locus-tag	class	description
FAM21731_RS00005	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
FAM21731_RS00010	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
FAM21731_RS00030	COG2818	Glycosylase
FAM21731_RS00040	COG1181	Belongs to the D-alanine--D-alanine ligase family
FAM21731_RS00050	COG1131	(ABC) transporter
FAM21731_RS00055	COG1725	Transcriptional regulator
FAM21731_RS00065	COG1136	(ABC) transporter
FAM21731_RS00075	COG1464	Belongs to the NlpA lipoprotein family
FAM21731_RS00080	COG2011	ABC-type metal ion transport system permease component
FAM21731_RS00085	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FAM21731_RS00095	COG0772	Belongs to the SEDS family
FAM21731_RS00105	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
FAM21731_RS00110	COG1077	Cell shape determining protein MreB Mrl
FAM21731_RS00115	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FAM21731_RS00120	COG4836	Membrane
FAM21731_RS00125	COG0355	proton-transporting ATP synthase activity, rotational mechanism
FAM21731_RS00130	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
FAM21731_RS00135	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
FAM21731_RS00145	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FAM21731_RS00150	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
FAM21731_RS00155	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FAM21731_RS00160	COG0356	it plays a direct role in the translocation of protons across the membrane
FAM21731_RS00165	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
FAM21731_RS00170	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FAM21731_RS00175	COG0009	L-threonylcarbamoyladenylate synthase
FAM21731_RS00180	COG2890	protein-(glutamine-N5) methyltransferase activity
FAM21731_RS00185	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
FAM21731_RS00190	COG1435	thymidine kinase activity
FAM21731_RS00195	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
FAM21731_RS00200	COG3442	glutamine amidotransferase
FAM21731_RS00205	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
FAM21731_RS00220	COG2315	Protein conserved in bacteria
FAM21731_RS00240	COG3850	Histidine kinase
FAM21731_RS00240	COG5002	protein histidine kinase activity
FAM21731_RS00245	COG0745	RESPONSE REGULATOR receiver
FAM21731_RS00255	COG0561	phosphatase activity
FAM21731_RS00280	COG0028	Belongs to the TPP enzyme family
FAM21731_RS00310	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
FAM21731_RS00315	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FAM21731_RS00315	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FAM21731_RS00320	COG0307	riboflavin synthase, alpha
FAM21731_RS00325	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FAM21731_RS00325	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FAM21731_RS00340	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
FAM21731_RS00350	COG1892	Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four- carbon dicarboxylic acid source for the tricarboxylic acid cycle
FAM21731_RS00380	COG1902	pentaerythritol trinitrate reductase activity
FAM21731_RS00400	COG2814	Major facilitator Superfamily
FAM21731_RS00405	COG1012	belongs to the aldehyde dehydrogenase family
FAM21731_RS00415	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FAM21731_RS00440	COG1846	Transcriptional regulator
FAM21731_RS00445	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
FAM21731_RS00455	COG1027	Aspartate ammonia-lyase
FAM21731_RS00480	COG1033	growth of symbiont in host cell
FAM21731_RS00480	COG2409	Drug exporters of the RND superfamily
FAM21731_RS00505	COG2153	protein acetylation
FAM21731_RS00510	COG2848	UPF0210 protein
FAM21731_RS00515	COG3830	Belongs to the UPF0237 family
FAM21731_RS00520	COG0110	maltose O-acetyltransferase activity
FAM21731_RS00535	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FAM21731_RS00550	COG0436	Aminotransferase
FAM21731_RS00555	COG0765	amino acid transport
FAM21731_RS00560	COG1126	abc transporter atp-binding protein
FAM21731_RS00680	COG0539	negative regulation of cytoplasmic translation
FAM21731_RS00685	COG0586	Pfam SNARE associated Golgi protein
FAM21731_RS00695	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FAM21731_RS00700	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
FAM21731_RS00700	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
FAM21731_RS00710	COG1234	tRNA 3'-trailer cleavage
FAM21731_RS00725	COG2755	lipolytic protein G-D-S-L family
FAM21731_RS00725	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
FAM21731_RS00730	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
FAM21731_RS00735	COG0322	excinuclease ABC activity
FAM21731_RS00740	COG1126	abc transporter atp-binding protein
FAM21731_RS00745	COG0765	amino acid transport
FAM21731_RS00750	COG0165	Argininosuccinate lyase
FAM21731_RS00755	COG0137	argininosuccinate synthase activity
FAM21731_RS00765	COG0218	Necessary for normal cell division and for the maintenance of normal septation
FAM21731_RS00770	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
FAM21731_RS00775	COG0544	peptidyl-prolyl cis-trans isomerase activity
FAM21731_RS00780	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FAM21731_RS00795	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
FAM21731_RS00800	COG0268	Binds directly to 16S ribosomal RNA
FAM21731_RS00805	COG1466	dna polymerase III delta subunit
FAM21731_RS00810	COG0658	competence protein
FAM21731_RS00810	COG2333	competence protein COMEC
FAM21731_RS00815	COG2131	deaminase
FAM21731_RS00820	COG1555	photosystem II stabilization
FAM21731_RS00825	COG3480	Lon protease (S16) C-terminal proteolytic domain
FAM21731_RS00830	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
FAM21731_RS00835	COG0742	ribosomal rna small subunit methyltransferase
FAM21731_RS00845	COG0772	Belongs to the SEDS family
FAM21731_RS00850	COG1217	gtp-binding protein TYPA
FAM21731_RS00855	COG0483	inositol monophosphate 1-phosphatase activity
FAM21731_RS00860	COG4476	Belongs to the UPF0223 family
FAM21731_RS00885	COG0242	peptide deformylase activity
FAM21731_RS00900	COG5503	Protein of unknown function (DUF1447)
FAM21731_RS00910	COG1597	lipid kinase activity
FAM21731_RS00935	COG0667	Aldo Keto reductase
FAM21731_RS00940	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FAM21731_RS00945	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FAM21731_RS00960	COG0482	sulfurtransferase activity
FAM21731_RS00965	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FAM21731_RS00980	COG0107	imidazoleglycerol-phosphate synthase activity
FAM21731_RS00985	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
FAM21731_RS01000	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
FAM21731_RS01010	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
FAM21731_RS01015	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FAM21731_RS01020	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FAM21731_RS01030	COG1104	cysteine desulfurase activity
FAM21731_RS01050	COG1278	Cold shock
FAM21731_RS01055	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
FAM21731_RS01060	COG3599	regulation of cell shape
FAM21731_RS01065	COG2302	S4 RNA-binding domain
FAM21731_RS01075	COG1799	cell septum assembly
FAM21731_RS01090	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
FAM21731_RS01095	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FAM21731_RS01100	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
FAM21731_RS01105	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FAM21731_RS01110	COG0768	penicillin binding
FAM21731_RS01120	COG0275	rRNA processing
FAM21731_RS01125	COG2001	Belongs to the MraZ family
FAM21731_RS01140	COG1674	ftsk spoiiie
FAM21731_RS01150	COG0500	methyltransferase
FAM21731_RS01155	COG0564	pseudouridine synthase activity
FAM21731_RS01160	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
FAM21731_RS01165	COG2357	RelA SpoT domain protein
FAM21731_RS01190	COG5002	protein histidine kinase activity
FAM21731_RS01195	COG0745	RESPONSE REGULATOR receiver
FAM21731_RS01205	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
FAM21731_RS01210	COG0463	Glycosyl transferase, family 2
FAM21731_RS01215	COG4862	establishment of competence for transformation
FAM21731_RS01220	COG1393	Belongs to the ArsC family
FAM21731_RS01225	COG1234	tRNA 3'-trailer cleavage
FAM21731_RS01345	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FAM21731_RS01360	COG0789	Transcriptional regulator
FAM21731_RS01370	COG2084	Dehydrogenase
FAM21731_RS01390	COG0626	cystathionine gamma-synthase activity
FAM21731_RS01400	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
FAM21731_RS01405	COG2814	Major facilitator Superfamily
FAM21731_RS01420	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
FAM21731_RS01425	COG1272	protein, Hemolysin III
FAM21731_RS01445	COG1312	Catalyzes the dehydration of D-mannonate
FAM21731_RS01455	COG1686	Belongs to the peptidase S11 family
FAM21731_RS01470	COG2801	Transposase and inactivated derivatives
FAM21731_RS01505	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
FAM21731_RS01530	COG2211	Major facilitator Superfamily
FAM21731_RS01545	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FAM21731_RS01560	COG0477	Major facilitator Superfamily
FAM21731_RS01595	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FAM21731_RS01600	COG0800	Aldolase
FAM21731_RS01605	COG1312	Catalyzes the dehydration of D-mannonate
FAM21731_RS01610	COG1802	Transcriptional regulator
FAM21731_RS01635	COG3250	beta-galactosidase activity
FAM21731_RS01665	COG2233	PERMEase
FAM21731_RS01675	COG1278	Cold shock
