22_RS02400	COG3942	CHAP domain
G8J22_RS02410	COG1132	(ABC) transporter
G8J22_RS02435	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
G8J22_RS02445	COG1609	Transcriptional regulator
G8J22_RS02455	COG0366	Alpha amylase catalytic
G8J22_RS02505	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
G8J22_RS02520	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
G8J22_RS02530	COG0300	oxidoreductase activity
G8J22_RS02535	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
G8J22_RS02540	COG0351	phosphomethylpyrimidine kinase
G8J22_RS02545	COG0352	thiamine-phosphate diphosphorylase activity
G8J22_RS02560	COG1120	ATPase activity
G8J22_RS02565	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
G8J22_RS02570	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
G8J22_RS02575	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
G8J22_RS02595	COG4166	transmembrane transport
G8J22_RS02625	COG0791	NLP P60 protein
G8J22_RS02625	COG1388	LysM domain
G8J22_RS02625	COG3103	Sh3 type 3 domain protein
G8J22_RS02640	COG4302	ethanolamine ammonia-lyase activity
G8J22_RS02645	COG4303	Ethanolamine ammonia lyase large subunit
G8J22_RS02650	COG4819	ethanolamine utilization protein
G8J22_RS02670	COG2814	Major facilitator Superfamily
G8J22_RS02735	COG4166	transmembrane transport
G8J22_RS02815	COG2223	nitrite transmembrane transporter activity
G8J22_RS02890	COG4166	transmembrane transport
G8J22_RS02900	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
G8J22_RS02910	COG4166	transmembrane transport
G8J22_RS02915	COG1309	transcriptional regulator
G8J22_RS02925	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
G8J22_RS02955	COG0366	Alpha amylase catalytic
G8J22_RS02965	COG1609	Transcriptional regulator
G8J22_RS03000	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
G8J22_RS03005	COG2801	Transposase and inactivated derivatives
G8J22_RS03010	COG2801	Transposase and inactivated derivatives
G8J22_RS03020	COG0738	Major facilitator superfamily
G8J22_RS03030	COG0710	3-dehydroquinate dehydratase activity
G8J22_RS03050	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
G8J22_RS03055	COG0738	Major facilitator superfamily
G8J22_RS03090	COG2807	transmembrane transport
G8J22_RS03105	COG1968	undecaprenyl-diphosphatase activity
G8J22_RS03120	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
G8J22_RS03130	COG1028	Short-chain dehydrogenase reductase Sdr
G8J22_RS03145	COG1028	Short-chain dehydrogenase reductase Sdr
G8J22_RS03155	COG4152	abc transporter atp-binding protein
G8J22_RS03160	COG1668	transmembrane transport
G8J22_RS03165	COG1725	Transcriptional regulator
G8J22_RS03240	COG0514	ATP-dependent DNA helicase (RecQ)
G8J22_RS03275	COG1126	abc transporter atp-binding protein
G8J22_RS03280	COG0765	amino acid transport
G8J22_RS03290	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G8J22_RS03305	COG0300	oxidoreductase activity
G8J22_RS03310	COG0300	oxidoreductase activity
G8J22_RS03320	COG1609	Transcriptional regulator
G8J22_RS03330	COG0366	Alpha amylase catalytic
G8J22_RS03420	COG1846	Transcriptional regulator
G8J22_RS03425	COG1393	Belongs to the ArsC family
G8J22_RS03430	COG2365	Tyrosine phosphatase family
G8J22_RS03470	COG1757	Na H antiporter
G8J22_RS03490	COG1125	glycine betaine transport
G8J22_RS03490	COG0517	IMP dehydrogenase activity
G8J22_RS03495	COG1174	glycine betaine transport
G8J22_RS03500	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
G8J22_RS03525	COG1113	amino acid transport
G8J22_RS03530	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
G8J22_RS03545	COG1929	Belongs to the glycerate kinase type-1 family
G8J22_RS03555	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
G8J22_RS03570	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
G8J22_RS03590	COG4166	transmembrane transport
G8J22_RS03595	COG4948	Mandelate Racemase Muconate Lactonizing
G8J22_RS03600	COG1053	succinate dehydrogenase
G8J22_RS03610	COG0174	glutamine synthetase
G8J22_RS03645	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
G8J22_RS03650	COG0066	3-isopropylmalate dehydratase activity
G8J22_RS03655	COG2271	Major facilitator Superfamily
G8J22_RS03690	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
G8J22_RS03705	COG1609	Transcriptional regulator
G8J22_RS03775	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
G8J22_RS03780	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
G8J22_RS03800	COG0357	Ribosomal RNA small subunit methyltransferase G
G8J22_RS03805	COG1192	Involved in chromosome partitioning
G8J22_RS03810	COG1475	DNA binding
G8J22_RS03815	COG4481	Protein conserved in bacteria
G8J22_RS03820	COG0012	GTP binding
G8J22_RS03830	COG0516	GMP reductase activity
G8J22_RS03830	COG0517	IMP dehydrogenase activity
G8J22_RS03860	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
G8J22_RS03865	COG0242	peptide deformylase activity
G8J22_RS03870	COG1247	-acetyltransferase
G8J22_RS03875	COG0745	RESPONSE REGULATOR receiver
G8J22_RS03885	COG1686	Belongs to the peptidase S11 family
G8J22_RS03920	COG0628	permease
G8J22_RS03925	COG0588	phosphoglycerate mutase activity
G8J22_RS03945	COG0519	Catalyzes the synthesis of GMP from XMP
G8J22_RS03965	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
G8J22_RS03995	COG0640	Transcriptional regulator
G8J22_RS04015	COG0667	Aldo Keto reductase
G8J22_RS04050	COG4975	Glucose uptake
G8J22_RS04060	COG0402	S-adenosylhomocysteine deaminase activity
G8J22_RS04065	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
G8J22_RS04105	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
G8J22_RS04120	COG1802	Transcriptional regulator
G8J22_RS04150	COG3250	beta-galactosidase activity
G8J22_RS04180	COG4166	transmembrane transport
G8J22_RS04225	COG2814	Major facilitator Superfamily
G8J22_RS04230	COG0667	Aldo Keto reductase
G8J22_RS04235	COG0589	response to stress
G8J22_RS04250	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
G8J22_RS04280	COG1686	Belongs to the peptidase S11 family
G8J22_RS04315	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
G8J22_RS04325	COG1272	protein, Hemolysin III
G8J22_RS04330	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
G8J22_RS04345	COG2814	Major facilitator Superfamily
G8J22_RS04350	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
G8J22_RS04360	COG0626	cystathionine gamma-synthase activity
G8J22_RS04380	COG2084	Dehydrogenase
G8J22_RS04390	COG0789	Transcriptional regulator
G8J22_RS04405	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
G8J22_RS04530	COG2217	Heavy metal translocating P-type atpase
G8J22_RS04540	COG1234	tRNA 3'-trailer cleavage
G8J22_RS04545	COG1393	Belongs to the ArsC family
G8J22_RS04550	COG4862	establishment of competence for transformation
G8J22_RS04555	COG0463	Glycosyl transferase, family 2
G8J22_RS04560	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
G8J22_RS04570	COG0745	RESPONSE REGULATOR receiver
G8J22_RS04575	COG5002	protein histidine kinase activity
G8J22_RS04580	COG1181	Belongs to the D-alanine--D-alanine ligase family
G8J22_RS04580	COG2918	glutathione biosynthetic process
G8J22_RS04600	COG2357	RelA SpoT domain protein
G8J22_RS04605	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
G8J22_RS04610	COG0564	pseudouridine synthase activity
G8J22_RS04615	COG0500	methyltransferase
G8J22_RS04625	COG1674	ftsk spoiiie
G8J22_RS04640	COG2001	Belongs to the MraZ family
G8J22_RS04645	COG0275	rRNA processing
G8J22_RS04655	COG0768	penicillin binding
G8J22_RS04660	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
G8J22_RS04670	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
G8J22_RS04675	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
G8J22_RS04690	COG1799	cell septum assembly
