locus-tag	class	description
DNL43_RS00215	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
DNL43_RS00220	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DNL43_RS00225	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
DNL43_RS00240	COG0037	tRNA processing
DNL43_RS00245	COG1098	S1 RNA binding domain
DNL43_RS00255	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
DNL43_RS00260	COG2244	polysaccharide biosynthetic process
DNL43_RS00265	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
DNL43_RS00270	COG0193	aminoacyl-tRNA hydrolase activity
DNL43_RS00275	COG0039	L-malate dehydrogenase activity
DNL43_RS00285	COG2337	Toxic component of a toxin-antitoxin (TA) module
DNL43_RS00295	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DNL43_RS00310	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DNL43_RS00320	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DNL43_RS00325	COG3764	Sortase (surface protein transpeptidase)
DNL43_RS00335	COG0254	rRNA binding
DNL43_RS00340	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DNL43_RS00345	COG0504	CTP synthase activity
DNL43_RS00350	COG3343	RNA polymerase activity
DNL43_RS00360	COG0095	Lipoate-protein ligase
DNL43_RS00365	COG1078	dGTPase activity
DNL43_RS00370	COG0561	phosphatase activity
DNL43_RS00380	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DNL43_RS00385	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DNL43_RS00390	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DNL43_RS00395	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DNL43_RS00400	COG1121	(ABC) transporter
DNL43_RS00405	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
DNL43_RS00410	COG4466	Protein conserved in bacteria
DNL43_RS00415	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DNL43_RS00420	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
DNL43_RS00425	COG0084	hydrolase, TatD family'
DNL43_RS00430	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DNL43_RS00430	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DNL43_RS00435	COG1801	Protein of unknown function DUF72
DNL43_RS00440	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
DNL43_RS00455	COG0248	Ppx GppA phosphatase
DNL43_RS00465	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DNL43_RS00470	COG3973	AAA domain
DNL43_RS00480	COG0142	geranyltranstransferase activity
DNL43_RS00485	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
DNL43_RS00490	COG4988	ABC transporter
DNL43_RS00495	COG1294	oxidase, subunit
DNL43_RS00500	COG1271	oxidase subunit
DNL43_RS00510	COG2826	transposase and inactivated derivatives, IS30 family
DNL43_RS00515	COG1120	ATPase activity
DNL43_RS00560	COG1368	sulfuric ester hydrolase activity
DNL43_RS00570	COG0438	transferase activity, transferring glycosyl groups
DNL43_RS00575	COG0438	transferase activity, transferring glycosyl groups
DNL43_RS00580	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DNL43_RS00585	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DNL43_RS00595	COG0542	response to heat
DNL43_RS00615	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
DNL43_RS00625	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
DNL43_RS00630	COG0628	permease
DNL43_RS00635	COG3557	Belongs to the UPF0374 family
DNL43_RS00640	COG2137	regulation of response to DNA damage stimulus
DNL43_RS00645	COG0716	FMN binding
DNL43_RS00655	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
DNL43_RS00660	COG0463	Glycosyl transferase, family 2
DNL43_RS00665	COG2246	polysaccharide biosynthetic process
DNL43_RS00670	COG0765	amino acid transport
DNL43_RS00675	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DNL43_RS00690	COG0513	Belongs to the DEAD box helicase family
DNL43_RS00695	COG0673	inositol 2-dehydrogenase activity
DNL43_RS00710	COG1737	Transcriptional regulator
DNL43_RS00715	COG1070	Carbohydrate kinase
DNL43_RS00725	COG1268	BioY protein
DNL43_RS00735	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
DNL43_RS00740	COG0825	malonyl-CoA metabolic process
DNL43_RS00745	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
DNL43_RS00750	COG0439	Biotin carboxylase
DNL43_RS00760	COG0511	ligase activity, forming carbon-carbon bonds
DNL43_RS00765	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DNL43_RS00770	COG1028	Short-chain dehydrogenase reductase Sdr
DNL43_RS00775	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
DNL43_RS00780	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DNL43_RS00785	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DNL43_RS00795	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DNL43_RS00800	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
DNL43_RS00805	COG2390	Transcriptional regulator
DNL43_RS00810	COG0813	purine-nucleoside phosphorylase activity
DNL43_RS00815	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
DNL43_RS00820	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
DNL43_RS00840	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DNL43_RS00845	COG1597	lipid kinase activity
DNL43_RS00850	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DNL43_RS00855	COG0154	amidase activity
DNL43_RS00860	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DNL43_RS00865	COG4851	CamS sex pheromone cAM373 precursor
DNL43_RS00870	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DNL43_RS00880	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
DNL43_RS00885	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DNL43_RS00890	COG1705	Flagellar rod assembly protein muramidase FlgJ
DNL43_RS00905	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
DNL43_RS00910	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
DNL43_RS00915	COG0101	tRNA pseudouridine synthase activity
DNL43_RS00920	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
DNL43_RS00925	COG1122	ATPase activity
DNL43_RS00935	COG0203	ribosomal protein L17
DNL43_RS00940	COG0202	RNA polymerase activity
DNL43_RS00950	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
DNL43_RS00955	COG0257	Belongs to the bacterial ribosomal protein bL36 family
DNL43_RS00960	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
DNL43_RS00965	COG0563	adenylate kinase activity
DNL43_RS00975	COG0200	Binds to the 23S rRNA
DNL43_RS00985	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
DNL43_RS00990	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
DNL43_RS00995	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
DNL43_RS01000	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
DNL43_RS01005	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DNL43_RS01010	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
DNL43_RS01015	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
DNL43_RS01020	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
DNL43_RS01030	COG0255	Belongs to the universal ribosomal protein uL29 family
DNL43_RS01035	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
DNL43_RS01040	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
DNL43_RS01045	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
DNL43_RS01050	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
DNL43_RS01055	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
DNL43_RS01060	COG0089	rRNA binding
DNL43_RS01065	COG0088	Forms part of the polypeptide exit tunnel
DNL43_RS01070	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DNL43_RS01075	COG0051	transcription antitermination factor activity, RNA binding
DNL43_RS01080	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DNL43_RS01085	COG0049	tRNA binding
DNL43_RS01090	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
DNL43_RS01095	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
DNL43_RS01100	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DNL43_RS01105	COG0085	RNA polymerase activity
DNL43_RS01110	COG0542	response to heat
DNL43_RS01115	COG4463	regulation of RNA biosynthetic process
DNL43_RS01160	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
DNL43_RS01165	COG1428	Deoxynucleoside kinase
DNL43_RS01170	COG3684	Belongs to the aldolase LacD family
DNL43_RS01175	COG0833	amino acid
DNL43_RS01215	COG0436	Aminotransferase
DNL43_RS01220	COG0765	amino acid transport
DNL43_RS01225	COG1126	abc transporter atp-binding protein
DNL43_RS01320	COG2183	response to ionizing radiation
DNL43_RS01325	COG0586	Pfam SNARE associated Golgi protein
DNL43_RS01335	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DNL43_RS01340	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