FAM21731_RS01685	COG0110	maltose O-acetyltransferase activity
FAM21731_RS01690	COG0531	amino acid
FAM21731_RS01695	COG0588	phosphoglycerate mutase activity
FAM21731_RS01700	COG0628	permease
FAM21731_RS01725	COG1686	Belongs to the peptidase S11 family
FAM21731_RS01735	COG0745	RESPONSE REGULATOR receiver
FAM21731_RS01745	COG4716	Myosin-crossreactive antigen
FAM21731_RS01750	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
FAM21731_RS01765	COG0516	GMP reductase activity
FAM21731_RS01765	COG0517	IMP dehydrogenase activity
FAM21731_RS01775	COG0012	GTP binding
FAM21731_RS01780	COG4481	Protein conserved in bacteria
FAM21731_RS01785	COG1475	DNA binding
FAM21731_RS01790	COG1192	Involved in chromosome partitioning
FAM21731_RS01795	COG0357	Ribosomal RNA small subunit methyltransferase G
FAM21731_RS01800	COG2195	Cleaves the N-terminal amino acid of tripeptides
FAM21731_RS01805	COG4166	transmembrane transport
FAM21731_RS01820	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FAM21731_RS01825	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
FAM21731_RS01880	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
FAM21731_RS01915	COG4166	transmembrane transport
FAM21731_RS01960	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
FAM21731_RS02005	COG3760	aminoacyl-tRNA metabolism involved in translational fidelity
FAM21731_RS02015	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FAM21731_RS02030	COG0791	NLP P60 protein
FAM21731_RS02055	COG1307	EDD domain protein, DegV family
FAM21731_RS02065	COG0577	efflux transmembrane transporter activity
FAM21731_RS02065	COG1136	(ABC) transporter
FAM21731_RS02115	COG0352	thiamine-phosphate diphosphorylase activity
FAM21731_RS02120	COG0351	phosphomethylpyrimidine kinase
FAM21731_RS02125	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
FAM21731_RS02130	COG0300	oxidoreductase activity
FAM21731_RS02140	COG0656	L-ascorbic acid biosynthetic process
FAM21731_RS02145	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FAM21731_RS02155	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
FAM21731_RS02210	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
FAM21731_RS02220	COG0516	GMP reductase activity
FAM21731_RS02235	COG1757	Na H antiporter
FAM21731_RS02250	COG3118	belongs to the thioredoxin family
FAM21731_RS02255	COG0861	Integral membrane protein TerC family
FAM21731_RS02260	COG1705	Flagellar rod assembly protein muramidase FlgJ
FAM21731_RS02300	COG0406	alpha-ribazole phosphatase activity
FAM21731_RS02305	COG1368	sulfuric ester hydrolase activity
FAM21731_RS02320	COG0492	ferredoxin-NADP+ reductase activity
FAM21731_RS02350	COG1393	Belongs to the ArsC family
FAM21731_RS02355	COG0025	NhaP-type Na H and K H
FAM21731_RS02360	COG0737	Belongs to the 5'-nucleotidase family
FAM21731_RS02370	COG1418	mRNA catabolic process
FAM21731_RS02380	COG1396	sequence-specific DNA binding
FAM21731_RS02390	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FAM21731_RS02405	COG0546	phosphoglycolate phosphatase activity
FAM21731_RS02445	COG1438	arginine binding
FAM21731_RS02465	COG0583	DNA-binding transcription factor activity
FAM21731_RS02470	COG2233	PERMEase
FAM21731_RS02485	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FAM21731_RS02490	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
FAM21731_RS02495	COG0586	Pfam SNARE associated Golgi protein
FAM21731_RS02500	COG4989	oxidoreductase activity
FAM21731_RS02515	COG1028	Short-chain dehydrogenase reductase Sdr
FAM21731_RS02520	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
FAM21731_RS02535	COG0488	(ABC) transporter
FAM21731_RS02555	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FAM21731_RS02565	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
FAM21731_RS02575	COG1215	transferase activity, transferring glycosyl groups
FAM21731_RS02590	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FAM21731_RS02615	COG1131	(ABC) transporter
FAM21731_RS02620	COG0656	L-ascorbic acid biosynthetic process
FAM21731_RS02630	COG2814	Major facilitator Superfamily
FAM21731_RS02645	COG0656	L-ascorbic acid biosynthetic process
FAM21731_RS02655	COG0509	glycine decarboxylation via glycine cleavage system
FAM21731_RS02660	COG0095	Lipoate-protein ligase
FAM21731_RS02665	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
FAM21731_RS02670	COG0509	glycine decarboxylation via glycine cleavage system
FAM21731_RS02680	COG0519	Catalyzes the synthesis of GMP from XMP
FAM21731_RS02690	COG1376	ErfK ybiS ycfS ynhG family protein
FAM21731_RS02705	COG2936	dipeptidyl-peptidase activity
FAM21731_RS02720	COG4221	oxidoreductase activity
FAM21731_RS02740	COG0583	DNA-binding transcription factor activity
FAM21731_RS02780	COG0667	Aldo Keto reductase
FAM21731_RS02800	COG0656	L-ascorbic acid biosynthetic process
FAM21731_RS02820	COG1522	sequence-specific DNA binding
FAM21731_RS02825	COG1113	amino acid transport
FAM21731_RS02835	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FAM21731_RS02840	COG0167	dihydroorotate dehydrogenase activity
FAM21731_RS02845	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
FAM21731_RS02850	COG0284	orotidine-5'-phosphate decarboxylase activity
FAM21731_RS02855	COG2814	Major facilitator Superfamily
FAM21731_RS02870	COG3022	response to hydroperoxide
FAM21731_RS02875	COG0151	Belongs to the GarS family
FAM21731_RS02880	COG0138	bifunctional purine biosynthesis protein purh
FAM21731_RS02885	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
FAM21731_RS02900	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FAM21731_RS02910	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FAM21731_RS02915	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
FAM21731_RS02920	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
FAM21731_RS02925	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
FAM21731_RS02930	COG2814	Major facilitator Superfamily
FAM21731_RS02935	COG0667	Aldo Keto reductase
FAM21731_RS02965	COG0004	ammonium transporteR
FAM21731_RS02985	COG2807	transmembrane transport
FAM21731_RS02990	COG1012	belongs to the aldehyde dehydrogenase family
FAM21731_RS02995	COG2814	Major facilitator Superfamily
FAM21731_RS03005	COG1914	H( )-stimulated, divalent metal cation uptake system
FAM21731_RS03030	COG1960	acyl-CoA dehydrogenase activity
FAM21731_RS03035	COG2086	electron transfer activity
FAM21731_RS03095	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
FAM21731_RS03100	COG1131	(ABC) transporter
FAM21731_RS03110	COG1309	transcriptional regulator
FAM21731_RS03125	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
FAM21731_RS03130	COG0436	Aminotransferase
FAM21731_RS03135	COG1393	Belongs to the ArsC family
FAM21731_RS03155	COG0248	Ppx GppA phosphatase
FAM21731_RS03160	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
FAM21731_RS03170	COG0667	Aldo Keto reductase
FAM21731_RS03195	COG0267	Belongs to the bacterial ribosomal protein bL33 family
FAM21731_RS03210	COG2957	Belongs to the agmatine deiminase family
FAM21731_RS03215	COG0318	PFAM AMP-dependent synthetase and ligase
FAM21731_RS03220	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
FAM21731_RS03225	COG2050	protein possibly involved in aromatic compounds catabolism
FAM21731_RS03230	COG1136	(ABC) transporter
FAM21731_RS03270	COG0438	transferase activity, transferring glycosyl groups
FAM21731_RS03340	COG0386	Belongs to the glutathione peroxidase family
FAM21731_RS03345	COG1132	(ABC) transporter
FAM21731_RS03355	COG0095	Lipoate-protein ligase
FAM21731_RS03370	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FAM21731_RS03385	COG0436	Aminotransferase
FAM21731_RS03390	COG2226	methyltransferase
FAM21731_RS03430	COG4166	transmembrane transport
FAM21731_RS03440	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
FAM21731_RS03445	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FAM21731_RS03450	COG2076	Multidrug Resistance protein
FAM21731_RS03475	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
FAM21731_RS03560	COG1307	EDD domain protein, DegV family
FAM21731_RS03570	COG0477	Major facilitator Superfamily
FAM21731_RS03580	COG2211	Major facilitator Superfamily
FAM21731_RS03580	COG2190	(PTS) system
FAM21731_RS03585	COG1609	Transcriptional regulator
FAM21731_RS03595	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
FAM21731_RS03600	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
FAM21731_RS03610	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
FAM21731_RS03615	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
FAM21731_RS03620	COG1605	Chorismate mutase
FAM21731_RS03620	COG0287	Prephenate dehydrogenase
FAM21731_RS03625	COG1228	amidohydrolase
FAM21731_RS03635	COG0726	polysaccharide deacetylase
FAM21731_RS03640	COG0710	3-dehydroquinate dehydratase activity
FAM21731_RS03645	COG0738	Major facilitator superfamily
FAM21731_RS03655	COG1126	abc transporter atp-binding protein
FAM21731_RS03660	COG0765	amino acid transport
FAM21731_RS03665	COG0765	amino acid transport
FAM21731_RS03670	COG0778	Nitroreductase
FAM21731_RS03700	COG1132	(ABC) transporter
FAM21731_RS03705	COG1132	(ABC) transporter
FAM21731_RS03715	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
FAM21731_RS03720	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
FAM21731_RS03730	COG1181	Belongs to the D-alanine--D-alanine ligase family
FAM21731_RS03730	COG2918	glutathione biosynthetic process
FAM21731_RS03735	COG0697	spore germination
FAM21731_RS03740	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
FAM21731_RS03745	COG4166	transmembrane transport
FAM21731_RS03765	COG3250	beta-galactosidase activity
