locus-tag	class	description
APT55_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
APT55_RS00015	COG2361	Protein of unknown function DUF86
APT55_RS00025	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
APT55_RS00030	COG0745	RESPONSE REGULATOR receiver
APT55_RS00035	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
APT55_RS00065	COG1215	transferase activity, transferring glycosyl groups
APT55_RS00070	COG1215	transferase activity, transferring glycosyl groups
APT55_RS00075	COG1215	transferase activity, transferring glycosyl groups
APT55_RS00080	COG0745	RESPONSE REGULATOR receiver
APT55_RS00090	COG1803	Methylglyoxal synthase
APT55_RS00090	COG1597	lipid kinase activity
APT55_RS00095	COG4999	Histidine kinase
APT55_RS00095	COG3437	response regulator, receiver
APT55_RS00095	COG2205	protein histidine kinase activity
APT55_RS00095	COG3850	Histidine kinase
APT55_RS00100	COG3706	GGDEF domain
APT55_RS00100	COG2203	Gaf domain
APT55_RS00100	COG4251	negative regulation of phosphorylation
APT55_RS00100	COG5001	Diguanylate cyclase
APT55_RS00130	COG0315	cyclic pyranopterin monophosphate synthase activity
APT55_RS00140	COG0483	inositol monophosphate 1-phosphatase activity
APT55_RS00150	COG1028	Short-chain dehydrogenase reductase Sdr
APT55_RS00155	COG0589	response to stress
APT55_RS00160	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
APT55_RS00165	COG0268	Binds directly to 16S ribosomal RNA
APT55_RS00170	COG0084	hydrolase, TatD family'
APT55_RS00175	COG0085	RNA polymerase activity
APT55_RS00180	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
APT55_RS00185	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
APT55_RS00195	COG0724	RNA recognition motif
APT55_RS00200	COG0724	RNA recognition motif
APT55_RS00205	COG0828	Belongs to the bacterial ribosomal protein bS21 family
APT55_RS00215	COG0346	lactoylglutathione lyase activity
APT55_RS00220	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
APT55_RS00220	COG0140	phosphoribosyl-ATP diphosphatase activity
APT55_RS00225	COG1940	carbohydrate kinase activity
APT55_RS00260	COG0747	negative chemotaxis
APT55_RS00265	COG1131	(ABC) transporter
APT55_RS00285	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
APT55_RS00290	COG0519	Catalyzes the synthesis of GMP from XMP
APT55_RS00290	COG0518	GMP synthase (glutamine-hydrolyzing) activity
APT55_RS00295	COG2988	succinylglutamate desuccinylase activity
APT55_RS00310	COG2814	Major facilitator Superfamily
APT55_RS00330	COG3185	4-Hydroxyphenylpyruvate dioxygenase
APT55_RS00365	COG0205	6-phosphofructokinase activity
APT55_RS00370	COG0751	glycine-tRNA ligase activity
APT55_RS00375	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
APT55_RS00385	COG0469	pyruvate kinase activity
APT55_RS00390	COG5002	protein histidine kinase activity
APT55_RS00410	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
APT55_RS00410	COG0189	ligase activity
APT55_RS00420	COG4242	Belongs to the peptidase S51 family
APT55_RS00440	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
APT55_RS00485	COG1305	Transglutaminase-like
APT55_RS00515	COG1376	ErfK ybiS ycfS ynhG family protein
APT55_RS00525	COG0438	transferase activity, transferring glycosyl groups
APT55_RS00530	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
APT55_RS00540	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
APT55_RS00545	COG0812	UDP-N-acetylmuramate dehydrogenase activity
APT55_RS00550	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
APT55_RS00560	COG1357	PFAM Pentapeptide repeats (8 copies)
APT55_RS00560	COG0515	serine threonine protein kinase
APT55_RS00565	COG0424	maF-like protein
APT55_RS00750	COG0582	viral genome integration into host DNA
APT55_RS00770	COG2202	Pas domain
APT55_RS00770	COG2205	protein histidine kinase activity
APT55_RS00780	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
APT55_RS00795	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
APT55_RS00800	COG0318	PFAM AMP-dependent synthetase and ligase
APT55_RS00805	COG0181	hydroxymethylbilane synthase activity
APT55_RS00810	COG2022	thiamine diphosphate biosynthetic process
APT55_RS00810	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
APT55_RS00820	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
APT55_RS00835	COG0113	porphobilinogen synthase activity
APT55_RS00845	COG3852	Histidine kinase
APT55_RS00850	COG0300	oxidoreductase activity
APT55_RS00850	COG3000	fatty acid hydroxylase
APT55_RS00860	COG0561	phosphatase activity
APT55_RS00870	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
APT55_RS00875	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
APT55_RS00880	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
APT55_RS00885	COG3240	lipase activity
APT55_RS00915	COG4935	Belongs to the peptidase S8 family
APT55_RS00915	COG1404	Belongs to the peptidase S8 family
APT55_RS00930	COG0201	protein transport
APT55_RS00935	COG0563	adenylate kinase activity
APT55_RS00970	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
APT55_RS00975	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
APT55_RS00985	COG0230	Belongs to the bacterial ribosomal protein bL34 family
APT55_RS00990	COG0594	ribonuclease P activity
APT55_RS01000	COG0706	membrane insertase activity
APT55_RS01015	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
APT55_RS01030	COG2154	pterin-4-alpha-carbinolamine dehydratase
APT55_RS01045	COG2264	protein methyltransferase activity
APT55_RS01050	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
APT55_RS01060	COG0752	glycyl-tRNA synthetase alpha subunit
APT55_RS01100	COG0297	glycogen (starch) synthase activity
APT55_RS01105	COG1164	Oligoendopeptidase f
APT55_RS01135	COG0251	oxidation-reduction process
APT55_RS01145	COG1640	4-alpha-glucanotransferase
APT55_RS01155	COG0563	adenylate kinase activity
APT55_RS01185	COG0515	serine threonine protein kinase
APT55_RS01215	COG0646	methionine synthase
APT55_RS01215	COG1410	methionine synthase
APT55_RS01220	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
APT55_RS01225	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
APT55_RS01230	COG0457	Tetratricopeptide repeat
APT55_RS01230	COG0463	Glycosyl transferase, family 2
APT55_RS01245	COG0539	negative regulation of cytoplasmic translation
APT55_RS01250	COG0412	Dienelactone hydrolase
APT55_RS01255	COG1725	Transcriptional regulator
APT55_RS01270	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
APT55_RS01285	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
APT55_RS01295	COG1672	PFAM Archaeal ATPase
APT55_RS01295	COG2319	Wd-40 repeat
APT55_RS01300	COG0330	HflC and HflK could
APT55_RS01325	COG0784	Response regulator, receiver
APT55_RS01325	COG2205	protein histidine kinase activity
APT55_RS01325	COG5002	protein histidine kinase activity
APT55_RS01345	COG1028	Short-chain dehydrogenase reductase Sdr
APT55_RS01380	COG4941	Belongs to the sigma-70 factor family
APT55_RS01385	COG3795	YCII-related domain
APT55_RS01395	COG3795	YCII-related domain
APT55_RS01445	COG3751	2OG-Fe(II) oxygenase superfamily
APT55_RS01450	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
APT55_RS01455	COG0189	ligase activity
APT55_RS01480	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
APT55_RS01500	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
APT55_RS01505	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
APT55_RS01510	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
APT55_RS01520	COG1666	GTP binding
APT55_RS01565	COG0745	RESPONSE REGULATOR receiver
APT55_RS01570	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
APT55_RS01585	COG1595	DNA-templated transcription, initiation
APT55_RS01595	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
APT55_RS01625	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
APT55_RS01640	COG0784	Response regulator, receiver
APT55_RS01640	COG5002	protein histidine kinase activity
APT55_RS01660	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
APT55_RS01675	COG0438	transferase activity, transferring glycosyl groups
APT55_RS01680	COG1132	(ABC) transporter
APT55_RS01685	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
APT55_RS01690	COG0489	protein tyrosine kinase activity
APT55_RS01710	COG1372	Participates in initiation and elongation during chromosome replication
APT55_RS01710	COG0305	Participates in initiation and elongation during chromosome replication
APT55_RS01715	COG0359	binds to the 23S rRNA
APT55_RS01745	COG1122	ATPase activity
APT55_RS01750	COG0357	Ribosomal RNA small subunit methyltransferase G
APT55_RS01770	COG0110	maltose O-acetyltransferase activity
APT55_RS01785	COG0861	Integral membrane protein TerC family
APT55_RS01790	COG0791	NLP P60 protein
APT55_RS01805	COG1160	GTP binding
APT55_RS01810	COG0828	Belongs to the bacterial ribosomal protein bS21 family
APT55_RS01815	COG1672	PFAM Archaeal ATPase
APT55_RS01840	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
APT55_RS01855	COG0450	alkyl hydroperoxide reductase
APT55_RS01865	COG0484	heat shock protein binding
APT55_RS01870	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
APT55_RS01875	COG3631	Ketosteroid isomerase-related protein
APT55_RS01880	COG1959	2 iron, 2 sulfur cluster binding
APT55_RS01890	COG0784	Response regulator, receiver
APT55_RS01900	COG2205	protein histidine kinase activity
APT55_RS01900	COG0784	Response regulator, receiver
APT55_RS01900	COG5002	protein histidine kinase activity
APT55_RS01925	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
APT55_RS01935	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
APT55_RS01940	COG0052	Belongs to the universal ribosomal protein uS2 family
APT55_RS01950	COG1994	Peptidase M50
APT55_RS01950	COG0517	IMP dehydrogenase activity
APT55_RS01995	COG1598	PFAM Uncharacterised protein family UPF0150
APT55_RS02015	COG0463	Glycosyl transferase, family 2
APT55_RS02020	COG0484	heat shock protein binding
APT55_RS02025	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
APT55_RS02030	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
APT55_RS02035	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
APT55_RS02040	COG0529	Catalyzes the synthesis of activated sulfate
APT55_RS02085	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
APT55_RS02090	COG4251	negative regulation of phosphorylation
APT55_RS02090	COG3706	GGDEF domain
APT55_RS02090	COG2203	Gaf domain
APT55_RS02090	COG5001	Diguanylate cyclase
APT55_RS02095	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
APT55_RS02120	COG0516	GMP reductase activity
APT55_RS02135	COG0371	Dehydrogenase
APT55_RS02150	COG0436	Aminotransferase
APT55_RS02160	COG1902	pentaerythritol trinitrate reductase activity
APT55_RS02165	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
APT55_RS02190	COG2197	response regulator
APT55_RS02195	COG3411	Ferredoxin
APT55_RS02205	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
APT55_RS02235	COG3854	ATPases associated with a variety of cellular activities
APT55_RS02240	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
APT55_RS02265	COG3663	DNA glycosylase
APT55_RS02310	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
APT55_RS02315	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
APT55_RS02320	COG1131	(ABC) transporter
APT55_RS02380	COG0728	peptidoglycan biosynthetic process
APT55_RS02395	COG0366	Alpha amylase catalytic
APT55_RS02400	COG1733	regulation of RNA biosynthetic process
APT55_RS02410	COG0438	transferase activity, transferring glycosyl groups
APT55_RS02415	COG1554	hydrolase, family 65, central catalytic
APT55_RS02420	COG3239	Fatty acid desaturase
APT55_RS02425	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
APT55_RS02455	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
APT55_RS02470	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
APT55_RS02495	COG2010	Cytochrome c
APT55_RS02510	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
APT55_RS02515	COG0656	L-ascorbic acid biosynthetic process
APT55_RS02520	COG0517	IMP dehydrogenase activity
APT55_RS02520	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
APT55_RS02520	COG0617	tRNA 3'-terminal CCA addition
APT55_RS02530	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
APT55_RS02535	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
APT55_RS02555	COG2319	Wd-40 repeat
APT55_RS02555	COG4249	Peptidase C14 caspase catalytic subunit p20
APT55_RS02560	COG2911	Protein conserved in bacteria
APT55_RS02560	COG1361	Conserved repeat domain
APT55_RS02560	COG3266	domain, Protein
APT55_RS02565	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
APT55_RS02575	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
APT55_RS02580	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
APT55_RS02600	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
APT55_RS02615	COG2442	InterPro IPR007367
APT55_RS02620	COG0037	tRNA processing
APT55_RS02630	COG0784	Response regulator, receiver
APT55_RS02650	COG0840	transmembrane signaling receptor activity
APT55_RS02655	COG2198	Histidine kinase
APT55_RS02655	COG0784	Response regulator, receiver
APT55_RS02655	COG0643	Histidine kinase
APT55_RS02655	COG2198	Histidine kinase
APT55_RS02655	COG0784	Response regulator, receiver
APT55_RS02655	COG0643	Histidine kinase
APT55_RS02655	COG2198	Histidine kinase
APT55_RS02655	COG0784	Response regulator, receiver
APT55_RS02655	COG0643	Histidine kinase
APT55_RS02660	COG0438	transferase activity, transferring glycosyl groups
APT55_RS02670	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
APT55_RS02690	COG2814	Major facilitator Superfamily
APT55_RS02695	COG3659	wide pore channel activity
APT55_RS02720	COG4122	O-methyltransferase activity
APT55_RS02750	COG1132	(ABC) transporter
APT55_RS02765	COG4636	protein conserved in cyanobacteria
APT55_RS02775	COG2391	methyltransferase activity
APT55_RS02780	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
APT55_RS02785	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
APT55_RS02795	COG1846	Transcriptional regulator
APT55_RS02805	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
APT55_RS02825	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
APT55_RS02835	COG0489	protein tyrosine kinase activity
APT55_RS02850	COG3266	domain, Protein
APT55_RS02850	COG0515	serine threonine protein kinase
APT55_RS02865	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
APT55_RS02870	COG1116	anion transmembrane transporter activity
APT55_RS02880	COG0431	NADPH-dependent FMN reductase
APT55_RS02935	COG0671	phosphoesterase, PA-phosphatase related
APT55_RS02950	COG0730	response to heat
APT55_RS02965	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
APT55_RS02970	COG4208	sulfate ABC transporter
APT55_RS02975	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
APT55_RS02980	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
APT55_RS02995	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
APT55_RS03005	COG0811	peptide transport
APT55_RS03010	COG0848	biopolymer transport protein
APT55_RS03020	COG1285	pathogenesis
APT55_RS03025	COG3659	wide pore channel activity
APT55_RS03030	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
APT55_RS03045	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
APT55_RS03055	COG0583	DNA-binding transcription factor activity
APT55_RS03080	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
APT55_RS03090	COG2897	thiosulfate sulfurtransferase activity
APT55_RS03095	COG1028	Short-chain dehydrogenase reductase Sdr
APT55_RS03120	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
APT55_RS03135	COG1289	transmembrane transporter activity
APT55_RS03145	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
APT55_RS03155	COG2814	Major facilitator Superfamily
APT55_RS03160	COG0038	chloride channel
APT55_RS03225	COG0588	phosphoglycerate mutase activity
APT55_RS03230	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
APT55_RS03270	COG0784	Response regulator, receiver
APT55_RS03270	COG2198	Histidine kinase
APT55_RS03270	COG5002	protein histidine kinase activity
APT55_RS03300	COG2326	polyphosphate kinase activity
APT55_RS03315	COG0083	homoserine kinase activity
APT55_RS03320	COG0285	dihydrofolate synthase activity
APT55_RS03335	COG4948	Mandelate Racemase Muconate Lactonizing
APT55_RS03350	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
APT55_RS03360	COG0737	Belongs to the 5'-nucleotidase family
APT55_RS03365	COG0739	heme binding
APT55_RS03365	COG0741	lytic transglycosylase activity
APT55_RS03365	COG1196	nuclear chromosome segregation
APT55_RS03370	COG1496	oxidoreductase activity
APT55_RS03380	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
APT55_RS03385	COG2010	Cytochrome c
APT55_RS03390	COG2010	Cytochrome c
APT55_RS03400	COG2010	Cytochrome c
APT55_RS03410	COG2084	Dehydrogenase
APT55_RS03435	COG1216	Glycosyl transferase, family 2
APT55_RS03440	COG0137	argininosuccinate synthase activity
APT55_RS03465	COG1022	Amp-dependent synthetase and ligase
APT55_RS03470	COG1024	Enoyl-CoA hydratase
APT55_RS03470	COG1250	3-hydroxyacyl-CoA dehydrogenase
APT55_RS03475	COG0183	Belongs to the thiolase family
APT55_RS03480	COG1960	acyl-CoA dehydrogenase activity
APT55_RS03490	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
APT55_RS03495	COG0436	Aminotransferase
APT55_RS03500	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
APT55_RS03510	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
APT55_RS03515	COG3185	4-Hydroxyphenylpyruvate dioxygenase
APT55_RS03550	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
APT55_RS03555	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