DNL43_RS01340	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
DNL43_RS01345	COG5416	Lipopolysaccharide assembly protein A domain
DNL43_RS01350	COG1234	tRNA 3'-trailer cleavage
DNL43_RS01370	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
DNL43_RS01370	COG2755	lipolytic protein G-D-S-L family
DNL43_RS01375	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
DNL43_RS01380	COG0322	excinuclease ABC activity
DNL43_RS01385	COG1126	abc transporter atp-binding protein
DNL43_RS01390	COG0765	amino acid transport
DNL43_RS01400	COG0137	argininosuccinate synthase activity
DNL43_RS01410	COG0218	Necessary for normal cell division and for the maintenance of normal septation
DNL43_RS01415	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
DNL43_RS01420	COG0544	peptidyl-prolyl cis-trans isomerase activity
DNL43_RS01425	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DNL43_RS01440	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
DNL43_RS01445	COG0268	Binds directly to 16S ribosomal RNA
DNL43_RS01450	COG1466	dna polymerase III delta subunit
DNL43_RS01455	COG0658	competence protein
DNL43_RS01455	COG2333	competence protein COMEC
DNL43_RS01460	COG2131	deaminase
DNL43_RS01465	COG1555	photosystem II stabilization
DNL43_RS01475	COG3480	Lon protease (S16) C-terminal proteolytic domain
DNL43_RS01480	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
DNL43_RS01485	COG0742	ribosomal rna small subunit methyltransferase
DNL43_RS01495	COG0772	Belongs to the SEDS family
DNL43_RS01500	COG1217	gtp-binding protein TYPA
DNL43_RS01505	COG0483	inositol monophosphate 1-phosphatase activity
DNL43_RS01510	COG4476	Belongs to the UPF0223 family
DNL43_RS01535	COG0242	peptide deformylase activity
DNL43_RS01555	COG5503	Protein of unknown function (DUF1447)
DNL43_RS01585	COG1609	Transcriptional regulator
DNL43_RS01590	COG0667	Aldo Keto reductase
DNL43_RS01595	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DNL43_RS01600	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DNL43_RS01620	COG0482	sulfurtransferase activity
DNL43_RS01625	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DNL43_RS01630	COG0140	phosphoribosyl-ATP diphosphatase activity
DNL43_RS01630	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
DNL43_RS01635	COG0107	imidazoleglycerol-phosphate synthase activity
DNL43_RS01640	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
DNL43_RS01665	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
DNL43_RS01675	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DNL43_RS01685	COG1104	cysteine desulfurase activity
DNL43_RS01700	COG0494	nUDIX hydrolase
DNL43_RS01705	COG1278	Cold shock
DNL43_RS01710	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DNL43_RS01715	COG3599	regulation of cell shape
DNL43_RS01730	COG1799	cell septum assembly
DNL43_RS01745	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
DNL43_RS01750	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DNL43_RS01755	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DNL43_RS01760	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DNL43_RS01765	COG0768	penicillin binding
DNL43_RS01775	COG0275	rRNA processing
DNL43_RS01780	COG2001	Belongs to the MraZ family
DNL43_RS01795	COG1674	ftsk spoiiie
DNL43_RS01805	COG0500	methyltransferase
DNL43_RS01810	COG0564	pseudouridine synthase activity
DNL43_RS01815	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DNL43_RS01820	COG2357	RelA SpoT domain protein
DNL43_RS01845	COG5002	protein histidine kinase activity
DNL43_RS01850	COG0745	RESPONSE REGULATOR receiver
DNL43_RS01860	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
DNL43_RS01865	COG0463	Glycosyl transferase, family 2
DNL43_RS01870	COG4862	establishment of competence for transformation
DNL43_RS01875	COG1393	Belongs to the ArsC family
DNL43_RS01880	COG1234	tRNA 3'-trailer cleavage
DNL43_RS01890	COG2826	transposase and inactivated derivatives, IS30 family
DNL43_RS02015	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DNL43_RS02030	COG0789	Transcriptional regulator
DNL43_RS02040	COG2084	Dehydrogenase
DNL43_RS02055	COG2826	transposase and inactivated derivatives, IS30 family
DNL43_RS02065	COG0626	cystathionine gamma-synthase activity
DNL43_RS02075	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DNL43_RS02095	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DNL43_RS02105	COG1272	protein, Hemolysin III
DNL43_RS02125	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DNL43_RS02130	COG1802	Transcriptional regulator
DNL43_RS02135	COG1686	Belongs to the peptidase S11 family
DNL43_RS02150	COG0604	alcohol dehydrogenase
DNL43_RS02165	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
DNL43_RS02185	COG2826	transposase and inactivated derivatives, IS30 family
DNL43_RS02190	COG0477	Major facilitator Superfamily
DNL43_RS02220	COG1312	Catalyzes the dehydration of D-mannonate
DNL43_RS02240	COG3250	beta-galactosidase activity
DNL43_RS02255	COG2233	PERMEase
DNL43_RS02270	COG1278	Cold shock
DNL43_RS02275	COG4221	oxidoreductase activity
DNL43_RS02285	COG0110	maltose O-acetyltransferase activity
DNL43_RS02290	COG0531	amino acid
DNL43_RS02295	COG0588	phosphoglycerate mutase activity
DNL43_RS02300	COG0628	permease
DNL43_RS02330	COG1686	Belongs to the peptidase S11 family
DNL43_RS02340	COG0745	RESPONSE REGULATOR receiver
DNL43_RS02345	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
DNL43_RS02360	COG0517	IMP dehydrogenase activity
DNL43_RS02360	COG0516	GMP reductase activity
DNL43_RS02370	COG0012	GTP binding
DNL43_RS02375	COG4481	Protein conserved in bacteria
DNL43_RS02380	COG1475	DNA binding
DNL43_RS02385	COG1192	Involved in chromosome partitioning
DNL43_RS02390	COG0357	Ribosomal RNA small subunit methyltransferase G
DNL43_RS02405	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DNL43_RS02410	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
DNL43_RS02465	COG3760	aminoacyl-tRNA metabolism involved in translational fidelity
DNL43_RS02500	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DNL43_RS02530	COG2826	transposase and inactivated derivatives, IS30 family
DNL43_RS02545	COG1307	EDD domain protein, DegV family
DNL43_RS02560	COG1136	(ABC) transporter
DNL43_RS02560	COG0577	efflux transmembrane transporter activity
DNL43_RS02610	COG0352	thiamine-phosphate diphosphorylase activity
DNL43_RS02615	COG0351	phosphomethylpyrimidine kinase
DNL43_RS02620	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
DNL43_RS02625	COG0300	oxidoreductase activity
DNL43_RS02635	COG0656	L-ascorbic acid biosynthetic process
DNL43_RS02640	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DNL43_RS02655	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DNL43_RS02695	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DNL43_RS02750	COG1285	pathogenesis
DNL43_RS02755	COG1705	Flagellar rod assembly protein muramidase FlgJ
DNL43_RS02755	COG1388	LysM domain
DNL43_RS02760	COG1757	Na H antiporter
DNL43_RS02775	COG3118	belongs to the thioredoxin family
DNL43_RS02780	COG0861	Integral membrane protein TerC family
DNL43_RS02785	COG1705	Flagellar rod assembly protein muramidase FlgJ
DNL43_RS02815	COG0588	phosphoglycerate mutase activity
DNL43_RS02820	COG1368	sulfuric ester hydrolase activity
DNL43_RS02825	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DNL43_RS02840	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DNL43_RS02845	COG0492	ferredoxin-NADP+ reductase activity
DNL43_RS02870	COG0561	phosphatase activity
DNL43_RS02875	COG1393	Belongs to the ArsC family
DNL43_RS02880	COG0025	NhaP-type Na H and K H
DNL43_RS02885	COG0737	Belongs to the 5'-nucleotidase family
DNL43_RS02890	COG1418	mRNA catabolic process
DNL43_RS02900	COG1396	sequence-specific DNA binding
DNL43_RS02910	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DNL43_RS02925	COG0546	phosphoglycolate phosphatase activity
DNL43_RS02950	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DNL43_RS02965	COG4485	Bacterial membrane protein, YfhO
DNL43_RS02970	COG1438	arginine binding
DNL43_RS02980	COG0583	DNA-binding transcription factor activity
DNL43_RS02985	COG2233	PERMEase
DNL43_RS03005	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DNL43_RS03010	COG0586	Pfam SNARE associated Golgi protein
DNL43_RS03015	COG4989	oxidoreductase activity
DNL43_RS03025	COG1028	Short-chain dehydrogenase reductase Sdr
DNL43_RS03030	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