FAM21731_RS03770	COG1609	Transcriptional regulator
FAM21731_RS03805	COG1335	isochorismatase
FAM21731_RS03810	COG1114	Component of the transport system for branched-chain amino acids
FAM21731_RS03815	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FAM21731_RS03835	COG0028	Belongs to the TPP enzyme family
FAM21731_RS03850	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
FAM21731_RS03865	COG2217	Heavy metal translocating P-type atpase
FAM21731_RS03870	COG0501	Belongs to the peptidase M48B family
FAM21731_RS03875	COG1704	LemA family
FAM21731_RS03885	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
FAM21731_RS03895	COG0477	Major facilitator Superfamily
FAM21731_RS03900	COG0436	Aminotransferase
FAM21731_RS03925	COG1215	transferase activity, transferring glycosyl groups
FAM21731_RS03930	COG3583	domain protein
FAM21731_RS03930	COG3525	Glycosyl hydrolase, family 20, catalytic domain
FAM21731_RS03930	COG3064	Membrane
FAM21731_RS03935	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
FAM21731_RS03940	COG1131	(ABC) transporter
FAM21731_RS03955	COG3527	Alpha-acetolactate decarboxylase
FAM21731_RS03960	COG1011	Hydrolase
FAM21731_RS03965	COG0477	Major facilitator Superfamily
FAM21731_RS03970	COG0783	Belongs to the Dps family
FAM21731_RS03975	COG0667	Aldo Keto reductase
FAM21731_RS03980	COG1053	succinate dehydrogenase
FAM21731_RS03990	COG3001	Fructosamine kinase
FAM21731_RS04000	COG2151	metal-sulfur cluster biosynthetic enzyme
FAM21731_RS04005	COG0719	Fe-S assembly protein
FAM21731_RS04015	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
FAM21731_RS04020	COG0719	Fe-S assembly protein
FAM21731_RS04030	COG0070	glutamate synthase
FAM21731_RS04030	COG0069	glutamate synthase activity
FAM21731_RS04030	COG0067	glutamate synthase
FAM21731_RS04035	COG0493	'glutamate synthase
FAM21731_RS04060	COG0667	Aldo Keto reductase
FAM21731_RS04065	COG4978	Transcriptional regulator
FAM21731_RS04065	COG0789	Transcriptional regulator
FAM21731_RS04085	COG1914	H( )-stimulated, divalent metal cation uptake system
FAM21731_RS04105	COG4166	transmembrane transport
FAM21731_RS04115	COG1132	(ABC) transporter
FAM21731_RS04125	COG0584	glycerophosphoryl diester phosphodiesterase
FAM21731_RS04135	COG0395	ABC-type sugar transport system, permease component
FAM21731_RS04140	COG1175	transmembrane transport
FAM21731_RS04170	COG0584	glycerophosphoryl diester phosphodiesterase
FAM21731_RS04200	COG0477	Major facilitator Superfamily
FAM21731_RS04205	COG0157	Belongs to the NadC ModD family
FAM21731_RS04215	COG1113	amino acid transport
FAM21731_RS04220	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FAM21731_RS04225	COG1573	uracil-dna glycosylase
FAM21731_RS04235	COG4166	transmembrane transport
FAM21731_RS04245	COG1288	antiporter activity
FAM21731_RS04250	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
FAM21731_RS04260	COG0702	epimerase
FAM21731_RS04270	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
FAM21731_RS04275	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
FAM21731_RS04285	COG1696	Membrane protein involved in D-alanine export
FAM21731_RS04290	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FAM21731_RS04345	COG0124	histidyl-tRNA synthetase
FAM21731_RS04365	COG2814	Major facilitator Superfamily
FAM21731_RS04370	COG1473	amidohydrolase
FAM21731_RS04375	COG4166	transmembrane transport
FAM21731_RS04405	COG1028	Short-chain dehydrogenase reductase Sdr
FAM21731_RS04430	COG2610	gluconate transmembrane transporter activity
FAM21731_RS04435	COG0800	Aldolase
FAM21731_RS04445	COG4948	Mandelate Racemase Muconate Lactonizing
FAM21731_RS04480	COG2188	Transcriptional regulator
FAM21731_RS04490	COG3069	C4-dicarboxylate transmembrane transporter activity
FAM21731_RS04500	COG0673	inositol 2-dehydrogenase activity
FAM21731_RS04510	COG1869	D-ribose catabolic process
FAM21731_RS04515	COG0738	Major facilitator superfamily
FAM21731_RS04520	COG2390	Transcriptional regulator
FAM21731_RS04525	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
FAM21731_RS04535	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FAM21731_RS04540	COG4166	transmembrane transport
FAM21731_RS04545	COG1506	peptidase
FAM21731_RS04545	COG4946	Tricorn protease homolog
FAM21731_RS04545	COG0823	Involved in the tonB-independent uptake of proteins
FAM21731_RS04550	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FAM21731_RS04555	COG1228	amidohydrolase
FAM21731_RS04560	COG1228	amidohydrolase
FAM21731_RS04590	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FAM21731_RS04595	COG1518	maintenance of DNA repeat elements
FAM21731_RS04610	COG1857	crispr-associated protein
FAM21731_RS04645	COG0095	Lipoate-protein ligase
FAM21731_RS04675	COG1414	Transcriptional regulator
FAM21731_RS04680	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
FAM21731_RS04685	COG1028	Short-chain dehydrogenase reductase Sdr
FAM21731_RS04690	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FAM21731_RS04695	COG0800	Aldolase
FAM21731_RS04700	COG1609	Transcriptional regulator
FAM21731_RS04705	COG1904	glucuronate isomerase
FAM21731_RS04720	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
FAM21731_RS04725	COG2211	Major facilitator Superfamily
FAM21731_RS04740	COG0028	Belongs to the TPP enzyme family
FAM21731_RS04745	COG3527	Alpha-acetolactate decarboxylase
FAM21731_RS04760	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FAM21731_RS04765	COG1028	Short-chain dehydrogenase reductase Sdr
FAM21731_RS04780	COG2706	6-phosphogluconolactonase activity
FAM21731_RS04785	COG1609	Transcriptional regulator
FAM21731_RS04795	COG1942	4-Oxalocrotonate Tautomerase
FAM21731_RS04800	COG1250	3-hydroxyacyl-CoA dehydrogenase
FAM21731_RS04825	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
FAM21731_RS04830	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
FAM21731_RS04845	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FAM21731_RS04850	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
FAM21731_RS04865	COG5002	protein histidine kinase activity
FAM21731_RS04870	COG0745	RESPONSE REGULATOR receiver
FAM21731_RS04880	COG1309	transcriptional regulator
FAM21731_RS04895	COG0305	Participates in initiation and elongation during chromosome replication
FAM21731_RS04900	COG0359	binds to the 23S rRNA
FAM21731_RS04910	COG1113	amino acid transport
FAM21731_RS04915	COG1757	Na H antiporter
FAM21731_RS04920	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
FAM21731_RS04925	COG0629	single-stranded DNA binding
FAM21731_RS04930	COG0360	Binds together with S18 to 16S ribosomal RNA
FAM21731_RS04935	COG1304	FMN binding
FAM21731_RS04950	COG0187	DNA topoisomerase II activity
FAM21731_RS04955	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FAM21731_RS04960	COG2501	S4 domain
FAM21731_RS04965	COG0592	DNA-directed DNA polymerase activity
FAM21731_RS04970	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FAM21731_RS04975	COG0230	Belongs to the bacterial ribosomal protein bL34 family
FAM21731_RS04980	COG0594	ribonuclease P activity
FAM21731_RS04985	COG0706	membrane insertase activity
FAM21731_RS04990	COG1929	Belongs to the glycerate kinase type-1 family
FAM21731_RS05010	COG1847	R3H domain protein
FAM21731_RS05015	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
FAM21731_RS05020	COG0445	tRNA wobble uridine modification
FAM21731_RS05025	COG2814	Major facilitator Superfamily
FAM21731_RS05030	COG0681	Belongs to the peptidase S26 family
FAM21731_RS05035	COG0588	phosphoglycerate mutase activity
FAM21731_RS05055	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FAM21731_RS05065	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FAM21731_RS05065	COG0512	Glutamine amidotransferase of anthranilate synthase
FAM21731_RS05075	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
FAM21731_RS05080	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
FAM21731_RS05100	COG0573	inorganic phosphate transmembrane transporter activity
FAM21731_RS05105	COG0581	inorganic phosphate transmembrane transporter activity
FAM21731_RS05115	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
FAM21731_RS05125	COG2130	NADP-dependent
FAM21731_RS05130	COG2814	Major facilitator Superfamily
FAM21731_RS05140	COG1472	Belongs to the glycosyl hydrolase 3 family
FAM21731_RS05175	COG1114	Component of the transport system for branched-chain amino acids
FAM21731_RS05200	COG2814	Major facilitator Superfamily
FAM21731_RS05205	COG0406	alpha-ribazole phosphatase activity
FAM21731_RS05220	COG0531	amino acid
FAM21731_RS05240	COG1968	undecaprenyl-diphosphatase activity
FAM21731_RS05245	COG0604	alcohol dehydrogenase
FAM21731_RS05275	COG0460	homoserine dehydrogenase
FAM21731_RS05280	COG0527	aspartate kinase activity
FAM21731_RS05285	COG0583	DNA-binding transcription factor activity
FAM21731_RS05295	COG0833	amino acid
FAM21731_RS05300	COG2040	homocysteine
FAM21731_RS05315	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
FAM21731_RS05320	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FAM21731_RS05330	COG2814	Major facilitator Superfamily
FAM21731_RS05335	COG1250	3-hydroxyacyl-CoA dehydrogenase
FAM21731_RS05360	COG1725	Transcriptional regulator
FAM21731_RS05365	COG1131	(ABC) transporter
FAM21731_RS05395	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
FAM21731_RS05400	COG0066	3-isopropylmalate dehydratase activity
FAM21731_RS05405	COG2271	Major facilitator Superfamily
FAM21731_RS05420	COG1373	ATPase (AAA superfamily
FAM21731_RS05425	COG0114	fumarate hydratase activity
FAM21731_RS05430	COG0281	malic enzyme