G8J22_RS04705	COG3599	regulation of cell shape
G8J22_RS04710	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
G8J22_RS04715	COG1278	Cold shock
G8J22_RS04720	COG0494	nUDIX hydrolase
G8J22_RS04730	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
G8J22_RS04735	COG1104	cysteine desulfurase activity
G8J22_RS04745	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
G8J22_RS04750	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
G8J22_RS04755	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
G8J22_RS04780	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
G8J22_RS04785	COG0107	imidazoleglycerol-phosphate synthase activity
G8J22_RS04790	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
G8J22_RS04800	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
G8J22_RS04805	COG0482	sulfurtransferase activity
G8J22_RS04825	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
G8J22_RS04830	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
G8J22_RS04835	COG0667	Aldo Keto reductase
G8J22_RS04840	COG1609	Transcriptional regulator
G8J22_RS04855	COG1397	ADP-ribosylglycohydrolase
G8J22_RS04860	COG1597	lipid kinase activity
G8J22_RS04870	COG5503	Protein of unknown function (DUF1447)
G8J22_RS04880	COG0242	peptide deformylase activity
G8J22_RS04910	COG0483	inositol monophosphate 1-phosphatase activity
G8J22_RS04915	COG1217	gtp-binding protein TYPA
G8J22_RS04920	COG0772	Belongs to the SEDS family
G8J22_RS04925	COG4471	UPF0298 protein
G8J22_RS04930	COG0742	ribosomal rna small subunit methyltransferase
G8J22_RS04935	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
G8J22_RS04940	COG3480	Lon protease (S16) C-terminal proteolytic domain
G8J22_RS04945	COG1555	photosystem II stabilization
G8J22_RS04950	COG2131	deaminase
G8J22_RS04955	COG0658	competence protein
G8J22_RS04955	COG2333	competence protein COMEC
G8J22_RS04960	COG1466	dna polymerase III delta subunit
G8J22_RS04965	COG0268	Binds directly to 16S ribosomal RNA
G8J22_RS04970	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
G8J22_RS04985	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
G8J22_RS04990	COG0544	peptidyl-prolyl cis-trans isomerase activity
G8J22_RS04995	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
G8J22_RS05000	COG0218	Necessary for normal cell division and for the maintenance of normal septation
G8J22_RS05010	COG0137	argininosuccinate synthase activity
G8J22_RS05025	COG0765	amino acid transport
G8J22_RS05040	COG0322	excinuclease ABC activity
G8J22_RS05045	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
G8J22_RS05050	COG2755	lipolytic protein G-D-S-L family
G8J22_RS05050	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
G8J22_RS05065	COG1234	tRNA 3'-trailer cleavage
G8J22_RS05075	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
G8J22_RS05075	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
G8J22_RS05080	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
G8J22_RS05090	COG0586	Pfam SNARE associated Golgi protein
G8J22_RS05095	COG0539	negative regulation of cytoplasmic translation
G8J22_RS05185	COG1126	abc transporter atp-binding protein
G8J22_RS05190	COG0765	amino acid transport
G8J22_RS05195	COG0436	Aminotransferase
G8J22_RS05210	COG0110	maltose O-acetyltransferase activity
G8J22_RS05215	COG3830	Belongs to the UPF0237 family
G8J22_RS05220	COG2848	UPF0210 protein
G8J22_RS05225	COG1472	Belongs to the glycosyl hydrolase 3 family
G8J22_RS05230	COG2153	protein acetylation
G8J22_RS05250	COG2409	Drug exporters of the RND superfamily
G8J22_RS05250	COG1033	growth of symbiont in host cell
G8J22_RS05270	COG1027	Aspartate ammonia-lyase
G8J22_RS05275	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
G8J22_RS05280	COG1846	Transcriptional regulator
G8J22_RS05285	COG0456	acetyltransferase
G8J22_RS05305	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
G8J22_RS05315	COG1012	belongs to the aldehyde dehydrogenase family
G8J22_RS05335	COG1902	pentaerythritol trinitrate reductase activity
G8J22_RS05340	COG0157	Belongs to the NadC ModD family
G8J22_RS05345	COG0477	Major facilitator Superfamily
G8J22_RS05350	COG0210	DNA helicase
G8J22_RS05350	COG0210	DNA helicase
G8J22_RS05365	COG1892	Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four- carbon dicarboxylic acid source for the tricarboxylic acid cycle
G8J22_RS05375	COG0569	domain protein
G8J22_RS05375	COG0475	glutathione-regulated potassium exporter activity
G8J22_RS05395	COG0028	Belongs to the TPP enzyme family
G8J22_RS05405	COG1028	Short-chain dehydrogenase reductase Sdr
G8J22_RS05415	COG0277	FAD linked oxidase domain protein
G8J22_RS05445	COG0028	Belongs to the TPP enzyme family
G8J22_RS05460	COG0025	NhaP-type Na H and K H
G8J22_RS05480	COG4932	domain protein
G8J22_RS05480	COG4886	Leucine-rich repeat (LRR) protein
G8J22_RS05500	COG0561	phosphatase activity
G8J22_RS05510	COG0745	RESPONSE REGULATOR receiver
G8J22_RS05515	COG5002	protein histidine kinase activity
G8J22_RS05515	COG3850	Histidine kinase
G8J22_RS05525	COG0436	Aminotransferase
G8J22_RS05565	COG1132	(ABC) transporter
G8J22_RS05575	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
G8J22_RS05580	COG3442	glutamine amidotransferase
G8J22_RS05585	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
G8J22_RS05590	COG1435	thymidine kinase activity
G8J22_RS05595	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
G8J22_RS05600	COG2890	protein-(glutamine-N5) methyltransferase activity
G8J22_RS05605	COG0009	L-threonylcarbamoyladenylate synthase
G8J22_RS05610	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
G8J22_RS05615	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
G8J22_RS05620	COG0356	it plays a direct role in the translocation of protons across the membrane
G8J22_RS05625	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
G8J22_RS05630	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
G8J22_RS05635	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
G8J22_RS05645	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
G8J22_RS05650	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
G8J22_RS05655	COG0355	proton-transporting ATP synthase activity, rotational mechanism
G8J22_RS05660	COG4836	Membrane
G8J22_RS05665	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
G8J22_RS05670	COG1077	Cell shape determining protein MreB Mrl
G8J22_RS05675	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
G8J22_RS05685	COG0772	Belongs to the SEDS family
G8J22_RS05690	COG0509	glycine decarboxylation via glycine cleavage system
G8J22_RS05695	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
G8J22_RS05700	COG2011	ABC-type metal ion transport system permease component
G8J22_RS05705	COG1464	Belongs to the NlpA lipoprotein family
G8J22_RS05715	COG1136	(ABC) transporter
G8J22_RS05725	COG1725	Transcriptional regulator
G8J22_RS05730	COG1131	(ABC) transporter
G8J22_RS05740	COG1181	Belongs to the D-alanine--D-alanine ligase family
G8J22_RS05750	COG2818	Glycosylase
G8J22_RS05770	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
G8J22_RS05775	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
G8J22_RS05780	COG1956	GAF domain-containing protein
G8J22_RS05785	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
G8J22_RS05790	COG1104	cysteine desulfurase activity
G8J22_RS05795	COG0301	tRNA thio-modification
G8J22_RS05805	COG0525	valine-tRNA ligase activity
G8J22_RS05810	COG0285	dihydrofolate synthase activity
G8J22_RS05815	COG1077	Cell shape determining protein MreB Mrl
G8J22_RS05820	COG1792	Involved in formation and maintenance of cell shape
G8J22_RS05825	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
G8J22_RS05830	COG0850	regulation of cytokinetic process