APT55_RS03560	COG0640	Transcriptional regulator
APT55_RS03570	COG1446	asparaginase
APT55_RS03575	COG0596	Alpha beta hydrolase
APT55_RS03580	COG0784	Response regulator, receiver
APT55_RS03580	COG2205	protein histidine kinase activity
APT55_RS03620	COG0071	Belongs to the small heat shock protein (HSP20) family
APT55_RS03625	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
APT55_RS03635	COG0628	permease
APT55_RS03640	COG0076	glutamate decarboxylase activity
APT55_RS03650	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
APT55_RS03655	COG0508	dehydrogenase complex catalyzes the overall conversion of
APT55_RS03665	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
APT55_RS03690	COG0409	Hydrogenase expression formation protein
APT55_RS03695	COG0298	carbon dioxide binding
APT55_RS03700	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
APT55_RS03705	COG0375	protein maturation
APT55_RS03725	COG2871	sodium ion transport
APT55_RS03760	COG0025	NhaP-type Na H and K H
APT55_RS03765	COG1185	polyribonucleotide nucleotidyltransferase activity
APT55_RS03770	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
APT55_RS03775	COG4279	zinc finger
APT55_RS03785	COG0149	triose-phosphate isomerase activity
APT55_RS03800	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
APT55_RS03820	COG0237	dephospho-CoA kinase activity
APT55_RS03835	COG0402	S-adenosylhomocysteine deaminase activity
APT55_RS03840	COG2962	Rard protein
APT55_RS03845	COG0784	Response regulator, receiver
APT55_RS03845	COG2205	protein histidine kinase activity
APT55_RS03855	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
APT55_RS03865	COG0438	transferase activity, transferring glycosyl groups
APT55_RS03875	COG0438	transferase activity, transferring glycosyl groups
APT55_RS03880	COG1132	(ABC) transporter
APT55_RS03905	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
APT55_RS03920	COG0673	inositol 2-dehydrogenase activity
APT55_RS03930	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APT55_RS03945	COG0784	Response regulator, receiver
APT55_RS03960	COG2203	Gaf domain
APT55_RS03960	COG3706	GGDEF domain
APT55_RS03960	COG5001	Diguanylate cyclase
APT55_RS03960	COG4251	negative regulation of phosphorylation
APT55_RS03965	COG0643	Histidine kinase
APT55_RS03965	COG0784	Response regulator, receiver
APT55_RS03965	COG2198	Histidine kinase
APT55_RS03970	COG1012	belongs to the aldehyde dehydrogenase family
APT55_RS03990	COG1127	ABC transporter
APT55_RS04020	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
APT55_RS04025	COG0251	oxidation-reduction process
APT55_RS04030	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
APT55_RS04035	COG0025	NhaP-type Na H and K H
APT55_RS04055	COG1233	COG1233 Phytoene dehydrogenase and related
APT55_RS04065	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
APT55_RS04070	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
APT55_RS04075	COG0284	orotidine-5'-phosphate decarboxylase activity
APT55_RS04225	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
APT55_RS04230	COG0193	aminoacyl-tRNA hydrolase activity
APT55_RS04245	COG4372	Transposase
APT55_RS04250	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
APT55_RS04255	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
APT55_RS04265	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
APT55_RS04280	COG2897	thiosulfate sulfurtransferase activity
APT55_RS04290	COG2197	response regulator
APT55_RS04360	COG4249	Peptidase C14 caspase catalytic subunit p20
APT55_RS04360	COG2319	Wd-40 repeat
APT55_RS04390	COG1252	NADH dehydrogenase
APT55_RS04400	COG0492	ferredoxin-NADP+ reductase activity
APT55_RS04415	COG0586	Pfam SNARE associated Golgi protein
APT55_RS04425	COG1051	belongs to the nudix hydrolase family
APT55_RS04430	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
APT55_RS04440	COG0419	ATPase involved in DNA repair
APT55_RS04465	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
APT55_RS04475	COG0649	NAD binding
APT55_RS04485	COG0432	Pfam Uncharacterised protein family UPF0047
APT55_RS04505	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APT55_RS04510	COG0765	amino acid transport
APT55_RS04525	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
APT55_RS04530	COG1799	cell septum assembly
APT55_RS04540	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
APT55_RS04555	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
APT55_RS04565	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
APT55_RS04595	COG3852	Histidine kinase
APT55_RS04600	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
APT55_RS04605	COG0217	transcriptional regulatory protein
APT55_RS04610	COG0395	ABC-type sugar transport system, permease component
APT55_RS04645	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
APT55_RS04660	COG1216	Glycosyl transferase, family 2
APT55_RS04680	COG0438	transferase activity, transferring glycosyl groups
APT55_RS04695	COG1573	uracil-dna glycosylase
APT55_RS04705	COG2003	Belongs to the UPF0758 family
APT55_RS04710	COG2205	protein histidine kinase activity
APT55_RS04710	COG0784	Response regulator, receiver
APT55_RS04715	COG2226	methyltransferase
APT55_RS04720	COG0431	NADPH-dependent FMN reductase
APT55_RS04740	COG1846	Transcriptional regulator
APT55_RS04745	COG0450	alkyl hydroperoxide reductase
APT55_RS04755	COG2274	protein secretion by the type I secretion system
APT55_RS04765	COG0435	Glutathione S-transferase
APT55_RS04780	COG0596	Alpha beta hydrolase
APT55_RS04780	COG0508	dehydrogenase complex catalyzes the overall conversion of
APT55_RS04835	COG0460	homoserine dehydrogenase
APT55_RS04850	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
APT55_RS04855	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
APT55_RS04865	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
APT55_RS04870	COG0247	lactate metabolic process
APT55_RS04875	COG0277	FAD linked oxidase domain protein
APT55_RS04880	COG1366	Belongs to the anti-sigma-factor antagonist family
APT55_RS04880	COG2202	Pas domain
APT55_RS04885	COG3850	Histidine kinase
APT55_RS04885	COG5002	protein histidine kinase activity
APT55_RS04895	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
APT55_RS04910	COG3903	Transcriptional regulator
APT55_RS04910	COG2319	Wd-40 repeat
APT55_RS04940	COG0489	protein tyrosine kinase activity
APT55_RS04940	COG3206	protein involved in exopolysaccharide biosynthesis
APT55_RS04945	COG1032	radical SAM domain protein
APT55_RS04965	COG0497	DNA recombination
APT55_RS04970	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
APT55_RS04975	COG0488	(ABC) transporter
APT55_RS04985	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
APT55_RS04995	COG0824	Thioesterase
APT55_RS05000	COG0024	Methionine aminopeptidase
APT55_RS05010	COG0628	permease
APT55_RS05025	COG2319	Wd-40 repeat
APT55_RS05025	COG1672	PFAM Archaeal ATPase
APT55_RS05030	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
APT55_RS05040	COG0745	RESPONSE REGULATOR receiver
APT55_RS05045	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
APT55_RS05055	COG2204	response regulator
APT55_RS05070	COG1640	4-alpha-glucanotransferase
APT55_RS05075	COG0366	Alpha amylase catalytic
APT55_RS05090	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
APT55_RS05095	COG1160	GTP binding
APT55_RS05100	COG3268	Saccharopine dehydrogenase
APT55_RS05125	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
APT55_RS05140	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
APT55_RS05145	COG0602	queuosine metabolic process
APT55_RS05150	COG0720	synthase
APT55_RS05170	COG0454	-acetyltransferase
APT55_RS05180	COG0653	protein targeting
APT55_RS05185	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
APT55_RS05210	COG0039	L-malate dehydrogenase activity
APT55_RS05225	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
APT55_RS05230	COG0501	Belongs to the peptidase M48B family
APT55_RS05235	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
APT55_RS05250	COG4221	oxidoreductase activity
APT55_RS05260	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
APT55_RS05275	COG0408	coproporphyrinogen oxidase activity
APT55_RS05300	COG0667	Aldo Keto reductase
APT55_RS05310	COG1902	pentaerythritol trinitrate reductase activity
APT55_RS05320	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
APT55_RS05325	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
APT55_RS05340	COG0310	cobalt ion transport
APT55_RS05345	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
APT55_RS05355	COG1122	ATPase activity
APT55_RS05395	COG0009	L-threonylcarbamoyladenylate synthase
APT55_RS05400	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
APT55_RS05420	COG0745	RESPONSE REGULATOR receiver
APT55_RS05430	COG4251	negative regulation of phosphorylation
APT55_RS05440	COG1867	N(2),N(2)-dimethylguanosine tRNA methyltransferase
APT55_RS05465	COG0515	serine threonine protein kinase
APT55_RS05465	COG1262	PFAM Formylglycine-generating sulfatase enzyme
APT55_RS05490	COG0613	PHP domain protein
APT55_RS05495	COG2264	protein methyltransferase activity
APT55_RS05500	COG2133	pyrroloquinoline quinone binding
APT55_RS05535	COG0716	FMN binding
APT55_RS05540	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
APT55_RS05575	COG2226	methyltransferase
APT55_RS05590	COG1218	3'(2'),5'-bisphosphate nucleotidase
APT55_RS05600	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
APT55_RS05605	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
APT55_RS05615	COG0697	spore germination
APT55_RS05625	COG1598	PFAM Uncharacterised protein family UPF0150
APT55_RS05645	COG0318	PFAM AMP-dependent synthetase and ligase
APT55_RS05685	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
APT55_RS05715	COG4451	ribulose bisphosphate carboxylase, small
APT55_RS05715	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
APT55_RS05720	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
APT55_RS05725	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
APT55_RS05730	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
APT55_RS05735	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
APT55_RS05740	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
APT55_RS05755	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
APT55_RS05760	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
APT55_RS05770	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
APT55_RS05775	COG0583	DNA-binding transcription factor activity
APT55_RS05780	COG1035	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus
APT55_RS05825	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
APT55_RS05840	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
APT55_RS05845	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
APT55_RS05850	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
APT55_RS05855	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
APT55_RS05860	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
APT55_RS05865	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
APT55_RS05870	COG0109	protoheme IX farnesyltransferase activity
APT55_RS05880	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
APT55_RS05890	COG1845	cytochrome c oxidase, subunit III
APT55_RS05905	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
APT55_RS05910	COG0745	RESPONSE REGULATOR receiver
APT55_RS06045	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
APT55_RS06235	COG0739	heme binding
APT55_RS06235	COG0741	lytic transglycosylase activity
APT55_RS06235	COG1196	nuclear chromosome segregation
APT55_RS06375	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
APT55_RS06495	COG0539	negative regulation of cytoplasmic translation
APT55_RS06500	COG0546	phosphoglycolate phosphatase activity
APT55_RS06505	COG0745	RESPONSE REGULATOR receiver
APT55_RS06510	COG0739	heme binding
APT55_RS06515	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
APT55_RS06540	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
APT55_RS06555	COG3631	Ketosteroid isomerase-related protein
APT55_RS06575	COG4968	Prepilin-type N-terminal cleavage methylation domain
APT55_RS06580	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
APT55_RS06600	COG0484	heat shock protein binding
APT55_RS06605	COG0443	Heat shock 70 kDa protein
APT55_RS06610	COG1376	ErfK ybiS ycfS ynhG family protein
APT55_RS06625	COG2205	protein histidine kinase activity
APT55_RS06635	COG3239	Fatty acid desaturase
APT55_RS06660	COG0589	response to stress
APT55_RS06680	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
APT55_RS06690	COG0019	diaminopimelate decarboxylase activity
APT55_RS06705	COG1175	transmembrane transport
APT55_RS06715	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
APT55_RS06720	COG1262	PFAM Formylglycine-generating sulfatase enzyme
APT55_RS06725	COG0121	glutamine amidotransferase
APT55_RS06730	COG2363	Small membrane protein
APT55_RS06735	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
APT55_RS06740	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
APT55_RS06745	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
APT55_RS06750	COG1773	rubredoxin
APT55_RS06755	COG4447	cellulose binding
APT55_RS06810	COG0714	Associated with various cellular activities
APT55_RS06815	COG2205	protein histidine kinase activity
APT55_RS06820	COG1333	cytochrome c biogenesis protein
APT55_RS06825	COG4232	protein-disulfide reductase activity
APT55_RS06830	COG0772	Belongs to the SEDS family
APT55_RS06850	COG0420	3'-5' exonuclease activity
APT55_RS06855	COG0484	heat shock protein binding
APT55_RS06890	COG0735	belongs to the Fur family
APT55_RS06895	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
APT55_RS06900	COG0047	phosphoribosylformylglycinamidine synthase activity
APT55_RS06910	COG2223	nitrite transmembrane transporter activity
APT55_RS06925	COG2198	Histidine kinase
APT55_RS06925	COG2205	protein histidine kinase activity
APT55_RS06925	COG0784	Response regulator, receiver
APT55_RS06945	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
APT55_RS06950	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
APT55_RS06955	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
APT55_RS06960	COG2894	cell division
APT55_RS06965	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
APT55_RS07010	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
APT55_RS07040	COG0523	cobalamin synthesis protein
APT55_RS07045	COG0583	DNA-binding transcription factor activity
APT55_RS07050	COG2226	methyltransferase
APT55_RS07065	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
APT55_RS07070	COG1116	anion transmembrane transporter activity
APT55_RS07075	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
APT55_RS07080	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
APT55_RS07100	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
APT55_RS07110	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
APT55_RS07115	COG1132	(ABC) transporter
APT55_RS07120	COG1132	(ABC) transporter
APT55_RS07125	COG3850	Histidine kinase
APT55_RS07125	COG2205	protein histidine kinase activity
APT55_RS07125	COG3437	response regulator, receiver
APT55_RS07125	COG4999	Histidine kinase
APT55_RS07140	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
APT55_RS07145	COG4636	protein conserved in cyanobacteria
APT55_RS07155	COG1132	(ABC) transporter
APT55_RS07165	COG0438	transferase activity, transferring glycosyl groups
APT55_RS07165	COG0297	glycogen (starch) synthase activity
APT55_RS07170	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
APT55_RS07175	COG5002	protein histidine kinase activity
APT55_RS07180	COG0745	RESPONSE REGULATOR receiver
APT55_RS07185	COG0135	phosphoribosylanthranilate isomerase activity
APT55_RS07190	COG0302	gtp cyclohydrolase
APT55_RS07195	COG1028	Short-chain dehydrogenase reductase Sdr
APT55_RS07200	COG0825	malonyl-CoA metabolic process
APT55_RS07205	COG2226	methyltransferase
APT55_RS07220	COG1442	glycosyl transferase family 8
APT55_RS07220	COG1216	Glycosyl transferase, family 2
APT55_RS07225	COG5322	oxidoreductase activity
APT55_RS07230	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
APT55_RS07235	COG0395	ABC-type sugar transport system, permease component
APT55_RS07240	COG0803	Belongs to the bacterial solute-binding protein 9 family
APT55_RS07245	COG1121	(ABC) transporter
APT55_RS07250	COG1108	ABC-type Mn2 Zn2 transport systems permease components
APT55_RS07260	COG0523	cobalamin synthesis protein
APT55_RS07270	COG0113	porphobilinogen synthase activity
APT55_RS07300	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
APT55_RS07310	COG0523	cobalamin synthesis protein
APT55_RS07315	COG0302	gtp cyclohydrolase
APT55_RS07320	COG0523	cobalamin synthesis protein
APT55_RS07330	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
APT55_RS07330	COG4451	ribulose bisphosphate carboxylase, small
APT55_RS07335	COG0215	cysteine-tRNA ligase activity
APT55_RS07340	COG2226	methyltransferase
APT55_RS07350	COG0832	Belongs to the urease beta subunit family
APT55_RS07355	COG0831	urea catabolic process
APT55_RS07360	COG0829	nickel cation binding
APT55_RS07370	COG1216	Glycosyl transferase, family 2
APT55_RS07425	COG0724	RNA recognition motif
APT55_RS07435	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
APT55_RS07440	COG4251	negative regulation of phosphorylation
APT55_RS07450	COG2205	protein histidine kinase activity
APT55_RS07460	COG0434	BtpA family
APT55_RS07475	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
APT55_RS07485	COG0515	serine threonine protein kinase
APT55_RS07510	COG0439	Biotin carboxylase
APT55_RS07525	COG1074	ATP-dependent DNA helicase activity