FAM21731_RS05435	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FAM21731_RS05440	COG2096	Adenosyltransferase
FAM21731_RS05445	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FAM21731_RS05455	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
FAM21731_RS05465	COG4152	abc transporter atp-binding protein
FAM21731_RS05470	COG1668	transmembrane transport
FAM21731_RS05490	COG3048	D-serine ammonia-lyase activity
FAM21731_RS05495	COG2814	Major facilitator Superfamily
FAM21731_RS05505	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
FAM21731_RS05520	COG4475	Protein of unknown function (DUF436)
FAM21731_RS05530	COG3579	cysteine-type endopeptidase activity
FAM21731_RS05545	COG1609	Transcriptional regulator
FAM21731_RS05550	COG2814	Major facilitator Superfamily
FAM21731_RS05570	COG3759	membrane
FAM21731_RS05575	COG0166	Belongs to the GPI family
FAM21731_RS05590	COG1063	alcohol dehydrogenase
FAM21731_RS05595	COG1940	carbohydrate kinase activity
FAM21731_RS05635	COG4608	Belongs to the ABC transporter superfamily
FAM21731_RS05640	COG0601	transmembrane transport
FAM21731_RS05665	COG1598	PFAM Uncharacterised protein family UPF0150
FAM21731_RS05690	COG2244	polysaccharide biosynthetic process
FAM21731_RS05715	COG0159	tryptophan synthase activity
FAM21731_RS05750	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FAM21731_RS05755	COG0477	Major facilitator Superfamily
FAM21731_RS05760	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FAM21731_RS05765	COG2357	RelA SpoT domain protein
FAM21731_RS05780	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FAM21731_RS05785	COG4708	membrane
FAM21731_RS05790	COG2252	PERMEase
FAM21731_RS05795	COG0667	Aldo Keto reductase
FAM21731_RS05815	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
FAM21731_RS05820	COG1074	ATP-dependent DNA helicase activity
FAM21731_RS05825	COG0626	cystathionine gamma-synthase activity
FAM21731_RS05840	COG3237	CsbD-like
FAM21731_RS05850	COG0183	Belongs to the thiolase family
FAM21731_RS05890	COG1301	dicarboxylic acid transport
FAM21731_RS05895	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FAM21731_RS05900	COG2022	thiamine diphosphate biosynthetic process
FAM21731_RS05905	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
FAM21731_RS05915	COG0352	thiamine-phosphate diphosphorylase activity
FAM21731_RS05945	COG0438	transferase activity, transferring glycosyl groups
FAM21731_RS05950	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
FAM21731_RS05970	COG0110	maltose O-acetyltransferase activity
FAM21731_RS05975	COG2814	Major facilitator Superfamily
FAM21731_RS05980	COG1780	Probably involved in ribonucleotide reductase function
FAM21731_RS05990	COG1253	flavin adenine dinucleotide binding
FAM21731_RS06000	COG0679	Auxin Efflux Carrier
FAM21731_RS06005	COG0656	L-ascorbic acid biosynthetic process
FAM21731_RS06010	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
FAM21731_RS06020	COG1454	alcohol dehydrogenase
FAM21731_RS06020	COG1012	belongs to the aldehyde dehydrogenase family
FAM21731_RS06040	COG1418	mRNA catabolic process
FAM21731_RS06050	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
FAM21731_RS06055	COG2188	Transcriptional regulator
FAM21731_RS06065	COG2814	Major facilitator Superfamily
FAM21731_RS06085	COG0564	pseudouridine synthase activity
FAM21731_RS06090	COG0589	response to stress
FAM21731_RS06095	COG0095	Lipoate-protein ligase
FAM21731_RS06155	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
FAM21731_RS06180	COG0531	amino acid
FAM21731_RS06185	COG2814	Major facilitator Superfamily
FAM21731_RS06195	COG0791	NLP P60 protein
FAM21731_RS06195	COG1388	LysM domain
FAM21731_RS06195	COG3103	Sh3 type 3 domain protein
FAM21731_RS06205	COG4485	Bacterial membrane protein, YfhO
FAM21731_RS06210	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
FAM21731_RS06250	COG0246	Mannitol dehydrogenase
FAM21731_RS06255	COG1904	glucuronate isomerase
FAM21731_RS06270	COG1070	Carbohydrate kinase
FAM21731_RS06280	COG2017	converts alpha-aldose to the beta-anomer
FAM21731_RS06285	COG1609	Transcriptional regulator
FAM21731_RS06295	COG2160	L-arabinose isomerase activity
FAM21731_RS06300	COG0110	maltose O-acetyltransferase activity
FAM21731_RS06305	COG0656	L-ascorbic acid biosynthetic process
FAM21731_RS06350	COG0488	(ABC) transporter
FAM21731_RS06365	COG2814	Major facilitator Superfamily
FAM21731_RS06370	COG1307	EDD domain protein, DegV family
FAM21731_RS06385	COG0708	Exodeoxyribonuclease III
FAM21731_RS06405	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FAM21731_RS06410	COG1609	Transcriptional regulator
FAM21731_RS06440	COG1028	Short-chain dehydrogenase reductase Sdr
FAM21731_RS06455	COG0095	Lipoate-protein ligase
FAM21731_RS06465	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
FAM21731_RS06475	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
FAM21731_RS06485	COG3639	organic phosphonate transmembrane transporter activity
FAM21731_RS06490	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FAM21731_RS06510	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FAM21731_RS06510	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
FAM21731_RS06525	COG2814	Major facilitator Superfamily
FAM21731_RS06535	COG1132	(ABC) transporter
FAM21731_RS06560	COG1073	alpha beta
FAM21731_RS06565	COG1278	Cold shock
FAM21731_RS06570	COG0542	response to heat
FAM21731_RS06580	COG2249	NAD(P)H dehydrogenase (quinone) activity
FAM21731_RS06590	COG0025	NhaP-type Na H and K H
FAM21731_RS06595	COG0351	phosphomethylpyrimidine kinase
FAM21731_RS06600	COG0569	domain protein
FAM21731_RS06605	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FAM21731_RS06610	COG0402	S-adenosylhomocysteine deaminase activity
FAM21731_RS06615	COG1442	glycosyl transferase family 8
FAM21731_RS06620	COG1132	(ABC) transporter
FAM21731_RS06630	COG1442	glycosyl transferase family 8
FAM21731_RS06645	COG0328	RNA-DNA hybrid ribonuclease activity
FAM21731_RS06650	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
FAM21731_RS06660	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FAM21731_RS06665	COG3189	MarR family transcriptional regulator
FAM21731_RS06670	COG2094	Belongs to the DNA glycosylase MPG family
FAM21731_RS06675	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
FAM21731_RS06680	COG0024	Methionine aminopeptidase
FAM21731_RS06685	COG3590	peptidase
FAM21731_RS06690	COG2326	polyphosphate kinase activity
FAM21731_RS06700	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
FAM21731_RS06705	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
FAM21731_RS06710	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
FAM21731_RS06720	COG1063	alcohol dehydrogenase
FAM21731_RS06730	COG0589	response to stress
FAM21731_RS06755	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
FAM21731_RS06760	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
FAM21731_RS06770	COG0735	belongs to the Fur family
FAM21731_RS06780	COG2706	6-phosphogluconolactonase activity
FAM21731_RS06785	COG2409	Drug exporters of the RND superfamily
FAM21731_RS06785	COG1033	growth of symbiont in host cell
FAM21731_RS06795	COG0179	Fumarylacetoacetate (FAA) hydrolase
FAM21731_RS06800	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FAM21731_RS06800	COG1199	ATP-dependent helicase activity
FAM21731_RS06815	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
FAM21731_RS06820	COG0527	aspartate kinase activity
FAM21731_RS06830	COG2171	N-acyltransferase activity
FAM21731_RS06835	COG1473	amidohydrolase
FAM21731_RS06840	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FAM21731_RS06845	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
FAM21731_RS06850	COG0436	Aminotransferase
FAM21731_RS06855	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
FAM21731_RS06890	COG2814	Major facilitator Superfamily
FAM21731_RS06910	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
FAM21731_RS06915	COG3842	ATPase activity
FAM21731_RS06960	COG4172	Belongs to the ABC transporter superfamily
FAM21731_RS06970	COG0561	phosphatase activity
FAM21731_RS06975	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
FAM21731_RS06995	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
FAM21731_RS07020	COG2826	transposase and inactivated derivatives, IS30 family
FAM21731_RS07080	COG1002	Type II restriction enzyme, methylase subunits
FAM21731_RS07110	COG4166	transmembrane transport
FAM21731_RS07115	COG1363	Peptidase, m42
FAM21731_RS07120	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
FAM21731_RS07135	COG0583	DNA-binding transcription factor activity
FAM21731_RS07145	COG1028	Short-chain dehydrogenase reductase Sdr
FAM21731_RS07155	COG4221	oxidoreductase activity
FAM21731_RS07160	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
FAM21731_RS07165	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FAM21731_RS07170	COG2011	ABC-type metal ion transport system permease component
FAM21731_RS07195	COG0411	ABC transporter
FAM21731_RS07200	COG0410	ABC transporter
FAM21731_RS07205	COG0517	IMP dehydrogenase activity
FAM21731_RS07205	COG0516	GMP reductase activity
FAM21731_RS07215	COG1122	ATPase activity
FAM21731_RS07220	COG4720	Psort location CytoplasmicMembrane, score
FAM21731_RS07225	COG0402	S-adenosylhomocysteine deaminase activity
FAM21731_RS07280	COG0514	ATP-dependent DNA helicase (RecQ)
FAM21731_RS07300	COG2814	Major facilitator Superfamily
FAM21731_RS07305	COG0791	NLP P60 protein
FAM21731_RS07315	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
FAM21731_RS07320	COG1122	ATPase activity
FAM21731_RS07325	COG1122	ATPase activity