G8J22_RS05835	COG2894	cell division
G8J22_RS05840	COG0765	amino acid transport
G8J22_RS05845	COG1126	abc transporter atp-binding protein
G8J22_RS05850	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G8J22_RS05860	COG0612	Peptidase, M16
G8J22_RS05865	COG1426	Protein conserved in bacteria
G8J22_RS05870	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
G8J22_RS05875	COG1546	Belongs to the CinA family
G8J22_RS05875	COG1058	Belongs to the CinA family
G8J22_RS05880	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
G8J22_RS05885	COG1418	mRNA catabolic process
G8J22_RS05890	COG1692	metallophosphoesterase
G8J22_RS05895	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
G8J22_RS05900	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
G8J22_RS05905	COG0632	four-way junction helicase activity
G8J22_RS05910	COG2255	four-way junction helicase activity
G8J22_RS05915	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
G8J22_RS05920	COG0343	queuine tRNA-ribosyltransferase activity
G8J22_RS05925	COG1862	Preprotein translocase
G8J22_RS05930	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
G8J22_RS05935	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
G8J22_RS05940	COG0513	Belongs to the DEAD box helicase family
G8J22_RS05945	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
G8J22_RS05950	COG4472	Bacterial protein of unknown function (DUF965)
G8J22_RS05955	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
G8J22_RS05960	COG3906	Belongs to the UPF0473 family
G8J22_RS05975	COG1193	negative regulation of DNA recombination
G8J22_RS05980	COG3118	belongs to the thioredoxin family
G8J22_RS05985	COG1719	4-vinyl reductase, 4VR
G8J22_RS05990	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
G8J22_RS05995	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
G8J22_RS06010	COG0668	transmembrane transport
G8J22_RS06025	COG0006	proline dipeptidase activity
G8J22_RS06030	COG1609	Transcriptional regulator
G8J22_RS06035	COG0217	transcriptional regulatory protein
G8J22_RS06040	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
G8J22_RS06050	COG4537	Required for transformation and DNA binding
G8J22_RS06070	COG0827	DNA restriction-modification system
G8J22_RS06085	COG1113	amino acid transport
G8J22_RS06095	COG0737	Belongs to the 5'-nucleotidase family
G8J22_RS06100	COG4470	Protein conserved in bacteria
G8J22_RS06105	COG0647	UMP catabolic process
G8J22_RS06125	COG3425	synthase
G8J22_RS06130	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
G8J22_RS06135	COG4224	UPF0291 protein
G8J22_RS06140	COG3763	UPF0154 protein
G8J22_RS06145	COG0204	Acyl-transferase
G8J22_RS06150	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
G8J22_RS06155	COG2827	Endonuclease containing a URI domain
G8J22_RS06160	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
G8J22_RS06165	COG1011	Hydrolase
G8J22_RS06170	COG0052	Belongs to the universal ribosomal protein uS2 family
G8J22_RS06180	COG0528	UMP kinase activity
G8J22_RS06195	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
G8J22_RS06200	COG4589	Belongs to the CDS family
G8J22_RS06205	COG0750	zinc metalloprotease
G8J22_RS06210	COG0442	prolyl-tRNA aminoacylation
G8J22_RS06215	COG2176	DNA-directed DNA polymerase activity
G8J22_RS06225	COG0195	Participates in both transcription termination and antitermination
G8J22_RS06230	COG2740	Nucleic-acid-binding protein implicated in transcription termination
G8J22_RS06240	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
G8J22_RS06245	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
G8J22_RS06250	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
G8J22_RS06255	COG0196	riboflavin kinase activity
G8J22_RS06260	COG1420	regulation of RNA biosynthetic process
G8J22_RS06265	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
G8J22_RS06270	COG0443	Heat shock 70 kDa protein
G8J22_RS06275	COG0484	heat shock protein binding
G8J22_RS06280	COG0481	GTPase activity
G8J22_RS06285	COG0582	viral genome integration into host DNA
G8J22_RS06290	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
G8J22_RS06320	COG1396	sequence-specific DNA binding
G8J22_RS06350	COG1396	sequence-specific DNA binding
G8J22_RS06365	COG3561	AntA/AntB antirepressor
G8J22_RS06400	COG3935	DnaD domain protein
G8J22_RS06455	COG0756	dUTP diphosphatase activity
G8J22_RS06535	COG5492	domain, Protein
G8J22_RS06690	COG2264	protein methyltransferase activity
G8J22_RS06695	COG1385	rRNA (uridine-N3-)-methyltransferase activity
G8J22_RS06700	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
G8J22_RS06705	COG1490	D-aminoacyl-tRNA deacylase activity
G8J22_RS06715	COG3001	Fructosamine kinase
G8J22_RS06720	COG3103	Sh3 type 3 domain protein
G8J22_RS06720	COG0860	N-Acetylmuramoyl-L-alanine amidase
G8J22_RS06720	COG4991	sh3 domain protein
G8J22_RS06725	COG0124	histidyl-tRNA synthetase
G8J22_RS06730	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
G8J22_RS06735	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
G8J22_RS06740	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
G8J22_RS06745	COG1682	transport, permease protein
G8J22_RS06750	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
G8J22_RS06755	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
G8J22_RS06760	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
G8J22_RS06765	COG0828	Belongs to the bacterial ribosomal protein bS21 family
G8J22_RS06770	COG1610	YqeY-like protein
G8J22_RS06775	COG1702	phosphate starvation-inducible protein PhoH
G8J22_RS06780	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
G8J22_RS06785	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
G8J22_RS06790	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
G8J22_RS06795	COG1381	Involved in DNA repair and RecF pathway recombination
G8J22_RS06800	COG0752	glycyl-tRNA synthetase alpha subunit
G8J22_RS06805	COG0751	glycine-tRNA ligase activity
G8J22_RS06810	COG0358	DNA primase activity
G8J22_RS06815	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
G8J22_RS06820	COG2384	SAM-dependent methyltransferase
G8J22_RS06825	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
G8J22_RS06835	COG0542	response to heat
G8J22_RS06850	COG0587	DNA-directed DNA polymerase activity
G8J22_RS06860	COG2996	Protein conserved in bacteria
G8J22_RS06865	COG4974	Belongs to the 'phage' integrase family
G8J22_RS06875	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
G8J22_RS06880	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
G8J22_RS06885	COG1187	pseudouridine synthase activity
G8J22_RS06890	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
G8J22_RS06900	COG0514	ATP-dependent DNA helicase (RecQ)
G8J22_RS06910	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
G8J22_RS06915	COG0539	negative regulation of cytoplasmic translation
G8J22_RS06920	COG1160	GTP binding
G8J22_RS06935	COG0457	Tetratricopeptide repeat
G8J22_RS06940	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
G8J22_RS06945	COG0617	tRNA 3'-terminal CCA addition
G8J22_RS06950	COG0488	(ABC) transporter
G8J22_RS06955	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
G8J22_RS06960	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
G8J22_RS06965	COG1307	EDD domain protein, DegV family
G8J22_RS06970	COG2755	lipolytic protein G-D-S-L family
G8J22_RS06980	COG4479	Belongs to the UPF0346 family
G8J22_RS06990	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
G8J22_RS06995	COG0758	DNA mediated transformation
G8J22_RS07000	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
G8J22_RS07015	COG1942	4-Oxalocrotonate Tautomerase
G8J22_RS07025	COG0561	phosphatase activity
G8J22_RS07030	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