APT55_RS07580	COG2202	Pas domain
APT55_RS07580	COG2205	protein histidine kinase activity
APT55_RS07590	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
APT55_RS07600	COG5002	protein histidine kinase activity
APT55_RS07615	COG0644	oxidoreductase
APT55_RS07620	COG1691	(AIR) carboxylase
APT55_RS07625	COG0747	negative chemotaxis
APT55_RS07635	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
APT55_RS07640	COG2202	Pas domain
APT55_RS07640	COG2205	protein histidine kinase activity
APT55_RS07655	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
APT55_RS07680	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
APT55_RS07695	COG0352	thiamine-phosphate diphosphorylase activity
APT55_RS07710	COG1049	propionate catabolic process, 2-methylcitrate cycle
APT55_RS07715	COG0415	Belongs to the DNA photolyase family
APT55_RS07725	COG1230	cation diffusion facilitator family transporter
APT55_RS07750	COG1473	amidohydrolase
APT55_RS07760	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
APT55_RS07775	COG0267	Belongs to the bacterial ribosomal protein bL33 family
APT55_RS07780	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
APT55_RS07785	COG0557	exoribonuclease II activity
APT55_RS07805	COG1230	cation diffusion facilitator family transporter
APT55_RS07810	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
APT55_RS07825	COG2304	oxidoreductase activity
APT55_RS07835	COG2124	cytochrome p450
APT55_RS07840	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
APT55_RS07845	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
APT55_RS07850	COG1649	PFAM Uncharacterised BCR, COG1649
APT55_RS07860	COG1011	Hydrolase
APT55_RS07865	COG1252	NADH dehydrogenase
APT55_RS07870	COG0802	atpase or kinase
APT55_RS07875	COG0391	Required for morphogenesis under gluconeogenic growth conditions
APT55_RS07880	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
APT55_RS07885	COG1268	BioY protein
APT55_RS07890	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
APT55_RS07905	COG0402	S-adenosylhomocysteine deaminase activity
APT55_RS07915	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
APT55_RS07925	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
APT55_RS07935	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APT55_RS07940	COG1136	(ABC) transporter
APT55_RS07940	COG0577	efflux transmembrane transporter activity
APT55_RS07950	COG0288	reversible hydration of carbon dioxide
APT55_RS07955	COG4191	Histidine kinase
APT55_RS07965	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
APT55_RS08000	COG4977	sequence-specific DNA binding
APT55_RS08000	COG1917	Cupin 2, conserved barrel domain protein
APT55_RS08010	COG2205	protein histidine kinase activity
APT55_RS08010	COG0784	Response regulator, receiver
APT55_RS08040	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
APT55_RS08050	COG0762	integral membrane protein
APT55_RS08055	COG0415	Belongs to the DNA photolyase family
APT55_RS08080	COG0439	Biotin carboxylase
APT55_RS08085	COG3665	Urea carboxylase-associated protein
APT55_RS08090	COG3665	Urea carboxylase-associated protein
APT55_RS08100	COG1116	anion transmembrane transporter activity
APT55_RS08105	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
APT55_RS08110	COG0174	glutamine synthetase
APT55_RS08115	COG2205	protein histidine kinase activity
APT55_RS08115	COG2198	Histidine kinase
APT55_RS08115	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APT55_RS08115	COG0784	Response regulator, receiver
APT55_RS08130	COG0336	Belongs to the RNA methyltransferase TrmD family
APT55_RS08135	COG4242	Belongs to the peptidase S51 family
APT55_RS08140	COG0189	ligase activity
APT55_RS08140	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
APT55_RS08150	COG0702	epimerase
APT55_RS08155	COG1028	Short-chain dehydrogenase reductase Sdr
APT55_RS08160	COG1937	Protein conserved in bacteria
APT55_RS08165	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
APT55_RS08175	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
APT55_RS08195	COG0154	amidase activity
APT55_RS08215	COG1316	TRANSCRIPTIONal
APT55_RS08220	COG0662	Cupin 2, conserved barrel domain protein
APT55_RS08220	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
APT55_RS08230	COG0505	Belongs to the CarA family
APT55_RS08245	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
APT55_RS08265	COG1981	membrane
APT55_RS08295	COG0601	transmembrane transport
APT55_RS08300	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
APT55_RS08305	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
APT55_RS08310	COG5002	protein histidine kinase activity
APT55_RS08310	COG0784	Response regulator, receiver
APT55_RS08310	COG2205	protein histidine kinase activity
APT55_RS08325	COG0071	Belongs to the small heat shock protein (HSP20) family
APT55_RS08330	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
APT55_RS08335	COG2385	sporulation resulting in formation of a cellular spore
APT55_RS08345	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
APT55_RS08350	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
APT55_RS08355	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
APT55_RS08355	COG1116	anion transmembrane transporter activity
APT55_RS08360	COG1116	anion transmembrane transporter activity
APT55_RS08375	COG0347	Belongs to the P(II) protein family
APT55_RS08380	COG0475	glutathione-regulated potassium exporter activity
APT55_RS08395	COG1834	amidinotransferase
APT55_RS08400	COG1473	amidohydrolase
APT55_RS08410	COG0732	type I restriction modification DNA specificity domain
APT55_RS08445	COG1054	Belongs to the UPF0176 family
APT55_RS08450	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
APT55_RS08455	COG0436	Aminotransferase
APT55_RS08465	COG2886	Uncharacterised protein family (UPF0175)
APT55_RS08480	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
APT55_RS08525	COG0156	8-amino-7-oxononanoate synthase activity
APT55_RS08560	COG0515	serine threonine protein kinase
APT55_RS08560	COG1357	PFAM Pentapeptide repeats (8 copies)
APT55_RS08565	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
APT55_RS08565	COG0072	phenylalanine-tRNA ligase activity
APT55_RS08590	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
APT55_RS08595	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
APT55_RS08600	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
APT55_RS08605	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
APT55_RS08610	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
APT55_RS08615	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
APT55_RS08620	COG0356	it plays a direct role in the translocation of protons across the membrane
APT55_RS08630	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
APT55_RS08645	COG1191	sigma factor activity
APT55_RS08670	COG0443	Heat shock 70 kDa protein
APT55_RS08675	COG0071	Belongs to the small heat shock protein (HSP20) family
APT55_RS08680	COG2027	D-alanyl-D-alanine carboxypeptidase
APT55_RS08690	COG1104	cysteine desulfurase activity
APT55_RS08715	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
APT55_RS08720	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
APT55_RS08725	COG0494	nUDIX hydrolase
APT55_RS08730	COG0415	Belongs to the DNA photolyase family
APT55_RS08760	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
APT55_RS08765	COG0488	(ABC) transporter
APT55_RS08785	COG0484	heat shock protein binding
APT55_RS08790	COG0740	serine-type endopeptidase activity
APT55_RS08795	COG0740	serine-type endopeptidase activity
APT55_RS08800	COG0740	serine-type endopeptidase activity
APT55_RS08805	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
APT55_RS08805	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
APT55_RS08820	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
APT55_RS08885	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
APT55_RS08905	COG4214	carbohydrate transport
APT55_RS08915	COG4213	ABC transporter substrate-binding protein
APT55_RS08920	COG3659	wide pore channel activity
APT55_RS08930	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
APT55_RS08930	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
APT55_RS08965	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
APT55_RS08970	COG0404	The glycine cleavage system catalyzes the degradation of glycine
APT55_RS08975	COG0740	serine-type endopeptidase activity
APT55_RS08985	COG1331	Highly conserved protein containing a thioredoxin domain
APT55_RS08990	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
APT55_RS09000	COG0412	Dienelactone hydrolase
APT55_RS09015	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
APT55_RS09045	COG5433	transposase activity
APT55_RS09050	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
APT55_RS09135	COG0402	S-adenosylhomocysteine deaminase activity
APT55_RS09145	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
APT55_RS09150	COG0257	Belongs to the bacterial ribosomal protein bL36 family
APT55_RS09155	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
APT55_RS09160	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
APT55_RS09165	COG0202	RNA polymerase activity
APT55_RS09170	COG0203	ribosomal protein L17
APT55_RS09175	COG0101	tRNA pseudouridine synthase activity
APT55_RS09180	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
APT55_RS09185	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
APT55_RS09190	COG0254	rRNA binding
APT55_RS09195	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
APT55_RS09235	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
APT55_RS09250	COG0475	glutathione-regulated potassium exporter activity
APT55_RS09250	COG0589	response to stress
APT55_RS09255	COG0745	RESPONSE REGULATOR receiver
APT55_RS09265	COG0322	excinuclease ABC activity
APT55_RS09280	COG0745	RESPONSE REGULATOR receiver
APT55_RS09285	COG0463	Glycosyl transferase, family 2
APT55_RS09300	COG3852	Histidine kinase
APT55_RS09325	COG0233	cytoplasmic translational termination
APT55_RS09330	COG0528	UMP kinase activity
APT55_RS09335	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
APT55_RS09340	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
APT55_RS09355	COG2723	6-phospho-beta-galactosidase activity
APT55_RS09365	COG1702	phosphate starvation-inducible protein PhoH
APT55_RS09370	COG0124	histidyl-tRNA synthetase
APT55_RS09380	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
APT55_RS09385	COG0776	regulation of translation
APT55_RS09400	COG0316	Belongs to the HesB IscA family
APT55_RS09420	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
APT55_RS09430	COG1053	succinate dehydrogenase
APT55_RS09435	COG5002	protein histidine kinase activity
APT55_RS09450	COG1555	photosystem II stabilization
APT55_RS09455	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
APT55_RS09475	COG1222	aaa ATPase
APT55_RS09540	COG0750	zinc metalloprotease
APT55_RS09545	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
APT55_RS09550	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
APT55_RS09560	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
APT55_RS09575	COG2177	Part of the ABC transporter FtsEX involved in
APT55_RS09625	COG0318	PFAM AMP-dependent synthetase and ligase
APT55_RS09630	COG2183	response to ionizing radiation
APT55_RS09655	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
APT55_RS09665	COG0572	uridine kinase
APT55_RS09670	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
APT55_RS09675	COG0457	Tetratricopeptide repeat
APT55_RS09685	COG0592	DNA-directed DNA polymerase activity
APT55_RS09700	COG1136	(ABC) transporter
APT55_RS09705	COG2226	methyltransferase
APT55_RS09710	COG0582	viral genome integration into host DNA
APT55_RS09715	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
APT55_RS09725	COG0758	DNA mediated transformation
APT55_RS09725	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
APT55_RS09770	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
APT55_RS09775	COG0003	Pfam Anion-transporting ATPase
APT55_RS09800	COG1450	Type ii and iii secretion system protein
APT55_RS09805	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
APT55_RS09820	COG1028	Short-chain dehydrogenase reductase Sdr
APT55_RS09825	COG3386	PFAM SMP-30 Gluconolaconase
APT55_RS09830	COG1295	ribonuclease BN
APT55_RS09840	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
APT55_RS09980	COG5002	protein histidine kinase activity
APT55_RS09990	COG5002	protein histidine kinase activity
APT55_RS10005	COG0784	Response regulator, receiver
APT55_RS10005	COG0835	chemotaxis
APT55_RS10015	COG0840	transmembrane signaling receptor activity
APT55_RS10025	COG0643	Histidine kinase
APT55_RS10025	COG2198	Histidine kinase
APT55_RS10025	COG0784	Response regulator, receiver
APT55_RS10030	COG2201	protein-glutamate methylesterase activity
APT55_RS10035	COG0745	RESPONSE REGULATOR receiver
APT55_RS10040	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
APT55_RS10060	COG2249	NAD(P)H dehydrogenase (quinone) activity
APT55_RS10065	COG3852	Histidine kinase
APT55_RS10070	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
APT55_RS10090	COG0672	)-iron permease
APT55_RS10095	COG3621	Patatin-like phospholipase
APT55_RS10110	COG0784	Response regulator, receiver
APT55_RS10110	COG5002	protein histidine kinase activity
APT55_RS10120	COG0589	response to stress
APT55_RS10125	COG0126	phosphoglycerate kinase activity
APT55_RS10130	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
APT55_RS10150	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
APT55_RS10160	COG0724	RNA recognition motif
APT55_RS10170	COG0573	inorganic phosphate transmembrane transporter activity
APT55_RS10175	COG0581	inorganic phosphate transmembrane transporter activity
APT55_RS10180	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
APT55_RS10185	COG0003	Pfam Anion-transporting ATPase
APT55_RS10190	COG0012	GTP binding
APT55_RS10200	COG1982	Orn Lys Arg decarboxylase major
APT55_RS10210	COG0575	Belongs to the CDS family
APT55_RS10260	COG0237	dephospho-CoA kinase activity
APT55_RS10260	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
APT55_RS10265	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
APT55_RS10270	COG0745	RESPONSE REGULATOR receiver
APT55_RS10275	COG2202	Pas domain
APT55_RS10275	COG2205	protein histidine kinase activity
APT55_RS10290	COG0745	RESPONSE REGULATOR receiver
APT55_RS10300	COG0643	Histidine kinase
APT55_RS10300	COG0784	Response regulator, receiver
APT55_RS10300	COG2198	Histidine kinase
APT55_RS10315	COG2201	protein-glutamate methylesterase activity
APT55_RS10325	COG2205	protein histidine kinase activity
APT55_RS10325	COG2202	Pas domain
APT55_RS10330	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
APT55_RS10345	COG1136	(ABC) transporter
APT55_RS10345	COG0577	efflux transmembrane transporter activity
APT55_RS10365	COG0017	Asparaginyl-tRNA synthetase
APT55_RS10380	COG3842	ATPase activity
APT55_RS10420	COG1845	cytochrome c oxidase, subunit III
APT55_RS10430	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
APT55_RS10445	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
APT55_RS10470	COG0033	Phosphoglucomutase
APT55_RS10475	COG0058	SHG alpha-glucan phosphorylase activity
APT55_RS10480	COG0406	alpha-ribazole phosphatase activity
APT55_RS10495	COG3659	wide pore channel activity
APT55_RS10505	COG3206	protein involved in exopolysaccharide biosynthesis
APT55_RS10505	COG0489	protein tyrosine kinase activity
APT55_RS10510	COG1361	Conserved repeat domain
APT55_RS10515	COG0159	tryptophan synthase activity
APT55_RS10540	COG1181	Belongs to the D-alanine--D-alanine ligase family
APT55_RS10550	COG2226	methyltransferase
APT55_RS10565	COG0837	glucose binding
APT55_RS10570	COG0259	pyridoxamine-phosphate oxidase activity
APT55_RS10580	COG1994	Peptidase M50
APT55_RS10580	COG0517	IMP dehydrogenase activity
APT55_RS10585	COG4953	penicillin-binding protein 1C
APT55_RS10590	COG2373	Large extracellular alpha-helical protein
APT55_RS10605	COG0438	transferase activity, transferring glycosyl groups
APT55_RS10625	COG0297	glycogen (starch) synthase activity
APT55_RS10645	COG0110	maltose O-acetyltransferase activity
APT55_RS10650	COG0297	glycogen (starch) synthase activity
APT55_RS10665	COG0297	glycogen (starch) synthase activity
APT55_RS10685	COG0438	transferase activity, transferring glycosyl groups
APT55_RS10690	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
APT55_RS10730	COG0445	tRNA wobble uridine modification
APT55_RS10735	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
APT55_RS10760	COG0328	RNA-DNA hybrid ribonuclease activity
APT55_RS10775	COG2208	phosphoserine phosphatase activity
APT55_RS10780	COG0552	protein localization to endoplasmic reticulum
APT55_RS10785	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
APT55_RS10800	COG0745	RESPONSE REGULATOR receiver
APT55_RS10810	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
APT55_RS10815	COG0271	Belongs to the BolA IbaG family
APT55_RS10830	COG3852	Histidine kinase
APT55_RS10865	COG1842	Phage shock protein A
APT55_RS10875	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
APT55_RS10880	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
APT55_RS10895	COG3240	lipase activity
APT55_RS10905	COG3250	beta-galactosidase activity
APT55_RS10915	COG0392	lysyltransferase activity
APT55_RS10915	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
APT55_RS10940	COG2081	HI0933 family
APT55_RS10995	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
APT55_RS11000	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