FAM21731_RS07345	COG0531	amino acid
FAM21731_RS07360	COG0446	pyridine nucleotide-disulphide oxidoreductase
FAM21731_RS07370	COG1881	PFAM PEBP family protein
FAM21731_RS07380	COG2153	protein acetylation
FAM21731_RS07390	COG0456	acetyltransferase
FAM21731_RS07400	COG0517	IMP dehydrogenase activity
FAM21731_RS07405	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FAM21731_RS07405	COG0574	Belongs to the PEP-utilizing enzyme family
FAM21731_RS07410	COG1846	Transcriptional regulator
FAM21731_RS07425	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FAM21731_RS07430	COG1288	antiporter activity
FAM21731_RS07440	COG4120	Belongs to the binding-protein-dependent transport system permease family
FAM21731_RS07475	COG2755	lipolytic protein G-D-S-L family
FAM21731_RS07475	COG0657	acetylesterase activity
FAM21731_RS07480	COG1228	amidohydrolase
FAM21731_RS07495	COG1266	CAAX protease self-immunity
FAM21731_RS07505	COG0488	(ABC) transporter
FAM21731_RS07510	COG4166	transmembrane transport
FAM21731_RS07520	COG4948	Mandelate Racemase Muconate Lactonizing
FAM21731_RS07530	COG0366	Alpha amylase catalytic
FAM21731_RS07535	COG0366	Alpha amylase catalytic
FAM21731_RS07550	COG2267	carboxylic ester hydrolase activity
FAM21731_RS07555	COG2936	dipeptidyl-peptidase activity
FAM21731_RS07565	COG3250	beta-galactosidase activity
FAM21731_RS07595	COG0494	nUDIX hydrolase
FAM21731_RS07600	COG0194	GDP metabolic process
FAM21731_RS07605	COG0735	belongs to the Fur family
FAM21731_RS07620	COG0505	Belongs to the CarA family
FAM21731_RS07630	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FAM21731_RS07635	COG0765	amino acid transport
FAM21731_RS07640	COG0765	amino acid transport
FAM21731_RS07645	COG1285	pathogenesis
FAM21731_RS07650	COG0366	Alpha amylase catalytic
FAM21731_RS07660	COG1609	Transcriptional regulator
FAM21731_RS07665	COG0531	amino acid
FAM21731_RS07695	COG0601	transmembrane transport
FAM21731_RS07700	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FAM21731_RS07705	COG0444	Belongs to the ABC transporter superfamily
FAM21731_RS07710	COG4608	Belongs to the ABC transporter superfamily
FAM21731_RS07715	COG0789	Transcriptional regulator
FAM21731_RS07725	COG0588	phosphoglycerate mutase activity
FAM21731_RS07730	COG3973	AAA domain
FAM21731_RS07735	COG1072	(Pantothenic acid kinase))
FAM21731_RS07740	COG0519	Catalyzes the synthesis of GMP from XMP
FAM21731_RS07740	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FAM21731_RS07745	COG0546	phosphoglycolate phosphatase activity
FAM21731_RS07750	COG4975	Glucose uptake
FAM21731_RS07780	COG4975	Glucose uptake
FAM21731_RS07795	COG0308	aminopeptidase N
FAM21731_RS07810	COG1247	-acetyltransferase
FAM21731_RS07820	COG2217	Heavy metal translocating P-type atpase
FAM21731_RS07850	COG2814	Major facilitator Superfamily
FAM21731_RS07860	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FAM21731_RS07875	COG5002	protein histidine kinase activity
FAM21731_RS07880	COG0745	RESPONSE REGULATOR receiver
FAM21731_RS07895	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FAM21731_RS07905	COG1321	iron dependent repressor
FAM21731_RS07910	COG0477	Major facilitator Superfamily
FAM21731_RS07920	COG0446	pyridine nucleotide-disulphide oxidoreductase
FAM21731_RS07925	COG1473	amidohydrolase
FAM21731_RS07940	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
FAM21731_RS07945	COG2873	o-acetylhomoserine
FAM21731_RS07950	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
FAM21731_RS07955	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
FAM21731_RS07960	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
FAM21731_RS07965	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FAM21731_RS07970	COG0393	Putative heavy-metal-binding
FAM21731_RS07975	COG0446	pyridine nucleotide-disulphide oxidoreductase
FAM21731_RS07980	COG0564	pseudouridine synthase activity
FAM21731_RS08005	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
FAM21731_RS08015	COG1321	iron dependent repressor
FAM21731_RS08015	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FAM21731_RS08065	COG0833	amino acid
FAM21731_RS08070	COG3684	Belongs to the aldolase LacD family
FAM21731_RS08075	COG1428	Deoxynucleoside kinase
FAM21731_RS08080	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
FAM21731_RS08125	COG4463	regulation of RNA biosynthetic process
FAM21731_RS08130	COG0542	response to heat
FAM21731_RS08135	COG0085	RNA polymerase activity
FAM21731_RS08140	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
FAM21731_RS08145	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
FAM21731_RS08150	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
FAM21731_RS08155	COG0049	tRNA binding
FAM21731_RS08160	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FAM21731_RS08165	COG0051	transcription antitermination factor activity, RNA binding
FAM21731_RS08170	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
FAM21731_RS08175	COG0088	Forms part of the polypeptide exit tunnel
FAM21731_RS08180	COG0089	rRNA binding
FAM21731_RS08185	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
FAM21731_RS08195	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
FAM21731_RS08200	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
FAM21731_RS08205	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
FAM21731_RS08210	COG0255	Belongs to the universal ribosomal protein uL29 family
FAM21731_RS08220	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
FAM21731_RS08225	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
FAM21731_RS08230	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
FAM21731_RS08235	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
FAM21731_RS08240	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
FAM21731_RS08245	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
FAM21731_RS08250	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
FAM21731_RS08255	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
FAM21731_RS08265	COG0200	Binds to the 23S rRNA
FAM21731_RS08275	COG0563	adenylate kinase activity
FAM21731_RS08280	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
FAM21731_RS08285	COG0257	Belongs to the bacterial ribosomal protein bL36 family
FAM21731_RS08290	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
FAM21731_RS08295	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
FAM21731_RS08300	COG0202	RNA polymerase activity
FAM21731_RS08305	COG0203	ribosomal protein L17
FAM21731_RS08315	COG1122	ATPase activity
FAM21731_RS08320	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
FAM21731_RS08325	COG0101	tRNA pseudouridine synthase activity
FAM21731_RS08330	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
FAM21731_RS08335	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
FAM21731_RS08350	COG1705	Flagellar rod assembly protein muramidase FlgJ
FAM21731_RS08355	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FAM21731_RS08360	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
FAM21731_RS08370	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FAM21731_RS08375	COG4851	CamS sex pheromone cAM373 precursor
FAM21731_RS08380	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FAM21731_RS08385	COG0154	amidase activity
FAM21731_RS08390	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FAM21731_RS08395	COG1597	lipid kinase activity
FAM21731_RS08400	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FAM21731_RS08420	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
FAM21731_RS08425	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
FAM21731_RS08430	COG0813	purine-nucleoside phosphorylase activity
FAM21731_RS08435	COG2390	Transcriptional regulator
FAM21731_RS08440	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
FAM21731_RS08445	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FAM21731_RS08455	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FAM21731_RS08465	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
FAM21731_RS08470	COG1028	Short-chain dehydrogenase reductase Sdr
FAM21731_RS08475	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FAM21731_RS08480	COG0511	ligase activity, forming carbon-carbon bonds
FAM21731_RS08490	COG0439	Biotin carboxylase
FAM21731_RS08495	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
FAM21731_RS08500	COG0825	malonyl-CoA metabolic process
FAM21731_RS08505	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
FAM21731_RS08530	COG1070	Carbohydrate kinase
FAM21731_RS08535	COG1737	Transcriptional regulator
FAM21731_RS08550	COG0673	inositol 2-dehydrogenase activity
FAM21731_RS08555	COG0513	Belongs to the DEAD box helicase family
FAM21731_RS08565	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FAM21731_RS08570	COG0765	amino acid transport
FAM21731_RS08575	COG2246	polysaccharide biosynthetic process
FAM21731_RS08580	COG0463	Glycosyl transferase, family 2
FAM21731_RS08585	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
FAM21731_RS08590	COG1295	ribonuclease BN
FAM21731_RS08595	COG0716	FMN binding
FAM21731_RS08600	COG2137	regulation of response to DNA damage stimulus
FAM21731_RS08605	COG3557	Belongs to the UPF0374 family
FAM21731_RS08610	COG0628	permease
FAM21731_RS08615	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
FAM21731_RS08625	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
FAM21731_RS08650	COG0542	response to heat
FAM21731_RS08660	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FAM21731_RS08665	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FAM21731_RS08670	COG0438	transferase activity, transferring glycosyl groups
