locus-tag	class	description
GFS31_RS00020	COG0072	phenylalanine-tRNA ligase activity
GFS31_RS00035	COG0784	Response regulator, receiver
GFS31_RS00050	COG0840	transmembrane signaling receptor activity
GFS31_RS00055	COG2198	Histidine kinase
GFS31_RS00055	COG0784	Response regulator, receiver
GFS31_RS00055	COG0643	Histidine kinase
GFS31_RS00085	COG2319	Wd-40 repeat
GFS31_RS00085	COG4249	Peptidase C14 caspase catalytic subunit p20
GFS31_RS00095	COG1487	ribonuclease activity
GFS31_RS00105	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GFS31_RS00110	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GFS31_RS00115	COG3781	membrane
GFS31_RS00120	COG0515	serine threonine protein kinase
GFS31_RS00135	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
GFS31_RS00140	COG3842	ATPase activity
GFS31_RS00145	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GFS31_RS00150	COG1959	2 iron, 2 sulfur cluster binding
GFS31_RS00165	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
GFS31_RS00185	COG0372	Belongs to the citrate synthase family
GFS31_RS00190	COG0724	RNA recognition motif
GFS31_RS00195	COG0828	Belongs to the bacterial ribosomal protein bS21 family
GFS31_RS00200	COG0156	8-amino-7-oxononanoate synthase activity
GFS31_RS00205	COG1166	arginine decarboxylase activity
GFS31_RS00225	COG2205	protein histidine kinase activity
GFS31_RS00225	COG0784	Response regulator, receiver
GFS31_RS00230	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GFS31_RS00240	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GFS31_RS00245	COG2226	methyltransferase
GFS31_RS00245	COG1073	alpha beta
GFS31_RS00255	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GFS31_RS00270	COG0505	Belongs to the CarA family
GFS31_RS00295	COG1234	tRNA 3'-trailer cleavage
GFS31_RS00305	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GFS31_RS00330	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GFS31_RS00335	COG0494	nUDIX hydrolase
GFS31_RS00345	COG3842	ATPase activity
GFS31_RS00355	COG0459	protein refolding
GFS31_RS00360	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GFS31_RS00390	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
GFS31_RS00395	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
GFS31_RS00400	COG2363	Small membrane protein
GFS31_RS00435	COG0587	DNA-directed DNA polymerase activity
GFS31_RS00480	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GFS31_RS00485	COG0237	dephospho-CoA kinase activity
GFS31_RS00500	COG0004	ammonium transporteR
GFS31_RS00505	COG4636	protein conserved in cyanobacteria
GFS31_RS00510	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GFS31_RS00520	COG0723	plastoquinol--plastocyanin reductase activity
GFS31_RS00525	COG3258	Cytochrome c
GFS31_RS00530	COG1217	gtp-binding protein TYPA
GFS31_RS00545	COG0561	phosphatase activity
GFS31_RS00550	COG3001	Fructosamine kinase
GFS31_RS00600	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GFS31_RS00630	COG1361	Conserved repeat domain
GFS31_RS00635	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
GFS31_RS00665	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GFS31_RS00685	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
GFS31_RS00705	COG2233	PERMEase
GFS31_RS00710	COG3659	wide pore channel activity
GFS31_RS00715	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
GFS31_RS00725	COG0811	peptide transport
GFS31_RS00755	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GFS31_RS00760	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GFS31_RS00765	COG0004	ammonium transporteR
GFS31_RS00790	COG0347	Belongs to the P(II) protein family
GFS31_RS00795	COG0784	Response regulator, receiver
GFS31_RS00805	COG0322	excinuclease ABC activity
GFS31_RS00810	COG0288	reversible hydration of carbon dioxide
GFS31_RS00835	COG0116	Belongs to the methyltransferase superfamily
GFS31_RS00840	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
GFS31_RS00845	COG3437	response regulator, receiver
GFS31_RS00850	COG5002	protein histidine kinase activity
GFS31_RS00865	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GFS31_RS00880	COG1253	flavin adenine dinucleotide binding
GFS31_RS00885	COG0673	inositol 2-dehydrogenase activity
GFS31_RS00890	COG1376	ErfK ybiS ycfS ynhG family protein
GFS31_RS00895	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GFS31_RS00905	COG4603	Belongs to the binding-protein-dependent transport system permease family
GFS31_RS00910	COG1079	Belongs to the binding-protein-dependent transport system permease family
GFS31_RS00935	COG2094	Belongs to the DNA glycosylase MPG family
GFS31_RS00955	COG0114	fumarate hydratase activity
GFS31_RS00960	COG0612	Peptidase, M16
GFS31_RS00965	COG0612	Peptidase, M16
GFS31_RS00975	COG0435	Glutathione S-transferase
GFS31_RS01020	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
GFS31_RS01045	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
GFS31_RS01055	COG1252	NADH dehydrogenase
GFS31_RS01060	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
GFS31_RS01085	COG1090	epimerase
GFS31_RS01090	COG0259	pyridoxamine-phosphate oxidase activity
GFS31_RS01100	COG0463	Glycosyl transferase, family 2
GFS31_RS01105	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GFS31_RS01110	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GFS31_RS01135	COG1376	ErfK ybiS ycfS ynhG family protein
GFS31_RS01175	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GFS31_RS01175	COG2022	thiamine diphosphate biosynthetic process
GFS31_RS01180	COG0189	ligase activity
GFS31_RS01185	COG0668	transmembrane transport
GFS31_RS01195	COG1316	TRANSCRIPTIONal
GFS31_RS01205	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GFS31_RS01210	COG4597	amino acid ABC transporter
GFS31_RS01215	COG0765	amino acid transport
GFS31_RS01220	COG1126	abc transporter atp-binding protein
GFS31_RS01225	COG0205	6-phosphofructokinase activity
GFS31_RS01230	COG0737	Belongs to the 5'-nucleotidase family
GFS31_RS01235	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GFS31_RS01265	COG0516	GMP reductase activity
GFS31_RS01265	COG0517	IMP dehydrogenase activity
GFS31_RS01270	COG1575	Belongs to the MenA family. Type 1 subfamily
GFS31_RS01275	COG4948	Mandelate Racemase Muconate Lactonizing
GFS31_RS01280	COG0318	PFAM AMP-dependent synthetase and ligase
GFS31_RS01285	COG0312	modulator of DNA gyrase
GFS31_RS01290	COG0312	modulator of DNA gyrase
GFS31_RS01300	COG1132	(ABC) transporter
GFS31_RS01310	COG1487	ribonuclease activity
GFS31_RS01315	COG1487	ribonuclease activity
GFS31_RS01335	COG0572	uridine kinase
GFS31_RS01340	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GFS31_RS01345	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GFS31_RS01370	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GFS31_RS01375	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GFS31_RS01380	COG1845	cytochrome c oxidase, subunit III
GFS31_RS01385	COG0583	DNA-binding transcription factor activity
GFS31_RS01400	COG2211	Major facilitator Superfamily
GFS31_RS01410	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GFS31_RS01420	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GFS31_RS01430	COG0596	Alpha beta hydrolase
GFS31_RS01435	COG5001	Diguanylate cyclase
GFS31_RS01435	COG4251	negative regulation of phosphorylation
GFS31_RS01435	COG2203	Gaf domain
GFS31_RS01435	COG3706	GGDEF domain
GFS31_RS01445	COG0564	pseudouridine synthase activity
GFS31_RS01450	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GFS31_RS01460	COG2119	membrane
GFS31_RS01475	COG4221	oxidoreductase activity
GFS31_RS01480	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GFS31_RS01490	COG0784	Response regulator, receiver
GFS31_RS01495	COG4251	negative regulation of phosphorylation
GFS31_RS01500	COG0784	Response regulator, receiver
GFS31_RS01535	COG0179	Fumarylacetoacetate (FAA) hydrolase
GFS31_RS01540	COG0360	Binds together with S18 to 16S ribosomal RNA
GFS31_RS01565	COG0181	hydroxymethylbilane synthase activity
GFS31_RS01580	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
GFS31_RS01635	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GFS31_RS01650	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GFS31_RS01680	COG3224	Antibiotic biosynthesis monooxygenase
GFS31_RS01685	COG3224	Antibiotic biosynthesis monooxygenase
GFS31_RS01695	COG2010	Cytochrome c
GFS31_RS01715	COG0706	membrane insertase activity
GFS31_RS01725	COG0594	ribonuclease P activity
GFS31_RS01730	COG0230	Belongs to the bacterial ribosomal protein bL34 family
GFS31_RS01735	COG0750	zinc metalloprotease
GFS31_RS01740	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GFS31_RS01745	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GFS31_RS01750	COG0052	Belongs to the universal ribosomal protein uS2 family
GFS31_RS01755	COG0542	response to heat
GFS31_RS01800	COG0402	S-adenosylhomocysteine deaminase activity
GFS31_RS01810	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GFS31_RS01820	COG0829	nickel cation binding
GFS31_RS01835	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GFS31_RS01845	COG0735	belongs to the Fur family
GFS31_RS01865	COG2239	Acts as a magnesium transporter
GFS31_RS01870	COG1285	pathogenesis
GFS31_RS01890	COG0322	excinuclease ABC activity
GFS31_RS01895	COG0723	plastoquinol--plastocyanin reductase activity
GFS31_RS01895	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GFS31_RS01920	COG0835	chemotaxis
GFS31_RS01920	COG0784	Response regulator, receiver
GFS31_RS01925	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GFS31_RS01930	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GFS31_RS01940	COG0450	alkyl hydroperoxide reductase
GFS31_RS01960	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GFS31_RS01960	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GFS31_RS01965	COG0612	Peptidase, M16
GFS31_RS01985	COG0582	viral genome integration into host DNA
GFS31_RS01990	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
GFS31_RS02000	COG0010	Belongs to the arginase family
GFS31_RS02020	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GFS31_RS02040	COG0714	Associated with various cellular activities
GFS31_RS02090	COG1487	ribonuclease activity
GFS31_RS02115	COG4636	protein conserved in cyanobacteria
GFS31_RS02135	COG0542	response to heat
GFS31_RS02195	COG0517	IMP dehydrogenase activity
GFS31_RS02195	COG0617	tRNA 3'-terminal CCA addition
GFS31_RS02195	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
GFS31_RS02205	COG3937	granule-associated protein
GFS31_RS02210	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GFS31_RS02215	COG0631	protein serine/threonine phosphatase activity
GFS31_RS02220	COG1496	oxidoreductase activity
GFS31_RS02225	COG0484	heat shock protein binding
GFS31_RS02230	COG0628	permease
GFS31_RS02240	COG0828	Belongs to the bacterial ribosomal protein bS21 family
GFS31_RS02245	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GFS31_RS02250	COG0475	glutathione-regulated potassium exporter activity
GFS31_RS02260	COG0429	hydrolase of the alpha beta-hydrolase fold
GFS31_RS02265	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
GFS31_RS02280	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GFS31_RS02300	COG1012	belongs to the aldehyde dehydrogenase family
GFS31_RS02320	COG0450	alkyl hydroperoxide reductase
GFS31_RS02330	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
GFS31_RS02335	COG0352	thiamine-phosphate diphosphorylase activity
GFS31_RS02345	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
GFS31_RS02350	COG0006	proline dipeptidase activity
GFS31_RS02360	COG1836	PFAM Integral membrane protein DUF92
GFS31_RS02370	COG2204	response regulator
GFS31_RS02370	COG5564	TIM-barrel signal transduction protein
GFS31_RS02400	COG3290	protein histidine kinase activity
GFS31_RS02400	COG0840	transmembrane signaling receptor activity
GFS31_RS02415	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
GFS31_RS02420	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
GFS31_RS02425	COG0328	RNA-DNA hybrid ribonuclease activity
GFS31_RS02460	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GFS31_RS02475	COG0745	RESPONSE REGULATOR receiver
GFS31_RS02490	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GFS31_RS02505	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GFS31_RS02530	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GFS31_RS02535	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GFS31_RS02540	COG0793	Belongs to the peptidase S41A family
GFS31_RS02560	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GFS31_RS02565	COG2010	Cytochrome c
GFS31_RS02580	COG2217	Heavy metal translocating P-type atpase
GFS31_RS02585	COG0589	response to stress
GFS31_RS02585	COG0475	glutathione-regulated potassium exporter activity
GFS31_RS02610	COG1366	Belongs to the anti-sigma-factor antagonist family