APT55_RS11005	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
APT55_RS11015	COG2197	response regulator
APT55_RS11025	COG2261	transglycosylase associated protein
APT55_RS11035	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
APT55_RS11060	COG1722	exodeoxyribonuclease VII activity
APT55_RS11065	COG1570	exodeoxyribonuclease VII activity
APT55_RS11070	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
APT55_RS11075	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
APT55_RS11080	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
APT55_RS11090	COG0784	Response regulator, receiver
APT55_RS11095	COG4251	negative regulation of phosphorylation
APT55_RS11100	COG0784	Response regulator, receiver
APT55_RS11110	COG3126	Type III secretion system lipoprotein chaperone (YscW)
APT55_RS11115	COG3386	PFAM SMP-30 Gluconolaconase
APT55_RS11140	COG1215	transferase activity, transferring glycosyl groups
APT55_RS11150	COG1216	Glycosyl transferase, family 2
APT55_RS11170	COG0681	Belongs to the peptidase S26 family
APT55_RS11180	COG1970	mechanosensitive ion channel activity
APT55_RS11185	COG0542	response to heat
APT55_RS11190	COG0456	acetyltransferase
APT55_RS11205	COG0456	acetyltransferase
APT55_RS11220	COG0019	diaminopimelate decarboxylase activity
APT55_RS11225	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
APT55_RS11230	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
APT55_RS11245	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
APT55_RS11250	COG1494	fructose-1,6-bisphosphatase
APT55_RS11265	COG0784	Response regulator, receiver
APT55_RS11265	COG5002	protein histidine kinase activity
APT55_RS11320	COG0612	Peptidase, M16
APT55_RS11325	COG3001	Fructosamine kinase
APT55_RS11335	COG0793	Belongs to the peptidase S41A family
APT55_RS11345	COG0625	glutathione transferase activity
APT55_RS11360	COG0343	queuine tRNA-ribosyltransferase activity
APT55_RS11365	COG1121	(ABC) transporter
APT55_RS11370	COG1108	ABC-type Mn2 Zn2 transport systems permease components
APT55_RS11385	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
APT55_RS11390	COG0404	The glycine cleavage system catalyzes the degradation of glycine
APT55_RS11395	COG0509	glycine decarboxylation via glycine cleavage system
APT55_RS11400	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
APT55_RS11400	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
APT55_RS11405	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
APT55_RS11410	COG0537	adenosine 5'-monophosphoramidase activity
APT55_RS11415	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
APT55_RS11420	COG0581	inorganic phosphate transmembrane transporter activity
APT55_RS11425	COG0573	inorganic phosphate transmembrane transporter activity
APT55_RS11430	COG3659	wide pore channel activity
APT55_RS11435	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
APT55_RS11445	COG0848	biopolymer transport protein
APT55_RS11450	COG0811	peptide transport
APT55_RS11490	COG0542	response to heat
APT55_RS11500	COG0724	RNA recognition motif
APT55_RS11505	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
APT55_RS11515	COG0644	oxidoreductase
APT55_RS11520	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
APT55_RS11530	COG1032	radical SAM domain protein
APT55_RS11595	COG5554	nitrogen fixation
APT55_RS11600	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
APT55_RS11605	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
APT55_RS11625	COG1104	cysteine desulfurase activity
APT55_RS11635	COG0535	radical SAM domain protein
APT55_RS11635	COG1433	Dinitrogenase iron-molybdenum cofactor
APT55_RS11640	COG1045	serine acetyltransferase
APT55_RS11650	COG0783	Belongs to the Dps family
APT55_RS11660	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
APT55_RS11665	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
APT55_RS11680	COG5420	small protein containing a coiled-coil domain
APT55_RS11725	COG4149	molybdate abc transporter
APT55_RS11730	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
APT55_RS11745	COG1733	regulation of RNA biosynthetic process
APT55_RS11760	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
APT55_RS11765	COG1012	belongs to the aldehyde dehydrogenase family
APT55_RS11765	COG1454	alcohol dehydrogenase
APT55_RS11770	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
APT55_RS11770	COG1042	CoA-binding domain protein
APT55_RS11770	COG0045	succinate-CoA ligase (ADP-forming) activity
APT55_RS11775	COG0731	radical SAM domain protein
APT55_RS11785	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
APT55_RS11810	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
APT55_RS11810	COG1672	PFAM Archaeal ATPase
APT55_RS11820	COG2255	four-way junction helicase activity
APT55_RS11850	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
APT55_RS11855	COG2066	Belongs to the glutaminase family
APT55_RS11860	COG2954	triphosphatase activity
APT55_RS11880	COG0747	negative chemotaxis
APT55_RS11900	COG0741	lytic transglycosylase activity
APT55_RS11900	COG0739	heme binding
APT55_RS11900	COG1196	nuclear chromosome segregation
APT55_RS11915	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
APT55_RS11925	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
APT55_RS11950	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
APT55_RS11955	COG1104	cysteine desulfurase activity
APT55_RS11980	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
APT55_RS11985	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
APT55_RS11995	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
APT55_RS12000	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
APT55_RS12000	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
APT55_RS12005	COG5002	protein histidine kinase activity
APT55_RS12010	COG0151	Belongs to the GarS family
APT55_RS12020	COG3903	Transcriptional regulator
APT55_RS12020	COG3629	intracellular signal transduction
APT55_RS12035	COG5002	protein histidine kinase activity
APT55_RS12040	COG0517	IMP dehydrogenase activity
APT55_RS12040	COG1125	glycine betaine transport
APT55_RS12045	COG1174	glycine betaine transport
APT55_RS12055	COG1505	serine-type exopeptidase activity
APT55_RS12065	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
APT55_RS12090	COG0723	plastoquinol--plastocyanin reductase activity
APT55_RS12100	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
APT55_RS12105	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
APT55_RS12110	COG1116	anion transmembrane transporter activity
APT55_RS12110	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
APT55_RS12115	COG1116	anion transmembrane transporter activity
APT55_RS12125	COG0243	molybdopterin cofactor binding
APT55_RS12130	COG2135	peptidase activity
APT55_RS12135	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
APT55_RS12150	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
APT55_RS12180	COG0438	transferase activity, transferring glycosyl groups
APT55_RS12185	COG0142	geranyltranstransferase activity
APT55_RS12190	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
APT55_RS12200	COG0105	UTP biosynthetic process
APT55_RS12205	COG1166	arginine decarboxylase activity
APT55_RS12230	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
APT55_RS12260	COG0745	RESPONSE REGULATOR receiver
APT55_RS12275	COG1492	cobalamin metabolic process
APT55_RS12290	COG0438	transferase activity, transferring glycosyl groups
APT55_RS12300	COG1381	Involved in DNA repair and RecF pathway recombination
APT55_RS12305	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
APT55_RS12315	COG2189	Belongs to the N(4) N(6)-methyltransferase family
APT55_RS12320	COG0644	oxidoreductase
APT55_RS12355	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
APT55_RS12375	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
APT55_RS12395	COG2308	Evidence 4 Homologs of previously reported genes of
APT55_RS12405	COG0811	peptide transport
APT55_RS12410	COG0848	biopolymer transport protein
APT55_RS12415	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
APT55_RS12420	COG1850	ribulose-bisphosphate carboxylase activity
APT55_RS12430	COG4451	ribulose bisphosphate carboxylase, small
APT55_RS12455	COG2204	response regulator
APT55_RS12460	COG2226	methyltransferase
APT55_RS12465	COG4399	Belongs to the UPF0754 family
APT55_RS12480	COG1162	GTPase activity
APT55_RS12490	COG0484	heat shock protein binding
APT55_RS12495	COG0443	Heat shock 70 kDa protein
APT55_RS12500	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
APT55_RS12505	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
APT55_RS12515	COG1459	type II secretion system
APT55_RS12540	COG0515	serine threonine protein kinase
APT55_RS12545	COG5002	protein histidine kinase activity
APT55_RS12555	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
APT55_RS12565	COG0006	proline dipeptidase activity
APT55_RS12580	COG0512	Glutamine amidotransferase of anthranilate synthase
APT55_RS12585	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
APT55_RS12590	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
APT55_RS12610	COG0492	ferredoxin-NADP+ reductase activity
APT55_RS12620	COG0714	Associated with various cellular activities
APT55_RS12650	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
APT55_RS12655	COG1006	Multisubunit Na H antiporter MnhC subunit
APT55_RS12660	COG0651	ATP synthesis coupled electron transport
APT55_RS12695	COG1215	transferase activity, transferring glycosyl groups
APT55_RS12700	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
APT55_RS12715	COG1233	COG1233 Phytoene dehydrogenase and related
APT55_RS12725	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
APT55_RS12740	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
APT55_RS12745	COG0438	transferase activity, transferring glycosyl groups
APT55_RS12750	COG0489	protein tyrosine kinase activity
APT55_RS12760	COG1215	transferase activity, transferring glycosyl groups
APT55_RS12775	COG1215	transferase activity, transferring glycosyl groups
APT55_RS12785	COG0438	transferase activity, transferring glycosyl groups
APT55_RS12795	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
APT55_RS12800	COG1490	D-aminoacyl-tRNA deacylase activity
APT55_RS12810	COG0523	cobalamin synthesis protein
APT55_RS12815	COG0215	cysteine-tRNA ligase activity
APT55_RS12825	COG0312	modulator of DNA gyrase
APT55_RS12830	COG1335	isochorismatase
APT55_RS12850	COG0569	domain protein
APT55_RS12855	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
APT55_RS12880	COG0850	regulation of cytokinetic process
APT55_RS12885	COG0438	transferase activity, transferring glycosyl groups
APT55_RS12895	COG0739	heme binding
APT55_RS12900	COG3852	Histidine kinase
APT55_RS12905	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
APT55_RS12920	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
APT55_RS12935	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
APT55_RS12940	COG2885	chlorophyll binding
APT55_RS12945	COG2885	chlorophyll binding
APT55_RS12960	COG1217	gtp-binding protein TYPA
APT55_RS12965	COG3659	wide pore channel activity
APT55_RS12970	COG1959	2 iron, 2 sulfur cluster binding
APT55_RS12975	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
APT55_RS12980	COG0514	ATP-dependent DNA helicase (RecQ)
APT55_RS12995	COG3878	Protein conserved in bacteria
APT55_RS13005	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
APT55_RS13025	COG0789	Transcriptional regulator
APT55_RS13035	COG2217	Heavy metal translocating P-type atpase
APT55_RS13045	COG0726	polysaccharide deacetylase
APT55_RS13055	COG0131	Imidazoleglycerol-phosphate dehydratase
APT55_RS13095	COG3659	wide pore channel activity
APT55_RS13105	COG2124	cytochrome p450
APT55_RS13115	COG0745	RESPONSE REGULATOR receiver
APT55_RS13120	COG5002	protein histidine kinase activity
APT55_RS13135	COG0435	Glutathione S-transferase
APT55_RS13180	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
APT55_RS13185	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
APT55_RS13200	COG1132	(ABC) transporter
APT55_RS13220	COG0745	RESPONSE REGULATOR receiver
APT55_RS13240	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
APT55_RS13245	COG0314	molybdopterin synthase activity
APT55_RS13250	COG1404	Belongs to the peptidase S8 family
APT55_RS13255	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
APT55_RS13260	COG0756	dUTP diphosphatase activity
APT55_RS13270	COG1132	(ABC) transporter
APT55_RS13275	COG0586	Pfam SNARE associated Golgi protein
APT55_RS13285	COG1215	transferase activity, transferring glycosyl groups
APT55_RS13290	COG0489	protein tyrosine kinase activity
APT55_RS13300	COG1045	serine acetyltransferase
APT55_RS13315	COG3307	-O-antigen
APT55_RS13325	COG2046	Belongs to the sulfate adenylyltransferase family
APT55_RS13355	COG0418	dihydroorotase activity
APT55_RS13370	COG0515	serine threonine protein kinase
APT55_RS13475	COG0745	RESPONSE REGULATOR receiver
APT55_RS13495	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
APT55_RS13505	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
APT55_RS13510	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
APT55_RS13515	COG0842	Transport permease protein
APT55_RS13520	COG0842	Transport permease protein
APT55_RS13525	COG1131	(ABC) transporter
APT55_RS13560	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
APT55_RS13585	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
APT55_RS13620	COG1555	photosystem II stabilization
APT55_RS13655	COG0583	DNA-binding transcription factor activity
APT55_RS13660	COG0129	dihydroxy-acid dehydratase activity
APT55_RS13820	COG1074	ATP-dependent DNA helicase activity
APT55_RS13845	COG0582	viral genome integration into host DNA
APT55_RS13850	COG0582	viral genome integration into host DNA
APT55_RS13860	COG0564	pseudouridine synthase activity
APT55_RS13865	COG0438	transferase activity, transferring glycosyl groups
APT55_RS13900	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
APT55_RS13925	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
APT55_RS13940	COG1403	HNH endonuclease
APT55_RS13945	COG1131	(ABC) transporter
APT55_RS13950	COG1234	tRNA 3'-trailer cleavage
APT55_RS13955	COG2385	sporulation resulting in formation of a cellular spore
APT55_RS13970	COG0785	Cytochrome C biogenesis protein
APT55_RS13975	COG5002	protein histidine kinase activity
APT55_RS13985	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
APT55_RS13990	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
APT55_RS13995	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
APT55_RS14005	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
APT55_RS14015	COG0792	nuclease activity
APT55_RS14025	COG4294	response to UV
APT55_RS14035	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
APT55_RS14040	COG0459	protein refolding
APT55_RS14045	COG0351	phosphomethylpyrimidine kinase
APT55_RS14060	COG5433	transposase activity
APT55_RS14080	COG0745	RESPONSE REGULATOR receiver
APT55_RS14085	COG5002	protein histidine kinase activity
APT55_RS14100	COG0517	IMP dehydrogenase activity
APT55_RS14100	COG1994	Peptidase M50
APT55_RS14115	COG1690	Belongs to the RtcB family
APT55_RS14120	COG0668	transmembrane transport
APT55_RS14130	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
APT55_RS14135	COG1408	metallophosphoesterase
APT55_RS14155	COG1028	Short-chain dehydrogenase reductase Sdr
APT55_RS14160	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
APT55_RS14165	COG2264	protein methyltransferase activity
APT55_RS14170	COG0531	amino acid
APT55_RS14180	COG5002	protein histidine kinase activity
APT55_RS14200	COG1017	nitric oxide dioxygenase activity
APT55_RS14200	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
APT55_RS14210	COG1950	PFAM Membrane protein of
APT55_RS14220	COG0628	permease
APT55_RS14225	COG0628	permease
APT55_RS14240	COG2239	Acts as a magnesium transporter
APT55_RS14260	COG5002	protein histidine kinase activity
APT55_RS14270	COG0745	RESPONSE REGULATOR receiver
APT55_RS14275	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
APT55_RS14290	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
APT55_RS14300	COG0730	response to heat
APT55_RS14335	COG3842	ATPase activity
APT55_RS14345	COG3659	wide pore channel activity
APT55_RS14355	COG1177	transmembrane transport
APT55_RS14380	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
APT55_RS14385	COG2205	protein histidine kinase activity
APT55_RS14385	COG4999	Histidine kinase
APT55_RS14385	COG3850	Histidine kinase
APT55_RS14385	COG3437	response regulator, receiver
APT55_RS14395	COG5002	protein histidine kinase activity
APT55_RS14400	COG3850	Histidine kinase
APT55_RS14400	COG2205	protein histidine kinase activity
APT55_RS14400	COG4999	Histidine kinase
APT55_RS14400	COG3437	response regulator, receiver
APT55_RS14420	COG0667	Aldo Keto reductase
APT55_RS14425	COG0180	Tryptophanyl-tRNA synthetase
APT55_RS14440	COG1262	PFAM Formylglycine-generating sulfatase enzyme
APT55_RS14445	COG1305	Transglutaminase-like
APT55_RS14455	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
APT55_RS14470	COG0228	four-way junction DNA binding
APT55_RS14475	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
APT55_RS14505	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
APT55_RS14505	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
APT55_RS14510	COG1429	ligase activity, forming nitrogen-metal bonds
APT55_RS14520	COG1653	transport
APT55_RS14535	COG3842	ATPase activity
APT55_RS14560	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
APT55_RS14705	COG1136	(ABC) transporter