FAM21731_RS08675	COG0438	transferase activity, transferring glycosyl groups
FAM21731_RS08685	COG1368	sulfuric ester hydrolase activity
FAM21731_RS08745	COG1252	NADH dehydrogenase
FAM21731_RS08750	COG1271	oxidase subunit
FAM21731_RS08755	COG1294	oxidase, subunit
FAM21731_RS08760	COG4988	ABC transporter
FAM21731_RS08765	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
FAM21731_RS08775	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FAM21731_RS08780	COG3973	AAA domain
FAM21731_RS08795	COG0248	Ppx GppA phosphatase
FAM21731_RS08810	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
FAM21731_RS08815	COG1801	Protein of unknown function DUF72
FAM21731_RS08820	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FAM21731_RS08820	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FAM21731_RS08825	COG0084	hydrolase, TatD family'
FAM21731_RS08835	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FAM21731_RS08840	COG4466	Protein conserved in bacteria
FAM21731_RS08845	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
FAM21731_RS08850	COG1121	(ABC) transporter
FAM21731_RS08855	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FAM21731_RS08860	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FAM21731_RS08865	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
FAM21731_RS08870	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FAM21731_RS08880	COG0561	phosphatase activity
FAM21731_RS08885	COG1078	dGTPase activity
FAM21731_RS08890	COG0095	Lipoate-protein ligase
FAM21731_RS08900	COG3343	RNA polymerase activity
FAM21731_RS08905	COG0504	CTP synthase activity
FAM21731_RS08910	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FAM21731_RS08915	COG0254	rRNA binding
FAM21731_RS08925	COG3764	Sortase (surface protein transpeptidase)
FAM21731_RS08930	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FAM21731_RS08940	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
FAM21731_RS08955	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FAM21731_RS08965	COG2337	Toxic component of a toxin-antitoxin (TA) module
FAM21731_RS08975	COG0039	L-malate dehydrogenase activity
FAM21731_RS08980	COG0193	aminoacyl-tRNA hydrolase activity
FAM21731_RS08985	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
FAM21731_RS08990	COG2244	polysaccharide biosynthetic process
FAM21731_RS08995	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
FAM21731_RS09005	COG1098	S1 RNA binding domain
FAM21731_RS09010	COG0037	tRNA processing
FAM21731_RS09015	COG0037	tRNA processing
FAM21731_RS09015	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
FAM21731_RS09025	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
FAM21731_RS09030	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FAM21731_RS09035	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
FAM21731_RS09130	COG1061	Type III restriction enzyme res subunit
FAM21731_RS09325	COG3104	oligopeptide transport
FAM21731_RS09345	COG1250	3-hydroxyacyl-CoA dehydrogenase
FAM21731_RS09350	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
FAM21731_RS09355	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
FAM21731_RS09360	COG2188	Transcriptional regulator
FAM21731_RS09375	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
FAM21731_RS09395	COG0390	transport system, permease component
FAM21731_RS09400	COG4619	ABC transporter
FAM21731_RS09405	COG2183	response to ionizing radiation
FAM21731_RS09410	COG3091	SprT-like family
FAM21731_RS09415	COG0083	homoserine kinase activity
FAM21731_RS09425	COG0546	phosphoglycolate phosphatase activity
FAM21731_RS09430	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
FAM21731_RS09440	COG3715	PTS system
FAM21731_RS09445	COG3716	PTS system mannose fructose sorbose family IID component
FAM21731_RS09450	COG1316	TRANSCRIPTIONal
FAM21731_RS09460	COG0588	phosphoglycerate mutase activity
FAM21731_RS09470	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
FAM21731_RS09475	COG0756	dUTP diphosphatase activity
FAM21731_RS09480	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
FAM21731_RS09485	COG4956	integral membrane protein (PIN domain superfamily)
FAM21731_RS09490	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FAM21731_RS09495	COG0215	cysteine-tRNA ligase activity
FAM21731_RS09500	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
FAM21731_RS09505	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FAM21731_RS09520	COG0267	Belongs to the bacterial ribosomal protein bL33 family
FAM21731_RS09525	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FAM21731_RS09530	COG0250	Participates in transcription elongation, termination and antitermination
FAM21731_RS09540	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
FAM21731_RS09545	COG0081	regulation of translation
FAM21731_RS09550	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
FAM21731_RS09555	COG0222	ribosome binding
FAM21731_RS09560	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
FAM21731_RS09560	COG0392	lysyltransferase activity
FAM21731_RS09565	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
FAM21731_RS09570	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FAM21731_RS09575	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
FAM21731_RS09585	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FAM21731_RS09590	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FAM21731_RS09595	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
FAM21731_RS09600	COG2813	Specifically methylates the guanine in position
FAM21731_RS09615	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
FAM21731_RS09620	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
FAM21731_RS09635	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
FAM21731_RS09640	COG3870	Protein conserved in bacteria
FAM21731_RS09645	COG0470	DNA polymerase III
FAM21731_RS09655	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
FAM21731_RS09665	COG1214	PFAM Peptidase M22, glycoprotease
FAM21731_RS09670	COG0456	acetyltransferase
FAM21731_RS09675	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
FAM21731_RS09680	COG0488	(ABC) transporter
FAM21731_RS09685	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
FAM21731_RS09690	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
FAM21731_RS09695	COG0459	protein refolding
FAM21731_RS09700	COG0531	amino acid
FAM21731_RS09705	COG1346	cytolysis
FAM21731_RS09710	COG1380	Effector of murein hydrolase LrgA
FAM21731_RS09715	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FAM21731_RS09730	COG1739	Uncharacterized protein family UPF0029
FAM21731_RS09735	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
FAM21731_RS09750	COG0653	protein targeting
FAM21731_RS09760	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FAM21731_RS09765	COG0745	RESPONSE REGULATOR receiver
FAM21731_RS09770	COG5002	protein histidine kinase activity
FAM21731_RS09780	COG0573	inorganic phosphate transmembrane transporter activity
FAM21731_RS09785	COG0581	inorganic phosphate transmembrane transporter activity
FAM21731_RS09790	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
FAM21731_RS09795	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
FAM21731_RS09800	COG0704	Plays a role in the regulation of phosphate uptake
FAM21731_RS09805	COG1983	PspC domain protein
FAM21731_RS09810	COG1950	PFAM Membrane protein of
FAM21731_RS09815	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
FAM21731_RS09820	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
FAM21731_RS09825	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
FAM21731_RS09830	COG1210	Utp--glucose-1-phosphate uridylyltransferase
FAM21731_RS09835	COG0492	ferredoxin-NADP+ reductase activity
FAM21731_RS09845	COG0556	nucleotide-excision repair
FAM21731_RS09850	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FAM21731_RS09855	COG1660	Displays ATPase and GTPase activities
FAM21731_RS09865	COG1481	regulation of sporulation
FAM21731_RS09875	COG0740	serine-type endopeptidase activity
FAM21731_RS09880	COG0346	lactoylglutathione lyase activity
FAM21731_RS09885	COG0519	Catalyzes the synthesis of GMP from XMP
FAM21731_RS09905	COG0149	triose-phosphate isomerase activity
FAM21731_RS09910	COG0148	phosphopyruvate hydratase activity
FAM21731_RS09925	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FAM21731_RS09935	COG0557	exoribonuclease II activity
FAM21731_RS09940	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
FAM21731_RS09950	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
FAM21731_RS09955	COG0280	phosphate acetyltransferase
FAM21731_RS09960	COG0802	atpase or kinase
FAM21731_RS09970	COG2176	DNA-directed DNA polymerase activity
FAM21731_RS09975	COG0812	UDP-N-acetylmuramate dehydrogenase activity
FAM21731_RS09980	COG0025	NhaP-type Na H and K H
FAM21731_RS09985	COG2365	Tyrosine phosphatase family
FAM21731_RS09995	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
FAM21731_RS10010	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FAM21731_RS10015	COG1388	LysM domain
FAM21731_RS10015	COG1705	Flagellar rod assembly protein muramidase FlgJ
FAM21731_RS10020	COG1705	Flagellar rod assembly protein muramidase FlgJ
FAM21731_RS10020	COG3942	CHAP domain
FAM21731_RS10025	COG1134	teichoic acid transport
FAM21731_RS10055	COG3475	LICD family
FAM21731_RS10070	COG2261	transglycosylase associated protein
FAM21731_RS10085	COG1302	Protein conserved in bacteria
FAM21731_RS10105	COG1335	isochorismatase
FAM21731_RS10110	COG1113	amino acid transport
FAM21731_RS10135	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
FAM21731_RS10140	COG0477	Major facilitator Superfamily