G8J22_RS07030	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
G8J22_RS07035	COG3022	response to hydroperoxide
G8J22_RS07040	COG1304	FMN binding
G8J22_RS07060	COG1199	ATP-dependent helicase activity
G8J22_RS07060	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
G8J22_RS07070	COG0436	Aminotransferase
G8J22_RS07075	COG0017	Asparaginyl-tRNA synthetase
G8J22_RS07090	COG3331	DNA recombination
G8J22_RS07095	COG4474	Belongs to the UPF0398 family
G8J22_RS07100	COG3599	regulation of cell shape
G8J22_RS07110	COG0116	Belongs to the methyltransferase superfamily
G8J22_RS07120	COG0328	RNA-DNA hybrid ribonuclease activity
G8J22_RS07130	COG2759	Belongs to the formate--tetrahydrofolate ligase family
G8J22_RS07135	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
G8J22_RS07140	COG0564	pseudouridine synthase activity
G8J22_RS07145	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
G8J22_RS07150	COG0505	Belongs to the CarA family
G8J22_RS07155	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
G8J22_RS07160	COG1293	RNA-binding protein homologous to eukaryotic snRNP
G8J22_RS07170	COG1307	EDD domain protein, DegV family
G8J22_RS07175	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
G8J22_RS07185	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
G8J22_RS07185	COG0302	gtp cyclohydrolase
G8J22_RS07200	COG1051	belongs to the nudix hydrolase family
G8J22_RS07215	COG1063	alcohol dehydrogenase
G8J22_RS07220	COG3475	LICD family
G8J22_RS07230	COG4974	Belongs to the 'phage' integrase family
G8J22_RS07235	COG1194	a g-specific adenine glycosylase
G8J22_RS07290	COG3655	Transcriptional regulator
G8J22_RS07300	COG0028	Belongs to the TPP enzyme family
G8J22_RS07305	COG2261	transglycosylase associated protein
G8J22_RS07325	COG0745	RESPONSE REGULATOR receiver
G8J22_RS07330	COG3850	Histidine kinase
G8J22_RS07330	COG5002	protein histidine kinase activity
G8J22_RS07340	COG0789	Transcriptional regulator
G8J22_RS07345	COG0463	Glycosyl transferase, family 2
G8J22_RS07350	COG0671	phosphoesterase, PA-phosphatase related
G8J22_RS07355	COG4485	Bacterial membrane protein, YfhO
G8J22_RS07375	COG0456	acetyltransferase
G8J22_RS07395	COG0640	Transcriptional regulator
G8J22_RS07400	COG2217	Heavy metal translocating P-type atpase
G8J22_RS07415	COG1609	Transcriptional regulator
G8J22_RS07425	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
G8J22_RS07430	COG1028	Short-chain dehydrogenase reductase Sdr
G8J22_RS07480	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
G8J22_RS07485	COG1227	inorganic diphosphatase activity
G8J22_RS07490	COG0583	DNA-binding transcription factor activity
G8J22_RS07500	COG0187	DNA topoisomerase II activity
G8J22_RS07505	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
G8J22_RS07515	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
G8J22_RS07520	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
G8J22_RS07525	COG4974	Belongs to the 'phage' integrase family
G8J22_RS07530	COG0335	large ribosomal subunit rRNA binding
G8J22_RS07535	COG0336	Belongs to the RNA methyltransferase TrmD family
G8J22_RS07540	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
G8J22_RS07545	COG1837	Belongs to the UPF0109 family
G8J22_RS07550	COG0228	four-way junction DNA binding
G8J22_RS07555	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
G8J22_RS07560	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
G8J22_RS07565	COG0552	protein localization to endoplasmic reticulum
G8J22_RS07570	COG1196	nuclear chromosome segregation
G8J22_RS07575	COG0571	ribonuclease III activity
G8J22_RS07580	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
G8J22_RS07585	COG0416	fatty acid biosynthetic process
G8J22_RS07590	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
G8J22_RS07600	COG1302	Protein conserved in bacteria
G8J22_RS07605	COG0227	Belongs to the bacterial ribosomal protein bL28 family
G8J22_RS07615	COG1564	THIamine pyrophosphokinase
G8J22_RS07620	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
G8J22_RS07625	COG1162	GTPase activity
G8J22_RS07630	COG2815	serine threonine protein kinase
G8J22_RS07630	COG0515	serine threonine protein kinase
G8J22_RS07635	COG0631	protein serine/threonine phosphatase activity
G8J22_RS07640	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
G8J22_RS07640	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
G8J22_RS07645	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
G8J22_RS07650	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
G8J22_RS07655	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
G8J22_RS07660	COG1758	RNA polymerase activity
G8J22_RS07665	COG0194	GDP metabolic process
G8J22_RS07675	COG0497	DNA recombination
G8J22_RS07680	COG1438	arginine binding
G8J22_RS07685	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
G8J22_RS07695	COG1722	exodeoxyribonuclease VII activity
G8J22_RS07700	COG1570	exodeoxyribonuclease VII activity
G8J22_RS07705	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
G8J22_RS07710	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
G8J22_RS07715	COG1302	Protein conserved in bacteria
G8J22_RS07720	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
G8J22_RS07725	COG0211	Belongs to the bacterial ribosomal protein bL27 family
G8J22_RS07735	COG0261	This protein binds to 23S rRNA in the presence of protein L20
G8J22_RS07770	COG0789	Transcriptional regulator
G8J22_RS07775	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
G8J22_RS07780	COG0584	glycerophosphoryl diester phosphodiesterase
G8J22_RS07790	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
G8J22_RS07795	COG1940	carbohydrate kinase activity
G8J22_RS07805	COG0457	Tetratricopeptide repeat
G8J22_RS07805	COG0705	Rhomboid family
G8J22_RS07810	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
G8J22_RS07815	COG0267	Belongs to the bacterial ribosomal protein bL33 family
G8J22_RS07820	COG0768	penicillin binding
G8J22_RS07830	COG4841	protein insertion into membrane
G8J22_RS07835	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
G8J22_RS07840	COG0572	uridine kinase
G8J22_RS07845	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
G8J22_RS07850	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
G8J22_RS07850	COG0072	phenylalanine-tRNA ligase activity
G8J22_RS07855	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
G8J22_RS07860	COG1733	regulation of RNA biosynthetic process
G8J22_RS07870	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
G8J22_RS07875	COG1254	Belongs to the acylphosphatase family
G8J22_RS07880	COG0706	membrane insertase activity
G8J22_RS07885	COG5002	protein histidine kinase activity
G8J22_RS07890	COG0745	RESPONSE REGULATOR receiver
G8J22_RS07895	COG1064	alcohol dehydrogenase
G8J22_RS07910	COG1323	Belongs to the UPF0348 family
G8J22_RS07915	COG2226	methyltransferase
G8J22_RS07920	COG0799	negative regulation of ribosome biogenesis
G8J22_RS07925	COG1713	HD superfamily hydrolase involved in NAD metabolism
G8J22_RS07930	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
G8J22_RS07935	COG1534	Rna-binding protein
G8J22_RS07940	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
G8J22_RS07945	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
G8J22_RS07950	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
G8J22_RS07955	COG0291	Belongs to the bacterial ribosomal protein bL35 family
G8J22_RS07960	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
G8J22_RS07965	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
G8J22_RS07970	COG1484	DNA-dependent DNA replication
G8J22_RS07980	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
G8J22_RS07985	COG0237	dephospho-CoA kinase activity