APT55_RS14710	COG1136	(ABC) transporter
APT55_RS14710	COG0577	efflux transmembrane transporter activity
APT55_RS14735	COG0123	including yeast histone deacetylase and acetoin utilization protein
APT55_RS14775	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
APT55_RS14790	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
APT55_RS14795	COG1304	FMN binding
APT55_RS14800	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
APT55_RS14820	COG0333	Belongs to the bacterial ribosomal protein bL32 family
APT55_RS14825	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
APT55_RS14835	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
APT55_RS14845	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
APT55_RS14855	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
APT55_RS14865	COG0701	Predicted permease
APT55_RS14885	COG2217	Heavy metal translocating P-type atpase
APT55_RS14890	COG5001	Diguanylate cyclase
APT55_RS14890	COG1716	ATPase activity
APT55_RS14900	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
APT55_RS14905	COG3266	domain, Protein
APT55_RS14905	COG0515	serine threonine protein kinase
APT55_RS14910	COG0438	transferase activity, transferring glycosyl groups
APT55_RS14915	COG1619	proteins homologs of microcin C7 resistance protein MccF
APT55_RS14920	COG2319	Wd-40 repeat
APT55_RS14920	COG3903	Transcriptional regulator
APT55_RS14945	COG0204	Acyl-transferase
APT55_RS14950	COG2205	protein histidine kinase activity
APT55_RS14950	COG3437	response regulator, receiver
APT55_RS14950	COG3850	Histidine kinase
APT55_RS14950	COG4999	Histidine kinase
APT55_RS14965	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
APT55_RS15005	COG0438	transferase activity, transferring glycosyl groups
APT55_RS15045	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
APT55_RS15055	COG1830	Aldolase
APT55_RS15075	COG0297	glycogen (starch) synthase activity
APT55_RS15090	COG3842	ATPase activity
APT55_RS15095	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
APT55_RS15100	COG0601	transmembrane transport
APT55_RS15105	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
APT55_RS15125	COG0134	indole-3-glycerol-phosphate synthase activity
APT55_RS15130	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
APT55_RS15140	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
APT55_RS15145	COG1090	epimerase
APT55_RS15185	COG0157	Belongs to the NadC ModD family
APT55_RS15195	COG2233	PERMEase
APT55_RS15200	COG0018	arginyl-trna synthetase
APT55_RS15215	COG0242	peptide deformylase activity
APT55_RS15220	COG1132	(ABC) transporter
APT55_RS15230	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
APT55_RS15235	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
APT55_RS15245	COG0438	transferase activity, transferring glycosyl groups
APT55_RS15250	COG2144	transferase activity, transferring acyl groups
APT55_RS15275	COG2072	flavoprotein involved in K transport
APT55_RS15285	COG3237	CsbD-like
APT55_RS15290	COG0556	nucleotide-excision repair
APT55_RS15310	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
APT55_RS15325	COG3443	Belongs to the bacterial solute-binding protein 9 family
APT55_RS15325	COG0803	Belongs to the bacterial solute-binding protein 9 family
APT55_RS15330	COG1121	(ABC) transporter
APT55_RS15335	COG1108	ABC-type Mn2 Zn2 transport systems permease components
APT55_RS15340	COG1136	(ABC) transporter
APT55_RS15355	COG3659	wide pore channel activity
APT55_RS15380	COG3659	wide pore channel activity
APT55_RS15385	COG0346	lactoylglutathione lyase activity
APT55_RS15420	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
APT55_RS15445	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
APT55_RS15455	COG2211	Major facilitator Superfamily
APT55_RS15460	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
APT55_RS15495	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
APT55_RS15505	COG2205	protein histidine kinase activity
APT55_RS15505	COG3437	response regulator, receiver
APT55_RS15505	COG3850	Histidine kinase
APT55_RS15505	COG4999	Histidine kinase
APT55_RS15515	COG0481	GTPase activity
APT55_RS15520	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
APT55_RS15525	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
APT55_RS15555	COG0006	proline dipeptidase activity
APT55_RS15615	COG0475	glutathione-regulated potassium exporter activity
APT55_RS15625	COG0860	N-Acetylmuramoyl-L-alanine amidase
APT55_RS15625	COG2247	cell wall binding repeat
APT55_RS15645	COG1262	PFAM Formylglycine-generating sulfatase enzyme
APT55_RS15655	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
APT55_RS15665	COG2197	response regulator
APT55_RS15670	COG5002	protein histidine kinase activity
APT55_RS15700	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
APT55_RS15720	COG1160	GTP binding
APT55_RS15750	COG5002	protein histidine kinase activity
APT55_RS15755	COG1007	ATP synthesis coupled electron transport
APT55_RS15760	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
APT55_RS15775	COG3311	Transcriptional regulator
APT55_RS15780	COG1569	PIN domain
APT55_RS15815	COG3177	Filamentation induced by cAMP protein fic
APT55_RS15885	COG2189	Belongs to the N(4) N(6)-methyltransferase family
APT55_RS16000	COG0582	viral genome integration into host DNA
APT55_RS16010	COG0708	Exodeoxyribonuclease III
APT55_RS16015	COG3266	domain, Protein
APT55_RS16015	COG0515	serine threonine protein kinase
APT55_RS16020	COG0154	amidase activity
APT55_RS16035	COG5592	hemerythrin HHE cation binding domain
APT55_RS16045	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
APT55_RS16050	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
APT55_RS16050	COG1116	anion transmembrane transporter activity
APT55_RS16060	COG1116	anion transmembrane transporter activity
APT55_RS16085	COG0612	Peptidase, M16
APT55_RS16090	COG0577	efflux transmembrane transporter activity
APT55_RS16090	COG1136	(ABC) transporter
APT55_RS16110	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
APT55_RS16115	COG0456	acetyltransferase
APT55_RS16130	COG1132	(ABC) transporter
APT55_RS16135	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
APT55_RS16140	COG0745	RESPONSE REGULATOR receiver
APT55_RS16155	COG0672	)-iron permease
APT55_RS16160	COG1597	lipid kinase activity
APT55_RS16160	COG1803	Methylglyoxal synthase
APT55_RS16185	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
APT55_RS16190	COG1546	Belongs to the CinA family
APT55_RS16190	COG1058	Belongs to the CinA family
APT55_RS16195	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
APT55_RS16200	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
APT55_RS16210	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
APT55_RS16225	COG0028	Belongs to the TPP enzyme family
APT55_RS16285	COG0501	Belongs to the peptidase M48B family
APT55_RS16290	COG0705	Rhomboid family
APT55_RS16295	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
APT55_RS16300	COG2211	Major facilitator Superfamily
APT55_RS16305	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
APT55_RS16315	COG0616	signal peptide processing
APT55_RS16320	COG0697	spore germination
APT55_RS16365	COG0484	heat shock protein binding
APT55_RS16375	COG0438	transferase activity, transferring glycosyl groups
APT55_RS16385	COG0438	transferase activity, transferring glycosyl groups
APT55_RS16400	COG0745	RESPONSE REGULATOR receiver
APT55_RS16405	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
APT55_RS16415	COG0640	Transcriptional regulator
APT55_RS16425	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
APT55_RS16435	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
APT55_RS16460	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
APT55_RS16460	COG0475	glutathione-regulated potassium exporter activity
APT55_RS16465	COG2205	protein histidine kinase activity
APT55_RS16475	COG0312	modulator of DNA gyrase
APT55_RS16480	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
APT55_RS16485	COG5002	protein histidine kinase activity
APT55_RS16495	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
APT55_RS16515	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
APT55_RS16520	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
APT55_RS16530	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
APT55_RS16540	COG1366	Belongs to the anti-sigma-factor antagonist family
APT55_RS16545	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
APT55_RS16555	COG1530	ribonuclease E activity
APT55_RS16560	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
APT55_RS16570	COG1605	Chorismate mutase
APT55_RS16570	COG0077	Prephenate dehydratase
APT55_RS16580	COG0051	transcription antitermination factor activity, RNA binding
APT55_RS16595	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
APT55_RS16600	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
APT55_RS16605	COG0049	tRNA binding
APT55_RS16610	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
APT55_RS16615	COG0316	Belongs to the HesB IscA family
APT55_RS16625	COG5434	Belongs to the glycosyl hydrolase 28 family
APT55_RS16625	COG4632	Exopolysaccharide biosynthesis protein
APT55_RS16630	COG0069	glutamate synthase activity
APT55_RS16630	COG0070	glutamate synthase
APT55_RS16630	COG0067	glutamate synthase
APT55_RS16655	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
APT55_RS16660	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
APT55_RS16665	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
APT55_RS16670	COG0544	peptidyl-prolyl cis-trans isomerase activity
APT55_RS16675	COG0740	serine-type endopeptidase activity
APT55_RS16680	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
APT55_RS16690	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
APT55_RS16710	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
APT55_RS16730	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
APT55_RS16735	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
APT55_RS16735	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
APT55_RS16750	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
APT55_RS16755	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
APT55_RS16780	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
APT55_RS16785	COG1335	isochorismatase
APT55_RS16795	COG0704	Plays a role in the regulation of phosphate uptake
APT55_RS16800	COG1716	ATPase activity
APT55_RS16810	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
APT55_RS16835	COG1177	transmembrane transport
APT55_RS16840	COG1176	ABC-type spermidine putrescine transport system, permease component I
APT55_RS16845	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
APT55_RS16850	COG3842	ATPase activity
APT55_RS16870	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
APT55_RS16980	COG2203	Gaf domain
APT55_RS16980	COG0840	transmembrane signaling receptor activity
APT55_RS16985	COG0643	Histidine kinase
APT55_RS16985	COG2198	Histidine kinase
APT55_RS16985	COG0784	Response regulator, receiver
APT55_RS17015	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
APT55_RS17025	COG0390	transport system, permease component
APT55_RS17030	COG4251	negative regulation of phosphorylation
APT55_RS17035	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
APT55_RS17060	COG1012	belongs to the aldehyde dehydrogenase family
APT55_RS17070	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
APT55_RS17090	COG0163	prenyltransferase activity
APT55_RS17095	COG0557	exoribonuclease II activity
APT55_RS17100	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
APT55_RS17100	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
APT55_RS17120	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
APT55_RS17125	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
APT55_RS17130	COG5398	heme oxygenase
APT55_RS17135	COG0635	Involved in the biosynthesis of porphyrin-containing compound
APT55_RS17140	COG1361	Conserved repeat domain
APT55_RS17140	COG2911	Protein conserved in bacteria
APT55_RS17140	COG3266	domain, Protein
APT55_RS17185	COG0521	Mo-molybdopterin cofactor biosynthetic process
APT55_RS17190	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
APT55_RS17195	COG0745	RESPONSE REGULATOR receiver
APT55_RS17220	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
APT55_RS17225	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
APT55_RS17265	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
APT55_RS17275	COG2267	carboxylic ester hydrolase activity
APT55_RS17280	COG0564	pseudouridine synthase activity
APT55_RS17290	COG0657	acetylesterase activity
APT55_RS17350	COG0659	secondary active sulfate transmembrane transporter activity
APT55_RS17360	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
APT55_RS17375	COG0401	homolog of Blt101
APT55_RS17400	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APT55_RS17405	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
APT55_RS17410	COG0291	Belongs to the bacterial ribosomal protein bL35 family
APT55_RS17415	COG3659	wide pore channel activity
APT55_RS17420	COG0779	Required for maturation of 30S ribosomal subunits
APT55_RS17425	COG0195	Participates in both transcription termination and antitermination
APT55_RS17435	COG3266	domain, Protein
APT55_RS17435	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
APT55_RS17480	COG0222	ribosome binding
APT55_RS17485	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
APT55_RS17490	COG0081	regulation of translation
APT55_RS17495	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
APT55_RS17500	COG0250	Participates in transcription elongation, termination and antitermination
APT55_RS17505	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
APT55_RS17515	COG0335	large ribosomal subunit rRNA binding
APT55_RS17530	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
APT55_RS17535	COG1122	ATPase activity
APT55_RS17550	COG0386	Belongs to the glutathione peroxidase family
APT55_RS17560	COG0363	glucosamine-6-phosphate deaminase activity
APT55_RS17565	COG1131	(ABC) transporter
APT55_RS17590	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
APT55_RS17595	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
APT55_RS17605	COG0572	uridine kinase
APT55_RS17615	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
APT55_RS17630	COG2022	thiamine diphosphate biosynthetic process
APT55_RS17630	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
APT55_RS17635	COG2022	thiamine diphosphate biosynthetic process
APT55_RS17680	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
APT55_RS17685	COG0463	Glycosyl transferase, family 2
APT55_RS17690	COG0667	Aldo Keto reductase
APT55_RS17700	COG0857	belongs to the CobB CobQ family
APT55_RS17705	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
APT55_RS17745	COG0742	ribosomal rna small subunit methyltransferase
APT55_RS17750	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
APT55_RS17770	COG2972	Histidine kinase
APT55_RS17770	COG2205	protein histidine kinase activity
APT55_RS17790	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
APT55_RS17810	COG0277	FAD linked oxidase domain protein
APT55_RS17825	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
APT55_RS17850	COG1357	PFAM Pentapeptide repeats (8 copies)
APT55_RS17850	COG0515	serine threonine protein kinase
APT55_RS17855	COG1515	deoxyribonuclease V activity
APT55_RS17880	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
APT55_RS17885	COG0778	Nitroreductase
APT55_RS17895	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
APT55_RS17895	COG0574	Belongs to the PEP-utilizing enzyme family
APT55_RS17900	COG3546	catalase activity
APT55_RS17940	COG0187	DNA topoisomerase II activity
APT55_RS17940	COG1372	Participates in initiation and elongation during chromosome replication
APT55_RS17945	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
APT55_RS17970	COG2319	Wd-40 repeat
APT55_RS17970	COG4249	Peptidase C14 caspase catalytic subunit p20
APT55_RS17995	COG0367	asparagine synthase
APT55_RS18010	COG0625	glutathione transferase activity
APT55_RS18015	COG1136	(ABC) transporter
APT55_RS18075	COG4566	intracellular signal transduction
APT55_RS18080	COG1078	dGTPase activity
APT55_RS18085	COG0793	Belongs to the peptidase S41A family
APT55_RS18090	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
APT55_RS18095	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
APT55_RS18100	COG4636	protein conserved in cyanobacteria
APT55_RS18105	COG1079	Belongs to the binding-protein-dependent transport system permease family
APT55_RS18110	COG2226	methyltransferase
APT55_RS18140	COG0211	Belongs to the bacterial ribosomal protein bL27 family
APT55_RS18145	COG0261	This protein binds to 23S rRNA in the presence of protein L20
APT55_RS18155	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
APT55_RS18165	COG1357	PFAM Pentapeptide repeats (8 copies)
APT55_RS18165	COG0515	serine threonine protein kinase
APT55_RS18175	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
APT55_RS18180	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
APT55_RS18185	COG3659	wide pore channel activity
APT55_RS18195	COG1132	(ABC) transporter
APT55_RS18205	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
APT55_RS18210	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
APT55_RS18225	COG2239	Acts as a magnesium transporter
APT55_RS18230	COG0540	Belongs to the ATCase OTCase family
APT55_RS18235	COG1233	COG1233 Phytoene dehydrogenase and related
APT55_RS18255	COG0840	transmembrane signaling receptor activity
APT55_RS18255	COG2203	Gaf domain
APT55_RS18270	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