FAM21731_RS10145	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
FAM21731_RS10150	COG0671	phosphoesterase, PA-phosphatase related
FAM21731_RS10155	COG0495	leucyl-tRNA aminoacylation
FAM21731_RS10175	COG2244	polysaccharide biosynthetic process
FAM21731_RS10180	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
FAM21731_RS10190	COG0589	response to stress
FAM21731_RS10205	COG1428	Deoxynucleoside kinase
FAM21731_RS10210	COG0561	phosphatase activity
FAM21731_RS10215	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FAM21731_RS10220	COG1554	hydrolase, family 65, central catalytic
FAM21731_RS10255	COG4166	transmembrane transport
FAM21731_RS10260	COG4948	Mandelate Racemase Muconate Lactonizing
FAM21731_RS10265	COG0791	NLP P60 protein
FAM21731_RS10275	COG1846	Transcriptional regulator
FAM21731_RS10390	COG3561	AntA/AntB antirepressor
FAM21731_RS10440	COG0305	Participates in initiation and elongation during chromosome replication
FAM21731_RS10520	COG2369	cell adhesion
FAM21731_RS10690	COG2826	transposase and inactivated derivatives, IS30 family
FAM21731_RS10700	COG0367	asparagine synthase
FAM21731_RS10730	COG0018	arginyl-trna synthetase
FAM21731_RS10735	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FAM21731_RS10745	COG0420	3'-5' exonuclease activity
FAM21731_RS10750	COG4717	serine-type aminopeptidase activity
FAM21731_RS10760	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FAM21731_RS10770	COG0537	adenosine 5'-monophosphoramidase activity
FAM21731_RS10775	COG1131	(ABC) transporter
FAM21731_RS10785	COG0220	tRNA (guanine-N7-)-methyltransferase activity
FAM21731_RS10795	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FAM21731_RS10800	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FAM21731_RS10805	COG1674	ftsk spoiiie
FAM21731_RS10810	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FAM21731_RS10815	COG0670	Belongs to the BI1 family
FAM21731_RS10825	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
FAM21731_RS10830	COG0237	dephospho-CoA kinase activity
FAM21731_RS10835	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
FAM21731_RS10845	COG1484	DNA-dependent DNA replication
FAM21731_RS10850	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
FAM21731_RS10855	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
FAM21731_RS10860	COG0291	Belongs to the bacterial ribosomal protein bL35 family
FAM21731_RS10865	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
FAM21731_RS10870	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
FAM21731_RS10875	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
FAM21731_RS10880	COG1534	Rna-binding protein
FAM21731_RS10885	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
FAM21731_RS10890	COG1713	HD superfamily hydrolase involved in NAD metabolism
FAM21731_RS10895	COG0799	negative regulation of ribosome biogenesis
FAM21731_RS10900	COG2226	methyltransferase
FAM21731_RS10905	COG1323	Belongs to the UPF0348 family
FAM21731_RS10920	COG1064	alcohol dehydrogenase
FAM21731_RS10925	COG0745	RESPONSE REGULATOR receiver
FAM21731_RS10930	COG5002	protein histidine kinase activity
FAM21731_RS10935	COG0569	domain protein
FAM21731_RS10935	COG0475	glutathione-regulated potassium exporter activity
FAM21731_RS10940	COG0706	membrane insertase activity
FAM21731_RS10950	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FAM21731_RS10960	COG1733	regulation of RNA biosynthetic process
FAM21731_RS10965	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
FAM21731_RS10970	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FAM21731_RS10970	COG0072	phenylalanine-tRNA ligase activity
FAM21731_RS10975	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
FAM21731_RS10980	COG0572	uridine kinase
FAM21731_RS10985	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FAM21731_RS10990	COG4841	protein insertion into membrane
FAM21731_RS11000	COG0768	penicillin binding
FAM21731_RS11005	COG0267	Belongs to the bacterial ribosomal protein bL33 family
FAM21731_RS11010	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
FAM21731_RS11015	COG0457	Tetratricopeptide repeat
FAM21731_RS11015	COG0705	Rhomboid family
FAM21731_RS11025	COG1940	carbohydrate kinase activity
FAM21731_RS11030	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FAM21731_RS11040	COG0584	glycerophosphoryl diester phosphodiesterase
FAM21731_RS11045	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
FAM21731_RS11050	COG0789	Transcriptional regulator
FAM21731_RS11060	COG4166	transmembrane transport
FAM21731_RS11100	COG0261	This protein binds to 23S rRNA in the presence of protein L20
FAM21731_RS11110	COG0211	Belongs to the bacterial ribosomal protein bL27 family
FAM21731_RS11115	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
FAM21731_RS11120	COG1302	Protein conserved in bacteria
FAM21731_RS11125	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FAM21731_RS11130	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
FAM21731_RS11135	COG1570	exodeoxyribonuclease VII activity
FAM21731_RS11140	COG1722	exodeoxyribonuclease VII activity
FAM21731_RS11150	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
FAM21731_RS11155	COG1438	arginine binding
FAM21731_RS11160	COG0497	DNA recombination
FAM21731_RS11170	COG0194	GDP metabolic process
FAM21731_RS11175	COG1758	RNA polymerase activity
FAM21731_RS11180	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
FAM21731_RS11185	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
FAM21731_RS11190	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
FAM21731_RS11195	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FAM21731_RS11195	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
FAM21731_RS11200	COG0631	protein serine/threonine phosphatase activity
FAM21731_RS11205	COG2815	serine threonine protein kinase
FAM21731_RS11205	COG0515	serine threonine protein kinase
FAM21731_RS11210	COG1162	GTPase activity
FAM21731_RS11215	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
FAM21731_RS11220	COG1564	THIamine pyrophosphokinase
FAM21731_RS11225	COG0227	Belongs to the bacterial ribosomal protein bL28 family
FAM21731_RS11230	COG1302	Protein conserved in bacteria
FAM21731_RS11235	COG1461	Dihydroxyacetone kinase
FAM21731_RS11240	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
FAM21731_RS11245	COG0416	fatty acid biosynthetic process
FAM21731_RS11250	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FAM21731_RS11255	COG0571	ribonuclease III activity
FAM21731_RS11260	COG1196	nuclear chromosome segregation
FAM21731_RS11265	COG0552	protein localization to endoplasmic reticulum
FAM21731_RS11270	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
FAM21731_RS11275	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
FAM21731_RS11280	COG0228	four-way junction DNA binding
FAM21731_RS11285	COG1837	Belongs to the UPF0109 family
FAM21731_RS11290	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
FAM21731_RS11295	COG0336	Belongs to the RNA methyltransferase TrmD family
FAM21731_RS11300	COG0335	large ribosomal subunit rRNA binding
FAM21731_RS11305	COG4974	Belongs to the 'phage' integrase family
FAM21731_RS11310	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
FAM21731_RS11315	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
FAM21731_RS11325	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
FAM21731_RS11330	COG0187	DNA topoisomerase II activity
FAM21731_RS11340	COG0583	DNA-binding transcription factor activity
FAM21731_RS11345	COG1227	inorganic diphosphatase activity
FAM21731_RS11350	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FAM21731_RS11360	COG1194	a g-specific adenine glycosylase
FAM21731_RS11365	COG4974	Belongs to the 'phage' integrase family
FAM21731_RS11370	COG3475	LICD family
FAM21731_RS11380	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
FAM21731_RS11385	COG0285	dihydrofolate synthase activity
FAM21731_RS11390	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
FAM21731_RS11390	COG0302	gtp cyclohydrolase
FAM21731_RS11400	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
FAM21731_RS11405	COG1307	EDD domain protein, DegV family
FAM21731_RS11415	COG1293	RNA-binding protein homologous to eukaryotic snRNP
FAM21731_RS11420	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
FAM21731_RS11425	COG0505	Belongs to the CarA family
FAM21731_RS11430	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
FAM21731_RS11435	COG0564	pseudouridine synthase activity
FAM21731_RS11440	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
FAM21731_RS11445	COG2759	Belongs to the formate--tetrahydrofolate ligase family
FAM21731_RS11455	COG0328	RNA-DNA hybrid ribonuclease activity
FAM21731_RS11460	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FAM21731_RS11465	COG0116	Belongs to the methyltransferase superfamily
FAM21731_RS11475	COG3599	regulation of cell shape
FAM21731_RS11480	COG4474	Belongs to the UPF0398 family
FAM21731_RS11485	COG3331	DNA recombination
FAM21731_RS11490	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FAM21731_RS11500	COG0017	Asparaginyl-tRNA synthetase
FAM21731_RS11505	COG0436	Aminotransferase
FAM21731_RS11515	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FAM21731_RS11515	COG1199	ATP-dependent helicase activity
FAM21731_RS11535	COG1304	FMN binding
FAM21731_RS11545	COG0561	phosphatase activity
FAM21731_RS11555	COG1942	4-Oxalocrotonate Tautomerase
FAM21731_RS11570	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FAM21731_RS11575	COG0758	DNA mediated transformation