GFS31_RS02620	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
GFS31_RS02635	COG1012	belongs to the aldehyde dehydrogenase family
GFS31_RS02650	COG0402	S-adenosylhomocysteine deaminase activity
GFS31_RS02680	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GFS31_RS02700	COG2885	chlorophyll binding
GFS31_RS02710	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GFS31_RS02715	COG2226	methyltransferase
GFS31_RS02720	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GFS31_RS02735	COG0860	N-Acetylmuramoyl-L-alanine amidase
GFS31_RS02745	COG3239	Fatty acid desaturase
GFS31_RS02770	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GFS31_RS02815	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GFS31_RS02820	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GFS31_RS02825	COG0022	dehydrogenase e1 component
GFS31_RS02825	COG0508	dehydrogenase complex catalyzes the overall conversion of
GFS31_RS02830	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GFS31_RS02835	COG0484	heat shock protein binding
GFS31_RS02855	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GFS31_RS02860	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
GFS31_RS02890	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GFS31_RS02920	COG1429	ligase activity, forming nitrogen-metal bonds
GFS31_RS02930	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GFS31_RS02930	COG0426	domain, Protein
GFS31_RS02940	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GFS31_RS02940	COG0426	domain, Protein
GFS31_RS02945	COG0488	(ABC) transporter
GFS31_RS02955	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GFS31_RS02960	COG2252	PERMEase
GFS31_RS02975	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
GFS31_RS02980	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GFS31_RS02985	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GFS31_RS03005	COG1408	metallophosphoesterase
GFS31_RS03020	COG1606	tRNA processing
GFS31_RS03025	COG0837	glucose binding
GFS31_RS03040	COG0415	Belongs to the DNA photolyase family
GFS31_RS03060	COG1131	(ABC) transporter
GFS31_RS03070	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
GFS31_RS03075	COG5322	oxidoreductase activity
GFS31_RS03095	COG0038	chloride channel
GFS31_RS03105	COG0659	secondary active sulfate transmembrane transporter activity
GFS31_RS03110	COG0475	glutathione-regulated potassium exporter activity
GFS31_RS03120	COG1006	Multisubunit Na H antiporter MnhC subunit
GFS31_RS03125	COG0651	ATP synthesis coupled electron transport
GFS31_RS03130	COG0651	ATP synthesis coupled electron transport
GFS31_RS03175	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GFS31_RS03180	COG0454	-acetyltransferase
GFS31_RS03195	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GFS31_RS03205	COG0515	serine threonine protein kinase
GFS31_RS03210	COG3411	Ferredoxin
GFS31_RS03220	COG2894	cell division
GFS31_RS03240	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
GFS31_RS03250	COG1957	nucleoside hydrolase
GFS31_RS03275	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GFS31_RS03280	COG0351	phosphomethylpyrimidine kinase
GFS31_RS03305	COG0489	protein tyrosine kinase activity
GFS31_RS03310	COG0772	Belongs to the SEDS family
GFS31_RS03320	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GFS31_RS03335	COG0583	DNA-binding transcription factor activity
GFS31_RS03405	COG1799	cell septum assembly
GFS31_RS03430	COG0740	serine-type endopeptidase activity
GFS31_RS03435	COG0740	serine-type endopeptidase activity
GFS31_RS03455	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GFS31_RS03490	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GFS31_RS03500	COG0746	molybdenum cofactor guanylyltransferase activity
GFS31_RS03505	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
GFS31_RS03510	COG1028	Short-chain dehydrogenase reductase Sdr
GFS31_RS03530	COG1615	UPF0182 protein
GFS31_RS03575	COG0066	3-isopropylmalate dehydratase activity
GFS31_RS03585	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
GFS31_RS03620	COG3259	Nickel-dependent hydrogenase
GFS31_RS03630	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GFS31_RS03670	COG0540	Belongs to the ATCase OTCase family
GFS31_RS03680	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
GFS31_RS03680	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GFS31_RS03690	COG0745	RESPONSE REGULATOR receiver
GFS31_RS03695	COG0387	Pfam Sodium calcium exchanger
GFS31_RS03700	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GFS31_RS03705	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GFS31_RS03710	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GFS31_RS03725	COG2059	Chromate
GFS31_RS03735	COG0613	PHP domain protein
GFS31_RS03770	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
GFS31_RS03940	COG0322	excinuclease ABC activity
GFS31_RS03945	COG0582	viral genome integration into host DNA
GFS31_RS03965	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
GFS31_RS03970	COG1468	defense response to virus
GFS31_RS03970	COG1518	maintenance of DNA repeat elements
GFS31_RS03980	COG1857	crispr-associated protein
GFS31_RS03995	COG1203	CRISPR-associated helicase, Cas3
GFS31_RS04005	COG2378	regulation of single-species biofilm formation
GFS31_RS04075	COG0762	integral membrane protein
GFS31_RS04085	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GFS31_RS04095	COG0671	phosphoesterase, PA-phosphatase related
GFS31_RS04105	COG1446	asparaginase
GFS31_RS04115	COG0023	Translation Initiation Factor
GFS31_RS04120	COG0589	response to stress
GFS31_RS04120	COG0475	glutathione-regulated potassium exporter activity
GFS31_RS04150	COG0525	valine-tRNA ligase activity
GFS31_RS04170	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GFS31_RS04180	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
GFS31_RS04190	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GFS31_RS04195	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GFS31_RS04205	COG0009	L-threonylcarbamoyladenylate synthase
GFS31_RS04210	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
GFS31_RS04215	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GFS31_RS04225	COG0438	transferase activity, transferring glycosyl groups
GFS31_RS04235	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
GFS31_RS04240	COG0343	queuine tRNA-ribosyltransferase activity
GFS31_RS04255	COG0534	Mate efflux family protein
GFS31_RS04260	COG0123	including yeast histone deacetylase and acetoin utilization protein
GFS31_RS04285	COG0745	RESPONSE REGULATOR receiver
GFS31_RS04295	COG0745	RESPONSE REGULATOR receiver
GFS31_RS04300	COG5001	Diguanylate cyclase
GFS31_RS04300	COG1716	ATPase activity
GFS31_RS04310	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GFS31_RS04325	COG0333	Belongs to the bacterial ribosomal protein bL32 family
GFS31_RS04330	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GFS31_RS04335	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
GFS31_RS04350	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GFS31_RS04365	COG2319	Wd-40 repeat
GFS31_RS04365	COG1672	PFAM Archaeal ATPase
GFS31_RS04370	COG0649	NAD binding
GFS31_RS04405	COG0739	heme binding
GFS31_RS04410	COG1619	proteins homologs of microcin C7 resistance protein MccF
GFS31_RS04415	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GFS31_RS04425	COG1403	HNH endonuclease
GFS31_RS04435	COG0552	protein localization to endoplasmic reticulum
GFS31_RS04450	COG1022	Amp-dependent synthetase and ligase
GFS31_RS04455	COG0137	argininosuccinate synthase activity
GFS31_RS04460	COG1994	Peptidase M50
GFS31_RS04460	COG0517	IMP dehydrogenase activity
GFS31_RS04470	COG0135	phosphoribosylanthranilate isomerase activity
GFS31_RS04480	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GFS31_RS04485	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
GFS31_RS04490	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GFS31_RS04495	COG0539	negative regulation of cytoplasmic translation
GFS31_RS04510	COG1160	GTP binding
GFS31_RS04515	COG5001	Diguanylate cyclase
GFS31_RS04520	COG0469	pyruvate kinase activity
GFS31_RS04525	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
GFS31_RS04530	COG3093	addiction module antidote protein HigA
GFS31_RS04545	COG3536	Protein conserved in bacteria
GFS31_RS04550	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GFS31_RS04565	COG3437	response regulator, receiver
GFS31_RS04580	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GFS31_RS04585	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
GFS31_RS04605	COG0416	fatty acid biosynthetic process
GFS31_RS04610	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GFS31_RS04620	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GFS31_RS04625	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GFS31_RS04630	COG2264	protein methyltransferase activity
GFS31_RS04635	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GFS31_RS04640	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GFS31_RS04645	COG0583	DNA-binding transcription factor activity
GFS31_RS04660	COG2361	Protein of unknown function DUF86
GFS31_RS04685	COG0673	inositol 2-dehydrogenase activity
GFS31_RS04695	COG4581	dead DEAH box helicase
GFS31_RS04705	COG1803	Methylglyoxal synthase
GFS31_RS04705	COG1597	lipid kinase activity
GFS31_RS04720	COG0571	ribonuclease III activity
GFS31_RS04730	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GFS31_RS04770	COG2226	methyltransferase
GFS31_RS04795	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GFS31_RS04800	COG0724	RNA recognition motif
GFS31_RS04805	COG2205	protein histidine kinase activity
GFS31_RS04810	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
GFS31_RS04815	COG1304	FMN binding
GFS31_RS04840	COG0308	aminopeptidase N
GFS31_RS04845	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GFS31_RS04850	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GFS31_RS04865	COG1490	D-aminoacyl-tRNA deacylase activity
GFS31_RS04875	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GFS31_RS04880	COG0457	Tetratricopeptide repeat
GFS31_RS04885	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GFS31_RS04895	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GFS31_RS04900	COG0583	DNA-binding transcription factor activity
GFS31_RS04910	COG0601	transmembrane transport
GFS31_RS04920	COG0316	Belongs to the HesB IscA family
GFS31_RS04930	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
GFS31_RS04935	COG0542	response to heat
GFS31_RS04945	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
GFS31_RS04945	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GFS31_RS04950	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GFS31_RS04955	COG0574	Belongs to the PEP-utilizing enzyme family
GFS31_RS04955	COG3848	Pyruvate phosphate dikinase
GFS31_RS04960	COG0415	Belongs to the DNA photolyase family
GFS31_RS04965	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GFS31_RS04990	COG1192	Involved in chromosome partitioning
GFS31_RS05000	COG0275	rRNA processing
GFS31_RS05005	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GFS31_RS05040	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
GFS31_RS05055	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GFS31_RS05060	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GFS31_RS05075	COG3845	ABC transporter
GFS31_RS05080	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GFS31_RS05085	COG0776	regulation of translation
GFS31_RS05100	COG1741	Belongs to the pirin family
GFS31_RS05110	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GFS31_RS05145	COG2890	protein-(glutamine-N5) methyltransferase activity
GFS31_RS05160	COG0772	Belongs to the SEDS family
GFS31_RS05170	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GFS31_RS05175	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GFS31_RS05180	COG0719	Fe-S assembly protein
GFS31_RS05185	COG0396	ATPase activity
GFS31_RS05190	COG0719	Fe-S assembly protein
GFS31_RS05195	COG4802	Ferredoxin thioredoxin reductase catalytic beta chain
GFS31_RS05215	COG0587	DNA-directed DNA polymerase activity
GFS31_RS05225	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GFS31_RS05240	COG1012	belongs to the aldehyde dehydrogenase family
GFS31_RS05250	COG0564	pseudouridine synthase activity
GFS31_RS05280	COG2205	protein histidine kinase activity
GFS31_RS05280	COG0784	Response regulator, receiver
GFS31_RS05285	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
GFS31_RS05305	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GFS31_RS05320	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GFS31_RS05330	COG0330	HflC and HflK could
GFS31_RS05370	COG1218	3'(2'),5'-bisphosphate nucleotidase