G8J22_RS07990	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
G8J22_RS08000	COG0670	Belongs to the BI1 family
G8J22_RS08005	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
G8J22_RS08010	COG1674	ftsk spoiiie
G8J22_RS08015	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
G8J22_RS08020	COG3118	belongs to the thioredoxin family
G8J22_RS08030	COG0220	tRNA (guanine-N7-)-methyltransferase activity
G8J22_RS08040	COG1131	(ABC) transporter
G8J22_RS08045	COG0537	adenosine 5'-monophosphoramidase activity
G8J22_RS08055	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
G8J22_RS08065	COG4717	serine-type aminopeptidase activity
G8J22_RS08070	COG0420	3'-5' exonuclease activity
G8J22_RS08075	COG3679	Belongs to the UPF0342 family
G8J22_RS08080	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
G8J22_RS08085	COG0018	arginyl-trna synthetase
G8J22_RS08100	COG1794	racemase activity, acting on amino acids and derivatives
G8J22_RS08115	COG0367	asparagine synthase
G8J22_RS08145	COG1846	Transcriptional regulator
G8J22_RS08165	COG0791	NLP P60 protein
G8J22_RS08175	COG4948	Mandelate Racemase Muconate Lactonizing
G8J22_RS08180	COG4166	transmembrane transport
G8J22_RS08215	COG1554	hydrolase, family 65, central catalytic
G8J22_RS08220	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
G8J22_RS08225	COG0561	phosphatase activity
G8J22_RS08230	COG1428	Deoxynucleoside kinase
G8J22_RS08240	COG0589	response to stress
G8J22_RS08245	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
G8J22_RS08250	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
G8J22_RS08255	COG2244	polysaccharide biosynthetic process
G8J22_RS08265	COG0495	leucyl-tRNA aminoacylation
G8J22_RS08270	COG0671	phosphoesterase, PA-phosphatase related
G8J22_RS08275	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
G8J22_RS08280	COG0477	Major facilitator Superfamily
G8J22_RS08285	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
G8J22_RS08305	COG1113	amino acid transport
G8J22_RS08310	COG1335	isochorismatase
G8J22_RS08325	COG1302	Protein conserved in bacteria
G8J22_RS08340	COG2261	transglycosylase associated protein
G8J22_RS08355	COG3475	LICD family
G8J22_RS08380	COG1134	teichoic acid transport
G8J22_RS08385	COG1388	LysM domain
G8J22_RS08385	COG1705	Flagellar rod assembly protein muramidase FlgJ
G8J22_RS08390	COG1388	LysM domain
G8J22_RS08390	COG1705	Flagellar rod assembly protein muramidase FlgJ
G8J22_RS08395	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
G8J22_RS08400	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
G8J22_RS08405	COG4856	YbbR-like protein
G8J22_RS08410	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
G8J22_RS08420	COG0025	NhaP-type Na H and K H
G8J22_RS08425	COG0812	UDP-N-acetylmuramate dehydrogenase activity
G8J22_RS08430	COG2176	DNA-directed DNA polymerase activity
G8J22_RS08435	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
G8J22_RS08440	COG0802	atpase or kinase
G8J22_RS08445	COG0280	phosphate acetyltransferase
G8J22_RS08450	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
G8J22_RS08460	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
G8J22_RS08465	COG0557	exoribonuclease II activity
G8J22_RS08475	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
G8J22_RS08490	COG0148	phosphopyruvate hydratase activity
G8J22_RS08495	COG0149	triose-phosphate isomerase activity
G8J22_RS08515	COG0346	lactoylglutathione lyase activity
G8J22_RS08520	COG0740	serine-type endopeptidase activity
G8J22_RS08530	COG1481	regulation of sporulation
G8J22_RS08540	COG1660	Displays ATPase and GTPase activities
G8J22_RS08545	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
G8J22_RS08550	COG0556	nucleotide-excision repair
G8J22_RS08560	COG0492	ferredoxin-NADP+ reductase activity
G8J22_RS08565	COG1210	Utp--glucose-1-phosphate uridylyltransferase
G8J22_RS08570	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
G8J22_RS08575	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
G8J22_RS08580	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
G8J22_RS08585	COG1950	PFAM Membrane protein of
G8J22_RS08590	COG1983	PspC domain protein
G8J22_RS08595	COG0704	Plays a role in the regulation of phosphate uptake
G8J22_RS08600	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
G8J22_RS08605	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
G8J22_RS08610	COG0581	inorganic phosphate transmembrane transporter activity
G8J22_RS08615	COG0573	inorganic phosphate transmembrane transporter activity
G8J22_RS08625	COG5002	protein histidine kinase activity
G8J22_RS08630	COG0745	RESPONSE REGULATOR receiver
G8J22_RS08645	COG0653	protein targeting
G8J22_RS08660	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
G8J22_RS08665	COG1739	Uncharacterized protein family UPF0029
G8J22_RS08670	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
G8J22_RS08675	COG2223	nitrite transmembrane transporter activity
G8J22_RS08690	COG0531	amino acid
G8J22_RS08695	COG0459	protein refolding
G8J22_RS08700	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
G8J22_RS08705	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
G8J22_RS08710	COG0488	(ABC) transporter
G8J22_RS08715	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
G8J22_RS08725	COG1214	PFAM Peptidase M22, glycoprotease
G8J22_RS08735	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
G8J22_RS08740	COG4467	Involved in initiation control of chromosome replication
G8J22_RS08745	COG0470	DNA polymerase III
G8J22_RS08750	COG3870	Protein conserved in bacteria
G8J22_RS08755	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
G8J22_RS08765	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
G8J22_RS08770	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
G8J22_RS08775	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
G8J22_RS08790	COG2813	Specifically methylates the guanine in position
G8J22_RS08795	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
G8J22_RS08800	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
G8J22_RS08815	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
G8J22_RS08820	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
G8J22_RS08825	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
G8J22_RS08830	COG2855	membrane
G8J22_RS08835	COG0583	DNA-binding transcription factor activity
G8J22_RS08845	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
G8J22_RS08845	COG0392	lysyltransferase activity
G8J22_RS08855	COG0222	ribosome binding
G8J22_RS08860	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
G8J22_RS08865	COG0081	regulation of translation
G8J22_RS08870	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
G8J22_RS08880	COG0250	Participates in transcription elongation, termination and antitermination
G8J22_RS08885	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
G8J22_RS08890	COG0267	Belongs to the bacterial ribosomal protein bL33 family
G8J22_RS08905	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
G8J22_RS08910	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
G8J22_RS08915	COG0215	cysteine-tRNA ligase activity
G8J22_RS08920	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
G8J22_RS08925	COG4956	integral membrane protein (PIN domain superfamily)
G8J22_RS08930	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
G8J22_RS08935	COG0756	dUTP diphosphatase activity
G8J22_RS08940	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
G8J22_RS08950	COG0588	phosphoglycerate mutase activity
G8J22_RS08955	COG0697	spore germination
G8J22_RS08965	COG1316	TRANSCRIPTIONal
G8J22_RS08970	COG3716	PTS system mannose fructose sorbose family IID component
G8J22_RS08975	COG3715	PTS system
G8J22_RS08985	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