APT55_RS18285	COG0009	L-threonylcarbamoyladenylate synthase
APT55_RS18305	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
APT55_RS18315	COG0534	Mate efflux family protein
APT55_RS18320	COG0717	Belongs to the dCTP deaminase family
APT55_RS18330	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
APT55_RS18335	COG0598	Magnesium transport protein CorA
APT55_RS18360	COG0596	Alpha beta hydrolase
APT55_RS18370	COG0464	growth
APT55_RS18370	COG4451	ribulose bisphosphate carboxylase, small
APT55_RS18380	COG0107	imidazoleglycerol-phosphate synthase activity
APT55_RS18395	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
APT55_RS18410	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
APT55_RS18455	COG1733	regulation of RNA biosynthetic process
APT55_RS18475	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
APT55_RS18480	COG2202	Pas domain
APT55_RS18480	COG2199	diguanylate cyclase activity
APT55_RS18480	COG2200	EAL domain
APT55_RS18515	COG0628	permease
APT55_RS18520	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
APT55_RS18525	COG1047	Peptidyl-prolyl cis-trans
APT55_RS18535	COG1215	transferase activity, transferring glycosyl groups
APT55_RS18540	COG1178	ABC-type Fe3 transport system permease component
APT55_RS18545	COG3842	ATPase activity
APT55_RS18560	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
APT55_RS18565	COG0067	glutamate synthase
APT55_RS18565	COG0069	glutamate synthase activity
APT55_RS18565	COG0070	glutamate synthase
APT55_RS18570	COG0493	'glutamate synthase
APT55_RS18575	COG4771	TonB-dependent receptor
APT55_RS18580	COG0312	modulator of DNA gyrase
APT55_RS18585	COG0312	modulator of DNA gyrase
APT55_RS18590	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
APT55_RS18590	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
APT55_RS18625	COG0653	protein targeting
APT55_RS18645	COG1070	Carbohydrate kinase
APT55_RS18650	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
APT55_RS18660	COG1361	Conserved repeat domain
APT55_RS18665	COG1742	UPF0060 membrane protein
APT55_RS18680	COG1234	tRNA 3'-trailer cleavage
APT55_RS18685	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
APT55_RS18690	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
APT55_RS18700	COG0114	fumarate hydratase activity
APT55_RS18750	COG2274	protein secretion by the type I secretion system
APT55_RS18760	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
APT55_RS18770	COG1131	(ABC) transporter
APT55_RS18795	COG4172	Belongs to the ABC transporter superfamily
APT55_RS18800	COG0805	protein transport
APT55_RS18805	COG0515	serine threonine protein kinase
APT55_RS18805	COG3266	domain, Protein
APT55_RS18810	COG0604	alcohol dehydrogenase
APT55_RS18825	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
APT55_RS18830	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
APT55_RS18835	COG4208	sulfate ABC transporter
APT55_RS18840	COG1070	Carbohydrate kinase
APT55_RS18855	COG5002	protein histidine kinase activity
APT55_RS18860	COG0667	Aldo Keto reductase
APT55_RS18875	COG2197	response regulator
APT55_RS18880	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
APT55_RS18900	COG1253	flavin adenine dinucleotide binding
APT55_RS18905	COG0511	ligase activity, forming carbon-carbon bonds
APT55_RS18910	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
APT55_RS18915	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
APT55_RS18955	COG0138	bifunctional purine biosynthesis protein purh
APT55_RS18965	COG1543	Belongs to the glycosyl hydrolase 57 family
APT55_RS18975	COG0438	transferase activity, transferring glycosyl groups
APT55_RS18980	COG2205	protein histidine kinase activity
APT55_RS18980	COG0784	Response regulator, receiver
APT55_RS18990	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
APT55_RS19000	COG2197	response regulator
APT55_RS19020	COG0454	-acetyltransferase
APT55_RS19030	COG2197	response regulator
APT55_RS19050	COG2205	protein histidine kinase activity
APT55_RS19055	COG1361	Conserved repeat domain
APT55_RS19070	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
APT55_RS19075	COG0303	'Molybdopterin
APT55_RS19080	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
APT55_RS19110	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
APT55_RS19115	COG0811	peptide transport
APT55_RS19120	COG0848	biopolymer transport protein
APT55_RS19155	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
APT55_RS19165	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
APT55_RS19175	COG0587	DNA-directed DNA polymerase activity
APT55_RS19220	COG5001	Diguanylate cyclase
APT55_RS19220	COG4251	negative regulation of phosphorylation
APT55_RS19220	COG3706	GGDEF domain
APT55_RS19220	COG2203	Gaf domain
APT55_RS19225	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
APT55_RS19230	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
APT55_RS19250	COG1357	PFAM Pentapeptide repeats (8 copies)
APT55_RS19255	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
APT55_RS19260	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
APT55_RS19270	COG0612	Peptidase, M16
APT55_RS19275	COG0612	Peptidase, M16
APT55_RS19280	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
APT55_RS19300	COG2197	response regulator
APT55_RS19310	COG1136	(ABC) transporter
APT55_RS19310	COG0577	efflux transmembrane transporter activity
APT55_RS19335	COG1744	ABC transporter substrate-binding protein PnrA-like
APT55_RS19375	COG2095	MarC family integral membrane protein
APT55_RS19810	COG1695	Transcriptional regulator
APT55_RS19835	COG1783	phage Terminase large subunit
APT55_RS19890	COG0732	type I restriction modification DNA specificity domain
APT55_RS19895	COG2361	Protein of unknown function DUF86
APT55_RS19925	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
APT55_RS19945	COG0737	Belongs to the 5'-nucleotidase family
APT55_RS19950	COG0778	Nitroreductase
APT55_RS19955	COG0121	glutamine amidotransferase
APT55_RS19960	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
APT55_RS19985	COG3246	L-lysine catabolic process to acetate
APT55_RS20020	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
APT55_RS20030	COG0662	Cupin 2, conserved barrel domain protein
APT55_RS20030	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
APT55_RS20065	COG0023	Translation Initiation Factor
APT55_RS20075	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
APT55_RS20090	COG1253	flavin adenine dinucleotide binding
APT55_RS20095	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
APT55_RS20110	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
APT55_RS20120	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
APT55_RS20150	COG1077	Cell shape determining protein MreB Mrl
APT55_RS20155	COG0629	single-stranded DNA binding
APT55_RS20170	COG1595	DNA-templated transcription, initiation
APT55_RS20180	COG3852	Histidine kinase
APT55_RS20185	COG4221	oxidoreductase activity
APT55_RS20190	COG0045	succinate-CoA ligase (ADP-forming) activity
APT55_RS20200	COG0668	transmembrane transport
APT55_RS20205	COG3409	Peptidoglycan-binding domain 1 protein
APT55_RS20205	COG3429	Glucose-6-phosphate dehydrogenase subunit
APT55_RS20210	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
APT55_RS20215	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
APT55_RS20220	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
APT55_RS20225	COG0546	phosphoglycolate phosphatase activity
APT55_RS20235	COG2027	D-alanyl-D-alanine carboxypeptidase
APT55_RS20260	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
APT55_RS20280	COG1064	alcohol dehydrogenase
APT55_RS20290	COG1879	ABC-type sugar transport system periplasmic component
APT55_RS20295	COG1129	ABC transporter
APT55_RS20300	COG1172	Belongs to the binding-protein-dependent transport system permease family
APT55_RS20315	COG1252	NADH dehydrogenase
APT55_RS20325	COG1940	carbohydrate kinase activity
APT55_RS20335	COG2390	Transcriptional regulator
APT55_RS20345	COG1653	transport
APT55_RS20355	COG0395	ABC-type sugar transport system, permease component
APT55_RS20480	COG3264	Mechanosensitive ion channel
APT55_RS20480	COG1511	domain protein
APT55_RS20485	COG2202	Pas domain
APT55_RS20485	COG2205	protein histidine kinase activity
APT55_RS20505	COG0784	Response regulator, receiver
APT55_RS20505	COG5002	protein histidine kinase activity
APT55_RS20510	COG2197	response regulator
APT55_RS20525	COG0438	transferase activity, transferring glycosyl groups
APT55_RS20535	COG3659	wide pore channel activity
APT55_RS20560	COG0525	valine-tRNA ligase activity
APT55_RS20570	COG0572	uridine kinase
APT55_RS20575	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
APT55_RS20590	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
APT55_RS20605	COG0438	transferase activity, transferring glycosyl groups
APT55_RS20640	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
APT55_RS20645	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
APT55_RS20650	COG0416	fatty acid biosynthetic process
APT55_RS20665	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
APT55_RS20690	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
APT55_RS20700	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
APT55_RS20705	COG3937	granule-associated protein
APT55_RS20745	COG0156	8-amino-7-oxononanoate synthase activity
APT55_RS20810	COG1316	TRANSCRIPTIONal
APT55_RS20870	COG2226	methyltransferase
APT55_RS20885	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
APT55_RS20890	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
APT55_RS20905	COG3536	Protein conserved in bacteria
APT55_RS20910	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
APT55_RS20915	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
APT55_RS20930	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
APT55_RS20950	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
APT55_RS20955	COG0515	serine threonine protein kinase
APT55_RS20955	COG3266	domain, Protein
APT55_RS20965	COG3852	Histidine kinase
APT55_RS20980	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
APT55_RS20985	COG0322	excinuclease ABC activity
APT55_RS21000	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
APT55_RS21020	COG0702	epimerase
APT55_RS21040	COG0004	ammonium transporteR
APT55_RS21045	COG0004	ammonium transporteR
APT55_RS21050	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
APT55_RS21060	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
APT55_RS21065	COG0596	Alpha beta hydrolase
APT55_RS21075	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
APT55_RS21080	COG3659	wide pore channel activity
APT55_RS21095	COG1122	ATPase activity
APT55_RS21115	COG3688	RNA-binding protein containing a PIN domain
APT55_RS21120	COG0842	Transport permease protein
APT55_RS21120	COG1131	(ABC) transporter
APT55_RS21120	COG1716	ATPase activity
APT55_RS21130	COG3547	Transposase (IS116 IS110 IS902 family)
APT55_RS21145	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
APT55_RS21165	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
APT55_RS21185	COG2226	methyltransferase
APT55_RS21195	COG0360	Binds together with S18 to 16S ribosomal RNA
APT55_RS21215	COG3437	response regulator, receiver
APT55_RS21220	COG1408	metallophosphoesterase
APT55_RS21230	COG0398	Pfam SNARE associated Golgi protein
APT55_RS21235	COG5398	heme oxygenase
APT55_RS21250	COG2226	methyltransferase
APT55_RS21255	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
APT55_RS21285	COG0776	regulation of translation
APT55_RS21290	COG0783	Belongs to the Dps family
APT55_RS21310	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
APT55_RS21335	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
APT55_RS21340	COG0631	protein serine/threonine phosphatase activity
APT55_RS21345	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
APT55_RS21350	COG3937	granule-associated protein
APT55_RS21355	COG0515	serine threonine protein kinase
APT55_RS21355	COG1357	PFAM Pentapeptide repeats (8 copies)
APT55_RS21365	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
APT55_RS21375	COG0596	Alpha beta hydrolase
APT55_RS21385	COG0783	Belongs to the Dps family
APT55_RS21455	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
APT55_RS21460	COG1610	YqeY-like protein
APT55_RS21465	COG0542	response to heat
APT55_RS21470	COG1429	ligase activity, forming nitrogen-metal bonds
APT55_RS21480	COG0038	chloride channel
APT55_RS21490	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
APT55_RS21495	COG2738	Putative neutral zinc metallopeptidase
APT55_RS21505	COG0799	negative regulation of ribosome biogenesis
APT55_RS21525	COG0352	thiamine-phosphate diphosphorylase activity
APT55_RS21535	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
APT55_RS21545	COG2912	Transglutaminase-like superfamily
APT55_RS21555	COG0668	transmembrane transport
APT55_RS21560	COG2884	Cell division ATP-binding protein ftsE
APT55_RS21570	COG3179	chitinase
APT55_RS21575	COG1434	Gram-negative-bacterium-type cell wall biogenesis
APT55_RS21580	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
APT55_RS21590	COG0133	tryptophan synthase activity
APT55_RS21600	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
APT55_RS21600	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
APT55_RS21605	COG0768	penicillin binding
APT55_RS21610	COG0436	Aminotransferase
APT55_RS21620	COG1529	Aldehyde oxidase and xanthine dehydrogenase
APT55_RS21635	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
APT55_RS21680	COG1487	ribonuclease activity
APT55_RS21690	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
APT55_RS21695	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
APT55_RS21700	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
APT55_RS21705	COG0148	phosphopyruvate hydratase activity
APT55_RS21715	COG0024	Methionine aminopeptidase
APT55_RS21720	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
APT55_RS21730	COG0515	serine threonine protein kinase
APT55_RS21745	COG0632	four-way junction helicase activity
APT55_RS21750	COG0561	phosphatase activity
APT55_RS21765	COG0601	transmembrane transport
APT55_RS21770	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
APT55_RS21800	COG0196	riboflavin kinase activity
APT55_RS21805	COG1649	PFAM Uncharacterised BCR, COG1649
APT55_RS21815	COG2351	hydroxyisourate hydrolase activity
APT55_RS21830	COG0583	DNA-binding transcription factor activity
APT55_RS21840	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
APT55_RS21870	COG0515	serine threonine protein kinase
APT55_RS21870	COG2815	serine threonine protein kinase
APT55_RS21880	COG3118	belongs to the thioredoxin family
APT55_RS21890	COG3118	belongs to the thioredoxin family
APT55_RS21895	COG0436	Aminotransferase
APT55_RS21920	COG2205	protein histidine kinase activity
APT55_RS21925	COG0788	formyltetrahydrofolate deformylase activity
APT55_RS21960	COG0815	Transfers the fatty acyl group on membrane lipoproteins
APT55_RS21965	COG3781	membrane
APT55_RS21985	COG0628	permease
APT55_RS22015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
APT55_RS22020	COG0459	protein refolding
APT55_RS22025	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
APT55_RS22035	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
APT55_RS22055	COG0237	dephospho-CoA kinase activity
APT55_RS22060	COG3546	catalase activity
APT55_RS22075	COG0714	Associated with various cellular activities
APT55_RS22085	COG3552	Protein containing von Willebrand factor type A (VWA) domain
APT55_RS22090	COG4715	Zinc finger, swim domain protein
APT55_RS22095	COG0826	peptidase U32
APT55_RS22100	COG1285	pathogenesis
APT55_RS22125	COG2319	Wd-40 repeat
APT55_RS22125	COG4249	Peptidase C14 caspase catalytic subunit p20
APT55_RS22140	COG3659	wide pore channel activity
APT55_RS22145	COG1802	Transcriptional regulator
APT55_RS22150	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
APT55_RS22165	COG2119	membrane
APT55_RS22175	COG2261	transglycosylase associated protein
APT55_RS22185	COG0277	FAD linked oxidase domain protein
APT55_RS22215	COG0784	Response regulator, receiver
APT55_RS22215	COG2205	protein histidine kinase activity
APT55_RS22260	COG0616	signal peptide processing
APT55_RS22270	COG2226	methyltransferase
APT55_RS22275	COG0463	Glycosyl transferase, family 2
APT55_RS22280	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
APT55_RS22290	COG1797	cobyrinic acid a,c-diamide synthase activity
APT55_RS22330	COG0443	Heat shock 70 kDa protein
APT55_RS22340	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
APT55_RS22345	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
APT55_RS22350	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
APT55_RS22355	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
APT55_RS22360	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
APT55_RS22370	COG1028	Short-chain dehydrogenase reductase Sdr
APT55_RS22375	COG0420	3'-5' exonuclease activity
APT55_RS22390	COG0745	RESPONSE REGULATOR receiver
APT55_RS22400	COG5002	protein histidine kinase activity
APT55_RS22410	COG3659	wide pore channel activity
APT55_RS22415	COG0436	Aminotransferase
APT55_RS22435	COG0191	fructose-bisphosphate aldolase activity
APT55_RS22445	COG1309	transcriptional regulator
APT55_RS22450	COG0358	DNA primase activity
APT55_RS22480	COG2234	aminopeptidase activity
APT55_RS22485	COG0824	Thioesterase
APT55_RS22490	COG0589	response to stress
APT55_RS22510	COG2062	phosphohistidine phosphatase, SixA
APT55_RS22550	COG1968	undecaprenyl-diphosphatase activity
APT55_RS22575	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
APT55_RS22585	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
APT55_RS22590	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
APT55_RS22595	COG2048	Heterodisulfide reductase, subunit B
APT55_RS22600	COG0515	serine threonine protein kinase
APT55_RS22605	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
APT55_RS22610	COG2205	protein histidine kinase activity
APT55_RS22615	COG0321	lipoyl(octanoyl) transferase activity
APT55_RS22620	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
APT55_RS22625	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
APT55_RS22655	COG2890	protein-(glutamine-N5) methyltransferase activity
APT55_RS22670	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
APT55_RS22690	COG2119	membrane
APT55_RS22695	COG2119	membrane
APT55_RS22715	COG2201	protein-glutamate methylesterase activity
APT55_RS22720	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
APT55_RS22730	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
APT55_RS22735	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
APT55_RS22750	COG0355	proton-transporting ATP synthase activity, rotational mechanism
APT55_RS22755	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
APT55_RS22760	COG0830	nickel cation binding
APT55_RS22765	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
APT55_RS22775	COG0571	ribonuclease III activity
APT55_RS22805	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
APT55_RS22845	COG1187	pseudouridine synthase activity
APT55_RS22860	COG1324	tolerance protein
APT55_RS22870	COG2091	lysine biosynthetic process via aminoadipic acid
APT55_RS22880	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
APT55_RS22890	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
APT55_RS22905	COG2197	response regulator
APT55_RS22915	COG0411	ABC transporter
APT55_RS22940	COG0330	HflC and HflK could
APT55_RS22955	COG0170	dolichyl monophosphate biosynthetic process
APT55_RS22970	COG0784	Response regulator, receiver
APT55_RS22970	COG2205	protein histidine kinase activity
APT55_RS22975	COG2267	carboxylic ester hydrolase activity
APT55_RS22980	COG0483	inositol monophosphate 1-phosphatase activity
APT55_RS23000	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
APT55_RS23010	COG4310	Domain of unknown function (DUF2172)
APT55_RS23015	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
APT55_RS23030	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
APT55_RS23045	COG1191	sigma factor activity
APT55_RS23085	COG0306	phosphate transporter
APT55_RS23090	COG0697	spore germination
APT55_RS23105	COG1253	flavin adenine dinucleotide binding
APT55_RS23135	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
APT55_RS23150	COG0514	ATP-dependent DNA helicase (RecQ)
APT55_RS23155	COG1028	Short-chain dehydrogenase reductase Sdr
APT55_RS23165	COG0693	protein deglycase activity
APT55_RS23195	COG0116	Belongs to the methyltransferase superfamily
APT55_RS23200	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
APT55_RS23215	COG0628	permease
APT55_RS23260	COG0372	Belongs to the citrate synthase family
APT55_RS23270	COG0402	S-adenosylhomocysteine deaminase activity
APT55_RS23285	COG0297	glycogen (starch) synthase activity
APT55_RS23345	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
APT55_RS23350	COG2124	cytochrome p450
APT55_RS23360	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
APT55_RS23385	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
APT55_RS23430	COG0745	RESPONSE REGULATOR receiver
APT55_RS23440	COG3153	acetyltransferase
APT55_RS23445	COG1040	competence protein
APT55_RS23450	COG0574	Belongs to the PEP-utilizing enzyme family
APT55_RS23450	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
APT55_RS23455	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
APT55_RS23465	COG0617	tRNA 3'-terminal CCA addition
APT55_RS23495	COG2205	protein histidine kinase activity
APT55_RS23495	COG2202	Pas domain
APT55_RS23500	COG0515	serine threonine protein kinase
APT55_RS23510	COG0538	isocitrate dehydrogenase activity
APT55_RS23525	COG0745	RESPONSE REGULATOR receiver
APT55_RS23585	COG0515	serine threonine protein kinase
APT55_RS23585	COG3266	domain, Protein
APT55_RS23600	COG0438	transferase activity, transferring glycosyl groups
APT55_RS23620	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
APT55_RS23625	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
APT55_RS23630	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
APT55_RS23635	COG1575	Belongs to the MenA family. Type 1 subfamily
APT55_RS23645	COG0318	PFAM AMP-dependent synthetase and ligase
APT55_RS23660	COG1012	belongs to the aldehyde dehydrogenase family
APT55_RS23665	COG1716	ATPase activity
APT55_RS23665	COG1131	(ABC) transporter
APT55_RS23665	COG0842	Transport permease protein
APT55_RS23675	COG1196	nuclear chromosome segregation
APT55_RS23710	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
APT55_RS23715	COG3852	Histidine kinase
APT55_RS23730	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
APT55_RS23735	COG0583	DNA-binding transcription factor activity
APT55_RS23745	COG0513	Belongs to the DEAD box helicase family
APT55_RS23750	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
APT55_RS23755	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APT55_RS23780	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
APT55_RS23795	COG3932	Exopolysaccharide synthesis, ExoD
APT55_RS23800	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
APT55_RS23815	COG4555	ABC transporter
APT55_RS23835	COG3956	TIGRFAM MazG family protein
APT55_RS23855	COG3347	Dehydrogenase
APT55_RS23855	COG1028	Short-chain dehydrogenase reductase Sdr
APT55_RS23860	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
APT55_RS23865	COG0227	Belongs to the bacterial ribosomal protein bL28 family
APT55_RS23885	COG4968	Prepilin-type N-terminal cleavage methylation domain
APT55_RS23895	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
APT55_RS23950	COG0596	Alpha beta hydrolase
APT55_RS23960	COG1811	Na channel or pump
APT55_RS23970	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
APT55_RS23975	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
APT55_RS23990	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
APT55_RS23995	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
APT55_RS24040	COG4802	Ferredoxin thioredoxin reductase catalytic beta chain
APT55_RS24045	COG0719	Fe-S assembly protein
APT55_RS24050	COG0396	ATPase activity
APT55_RS24055	COG0719	Fe-S assembly protein
APT55_RS24060	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
APT55_RS24075	COG4680	protein conserved in bacteria
APT55_RS24080	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
APT55_RS24085	COG0275	rRNA processing
APT55_RS24090	COG0649	NAD binding
APT55_RS24105	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
APT55_RS24110	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
APT55_RS24115	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
APT55_RS24125	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
APT55_RS24160	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
APT55_RS24165	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
APT55_RS24180	COG0508	dehydrogenase complex catalyzes the overall conversion of
APT55_RS24180	COG0022	dehydrogenase e1 component
APT55_RS24185	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
APT55_RS24200	COG2202	Pas domain
APT55_RS24200	COG2205	protein histidine kinase activity
APT55_RS24210	COG1480	7TM receptor with intracellular HD hydrolase
APT55_RS24215	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
APT55_RS24220	COG2226	methyltransferase
APT55_RS24230	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
APT55_RS24245	COG2885	chlorophyll binding
APT55_RS24250	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
APT55_RS24255	COG1192	Involved in chromosome partitioning
APT55_RS24275	COG0745	RESPONSE REGULATOR receiver
APT55_RS24285	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
APT55_RS24295	COG0066	3-isopropylmalate dehydratase activity
APT55_RS24300	COG0504	CTP synthase activity
APT55_RS24315	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
APT55_RS24315	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
APT55_RS24350	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
APT55_RS24355	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
APT55_RS24360	COG0515	serine threonine protein kinase
APT55_RS24360	COG4991	sh3 domain protein
APT55_RS24360	COG3064	Membrane
APT55_RS24365	COG0515	serine threonine protein kinase
APT55_RS24370	COG1404	Belongs to the peptidase S8 family
APT55_RS24375	COG1216	Glycosyl transferase, family 2
APT55_RS24375	COG1442	glycosyl transferase family 8
APT55_RS24395	COG1215	transferase activity, transferring glycosyl groups
APT55_RS24435	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
APT55_RS24460	COG0629	single-stranded DNA binding
APT55_RS24465	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
APT55_RS24480	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
APT55_RS24520	COG3629	intracellular signal transduction
APT55_RS24520	COG3903	Transcriptional regulator
APT55_RS24545	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
APT55_RS24555	COG0588	phosphoglycerate mutase activity
APT55_RS24585	COG0768	penicillin binding
APT55_RS24600	COG0167	dihydroorotate dehydrogenase activity
APT55_RS24605	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
APT55_RS24615	COG1215	transferase activity, transferring glycosyl groups
APT55_RS24655	COG0804	urea catabolic process
APT55_RS24675	COG2319	Wd-40 repeat
APT55_RS24680	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
APT55_RS24690	COG3266	domain, Protein
APT55_RS24690	COG0515	serine threonine protein kinase
APT55_RS24705	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
APT55_RS24710	COG0088	Forms part of the polypeptide exit tunnel
APT55_RS24715	COG0089	rRNA binding
APT55_RS24720	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
APT55_RS24725	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
APT55_RS24730	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
APT55_RS24735	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
APT55_RS24740	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
APT55_RS24745	COG0255	Belongs to the universal ribosomal protein uL29 family
APT55_RS24750	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
APT55_RS24755	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
APT55_RS24760	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
APT55_RS24765	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
APT55_RS24770	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
APT55_RS24775	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
APT55_RS24780	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
APT55_RS24785	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
APT55_RS24790	COG0200	Binds to the 23S rRNA
APT55_RS24825	COG2161	toxin-antitoxin pair type II binding
APT55_RS24860	COG2304	oxidoreductase activity
APT55_RS24865	COG1160	GTP binding
APT55_RS24985	COG0604	alcohol dehydrogenase
APT55_RS25000	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
APT55_RS25005	COG1120	ATPase activity
APT55_RS25010	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
APT55_RS25030	COG0848	biopolymer transport protein
APT55_RS25035	COG0811	peptide transport
APT55_RS25055	COG2207	Transcriptional regulator
APT55_RS25065	COG1120	ATPase activity
APT55_RS25070	COG1132	(ABC) transporter
APT55_RS25095	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
APT55_RS25110	COG1132	(ABC) transporter
APT55_RS25120	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
APT55_RS25125	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
APT55_RS25130	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
APT55_RS25170	COG0625	glutathione transferase activity
APT55_RS25185	COG2319	Wd-40 repeat
APT55_RS25185	COG1672	PFAM Archaeal ATPase
APT55_RS25240	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
APT55_RS25240	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
APT55_RS25280	COG0863	Belongs to the N(4) N(6)-methyltransferase family
APT55_RS25285	COG2166	iron-sulfur cluster assembly
APT55_RS25290	COG2340	Cysteine-rich secretory protein family
APT55_RS25295	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
APT55_RS25295	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
APT55_RS25305	COG0784	Response regulator, receiver
APT55_RS25320	COG0840	transmembrane signaling receptor activity
APT55_RS25320	COG2203	Gaf domain
APT55_RS25325	COG0643	Histidine kinase
APT55_RS25325	COG0784	Response regulator, receiver
APT55_RS25325	COG2198	Histidine kinase
APT55_RS25335	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
APT55_RS25335	COG0678	peroxiredoxin activity
APT55_RS25345	COG3118	belongs to the thioredoxin family
APT55_RS25355	COG3932	Exopolysaccharide synthesis, ExoD
APT55_RS25360	COG1361	Conserved repeat domain
APT55_RS25365	COG1253	flavin adenine dinucleotide binding
APT55_RS25375	COG0483	inositol monophosphate 1-phosphatase activity
APT55_RS25395	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
APT55_RS25395	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
APT55_RS25410	COG3180	Ammonia monooxygenase
APT55_RS25420	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
APT55_RS25425	COG1116	anion transmembrane transporter activity
APT55_RS25430	COG0583	DNA-binding transcription factor activity
APT55_RS25455	COG0489	protein tyrosine kinase activity
APT55_RS25460	COG2855	membrane
APT55_RS25470	COG2205	protein histidine kinase activity
APT55_RS25505	COG0438	transferase activity, transferring glycosyl groups
APT55_RS25530	COG1216	Glycosyl transferase, family 2
APT55_RS25545	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
APT55_RS25550	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
APT55_RS25565	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
APT55_RS25585	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
APT55_RS25610	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
APT55_RS25620	COG2814	Major facilitator Superfamily
APT55_RS25625	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
APT55_RS25635	COG0440	acetolactate synthase activity
APT55_RS25640	COG5183	chlorophyll binding
APT55_RS25640	COG2133	pyrroloquinoline quinone binding
APT55_RS25645	COG1193	negative regulation of DNA recombination
APT55_RS25650	COG5002	protein histidine kinase activity
APT55_RS25655	COG4191	Histidine kinase
APT55_RS25670	COG0095	Lipoate-protein ligase
APT55_RS25675	COG0473	3-isopropylmalate dehydrogenase activity
APT55_RS25680	COG0803	Belongs to the bacterial solute-binding protein 9 family
APT55_RS25690	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
APT55_RS25695	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
APT55_RS25700	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
APT55_RS25710	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
APT55_RS25795	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
APT55_RS25840	COG0514	ATP-dependent DNA helicase (RecQ)
APT55_RS25855	COG1131	(ABC) transporter
APT55_RS25865	COG2234	aminopeptidase activity
APT55_RS25870	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
APT55_RS25875	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
APT55_RS25885	COG0482	sulfurtransferase activity
APT55_RS25895	COG0527	aspartate kinase activity
APT55_RS25930	COG1836	PFAM Integral membrane protein DUF92
APT55_RS25935	COG0463	Glycosyl transferase, family 2
APT55_RS25940	COG1657	PFAM Prenyltransferase squalene oxidase
APT55_RS25945	COG0662	Cupin 2, conserved barrel domain protein
APT55_RS25945	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
APT55_RS25950	COG1696	Membrane protein involved in D-alanine export
APT55_RS25965	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
APT55_RS25970	COG0501	Belongs to the peptidase M48B family
APT55_RS26025	COG1385	rRNA (uridine-N3-)-methyltransferase activity
APT55_RS26030	COG1252	NADH dehydrogenase
APT55_RS26060	COG1214	PFAM Peptidase M22, glycoprotease
APT55_RS26085	COG0166	Belongs to the GPI family
APT55_RS26090	COG0501	Belongs to the peptidase M48B family
APT55_RS26100	COG1846	Transcriptional regulator
APT55_RS26105	COG0395	ABC-type sugar transport system, permease component
APT55_RS26115	COG0438	transferase activity, transferring glycosyl groups
APT55_RS26120	COG3291	Pkd domain containing protein
APT55_RS26135	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
APT55_RS26145	COG0384	phenazine biosynthesis protein PhzF
APT55_RS26150	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
APT55_RS26155	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
APT55_RS26160	COG0484	heat shock protein binding
APT55_RS26170	COG1216	Glycosyl transferase, family 2
APT55_RS26170	COG0438	transferase activity, transferring glycosyl groups
APT55_RS26175	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
APT55_RS26175	COG0426	domain, Protein
APT55_RS26180	COG0426	domain, Protein
APT55_RS26180	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
APT55_RS26185	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
APT55_RS26200	COG0519	Catalyzes the synthesis of GMP from XMP
APT55_RS26205	COG1819	glycosyl
APT55_RS26215	COG2345	Transcriptional regulator
APT55_RS26235	COG0724	RNA recognition motif
APT55_RS26265	COG0408	coproporphyrinogen oxidase activity
APT55_RS26275	COG0489	protein tyrosine kinase activity
APT55_RS26280	COG0772	Belongs to the SEDS family
APT55_RS26305	COG0612	Peptidase, M16
APT55_RS26310	COG0612	Peptidase, M16
APT55_RS26325	COG0194	GDP metabolic process
APT55_RS26330	COG2052	Domain of unknown function (DUF370)
APT55_RS26340	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
APT55_RS26345	COG0668	transmembrane transport
APT55_RS26355	COG2337	Toxic component of a toxin-antitoxin (TA) module
APT55_RS26360	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
APT55_RS26375	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
APT55_RS26405	COG2197	response regulator
APT55_RS26415	COG0165	Argininosuccinate lyase
APT55_RS26420	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
APT55_RS26430	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
APT55_RS26445	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
APT55_RS26445	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
APT55_RS26455	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
APT55_RS26460	COG2264	protein methyltransferase activity
APT55_RS26465	COG0531	amino acid
APT55_RS26475	COG0735	belongs to the Fur family
APT55_RS26480	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
APT55_RS26520	COG2084	Dehydrogenase
APT55_RS26525	COG0297	glycogen (starch) synthase activity
APT55_RS26535	COG1840	ABC-type Fe3 transport system, periplasmic component
APT55_RS26540	COG0811	peptide transport
APT55_RS26545	COG0848	biopolymer transport protein
APT55_RS26550	COG0442	prolyl-tRNA aminoacylation
APT55_RS26555	COG0454	-acetyltransferase
APT55_RS26570	COG0640	Transcriptional regulator
APT55_RS26575	COG0673	inositol 2-dehydrogenase activity
APT55_RS26580	COG1215	transferase activity, transferring glycosyl groups
APT55_RS26605	COG0589	response to stress
APT55_RS26645	COG0783	Belongs to the Dps family
APT55_RS26650	COG0635	Involved in the biosynthesis of porphyrin-containing compound
APT55_RS26655	COG4956	integral membrane protein (PIN domain superfamily)
APT55_RS26665	COG1218	3'(2'),5'-bisphosphate nucleotidase
APT55_RS26670	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
APT55_RS26680	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
APT55_RS26685	COG1045	serine acetyltransferase
APT55_RS26725	COG0071	Belongs to the small heat shock protein (HSP20) family
APT55_RS26730	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
APT55_RS26735	COG0463	Glycosyl transferase, family 2
APT55_RS26740	COG0564	pseudouridine synthase activity
APT55_RS26755	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
APT55_RS26775	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
APT55_RS26775	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
APT55_RS26780	COG1562	ergosterol biosynthetic process
APT55_RS26790	COG0129	dihydroxy-acid dehydratase activity
APT55_RS26825	COG3852	Histidine kinase
APT55_RS26835	COG0288	reversible hydration of carbon dioxide
APT55_RS26850	COG1950	PFAM Membrane protein of
APT55_RS26860	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APT55_RS26885	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
APT55_RS26905	COG3845	ABC transporter
APT55_RS26910	COG1079	Belongs to the binding-protein-dependent transport system permease family
APT55_RS26915	COG4603	Belongs to the binding-protein-dependent transport system permease family
APT55_RS26925	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
APT55_RS26955	COG0579	oxidoreductase
APT55_RS26975	COG1446	asparaginase
APT55_RS26985	COG3977	Valine--pyruvate aminotransferase
APT55_RS26990	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
APT55_RS27005	COG0668	transmembrane transport
APT55_RS27045	COG1672	PFAM Archaeal ATPase
APT55_RS27045	COG2319	Wd-40 repeat
APT55_RS27060	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
APT55_RS27080	COG3852	Histidine kinase
APT55_RS27085	COG0745	RESPONSE REGULATOR receiver
APT55_RS27090	COG5002	protein histidine kinase activity
APT55_RS27090	COG5000	phosphorelay sensor kinase activity
APT55_RS27115	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
APT55_RS27170	COG0783	Belongs to the Dps family
APT55_RS27185	COG3903	Transcriptional regulator
APT55_RS27185	COG3629	intracellular signal transduction
APT55_RS27210	COG2124	cytochrome p450
APT55_RS27215	COG1169	isochorismate synthase
APT55_RS27225	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
APT55_RS27230	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
APT55_RS27235	COG1397	ADP-ribosylglycohydrolase
APT55_RS27250	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
APT55_RS27255	COG0484	heat shock protein binding
APT55_RS27265	COG0745	RESPONSE REGULATOR receiver
APT55_RS27270	COG5002	protein histidine kinase activity
APT55_RS27275	COG1187	pseudouridine synthase activity
APT55_RS27280	COG1426	Protein conserved in bacteria
APT55_RS27285	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
APT55_RS27295	COG1615	UPF0182 protein
APT55_RS27310	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
APT55_RS27315	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
APT55_RS27340	COG2045	Belongs to the ComB family
APT55_RS27355	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
APT55_RS27365	COG4783	chaperone-mediated protein folding
APT55_RS27370	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
APT55_RS27385	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
APT55_RS27390	COG1361	Conserved repeat domain
APT55_RS27390	COG3266	domain, Protein
APT55_RS27390	COG2911	Protein conserved in bacteria
APT55_RS27490	COG0631	protein serine/threonine phosphatase activity
APT55_RS27495	COG0515	serine threonine protein kinase
APT55_RS27495	COG2815	serine threonine protein kinase
APT55_RS27515	COG0515	serine threonine protein kinase
APT55_RS27515	COG2815	serine threonine protein kinase
APT55_RS27520	COG0515	serine threonine protein kinase
APT55_RS27520	COG2815	serine threonine protein kinase
APT55_RS27525	COG0515	serine threonine protein kinase
APT55_RS27525	COG2815	serine threonine protein kinase
APT55_RS27590	COG2226	methyltransferase
APT55_RS27605	COG4603	Belongs to the binding-protein-dependent transport system permease family
APT55_RS27610	COG3845	ABC transporter
APT55_RS27625	COG0723	plastoquinol--plastocyanin reductase activity
APT55_RS27680	COG0671	phosphoesterase, PA-phosphatase related
APT55_RS27700	COG4636	protein conserved in cyanobacteria
APT55_RS27705	COG1842	Phage shock protein A
APT55_RS27710	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
APT55_RS27730	COG1741	Belongs to the pirin family
APT55_RS27735	COG0745	RESPONSE REGULATOR receiver
APT55_RS27780	COG0517	IMP dehydrogenase activity
APT55_RS27780	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
APT55_RS27785	COG1696	Membrane protein involved in D-alanine export
APT55_RS27795	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
APT55_RS27805	COG5183	chlorophyll binding
APT55_RS27805	COG2133	pyrroloquinoline quinone binding
APT55_RS27810	COG2877	3-deoxy-8-phosphooctulonate synthase activity
APT55_RS27815	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
APT55_RS27830	COG1216	Glycosyl transferase, family 2
APT55_RS27835	COG1215	transferase activity, transferring glycosyl groups
APT55_RS27840	COG0438	transferase activity, transferring glycosyl groups
APT55_RS27850	COG1216	Glycosyl transferase, family 2
APT55_RS27870	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
APT55_RS27885	COG0438	transferase activity, transferring glycosyl groups
APT55_RS27890	COG0438	transferase activity, transferring glycosyl groups
APT55_RS27930	COG0110	maltose O-acetyltransferase activity
APT55_RS27935	COG1216	Glycosyl transferase, family 2
APT55_RS27945	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
APT55_RS27950	COG0745	RESPONSE REGULATOR receiver
APT55_RS27965	COG0110	maltose O-acetyltransferase activity
APT55_RS27970	COG2084	Dehydrogenase
APT55_RS27980	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
APT55_RS27990	COG1085	galactose-1-phosphate uridylyltransferase
APT55_RS27995	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
APT55_RS28015	COG0246	Mannitol dehydrogenase
APT55_RS28030	COG1301	dicarboxylic acid transport
APT55_RS28040	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
APT55_RS28045	COG5002	protein histidine kinase activity
APT55_RS28085	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
APT55_RS28125	COG1262	PFAM Formylglycine-generating sulfatase enzyme
APT55_RS28135	COG3059	membrane
APT55_RS28155	COG2146	nitrite reductase [NAD(P)H] activity
APT55_RS28165	COG0745	RESPONSE REGULATOR receiver
APT55_RS28170	COG5002	protein histidine kinase activity
APT55_RS28175	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
APT55_RS28180	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
APT55_RS28205	COG1830	Aldolase
APT55_RS28210	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
APT55_RS28215	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
APT55_RS28220	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
APT55_RS28225	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
APT55_RS28230	COG0837	glucose binding
APT55_RS28240	COG0837	glucose binding
APT55_RS28245	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
APT55_RS28265	COG3852	Histidine kinase
APT55_RS28270	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
APT55_RS28270	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
APT55_RS28275	COG1028	Short-chain dehydrogenase reductase Sdr
APT55_RS28290	COG2197	response regulator
APT55_RS28295	COG4585	Histidine kinase
APT55_RS28310	COG0745	RESPONSE REGULATOR receiver
APT55_RS28330	COG0697	spore germination
APT55_RS28355	COG0745	RESPONSE REGULATOR receiver
APT55_RS28360	COG5002	protein histidine kinase activity
APT55_RS28365	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
APT55_RS28370	COG3852	Histidine kinase
APT55_RS28390	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
APT55_RS28400	COG1672	PFAM Archaeal ATPase
APT55_RS28400	COG2319	Wd-40 repeat
APT55_RS28525	COG4585	Histidine kinase
APT55_RS28530	COG2197	response regulator
APT55_RS28555	COG1266	CAAX protease self-immunity
APT55_RS28630	COG1404	Belongs to the peptidase S8 family
APT55_RS28660	COG3852	Histidine kinase
APT55_RS28670	COG4584	PFAM Integrase catalytic
APT55_RS28675	COG1484	DNA-dependent DNA replication
APT55_RS28730	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
APT55_RS28760	COG0693	protein deglycase activity
APT55_RS28790	COG3795	YCII-related domain
APT55_RS28795	COG4941	Belongs to the sigma-70 factor family
APT55_RS28820	COG4243	Vitamin k epoxide reductase
APT55_RS28825	COG1606	tRNA processing
APT55_RS28845	COG0220	tRNA (guanine-N7-)-methyltransferase activity
APT55_RS28855	COG5001	Diguanylate cyclase
APT55_RS28855	COG4251	negative regulation of phosphorylation
APT55_RS28855	COG3706	GGDEF domain
APT55_RS28855	COG2203	Gaf domain
APT55_RS28860	COG0784	Response regulator, receiver
APT55_RS28870	COG5002	protein histidine kinase activity
APT55_RS28885	COG3903	Transcriptional regulator
APT55_RS28885	COG2319	Wd-40 repeat
APT55_RS28920	COG0010	Belongs to the arginase family
APT55_RS28925	COG0495	leucyl-tRNA aminoacylation
APT55_RS28930	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
APT55_RS28960	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
APT55_RS28965	COG3118	belongs to the thioredoxin family
APT55_RS28985	COG0405	Gamma-glutamyltransferase
APT55_RS28990	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
APT55_RS29000	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
APT55_RS29005	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
APT55_RS29015	COG2197	response regulator
APT55_RS29020	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
APT55_RS29025	COG0746	molybdenum cofactor guanylyltransferase activity
APT55_RS29040	COG5002	protein histidine kinase activity
APT55_RS29045	COG0745	RESPONSE REGULATOR receiver
APT55_RS29050	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
APT55_RS29055	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
APT55_RS29060	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
APT55_RS29110	COG2066	Belongs to the glutaminase family
APT55_RS29115	COG1472	Belongs to the glycosyl hydrolase 3 family
APT55_RS29120	COG0123	including yeast histone deacetylase and acetoin utilization protein
APT55_RS29135	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
APT55_RS29150	COG0820	rRNA (adenine-C2-)-methyltransferase activity
APT55_RS29155	COG2202	Pas domain
APT55_RS29155	COG2205	protein histidine kinase activity
APT55_RS29160	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
APT55_RS29165	COG1335	isochorismatase
APT55_RS29175	COG2205	protein histidine kinase activity
APT55_RS29200	COG0515	serine threonine protein kinase
APT55_RS29200	COG3266	domain, Protein
APT55_RS29210	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
APT55_RS29215	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
APT55_RS29215	COG3320	Male sterility
APT55_RS29225	COG4581	dead DEAH box helicase
APT55_RS29320	COG0484	heat shock protein binding
APT55_RS29385	COG0582	viral genome integration into host DNA
APT55_RS29405	COG0776	regulation of translation
APT55_RS29670	COG1192	Involved in chromosome partitioning
APT55_RS29840	COG1401	restriction endodeoxyribonuclease activity
APT55_RS29935	COG4974	Belongs to the 'phage' integrase family
APT55_RS29945	COG2274	protein secretion by the type I secretion system
APT55_RS29950	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APT55_RS29990	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
APT55_RS29995	COG0470	DNA polymerase III
APT55_RS30020	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
APT55_RS30075	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
APT55_RS30100	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
APT55_RS30115	COG1396	sequence-specific DNA binding
APT55_RS30120	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
APT55_RS30140	COG0464	growth
APT55_RS30175	COG4804	nuclease activity
APT55_RS30210	COG1846	Transcriptional regulator
APT55_RS30265	COG3795	YCII-related domain
APT55_RS30270	COG4941	Belongs to the sigma-70 factor family
APT55_RS30310	COG0625	glutathione transferase activity
APT55_RS30335	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
APT55_RS30355	COG2226	methyltransferase
APT55_RS30475	COG3340	Belongs to the peptidase S51 family
APT55_RS30535	COG2274	protein secretion by the type I secretion system
APT55_RS30550	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
APT55_RS30560	COG0515	serine threonine protein kinase
APT55_RS30560	COG3266	domain, Protein
APT55_RS30625	COG2124	cytochrome p450
APT55_RS30670	COG4584	PFAM Integrase catalytic
APT55_RS30675	COG1484	DNA-dependent DNA replication
APT55_RS30760	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
APT55_RS30770	COG0783	Belongs to the Dps family
APT55_RS30780	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
APT55_RS30785	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
APT55_RS30790	COG4988	ABC transporter
APT55_RS30795	COG0390	transport system, permease component
APT55_RS30815	COG4771	TonB-dependent receptor
APT55_RS30855	COG0745	RESPONSE REGULATOR receiver
APT55_RS30865	COG5002	protein histidine kinase activity
APT55_RS30870	COG2198	Histidine kinase
APT55_RS30870	COG0784	Response regulator, receiver
APT55_RS30870	COG5002	protein histidine kinase activity
APT55_RS30880	COG0784	Response regulator, receiver
APT55_RS30880	COG2205	protein histidine kinase activity
APT55_RS30900	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
APT55_RS30925	COG1079	Belongs to the binding-protein-dependent transport system permease family
APT55_RS30935	COG3845	ABC transporter
APT55_RS30950	COG0784	Response regulator, receiver
APT55_RS30950	COG5002	protein histidine kinase activity
APT55_RS30955	COG2815	serine threonine protein kinase
APT55_RS30955	COG0515	serine threonine protein kinase
APT55_RS30965	COG0784	Response regulator, receiver
APT55_RS30965	COG2205	protein histidine kinase activity
APT55_RS31075	COG1475	DNA binding
APT55_RS31085	COG1192	Involved in chromosome partitioning
APT55_RS31105	COG1192	Involved in chromosome partitioning
APT55_RS31125	COG2003	Belongs to the UPF0758 family
APT55_RS31215	COG2003	Belongs to the UPF0758 family
APT55_RS31240	COG4804	nuclease activity
APT55_RS31290	COG1484	DNA-dependent DNA replication
APT55_RS31295	COG4584	PFAM Integrase catalytic
APT55_RS31310	COG3903	Transcriptional regulator
APT55_RS31310	COG3629	intracellular signal transduction
APT55_RS31345	COG2329	Antibiotic biosynthesis monooxygenase
APT55_RS31350	COG0758	DNA mediated transformation
APT55_RS31350	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
APT55_RS31375	COG1525	nuclease
APT55_RS31440	COG1468	defense response to virus
APT55_RS31440	COG1518	maintenance of DNA repeat elements
APT55_RS31485	COG4584	PFAM Integrase catalytic
APT55_RS31490	COG1484	DNA-dependent DNA replication
APT55_RS31500	COG3179	chitinase
APT55_RS31520	COG2319	Wd-40 repeat
APT55_RS31520	COG1672	PFAM Archaeal ATPase
APT55_RS31545	COG3903	Transcriptional regulator
APT55_RS31545	COG2319	Wd-40 repeat
APT55_RS31745	COG1192	Involved in chromosome partitioning
APT55_RS31825	COG1136	(ABC) transporter
APT55_RS31825	COG0577	efflux transmembrane transporter activity
APT55_RS31830	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APT55_RS31835	COG2197	response regulator
APT55_RS31850	COG2274	protein secretion by the type I secretion system
APT55_RS31855	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APT55_RS31860	COG2274	protein secretion by the type I secretion system
APT55_RS31865	COG0728	peptidoglycan biosynthetic process