GFS31_RS05395	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GFS31_RS05400	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GFS31_RS05425	COG0842	Transport permease protein
GFS31_RS05435	COG0589	response to stress
GFS31_RS05440	COG0589	response to stress
GFS31_RS05450	COG5433	transposase activity
GFS31_RS05460	COG1070	Carbohydrate kinase
GFS31_RS05470	COG0174	glutamine synthetase
GFS31_RS05475	COG1192	Involved in chromosome partitioning
GFS31_RS05505	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GFS31_RS05510	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GFS31_RS05520	COG0180	Tryptophanyl-tRNA synthetase
GFS31_RS05545	COG0237	dephospho-CoA kinase activity
GFS31_RS05545	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GFS31_RS05550	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GFS31_RS05560	COG0356	it plays a direct role in the translocation of protons across the membrane
GFS31_RS05565	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GFS31_RS05570	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GFS31_RS05575	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GFS31_RS05580	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GFS31_RS05585	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GFS31_RS05590	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GFS31_RS05600	COG1671	Belongs to the UPF0178 family
GFS31_RS05610	COG0752	glycyl-tRNA synthetase alpha subunit
GFS31_RS05615	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
GFS31_RS05620	COG1361	Conserved repeat domain
GFS31_RS05635	COG0243	molybdopterin cofactor binding
GFS31_RS05640	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GFS31_RS05680	COG0446	pyridine nucleotide-disulphide oxidoreductase
GFS31_RS05690	COG0723	plastoquinol--plastocyanin reductase activity
GFS31_RS05720	COG1420	regulation of RNA biosynthetic process
GFS31_RS05725	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GFS31_RS05740	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GFS31_RS05765	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GFS31_RS05780	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GFS31_RS05785	COG1850	ribulose-bisphosphate carboxylase activity
GFS31_RS05795	COG4451	ribulose bisphosphate carboxylase, small
GFS31_RS05805	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
GFS31_RS05810	COG1116	anion transmembrane transporter activity
GFS31_RS05815	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GFS31_RS05820	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GFS31_RS05855	COG0509	glycine decarboxylation via glycine cleavage system
GFS31_RS05870	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GFS31_RS05875	COG0443	Heat shock 70 kDa protein
GFS31_RS05885	COG0259	pyridoxamine-phosphate oxidase activity
GFS31_RS05895	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GFS31_RS05905	COG0702	epimerase
GFS31_RS05925	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GFS31_RS05935	COG1047	Peptidyl-prolyl cis-trans
GFS31_RS05945	COG0408	coproporphyrinogen oxidase activity
GFS31_RS05955	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GFS31_RS05955	COG0519	Catalyzes the synthesis of GMP from XMP
GFS31_RS05960	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
GFS31_RS05970	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
GFS31_RS05975	COG0424	maF-like protein
GFS31_RS05985	COG2264	protein methyltransferase activity
GFS31_RS06000	COG1252	NADH dehydrogenase
GFS31_RS06050	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
GFS31_RS06055	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GFS31_RS06060	COG0251	oxidation-reduction process
GFS31_RS06070	COG1640	4-alpha-glucanotransferase
GFS31_RS06080	COG0792	nuclease activity
GFS31_RS06090	COG0300	oxidoreductase activity
GFS31_RS06090	COG3000	fatty acid hydroxylase
GFS31_RS06110	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
GFS31_RS06115	COG2211	Major facilitator Superfamily
GFS31_RS06125	COG0678	peroxiredoxin activity
GFS31_RS06180	COG2346	COG2346, Truncated hemoglobins
GFS31_RS06190	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GFS31_RS06200	COG5001	Diguanylate cyclase
GFS31_RS06220	COG1187	pseudouridine synthase activity
GFS31_RS06260	COG0631	protein serine/threonine phosphatase activity
GFS31_RS06285	COG0705	Rhomboid family
GFS31_RS06290	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
GFS31_RS06305	COG0670	Belongs to the BI1 family
GFS31_RS06320	COG0028	Belongs to the TPP enzyme family
GFS31_RS06340	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GFS31_RS06355	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
GFS31_RS06360	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GFS31_RS06375	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GFS31_RS06385	COG0629	single-stranded DNA binding
GFS31_RS06390	COG1077	Cell shape determining protein MreB Mrl
GFS31_RS06425	COG0748	coenzyme F420 binding
GFS31_RS06435	COG1177	transmembrane transport
GFS31_RS06440	COG1176	ABC-type spermidine putrescine transport system, permease component I
GFS31_RS06450	COG3842	ATPase activity
GFS31_RS06455	COG0515	serine threonine protein kinase
GFS31_RS06455	COG3266	domain, Protein
GFS31_RS06465	COG1051	belongs to the nudix hydrolase family
GFS31_RS06470	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GFS31_RS06475	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
GFS31_RS06485	COG0284	orotidine-5'-phosphate decarboxylase activity
GFS31_RS06490	COG0511	ligase activity, forming carbon-carbon bonds
GFS31_RS06495	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GFS31_RS06500	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GFS31_RS06505	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
GFS31_RS06515	COG0484	heat shock protein binding
GFS31_RS06525	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GFS31_RS06535	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
GFS31_RS06545	COG1007	ATP synthesis coupled electron transport
GFS31_RS06550	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GFS31_RS06555	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GFS31_RS06585	COG1196	nuclear chromosome segregation
GFS31_RS06595	COG0515	serine threonine protein kinase
GFS31_RS06595	COG4991	sh3 domain protein
GFS31_RS06595	COG3064	Membrane
GFS31_RS06600	COG4251	negative regulation of phosphorylation
GFS31_RS06600	COG2203	Gaf domain
GFS31_RS06600	COG5001	Diguanylate cyclase
GFS31_RS06600	COG3706	GGDEF domain
GFS31_RS06620	COG0559	Belongs to the binding-protein-dependent transport system permease family
GFS31_RS06625	COG1191	sigma factor activity
GFS31_RS06630	COG0546	phosphoglycolate phosphatase activity
GFS31_RS06640	COG0529	Catalyzes the synthesis of activated sulfate
GFS31_RS06645	COG1802	Transcriptional regulator
GFS31_RS06650	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GFS31_RS06660	COG0588	phosphoglycerate mutase activity
GFS31_RS06665	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GFS31_RS06675	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GFS31_RS06680	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GFS31_RS06690	COG1981	membrane
GFS31_RS06695	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GFS31_RS06705	COG0857	belongs to the CobB CobQ family
GFS31_RS06715	COG1215	transferase activity, transferring glycosyl groups
GFS31_RS06725	COG0346	lactoylglutathione lyase activity
GFS31_RS06730	COG0456	acetyltransferase
GFS31_RS06745	COG1666	GTP binding
GFS31_RS06785	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GFS31_RS06790	COG0581	inorganic phosphate transmembrane transporter activity
GFS31_RS06795	COG0573	inorganic phosphate transmembrane transporter activity
GFS31_RS06800	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GFS31_RS06805	COG2203	Gaf domain
GFS31_RS06805	COG2199	diguanylate cyclase activity
GFS31_RS06810	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GFS31_RS06815	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
GFS31_RS06820	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GFS31_RS06825	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GFS31_RS06830	COG0357	Ribosomal RNA small subunit methyltransferase G
GFS31_RS06835	COG1122	ATPase activity
GFS31_RS06850	COG0644	oxidoreductase
GFS31_RS06880	COG1316	TRANSCRIPTIONal
GFS31_RS06905	COG0442	prolyl-tRNA aminoacylation
GFS31_RS06915	COG0131	Imidazoleglycerol-phosphate dehydratase
GFS31_RS06920	COG4251	negative regulation of phosphorylation
GFS31_RS06955	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GFS31_RS06970	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GFS31_RS06980	COG2843	Capsule synthesis protein
GFS31_RS07000	COG0798	PFAM Bile acid sodium symporter
GFS31_RS07005	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GFS31_RS07010	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
GFS31_RS07055	COG1672	PFAM Archaeal ATPase
GFS31_RS07060	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GFS31_RS07060	COG0426	domain, Protein
GFS31_RS07075	COG0658	competence protein
GFS31_RS07075	COG2333	competence protein COMEC
GFS31_RS07085	COG0515	serine threonine protein kinase
GFS31_RS07085	COG1357	PFAM Pentapeptide repeats (8 copies)
GFS31_RS07090	COG0483	inositol monophosphate 1-phosphatase activity
GFS31_RS07110	COG0439	Biotin carboxylase
GFS31_RS07120	COG0154	amidase activity
GFS31_RS07130	COG1543	Belongs to the glycosyl hydrolase 57 family
GFS31_RS07140	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GFS31_RS07145	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GFS31_RS07155	COG0572	uridine kinase
GFS31_RS07160	COG1366	Belongs to the anti-sigma-factor antagonist family
GFS31_RS07175	COG0446	pyridine nucleotide-disulphide oxidoreductase
GFS31_RS07190	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GFS31_RS07205	COG0617	tRNA 3'-terminal CCA addition
GFS31_RS07215	COG1233	COG1233 Phytoene dehydrogenase and related
GFS31_RS07235	COG0018	arginyl-trna synthetase
GFS31_RS07240	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GFS31_RS07255	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
GFS31_RS07285	COG2203	Gaf domain
GFS31_RS07285	COG3706	GGDEF domain
GFS31_RS07285	COG4251	negative regulation of phosphorylation
GFS31_RS07285	COG5001	Diguanylate cyclase
GFS31_RS07290	COG2201	protein-glutamate methylesterase activity
GFS31_RS07305	COG0840	transmembrane signaling receptor activity
GFS31_RS07305	COG5278	phosphoserine phosphatase activity
GFS31_RS07310	COG5278	phosphoserine phosphatase activity
GFS31_RS07310	COG0840	transmembrane signaling receptor activity
GFS31_RS07315	COG0835	chemotaxis
GFS31_RS07330	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GFS31_RS07345	COG3706	GGDEF domain
GFS31_RS07345	COG2203	Gaf domain
GFS31_RS07345	COG5001	Diguanylate cyclase
GFS31_RS07345	COG4251	negative regulation of phosphorylation
GFS31_RS07355	COG0716	FMN binding
GFS31_RS07360	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
GFS31_RS07365	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GFS31_RS07375	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GFS31_RS07375	COG0072	phenylalanine-tRNA ligase activity
GFS31_RS07380	COG1397	ADP-ribosylglycohydrolase
GFS31_RS07390	COG0583	DNA-binding transcription factor activity
GFS31_RS07400	COG0165	Argininosuccinate lyase
GFS31_RS07405	COG0463	Glycosyl transferase, family 2
GFS31_RS07405	COG0457	Tetratricopeptide repeat
GFS31_RS07445	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GFS31_RS07465	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GFS31_RS07495	COG1074	ATP-dependent DNA helicase activity
GFS31_RS07500	COG0436	Aminotransferase
GFS31_RS07510	COG1842	Phage shock protein A
GFS31_RS07540	COG1570	exodeoxyribonuclease VII activity
GFS31_RS07545	COG2177	Part of the ABC transporter FtsEX involved in
GFS31_RS07565	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
GFS31_RS07570	COG0113	porphobilinogen synthase activity
GFS31_RS07585	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GFS31_RS07585	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GFS31_RS07595	COG0616	signal peptide processing
GFS31_RS07600	COG0697	spore germination
GFS31_RS07620	COG1233	COG1233 Phytoene dehydrogenase and related
GFS31_RS07635	COG0514	ATP-dependent DNA helicase (RecQ)
GFS31_RS07645	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GFS31_RS07655	COG2205	protein histidine kinase activity
GFS31_RS07655	COG2202	Pas domain
GFS31_RS07665	COG2205	protein histidine kinase activity
GFS31_RS07690	COG2197	response regulator
GFS31_RS07730	COG0006	proline dipeptidase activity
GFS31_RS07735	COG0745	RESPONSE REGULATOR receiver
GFS31_RS07740	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GFS31_RS07755	COG2205	protein histidine kinase activity
GFS31_RS07780	COG0488	(ABC) transporter
GFS31_RS07785	COG0330	HflC and HflK could