G8J22_RS08985	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
G8J22_RS08990	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
G8J22_RS09000	COG0083	homoserine kinase activity
G8J22_RS09005	COG3091	SprT-like family
G8J22_RS09010	COG2183	response to ionizing radiation
G8J22_RS09030	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
G8J22_RS09040	COG2188	Transcriptional regulator
G8J22_RS09050	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
G8J22_RS09085	COG3104	oligopeptide transport
G8J22_RS09135	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
G8J22_RS09140	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
G8J22_RS09145	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
G8J22_RS09160	COG0037	tRNA processing
G8J22_RS09165	COG1098	S1 RNA binding domain
G8J22_RS09175	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
G8J22_RS09180	COG2244	polysaccharide biosynthetic process
G8J22_RS09185	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
G8J22_RS09190	COG0193	aminoacyl-tRNA hydrolase activity
G8J22_RS09195	COG0039	L-malate dehydrogenase activity
G8J22_RS09205	COG2337	Toxic component of a toxin-antitoxin (TA) module
G8J22_RS09215	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
G8J22_RS09220	COG0736	holo-[acyl-carrier-protein] synthase activity
G8J22_RS09230	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
G8J22_RS09240	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
G8J22_RS09245	COG3764	Sortase (surface protein transpeptidase)
G8J22_RS09255	COG0254	rRNA binding
G8J22_RS09260	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
G8J22_RS09265	COG0504	CTP synthase activity
G8J22_RS09270	COG3343	RNA polymerase activity
G8J22_RS09280	COG0095	Lipoate-protein ligase
G8J22_RS09285	COG1078	dGTPase activity
G8J22_RS09290	COG0561	phosphatase activity
G8J22_RS09300	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
G8J22_RS09305	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
G8J22_RS09310	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
G8J22_RS09315	COG1108	ABC-type Mn2 Zn2 transport systems permease components
G8J22_RS09320	COG1121	(ABC) transporter
G8J22_RS09325	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
G8J22_RS09330	COG4466	Protein conserved in bacteria
G8J22_RS09335	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
G8J22_RS09340	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
G8J22_RS09345	COG0084	hydrolase, TatD family'
G8J22_RS09350	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
G8J22_RS09350	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
G8J22_RS09355	COG1801	Protein of unknown function DUF72
G8J22_RS09360	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
G8J22_RS09375	COG0248	Ppx GppA phosphatase
G8J22_RS09385	COG3973	AAA domain
G8J22_RS09405	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
G8J22_RS09410	COG4988	ABC transporter
G8J22_RS09415	COG1294	oxidase, subunit
G8J22_RS09420	COG1271	oxidase subunit
G8J22_RS09425	COG1252	NADH dehydrogenase
G8J22_RS09470	COG1368	sulfuric ester hydrolase activity
G8J22_RS09480	COG0438	transferase activity, transferring glycosyl groups
G8J22_RS09485	COG0438	transferase activity, transferring glycosyl groups
G8J22_RS09495	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
G8J22_RS09505	COG0542	response to heat
G8J22_RS09525	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
G8J22_RS09535	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
G8J22_RS09540	COG0628	permease
G8J22_RS09545	COG3557	Belongs to the UPF0374 family
G8J22_RS09550	COG2137	regulation of response to DNA damage stimulus
G8J22_RS09555	COG0716	FMN binding
G8J22_RS09560	COG1295	ribonuclease BN
G8J22_RS09565	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
G8J22_RS09570	COG0463	Glycosyl transferase, family 2
G8J22_RS09575	COG2246	polysaccharide biosynthetic process
G8J22_RS09595	COG0673	inositol 2-dehydrogenase activity
G8J22_RS09605	COG3409	Peptidoglycan-binding domain 1 protein
G8J22_RS09605	COG3757	hydrolase, family 25
G8J22_RS09610	COG1737	Transcriptional regulator
G8J22_RS09615	COG1070	Carbohydrate kinase
G8J22_RS09625	COG1268	BioY protein
G8J22_RS09635	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
G8J22_RS09640	COG0825	malonyl-CoA metabolic process
G8J22_RS09645	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
G8J22_RS09650	COG0439	Biotin carboxylase
G8J22_RS09655	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
G8J22_RS09660	COG0511	ligase activity, forming carbon-carbon bonds
G8J22_RS09670	COG1028	Short-chain dehydrogenase reductase Sdr
G8J22_RS09675	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
G8J22_RS09685	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
G8J22_RS09695	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
G8J22_RS09700	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
G8J22_RS09705	COG2390	Transcriptional regulator
G8J22_RS09710	COG0813	purine-nucleoside phosphorylase activity
G8J22_RS09715	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
G8J22_RS09720	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
G8J22_RS09740	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
G8J22_RS09745	COG1597	lipid kinase activity
G8J22_RS09750	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
G8J22_RS09755	COG0154	amidase activity
G8J22_RS09760	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
G8J22_RS09765	COG4851	CamS sex pheromone cAM373 precursor
G8J22_RS09770	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
G8J22_RS09775	COG0110	maltose O-acetyltransferase activity
G8J22_RS09785	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
G8J22_RS09790	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
G8J22_RS09795	COG1705	Flagellar rod assembly protein muramidase FlgJ
G8J22_RS09810	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
G8J22_RS09815	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
G8J22_RS09820	COG0101	tRNA pseudouridine synthase activity
G8J22_RS09825	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
G8J22_RS09830	COG1122	ATPase activity
G8J22_RS09840	COG0203	ribosomal protein L17
G8J22_RS09845	COG0202	RNA polymerase activity
G8J22_RS09850	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
G8J22_RS09855	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
G8J22_RS09860	COG0257	Belongs to the bacterial ribosomal protein bL36 family
G8J22_RS09865	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
G8J22_RS09880	COG0200	Binds to the 23S rRNA
G8J22_RS09890	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
G8J22_RS09895	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
G8J22_RS09900	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
G8J22_RS09905	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
G8J22_RS09910	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
G8J22_RS09915	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
G8J22_RS09920	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
G8J22_RS09925	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
G8J22_RS09935	COG0255	Belongs to the universal ribosomal protein uL29 family
G8J22_RS09940	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
G8J22_RS09945	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
G8J22_RS09950	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
G8J22_RS09960	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
G8J22_RS09965	COG0089	rRNA binding
G8J22_RS09970	COG0088	Forms part of the polypeptide exit tunnel
G8J22_RS09975	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
G8J22_RS09980	COG0051	transcription antitermination factor activity, RNA binding