FAM21731_RS11580	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
FAM21731_RS11585	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
FAM21731_RS11600	COG2755	lipolytic protein G-D-S-L family
FAM21731_RS11605	COG1307	EDD domain protein, DegV family
FAM21731_RS11610	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
FAM21731_RS11615	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
FAM21731_RS11620	COG0488	(ABC) transporter
FAM21731_RS11625	COG0617	tRNA 3'-terminal CCA addition
FAM21731_RS11630	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
FAM21731_RS11635	COG0457	Tetratricopeptide repeat
FAM21731_RS11645	COG1160	GTP binding
FAM21731_RS11650	COG0539	negative regulation of cytoplasmic translation
FAM21731_RS11655	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
FAM21731_RS11665	COG0514	ATP-dependent DNA helicase (RecQ)
FAM21731_RS11675	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
FAM21731_RS11680	COG1187	pseudouridine synthase activity
FAM21731_RS11685	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
FAM21731_RS11705	COG2996	Protein conserved in bacteria
FAM21731_RS11715	COG0587	DNA-directed DNA polymerase activity
FAM21731_RS11730	COG0542	response to heat
FAM21731_RS11740	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
FAM21731_RS11745	COG2384	SAM-dependent methyltransferase
FAM21731_RS11750	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FAM21731_RS11755	COG0358	DNA primase activity
FAM21731_RS11760	COG0751	glycine-tRNA ligase activity
FAM21731_RS11765	COG0752	glycyl-tRNA synthetase alpha subunit
FAM21731_RS11770	COG1381	Involved in DNA repair and RecF pathway recombination
FAM21731_RS11775	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
FAM21731_RS11780	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
FAM21731_RS11785	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
FAM21731_RS11790	COG1702	phosphate starvation-inducible protein PhoH
FAM21731_RS11795	COG1610	YqeY-like protein
FAM21731_RS11800	COG0828	Belongs to the bacterial ribosomal protein bS21 family
FAM21731_RS11805	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
FAM21731_RS11810	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
FAM21731_RS11815	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
FAM21731_RS11820	COG1682	transport, permease protein
FAM21731_RS11825	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
FAM21731_RS11830	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
FAM21731_RS11835	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
FAM21731_RS11840	COG0124	histidyl-tRNA synthetase
FAM21731_RS11845	COG3103	Sh3 type 3 domain protein
FAM21731_RS11845	COG0860	N-Acetylmuramoyl-L-alanine amidase
FAM21731_RS11845	COG4991	sh3 domain protein
FAM21731_RS11850	COG0546	phosphoglycolate phosphatase activity
FAM21731_RS11855	COG1490	D-aminoacyl-tRNA deacylase activity
FAM21731_RS11860	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FAM21731_RS11865	COG1385	rRNA (uridine-N3-)-methyltransferase activity
FAM21731_RS11870	COG2264	protein methyltransferase activity
FAM21731_RS11890	COG0481	GTPase activity
FAM21731_RS11895	COG0484	heat shock protein binding
FAM21731_RS11900	COG0443	Heat shock 70 kDa protein
FAM21731_RS11910	COG1420	regulation of RNA biosynthetic process
FAM21731_RS11915	COG0196	riboflavin kinase activity
FAM21731_RS11920	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
FAM21731_RS11925	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
FAM21731_RS11930	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
FAM21731_RS11935	COG1358	cellular component organization or biogenesis
FAM21731_RS11940	COG2740	Nucleic-acid-binding protein implicated in transcription termination
FAM21731_RS11945	COG0195	Participates in both transcription termination and antitermination
FAM21731_RS11950	COG0779	Required for maturation of 30S ribosomal subunits
FAM21731_RS11955	COG2176	DNA-directed DNA polymerase activity
FAM21731_RS11960	COG0442	prolyl-tRNA aminoacylation
FAM21731_RS11965	COG0750	zinc metalloprotease
FAM21731_RS11970	COG4589	Belongs to the CDS family
FAM21731_RS11975	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FAM21731_RS11985	COG0233	cytoplasmic translational termination
FAM21731_RS11990	COG0528	UMP kinase activity
FAM21731_RS12000	COG0052	Belongs to the universal ribosomal protein uS2 family
FAM21731_RS12010	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FAM21731_RS12015	COG2827	Endonuclease containing a URI domain
FAM21731_RS12020	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
FAM21731_RS12025	COG0204	Acyl-transferase
FAM21731_RS12030	COG3763	UPF0154 protein
FAM21731_RS12035	COG4224	UPF0291 protein
FAM21731_RS12040	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
FAM21731_RS12045	COG3425	synthase
FAM21731_RS12070	COG4470	Protein conserved in bacteria
FAM21731_RS12075	COG0737	Belongs to the 5'-nucleotidase family
FAM21731_RS12085	COG1113	amino acid transport
FAM21731_RS12095	COG0827	DNA restriction-modification system
FAM21731_RS12120	COG4537	Required for transformation and DNA binding
FAM21731_RS12130	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FAM21731_RS12135	COG0217	transcriptional regulatory protein
FAM21731_RS12140	COG1609	Transcriptional regulator
FAM21731_RS12145	COG0006	proline dipeptidase activity
FAM21731_RS12160	COG0668	transmembrane transport
FAM21731_RS12175	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
FAM21731_RS12180	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
FAM21731_RS12185	COG1719	4-vinyl reductase, 4VR
FAM21731_RS12190	COG3118	belongs to the thioredoxin family
FAM21731_RS12195	COG1193	negative regulation of DNA recombination
FAM21731_RS12200	COG1286	toxin biosynthetic process
FAM21731_RS12210	COG3906	Belongs to the UPF0473 family
FAM21731_RS12215	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
FAM21731_RS12220	COG4472	Bacterial protein of unknown function (DUF965)
FAM21731_RS12225	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FAM21731_RS12230	COG0513	Belongs to the DEAD box helicase family
FAM21731_RS12235	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
FAM21731_RS12240	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FAM21731_RS12250	COG0343	queuine tRNA-ribosyltransferase activity
FAM21731_RS12255	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
FAM21731_RS12260	COG2255	four-way junction helicase activity
FAM21731_RS12265	COG0632	four-way junction helicase activity
FAM21731_RS12270	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
FAM21731_RS12275	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
FAM21731_RS12280	COG1692	metallophosphoesterase
FAM21731_RS12285	COG1418	mRNA catabolic process
FAM21731_RS12290	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
FAM21731_RS12295	COG1546	Belongs to the CinA family
FAM21731_RS12295	COG1058	Belongs to the CinA family
FAM21731_RS12300	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
FAM21731_RS12305	COG1426	Protein conserved in bacteria
FAM21731_RS12310	COG0612	Peptidase, M16
FAM21731_RS12320	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FAM21731_RS12325	COG1126	abc transporter atp-binding protein
FAM21731_RS12330	COG0765	amino acid transport
FAM21731_RS12335	COG2894	cell division
FAM21731_RS12340	COG0850	regulation of cytokinetic process
FAM21731_RS12345	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
FAM21731_RS12350	COG1792	Involved in formation and maintenance of cell shape
FAM21731_RS12355	COG1077	Cell shape determining protein MreB Mrl
FAM21731_RS12360	COG0285	dihydrofolate synthase activity
FAM21731_RS12365	COG0525	valine-tRNA ligase activity
FAM21731_RS12375	COG0301	tRNA thio-modification
FAM21731_RS12380	COG1104	cysteine desulfurase activity
FAM21731_RS12385	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
FAM21731_RS12390	COG1956	GAF domain-containing protein
FAM21731_RS12440	COG2826	transposase and inactivated derivatives, IS30 family
FAM21731_RS12465	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FAM21731_RS12465	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FAM21731_RS12500	COG1914	H( )-stimulated, divalent metal cation uptake system
FAM21731_RS12505	COG0662	Cupin 2, conserved barrel domain protein
FAM21731_RS12550	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FAM21731_RS12660	COG3764	Sortase (surface protein transpeptidase)
FAM21731_RS12675	COG2207	Transcriptional regulator
FAM21731_RS12730	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FAM21731_RS12805	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FAM21731_RS12860	COG1192	Involved in chromosome partitioning
FAM21731_RS12895	COG2261	transglycosylase associated protein
FAM21731_RS12900	COG0028	Belongs to the TPP enzyme family
FAM21731_RS12910	COG1393	Belongs to the ArsC family
FAM21731_RS12915	COG2826	transposase and inactivated derivatives, IS30 family
FAM21731_RS12920	COG4975	Glucose uptake
FAM21731_RS12930	COG2261	transglycosylase associated protein
FAM21731_RS12940	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
FAM21731_RS12980	COG3328	transposase activity
FAM21731_RS12995	COG2801	Transposase and inactivated derivatives
FAM21731_RS13050	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
FAM21731_RS13060	COG0732	type I restriction modification DNA specificity domain
FAM21731_RS13070	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FAM21731_RS13205	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
FAM21731_RS13280	COG2801	Transposase and inactivated derivatives
FAM21731_RS13420	COG1228	amidohydrolase