GFS31_RS07800	COG0644	oxidoreductase
GFS31_RS07805	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GFS31_RS07810	COG0513	Belongs to the DEAD box helicase family
GFS31_RS07820	COG4636	protein conserved in cyanobacteria
GFS31_RS07905	COG2205	protein histidine kinase activity
GFS31_RS07905	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GFS31_RS07910	COG0628	permease
GFS31_RS07930	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GFS31_RS07945	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GFS31_RS07955	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GFS31_RS07960	COG0612	Peptidase, M16
GFS31_RS07965	COG0612	Peptidase, M16
GFS31_RS07970	COG0765	amino acid transport
GFS31_RS07975	COG1126	abc transporter atp-binding protein
GFS31_RS08010	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GFS31_RS08015	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GFS31_RS08020	COG0095	Lipoate-protein ligase
GFS31_RS08025	COG2385	sporulation resulting in formation of a cellular spore
GFS31_RS08055	COG4243	Vitamin k epoxide reductase
GFS31_RS08085	COG0159	tryptophan synthase activity
GFS31_RS08095	COG0745	RESPONSE REGULATOR receiver
GFS31_RS08100	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
GFS31_RS08105	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GFS31_RS08135	COG1045	serine acetyltransferase
GFS31_RS08160	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
GFS31_RS08170	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GFS31_RS08175	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
GFS31_RS08180	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
GFS31_RS08185	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GFS31_RS08190	COG0793	Belongs to the peptidase S41A family
GFS31_RS08195	COG1505	serine-type exopeptidase activity
GFS31_RS08200	COG1994	Peptidase M50
GFS31_RS08200	COG0517	IMP dehydrogenase activity
GFS31_RS08215	COG1619	proteins homologs of microcin C7 resistance protein MccF
GFS31_RS08220	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GFS31_RS08225	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GFS31_RS08235	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
GFS31_RS08240	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GFS31_RS08255	COG2361	Protein of unknown function DUF86
GFS31_RS08280	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GFS31_RS08285	COG1175	transmembrane transport
GFS31_RS08290	COG0419	ATPase involved in DNA repair
GFS31_RS08300	COG0436	Aminotransferase
GFS31_RS08310	COG2843	Capsule synthesis protein
GFS31_RS08315	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GFS31_RS08325	COG1132	(ABC) transporter
GFS31_RS08350	COG0025	NhaP-type Na H and K H
GFS31_RS08355	COG0058	SHG alpha-glucan phosphorylase activity
GFS31_RS08370	COG3063	Type IV pilus biogenesis stability protein PilW
GFS31_RS08385	COG1404	Belongs to the peptidase S8 family
GFS31_RS08400	COG0440	acetolactate synthase activity
GFS31_RS08405	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GFS31_RS08435	COG1357	PFAM Pentapeptide repeats (8 copies)
GFS31_RS08435	COG0515	serine threonine protein kinase
GFS31_RS08440	COG0673	inositol 2-dehydrogenase activity
GFS31_RS08470	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GFS31_RS08475	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
GFS31_RS08495	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
GFS31_RS08510	COG0297	glycogen (starch) synthase activity
GFS31_RS08520	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GFS31_RS08535	COG0616	signal peptide processing
GFS31_RS08550	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GFS31_RS08555	COG0025	NhaP-type Na H and K H
GFS31_RS08560	COG1404	Belongs to the peptidase S8 family
GFS31_RS08565	COG4249	Peptidase C14 caspase catalytic subunit p20
GFS31_RS08565	COG2319	Wd-40 repeat
GFS31_RS08570	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GFS31_RS08595	COG2205	protein histidine kinase activity
GFS31_RS08595	COG2202	Pas domain
GFS31_RS08630	COG3657	addiction module killer protein
GFS31_RS08680	COG0473	3-isopropylmalate dehydrogenase activity
GFS31_RS08685	COG0811	peptide transport
GFS31_RS08695	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
GFS31_RS08730	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GFS31_RS08735	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
GFS31_RS08750	COG0204	Acyl-transferase
GFS31_RS08750	COG0318	PFAM AMP-dependent synthetase and ligase
GFS31_RS08755	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GFS31_RS08765	COG0459	protein refolding
GFS31_RS08770	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GFS31_RS08775	COG0123	including yeast histone deacetylase and acetoin utilization protein
GFS31_RS08785	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
GFS31_RS08800	COG0788	formyltetrahydrofolate deformylase activity
GFS31_RS08810	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GFS31_RS08815	COG3977	Valine--pyruvate aminotransferase
GFS31_RS08835	COG2081	HI0933 family
GFS31_RS08885	COG0151	Belongs to the GarS family
GFS31_RS08895	COG1357	PFAM Pentapeptide repeats (8 copies)
GFS31_RS08900	COG0504	CTP synthase activity
GFS31_RS08920	COG0438	transferase activity, transferring glycosyl groups
GFS31_RS08930	COG1381	Involved in DNA repair and RecF pathway recombination
GFS31_RS08940	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GFS31_RS08945	COG2203	Gaf domain
GFS31_RS08945	COG3706	GGDEF domain
GFS31_RS08945	COG4251	negative regulation of phosphorylation
GFS31_RS08945	COG5001	Diguanylate cyclase
GFS31_RS08965	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GFS31_RS09010	COG0742	ribosomal rna small subunit methyltransferase
GFS31_RS09015	COG2205	protein histidine kinase activity
GFS31_RS09015	COG5002	protein histidine kinase activity
GFS31_RS09015	COG0784	Response regulator, receiver
GFS31_RS09020	COG2201	protein-glutamate methylesterase activity
GFS31_RS09025	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GFS31_RS09035	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GFS31_RS09050	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GFS31_RS09085	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GFS31_RS09090	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
GFS31_RS09100	COG2003	Belongs to the UPF0758 family
GFS31_RS09120	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GFS31_RS09135	COG3769	mannosylglycerate metabolic process
GFS31_RS09140	COG1160	GTP binding
GFS31_RS09150	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GFS31_RS09150	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GFS31_RS09165	COG2046	Belongs to the sulfate adenylyltransferase family
GFS31_RS09170	COG0751	glycine-tRNA ligase activity
GFS31_RS09175	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GFS31_RS09200	COG2319	Wd-40 repeat
GFS31_RS09200	COG3903	Transcriptional regulator
GFS31_RS09205	COG1104	cysteine desulfurase activity
GFS31_RS09210	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GFS31_RS09225	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GFS31_RS09235	COG0195	Participates in both transcription termination and antitermination
GFS31_RS09240	COG0779	Required for maturation of 30S ribosomal subunits
GFS31_RS09250	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GFS31_RS09255	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
GFS31_RS09260	COG0019	diaminopimelate decarboxylase activity
GFS31_RS09265	COG0456	acetyltransferase
GFS31_RS09270	COG0542	response to heat
GFS31_RS09275	COG0745	RESPONSE REGULATOR receiver
GFS31_RS09300	COG0233	cytoplasmic translational termination
GFS31_RS09305	COG0528	UMP kinase activity
GFS31_RS09310	COG0363	glucosamine-6-phosphate deaminase activity
GFS31_RS09325	COG0668	transmembrane transport
GFS31_RS09335	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GFS31_RS09400	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GFS31_RS09405	COG0483	inositol monophosphate 1-phosphatase activity
GFS31_RS09415	COG1489	DNA binding
GFS31_RS09495	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GFS31_RS09500	COG1126	abc transporter atp-binding protein
GFS31_RS09505	COG0765	amino acid transport
GFS31_RS09510	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GFS31_RS09520	COG1131	(ABC) transporter
GFS31_RS09535	COG1797	cobyrinic acid a,c-diamide synthase activity
GFS31_RS09545	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GFS31_RS09570	COG0527	aspartate kinase activity
GFS31_RS09575	COG0589	response to stress
GFS31_RS09580	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GFS31_RS09585	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GFS31_RS09590	COG1116	anion transmembrane transporter activity
GFS31_RS09590	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GFS31_RS09595	COG1116	anion transmembrane transporter activity
GFS31_RS09620	COG3654	unkown
GFS31_RS09640	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
GFS31_RS09665	COG0483	inositol monophosphate 1-phosphatase activity
GFS31_RS09670	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GFS31_RS09685	COG2226	methyltransferase
GFS31_RS09695	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GFS31_RS09700	COG0629	single-stranded DNA binding
GFS31_RS09710	COG2166	iron-sulfur cluster assembly
GFS31_RS09715	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GFS31_RS09720	COG0784	Response regulator, receiver
GFS31_RS09720	COG5002	protein histidine kinase activity
GFS31_RS09745	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GFS31_RS09750	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
GFS31_RS09760	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GFS31_RS09785	COG0339	signal peptide processing
GFS31_RS09790	COG2226	methyltransferase
GFS31_RS09800	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
GFS31_RS09825	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
GFS31_RS09830	COG4251	negative regulation of phosphorylation
GFS31_RS09840	COG2205	protein histidine kinase activity
GFS31_RS09840	COG5002	protein histidine kinase activity
GFS31_RS09840	COG0784	Response regulator, receiver
GFS31_RS09860	COG0166	Belongs to the GPI family
GFS31_RS09865	COG0709	Synthesizes selenophosphate from selenide and ATP
GFS31_RS09870	COG0805	protein transport
GFS31_RS09880	COG0826	peptidase U32
GFS31_RS09890	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
GFS31_RS09940	COG1162	GTPase activity
GFS31_RS09950	COG0484	heat shock protein binding
GFS31_RS09955	COG0443	Heat shock 70 kDa protein
GFS31_RS09960	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GFS31_RS09965	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GFS31_RS09975	COG1459	type II secretion system
GFS31_RS09980	COG0640	Transcriptional regulator
GFS31_RS10005	COG0484	heat shock protein binding
GFS31_RS10015	COG0454	-acetyltransferase
GFS31_RS10035	COG1214	PFAM Peptidase M22, glycoprotease
GFS31_RS10040	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GFS31_RS10045	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GFS31_RS10055	COG1695	Transcriptional regulator
GFS31_RS10060	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GFS31_RS10065	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GFS31_RS10070	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GFS31_RS10075	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GFS31_RS10105	COG0697	spore germination
GFS31_RS10130	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GFS31_RS10140	COG0167	dihydroorotate dehydrogenase activity
GFS31_RS10150	COG0830	nickel cation binding
GFS31_RS10155	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
GFS31_RS10175	COG0745	RESPONSE REGULATOR receiver
GFS31_RS10195	COG3266	domain, Protein
GFS31_RS10195	COG0515	serine threonine protein kinase
GFS31_RS10200	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GFS31_RS10210	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GFS31_RS10215	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GFS31_RS10235	COG1136	(ABC) transporter
GFS31_RS10235	COG0577	efflux transmembrane transporter activity
GFS31_RS10245	COG1136	(ABC) transporter
GFS31_RS10245	COG0577	efflux transmembrane transporter activity
GFS31_RS10255	COG3659	wide pore channel activity
GFS31_RS10265	COG2133	pyrroloquinoline quinone binding
GFS31_RS10270	COG0303	'Molybdopterin
GFS31_RS10280	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GFS31_RS10295	COG1615	UPF0182 protein
GFS31_RS10300	COG0515	serine threonine protein kinase
GFS31_RS10300	COG1357	PFAM Pentapeptide repeats (8 copies)
GFS31_RS10305	COG5002	protein histidine kinase activity
GFS31_RS10310	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GFS31_RS10315	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