G8J22_RS09985	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
G8J22_RS09990	COG0049	tRNA binding
G8J22_RS09995	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
G8J22_RS10000	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
G8J22_RS10005	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
G8J22_RS10010	COG0085	RNA polymerase activity
G8J22_RS10015	COG0542	response to heat
G8J22_RS10020	COG4463	regulation of RNA biosynthetic process
G8J22_RS10065	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
G8J22_RS10070	COG1428	Deoxynucleoside kinase
G8J22_RS10075	COG3684	Belongs to the aldolase LacD family
G8J22_RS10080	COG0833	amino acid
G8J22_RS10120	COG1321	iron dependent repressor
G8J22_RS10145	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
G8J22_RS10180	COG0564	pseudouridine synthase activity
G8J22_RS10205	COG0393	Putative heavy-metal-binding
G8J22_RS10210	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
G8J22_RS10215	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
G8J22_RS10220	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
G8J22_RS10225	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
G8J22_RS10230	COG2873	o-acetylhomoserine
G8J22_RS10235	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
G8J22_RS10250	COG1473	amidohydrolase
G8J22_RS10295	COG4221	oxidoreductase activity
G8J22_RS10300	COG0789	Transcriptional regulator
G8J22_RS10310	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
G8J22_RS10315	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
G8J22_RS10330	COG2814	Major facilitator Superfamily
G8J22_RS10340	COG0708	Exodeoxyribonuclease III
G8J22_RS10345	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
G8J22_RS10365	COG0534	Mate efflux family protein
G8J22_RS10380	COG0308	aminopeptidase N
G8J22_RS10385	COG0519	Catalyzes the synthesis of GMP from XMP
G8J22_RS10385	COG0518	GMP synthase (glutamine-hydrolyzing) activity
G8J22_RS10390	COG1072	(Pantothenic acid kinase))
G8J22_RS10395	COG3973	AAA domain
G8J22_RS10400	COG0588	phosphoglycerate mutase activity
G8J22_RS10405	COG4608	Belongs to the ABC transporter superfamily
G8J22_RS10410	COG0444	Belongs to the ABC transporter superfamily
G8J22_RS10415	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G8J22_RS10420	COG0601	transmembrane transport
G8J22_RS10430	COG4166	transmembrane transport
G8J22_RS10440	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
G8J22_RS10445	COG0531	amino acid
G8J22_RS10450	COG1285	pathogenesis
G8J22_RS10455	COG0765	amino acid transport
G8J22_RS10460	COG0765	amino acid transport
G8J22_RS10465	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G8J22_RS10470	COG1126	abc transporter atp-binding protein
G8J22_RS10485	COG0735	belongs to the Fur family
G8J22_RS10510	COG1278	Cold shock
G8J22_RS10515	COG2936	dipeptidyl-peptidase activity
G8J22_RS10520	COG2267	carboxylic ester hydrolase activity
G8J22_RS10545	COG2814	Major facilitator Superfamily
G8J22_RS10555	COG0366	Alpha amylase catalytic
G8J22_RS10570	COG0488	(ABC) transporter
G8J22_RS10675	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
G8J22_RS10685	COG0395	ABC-type sugar transport system, permease component
G8J22_RS10695	COG3842	ATPase activity
G8J22_RS10715	COG2084	Dehydrogenase
G8J22_RS10740	COG1228	amidohydrolase
G8J22_RS10745	COG1177	transmembrane transport
G8J22_RS10750	COG1176	ABC-type spermidine putrescine transport system, permease component I
G8J22_RS10755	COG3842	ATPase activity
G8J22_RS10770	COG2197	response regulator
G8J22_RS10790	COG1518	maintenance of DNA repeat elements
G8J22_RS10830	COG0419	ATPase involved in DNA repair
G8J22_RS10835	COG0420	3'-5' exonuclease activity
G8J22_RS10860	COG2515	1-aminocyclopropane-1-carboxylate deaminase
G8J22_RS10865	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G8J22_RS10875	COG4120	Belongs to the binding-protein-dependent transport system permease family
G8J22_RS10880	COG1122	ATPase activity
G8J22_RS10890	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
G8J22_RS10900	COG1288	antiporter activity
G8J22_RS10910	COG1846	Transcriptional regulator
G8J22_RS10915	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
G8J22_RS10915	COG0574	Belongs to the PEP-utilizing enzyme family
G8J22_RS10920	COG0517	IMP dehydrogenase activity
G8J22_RS10930	COG0456	acetyltransferase
G8J22_RS10945	COG2153	protein acetylation
G8J22_RS10955	COG1881	PFAM PEBP family protein
G8J22_RS10960	COG0589	response to stress
G8J22_RS10965	COG0446	pyridine nucleotide-disulphide oxidoreductase
G8J22_RS10970	COG0531	amino acid
G8J22_RS10975	COG0531	amino acid
G8J22_RS11010	COG1388	LysM domain
G8J22_RS11010	COG3942	CHAP domain
G8J22_RS11020	COG4684	Psort location CytoplasmicMembrane, score
G8J22_RS11025	COG1725	Transcriptional regulator
G8J22_RS11035	COG0514	ATP-dependent DNA helicase (RecQ)
G8J22_RS11080	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
G8J22_RS11100	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
G8J22_RS11115	COG1122	ATPase activity
G8J22_RS11135	COG0702	epimerase
G8J22_RS11175	COG1177	transmembrane transport
G8J22_RS11190	COG2814	Major facilitator Superfamily
G8J22_RS11195	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
G8J22_RS11200	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
G8J22_RS11205	COG0436	Aminotransferase
G8J22_RS11210	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
G8J22_RS11215	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
G8J22_RS11220	COG1473	amidohydrolase
G8J22_RS11225	COG2171	N-acyltransferase activity
G8J22_RS11230	COG0019	diaminopimelate decarboxylase activity
G8J22_RS11235	COG0527	aspartate kinase activity
G8J22_RS11240	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
G8J22_RS11260	COG0179	Fumarylacetoacetate (FAA) hydrolase
G8J22_RS11265	COG2706	6-phosphogluconolactonase activity
G8J22_RS11275	COG0735	belongs to the Fur family
G8J22_RS11290	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
G8J22_RS11305	COG0589	response to stress
G8J22_RS11310	COG1028	Short-chain dehydrogenase reductase Sdr
G8J22_RS11320	COG1063	alcohol dehydrogenase
G8J22_RS11340	COG1396	sequence-specific DNA binding
G8J22_RS11360	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
G8J22_RS11380	COG3590	peptidase
G8J22_RS11395	COG0024	Methionine aminopeptidase
G8J22_RS11400	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
G8J22_RS11405	COG2094	Belongs to the DNA glycosylase MPG family
G8J22_RS11410	COG3189	MarR family transcriptional regulator
G8J22_RS11415	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
G8J22_RS11425	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
G8J22_RS11430	COG0328	RNA-DNA hybrid ribonuclease activity
G8J22_RS11440	COG0402	S-adenosylhomocysteine deaminase activity
G8J22_RS11445	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
G8J22_RS11450	COG0569	domain protein
G8J22_RS11460	COG0351	phosphomethylpyrimidine kinase
G8J22_RS11480	COG2249	NAD(P)H dehydrogenase (quinone) activity
G8J22_RS11490	COG0542	response to heat
G8J22_RS11495	COG1278	Cold shock
G8J22_RS11510	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
G8J22_RS11530	COG1119	ATPase activity
G8J22_RS11535	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
G8J22_RS11540	COG0028	Belongs to the TPP enzyme family
G8J22_RS11560	COG0129	dihydroxy-acid dehydratase activity
G8J22_RS11565	COG0385	Bile acid
G8J22_RS11570	COG0095	Lipoate-protein ligase
G8J22_RS11740	COG5484	DNA packaging
G8J22_RS11745	COG0756	dUTP diphosphatase activity
G8J22_RS11780	COG2826	transposase and inactivated derivatives, IS30 family
G8J22_RS11905	COG1396	sequence-specific DNA binding
G8J22_RS11950	COG0509	glycine decarboxylation via glycine cleavage system