DNL43_RS03045	COG2755	lipolytic protein G-D-S-L family
DNL43_RS03045	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
DNL43_RS03050	COG0488	(ABC) transporter
DNL43_RS03085	COG1215	transferase activity, transferring glycosyl groups
DNL43_RS03100	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DNL43_RS03125	COG1131	(ABC) transporter
DNL43_RS03130	COG0656	L-ascorbic acid biosynthetic process
DNL43_RS03145	COG2814	Major facilitator Superfamily
DNL43_RS03155	COG3428	Bacterial PH domain
DNL43_RS03160	COG0656	L-ascorbic acid biosynthetic process
DNL43_RS03165	COG0095	Lipoate-protein ligase
DNL43_RS03170	COG0509	glycine decarboxylation via glycine cleavage system
DNL43_RS03175	COG0519	Catalyzes the synthesis of GMP from XMP
DNL43_RS03190	COG1376	ErfK ybiS ycfS ynhG family protein
DNL43_RS03200	COG2936	dipeptidyl-peptidase activity
DNL43_RS03210	COG2801	Transposase and inactivated derivatives
DNL43_RS03245	COG0656	L-ascorbic acid biosynthetic process
DNL43_RS03270	COG1522	sequence-specific DNA binding
DNL43_RS03275	COG1113	amino acid transport
DNL43_RS03295	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DNL43_RS03305	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
DNL43_RS03310	COG0284	orotidine-5'-phosphate decarboxylase activity
DNL43_RS03315	COG2814	Major facilitator Superfamily
DNL43_RS03345	COG0151	Belongs to the GarS family
DNL43_RS03350	COG0138	bifunctional purine biosynthesis protein purh
DNL43_RS03355	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
DNL43_RS03370	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DNL43_RS03375	COG0047	phosphoribosylformylglycinamidine synthase activity
DNL43_RS03380	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DNL43_RS03385	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
DNL43_RS03390	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
DNL43_RS03395	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
DNL43_RS03400	COG0667	Aldo Keto reductase
DNL43_RS03430	COG0004	ammonium transporteR
DNL43_RS03445	COG1012	belongs to the aldehyde dehydrogenase family
DNL43_RS03450	COG2814	Major facilitator Superfamily
DNL43_RS03460	COG1914	H( )-stimulated, divalent metal cation uptake system
DNL43_RS03480	COG1960	acyl-CoA dehydrogenase activity
DNL43_RS03485	COG2086	electron transfer activity
DNL43_RS03490	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
DNL43_RS03525	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
DNL43_RS03530	COG1131	(ABC) transporter
DNL43_RS03540	COG1309	transcriptional regulator
DNL43_RS03555	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
DNL43_RS03560	COG1393	Belongs to the ArsC family
DNL43_RS03575	COG0248	Ppx GppA phosphatase
DNL43_RS03580	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
DNL43_RS03590	COG0667	Aldo Keto reductase
DNL43_RS03605	COG2217	Heavy metal translocating P-type atpase
DNL43_RS03610	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DNL43_RS03615	COG2957	Belongs to the agmatine deiminase family
DNL43_RS03625	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
DNL43_RS03640	COG1136	(ABC) transporter
DNL43_RS03670	COG0386	Belongs to the glutathione peroxidase family
DNL43_RS03675	COG1132	(ABC) transporter
DNL43_RS03695	COG0095	Lipoate-protein ligase
DNL43_RS03710	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DNL43_RS03720	COG2826	transposase and inactivated derivatives, IS30 family
DNL43_RS03735	COG0436	Aminotransferase
DNL43_RS03770	COG4166	transmembrane transport
DNL43_RS03780	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
DNL43_RS03785	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DNL43_RS03800	COG2076	Multidrug Resistance protein
DNL43_RS03805	COG0494	nUDIX hydrolase
DNL43_RS03815	COG0540	Belongs to the ATCase OTCase family
DNL43_RS03830	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DNL43_RS03865	COG1301	dicarboxylic acid transport
DNL43_RS03885	COG0183	Belongs to the thiolase family
DNL43_RS03910	COG0626	cystathionine gamma-synthase activity
DNL43_RS03915	COG1074	ATP-dependent DNA helicase activity
DNL43_RS03920	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
DNL43_RS03940	COG0667	Aldo Keto reductase
DNL43_RS03945	COG2252	PERMEase
DNL43_RS03950	COG4708	membrane
DNL43_RS03960	COG2357	RelA SpoT domain protein
DNL43_RS03965	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DNL43_RS03970	COG0477	Major facilitator Superfamily
DNL43_RS03975	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DNL43_RS04010	COG0159	tryptophan synthase activity
DNL43_RS04030	COG2244	polysaccharide biosynthetic process
DNL43_RS04080	COG0601	transmembrane transport
DNL43_RS04085	COG4608	Belongs to the ABC transporter superfamily
DNL43_RS04125	COG2826	transposase and inactivated derivatives, IS30 family
DNL43_RS04135	COG2910	NAD(P)H-binding
DNL43_RS04150	COG1940	carbohydrate kinase activity
DNL43_RS04155	COG1063	alcohol dehydrogenase
DNL43_RS04170	COG0166	Belongs to the GPI family
DNL43_RS04225	COG1132	(ABC) transporter
DNL43_RS04235	COG1132	(ABC) transporter
DNL43_RS04300	COG1609	Transcriptional regulator
DNL43_RS04320	COG4475	Protein of unknown function (DUF436)
DNL43_RS04335	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
DNL43_RS04345	COG2814	Major facilitator Superfamily
DNL43_RS04360	COG3048	D-serine ammonia-lyase activity
DNL43_RS04380	COG1668	transmembrane transport
DNL43_RS04385	COG4152	abc transporter atp-binding protein
DNL43_RS04390	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
DNL43_RS04405	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DNL43_RS04410	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DNL43_RS04415	COG2096	Adenosyltransferase
DNL43_RS04420	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DNL43_RS04430	COG0114	fumarate hydratase activity
DNL43_RS04470	COG1131	(ABC) transporter
DNL43_RS04475	COG1725	Transcriptional regulator
DNL43_RS04480	COG1131	(ABC) transporter
DNL43_RS04500	COG1250	3-hydroxyacyl-CoA dehydrogenase
DNL43_RS04505	COG0488	(ABC) transporter
DNL43_RS04510	COG2814	Major facilitator Superfamily
DNL43_RS04520	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DNL43_RS04525	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DNL43_RS04550	COG0583	DNA-binding transcription factor activity
DNL43_RS04560	COG0527	aspartate kinase activity
DNL43_RS04565	COG0460	homoserine dehydrogenase
DNL43_RS04590	COG0604	alcohol dehydrogenase
DNL43_RS04595	COG1968	undecaprenyl-diphosphatase activity
DNL43_RS04620	COG0531	amino acid
DNL43_RS04650	COG0406	alpha-ribazole phosphatase activity
DNL43_RS04655	COG2814	Major facilitator Superfamily
DNL43_RS04680	COG1114	Component of the transport system for branched-chain amino acids
DNL43_RS04750	COG2814	Major facilitator Superfamily
DNL43_RS04755	COG2130	NADP-dependent
DNL43_RS04815	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DNL43_RS04825	COG0581	inorganic phosphate transmembrane transporter activity
DNL43_RS04830	COG0573	inorganic phosphate transmembrane transporter activity
DNL43_RS04855	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DNL43_RS04860	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
DNL43_RS04870	COG0512	Glutamine amidotransferase of anthranilate synthase
DNL43_RS04870	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DNL43_RS04880	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DNL43_RS04895	COG0681	Belongs to the peptidase S26 family
DNL43_RS04900	COG2814	Major facilitator Superfamily
DNL43_RS04905	COG0445	tRNA wobble uridine modification
DNL43_RS04910	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
DNL43_RS04915	COG1847	R3H domain protein
DNL43_RS04920	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
DNL43_RS04930	COG0604	alcohol dehydrogenase
DNL43_RS04935	COG0640	Transcriptional regulator
DNL43_RS04945	COG1929	Belongs to the glycerate kinase type-1 family
DNL43_RS04950	COG0706	membrane insertase activity
DNL43_RS04955	COG0594	ribonuclease P activity
DNL43_RS04960	COG0230	Belongs to the bacterial ribosomal protein bL34 family
DNL43_RS04965	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
DNL43_RS04970	COG0592	DNA-directed DNA polymerase activity
DNL43_RS04975	COG2501	S4 domain
DNL43_RS04980	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DNL43_RS04985	COG0187	DNA topoisomerase II activity
DNL43_RS04995	COG1304	FMN binding
DNL43_RS05005	COG2826	transposase and inactivated derivatives, IS30 family
DNL43_RS05010	COG0360	Binds together with S18 to 16S ribosomal RNA