GFS31_RS10325	COG0438	transferase activity, transferring glycosyl groups
GFS31_RS10340	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GFS31_RS10360	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
GFS31_RS10365	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
GFS31_RS10370	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GFS31_RS10375	COG1494	fructose-1,6-bisphosphatase
GFS31_RS10380	COG1309	transcriptional regulator
GFS31_RS10390	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
GFS31_RS10395	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GFS31_RS10400	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
GFS31_RS10405	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GFS31_RS10420	COG1132	(ABC) transporter
GFS31_RS10435	COG1620	l-lactate permease
GFS31_RS10450	COG2095	MarC family integral membrane protein
GFS31_RS10460	COG0175	sulfate reduction
GFS31_RS10495	COG0371	Dehydrogenase
GFS31_RS10500	COG0436	Aminotransferase
GFS31_RS10505	COG0017	Asparaginyl-tRNA synthetase
GFS31_RS10510	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
GFS31_RS10540	COG0297	glycogen (starch) synthase activity
GFS31_RS10545	COG0824	Thioesterase
GFS31_RS10550	COG5001	Diguanylate cyclase
GFS31_RS10550	COG5002	protein histidine kinase activity
GFS31_RS10560	COG0493	'glutamate synthase
GFS31_RS10570	COG0463	Glycosyl transferase, family 2
GFS31_RS10575	COG0194	GDP metabolic process
GFS31_RS10585	COG0628	permease
GFS31_RS10595	COG1032	radical SAM domain protein
GFS31_RS10600	COG1181	Belongs to the D-alanine--D-alanine ligase family
GFS31_RS10630	COG4208	sulfate ABC transporter
GFS31_RS10635	COG1176	ABC-type spermidine putrescine transport system, permease component I
GFS31_RS10665	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
GFS31_RS10675	COG0730	response to heat
GFS31_RS10690	COG0412	Dienelactone hydrolase
GFS31_RS10695	COG0515	serine threonine protein kinase
GFS31_RS10695	COG1357	PFAM Pentapeptide repeats (8 copies)
GFS31_RS10735	COG3409	Peptidoglycan-binding domain 1 protein
GFS31_RS10735	COG3429	Glucose-6-phosphate dehydrogenase subunit
GFS31_RS10740	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GFS31_RS10745	COG0789	Transcriptional regulator
GFS31_RS10755	COG0456	acetyltransferase
GFS31_RS10760	COG0121	glutamine amidotransferase
GFS31_RS10765	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
GFS31_RS10775	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GFS31_RS10775	COG4451	ribulose bisphosphate carboxylase, small
GFS31_RS10780	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
GFS31_RS10785	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
GFS31_RS10790	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
GFS31_RS10795	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GFS31_RS10800	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GFS31_RS10815	COG0163	prenyltransferase activity
GFS31_RS10820	COG0557	exoribonuclease II activity
GFS31_RS10825	COG0704	Plays a role in the regulation of phosphate uptake
GFS31_RS10835	COG0469	pyruvate kinase activity
GFS31_RS10845	COG3264	Mechanosensitive ion channel
GFS31_RS10845	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
GFS31_RS10865	COG2183	response to ionizing radiation
GFS31_RS10870	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GFS31_RS10875	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GFS31_RS10880	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GFS31_RS10890	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GFS31_RS10890	COG0519	Catalyzes the synthesis of GMP from XMP
GFS31_RS10895	COG4251	negative regulation of phosphorylation
GFS31_RS10895	COG5001	Diguanylate cyclase
GFS31_RS10895	COG2203	Gaf domain
GFS31_RS10895	COG3706	GGDEF domain
GFS31_RS10910	COG0459	protein refolding
GFS31_RS10915	COG0598	Magnesium transport protein CorA
GFS31_RS10920	COG1131	(ABC) transporter
GFS31_RS10925	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
GFS31_RS10935	COG0105	UTP biosynthetic process
GFS31_RS10940	COG1982	Orn Lys Arg decarboxylase major
GFS31_RS10955	COG5002	protein histidine kinase activity
GFS31_RS11015	COG0481	GTPase activity
GFS31_RS11030	COG0514	ATP-dependent DNA helicase (RecQ)
GFS31_RS11035	COG0557	exoribonuclease II activity
GFS31_RS11040	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GFS31_RS11045	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GFS31_RS11050	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GFS31_RS11060	COG1178	ABC-type Fe3 transport system permease component
GFS31_RS11070	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GFS31_RS11080	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GFS31_RS11085	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GFS31_RS11090	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GFS31_RS11095	COG5001	Diguanylate cyclase
GFS31_RS11100	COG2205	protein histidine kinase activity
GFS31_RS11100	COG0784	Response regulator, receiver
GFS31_RS11110	COG1573	uracil-dna glycosylase
GFS31_RS11135	COG1509	lysine 2,3-aminomutase activity
GFS31_RS11140	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
GFS31_RS11145	COG0037	tRNA processing
GFS31_RS11160	COG2884	Cell division ATP-binding protein ftsE
GFS31_RS11165	COG0739	heme binding
GFS31_RS11170	COG0741	lytic transglycosylase activity
GFS31_RS11190	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GFS31_RS11195	COG5398	heme oxygenase
GFS31_RS11200	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
GFS31_RS11210	COG0686	Belongs to the AlaDH PNT family
GFS31_RS11215	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GFS31_RS11220	COG0745	RESPONSE REGULATOR receiver
GFS31_RS11230	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GFS31_RS11240	COG0701	Predicted permease
GFS31_RS11260	COG1596	polysaccharide export
GFS31_RS11305	COG1733	regulation of RNA biosynthetic process
GFS31_RS11310	COG0445	tRNA wobble uridine modification
GFS31_RS11330	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GFS31_RS11350	COG0571	ribonuclease III activity
GFS31_RS11365	COG1357	PFAM Pentapeptide repeats (8 copies)
GFS31_RS11365	COG0515	serine threonine protein kinase
GFS31_RS11390	COG0640	Transcriptional regulator
GFS31_RS11405	COG5001	Diguanylate cyclase
GFS31_RS11410	COG0784	Response regulator, receiver
GFS31_RS11410	COG5002	protein histidine kinase activity
GFS31_RS11490	COG0582	viral genome integration into host DNA
GFS31_RS11505	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GFS31_RS11510	COG0831	urea catabolic process
GFS31_RS11520	COG0832	Belongs to the urease beta subunit family
GFS31_RS11540	COG0134	indole-3-glycerol-phosphate synthase activity
GFS31_RS11545	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GFS31_RS11550	COG4636	protein conserved in cyanobacteria
GFS31_RS11565	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GFS31_RS11575	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GFS31_RS11580	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GFS31_RS11610	COG1187	pseudouridine synthase activity
GFS31_RS11615	COG5002	protein histidine kinase activity
GFS31_RS11625	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GFS31_RS11640	COG5002	protein histidine kinase activity
GFS31_RS11650	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GFS31_RS11670	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GFS31_RS11695	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GFS31_RS11705	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
GFS31_RS11715	COG0426	domain, Protein
GFS31_RS11715	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GFS31_RS11720	COG0720	synthase
GFS31_RS11750	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GFS31_RS11765	COG1104	cysteine desulfurase activity
GFS31_RS11770	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
GFS31_RS11775	COG0069	glutamate synthase activity
GFS31_RS11775	COG0070	glutamate synthase
GFS31_RS11775	COG0067	glutamate synthase
GFS31_RS11795	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GFS31_RS11800	COG2911	Protein conserved in bacteria
GFS31_RS11800	COG3266	domain, Protein
GFS31_RS11800	COG1361	Conserved repeat domain
GFS31_RS11825	COG0039	L-malate dehydrogenase activity
GFS31_RS11830	COG0402	S-adenosylhomocysteine deaminase activity
GFS31_RS11835	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GFS31_RS11840	COG0010	Belongs to the arginase family
GFS31_RS11845	COG0375	protein maturation
GFS31_RS11850	COG0215	cysteine-tRNA ligase activity
GFS31_RS11855	COG0135	phosphoribosylanthranilate isomerase activity
GFS31_RS11865	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
GFS31_RS11895	COG1704	LemA family
GFS31_RS11900	COG0501	Belongs to the peptidase M48B family
GFS31_RS11905	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
GFS31_RS11910	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GFS31_RS11925	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GFS31_RS11960	COG3012	SEC-C Motif Domain Protein
GFS31_RS11975	COG0733	neurotransmitter:sodium symporter activity
GFS31_RS11980	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
GFS31_RS12010	COG4067	protein conserved in archaea
GFS31_RS12010	COG0189	ligase activity
GFS31_RS12015	COG0189	ligase activity
GFS31_RS12055	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GFS31_RS12075	COG2205	protein histidine kinase activity
GFS31_RS12075	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GFS31_RS12080	COG3437	response regulator, receiver
GFS31_RS12090	COG0784	Response regulator, receiver
GFS31_RS12090	COG2205	protein histidine kinase activity
GFS31_RS12095	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GFS31_RS12100	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GFS31_RS12105	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GFS31_RS12110	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
GFS31_RS12155	COG5398	heme oxygenase
GFS31_RS12170	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
GFS31_RS12200	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GFS31_RS12205	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GFS31_RS12210	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GFS31_RS12210	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GFS31_RS12215	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GFS31_RS12240	COG0575	Belongs to the CDS family
GFS31_RS12255	COG0494	nUDIX hydrolase
GFS31_RS12260	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GFS31_RS12265	COG4221	oxidoreductase activity
GFS31_RS12280	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GFS31_RS12290	COG0577	efflux transmembrane transporter activity
GFS31_RS12290	COG1136	(ABC) transporter
GFS31_RS12300	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GFS31_RS12310	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GFS31_RS12310	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GFS31_RS12315	COG3118	belongs to the thioredoxin family
GFS31_RS12325	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GFS31_RS12330	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GFS31_RS12335	COG0085	RNA polymerase activity
GFS31_RS12340	COG0084	hydrolase, TatD family'
GFS31_RS12345	COG0268	Binds directly to 16S ribosomal RNA
GFS31_RS12350	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GFS31_RS12355	COG0589	response to stress
GFS31_RS12360	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
GFS31_RS12360	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GFS31_RS12365	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GFS31_RS12415	COG0489	protein tyrosine kinase activity
GFS31_RS12425	COG1597	lipid kinase activity
GFS31_RS12425	COG1803	Methylglyoxal synthase
GFS31_RS12430	COG0312	modulator of DNA gyrase
GFS31_RS12445	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GFS31_RS12500	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GFS31_RS12525	COG2326	polyphosphate kinase activity
GFS31_RS12535	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GFS31_RS12540	COG0393	Putative heavy-metal-binding
GFS31_RS12545	COG0393	Putative heavy-metal-binding
GFS31_RS12560	COG0556	nucleotide-excision repair
GFS31_RS12565	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GFS31_RS12595	COG2319	Wd-40 repeat
GFS31_RS12595	COG1672	PFAM Archaeal ATPase
GFS31_RS12615	COG0745	RESPONSE REGULATOR receiver
GFS31_RS12620	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GFS31_RS12625	COG0848	biopolymer transport protein
GFS31_RS12640	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GFS31_RS12645	COG5002	protein histidine kinase activity
GFS31_RS12650	COG2308	Evidence 4 Homologs of previously reported genes of
GFS31_RS12655	COG0730	response to heat
GFS31_RS12660	COG0384	phenazine biosynthesis protein PhzF
GFS31_RS12665	COG2052	Domain of unknown function (DUF370)