G8J22_RS11975	COG1609	Transcriptional regulator
G8J22_RS11980	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
G8J22_RS12020	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
G8J22_RS12035	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
G8J22_RS12050	COG1307	EDD domain protein, DegV family
G8J22_RS12055	COG0477	Major facilitator Superfamily
G8J22_RS12110	COG1131	(ABC) transporter
G8J22_RS12140	COG5658	integral membrane protein
G8J22_RS12175	COG0488	(ABC) transporter
G8J22_RS12180	COG0588	phosphoglycerate mutase activity
G8J22_RS12190	COG0656	L-ascorbic acid biosynthetic process
G8J22_RS12195	COG0110	maltose O-acetyltransferase activity
G8J22_RS12210	COG1609	Transcriptional regulator
G8J22_RS12215	COG2017	converts alpha-aldose to the beta-anomer
G8J22_RS12220	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G8J22_RS12225	COG0765	amino acid transport
G8J22_RS12235	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
G8J22_RS12245	COG1802	Transcriptional regulator
G8J22_RS12255	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
G8J22_RS12270	COG3103	Sh3 type 3 domain protein
G8J22_RS12270	COG0791	NLP P60 protein
G8J22_RS12270	COG1388	LysM domain
G8J22_RS12290	COG0531	amino acid
G8J22_RS12300	COG5002	protein histidine kinase activity
G8J22_RS12310	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
G8J22_RS12310	COG4221	oxidoreductase activity
G8J22_RS12310	COG3321	synthase
G8J22_RS12310	COG0604	alcohol dehydrogenase
G8J22_RS12325	COG0095	Lipoate-protein ligase
G8J22_RS12335	COG0564	pseudouridine synthase activity
G8J22_RS12345	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
G8J22_RS12350	COG2188	Transcriptional regulator
G8J22_RS12355	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
G8J22_RS12365	COG1418	mRNA catabolic process
G8J22_RS12370	COG1454	alcohol dehydrogenase
G8J22_RS12370	COG1012	belongs to the aldehyde dehydrogenase family
G8J22_RS12380	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
G8J22_RS12385	COG0656	L-ascorbic acid biosynthetic process
G8J22_RS12395	COG1253	flavin adenine dinucleotide binding
G8J22_RS12405	COG1780	Probably involved in ribonucleotide reductase function
G8J22_RS12410	COG2814	Major facilitator Superfamily
G8J22_RS12425	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
G8J22_RS12430	COG0352	thiamine-phosphate diphosphorylase activity
G8J22_RS12440	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
G8J22_RS12445	COG2022	thiamine diphosphate biosynthetic process
G8J22_RS12450	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
G8J22_RS12500	COG0183	Belongs to the thiolase family
G8J22_RS12525	COG3328	transposase activity
G8J22_RS12530	COG0626	cystathionine gamma-synthase activity
G8J22_RS12535	COG1376	ErfK ybiS ycfS ynhG family protein
G8J22_RS12540	COG1074	ATP-dependent DNA helicase activity
G8J22_RS12545	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
G8J22_RS12560	COG0667	Aldo Keto reductase
G8J22_RS12565	COG1733	regulation of RNA biosynthetic process
G8J22_RS12580	COG0693	protein deglycase activity
G8J22_RS12585	COG2252	PERMEase
G8J22_RS12590	COG4708	membrane
G8J22_RS12600	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
G8J22_RS12620	COG0477	Major facilitator Superfamily
G8J22_RS12625	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
G8J22_RS12640	COG1307	EDD domain protein, DegV family
G8J22_RS12645	COG1695	Transcriptional regulator
G8J22_RS12650	COG0477	Major facilitator Superfamily
G8J22_RS12685	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
G8J22_RS12690	COG4975	Glucose uptake
G8J22_RS12730	COG0159	tryptophan synthase activity
G8J22_RS12745	COG2244	polysaccharide biosynthetic process
G8J22_RS12755	COG0477	Major facilitator Superfamily
G8J22_RS12770	COG4152	abc transporter atp-binding protein
G8J22_RS12790	COG1733	regulation of RNA biosynthetic process
G8J22_RS12805	COG1131	(ABC) transporter
G8J22_RS12830	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G8J22_RS12835	COG0601	transmembrane transport
G8J22_RS12865	COG1940	carbohydrate kinase activity
G8J22_RS12885	COG0166	Belongs to the GPI family
G8J22_RS12895	COG1959	2 iron, 2 sulfur cluster binding
G8J22_RS12905	COG2814	Major facilitator Superfamily
G8J22_RS12910	COG1609	Transcriptional regulator
G8J22_RS12930	COG4475	Protein of unknown function (DUF436)
G8J22_RS12940	COG1619	proteins homologs of microcin C7 resistance protein MccF
G8J22_RS12955	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
G8J22_RS12975	COG2814	Major facilitator Superfamily
G8J22_RS13050	COG1127	ABC transporter
G8J22_RS13060	COG2226	methyltransferase
G8J22_RS13070	COG1064	alcohol dehydrogenase
G8J22_RS13105	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
G8J22_RS13110	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
G8J22_RS13120	COG2096	Adenosyltransferase
G8J22_RS13125	COG2186	Transcriptional regulator
G8J22_RS13130	COG2807	transmembrane transport
G8J22_RS13135	COG2814	Major facilitator Superfamily
G8J22_RS13140	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
G8J22_RS13160	COG0446	pyridine nucleotide-disulphide oxidoreductase
G8J22_RS13175	COG1053	succinate dehydrogenase
G8J22_RS13180	COG0114	fumarate hydratase activity
G8J22_RS13185	COG0028	Belongs to the TPP enzyme family
G8J22_RS13190	COG0196	riboflavin kinase activity
G8J22_RS13205	COG1131	(ABC) transporter
G8J22_RS13215	COG1396	sequence-specific DNA binding
G8J22_RS13225	COG0583	DNA-binding transcription factor activity
G8J22_RS13300	COG1131	(ABC) transporter
G8J22_RS13335	COG1937	Protein conserved in bacteria
G8J22_RS13345	COG1054	Belongs to the UPF0176 family
G8J22_RS13360	COG0267	Belongs to the bacterial ribosomal protein bL33 family
G8J22_RS13380	COG1131	(ABC) transporter
G8J22_RS13385	COG1725	Transcriptional regulator
G8J22_RS13390	COG1250	3-hydroxyacyl-CoA dehydrogenase
G8J22_RS13395	COG2814	Major facilitator Superfamily
G8J22_RS13405	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
G8J22_RS13410	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
G8J22_RS13440	COG2040	homocysteine
G8J22_RS13445	COG0833	amino acid
G8J22_RS13455	COG0583	DNA-binding transcription factor activity
G8J22_RS13460	COG0527	aspartate kinase activity
G8J22_RS13465	COG0460	homoserine dehydrogenase
G8J22_RS13500	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
G8J22_RS13520	COG0531	amino acid
G8J22_RS13530	COG2814	Major facilitator Superfamily
G8J22_RS13545	COG1114	Component of the transport system for branched-chain amino acids
G8J22_RS13560	COG0704	Plays a role in the regulation of phosphate uptake
G8J22_RS13565	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
G8J22_RS13575	COG0581	inorganic phosphate transmembrane transporter activity
G8J22_RS13580	COG0573	inorganic phosphate transmembrane transporter activity
G8J22_RS13590	COG0745	RESPONSE REGULATOR receiver
G8J22_RS13605	COG1012	belongs to the aldehyde dehydrogenase family
G8J22_RS13615	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
G8J22_RS13620	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
G8J22_RS13630	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
G8J22_RS13630	COG0512	Glutamine amidotransferase of anthranilate synthase
G8J22_RS13645	COG0406	alpha-ribazole phosphatase activity
G8J22_RS13655	COG2814	Major facilitator Superfamily
G8J22_RS13660	COG0445	tRNA wobble uridine modification
G8J22_RS13665	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
G8J22_RS13670	COG1847	R3H domain protein
G8J22_RS13685	COG0706	membrane insertase activity
G8J22_RS13690	COG0594	ribonuclease P activity
G8J22_RS13695	COG0230	Belongs to the bacterial ribosomal protein bL34 family