DNL43_RS05015	COG0629	single-stranded DNA binding
DNL43_RS05020	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
DNL43_RS05025	COG1757	Na H antiporter
DNL43_RS05030	COG1113	amino acid transport
DNL43_RS05040	COG0359	binds to the 23S rRNA
DNL43_RS05045	COG0305	Participates in initiation and elongation during chromosome replication
DNL43_RS05055	COG0745	RESPONSE REGULATOR receiver
DNL43_RS05060	COG5002	protein histidine kinase activity
DNL43_RS05085	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
DNL43_RS05090	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DNL43_RS05100	COG2826	transposase and inactivated derivatives, IS30 family
DNL43_RS05105	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
DNL43_RS05115	COG1028	Short-chain dehydrogenase reductase Sdr
DNL43_RS05120	COG4166	transmembrane transport
DNL43_RS05125	COG1363	Peptidase, m42
DNL43_RS05130	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
DNL43_RS05155	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DNL43_RS05175	COG1609	Transcriptional regulator
DNL43_RS05180	COG0667	Aldo Keto reductase
DNL43_RS05200	COG1250	3-hydroxyacyl-CoA dehydrogenase
DNL43_RS05205	COG3527	Alpha-acetolactate decarboxylase
DNL43_RS05210	COG0028	Belongs to the TPP enzyme family
DNL43_RS05270	COG1902	pentaerythritol trinitrate reductase activity
DNL43_RS05295	COG2826	transposase and inactivated derivatives, IS30 family
DNL43_RS05320	COG2211	Major facilitator Superfamily
DNL43_RS05330	COG1904	glucuronate isomerase
DNL43_RS05335	COG1609	Transcriptional regulator
DNL43_RS05370	COG0420	3'-5' exonuclease activity
DNL43_RS05440	COG1397	ADP-ribosylglycohydrolase
DNL43_RS05470	COG0737	Belongs to the 5'-nucleotidase family
DNL43_RS05475	COG0406	alpha-ribazole phosphatase activity
DNL43_RS05535	COG0702	epimerase
DNL43_RS05540	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DNL43_RS05545	COG1288	antiporter activity
DNL43_RS05570	COG1573	uracil-dna glycosylase
DNL43_RS05575	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DNL43_RS05580	COG1113	amino acid transport
DNL43_RS05590	COG0157	Belongs to the NadC ModD family
DNL43_RS05595	COG0477	Major facilitator Superfamily
DNL43_RS05625	COG1175	transmembrane transport
DNL43_RS05630	COG0395	ABC-type sugar transport system, permease component
DNL43_RS05640	COG0584	glycerophosphoryl diester phosphodiesterase
DNL43_RS05645	COG4166	transmembrane transport
DNL43_RS05665	COG1914	H( )-stimulated, divalent metal cation uptake system
DNL43_RS05680	COG2135	peptidase activity
DNL43_RS05690	COG0789	Transcriptional regulator
DNL43_RS05690	COG4978	Transcriptional regulator
DNL43_RS05695	COG0667	Aldo Keto reductase
DNL43_RS05705	COG1472	Belongs to the glycosyl hydrolase 3 family
DNL43_RS05710	COG0493	'glutamate synthase
DNL43_RS05715	COG0069	glutamate synthase activity
DNL43_RS05715	COG0067	glutamate synthase
DNL43_RS05715	COG0070	glutamate synthase
DNL43_RS05725	COG0719	Fe-S assembly protein
DNL43_RS05730	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DNL43_RS05740	COG0719	Fe-S assembly protein
DNL43_RS05745	COG2151	metal-sulfur cluster biosynthetic enzyme
DNL43_RS05770	COG1595	DNA-templated transcription, initiation
DNL43_RS05775	COG3001	Fructosamine kinase
DNL43_RS05780	COG0446	pyridine nucleotide-disulphide oxidoreductase
DNL43_RS05780	COG1902	pentaerythritol trinitrate reductase activity
DNL43_RS05790	COG0667	Aldo Keto reductase
DNL43_RS05795	COG0783	Belongs to the Dps family
DNL43_RS05800	COG0477	Major facilitator Superfamily
DNL43_RS05805	COG1011	Hydrolase
DNL43_RS05810	COG3527	Alpha-acetolactate decarboxylase
DNL43_RS05835	COG2323	membrane
DNL43_RS05860	COG0477	Major facilitator Superfamily
DNL43_RS05865	COG4716	Myosin-crossreactive antigen
DNL43_RS05880	COG2207	Transcriptional regulator
DNL43_RS05895	COG2207	Transcriptional regulator
DNL43_RS05915	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DNL43_RS05920	COG1704	LemA family
DNL43_RS05925	COG0501	Belongs to the peptidase M48B family
DNL43_RS05930	COG0174	glutamine synthetase
DNL43_RS05935	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DNL43_RS05960	COG1028	Short-chain dehydrogenase reductase Sdr
DNL43_RS05965	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DNL43_RS05970	COG1114	Component of the transport system for branched-chain amino acids
DNL43_RS05975	COG1335	isochorismatase
DNL43_RS06000	COG1609	Transcriptional regulator
DNL43_RS06015	COG2807	transmembrane transport
DNL43_RS06020	COG0697	spore germination
DNL43_RS06025	COG2918	glutathione biosynthetic process
DNL43_RS06025	COG1181	Belongs to the D-alanine--D-alanine ligase family
DNL43_RS06035	COG0656	L-ascorbic acid biosynthetic process
DNL43_RS06040	COG0789	Transcriptional regulator
DNL43_RS06045	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
DNL43_RS06055	COG1132	(ABC) transporter
DNL43_RS06060	COG1132	(ABC) transporter
DNL43_RS06090	COG0778	Nitroreductase
DNL43_RS06095	COG0765	amino acid transport
DNL43_RS06100	COG0765	amino acid transport
DNL43_RS06105	COG1126	abc transporter atp-binding protein
DNL43_RS06115	COG0738	Major facilitator superfamily
DNL43_RS06120	COG0710	3-dehydroquinate dehydratase activity
DNL43_RS06125	COG0726	polysaccharide deacetylase
DNL43_RS06140	COG0287	Prephenate dehydrogenase
DNL43_RS06140	COG1605	Chorismate mutase
DNL43_RS06145	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
DNL43_RS06150	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
DNL43_RS06155	COG0287	Prephenate dehydrogenase
DNL43_RS06160	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
DNL43_RS06165	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DNL43_RS06175	COG1609	Transcriptional regulator
DNL43_RS06180	COG2190	(PTS) system
DNL43_RS06180	COG2211	Major facilitator Superfamily
DNL43_RS06190	COG0477	Major facilitator Superfamily
DNL43_RS06200	COG1307	EDD domain protein, DegV family
DNL43_RS06255	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
DNL43_RS06280	COG1301	dicarboxylic acid transport
DNL43_RS06285	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DNL43_RS06290	COG2022	thiamine diphosphate biosynthetic process
DNL43_RS06295	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DNL43_RS06305	COG0352	thiamine-phosphate diphosphorylase activity
DNL43_RS06315	COG3620	sequence-specific DNA binding
DNL43_RS06320	COG1131	(ABC) transporter
DNL43_RS06330	COG1476	TRANSCRIPTIONal
DNL43_RS06340	COG1131	(ABC) transporter
DNL43_RS06345	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
DNL43_RS06355	COG2826	transposase and inactivated derivatives, IS30 family
DNL43_RS06420	COG0745	RESPONSE REGULATOR receiver
DNL43_RS06425	COG2205	protein histidine kinase activity
DNL43_RS06435	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
DNL43_RS06450	COG0110	maltose O-acetyltransferase activity
DNL43_RS06455	COG2814	Major facilitator Superfamily
DNL43_RS06470	COG1253	flavin adenine dinucleotide binding
DNL43_RS06485	COG0656	L-ascorbic acid biosynthetic process
DNL43_RS06490	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DNL43_RS06500	COG1012	belongs to the aldehyde dehydrogenase family
DNL43_RS06500	COG1454	alcohol dehydrogenase
DNL43_RS06505	COG2207	Transcriptional regulator
DNL43_RS06505	COG1917	Cupin 2, conserved barrel domain protein
DNL43_RS06510	COG2814	Major facilitator Superfamily
DNL43_RS06530	COG1418	mRNA catabolic process
DNL43_RS06540	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
DNL43_RS06545	COG2188	Transcriptional regulator
DNL43_RS06565	COG0564	pseudouridine synthase activity
DNL43_RS06575	COG0095	Lipoate-protein ligase
DNL43_RS06590	COG0604	alcohol dehydrogenase
DNL43_RS06610	COG0531	amino acid
DNL43_RS06615	COG2814	Major facilitator Superfamily
DNL43_RS06630	COG0791	NLP P60 protein
DNL43_RS06630	COG1388	LysM domain
DNL43_RS06630	COG3103	Sh3 type 3 domain protein
DNL43_RS06645	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
DNL43_RS06655	COG1131	(ABC) transporter
DNL43_RS06675	COG2211	Major facilitator Superfamily
DNL43_RS06700	COG2814	Major facilitator Superfamily
DNL43_RS06715	COG0246	Mannitol dehydrogenase
DNL43_RS06720	COG1904	glucuronate isomerase
DNL43_RS06730	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DNL43_RS06735	COG1070	Carbohydrate kinase
DNL43_RS06740	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
DNL43_RS06745	COG2017	converts alpha-aldose to the beta-anomer
DNL43_RS06750	COG1609	Transcriptional regulator
DNL43_RS06760	COG2160	L-arabinose isomerase activity