GFS31_RS12670	COG1293	RNA-binding protein homologous to eukaryotic snRNP
GFS31_RS12705	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GFS31_RS12710	COG0717	Belongs to the dCTP deaminase family
GFS31_RS12720	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
GFS31_RS12725	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GFS31_RS12730	COG1090	epimerase
GFS31_RS12740	COG1473	amidohydrolase
GFS31_RS12785	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
GFS31_RS12790	COG0271	Belongs to the BolA IbaG family
GFS31_RS12800	COG1404	Belongs to the peptidase S8 family
GFS31_RS12800	COG4935	Belongs to the peptidase S8 family
GFS31_RS12815	COG0521	Mo-molybdopterin cofactor biosynthetic process
GFS31_RS12845	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
GFS31_RS12855	COG1054	Belongs to the UPF0176 family
GFS31_RS12860	COG0848	biopolymer transport protein
GFS31_RS12870	COG0802	atpase or kinase
GFS31_RS12875	COG1653	transport
GFS31_RS12890	COG3842	ATPase activity
GFS31_RS12915	COG1231	oxidoreductase activity
GFS31_RS12935	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GFS31_RS12940	COG0398	Pfam SNARE associated Golgi protein
GFS31_RS12960	COG0217	transcriptional regulatory protein
GFS31_RS12985	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
GFS31_RS12995	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GFS31_RS13000	COG0768	penicillin binding
GFS31_RS13050	COG0275	rRNA processing
GFS31_RS13060	COG0297	glycogen (starch) synthase activity
GFS31_RS13065	COG1215	transferase activity, transferring glycosyl groups
GFS31_RS13070	COG0463	Glycosyl transferase, family 2
GFS31_RS13080	COG0438	transferase activity, transferring glycosyl groups
GFS31_RS13100	COG0640	Transcriptional regulator
GFS31_RS13105	COG0170	dolichyl monophosphate biosynthetic process
GFS31_RS13115	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GFS31_RS13125	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
GFS31_RS13165	COG2197	response regulator
GFS31_RS13170	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
GFS31_RS13175	COG4783	chaperone-mediated protein folding
GFS31_RS13185	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GFS31_RS13195	COG1131	(ABC) transporter
GFS31_RS13200	COG2066	Belongs to the glutaminase family
GFS31_RS13215	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GFS31_RS13235	COG1653	transport
GFS31_RS13240	COG3842	ATPase activity
GFS31_RS13245	COG0395	ABC-type sugar transport system, permease component
GFS31_RS13250	COG1175	transmembrane transport
GFS31_RS13260	COG0109	protoheme IX farnesyltransferase activity
GFS31_RS13275	COG3937	granule-associated protein
GFS31_RS13280	COG0335	large ribosomal subunit rRNA binding
GFS31_RS13290	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GFS31_RS13295	COG0250	Participates in transcription elongation, termination and antitermination
GFS31_RS13300	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GFS31_RS13305	COG0081	regulation of translation
GFS31_RS13310	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GFS31_RS13315	COG0222	ribosome binding
GFS31_RS13325	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
GFS31_RS13340	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
GFS31_RS13350	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GFS31_RS13365	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
GFS31_RS13370	COG4106	trans-aconitate 2-methyltransferase activity
GFS31_RS13390	COG1492	cobalamin metabolic process
GFS31_RS13410	COG0321	lipoyl(octanoyl) transferase activity
GFS31_RS13415	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GFS31_RS13420	COG0653	protein targeting
GFS31_RS13440	COG1970	mechanosensitive ion channel activity
GFS31_RS13450	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GFS31_RS13455	COG0133	tryptophan synthase activity
GFS31_RS13465	COG0003	Pfam Anion-transporting ATPase
GFS31_RS13470	COG2814	Major facilitator Superfamily
GFS31_RS13500	COG2273	Hydrolase Family 16
GFS31_RS13500	COG5297	Belongs to the glycosyl hydrolase family 6
GFS31_RS13520	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GFS31_RS13525	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GFS31_RS13530	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GFS31_RS13540	COG1136	(ABC) transporter
GFS31_RS13550	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GFS31_RS13570	COG1842	Phage shock protein A
GFS31_RS13595	COG0277	FAD linked oxidase domain protein
GFS31_RS13620	COG0047	phosphoribosylformylglycinamidine synthase activity
GFS31_RS13625	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GFS31_RS13630	COG0735	belongs to the Fur family
GFS31_RS13635	COG0148	phosphopyruvate hydratase activity
GFS31_RS13650	COG0848	biopolymer transport protein
GFS31_RS13655	COG0811	peptide transport
GFS31_RS13660	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GFS31_RS13665	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GFS31_RS13670	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GFS31_RS13675	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
GFS31_RS13680	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GFS31_RS13685	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GFS31_RS13705	COG2239	Acts as a magnesium transporter
GFS31_RS13710	COG2239	Acts as a magnesium transporter
GFS31_RS13715	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
GFS31_RS13720	COG0735	belongs to the Fur family
GFS31_RS13730	COG0783	Belongs to the Dps family
GFS31_RS13750	COG1840	ABC-type Fe3 transport system, periplasmic component
GFS31_RS13775	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GFS31_RS13780	COG1121	(ABC) transporter
GFS31_RS13785	COG0803	Belongs to the bacterial solute-binding protein 9 family
GFS31_RS13795	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GFS31_RS13825	COG1653	transport
GFS31_RS13830	COG2885	chlorophyll binding
GFS31_RS13835	COG2885	chlorophyll binding
GFS31_RS13855	COG1216	Glycosyl transferase, family 2
GFS31_RS13860	COG0824	Thioesterase
GFS31_RS13865	COG0739	heme binding
GFS31_RS13865	COG1196	nuclear chromosome segregation
GFS31_RS13865	COG0741	lytic transglycosylase activity
GFS31_RS13875	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GFS31_RS13880	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GFS31_RS13890	COG0724	RNA recognition motif
GFS31_RS13895	COG1132	(ABC) transporter
GFS31_RS13900	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GFS31_RS13905	COG1132	(ABC) transporter
GFS31_RS13910	COG1132	(ABC) transporter
GFS31_RS13955	COG1252	NADH dehydrogenase
GFS31_RS13970	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GFS31_RS13985	COG4948	Mandelate Racemase Muconate Lactonizing
GFS31_RS13995	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GFS31_RS14000	COG0563	adenylate kinase activity
GFS31_RS14005	COG0201	protein transport
GFS31_RS14010	COG0200	Binds to the 23S rRNA
GFS31_RS14015	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GFS31_RS14020	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
GFS31_RS14025	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GFS31_RS14030	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GFS31_RS14035	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GFS31_RS14040	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GFS31_RS14045	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GFS31_RS14050	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GFS31_RS14055	COG0255	Belongs to the universal ribosomal protein uL29 family
GFS31_RS14060	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GFS31_RS14065	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GFS31_RS14070	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GFS31_RS14075	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GFS31_RS14080	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GFS31_RS14085	COG0089	rRNA binding
GFS31_RS14090	COG0088	Forms part of the polypeptide exit tunnel
GFS31_RS14095	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GFS31_RS14110	COG3854	ATPases associated with a variety of cellular activities
GFS31_RS14120	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GFS31_RS14125	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GFS31_RS14130	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GFS31_RS14135	COG0202	RNA polymerase activity
GFS31_RS14140	COG0203	ribosomal protein L17
GFS31_RS14145	COG0101	tRNA pseudouridine synthase activity
GFS31_RS14150	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GFS31_RS14155	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GFS31_RS14160	COG0254	rRNA binding
GFS31_RS14165	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GFS31_RS14170	COG0420	3'-5' exonuclease activity
GFS31_RS14200	COG0668	transmembrane transport
GFS31_RS14215	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
GFS31_RS14250	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GFS31_RS14315	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
GFS31_RS14340	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GFS31_RS14350	COG1653	transport
GFS31_RS14355	COG0285	dihydrofolate synthase activity
GFS31_RS14360	COG0347	Belongs to the P(II) protein family
GFS31_RS14370	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GFS31_RS14385	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GFS31_RS14390	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GFS31_RS14405	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
GFS31_RS14405	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
GFS31_RS14425	COG1413	lyase activity
GFS31_RS14430	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GFS31_RS14460	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GFS31_RS14465	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GFS31_RS14470	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GFS31_RS14475	COG1773	rubredoxin
GFS31_RS14480	COG4447	cellulose binding
GFS31_RS14505	COG0726	polysaccharide deacetylase
GFS31_RS14505	COG1649	PFAM Uncharacterised BCR, COG1649
GFS31_RS14510	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GFS31_RS14515	COG1530	ribonuclease E activity
GFS31_RS14520	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
GFS31_RS14525	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GFS31_RS14530	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GFS31_RS14535	COG0544	peptidyl-prolyl cis-trans isomerase activity
GFS31_RS14540	COG0740	serine-type endopeptidase activity
GFS31_RS14545	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GFS31_RS14585	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GFS31_RS14610	COG2217	Heavy metal translocating P-type atpase
GFS31_RS14625	COG2244	polysaccharide biosynthetic process
GFS31_RS14630	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GFS31_RS14635	COG0051	transcription antitermination factor activity, RNA binding
GFS31_RS14640	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GFS31_RS14645	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GFS31_RS14650	COG0049	tRNA binding
GFS31_RS14655	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GFS31_RS14660	COG0316	Belongs to the HesB IscA family
GFS31_RS14675	COG0070	glutamate synthase
GFS31_RS14675	COG0069	glutamate synthase activity
GFS31_RS14675	COG0067	glutamate synthase
GFS31_RS14680	COG0592	DNA-directed DNA polymerase activity
GFS31_RS14700	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GFS31_RS14725	COG0523	cobalamin synthesis protein
GFS31_RS14730	COG1012	belongs to the aldehyde dehydrogenase family
GFS31_RS14730	COG1454	alcohol dehydrogenase
GFS31_RS14745	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GFS31_RS14750	COG0460	homoserine dehydrogenase
GFS31_RS14760	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GFS31_RS14760	COG0189	ligase activity
GFS31_RS14770	COG0247	lactate metabolic process
GFS31_RS14775	COG0793	Belongs to the peptidase S41A family
GFS31_RS14780	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GFS31_RS14820	COG3659	wide pore channel activity
GFS31_RS14825	COG3659	wide pore channel activity
GFS31_RS14830	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
GFS31_RS14835	COG2226	methyltransferase
GFS31_RS14855	COG2197	response regulator
GFS31_RS14860	COG0124	histidyl-tRNA synthetase
GFS31_RS14870	COG2890	protein-(glutamine-N5) methyltransferase activity
GFS31_RS14875	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GFS31_RS14885	COG2885	chlorophyll binding
GFS31_RS14890	COG2885	chlorophyll binding
GFS31_RS14895	COG1691	(AIR) carboxylase
GFS31_RS14905	COG1722	exodeoxyribonuclease VII activity
GFS31_RS14910	COG2226	methyltransferase
GFS31_RS14915	COG4399	Belongs to the UPF0754 family
GFS31_RS14920	COG0850	regulation of cytokinetic process
GFS31_RS14935	COG0804	urea catabolic process
GFS31_RS14940	COG0515	serine threonine protein kinase
GFS31_RS14950	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
GFS31_RS14955	COG0569	domain protein
GFS31_RS14960	COG0516	GMP reductase activity
GFS31_RS14965	COG3118	belongs to the thioredoxin family
GFS31_RS14975	COG2144	transferase activity, transferring acyl groups
GFS31_RS14980	COG0438	transferase activity, transferring glycosyl groups
GFS31_RS14990	COG2153	protein acetylation
GFS31_RS15010	COG2072	flavoprotein involved in K transport
GFS31_RS15015	COG2197	response regulator
GFS31_RS15020	COG0539	negative regulation of cytoplasmic translation
GFS31_RS15030	COG0395	ABC-type sugar transport system, permease component
GFS31_RS15040	COG0420	3'-5' exonuclease activity
GFS31_RS15050	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
GFS31_RS15080	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GFS31_RS15090	COG1546	Belongs to the CinA family
GFS31_RS15090	COG1058	Belongs to the CinA family
GFS31_RS15095	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
GFS31_RS15110	COG0604	alcohol dehydrogenase
GFS31_RS15110	COG1028	Short-chain dehydrogenase reductase Sdr
GFS31_RS15110	COG3321	synthase
GFS31_RS15135	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
GFS31_RS15140	COG0351	phosphomethylpyrimidine kinase
GFS31_RS15140	COG0352	thiamine-phosphate diphosphorylase activity
GFS31_RS15140	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
GFS31_RS15155	COG5002	protein histidine kinase activity
GFS31_RS15170	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GFS31_RS15195	COG0515	serine threonine protein kinase
GFS31_RS15220	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GFS31_RS15225	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GFS31_RS15245	COG0138	bifunctional purine biosynthesis protein purh
GFS31_RS15255	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
GFS31_RS15260	COG1372	Participates in initiation and elongation during chromosome replication
GFS31_RS15260	COG0187	DNA topoisomerase II activity
GFS31_RS15265	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GFS31_RS15295	COG0436	Aminotransferase
GFS31_RS15310	COG2255	four-way junction helicase activity
GFS31_RS15380	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GFS31_RS15385	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GFS31_RS15465	COG3341	Caulimovirus viroplasmin
GFS31_RS15465	COG0328	RNA-DNA hybrid ribonuclease activity
GFS31_RS15475	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
GFS31_RS15480	COG2189	Belongs to the N(4) N(6)-methyltransferase family
GFS31_RS15485	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
GFS31_RS15500	COG2867	negative regulation of translational initiation
GFS31_RS15505	COG2202	Pas domain
GFS31_RS15505	COG2205	protein histidine kinase activity
GFS31_RS15510	COG2205	protein histidine kinase activity
GFS31_RS15510	COG4999	Histidine kinase
GFS31_RS15510	COG3437	response regulator, receiver
GFS31_RS15510	COG3850	Histidine kinase
GFS31_RS15530	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
GFS31_RS15550	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GFS31_RS15565	COG0484	heat shock protein binding
GFS31_RS15575	COG2385	sporulation resulting in formation of a cellular spore
GFS31_RS15580	COG2304	oxidoreductase activity
GFS31_RS15590	COG1834	amidinotransferase
GFS31_RS15595	COG0513	Belongs to the DEAD box helicase family
GFS31_RS15600	COG3706	GGDEF domain
GFS31_RS15600	COG2203	Gaf domain
GFS31_RS15600	COG5001	Diguanylate cyclase
GFS31_RS15600	COG4251	negative regulation of phosphorylation
GFS31_RS15605	COG1035	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus
GFS31_RS15610	COG1940	carbohydrate kinase activity
GFS31_RS15625	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GFS31_RS15630	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GFS31_RS15635	COG0697	spore germination
GFS31_RS15645	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
GFS31_RS15650	COG0375	protein maturation
GFS31_RS15655	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GFS31_RS15655	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GFS31_RS15675	COG0740	serine-type endopeptidase activity
GFS31_RS15685	COG0861	Integral membrane protein TerC family
GFS31_RS15710	COG0391	Required for morphogenesis under gluconeogenic growth conditions
GFS31_RS15715	COG3237	CsbD-like
GFS31_RS15720	COG0126	phosphoglycerate kinase activity
GFS31_RS15725	COG0589	response to stress
GFS31_RS15735	COG0484	heat shock protein binding
GFS31_RS15755	COG1480	7TM receptor with intracellular HD hydrolase
GFS31_RS15770	COG0515	serine threonine protein kinase
GFS31_RS15780	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GFS31_RS15800	COG0058	SHG alpha-glucan phosphorylase activity
GFS31_RS15805	COG1562	ergosterol biosynthetic process
GFS31_RS15810	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GFS31_RS15815	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GFS31_RS15820	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
GFS31_RS15830	COG2205	protein histidine kinase activity
GFS31_RS15835	COG0193	aminoacyl-tRNA hydrolase activity
GFS31_RS15840	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GFS31_RS15855	COG0228	four-way junction DNA binding
GFS31_RS15865	COG1702	phosphate starvation-inducible protein PhoH
GFS31_RS15875	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
GFS31_RS15880	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GFS31_RS15885	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
GFS31_RS15885	COG0674	pyruvate-flavodoxin oxidoreductase activity
GFS31_RS15885	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
GFS31_RS15885	COG1013	pyruvate-flavodoxin oxidoreductase activity
GFS31_RS15890	COG0167	dihydroorotate dehydrogenase activity
GFS31_RS15940	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GFS31_RS15945	COG1672	PFAM Archaeal ATPase
GFS31_RS15950	COG0783	Belongs to the Dps family
GFS31_RS15960	COG0336	Belongs to the RNA methyltransferase TrmD family
GFS31_RS15965	COG4242	Belongs to the peptidase S51 family
GFS31_RS15970	COG0386	Belongs to the glutathione peroxidase family
GFS31_RS15980	COG3932	Exopolysaccharide synthesis, ExoD
GFS31_RS15985	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GFS31_RS16000	COG1078	dGTPase activity
GFS31_RS16005	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GFS31_RS16015	COG0601	transmembrane transport
GFS31_RS16035	COG4251	negative regulation of phosphorylation
GFS31_RS16050	COG0484	heat shock protein binding
GFS31_RS16160	COG1160	GTP binding
GFS31_RS16175	COG1713	HD superfamily hydrolase involved in NAD metabolism
GFS31_RS16180	COG0799	negative regulation of ribosome biogenesis
GFS31_RS16185	COG1215	transferase activity, transferring glycosyl groups
GFS31_RS16190	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
GFS31_RS16210	COG2703	oxygen carrier activity
GFS31_RS16215	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
GFS31_RS16220	COG1959	2 iron, 2 sulfur cluster binding
GFS31_RS16240	COG5002	protein histidine kinase activity
GFS31_RS16255	COG0815	Transfers the fatty acyl group on membrane lipoproteins
GFS31_RS16265	COG0431	NADPH-dependent FMN reductase
GFS31_RS16280	COG0789	Transcriptional regulator
GFS31_RS16285	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GFS31_RS16295	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GFS31_RS16300	COG0497	DNA recombination
GFS31_RS16305	COG0724	RNA recognition motif
GFS31_RS16310	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GFS31_RS16315	COG2211	Major facilitator Superfamily
GFS31_RS16320	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
GFS31_RS16340	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GFS31_RS16350	COG0632	four-way junction helicase activity
GFS31_RS16355	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GFS31_RS16375	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GFS31_RS16380	COG0484	heat shock protein binding
GFS31_RS16385	COG0443	Heat shock 70 kDa protein
GFS31_RS16400	COG2258	MOSC domain
GFS31_RS16425	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GFS31_RS16430	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GFS31_RS16445	COG0358	DNA primase activity
GFS31_RS16450	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GFS31_RS16470	COG1028	Short-chain dehydrogenase reductase Sdr
GFS31_RS16475	COG0572	uridine kinase
GFS31_RS16480	COG0825	malonyl-CoA metabolic process
GFS31_RS16485	COG0300	oxidoreductase activity
GFS31_RS16490	COG0302	gtp cyclohydrolase
GFS31_RS16495	COG0033	Phosphoglucomutase
GFS31_RS16505	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GFS31_RS16515	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GFS31_RS16515	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GFS31_RS16520	COG0154	amidase activity
GFS31_RS16525	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GFS31_RS16535	COG3300	MHYT domain
GFS31_RS16535	COG5001	Diguanylate cyclase
GFS31_RS16560	COG0443	Heat shock 70 kDa protein
GFS31_RS16575	COG0314	molybdopterin synthase activity
GFS31_RS16585	COG1216	Glycosyl transferase, family 2
GFS31_RS16595	COG1215	transferase activity, transferring glycosyl groups
GFS31_RS16605	COG3631	Ketosteroid isomerase-related protein
GFS31_RS16620	COG3046	protein related to deoxyribodipyrimidine photolyase
GFS31_RS16635	COG2045	Belongs to the ComB family
GFS31_RS16660	COG0583	DNA-binding transcription factor activity
GFS31_RS16675	COG2202	Pas domain
GFS31_RS16675	COG2205	protein histidine kinase activity
GFS31_RS16680	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
GFS31_RS16690	COG0537	adenosine 5'-monophosphoramidase activity
GFS31_RS16695	COG1672	PFAM Archaeal ATPase
GFS31_RS16700	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GFS31_RS16705	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GFS31_RS16710	COG3437	response regulator, receiver
GFS31_RS16720	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GFS31_RS16720	COG0426	domain, Protein
GFS31_RS16735	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GFS31_RS16745	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
GFS31_RS16755	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GFS31_RS16760	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
GFS31_RS16765	COG0667	Aldo Keto reductase
GFS31_RS16775	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
GFS31_RS16780	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GFS31_RS16795	COG0385	Bile acid
GFS31_RS16800	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GFS31_RS16810	COG0154	amidase activity
GFS31_RS16845	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GFS31_RS16860	COG0142	geranyltranstransferase activity
GFS31_RS16870	COG2954	triphosphatase activity
GFS31_RS16895	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GFS31_RS16905	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GFS31_RS16910	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
GFS31_RS16915	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GFS31_RS16930	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
GFS31_RS16940	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GFS31_RS16950	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GFS31_RS16955	COG0470	DNA polymerase III
GFS31_RS16960	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GFS31_RS16970	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GFS31_RS17005	COG1598	PFAM Uncharacterised protein family UPF0150
GFS31_RS17035	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GFS31_RS17035	COG2022	thiamine diphosphate biosynthetic process
GFS31_RS17050	COG0745	RESPONSE REGULATOR receiver
GFS31_RS17070	COG0024	Methionine aminopeptidase
GFS31_RS17085	COG4636	protein conserved in cyanobacteria
GFS31_RS17100	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GFS31_RS17135	COG4783	chaperone-mediated protein folding
GFS31_RS17145	COG0501	Belongs to the peptidase M48B family
GFS31_RS17180	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GFS31_RS17190	COG2351	hydroxyisourate hydrolase activity
GFS31_RS17200	COG1410	methionine synthase
GFS31_RS17200	COG0646	methionine synthase
GFS31_RS17230	COG0024	Methionine aminopeptidase
GFS31_RS17235	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
GFS31_RS17250	COG2205	protein histidine kinase activity
GFS31_RS17250	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GFS31_RS17255	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GFS31_RS17265	COG1716	ATPase activity
GFS31_RS17265	COG5001	Diguanylate cyclase
GFS31_RS17270	COG1716	ATPase activity
GFS31_RS17270	COG5001	Diguanylate cyclase
GFS31_RS17305	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GFS31_RS17330	COG0277	FAD linked oxidase domain protein
GFS31_RS17335	COG1442	glycosyl transferase family 8
GFS31_RS17350	COG0140	phosphoribosyl-ATP diphosphatase activity
GFS31_RS17350	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GFS31_RS17360	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GFS31_RS17365	COG1472	Belongs to the glycosyl hydrolase 3 family
GFS31_RS17410	COG1333	cytochrome c biogenesis protein
GFS31_RS17415	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
GFS31_RS17420	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GFS31_RS17430	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GFS31_RS17435	COG1799	cell septum assembly
GFS31_RS17440	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GFS31_RS17450	COG3706	GGDEF domain
GFS31_RS17450	COG5001	Diguanylate cyclase
GFS31_RS17450	COG4251	negative regulation of phosphorylation
GFS31_RS17450	COG2203	Gaf domain
GFS31_RS17455	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GFS31_RS17465	COG2226	methyltransferase
GFS31_RS17495	COG0310	cobalt ion transport
GFS31_RS17505	COG1122	ATPase activity
GFS31_RS17535	COG0076	glutamate decarboxylase activity
GFS31_RS17550	COG0672	)-iron permease
GFS31_RS17555	COG0745	RESPONSE REGULATOR receiver
GFS31_RS17565	COG0315	cyclic pyranopterin monophosphate synthase activity
GFS31_RS17585	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
GFS31_RS17590	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
GFS31_RS17595	COG5433	transposase activity
GFS31_RS17600	COG4372	Transposase
GFS31_RS17620	COG0012	GTP binding
GFS31_RS17630	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GFS31_RS17635	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GFS31_RS17650	COG0644	oxidoreductase
GFS31_RS17665	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GFS31_RS17670	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
GFS31_RS17675	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GFS31_RS17680	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GFS31_RS17690	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GFS31_RS17710	COG0538	isocitrate dehydrogenase activity
GFS31_RS17715	COG0745	RESPONSE REGULATOR receiver
GFS31_RS17735	COG0728	peptidoglycan biosynthetic process
GFS31_RS17745	COG0588	phosphoglycerate mutase activity
GFS31_RS17750	COG3119	arylsulfatase activity
GFS31_RS17770	COG4106	trans-aconitate 2-methyltransferase activity
GFS31_RS17775	COG4636	protein conserved in cyanobacteria
GFS31_RS17780	COG0714	Associated with various cellular activities
GFS31_RS17785	COG0196	riboflavin kinase activity
GFS31_RS17790	COG1234	tRNA 3'-trailer cleavage
GFS31_RS17805	COG2161	toxin-antitoxin pair type II binding
GFS31_RS17810	COG4115	mRNA cleavage
GFS31_RS17835	COG1053	succinate dehydrogenase
GFS31_RS17845	COG2860	membrane
GFS31_RS17860	COG5002	protein histidine kinase activity
GFS31_RS17885	COG0438	transferase activity, transferring glycosyl groups
GFS31_RS17890	COG1132	(ABC) transporter
GFS31_RS17900	COG2886	Uncharacterised protein family (UPF0175)
GFS31_RS17910	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GFS31_RS17915	COG0058	SHG alpha-glucan phosphorylase activity
GFS31_RS17920	COG0460	homoserine dehydrogenase
GFS31_RS17940	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
GFS31_RS17960	COG0659	secondary active sulfate transmembrane transporter activity
GFS31_RS17965	COG0589	response to stress
GFS31_RS17970	COG0659	secondary active sulfate transmembrane transporter activity
GFS31_RS17975	COG3118	belongs to the thioredoxin family
GFS31_RS17980	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GFS31_RS17990	COG2208	phosphoserine phosphatase activity
GFS31_RS17995	COG2099	Precorrin-6x reductase
GFS31_RS18010	COG1511	domain protein
GFS31_RS18010	COG3264	Mechanosensitive ion channel
GFS31_RS18030	COG1473	amidohydrolase
GFS31_RS18035	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GFS31_RS18075	COG1193	negative regulation of DNA recombination
GFS31_RS18080	COG0515	serine threonine protein kinase
GFS31_RS18080	COG1357	PFAM Pentapeptide repeats (8 copies)
GFS31_RS18130	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GFS31_RS18130	COG0574	Belongs to the PEP-utilizing enzyme family
GFS31_RS18135	COG0681	Belongs to the peptidase S26 family
GFS31_RS18150	COG2962	Rard protein
GFS31_RS18160	COG0495	leucyl-tRNA aminoacylation
GFS31_RS18170	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GFS31_RS18180	COG0589	response to stress
GFS31_RS18185	COG0592	DNA-directed DNA polymerase activity
GFS31_RS18190	COG0300	oxidoreductase activity
GFS31_RS18200	COG0305	Participates in initiation and elongation during chromosome replication
GFS31_RS18200	COG1372	Participates in initiation and elongation during chromosome replication
GFS31_RS18205	COG0359	binds to the 23S rRNA
GFS31_RS18225	COG0149	triose-phosphate isomerase activity
GFS31_RS18240	COG1185	polyribonucleotide nucleotidyltransferase activity
GFS31_RS18255	COG3956	TIGRFAM MazG family protein
GFS31_RS18275	COG2010	Cytochrome c
GFS31_RS18325	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GFS31_RS18325	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GFS31_RS18330	COG0432	Pfam Uncharacterised protein family UPF0047
GFS31_RS18340	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
GFS31_RS18345	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GFS31_RS18365	COG0312	modulator of DNA gyrase
GFS31_RS18370	COG2095	MarC family integral membrane protein
GFS31_RS18385	COG0405	Gamma-glutamyltransferase
GFS31_RS18390	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
GFS31_RS18400	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GFS31_RS18410	COG2154	pterin-4-alpha-carbinolamine dehydratase
GFS31_RS18415	COG0157	Belongs to the NadC ModD family
GFS31_RS18420	COG3706	GGDEF domain
GFS31_RS18420	COG4251	negative regulation of phosphorylation
GFS31_RS18420	COG2203	Gaf domain
GFS31_RS18420	COG5001	Diguanylate cyclase
GFS31_RS18425	COG2770	Histidine kinase
GFS31_RS18425	COG2208	phosphoserine phosphatase activity
GFS31_RS18440	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GFS31_RS18440	COG0758	DNA mediated transformation
GFS31_RS18450	COG3239	Fatty acid desaturase
GFS31_RS18465	COG0129	dihydroxy-acid dehydratase activity
GFS31_RS18490	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
GFS31_RS18495	COG0488	(ABC) transporter
GFS31_RS18505	COG1028	Short-chain dehydrogenase reductase Sdr
GFS31_RS18510	COG0857	belongs to the CobB CobQ family
GFS31_RS18510	COG0280	phosphate acetyltransferase
GFS31_RS18515	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GFS31_RS18530	COG2199	diguanylate cyclase activity
GFS31_RS18530	COG2203	Gaf domain
GFS31_RS18560	COG1131	(ABC) transporter
GFS31_RS18580	COG1121	(ABC) transporter
GFS31_RS18585	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GFS31_RS18590	COG0418	dihydroorotase activity
GFS31_RS18610	COG3688	RNA-binding protein containing a PIN domain
GFS31_RS18655	COG0107	imidazoleglycerol-phosphate synthase activity
GFS31_RS18670	COG1028	Short-chain dehydrogenase reductase Sdr
GFS31_RS18685	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GFS31_RS18695	COG0434	BtpA family
GFS31_RS18715	COG0251	oxidation-reduction process
GFS31_RS18720	COG1253	flavin adenine dinucleotide binding
GFS31_RS18725	COG4172	Belongs to the ABC transporter superfamily
GFS31_RS18730	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GFS31_RS18750	COG0508	dehydrogenase complex catalyzes the overall conversion of
GFS31_RS18770	COG1968	undecaprenyl-diphosphatase activity
GFS31_RS18800	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
GFS31_RS18805	COG3118	belongs to the thioredoxin family
GFS31_RS18895	COG4956	integral membrane protein (PIN domain superfamily)
GFS31_RS18915	COG0482	sulfurtransferase activity
GFS31_RS18925	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
GFS31_RS18940	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GFS31_RS18950	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GFS31_RS18965	COG2082	Precorrin-8x methylmutase
GFS31_RS18990	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GFS31_RS19000	COG0564	pseudouridine synthase activity
GFS31_RS19030	COG5002	protein histidine kinase activity
GFS31_RS19035	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GFS31_RS19045	COG0191	fructose-bisphosphate aldolase activity
GFS31_RS19055	COG0083	homoserine kinase activity
GFS31_RS19075	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GFS31_RS19120	COG1671	Belongs to the UPF0178 family
GFS31_RS19130	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GFS31_RS19135	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GFS31_RS19140	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GFS31_RS19260	COG0745	RESPONSE REGULATOR receiver
GFS31_RS19265	COG5002	protein histidine kinase activity
GFS31_RS19270	COG1111	helicase
GFS31_RS19270	COG1205	dead DEAH box helicase
GFS31_RS19285	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
GFS31_RS19355	COG1518	maintenance of DNA repeat elements
GFS31_RS19355	COG1468	defense response to virus
GFS31_RS19435	COG0601	transmembrane transport
GFS31_RS19440	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GFS31_RS19445	COG1126	abc transporter atp-binding protein
GFS31_RS19450	COG4608	Belongs to the ABC transporter superfamily
GFS31_RS19460	COG2202	Pas domain
GFS31_RS19460	COG2205	protein histidine kinase activity
GFS31_RS19465	COG0402	S-adenosylhomocysteine deaminase activity
GFS31_RS19475	COG0154	amidase activity
GFS31_RS19530	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GFS31_RS19540	COG1061	Type III restriction enzyme res subunit
GFS31_RS19595	COG5002	protein histidine kinase activity
GFS31_RS19600	COG0745	RESPONSE REGULATOR receiver
GFS31_RS19825	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GFS31_RS19830	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GFS31_RS19830	COG0723	plastoquinol--plastocyanin reductase activity
GFS31_RS19845	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
GFS31_RS19855	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
GFS31_RS19980	COG3706	GGDEF domain
GFS31_RS19990	COG1716	ATPase activity
GFS31_RS19990	COG5001	Diguanylate cyclase
GFS31_RS20020	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GFS31_RS20025	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GFS31_RS20065	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GFS31_RS20085	COG2319	Wd-40 repeat
GFS31_RS20085	COG3903	Transcriptional regulator
GFS31_RS20115	COG1309	transcriptional regulator
GFS31_RS20120	COG1136	(ABC) transporter
GFS31_RS20130	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GFS31_RS20135	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GFS31_RS20165	COG2271	Major facilitator Superfamily
GFS31_RS20175	COG3119	arylsulfatase activity
GFS31_RS20190	COG4636	protein conserved in cyanobacteria
GFS31_RS20205	COG0737	Belongs to the 5'-nucleotidase family
GFS31_RS20220	COG1475	DNA binding
GFS31_RS20225	COG1192	Involved in chromosome partitioning
GFS31_RS20240	COG3273	potassium ion transport
GFS31_RS20240	COG0471	metal ion transport
GFS31_RS20265	COG4208	sulfate ABC transporter
GFS31_RS20270	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
GFS31_RS20275	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
GFS31_RS20280	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
GFS31_RS20285	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GFS31_RS20310	COG0523	cobalamin synthesis protein
GFS31_RS20315	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GFS31_RS20320	COG1121	(ABC) transporter
GFS31_RS20325	COG0803	Belongs to the bacterial solute-binding protein 9 family
GFS31_RS20330	COG0113	porphobilinogen synthase activity
GFS31_RS20340	COG0523	cobalamin synthesis protein
GFS31_RS20355	COG0811	peptide transport
GFS31_RS20360	COG0848	biopolymer transport protein
GFS31_RS20390	COG1120	ATPase activity
GFS31_RS20415	COG3239	Fatty acid desaturase
GFS31_RS20420	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GFS31_RS20440	COG1475	DNA binding
GFS31_RS20445	COG1192	Involved in chromosome partitioning
GFS31_RS20450	COG0174	glutamine synthetase
GFS31_RS20505	COG4521	taurine ABC transporter
GFS31_RS20510	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GFS31_RS20520	COG0583	DNA-binding transcription factor activity
GFS31_RS20540	COG0489	protein tyrosine kinase activity
GFS31_RS20550	COG2855	membrane
GFS31_RS20615	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GFS31_RS20705	COG1192	Involved in chromosome partitioning
GFS31_RS20750	COG2442	InterPro IPR007367
GFS31_RS20785	COG4636	protein conserved in cyanobacteria
GFS31_RS20815	COG1104	cysteine desulfurase activity
GFS31_RS20820	COG1192	Involved in chromosome partitioning