DNL43_RS06765	COG0110	maltose O-acetyltransferase activity
DNL43_RS06770	COG0656	L-ascorbic acid biosynthetic process
DNL43_RS06780	COG0488	(ABC) transporter
DNL43_RS06805	COG1307	EDD domain protein, DegV family
DNL43_RS06810	COG0708	Exodeoxyribonuclease III
DNL43_RS06830	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DNL43_RS06835	COG1609	Transcriptional regulator
DNL43_RS06840	COG1307	EDD domain protein, DegV family
DNL43_RS06865	COG0095	Lipoate-protein ligase
DNL43_RS06875	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DNL43_RS06885	COG1132	(ABC) transporter
DNL43_RS06900	COG2207	Transcriptional regulator
DNL43_RS06920	COG1278	Cold shock
DNL43_RS06925	COG0542	response to heat
DNL43_RS06935	COG2249	NAD(P)H dehydrogenase (quinone) activity
DNL43_RS06950	COG0667	Aldo Keto reductase
DNL43_RS06955	COG0351	phosphomethylpyrimidine kinase
DNL43_RS06960	COG0569	domain protein
DNL43_RS06965	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DNL43_RS06970	COG0402	S-adenosylhomocysteine deaminase activity
DNL43_RS06980	COG0328	RNA-DNA hybrid ribonuclease activity
DNL43_RS06985	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
DNL43_RS06995	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DNL43_RS07000	COG3189	MarR family transcriptional regulator
DNL43_RS07005	COG2094	Belongs to the DNA glycosylase MPG family
DNL43_RS07010	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
DNL43_RS07015	COG0024	Methionine aminopeptidase
DNL43_RS07020	COG3590	peptidase
DNL43_RS07025	COG2326	polyphosphate kinase activity
DNL43_RS07060	COG1131	(ABC) transporter
DNL43_RS07065	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DNL43_RS07070	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
DNL43_RS07075	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
DNL43_RS07095	COG1063	alcohol dehydrogenase
DNL43_RS07105	COG0589	response to stress
DNL43_RS07125	COG1732	Glycine betaine
DNL43_RS07130	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
DNL43_RS07140	COG3266	domain, Protein
DNL43_RS07140	COG4193	domain, Protein
DNL43_RS07140	COG5632	N-Acetylmuramoyl-L-alanine amidase
DNL43_RS07145	COG0735	belongs to the Fur family
DNL43_RS07155	COG2706	6-phosphogluconolactonase activity
DNL43_RS07160	COG0179	Fumarylacetoacetate (FAA) hydrolase
DNL43_RS07165	COG1199	ATP-dependent helicase activity
DNL43_RS07180	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
DNL43_RS07185	COG0527	aspartate kinase activity
DNL43_RS07195	COG2171	N-acyltransferase activity
DNL43_RS07200	COG1473	amidohydrolase
DNL43_RS07205	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DNL43_RS07210	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
DNL43_RS07215	COG0436	Aminotransferase
DNL43_RS07220	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
DNL43_RS07230	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
DNL43_RS07245	COG2814	Major facilitator Superfamily
DNL43_RS07255	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
DNL43_RS07260	COG1177	transmembrane transport
DNL43_RS07265	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
DNL43_RS07320	COG4172	Belongs to the ABC transporter superfamily
DNL43_RS07335	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
DNL43_RS07360	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
DNL43_RS07385	COG0656	L-ascorbic acid biosynthetic process
DNL43_RS07415	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
DNL43_RS07420	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DNL43_RS07435	COG0402	S-adenosylhomocysteine deaminase activity
DNL43_RS07440	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
DNL43_RS07445	COG0196	riboflavin kinase activity
DNL43_RS07450	COG0028	Belongs to the TPP enzyme family
DNL43_RS07455	COG2826	transposase and inactivated derivatives, IS30 family
DNL43_RS07485	COG0514	ATP-dependent DNA helicase (RecQ)
DNL43_RS07490	COG2814	Major facilitator Superfamily
DNL43_RS07495	COG0791	NLP P60 protein
DNL43_RS07505	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
DNL43_RS07510	COG1122	ATPase activity
DNL43_RS07520	COG0730	response to heat
DNL43_RS07530	COG0531	amino acid
DNL43_RS07555	COG1881	PFAM PEBP family protein
DNL43_RS07565	COG2153	protein acetylation
DNL43_RS07575	COG0456	acetyltransferase
DNL43_RS07580	COG2801	Transposase and inactivated derivatives
DNL43_RS07595	COG1846	Transcriptional regulator
DNL43_RS07610	COG3655	Transcriptional regulator
DNL43_RS07615	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DNL43_RS07620	COG1288	antiporter activity
DNL43_RS07630	COG4120	Belongs to the binding-protein-dependent transport system permease family
DNL43_RS07650	COG1518	maintenance of DNA repeat elements
DNL43_RS07705	COG3940	Belongs to the glycosyl hydrolase 43 family
DNL43_RS07710	COG2211	Major facilitator Superfamily
DNL43_RS07745	COG0488	(ABC) transporter
DNL43_RS07770	COG2267	carboxylic ester hydrolase activity
DNL43_RS07775	COG2936	dipeptidyl-peptidase activity
DNL43_RS07780	COG2207	Transcriptional regulator
DNL43_RS07785	COG3250	beta-galactosidase activity
DNL43_RS07790	COG2211	Major facilitator Superfamily
DNL43_RS07805	COG0194	GDP metabolic process
DNL43_RS07810	COG0735	belongs to the Fur family
DNL43_RS07835	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DNL43_RS07840	COG0765	amino acid transport
DNL43_RS07845	COG0765	amino acid transport
DNL43_RS07850	COG1285	pathogenesis
DNL43_RS07870	COG0366	Alpha amylase catalytic
DNL43_RS07885	COG0531	amino acid
DNL43_RS07890	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DNL43_RS07900	COG4166	transmembrane transport
DNL43_RS07905	COG0601	transmembrane transport
DNL43_RS07910	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DNL43_RS07915	COG0444	Belongs to the ABC transporter superfamily
DNL43_RS07920	COG4608	Belongs to the ABC transporter superfamily
DNL43_RS07945	COG1694	Mazg nucleotide pyrophosphohydrolase
DNL43_RS07950	COG0588	phosphoglycerate mutase activity
DNL43_RS07955	COG3973	AAA domain
DNL43_RS07960	COG1072	(Pantothenic acid kinase))
DNL43_RS07965	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DNL43_RS07965	COG0519	Catalyzes the synthesis of GMP from XMP
DNL43_RS07970	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
DNL43_RS07980	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DNL43_RS08000	COG0308	aminopeptidase N
DNL43_RS08020	COG1247	-acetyltransferase
DNL43_RS08060	COG2826	transposase and inactivated derivatives, IS30 family
DNL43_RS08070	COG2814	Major facilitator Superfamily
DNL43_RS08085	COG0789	Transcriptional regulator
DNL43_RS08095	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DNL43_RS08100	COG0450	alkyl hydroperoxide reductase
DNL43_RS08110	COG0477	Major facilitator Superfamily
DNL43_RS08120	COG0446	pyridine nucleotide-disulphide oxidoreductase
DNL43_RS08125	COG1473	amidohydrolase
DNL43_RS08140	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
DNL43_RS08150	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
DNL43_RS08155	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
DNL43_RS08160	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DNL43_RS08165	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DNL43_RS08185	COG0393	Putative heavy-metal-binding
DNL43_RS08190	COG0446	pyridine nucleotide-disulphide oxidoreductase
DNL43_RS08195	COG0564	pseudouridine synthase activity
DNL43_RS08210	COG1396	sequence-specific DNA binding
DNL43_RS08210	COG3800	Transcriptional regulator
DNL43_RS08245	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DNL43_RS08245	COG1321	iron dependent repressor
DNL43_RS08280	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DNL43_RS08290	COG0110	maltose O-acetyltransferase activity
DNL43_RS08295	COG3830	Belongs to the UPF0237 family
DNL43_RS08300	COG2848	UPF0210 protein
DNL43_RS08305	COG2153	protein acetylation
DNL43_RS08330	COG2409	Drug exporters of the RND superfamily
DNL43_RS08330	COG1033	growth of symbiont in host cell
DNL43_RS08350	COG1027	Aspartate ammonia-lyase
DNL43_RS08355	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DNL43_RS08360	COG1846	Transcriptional regulator
DNL43_RS08385	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DNL43_RS08395	COG1012	belongs to the aldehyde dehydrogenase family
DNL43_RS08405	COG2814	Major facilitator Superfamily
DNL43_RS08425	COG1902	pentaerythritol trinitrate reductase activity
DNL43_RS08455	COG1892	Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four- carbon dicarboxylic acid source for the tricarboxylic acid cycle
DNL43_RS08540	COG0561	phosphatase activity
DNL43_RS08550	COG0745	RESPONSE REGULATOR receiver
DNL43_RS08555	COG5002	protein histidine kinase activity
DNL43_RS08555	COG3850	Histidine kinase
DNL43_RS08580	COG2826	transposase and inactivated derivatives, IS30 family
DNL43_RS08605	COG2315	Protein conserved in bacteria
DNL43_RS08620	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DNL43_RS08625	COG3442	glutamine amidotransferase
DNL43_RS08630	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DNL43_RS08635	COG1435	thymidine kinase activity
DNL43_RS08640	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
DNL43_RS08645	COG2890	protein-(glutamine-N5) methyltransferase activity
DNL43_RS08650	COG0009	L-threonylcarbamoyladenylate synthase
DNL43_RS08655	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DNL43_RS08660	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
DNL43_RS08665	COG0356	it plays a direct role in the translocation of protons across the membrane
DNL43_RS08670	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DNL43_RS08675	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
DNL43_RS08680	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DNL43_RS08690	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
DNL43_RS08695	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
DNL43_RS08700	COG0355	proton-transporting ATP synthase activity, rotational mechanism
DNL43_RS08705	COG4836	Membrane
DNL43_RS08710	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DNL43_RS08715	COG1077	Cell shape determining protein MreB Mrl
DNL43_RS08720	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
DNL43_RS08730	COG0772	Belongs to the SEDS family
DNL43_RS08735	COG0509	glycine decarboxylation via glycine cleavage system
DNL43_RS08740	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DNL43_RS08745	COG2011	ABC-type metal ion transport system permease component
DNL43_RS08750	COG1464	Belongs to the NlpA lipoprotein family
DNL43_RS08760	COG1136	(ABC) transporter
DNL43_RS08770	COG1725	Transcriptional regulator
DNL43_RS08775	COG1131	(ABC) transporter
DNL43_RS08785	COG1181	Belongs to the D-alanine--D-alanine ligase family
DNL43_RS08795	COG2818	Glycosylase
DNL43_RS08820	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DNL43_RS08830	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
DNL43_RS08835	COG1956	GAF domain-containing protein
DNL43_RS08840	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
DNL43_RS08845	COG1104	cysteine desulfurase activity
DNL43_RS08850	COG0301	tRNA thio-modification
DNL43_RS08855	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
DNL43_RS08860	COG0525	valine-tRNA ligase activity
DNL43_RS08865	COG0285	dihydrofolate synthase activity
DNL43_RS08870	COG1077	Cell shape determining protein MreB Mrl
DNL43_RS08875	COG1792	Involved in formation and maintenance of cell shape
DNL43_RS08880	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
DNL43_RS08890	COG2894	cell division
DNL43_RS08900	COG0765	amino acid transport
DNL43_RS08905	COG1126	abc transporter atp-binding protein
DNL43_RS08910	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DNL43_RS08920	COG0612	Peptidase, M16
DNL43_RS08930	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DNL43_RS08935	COG1546	Belongs to the CinA family
DNL43_RS08935	COG1058	Belongs to the CinA family
DNL43_RS08940	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
DNL43_RS08945	COG1418	mRNA catabolic process
DNL43_RS08950	COG1692	metallophosphoesterase
DNL43_RS08955	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
DNL43_RS08960	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
DNL43_RS08965	COG0632	four-way junction helicase activity
DNL43_RS08970	COG2255	four-way junction helicase activity
DNL43_RS08990	COG0343	queuine tRNA-ribosyltransferase activity
DNL43_RS08995	COG1862	Preprotein translocase
DNL43_RS09000	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DNL43_RS09005	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
DNL43_RS09010	COG0513	Belongs to the DEAD box helicase family
DNL43_RS09015	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DNL43_RS09020	COG4472	Bacterial protein of unknown function (DUF965)
DNL43_RS09030	COG3906	Belongs to the UPF0473 family
DNL43_RS09040	COG1286	toxin biosynthetic process
DNL43_RS09045	COG1193	negative regulation of DNA recombination
DNL43_RS09050	COG3118	belongs to the thioredoxin family
DNL43_RS09055	COG1719	4-vinyl reductase, 4VR
DNL43_RS09060	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
DNL43_RS09065	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
DNL43_RS09080	COG0668	transmembrane transport
DNL43_RS09095	COG0006	proline dipeptidase activity
DNL43_RS09100	COG1609	Transcriptional regulator
DNL43_RS09105	COG0217	transcriptional regulatory protein
DNL43_RS09110	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DNL43_RS09120	COG4537	Required for transformation and DNA binding
DNL43_RS09145	COG0827	DNA restriction-modification system
DNL43_RS09155	COG1113	amino acid transport
DNL43_RS09165	COG0737	Belongs to the 5'-nucleotidase family
DNL43_RS09170	COG4470	Protein conserved in bacteria
DNL43_RS09175	COG0647	UMP catabolic process
DNL43_RS09195	COG3425	synthase
DNL43_RS09200	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DNL43_RS09205	COG4224	UPF0291 protein
DNL43_RS09210	COG3763	UPF0154 protein
DNL43_RS09215	COG0204	Acyl-transferase
DNL43_RS09220	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
DNL43_RS09225	COG2827	Endonuclease containing a URI domain
DNL43_RS09230	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DNL43_RS09240	COG0052	Belongs to the universal ribosomal protein uS2 family
DNL43_RS09245	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
DNL43_RS09255	COG0528	UMP kinase activity
DNL43_RS09260	COG0233	cytoplasmic translational termination
DNL43_RS09270	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DNL43_RS09275	COG4589	Belongs to the CDS family
DNL43_RS09280	COG0750	zinc metalloprotease
DNL43_RS09285	COG0442	prolyl-tRNA aminoacylation
DNL43_RS09290	COG2176	DNA-directed DNA polymerase activity
DNL43_RS09295	COG0779	Required for maturation of 30S ribosomal subunits
DNL43_RS09300	COG0195	Participates in both transcription termination and antitermination
DNL43_RS09305	COG2740	Nucleic-acid-binding protein implicated in transcription termination
DNL43_RS09315	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DNL43_RS09320	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
DNL43_RS09325	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DNL43_RS09330	COG0196	riboflavin kinase activity
DNL43_RS09335	COG1420	regulation of RNA biosynthetic process
DNL43_RS09350	COG0484	heat shock protein binding
DNL43_RS09355	COG0481	GTPase activity
DNL43_RS09375	COG2264	protein methyltransferase activity
DNL43_RS09380	COG1385	rRNA (uridine-N3-)-methyltransferase activity
DNL43_RS09385	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DNL43_RS09390	COG1490	D-aminoacyl-tRNA deacylase activity
DNL43_RS09400	COG0860	N-Acetylmuramoyl-L-alanine amidase
DNL43_RS09400	COG2247	cell wall binding repeat
DNL43_RS09405	COG0124	histidyl-tRNA synthetase
DNL43_RS09410	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
DNL43_RS09415	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DNL43_RS09420	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
DNL43_RS09425	COG1682	transport, permease protein
DNL43_RS09430	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
DNL43_RS09435	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
DNL43_RS09440	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
DNL43_RS09445	COG0828	Belongs to the bacterial ribosomal protein bS21 family
DNL43_RS09450	COG1610	YqeY-like protein
DNL43_RS09455	COG1702	phosphate starvation-inducible protein PhoH
DNL43_RS09460	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
DNL43_RS09465	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
DNL43_RS09470	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
DNL43_RS09475	COG1381	Involved in DNA repair and RecF pathway recombination
DNL43_RS09480	COG0752	glycyl-tRNA synthetase alpha subunit
DNL43_RS09485	COG0751	glycine-tRNA ligase activity
DNL43_RS09490	COG0358	DNA primase activity
DNL43_RS09495	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DNL43_RS09500	COG2384	SAM-dependent methyltransferase
DNL43_RS09505	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
DNL43_RS09515	COG0542	response to heat
DNL43_RS09530	COG0587	DNA-directed DNA polymerase activity
DNL43_RS09540	COG2996	Protein conserved in bacteria
DNL43_RS09555	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
DNL43_RS09560	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
DNL43_RS09565	COG1187	pseudouridine synthase activity
DNL43_RS09570	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
DNL43_RS09580	COG0514	ATP-dependent DNA helicase (RecQ)
DNL43_RS09590	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
DNL43_RS09595	COG0539	negative regulation of cytoplasmic translation
DNL43_RS09600	COG1160	GTP binding
DNL43_RS09610	COG0457	Tetratricopeptide repeat
DNL43_RS09615	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DNL43_RS09620	COG0617	tRNA 3'-terminal CCA addition
DNL43_RS09625	COG0488	(ABC) transporter
DNL43_RS09630	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
DNL43_RS09635	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
DNL43_RS09640	COG1307	EDD domain protein, DegV family
DNL43_RS09645	COG2755	lipolytic protein G-D-S-L family
DNL43_RS09660	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
DNL43_RS09670	COG0758	DNA mediated transformation
DNL43_RS09675	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DNL43_RS09680	COG4690	dipeptidase activity
DNL43_RS09690	COG1942	4-Oxalocrotonate Tautomerase
DNL43_RS09695	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DNL43_RS09700	COG0561	phosphatase activity
DNL43_RS09705	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
DNL43_RS09705	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DNL43_RS09710	COG1304	FMN binding
DNL43_RS09730	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DNL43_RS09730	COG1199	ATP-dependent helicase activity
DNL43_RS09745	COG0017	Asparaginyl-tRNA synthetase
DNL43_RS09760	COG3331	DNA recombination
DNL43_RS09765	COG4474	Belongs to the UPF0398 family
DNL43_RS09770	COG3599	regulation of cell shape
DNL43_RS09780	COG0116	Belongs to the methyltransferase superfamily
DNL43_RS09785	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DNL43_RS09790	COG0328	RNA-DNA hybrid ribonuclease activity
DNL43_RS09805	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
DNL43_RS09810	COG0564	pseudouridine synthase activity
DNL43_RS09815	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
DNL43_RS09820	COG0505	Belongs to the CarA family
DNL43_RS09840	COG1307	EDD domain protein, DegV family
DNL43_RS09845	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
DNL43_RS09855	COG0302	gtp cyclohydrolase
DNL43_RS09855	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
DNL43_RS09860	COG0285	dihydrofolate synthase activity
DNL43_RS09865	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
DNL43_RS09870	COG1051	belongs to the nudix hydrolase family
DNL43_RS09880	COG4974	Belongs to the 'phage' integrase family
DNL43_RS09885	COG1194	a g-specific adenine glycosylase
DNL43_RS09895	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DNL43_RS09905	COG1227	inorganic diphosphatase activity
DNL43_RS09910	COG0583	DNA-binding transcription factor activity
DNL43_RS09920	COG0187	DNA topoisomerase II activity
DNL43_RS09925	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
DNL43_RS09935	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
DNL43_RS09940	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
DNL43_RS09945	COG4974	Belongs to the 'phage' integrase family
DNL43_RS09950	COG0335	large ribosomal subunit rRNA binding
DNL43_RS09955	COG0336	Belongs to the RNA methyltransferase TrmD family
DNL43_RS09960	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
DNL43_RS09965	COG1837	Belongs to the UPF0109 family
DNL43_RS09970	COG0228	four-way junction DNA binding
DNL43_RS09975	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DNL43_RS09980	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
DNL43_RS09985	COG0552	protein localization to endoplasmic reticulum
DNL43_RS09990	COG1196	nuclear chromosome segregation
DNL43_RS09995	COG0571	ribonuclease III activity
DNL43_RS10000	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DNL43_RS10005	COG0416	fatty acid biosynthetic process
DNL43_RS10010	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DNL43_RS10015	COG1461	Dihydroxyacetone kinase
DNL43_RS10020	COG1302	Protein conserved in bacteria
DNL43_RS10025	COG0227	Belongs to the bacterial ribosomal protein bL28 family
DNL43_RS10030	COG2826	transposase and inactivated derivatives, IS30 family
DNL43_RS10035	COG1564	THIamine pyrophosphokinase
DNL43_RS10040	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DNL43_RS10045	COG1162	GTPase activity
DNL43_RS10050	COG2815	serine threonine protein kinase
DNL43_RS10050	COG0515	serine threonine protein kinase
DNL43_RS10055	COG0631	protein serine/threonine phosphatase activity
DNL43_RS10060	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DNL43_RS10060	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DNL43_RS10065	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DNL43_RS10070	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DNL43_RS10075	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DNL43_RS10080	COG1758	RNA polymerase activity
DNL43_RS10085	COG0194	GDP metabolic process
DNL43_RS10095	COG0497	DNA recombination
DNL43_RS10100	COG1438	arginine binding
DNL43_RS10105	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
DNL43_RS10115	COG1722	exodeoxyribonuclease VII activity
DNL43_RS10120	COG1570	exodeoxyribonuclease VII activity
DNL43_RS10125	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
DNL43_RS10130	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DNL43_RS10135	COG1302	Protein conserved in bacteria
DNL43_RS10140	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DNL43_RS10145	COG0211	Belongs to the bacterial ribosomal protein bL27 family
DNL43_RS10155	COG0261	This protein binds to 23S rRNA in the presence of protein L20
DNL43_RS10180	COG4166	transmembrane transport
DNL43_RS10190	COG0789	Transcriptional regulator
DNL43_RS10195	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
DNL43_RS10200	COG0584	glycerophosphoryl diester phosphodiesterase
DNL43_RS10210	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DNL43_RS10215	COG1940	carbohydrate kinase activity
DNL43_RS10225	COG0705	Rhomboid family
DNL43_RS10225	COG0457	Tetratricopeptide repeat
DNL43_RS10230	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DNL43_RS10235	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DNL43_RS10240	COG0768	penicillin binding
DNL43_RS10255	COG4841	protein insertion into membrane
DNL43_RS10260	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DNL43_RS10265	COG0572	uridine kinase
DNL43_RS10270	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
DNL43_RS10275	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DNL43_RS10275	COG0072	phenylalanine-tRNA ligase activity
DNL43_RS10280	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
DNL43_RS10285	COG1733	regulation of RNA biosynthetic process
DNL43_RS10295	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DNL43_RS10305	COG0706	membrane insertase activity
DNL43_RS10310	COG0475	glutathione-regulated potassium exporter activity
DNL43_RS10310	COG0569	domain protein
DNL43_RS10320	COG0745	RESPONSE REGULATOR receiver
DNL43_RS10325	COG1064	alcohol dehydrogenase
DNL43_RS10340	COG1323	Belongs to the UPF0348 family
DNL43_RS10345	COG2226	methyltransferase
DNL43_RS10350	COG0799	negative regulation of ribosome biogenesis
DNL43_RS10360	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
DNL43_RS10365	COG1534	Rna-binding protein
DNL43_RS10370	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
DNL43_RS10375	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
DNL43_RS10380	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
DNL43_RS10385	COG0291	Belongs to the bacterial ribosomal protein bL35 family
DNL43_RS10390	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
DNL43_RS10395	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DNL43_RS10400	COG1484	DNA-dependent DNA replication
DNL43_RS10410	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DNL43_RS10415	COG0237	dephospho-CoA kinase activity
DNL43_RS10420	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DNL43_RS10430	COG0670	Belongs to the BI1 family
DNL43_RS10435	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DNL43_RS10440	COG1674	ftsk spoiiie
DNL43_RS10445	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DNL43_RS10450	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DNL43_RS10460	COG0220	tRNA (guanine-N7-)-methyltransferase activity
DNL43_RS10470	COG1131	(ABC) transporter
DNL43_RS10475	COG0537	adenosine 5'-monophosphoramidase activity
DNL43_RS10485	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DNL43_RS10495	COG4717	serine-type aminopeptidase activity
DNL43_RS10500	COG0420	3'-5' exonuclease activity
DNL43_RS10510	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DNL43_RS10515	COG0018	arginyl-trna synthetase
DNL43_RS10545	COG0367	asparagine synthase
DNL43_RS10575	COG1846	Transcriptional regulator
DNL43_RS10585	COG0446	pyridine nucleotide-disulphide oxidoreductase
DNL43_RS10590	COG1937	Protein conserved in bacteria
DNL43_RS10600	COG0791	NLP P60 protein
DNL43_RS10605	COG4948	Mandelate Racemase Muconate Lactonizing
DNL43_RS10610	COG4166	transmembrane transport
DNL43_RS10645	COG1970	mechanosensitive ion channel activity
DNL43_RS10650	COG1554	hydrolase, family 65, central catalytic
DNL43_RS10655	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DNL43_RS10660	COG0561	phosphatase activity
DNL43_RS10665	COG1428	Deoxynucleoside kinase
DNL43_RS10680	COG0589	response to stress
DNL43_RS10690	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
DNL43_RS10695	COG2244	polysaccharide biosynthetic process
DNL43_RS10710	COG0495	leucyl-tRNA aminoacylation
DNL43_RS10715	COG0671	phosphoesterase, PA-phosphatase related
DNL43_RS10720	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
DNL43_RS10740	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
DNL43_RS10760	COG1113	amino acid transport
DNL43_RS10765	COG1335	isochorismatase
DNL43_RS10785	COG1302	Protein conserved in bacteria
DNL43_RS10800	COG2261	transglycosylase associated protein
DNL43_RS10815	COG3475	LICD family
DNL43_RS10845	COG1134	teichoic acid transport
DNL43_RS10850	COG1388	LysM domain
DNL43_RS10850	COG1705	Flagellar rod assembly protein muramidase FlgJ
DNL43_RS10860	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DNL43_RS10875	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
DNL43_RS10885	COG2365	Tyrosine phosphatase family
DNL43_RS10890	COG0025	NhaP-type Na H and K H
DNL43_RS10895	COG0812	UDP-N-acetylmuramate dehydrogenase activity
DNL43_RS10900	COG2176	DNA-directed DNA polymerase activity
DNL43_RS10905	COG1247	-acetyltransferase
DNL43_RS10910	COG0802	atpase or kinase
DNL43_RS10915	COG0280	phosphate acetyltransferase
DNL43_RS10920	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
DNL43_RS10930	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
DNL43_RS10935	COG0557	exoribonuclease II activity
DNL43_RS10945	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DNL43_RS10950	COG0038	chloride channel
DNL43_RS10965	COG0148	phosphopyruvate hydratase activity
DNL43_RS10970	COG0149	triose-phosphate isomerase activity
DNL43_RS10990	COG0346	lactoylglutathione lyase activity
DNL43_RS10995	COG0740	serine-type endopeptidase activity
DNL43_RS11010	COG1481	regulation of sporulation
DNL43_RS11020	COG1660	Displays ATPase and GTPase activities
DNL43_RS11025	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DNL43_RS11030	COG0556	nucleotide-excision repair
DNL43_RS11040	COG0492	ferredoxin-NADP+ reductase activity
DNL43_RS11045	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DNL43_RS11050	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
DNL43_RS11055	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
DNL43_RS11060	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
DNL43_RS11065	COG1950	PFAM Membrane protein of
DNL43_RS11075	COG0704	Plays a role in the regulation of phosphate uptake
DNL43_RS11080	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DNL43_RS11085	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DNL43_RS11090	COG0581	inorganic phosphate transmembrane transporter activity
DNL43_RS11095	COG0573	inorganic phosphate transmembrane transporter activity
DNL43_RS11105	COG5002	protein histidine kinase activity
DNL43_RS11110	COG0745	RESPONSE REGULATOR receiver
DNL43_RS11115	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DNL43_RS11125	COG0653	protein targeting
DNL43_RS11140	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
DNL43_RS11145	COG1739	Uncharacterized protein family UPF0029
DNL43_RS11150	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DNL43_RS11155	COG1380	Effector of murein hydrolase LrgA
DNL43_RS11160	COG1346	cytolysis
DNL43_RS11165	COG0531	amino acid
DNL43_RS11175	COG0459	protein refolding
DNL43_RS11180	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
DNL43_RS11185	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
DNL43_RS11190	COG0488	(ABC) transporter
DNL43_RS11195	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DNL43_RS11200	COG0456	acetyltransferase
DNL43_RS11205	COG1214	PFAM Peptidase M22, glycoprotease
DNL43_RS11220	COG4467	Involved in initiation control of chromosome replication
DNL43_RS11230	COG3870	Protein conserved in bacteria
DNL43_RS11235	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DNL43_RS11250	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
DNL43_RS11255	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
DNL43_RS11270	COG2813	Specifically methylates the guanine in position
DNL43_RS11275	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
DNL43_RS11280	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DNL43_RS11285	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DNL43_RS11295	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
DNL43_RS11300	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DNL43_RS11305	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
DNL43_RS11310	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
DNL43_RS11310	COG0392	lysyltransferase activity
DNL43_RS11315	COG0222	ribosome binding
DNL43_RS11320	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
DNL43_RS11325	COG0081	regulation of translation
DNL43_RS11330	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
DNL43_RS11340	COG0250	Participates in transcription elongation, termination and antitermination
DNL43_RS11345	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DNL43_RS11350	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DNL43_RS11365	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DNL43_RS11370	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
DNL43_RS11375	COG0215	cysteine-tRNA ligase activity
DNL43_RS11380	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DNL43_RS11385	COG4956	integral membrane protein (PIN domain superfamily)
DNL43_RS11390	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
DNL43_RS11395	COG0756	dUTP diphosphatase activity
DNL43_RS11400	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
DNL43_RS11410	COG0588	phosphoglycerate mutase activity
DNL43_RS11420	COG1316	TRANSCRIPTIONal
DNL43_RS11425	COG3716	PTS system mannose fructose sorbose family IID component
DNL43_RS11440	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DNL43_RS11440	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
DNL43_RS11445	COG0546	phosphoglycolate phosphatase activity
DNL43_RS11455	COG0083	homoserine kinase activity
DNL43_RS11460	COG3091	SprT-like family
DNL43_RS11465	COG2183	response to ionizing radiation
DNL43_RS11485	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
DNL43_RS11500	COG0519	Catalyzes the synthesis of GMP from XMP
DNL43_RS11505	COG2188	Transcriptional regulator
DNL43_RS11510	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
DNL43_RS11515	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DNL43_RS11535	COG3104	oligopeptide transport
DNL43_RS11620	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
DNL43_RS11655	COG2261	transglycosylase associated protein
DNL43_RS11665	COG4975	Glucose uptake
DNL43_RS11680	COG0662	Cupin 2, conserved barrel domain protein
DNL43_RS11710	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DNL43_RS11760	COG1192	Involved in chromosome partitioning
DNL43_RS11775	COG2207	Transcriptional regulator
DNL43_RS11865	COG0367	asparagine synthase
DNL43_RS11910	COG4876	unkown
DNL43_RS11925	COG0028	Belongs to the TPP enzyme family
DNL43_RS11930	COG2261	transglycosylase associated protein
DNL43_RS11940	COG2801	Transposase and inactivated derivatives
DNL43_RS11970	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis