locus-tag	class	description
LEP3755_RS00025	COG1657	PFAM Prenyltransferase squalene oxidase
LEP3755_RS00030	COG0463	Glycosyl transferase, family 2
LEP3755_RS00040	COG0482	sulfurtransferase activity
LEP3755_RS00045	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
LEP3755_RS00075	COG3001	Fructosamine kinase
LEP3755_RS00080	COG0612	Peptidase, M16
LEP3755_RS00095	COG1028	Short-chain dehydrogenase reductase Sdr
LEP3755_RS00125	COG0589	response to stress
LEP3755_RS00130	COG1573	uracil-dna glycosylase
LEP3755_RS00180	COG0546	phosphoglycolate phosphatase activity
LEP3755_RS00185	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
LEP3755_RS00190	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
LEP3755_RS00195	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
LEP3755_RS00200	COG3429	Glucose-6-phosphate dehydrogenase subunit
LEP3755_RS00200	COG3409	Peptidoglycan-binding domain 1 protein
LEP3755_RS00205	COG1797	cobyrinic acid a,c-diamide synthase activity
LEP3755_RS00230	COG3546	catalase activity
LEP3755_RS00235	COG2226	methyltransferase
LEP3755_RS00265	COG0275	rRNA processing
LEP3755_RS00270	COG0649	NAD binding
LEP3755_RS00285	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
LEP3755_RS00290	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
LEP3755_RS00295	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
LEP3755_RS00305	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
LEP3755_RS00315	COG0129	dihydroxy-acid dehydratase activity
LEP3755_RS00320	COG0583	DNA-binding transcription factor activity
LEP3755_RS00330	COG0501	Belongs to the peptidase M48B family
LEP3755_RS00355	COG3291	Pkd domain containing protein
LEP3755_RS00365	COG2154	pterin-4-alpha-carbinolamine dehydratase
LEP3755_RS00375	COG1615	UPF0182 protein
LEP3755_RS00385	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
LEP3755_RS00390	COG1959	2 iron, 2 sulfur cluster binding
LEP3755_RS00400	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
LEP3755_RS00405	COG4948	Mandelate Racemase Muconate Lactonizing
LEP3755_RS00415	COG0426	domain, Protein
LEP3755_RS00415	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LEP3755_RS00420	COG0426	domain, Protein
LEP3755_RS00420	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LEP3755_RS00425	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
LEP3755_RS00435	COG2197	response regulator
LEP3755_RS00445	COG0165	Argininosuccinate lyase
LEP3755_RS00450	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
LEP3755_RS00455	COG0494	nUDIX hydrolase
LEP3755_RS00470	COG3000	fatty acid hydroxylase
LEP3755_RS00470	COG0300	oxidoreductase activity
LEP3755_RS00485	COG0438	transferase activity, transferring glycosyl groups
LEP3755_RS00490	COG0142	geranyltranstransferase activity
LEP3755_RS00500	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
LEP3755_RS00505	COG0860	N-Acetylmuramoyl-L-alanine amidase
LEP3755_RS00505	COG2247	cell wall binding repeat
LEP3755_RS00510	COG0475	glutathione-regulated potassium exporter activity
LEP3755_RS00525	COG2205	protein histidine kinase activity
LEP3755_RS00525	COG0784	Response regulator, receiver
LEP3755_RS00530	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LEP3755_RS00530	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LEP3755_RS00555	COG0277	FAD linked oxidase domain protein
LEP3755_RS00565	COG0243	molybdopterin cofactor binding
LEP3755_RS00575	COG1116	anion transmembrane transporter activity
LEP3755_RS00580	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LEP3755_RS00580	COG1116	anion transmembrane transporter activity
LEP3755_RS00585	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LEP3755_RS00590	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LEP3755_RS00610	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
LEP3755_RS00645	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LEP3755_RS00650	COG0193	aminoacyl-tRNA hydrolase activity
LEP3755_RS00680	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
LEP3755_RS00720	COG3850	Histidine kinase
LEP3755_RS00720	COG3437	response regulator, receiver
LEP3755_RS00720	COG2205	protein histidine kinase activity
LEP3755_RS00720	COG4999	Histidine kinase
LEP3755_RS00730	COG0481	GTPase activity
LEP3755_RS00735	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LEP3755_RS00740	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
LEP3755_RS00755	COG0582	viral genome integration into host DNA
LEP3755_RS00870	COG0582	viral genome integration into host DNA
LEP3755_RS00885	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
LEP3755_RS00885	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
LEP3755_RS00895	COG0312	modulator of DNA gyrase
LEP3755_RS00900	COG0312	modulator of DNA gyrase
LEP3755_RS00905	COG3659	wide pore channel activity
LEP3755_RS00925	COG0747	negative chemotaxis
LEP3755_RS00940	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LEP3755_RS00955	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
LEP3755_RS00960	COG1473	amidohydrolase
LEP3755_RS00970	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
LEP3755_RS01020	COG0534	Mate efflux family protein
LEP3755_RS01025	COG1487	ribonuclease activity
LEP3755_RS01050	COG0180	Tryptophanyl-tRNA synthetase
LEP3755_RS01070	COG2144	transferase activity, transferring acyl groups
LEP3755_RS01095	COG2072	flavoprotein involved in K transport
LEP3755_RS01105	COG2909	trisaccharide binding
LEP3755_RS01110	COG3118	belongs to the thioredoxin family
LEP3755_RS01135	COG1012	belongs to the aldehyde dehydrogenase family
LEP3755_RS01170	COG0450	alkyl hydroperoxide reductase
LEP3755_RS01180	COG5002	protein histidine kinase activity
LEP3755_RS01185	COG2197	response regulator
LEP3755_RS01190	COG0668	transmembrane transport
LEP3755_RS01230	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
LEP3755_RS01235	COG0586	Pfam SNARE associated Golgi protein
LEP3755_RS01265	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
LEP3755_RS01265	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LEP3755_RS01295	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LEP3755_RS01325	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
LEP3755_RS01335	COG0525	valine-tRNA ligase activity
LEP3755_RS01360	COG2233	PERMEase
LEP3755_RS01365	COG2814	Major facilitator Superfamily
LEP3755_RS01405	COG2205	protein histidine kinase activity
LEP3755_RS01405	COG3850	Histidine kinase
LEP3755_RS01405	COG4999	Histidine kinase
LEP3755_RS01405	COG3437	response regulator, receiver
LEP3755_RS01410	COG3266	domain, Protein
LEP3755_RS01410	COG0515	serine threonine protein kinase
LEP3755_RS01415	COG0515	serine threonine protein kinase
LEP3755_RS01415	COG3266	domain, Protein
LEP3755_RS01435	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
LEP3755_RS01445	COG0023	Translation Initiation Factor
LEP3755_RS01450	COG1834	amidinotransferase
LEP3755_RS01470	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
LEP3755_RS01500	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
LEP3755_RS01505	COG4251	negative regulation of phosphorylation
LEP3755_RS01510	COG0390	transport system, permease component
LEP3755_RS01520	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
LEP3755_RS01545	COG0643	Histidine kinase
LEP3755_RS01545	COG0784	Response regulator, receiver
LEP3755_RS01545	COG2198	Histidine kinase
LEP3755_RS01550	COG0840	transmembrane signaling receptor activity
LEP3755_RS01550	COG2203	Gaf domain
LEP3755_RS01580	COG3659	wide pore channel activity
LEP3755_RS01585	COG1802	Transcriptional regulator
LEP3755_RS01590	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LEP3755_RS01595	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
LEP3755_RS01605	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
LEP3755_RS01615	COG0463	Glycosyl transferase, family 2
LEP3755_RS01620	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LEP3755_RS01660	COG0469	pyruvate kinase activity
LEP3755_RS01690	COG0438	transferase activity, transferring glycosyl groups
LEP3755_RS01695	COG1132	(ABC) transporter
LEP3755_RS01700	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
LEP3755_RS01705	COG0489	protein tyrosine kinase activity
LEP3755_RS01710	COG0438	transferase activity, transferring glycosyl groups
LEP3755_RS01725	COG0305	Participates in initiation and elongation during chromosome replication
LEP3755_RS01725	COG1372	Participates in initiation and elongation during chromosome replication
LEP3755_RS01730	COG0359	binds to the 23S rRNA
LEP3755_RS01760	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LEP3755_RS01765	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
LEP3755_RS01790	COG0697	spore germination
LEP3755_RS01805	COG1598	PFAM Uncharacterised protein family UPF0150
LEP3755_RS01830	COG1022	Amp-dependent synthetase and ligase
LEP3755_RS01840	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
LEP3755_RS01855	COG0784	Response regulator, receiver
LEP3755_RS01855	COG2205	protein histidine kinase activity
LEP3755_RS01855	COG2198	Histidine kinase
LEP3755_RS01865	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
LEP3755_RS01870	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LEP3755_RS01890	COG0306	phosphate transporter
LEP3755_RS01900	COG1304	FMN binding
LEP3755_RS01905	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
LEP3755_RS01910	COG0360	Binds together with S18 to 16S ribosomal RNA
LEP3755_RS01915	COG0179	Fumarylacetoacetate (FAA) hydrolase
LEP3755_RS01930	COG3437	response regulator, receiver
LEP3755_RS01935	COG4581	dead DEAH box helicase
LEP3755_RS01940	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
LEP3755_RS01955	COG0724	RNA recognition motif
LEP3755_RS01970	COG0463	Glycosyl transferase, family 2
LEP3755_RS01980	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LEP3755_RS01980	COG4191	Histidine kinase
LEP3755_RS01985	COG0784	Response regulator, receiver
LEP3755_RS01985	COG3437	response regulator, receiver
LEP3755_RS01990	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LEP3755_RS02015	COG4177	L-phenylalanine transmembrane transporter activity
LEP3755_RS02025	COG0410	ABC transporter
LEP3755_RS02040	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LEP3755_RS02040	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LEP3755_RS02090	COG2161	toxin-antitoxin pair type II binding
LEP3755_RS02140	COG0200	Binds to the 23S rRNA
LEP3755_RS02145	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
LEP3755_RS02150	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
LEP3755_RS02155	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
LEP3755_RS02160	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
LEP3755_RS02165	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
LEP3755_RS02170	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
LEP3755_RS02175	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
LEP3755_RS02180	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
LEP3755_RS02185	COG0255	Belongs to the universal ribosomal protein uL29 family
LEP3755_RS02195	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
LEP3755_RS02200	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
LEP3755_RS02205	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
LEP3755_RS02210	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
LEP3755_RS02215	COG0089	rRNA binding
LEP3755_RS02220	COG0088	Forms part of the polypeptide exit tunnel
LEP3755_RS02225	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
LEP3755_RS02255	COG2226	methyltransferase
LEP3755_RS02265	COG1662	PFAM IS1 transposase
LEP3755_RS02285	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LEP3755_RS02290	COG0783	Belongs to the Dps family
LEP3755_RS02295	COG5592	hemerythrin HHE cation binding domain
LEP3755_RS02300	COG0363	glucosamine-6-phosphate deaminase activity
LEP3755_RS02310	COG1028	Short-chain dehydrogenase reductase Sdr
LEP3755_RS02315	COG3932	Exopolysaccharide synthesis, ExoD
LEP3755_RS02320	COG3264	Mechanosensitive ion channel
LEP3755_RS02320	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
LEP3755_RS02335	COG0840	transmembrane signaling receptor activity
LEP3755_RS02340	COG0835	chemotaxis
LEP3755_RS02345	COG2198	Histidine kinase
LEP3755_RS02345	COG0643	Histidine kinase
LEP3755_RS02345	COG0784	Response regulator, receiver
LEP3755_RS02350	COG2201	protein-glutamate methylesterase activity
LEP3755_RS02355	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
LEP3755_RS02360	COG0714	Associated with various cellular activities
LEP3755_RS02385	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
LEP3755_RS02420	COG0018	arginyl-trna synthetase
LEP3755_RS02445	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LEP3755_RS02450	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LEP3755_RS02455	COG2197	response regulator
LEP3755_RS02465	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LEP3755_RS02475	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LEP3755_RS02505	COG1653	transport
LEP3755_RS02515	COG3293	Transposase
LEP3755_RS02535	COG1429	ligase activity, forming nitrogen-metal bonds
LEP3755_RS02540	COG2226	methyltransferase
LEP3755_RS02570	COG2205	protein histidine kinase activity
LEP3755_RS02625	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LEP3755_RS02630	COG0673	inositol 2-dehydrogenase activity
LEP3755_RS02640	COG1045	serine acetyltransferase
LEP3755_RS02655	COG0489	protein tyrosine kinase activity
LEP3755_RS02680	COG2205	protein histidine kinase activity
LEP3755_RS02680	COG2202	Pas domain
LEP3755_RS02690	COG1132	(ABC) transporter
LEP3755_RS02700	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LEP3755_RS02715	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
LEP3755_RS02730	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
LEP3755_RS02750	COG1696	Membrane protein involved in D-alanine export
LEP3755_RS02755	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
LEP3755_RS02755	COG0662	Cupin 2, conserved barrel domain protein
LEP3755_RS02760	COG0220	tRNA (guanine-N7-)-methyltransferase activity
LEP3755_RS02775	COG1606	tRNA processing
LEP3755_RS02790	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
LEP3755_RS02795	COG4310	Domain of unknown function (DUF2172)
LEP3755_RS02805	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
LEP3755_RS02825	COG0483	inositol monophosphate 1-phosphatase activity
LEP3755_RS02845	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
LEP3755_RS02855	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
LEP3755_RS02865	COG0640	Transcriptional regulator
LEP3755_RS02875	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
LEP3755_RS02880	COG0745	RESPONSE REGULATOR receiver
LEP3755_RS02905	COG0438	transferase activity, transferring glycosyl groups
LEP3755_RS02915	COG0484	heat shock protein binding
LEP3755_RS02955	COG2264	protein methyltransferase activity
LEP3755_RS02960	COG0531	amino acid
LEP3755_RS02970	COG0735	belongs to the Fur family
LEP3755_RS02975	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LEP3755_RS02985	COG1426	Protein conserved in bacteria
LEP3755_RS02990	COG1187	pseudouridine synthase activity
LEP3755_RS02995	COG5002	protein histidine kinase activity
LEP3755_RS03000	COG0745	RESPONSE REGULATOR receiver
LEP3755_RS03010	COG0484	heat shock protein binding
LEP3755_RS03015	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
LEP3755_RS03020	COG2197	response regulator
LEP3755_RS03025	COG3903	Transcriptional regulator
LEP3755_RS03025	COG2319	Wd-40 repeat
LEP3755_RS03030	COG5002	protein histidine kinase activity
LEP3755_RS03065	COG0527	aspartate kinase activity
LEP3755_RS03075	COG2066	Belongs to the glutaminase family
LEP3755_RS03085	COG0435	Glutathione S-transferase
LEP3755_RS03090	COG1285	pathogenesis
LEP3755_RS03120	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LEP3755_RS03130	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
LEP3755_RS03135	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
LEP3755_RS03160	COG0316	Belongs to the HesB IscA family
LEP3755_RS03180	COG0277	FAD linked oxidase domain protein
LEP3755_RS03210	COG1127	ABC transporter
LEP3755_RS03225	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LEP3755_RS03265	COG0837	glucose binding
LEP3755_RS03270	COG0259	pyridoxamine-phosphate oxidase activity
LEP3755_RS03320	COG3629	intracellular signal transduction
LEP3755_RS03320	COG3903	Transcriptional regulator
LEP3755_RS03330	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
LEP3755_RS03335	COG0697	spore germination
LEP3755_RS03340	COG0784	Response regulator, receiver
LEP3755_RS03340	COG2205	protein histidine kinase activity
LEP3755_RS03340	COG5002	protein histidine kinase activity
LEP3755_RS03350	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LEP3755_RS03360	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
LEP3755_RS03365	COG2911	Protein conserved in bacteria
LEP3755_RS03365	COG1361	Conserved repeat domain
LEP3755_RS03365	COG3266	domain, Protein
LEP3755_RS03385	COG0483	inositol monophosphate 1-phosphatase activity
LEP3755_RS03390	COG1480	7TM receptor with intracellular HD hydrolase
LEP3755_RS03395	COG0515	serine threonine protein kinase
LEP3755_RS03395	COG3266	domain, Protein
LEP3755_RS03405	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
LEP3755_RS03420	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LEP3755_RS03435	COG1595	DNA-templated transcription, initiation
LEP3755_RS03445	COG0497	DNA recombination
LEP3755_RS03450	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
LEP3755_RS03465	COG3659	wide pore channel activity
LEP3755_RS03470	COG1959	2 iron, 2 sulfur cluster binding
LEP3755_RS03475	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
LEP3755_RS03480	COG0484	heat shock protein binding
LEP3755_RS03500	COG0114	fumarate hydratase activity
LEP3755_RS03505	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
LEP3755_RS03515	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
LEP3755_RS03540	COG1136	(ABC) transporter
LEP3755_RS03545	COG0577	efflux transmembrane transporter activity
LEP3755_RS03545	COG1136	(ABC) transporter
LEP3755_RS03560	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
LEP3755_RS03570	COG0489	protein tyrosine kinase activity
LEP3755_RS03580	COG2244	polysaccharide biosynthetic process
LEP3755_RS03590	COG1216	Glycosyl transferase, family 2
LEP3755_RS03595	COG0438	transferase activity, transferring glycosyl groups
LEP3755_RS03600	COG1215	transferase activity, transferring glycosyl groups
LEP3755_RS03605	COG0297	glycogen (starch) synthase activity
LEP3755_RS03615	COG2382	esterase
LEP3755_RS03615	COG3507	Belongs to the glycosyl hydrolase 43 family
LEP3755_RS03615	COG3693	PFAM glycoside hydrolase, family 10
LEP3755_RS03625	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
LEP3755_RS03660	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
LEP3755_RS03665	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
LEP3755_RS03715	COG2205	protein histidine kinase activity
LEP3755_RS03715	COG0784	Response regulator, receiver
LEP3755_RS03715	COG2198	Histidine kinase
LEP3755_RS03715	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LEP3755_RS03720	COG2205	protein histidine kinase activity
LEP3755_RS03720	COG0784	Response regulator, receiver
LEP3755_RS03740	COG2202	Pas domain
LEP3755_RS03740	COG2205	protein histidine kinase activity
LEP3755_RS03750	COG0784	Response regulator, receiver
LEP3755_RS03750	COG2205	protein histidine kinase activity
LEP3755_RS03880	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LEP3755_RS03890	COG0037	tRNA processing
LEP3755_RS03900	COG0784	Response regulator, receiver
LEP3755_RS03920	COG0840	transmembrane signaling receptor activity
LEP3755_RS03925	COG2198	Histidine kinase
LEP3755_RS03925	COG0784	Response regulator, receiver
LEP3755_RS03925	COG0643	Histidine kinase
LEP3755_RS03925	COG2198	Histidine kinase
LEP3755_RS03925	COG0784	Response regulator, receiver
LEP3755_RS03925	COG0643	Histidine kinase
LEP3755_RS03925	COG0784	Response regulator, receiver
LEP3755_RS03925	COG2198	Histidine kinase
LEP3755_RS03925	COG0643	Histidine kinase
LEP3755_RS03930	COG0438	transferase activity, transferring glycosyl groups
LEP3755_RS03945	COG0514	ATP-dependent DNA helicase (RecQ)
LEP3755_RS03955	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
LEP3755_RS03960	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
LEP3755_RS03965	COG1494	fructose-1,6-bisphosphatase
LEP3755_RS03970	COG0784	Response regulator, receiver
LEP3755_RS03970	COG2205	protein histidine kinase activity
LEP3755_RS04000	COG0006	proline dipeptidase activity
LEP3755_RS04020	COG0667	Aldo Keto reductase
LEP3755_RS04025	COG0784	Response regulator, receiver
LEP3755_RS04025	COG2198	Histidine kinase
LEP3755_RS04025	COG5002	protein histidine kinase activity
LEP3755_RS04035	COG0745	RESPONSE REGULATOR receiver
LEP3755_RS04045	COG2198	Histidine kinase
LEP3755_RS04045	COG0643	Histidine kinase
LEP3755_RS04050	COG0835	chemotaxis
LEP3755_RS04060	COG2201	protein-glutamate methylesterase activity
LEP3755_RS04065	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
LEP3755_RS04075	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LEP3755_RS04085	COG0004	ammonium transporteR
LEP3755_RS04090	COG0004	ammonium transporteR
LEP3755_RS04135	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
LEP3755_RS04140	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LEP3755_RS04145	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LEP3755_RS04150	COG2048	Heterodisulfide reductase, subunit B
LEP3755_RS04155	COG0515	serine threonine protein kinase
LEP3755_RS04165	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
LEP3755_RS04195	COG0857	belongs to the CobB CobQ family
LEP3755_RS04205	COG0237	dephospho-CoA kinase activity
LEP3755_RS04205	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
LEP3755_RS04245	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LEP3755_RS04255	COG3266	domain, Protein
LEP3755_RS04255	COG0515	serine threonine protein kinase
LEP3755_RS04295	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LEP3755_RS04315	COG1793	dna ligase
LEP3755_RS04330	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LEP3755_RS04340	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LEP3755_RS04345	COG0113	porphobilinogen synthase activity
LEP3755_RS04360	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
LEP3755_RS04375	COG0579	oxidoreductase
LEP3755_RS04390	COG3185	4-Hydroxyphenylpyruvate dioxygenase
LEP3755_RS04400	COG2226	methyltransferase
LEP3755_RS04405	COG0306	phosphate transporter
LEP3755_RS04415	COG1215	transferase activity, transferring glycosyl groups
LEP3755_RS04430	COG0346	lactoylglutathione lyase activity
LEP3755_RS04435	COG3659	wide pore channel activity
LEP3755_RS04445	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LEP3755_RS04450	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
LEP3755_RS04455	COG0284	orotidine-5'-phosphate decarboxylase activity
LEP3755_RS04465	COG2223	nitrite transmembrane transporter activity
LEP3755_RS04470	COG3263	regulation of cellular component size
LEP3755_RS04510	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LEP3755_RS04520	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LEP3755_RS04555	COG4585	Histidine kinase
LEP3755_RS04560	COG2197	response regulator
LEP3755_RS04565	COG2814	Major facilitator Superfamily
LEP3755_RS04580	COG0515	serine threonine protein kinase
LEP3755_RS04580	COG2815	serine threonine protein kinase
LEP3755_RS04595	COG3852	Histidine kinase
LEP3755_RS04615	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LEP3755_RS04620	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LEP3755_RS04625	COG5002	protein histidine kinase activity
LEP3755_RS04625	COG3850	Histidine kinase
LEP3755_RS04640	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LEP3755_RS04660	COG1012	belongs to the aldehyde dehydrogenase family
LEP3755_RS04675	COG0515	serine threonine protein kinase
LEP3755_RS04680	COG2319	Wd-40 repeat
LEP3755_RS04680	COG3903	Transcriptional regulator
LEP3755_RS04690	COG0435	Glutathione S-transferase
LEP3755_RS04720	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LEP3755_RS04735	COG0505	Belongs to the CarA family
LEP3755_RS04745	COG0463	Glycosyl transferase, family 2
LEP3755_RS04775	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
LEP3755_RS04780	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LEP3755_RS04785	COG3852	Histidine kinase
LEP3755_RS04800	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LEP3755_RS04805	COG0110	maltose O-acetyltransferase activity
LEP3755_RS04815	COG0297	glycogen (starch) synthase activity
LEP3755_RS04825	COG2084	Dehydrogenase
LEP3755_RS04840	COG0440	acetolactate synthase activity
LEP3755_RS04860	COG2814	Major facilitator Superfamily
LEP3755_RS04865	COG3409	Peptidoglycan-binding domain 1 protein
LEP3755_RS04865	COG3773	Cell wall hydrolase
LEP3755_RS04870	COG0515	serine threonine protein kinase
LEP3755_RS04870	COG3064	Membrane
LEP3755_RS04870	COG4991	sh3 domain protein
LEP3755_RS04880	COG0521	Mo-molybdopterin cofactor biosynthetic process
LEP3755_RS04890	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
LEP3755_RS04910	COG5002	protein histidine kinase activity
LEP3755_RS04915	COG2203	Gaf domain
LEP3755_RS04915	COG0840	transmembrane signaling receptor activity
LEP3755_RS04920	COG0784	Response regulator, receiver
LEP3755_RS04920	COG2198	Histidine kinase
LEP3755_RS04920	COG0643	Histidine kinase
LEP3755_RS04925	COG2203	Gaf domain
LEP3755_RS04925	COG0840	transmembrane signaling receptor activity
LEP3755_RS04940	COG0784	Response regulator, receiver
LEP3755_RS04950	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
LEP3755_RS04960	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
LEP3755_RS04965	COG0131	Imidazoleglycerol-phosphate dehydratase
LEP3755_RS04990	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
LEP3755_RS05000	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LEP3755_RS05000	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LEP3755_RS05010	COG1515	deoxyribonuclease V activity
LEP3755_RS05025	COG3541	Predicted nucleotidyltransferase
LEP3755_RS05060	COG1672	PFAM Archaeal ATPase
LEP3755_RS05060	COG2319	Wd-40 repeat
LEP3755_RS05105	COG3659	wide pore channel activity
LEP3755_RS05155	COG2252	PERMEase
LEP3755_RS05195	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LEP3755_RS05210	COG2027	D-alanyl-D-alanine carboxypeptidase
LEP3755_RS05215	COG5002	protein histidine kinase activity
LEP3755_RS05215	COG0784	Response regulator, receiver
LEP3755_RS05215	COG2205	protein histidine kinase activity
LEP3755_RS05245	COG0601	transmembrane transport
LEP3755_RS05250	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LEP3755_RS05305	COG0840	transmembrane signaling receptor activity
LEP3755_RS05305	COG2203	Gaf domain
LEP3755_RS05310	COG2319	Wd-40 repeat
LEP3755_RS05310	COG1672	PFAM Archaeal ATPase
LEP3755_RS05330	COG2205	protein histidine kinase activity
LEP3755_RS05330	COG2198	Histidine kinase
LEP3755_RS05330	COG0784	Response regulator, receiver
LEP3755_RS05375	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LEP3755_RS05385	COG0668	transmembrane transport
LEP3755_RS05395	COG2912	Transglutaminase-like superfamily
LEP3755_RS05405	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LEP3755_RS05410	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LEP3755_RS05445	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
LEP3755_RS05445	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
LEP3755_RS05460	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
LEP3755_RS05475	COG1408	metallophosphoesterase
LEP3755_RS05480	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LEP3755_RS05485	COG0398	Pfam SNARE associated Golgi protein
LEP3755_RS05490	COG5398	heme oxygenase
LEP3755_RS05505	COG2226	methyltransferase
LEP3755_RS05510	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
LEP3755_RS05515	COG0805	protein transport
LEP3755_RS05535	COG1981	membrane
LEP3755_RS05550	COG1492	cobalamin metabolic process
LEP3755_RS05595	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LEP3755_RS05610	COG0367	asparagine synthase
LEP3755_RS05615	COG1404	Belongs to the peptidase S8 family
LEP3755_RS05615	COG4935	Belongs to the peptidase S8 family
LEP3755_RS05625	COG1662	PFAM IS1 transposase
LEP3755_RS05635	COG1079	Belongs to the binding-protein-dependent transport system permease family
LEP3755_RS05710	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
LEP3755_RS05720	COG2183	response to ionizing radiation
LEP3755_RS05735	COG0017	Asparaginyl-tRNA synthetase
LEP3755_RS05765	COG0006	proline dipeptidase activity
LEP3755_RS05780	COG1116	anion transmembrane transporter activity
LEP3755_RS05790	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
LEP3755_RS05795	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
LEP3755_RS05820	COG5002	protein histidine kinase activity
LEP3755_RS05820	COG0784	Response regulator, receiver
LEP3755_RS05835	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LEP3755_RS05850	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
LEP3755_RS05855	COG0784	Response regulator, receiver
LEP3755_RS05855	COG2205	protein histidine kinase activity
LEP3755_RS05885	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
LEP3755_RS05890	COG1160	GTP binding
LEP3755_RS05930	COG1216	Glycosyl transferase, family 2
LEP3755_RS05930	COG0463	Glycosyl transferase, family 2
LEP3755_RS05935	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LEP3755_RS05950	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
LEP3755_RS05960	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
LEP3755_RS06060	COG0484	heat shock protein binding
LEP3755_RS06100	COG0366	Alpha amylase catalytic
LEP3755_RS06105	COG1640	4-alpha-glucanotransferase
LEP3755_RS06115	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
LEP3755_RS06115	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
LEP3755_RS06150	COG1376	ErfK ybiS ycfS ynhG family protein
LEP3755_RS06155	COG0443	Heat shock 70 kDa protein
LEP3755_RS06160	COG0484	heat shock protein binding
LEP3755_RS06180	COG2267	carboxylic ester hydrolase activity
LEP3755_RS06190	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LEP3755_RS06195	COG0577	efflux transmembrane transporter activity
LEP3755_RS06195	COG1136	(ABC) transporter
LEP3755_RS06200	COG1136	(ABC) transporter
LEP3755_RS06210	COG0681	Belongs to the peptidase S26 family
LEP3755_RS06220	COG1970	mechanosensitive ion channel activity
LEP3755_RS06225	COG0542	response to heat
LEP3755_RS06245	COG0484	heat shock protein binding
LEP3755_RS06260	COG0019	diaminopimelate decarboxylase activity
LEP3755_RS06265	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
LEP3755_RS06270	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
LEP3755_RS06285	COG0484	heat shock protein binding
LEP3755_RS06290	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LEP3755_RS06295	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
LEP3755_RS06300	COG0384	phenazine biosynthesis protein PhzF
LEP3755_RS06305	COG2234	aminopeptidase activity
LEP3755_RS06330	COG1253	flavin adenine dinucleotide binding
LEP3755_RS06335	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
LEP3755_RS06380	COG1404	Belongs to the peptidase S8 family
LEP3755_RS06395	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
LEP3755_RS06405	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LEP3755_RS06405	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LEP3755_RS06410	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
LEP3755_RS06415	COG0509	glycine decarboxylation via glycine cleavage system
LEP3755_RS06420	COG0404	The glycine cleavage system catalyzes the degradation of glycine
LEP3755_RS06425	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
LEP3755_RS06435	COG1192	Involved in chromosome partitioning
LEP3755_RS06455	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
LEP3755_RS06470	COG3266	domain, Protein
LEP3755_RS06470	COG0515	serine threonine protein kinase
LEP3755_RS06480	COG2205	protein histidine kinase activity
LEP3755_RS06480	COG0784	Response regulator, receiver
LEP3755_RS06495	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LEP3755_RS06520	COG3536	Protein conserved in bacteria
LEP3755_RS06545	COG0138	bifunctional purine biosynthesis protein purh
LEP3755_RS06570	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
LEP3755_RS06600	COG0459	protein refolding
LEP3755_RS06605	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
LEP3755_RS06610	COG0653	protein targeting
LEP3755_RS06615	COG3153	acetyltransferase
LEP3755_RS06620	COG0563	adenylate kinase activity
LEP3755_RS06625	COG0201	protein transport
LEP3755_RS06655	COG0163	prenyltransferase activity
LEP3755_RS06660	COG0557	exoribonuclease II activity
LEP3755_RS06675	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
LEP3755_RS06675	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LEP3755_RS06695	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
LEP3755_RS06700	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
LEP3755_RS06705	COG2205	protein histidine kinase activity
LEP3755_RS06710	COG1333	cytochrome c biogenesis protein
LEP3755_RS06715	COG4232	protein-disulfide reductase activity
LEP3755_RS06735	COG0772	Belongs to the SEDS family
LEP3755_RS06745	COG1063	alcohol dehydrogenase
LEP3755_RS06750	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
LEP3755_RS06765	COG3443	Belongs to the bacterial solute-binding protein 9 family
LEP3755_RS06765	COG0803	Belongs to the bacterial solute-binding protein 9 family
LEP3755_RS06775	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LEP3755_RS06785	COG0438	transferase activity, transferring glycosyl groups
LEP3755_RS06795	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
LEP3755_RS06800	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LEP3755_RS06815	COG1028	Short-chain dehydrogenase reductase Sdr
LEP3755_RS06835	COG2885	chlorophyll binding
LEP3755_RS06890	COG1216	Glycosyl transferase, family 2
LEP3755_RS06890	COG1442	glycosyl transferase family 8
LEP3755_RS06895	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
LEP3755_RS06915	COG1672	PFAM Archaeal ATPase
LEP3755_RS06920	COG0828	Belongs to the bacterial ribosomal protein bS21 family
LEP3755_RS06935	COG2259	Doxx family
LEP3755_RS06980	COG0628	permease
LEP3755_RS07035	COG5002	protein histidine kinase activity
LEP3755_RS07050	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
LEP3755_RS07050	COG3264	Mechanosensitive ion channel
LEP3755_RS07070	COG0366	Alpha amylase catalytic
LEP3755_RS07085	COG0745	RESPONSE REGULATOR receiver
LEP3755_RS07090	COG5002	protein histidine kinase activity
LEP3755_RS07115	COG1196	nuclear chromosome segregation
LEP3755_RS07115	COG0739	heme binding
LEP3755_RS07115	COG0741	lytic transglycosylase activity
LEP3755_RS07130	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LEP3755_RS07135	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LEP3755_RS07145	COG0556	nucleotide-excision repair
LEP3755_RS07155	COG2119	membrane
LEP3755_RS07160	COG2119	membrane
LEP3755_RS07185	COG0493	'glutamate synthase
LEP3755_RS07190	COG0070	glutamate synthase
LEP3755_RS07190	COG0069	glutamate synthase activity
LEP3755_RS07190	COG0067	glutamate synthase
LEP3755_RS07225	COG1662	PFAM IS1 transposase
LEP3755_RS07260	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
LEP3755_RS07280	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
LEP3755_RS07310	COG1253	flavin adenine dinucleotide binding
LEP3755_RS07315	COG0354	folic acid binding
LEP3755_RS07325	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
LEP3755_RS07330	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LEP3755_RS07335	COG0552	protein localization to endoplasmic reticulum
LEP3755_RS07350	COG3239	Fatty acid desaturase
LEP3755_RS07360	COG0237	dephospho-CoA kinase activity
LEP3755_RS07390	COG0616	signal peptide processing
LEP3755_RS07400	COG2217	Heavy metal translocating P-type atpase
LEP3755_RS07420	COG3292	Two component regulator propeller
LEP3755_RS07420	COG0745	RESPONSE REGULATOR receiver
LEP3755_RS07420	COG2205	protein histidine kinase activity
LEP3755_RS07425	COG0788	formyltetrahydrofolate deformylase activity
LEP3755_RS07455	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LEP3755_RS07465	COG2197	response regulator
LEP3755_RS07470	COG1035	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus
LEP3755_RS07475	COG0583	DNA-binding transcription factor activity
LEP3755_RS07480	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
LEP3755_RS07490	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LEP3755_RS07495	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
LEP3755_RS07510	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LEP3755_RS07515	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
LEP3755_RS07520	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
LEP3755_RS07525	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
LEP3755_RS07530	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
LEP3755_RS07535	COG4451	ribulose bisphosphate carboxylase, small
LEP3755_RS07535	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
LEP3755_RS07540	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
LEP3755_RS07575	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
LEP3755_RS07575	COG0392	lysyltransferase activity
LEP3755_RS07605	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LEP3755_RS07610	COG1587	Uroporphyrinogen-III synthase
LEP3755_RS07615	COG2124	cytochrome p450
LEP3755_RS07620	COG0110	maltose O-acetyltransferase activity
LEP3755_RS07630	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
LEP3755_RS07635	COG2264	protein methyltransferase activity
LEP3755_RS07640	COG0531	amino acid
LEP3755_RS07655	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
LEP3755_RS07675	COG1672	PFAM Archaeal ATPase
LEP3755_RS07675	COG2319	Wd-40 repeat
LEP3755_RS07680	COG0438	transferase activity, transferring glycosyl groups
LEP3755_RS07700	COG5001	Diguanylate cyclase
LEP3755_RS07700	COG3706	GGDEF domain
LEP3755_RS07700	COG2203	Gaf domain
LEP3755_RS07700	COG4251	negative regulation of phosphorylation
LEP3755_RS07730	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
LEP3755_RS07745	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LEP3755_RS07755	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
LEP3755_RS07760	COG1842	Phage shock protein A
LEP3755_RS07775	COG1262	PFAM Formylglycine-generating sulfatase enzyme
LEP3755_RS07780	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
LEP3755_RS07785	COG0739	heme binding
LEP3755_RS07785	COG0741	lytic transglycosylase activity
LEP3755_RS07785	COG1196	nuclear chromosome segregation
LEP3755_RS07790	COG1741	Belongs to the pirin family
LEP3755_RS07795	COG2197	response regulator
LEP3755_RS07815	COG3659	wide pore channel activity
LEP3755_RS07830	COG1136	(ABC) transporter
LEP3755_RS07850	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LEP3755_RS07880	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
LEP3755_RS07885	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
LEP3755_RS07895	COG0617	tRNA 3'-terminal CCA addition
LEP3755_RS07895	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
LEP3755_RS07895	COG0517	IMP dehydrogenase activity
LEP3755_RS07900	COG0140	phosphoribosyl-ATP diphosphatase activity
LEP3755_RS07900	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
LEP3755_RS07910	COG0784	Response regulator, receiver
LEP3755_RS07910	COG5002	protein histidine kinase activity
LEP3755_RS07910	COG2198	Histidine kinase
LEP3755_RS07930	COG0436	Aminotransferase
LEP3755_RS07935	COG4451	ribulose bisphosphate carboxylase, small
LEP3755_RS07935	COG0464	growth
LEP3755_RS07945	COG0107	imidazoleglycerol-phosphate synthase activity
LEP3755_RS07970	COG1396	sequence-specific DNA binding
LEP3755_RS07985	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LEP3755_RS07995	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LEP3755_RS08015	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
LEP3755_RS08020	COG2211	Major facilitator Superfamily
LEP3755_RS08035	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LEP3755_RS08070	COG1846	Transcriptional regulator
LEP3755_RS08075	COG0395	ABC-type sugar transport system, permease component
LEP3755_RS08100	COG2319	Wd-40 repeat
LEP3755_RS08100	COG4249	Peptidase C14 caspase catalytic subunit p20
LEP3755_RS08120	COG2801	Transposase and inactivated derivatives
LEP3755_RS08125	COG2814	Major facilitator Superfamily
LEP3755_RS08140	COG0519	Catalyzes the synthesis of GMP from XMP
LEP3755_RS08140	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LEP3755_RS08145	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
LEP3755_RS08150	COG0328	RNA-DNA hybrid ribonuclease activity
LEP3755_RS08180	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
LEP3755_RS08190	COG4802	Ferredoxin thioredoxin reductase catalytic beta chain
LEP3755_RS08195	COG0719	Fe-S assembly protein
LEP3755_RS08205	COG0396	ATPase activity
LEP3755_RS08210	COG0719	Fe-S assembly protein
LEP3755_RS08215	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
LEP3755_RS08225	COG0793	Belongs to the peptidase S41A family
LEP3755_RS08230	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LEP3755_RS08235	COG2146	nitrite reductase [NAD(P)H] activity
LEP3755_RS08250	COG5002	protein histidine kinase activity
LEP3755_RS08255	COG3903	Transcriptional regulator
LEP3755_RS08255	COG3629	intracellular signal transduction
LEP3755_RS08280	COG3903	Transcriptional regulator
LEP3755_RS08280	COG3629	intracellular signal transduction
LEP3755_RS08285	COG4636	protein conserved in cyanobacteria
LEP3755_RS08290	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
LEP3755_RS08295	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
LEP3755_RS08300	COG0793	Belongs to the peptidase S41A family
LEP3755_RS08305	COG1078	dGTPase activity
LEP3755_RS08310	COG1126	abc transporter atp-binding protein
LEP3755_RS08315	COG0765	amino acid transport
LEP3755_RS08320	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LEP3755_RS08325	COG3659	wide pore channel activity
LEP3755_RS08330	COG1803	Methylglyoxal synthase
LEP3755_RS08330	COG1597	lipid kinase activity
LEP3755_RS08335	COG0672	)-iron permease
LEP3755_RS08370	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
LEP3755_RS08375	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
LEP3755_RS08380	COG1131	(ABC) transporter
LEP3755_RS08385	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
LEP3755_RS08395	COG2205	protein histidine kinase activity
LEP3755_RS08395	COG5002	protein histidine kinase activity
LEP3755_RS08395	COG0784	Response regulator, receiver
LEP3755_RS08415	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
LEP3755_RS08430	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LEP3755_RS08435	COG0768	penicillin binding
LEP3755_RS08450	COG0167	dihydroorotate dehydrogenase activity
LEP3755_RS08460	COG0529	Catalyzes the synthesis of activated sulfate
LEP3755_RS08470	COG5002	protein histidine kinase activity
LEP3755_RS08470	COG2205	protein histidine kinase activity
LEP3755_RS08470	COG0784	Response regulator, receiver
LEP3755_RS08515	COG0575	Belongs to the CDS family
LEP3755_RS08525	COG1982	Orn Lys Arg decarboxylase major
LEP3755_RS08530	COG0012	GTP binding
LEP3755_RS08535	COG0003	Pfam Anion-transporting ATPase
LEP3755_RS08540	COG0515	serine threonine protein kinase
LEP3755_RS08540	COG3064	Membrane
LEP3755_RS08540	COG4991	sh3 domain protein
LEP3755_RS08570	COG0804	urea catabolic process
LEP3755_RS08585	COG3411	Ferredoxin
LEP3755_RS08590	COG2197	response regulator
LEP3755_RS08605	COG0322	excinuclease ABC activity
LEP3755_RS08620	COG0475	glutathione-regulated potassium exporter activity
LEP3755_RS08620	COG0589	response to stress
LEP3755_RS08635	COG0772	Belongs to the SEDS family
LEP3755_RS08640	COG0489	protein tyrosine kinase activity
LEP3755_RS08650	COG0408	coproporphyrinogen oxidase activity
LEP3755_RS08665	COG0740	serine-type endopeptidase activity
LEP3755_RS08670	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
LEP3755_RS08680	COG3659	wide pore channel activity
LEP3755_RS08685	COG1331	Highly conserved protein containing a thioredoxin domain
LEP3755_RS08700	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
LEP3755_RS08710	COG1361	Conserved repeat domain
LEP3755_RS08750	COG0058	SHG alpha-glucan phosphorylase activity
LEP3755_RS08755	COG0406	alpha-ribazole phosphatase activity
LEP3755_RS08770	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LEP3755_RS08775	COG1937	Protein conserved in bacteria
LEP3755_RS08780	COG0702	epimerase
LEP3755_RS08795	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LEP3755_RS08805	COG4251	negative regulation of phosphorylation
LEP3755_RS08805	COG3706	GGDEF domain
LEP3755_RS08805	COG5001	Diguanylate cyclase
LEP3755_RS08805	COG2203	Gaf domain
LEP3755_RS08815	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LEP3755_RS08830	COG2022	thiamine diphosphate biosynthetic process
LEP3755_RS08830	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LEP3755_RS08850	COG2022	thiamine diphosphate biosynthetic process
LEP3755_RS08875	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
LEP3755_RS08895	COG0745	RESPONSE REGULATOR receiver
LEP3755_RS08905	COG0432	Pfam Uncharacterised protein family UPF0047
LEP3755_RS08955	COG3854	ATPases associated with a variety of cellular activities
LEP3755_RS08960	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LEP3755_RS08965	COG1215	transferase activity, transferring glycosyl groups
LEP3755_RS08970	COG0542	response to heat
LEP3755_RS08975	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LEP3755_RS08980	COG2202	Pas domain
LEP3755_RS08980	COG2205	protein histidine kinase activity
LEP3755_RS08985	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
LEP3755_RS08990	COG0515	serine threonine protein kinase
LEP3755_RS08990	COG1357	PFAM Pentapeptide repeats (8 copies)
LEP3755_RS09025	COG1858	cytochrome C peroxidase
LEP3755_RS09035	COG2198	Histidine kinase
LEP3755_RS09035	COG0643	Histidine kinase
LEP3755_RS09035	COG0784	Response regulator, receiver
LEP3755_RS09040	COG2203	Gaf domain
LEP3755_RS09040	COG0840	transmembrane signaling receptor activity
LEP3755_RS09055	COG0784	Response regulator, receiver
LEP3755_RS09060	COG0318	PFAM AMP-dependent synthetase and ligase
LEP3755_RS09065	COG4636	protein conserved in cyanobacteria
LEP3755_RS09080	COG1410	methionine synthase
LEP3755_RS09080	COG0646	methionine synthase
LEP3755_RS09115	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LEP3755_RS09120	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LEP3755_RS09120	COG1116	anion transmembrane transporter activity
LEP3755_RS09125	COG1116	anion transmembrane transporter activity
LEP3755_RS09130	COG0716	FMN binding
LEP3755_RS09135	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
LEP3755_RS09165	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
LEP3755_RS09165	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
LEP3755_RS09170	COG0501	Belongs to the peptidase M48B family
LEP3755_RS09245	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LEP3755_RS09260	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
LEP3755_RS09280	COG1968	undecaprenyl-diphosphatase activity
LEP3755_RS09295	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
LEP3755_RS09305	COG5002	protein histidine kinase activity
LEP3755_RS09315	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
LEP3755_RS09325	COG0438	transferase activity, transferring glycosyl groups
LEP3755_RS09330	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
LEP3755_RS09330	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
LEP3755_RS09340	COG1176	ABC-type spermidine putrescine transport system, permease component I
LEP3755_RS09345	COG1177	transmembrane transport
LEP3755_RS09370	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LEP3755_RS09380	COG1216	Glycosyl transferase, family 2
LEP3755_RS09385	COG0110	maltose O-acetyltransferase activity
LEP3755_RS09405	COG0463	Glycosyl transferase, family 2
LEP3755_RS09415	COG0438	transferase activity, transferring glycosyl groups
LEP3755_RS09420	COG0438	transferase activity, transferring glycosyl groups
LEP3755_RS09450	COG1216	Glycosyl transferase, family 2
LEP3755_RS09470	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
LEP3755_RS09475	COG2877	3-deoxy-8-phosphooctulonate synthase activity
LEP3755_RS09485	COG1696	Membrane protein involved in D-alanine export
LEP3755_RS09490	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
LEP3755_RS09495	COG0517	IMP dehydrogenase activity
LEP3755_RS09495	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
LEP3755_RS09525	COG0745	RESPONSE REGULATOR receiver
LEP3755_RS09530	COG1216	Glycosyl transferase, family 2
LEP3755_RS09550	COG1215	transferase activity, transferring glycosyl groups
LEP3755_RS09580	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LEP3755_RS09585	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LEP3755_RS09590	COG1994	Peptidase M50
LEP3755_RS09590	COG0517	IMP dehydrogenase activity
LEP3755_RS09595	COG0628	permease
LEP3755_RS09620	COG0515	serine threonine protein kinase
LEP3755_RS09655	COG0261	This protein binds to 23S rRNA in the presence of protein L20
LEP3755_RS09660	COG0211	Belongs to the bacterial ribosomal protein bL27 family
LEP3755_RS09670	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
LEP3755_RS09675	COG3240	lipase activity
LEP3755_RS09680	COG0604	alcohol dehydrogenase
LEP3755_RS09685	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LEP3755_RS09685	COG0475	glutathione-regulated potassium exporter activity
LEP3755_RS09690	COG2205	protein histidine kinase activity
LEP3755_RS09700	COG0312	modulator of DNA gyrase
LEP3755_RS09705	COG0589	response to stress
LEP3755_RS09710	COG0824	Thioesterase
LEP3755_RS09795	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
LEP3755_RS09800	COG1028	Short-chain dehydrogenase reductase Sdr
LEP3755_RS09805	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LEP3755_RS09815	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LEP3755_RS09830	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
LEP3755_RS09835	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
LEP3755_RS09840	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
LEP3755_RS09870	COG3852	Histidine kinase
LEP3755_RS09880	COG0288	reversible hydration of carbon dioxide
LEP3755_RS09885	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LEP3755_RS09890	COG0010	Belongs to the arginase family
LEP3755_RS09900	COG0495	leucyl-tRNA aminoacylation
LEP3755_RS09905	COG2911	Protein conserved in bacteria
LEP3755_RS09905	COG3266	domain, Protein
LEP3755_RS09905	COG1361	Conserved repeat domain
LEP3755_RS09910	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LEP3755_RS09915	COG1403	HNH endonuclease
LEP3755_RS09960	COG0723	plastoquinol--plastocyanin reductase activity
LEP3755_RS09970	COG3237	CsbD-like
LEP3755_RS09975	COG0556	nucleotide-excision repair
LEP3755_RS09980	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
LEP3755_RS10005	COG0459	protein refolding
LEP3755_RS10030	COG3118	belongs to the thioredoxin family
LEP3755_RS10035	COG0436	Aminotransferase
LEP3755_RS10055	COG1216	Glycosyl transferase, family 2
LEP3755_RS10080	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LEP3755_RS10095	COG0438	transferase activity, transferring glycosyl groups
LEP3755_RS10100	COG0438	transferase activity, transferring glycosyl groups
LEP3755_RS10130	COG0438	transferase activity, transferring glycosyl groups
LEP3755_RS10135	COG0438	transferase activity, transferring glycosyl groups
LEP3755_RS10165	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LEP3755_RS10170	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
LEP3755_RS10190	COG3937	granule-associated protein
LEP3755_RS10235	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LEP3755_RS10250	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
LEP3755_RS10255	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LEP3755_RS10260	COG0812	UDP-N-acetylmuramate dehydrogenase activity
LEP3755_RS10265	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
LEP3755_RS10290	COG0747	negative chemotaxis
LEP3755_RS10300	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LEP3755_RS10305	COG0166	Belongs to the GPI family
LEP3755_RS10350	COG1473	amidohydrolase
LEP3755_RS10375	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
LEP3755_RS10380	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
LEP3755_RS10405	COG3659	wide pore channel activity
LEP3755_RS10410	COG0501	Belongs to the peptidase M48B family
LEP3755_RS10445	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
LEP3755_RS10450	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
LEP3755_RS10475	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
LEP3755_RS10480	COG0842	Transport permease protein
LEP3755_RS10485	COG0842	Transport permease protein
LEP3755_RS10490	COG1131	(ABC) transporter
LEP3755_RS10515	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LEP3755_RS10520	COG1116	anion transmembrane transporter activity
LEP3755_RS10555	COG3665	Urea carboxylase-associated protein
LEP3755_RS10560	COG3665	Urea carboxylase-associated protein
LEP3755_RS10565	COG0439	Biotin carboxylase
LEP3755_RS10585	COG4178	(ABC) transporter
LEP3755_RS10620	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LEP3755_RS10625	COG5002	protein histidine kinase activity
LEP3755_RS10630	COG0745	RESPONSE REGULATOR receiver
LEP3755_RS10640	COG1131	(ABC) transporter
LEP3755_RS10650	COG0076	glutamate decarboxylase activity
LEP3755_RS10670	COG0571	ribonuclease III activity
LEP3755_RS10680	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
LEP3755_RS10685	COG0830	nickel cation binding
LEP3755_RS10740	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
LEP3755_RS10770	COG2208	phosphoserine phosphatase activity
LEP3755_RS10780	COG2351	hydroxyisourate hydrolase activity
LEP3755_RS10795	COG0196	riboflavin kinase activity
LEP3755_RS10800	COG0714	Associated with various cellular activities
LEP3755_RS10820	COG1217	gtp-binding protein TYPA
LEP3755_RS10830	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
LEP3755_RS10835	COG0484	heat shock protein binding
LEP3755_RS10850	COG0438	transferase activity, transferring glycosyl groups
LEP3755_RS10860	COG0463	Glycosyl transferase, family 2
LEP3755_RS10870	COG1442	glycosyl transferase family 8
LEP3755_RS10885	COG0463	Glycosyl transferase, family 2
LEP3755_RS10890	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
LEP3755_RS10895	COG0268	Binds directly to 16S ribosomal RNA
LEP3755_RS10900	COG0084	hydrolase, TatD family'
LEP3755_RS10905	COG0085	RNA polymerase activity
LEP3755_RS10910	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
LEP3755_RS10915	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
LEP3755_RS10920	COG1442	glycosyl transferase family 8
LEP3755_RS10920	COG1216	Glycosyl transferase, family 2
LEP3755_RS10925	COG2226	methyltransferase
LEP3755_RS10930	COG0825	malonyl-CoA metabolic process
LEP3755_RS10935	COG4221	oxidoreductase activity
LEP3755_RS10940	COG0302	gtp cyclohydrolase
LEP3755_RS10945	COG0135	phosphoribosylanthranilate isomerase activity
LEP3755_RS10975	COG0850	regulation of cytokinetic process
LEP3755_RS10980	COG0438	transferase activity, transferring glycosyl groups
LEP3755_RS10995	COG0739	heme binding
LEP3755_RS11005	COG0445	tRNA wobble uridine modification
LEP3755_RS11010	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LEP3755_RS11020	COG1562	ergosterol biosynthetic process
LEP3755_RS11025	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
LEP3755_RS11025	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LEP3755_RS11030	COG2133	pyrroloquinoline quinone binding
LEP3755_RS11030	COG5183	chlorophyll binding
LEP3755_RS11040	COG2894	cell division
LEP3755_RS11045	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
LEP3755_RS11050	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
LEP3755_RS11055	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
LEP3755_RS11070	COG3845	ABC transporter
LEP3755_RS11090	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
LEP3755_RS11135	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
LEP3755_RS11145	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
LEP3755_RS11160	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
LEP3755_RS11165	COG0737	Belongs to the 5'-nucleotidase family
LEP3755_RS11170	COG4991	sh3 domain protein
LEP3755_RS11170	COG3064	Membrane
LEP3755_RS11170	COG0515	serine threonine protein kinase
LEP3755_RS11175	COG2340	Cysteine-rich secretory protein family
LEP3755_RS11180	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
LEP3755_RS11180	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LEP3755_RS11200	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
LEP3755_RS11205	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LEP3755_RS11225	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
LEP3755_RS11245	COG0525	valine-tRNA ligase activity
LEP3755_RS11255	COG0572	uridine kinase
LEP3755_RS11260	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
LEP3755_RS11290	COG3239	Fatty acid desaturase
LEP3755_RS11320	COG0405	Gamma-glutamyltransferase
LEP3755_RS11325	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
LEP3755_RS11385	COG0372	Belongs to the citrate synthase family
LEP3755_RS11395	COG0402	S-adenosylhomocysteine deaminase activity
LEP3755_RS11405	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
LEP3755_RS11410	COG0488	(ABC) transporter
LEP3755_RS11425	COG0436	Aminotransferase
LEP3755_RS11450	COG1959	2 iron, 2 sulfur cluster binding
LEP3755_RS11460	COG0730	response to heat
LEP3755_RS11465	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
LEP3755_RS11475	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
LEP3755_RS11480	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
LEP3755_RS11485	COG4208	sulfate ABC transporter
LEP3755_RS11495	COG0730	response to heat
LEP3755_RS11500	COG0671	phosphoesterase, PA-phosphatase related
LEP3755_RS11520	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LEP3755_RS11525	COG2873	o-acetylhomoserine
LEP3755_RS11530	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LEP3755_RS11535	COG0121	glutamine amidotransferase
LEP3755_RS11555	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LEP3755_RS11560	COG0395	ABC-type sugar transport system, permease component
LEP3755_RS11565	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
LEP3755_RS11570	COG5322	oxidoreductase activity
LEP3755_RS11605	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
LEP3755_RS11610	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
LEP3755_RS11615	COG0539	negative regulation of cytoplasmic translation
LEP3755_RS11620	COG0412	Dienelactone hydrolase
LEP3755_RS11625	COG1725	Transcriptional regulator
LEP3755_RS11630	COG5592	hemerythrin HHE cation binding domain
LEP3755_RS11640	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LEP3755_RS11650	COG2264	protein methyltransferase activity
LEP3755_RS11655	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LEP3755_RS11690	COG2801	Transposase and inactivated derivatives
LEP3755_RS11890	COG0321	lipoyl(octanoyl) transferase activity
LEP3755_RS11895	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
LEP3755_RS11900	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
LEP3755_RS11910	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
LEP3755_RS11915	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
LEP3755_RS11920	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
LEP3755_RS11930	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LEP3755_RS11935	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
LEP3755_RS11945	COG0515	serine threonine protein kinase
LEP3755_RS11945	COG3266	domain, Protein
LEP3755_RS11955	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
LEP3755_RS11980	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LEP3755_RS12005	COG1215	transferase activity, transferring glycosyl groups
LEP3755_RS12020	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
LEP3755_RS12035	COG0358	DNA primase activity
LEP3755_RS12040	COG2197	response regulator
LEP3755_RS12045	COG4585	Histidine kinase
LEP3755_RS12050	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LEP3755_RS12055	COG0577	efflux transmembrane transporter activity
LEP3755_RS12055	COG1136	(ABC) transporter
LEP3755_RS12060	COG1136	(ABC) transporter
LEP3755_RS12070	COG1064	alcohol dehydrogenase
LEP3755_RS12075	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
LEP3755_RS12090	COG0613	PHP domain protein
LEP3755_RS12115	COG0587	DNA-directed DNA polymerase activity
LEP3755_RS12125	COG0587	DNA-directed DNA polymerase activity
LEP3755_RS12155	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
LEP3755_RS12160	COG1472	Belongs to the glycosyl hydrolase 3 family
LEP3755_RS12200	COG1598	PFAM Uncharacterised protein family UPF0150
LEP3755_RS12235	COG2177	Part of the ABC transporter FtsEX involved in
LEP3755_RS12265	COG1028	Short-chain dehydrogenase reductase Sdr
LEP3755_RS12285	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
LEP3755_RS12290	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
LEP3755_RS12295	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
LEP3755_RS12300	COG0625	glutathione transferase activity
LEP3755_RS12310	COG2885	chlorophyll binding
LEP3755_RS12320	COG0314	molybdopterin synthase activity
LEP3755_RS12325	COG1404	Belongs to the peptidase S8 family
LEP3755_RS12330	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
LEP3755_RS12335	COG2045	Belongs to the ComB family
LEP3755_RS12340	COG0572	uridine kinase
LEP3755_RS12355	COG1846	Transcriptional regulator
LEP3755_RS12360	COG1846	Transcriptional regulator
LEP3755_RS12365	COG2062	phosphohistidine phosphatase, SixA
LEP3755_RS12390	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LEP3755_RS12405	COG1032	radical SAM domain protein
LEP3755_RS12425	COG3956	TIGRFAM MazG family protein
LEP3755_RS12430	COG2119	membrane
LEP3755_RS12450	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
LEP3755_RS12460	COG1366	Belongs to the anti-sigma-factor antagonist family
LEP3755_RS12470	COG1530	ribonuclease E activity
LEP3755_RS12475	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
LEP3755_RS12485	COG0077	Prephenate dehydratase
LEP3755_RS12515	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
LEP3755_RS12520	COG2267	carboxylic ester hydrolase activity
LEP3755_RS12525	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
LEP3755_RS12530	COG0740	serine-type endopeptidase activity
LEP3755_RS12535	COG0544	peptidyl-prolyl cis-trans isomerase activity
LEP3755_RS12540	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
LEP3755_RS12545	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LEP3755_RS12550	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
LEP3755_RS12570	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
LEP3755_RS12585	COG0070	glutamate synthase
LEP3755_RS12585	COG0067	glutamate synthase
LEP3755_RS12585	COG0069	glutamate synthase activity
LEP3755_RS12595	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
LEP3755_RS12595	COG0662	Cupin 2, conserved barrel domain protein
LEP3755_RS12600	COG0316	Belongs to the HesB IscA family
LEP3755_RS12605	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
LEP3755_RS12610	COG0049	tRNA binding
LEP3755_RS12615	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
LEP3755_RS12620	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LEP3755_RS12650	COG0051	transcription antitermination factor activity, RNA binding
LEP3755_RS12655	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
LEP3755_RS12665	COG0557	exoribonuclease II activity
LEP3755_RS12670	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
LEP3755_RS12695	COG0157	Belongs to the NadC ModD family
LEP3755_RS12715	COG1215	transferase activity, transferring glycosyl groups
LEP3755_RS12730	COG0024	Methionine aminopeptidase
LEP3755_RS12755	COG0815	Transfers the fatty acyl group on membrane lipoproteins
LEP3755_RS12760	COG3781	membrane
LEP3755_RS12770	COG0039	L-malate dehydrogenase activity
LEP3755_RS12785	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LEP3755_RS12810	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
LEP3755_RS12820	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
LEP3755_RS12825	COG1215	transferase activity, transferring glycosyl groups
LEP3755_RS12830	COG1215	transferase activity, transferring glycosyl groups
LEP3755_RS12835	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
LEP3755_RS12865	COG0765	amino acid transport
LEP3755_RS12880	COG3596	GTP binding
LEP3755_RS12885	COG0745	RESPONSE REGULATOR receiver
LEP3755_RS12895	COG0052	Belongs to the universal ribosomal protein uS2 family
LEP3755_RS12900	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
LEP3755_RS12910	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
LEP3755_RS12915	COG4251	negative regulation of phosphorylation
LEP3755_RS12925	COG2205	protein histidine kinase activity
LEP3755_RS12945	COG0434	BtpA family
LEP3755_RS12960	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
LEP3755_RS12985	COG5002	protein histidine kinase activity
LEP3755_RS13005	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
LEP3755_RS13010	COG0725	ABC transporter, periplasmic molybdate-binding protein
LEP3755_RS13050	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
LEP3755_RS13055	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
LEP3755_RS13070	COG2186	Transcriptional regulator
LEP3755_RS13080	COG1012	belongs to the aldehyde dehydrogenase family
LEP3755_RS13090	COG1028	Short-chain dehydrogenase reductase Sdr
LEP3755_RS13100	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
LEP3755_RS13115	COG1191	sigma factor activity
LEP3755_RS13150	COG3659	wide pore channel activity
LEP3755_RS13185	COG2261	transglycosylase associated protein
LEP3755_RS13225	COG0484	heat shock protein binding
LEP3755_RS13230	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
LEP3755_RS13260	COG0564	pseudouridine synthase activity
LEP3755_RS13290	COG0515	serine threonine protein kinase
LEP3755_RS13310	COG0438	transferase activity, transferring glycosyl groups
LEP3755_RS13315	COG1619	proteins homologs of microcin C7 resistance protein MccF
LEP3755_RS13330	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LEP3755_RS13345	COG4956	integral membrane protein (PIN domain superfamily)
LEP3755_RS13355	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LEP3755_RS13360	COG0783	Belongs to the Dps family
LEP3755_RS13370	COG0589	response to stress
LEP3755_RS13410	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
LEP3755_RS13415	COG2010	Cytochrome c
LEP3755_RS13420	COG2010	Cytochrome c
LEP3755_RS13430	COG2010	Cytochrome c
LEP3755_RS13435	COG2319	Wd-40 repeat
LEP3755_RS13435	COG4249	Peptidase C14 caspase catalytic subunit p20
LEP3755_RS13440	COG2084	Dehydrogenase
LEP3755_RS13470	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
LEP3755_RS13490	COG0631	protein serine/threonine phosphatase activity
LEP3755_RS13495	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
LEP3755_RS13500	COG3937	granule-associated protein
LEP3755_RS13505	COG0515	serine threonine protein kinase
LEP3755_RS13505	COG1357	PFAM Pentapeptide repeats (8 copies)
LEP3755_RS13510	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
LEP3755_RS13520	COG0724	RNA recognition motif
LEP3755_RS13525	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
LEP3755_RS13530	COG0573	inorganic phosphate transmembrane transporter activity
LEP3755_RS13535	COG0581	inorganic phosphate transmembrane transporter activity
LEP3755_RS13540	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
LEP3755_RS13550	COG0009	L-threonylcarbamoyladenylate synthase
LEP3755_RS13555	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
LEP3755_RS13590	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
LEP3755_RS13605	COG1181	Belongs to the D-alanine--D-alanine ligase family
LEP3755_RS13610	COG0784	Response regulator, receiver
LEP3755_RS13610	COG2205	protein histidine kinase activity
LEP3755_RS13625	COG3842	ATPase activity
LEP3755_RS13630	COG0318	PFAM AMP-dependent synthetase and ligase
LEP3755_RS13635	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
LEP3755_RS13640	COG0784	Response regulator, receiver
LEP3755_RS13640	COG2205	protein histidine kinase activity
LEP3755_RS13645	COG2091	lysine biosynthetic process via aminoadipic acid
LEP3755_RS13655	COG1324	tolerance protein
LEP3755_RS13660	COG1247	-acetyltransferase
LEP3755_RS13675	COG1028	Short-chain dehydrogenase reductase Sdr
LEP3755_RS13695	COG2205	protein histidine kinase activity
LEP3755_RS13725	COG0330	HflC and HflK could
LEP3755_RS13770	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
LEP3755_RS13785	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
LEP3755_RS13835	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
LEP3755_RS13850	COG3961	Belongs to the TPP enzyme family
LEP3755_RS13880	COG0740	serine-type endopeptidase activity
LEP3755_RS13890	COG0640	Transcriptional regulator
LEP3755_RS13900	COG3845	ABC transporter
LEP3755_RS13910	COG1079	Belongs to the binding-protein-dependent transport system permease family
LEP3755_RS13920	COG0515	serine threonine protein kinase
LEP3755_RS13935	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LEP3755_RS13940	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LEP3755_RS13945	COG1120	ATPase activity
LEP3755_RS13955	COG0811	peptide transport
LEP3755_RS13960	COG0848	biopolymer transport protein
LEP3755_RS13970	COG4771	TonB-dependent receptor
LEP3755_RS13980	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
LEP3755_RS13985	COG3845	ABC transporter
LEP3755_RS13995	COG1429	ligase activity, forming nitrogen-metal bonds
LEP3755_RS14025	COG0390	transport system, permease component
LEP3755_RS14030	COG3842	ATPase activity
LEP3755_RS14035	COG2207	Transcriptional regulator
LEP3755_RS14055	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LEP3755_RS14065	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LEP3755_RS14080	COG0848	biopolymer transport protein
LEP3755_RS14085	COG0811	peptide transport
LEP3755_RS14090	COG1840	ABC-type Fe3 transport system, periplasmic component
LEP3755_RS14100	COG0583	DNA-binding transcription factor activity
LEP3755_RS14105	COG0625	glutathione transferase activity
LEP3755_RS14120	COG1301	dicarboxylic acid transport
LEP3755_RS14125	COG1942	4-Oxalocrotonate Tautomerase
LEP3755_RS14130	COG5001	Diguanylate cyclase
LEP3755_RS14130	COG4251	negative regulation of phosphorylation
LEP3755_RS14130	COG3706	GGDEF domain
LEP3755_RS14130	COG2203	Gaf domain
LEP3755_RS14145	COG0859	PFAM glycosyl transferase family 9
LEP3755_RS14155	COG3835	regulator
LEP3755_RS14165	COG0438	transferase activity, transferring glycosyl groups
LEP3755_RS14190	COG5002	protein histidine kinase activity
LEP3755_RS14190	COG0784	Response regulator, receiver
LEP3755_RS14190	COG2205	protein histidine kinase activity
LEP3755_RS14200	COG2197	response regulator
LEP3755_RS14205	COG2197	response regulator
LEP3755_RS14310	COG0435	Glutathione S-transferase
LEP3755_RS14315	COG0625	glutathione transferase activity
LEP3755_RS14330	COG1942	4-Oxalocrotonate Tautomerase
LEP3755_RS14340	COG1960	acyl-CoA dehydrogenase activity
LEP3755_RS14345	COG0183	Belongs to the thiolase family
LEP3755_RS14350	COG1250	3-hydroxyacyl-CoA dehydrogenase
LEP3755_RS14350	COG1024	Enoyl-CoA hydratase
LEP3755_RS14355	COG0318	PFAM AMP-dependent synthetase and ligase
LEP3755_RS14360	COG2267	carboxylic ester hydrolase activity
LEP3755_RS14445	COG3903	Transcriptional regulator
LEP3755_RS14445	COG3903	Transcriptional regulator
LEP3755_RS14445	COG2319	Wd-40 repeat
LEP3755_RS14445	COG2319	Wd-40 repeat
LEP3755_RS14460	COG5002	protein histidine kinase activity
LEP3755_RS14475	COG5001	Diguanylate cyclase
LEP3755_RS14475	COG3706	GGDEF domain
LEP3755_RS14475	COG4251	negative regulation of phosphorylation
LEP3755_RS14475	COG2203	Gaf domain
LEP3755_RS14500	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
LEP3755_RS14505	COG0254	rRNA binding
LEP3755_RS14510	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
LEP3755_RS14515	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
LEP3755_RS14520	COG0101	tRNA pseudouridine synthase activity
LEP3755_RS14525	COG0203	ribosomal protein L17
LEP3755_RS14530	COG0202	RNA polymerase activity
LEP3755_RS14535	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
LEP3755_RS14540	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
LEP3755_RS14545	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
LEP3755_RS14580	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
LEP3755_RS14585	COG3977	Valine--pyruvate aminotransferase
LEP3755_RS14590	COG2337	Toxic component of a toxin-antitoxin (TA) module
LEP3755_RS14595	COG2336	PFAM SpoVT AbrB
LEP3755_RS14610	COG1446	asparaginase
LEP3755_RS14645	COG0628	permease
LEP3755_RS14655	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
LEP3755_RS14665	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LEP3755_RS14670	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LEP3755_RS14675	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LEP3755_RS14680	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
LEP3755_RS14690	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
LEP3755_RS14705	COG3842	ATPase activity
LEP3755_RS14715	COG0601	transmembrane transport
LEP3755_RS14720	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LEP3755_RS14730	COG5002	protein histidine kinase activity
LEP3755_RS14730	COG0784	Response regulator, receiver
LEP3755_RS14730	COG2198	Histidine kinase
LEP3755_RS14745	COG2205	protein histidine kinase activity
LEP3755_RS14745	COG2198	Histidine kinase
LEP3755_RS14745	COG0784	Response regulator, receiver
LEP3755_RS14755	COG3659	wide pore channel activity
LEP3755_RS14760	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
LEP3755_RS14765	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
LEP3755_RS14775	COG1357	PFAM Pentapeptide repeats (8 copies)
LEP3755_RS14775	COG0515	serine threonine protein kinase
LEP3755_RS14785	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
LEP3755_RS14790	COG1959	2 iron, 2 sulfur cluster binding
LEP3755_RS14795	COG0420	3'-5' exonuclease activity
LEP3755_RS14800	COG1230	cation diffusion facilitator family transporter
LEP3755_RS14830	COG0513	Belongs to the DEAD box helicase family
LEP3755_RS14835	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LEP3755_RS14845	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LEP3755_RS14885	COG5183	chlorophyll binding
LEP3755_RS14885	COG2133	pyrroloquinoline quinone binding
LEP3755_RS14890	COG1193	negative regulation of DNA recombination
LEP3755_RS14900	COG0424	maF-like protein
LEP3755_RS14930	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
LEP3755_RS14945	COG3654	unkown
LEP3755_RS15165	COG2801	Transposase and inactivated derivatives
LEP3755_RS15190	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
LEP3755_RS15195	COG1215	transferase activity, transferring glycosyl groups
LEP3755_RS15205	COG1404	Belongs to the peptidase S8 family
LEP3755_RS15240	COG0442	prolyl-tRNA aminoacylation
LEP3755_RS15245	COG2814	Major facilitator Superfamily
LEP3755_RS15265	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
LEP3755_RS15290	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
LEP3755_RS15295	COG0629	single-stranded DNA binding
LEP3755_RS15310	COG1357	PFAM Pentapeptide repeats (8 copies)
LEP3755_RS15310	COG0515	serine threonine protein kinase
LEP3755_RS15315	COG1515	deoxyribonuclease V activity
LEP3755_RS15355	COG2010	Cytochrome c
LEP3755_RS15370	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LEP3755_RS15385	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
LEP3755_RS15390	COG1372	Participates in initiation and elongation during chromosome replication
LEP3755_RS15390	COG0187	DNA topoisomerase II activity
LEP3755_RS15395	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LEP3755_RS15400	COG4533	DNA binding
LEP3755_RS15430	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LEP3755_RS15450	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
LEP3755_RS15460	COG2239	Acts as a magnesium transporter
LEP3755_RS15470	COG3064	Membrane
LEP3755_RS15470	COG0515	serine threonine protein kinase
LEP3755_RS15470	COG4991	sh3 domain protein
LEP3755_RS15480	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
LEP3755_RS15555	COG2890	protein-(glutamine-N5) methyltransferase activity
LEP3755_RS15565	COG1175	transmembrane transport
LEP3755_RS15575	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
LEP3755_RS15580	COG1262	PFAM Formylglycine-generating sulfatase enzyme
LEP3755_RS15585	COG0121	glutamine amidotransferase
LEP3755_RS15590	COG2363	Small membrane protein
LEP3755_RS15595	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LEP3755_RS15630	COG0516	GMP reductase activity
LEP3755_RS15630	COG0517	IMP dehydrogenase activity
LEP3755_RS15640	COG1215	transferase activity, transferring glycosyl groups
LEP3755_RS15650	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
LEP3755_RS15665	COG0667	Aldo Keto reductase
LEP3755_RS15675	COG3659	wide pore channel activity
LEP3755_RS15685	COG0776	regulation of translation
LEP3755_RS15690	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LEP3755_RS15695	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LEP3755_RS15735	COG1309	transcriptional regulator
LEP3755_RS15745	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LEP3755_RS15755	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
LEP3755_RS15785	COG1215	transferase activity, transferring glycosyl groups
LEP3755_RS15900	COG0745	RESPONSE REGULATOR receiver
LEP3755_RS15910	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
LEP3755_RS15915	COG0271	Belongs to the BolA IbaG family
LEP3755_RS15940	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LEP3755_RS15955	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
LEP3755_RS15960	COG1529	Aldehyde oxidase and xanthine dehydrogenase
LEP3755_RS16040	COG1222	aaa ATPase
LEP3755_RS16070	COG0025	NhaP-type Na H and K H
LEP3755_RS16075	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LEP3755_RS16080	COG0227	Belongs to the bacterial ribosomal protein bL28 family
LEP3755_RS16110	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
LEP3755_RS16135	COG2255	four-way junction helicase activity
LEP3755_RS16195	COG0438	transferase activity, transferring glycosyl groups
LEP3755_RS16200	COG0438	transferase activity, transferring glycosyl groups
LEP3755_RS16215	COG1063	alcohol dehydrogenase
LEP3755_RS16295	COG2204	response regulator
LEP3755_RS16300	COG2226	methyltransferase
LEP3755_RS16305	COG4399	Belongs to the UPF0754 family
LEP3755_RS16315	COG1162	GTPase activity
LEP3755_RS16325	COG0484	heat shock protein binding
LEP3755_RS16330	COG0443	Heat shock 70 kDa protein
LEP3755_RS16335	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
LEP3755_RS16340	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LEP3755_RS16350	COG1459	type II secretion system
LEP3755_RS16375	COG0515	serine threonine protein kinase
LEP3755_RS16390	COG0170	dolichyl monophosphate biosynthetic process
LEP3755_RS16400	COG2197	response regulator
LEP3755_RS16425	COG0628	permease
LEP3755_RS16440	COG4603	Belongs to the binding-protein-dependent transport system permease family
LEP3755_RS16445	COG1079	Belongs to the binding-protein-dependent transport system permease family
LEP3755_RS16450	COG3845	ABC transporter
LEP3755_RS16465	COG0606	chelatase, subunit chli
LEP3755_RS16470	COG0537	adenosine 5'-monophosphoramidase activity
LEP3755_RS16475	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
LEP3755_RS16485	COG1836	PFAM Integral membrane protein DUF92
LEP3755_RS16500	COG0708	Exodeoxyribonuclease III
LEP3755_RS16510	COG0154	amidase activity
LEP3755_RS16520	COG1040	competence protein
LEP3755_RS16525	COG0574	Belongs to the PEP-utilizing enzyme family
LEP3755_RS16525	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LEP3755_RS16535	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LEP3755_RS16540	COG0047	phosphoribosylformylglycinamidine synthase activity
LEP3755_RS16545	COG4221	oxidoreductase activity
LEP3755_RS16550	COG0656	L-ascorbic acid biosynthetic process
LEP3755_RS16565	COG0028	Belongs to the TPP enzyme family
LEP3755_RS16670	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
LEP3755_RS16680	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
LEP3755_RS16685	COG0540	Belongs to the ATCase OTCase family
LEP3755_RS16875	COG3561	AntA/AntB antirepressor
LEP3755_RS16915	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
LEP3755_RS16930	COG3118	belongs to the thioredoxin family
LEP3755_RS16935	COG0516	GMP reductase activity
LEP3755_RS16950	COG0463	Glycosyl transferase, family 2
LEP3755_RS16960	COG0640	Transcriptional regulator
LEP3755_RS16975	COG0371	Dehydrogenase
LEP3755_RS16980	COG2814	Major facilitator Superfamily
LEP3755_RS16985	COG4585	Histidine kinase
LEP3755_RS16990	COG2197	response regulator
LEP3755_RS17005	COG0318	PFAM AMP-dependent synthetase and ligase
LEP3755_RS17015	COG1575	Belongs to the MenA family. Type 1 subfamily
LEP3755_RS17020	COG0149	triose-phosphate isomerase activity
LEP3755_RS17030	COG4279	zinc finger
LEP3755_RS17035	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
LEP3755_RS17040	COG1185	polyribonucleotide nucleotidyltransferase activity
LEP3755_RS17050	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
LEP3755_RS17055	COG2205	protein histidine kinase activity
LEP3755_RS17060	COG0820	rRNA (adenine-C2-)-methyltransferase activity
LEP3755_RS17075	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
LEP3755_RS17090	COG0123	including yeast histone deacetylase and acetoin utilization protein
LEP3755_RS17105	COG0745	RESPONSE REGULATOR receiver
LEP3755_RS17140	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
LEP3755_RS17170	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LEP3755_RS17190	COG0706	membrane insertase activity
LEP3755_RS17200	COG0594	ribonuclease P activity
LEP3755_RS17215	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
LEP3755_RS17220	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
LEP3755_RS17245	COG1335	isochorismatase
LEP3755_RS17280	COG1012	belongs to the aldehyde dehydrogenase family
LEP3755_RS17285	COG2207	Transcriptional regulator
LEP3755_RS17315	COG1028	Short-chain dehydrogenase reductase Sdr
LEP3755_RS17320	COG0667	Aldo Keto reductase
LEP3755_RS17325	COG1695	Transcriptional regulator
LEP3755_RS17335	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
LEP3755_RS17365	COG0025	NhaP-type Na H and K H
LEP3755_RS17370	COG0667	Aldo Keto reductase
LEP3755_RS17375	COG0667	Aldo Keto reductase
LEP3755_RS17380	COG0656	L-ascorbic acid biosynthetic process
LEP3755_RS17385	COG1064	alcohol dehydrogenase
LEP3755_RS17390	COG2207	Transcriptional regulator
LEP3755_RS17490	COG4974	Belongs to the 'phage' integrase family
LEP3755_RS17510	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
LEP3755_RS17520	COG3335	DDE superfamily endonuclease
LEP3755_RS17565	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
LEP3755_RS17615	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
LEP3755_RS17620	COG2340	Cysteine-rich secretory protein family
LEP3755_RS17635	COG2801	Transposase and inactivated derivatives
LEP3755_RS17700	COG1028	Short-chain dehydrogenase reductase Sdr
LEP3755_RS17825	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
LEP3755_RS17830	COG2066	Belongs to the glutaminase family
LEP3755_RS17845	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
LEP3755_RS17850	COG2233	PERMEase
LEP3755_RS17860	COG2233	PERMEase
LEP3755_RS17900	COG1136	(ABC) transporter
LEP3755_RS17900	COG0577	efflux transmembrane transporter activity
LEP3755_RS17910	COG0561	phosphatase activity
LEP3755_RS17915	COG2884	Cell division ATP-binding protein ftsE
LEP3755_RS17930	COG3179	chitinase
LEP3755_RS17945	COG0504	CTP synthase activity
LEP3755_RS17950	COG0860	N-Acetylmuramoyl-L-alanine amidase
LEP3755_RS17960	COG4213	ABC transporter substrate-binding protein
LEP3755_RS17970	COG1845	cytochrome c oxidase, subunit III
LEP3755_RS17980	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
LEP3755_RS17995	COG1361	Conserved repeat domain
LEP3755_RS18015	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
LEP3755_RS18025	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
LEP3755_RS18045	COG0740	serine-type endopeptidase activity
LEP3755_RS18050	COG0740	serine-type endopeptidase activity
LEP3755_RS18055	COG0740	serine-type endopeptidase activity
LEP3755_RS18060	COG0484	heat shock protein binding
LEP3755_RS18100	COG1077	Cell shape determining protein MreB Mrl
LEP3755_RS18105	COG0629	single-stranded DNA binding
LEP3755_RS18120	COG1595	DNA-templated transcription, initiation
LEP3755_RS18125	COG2161	toxin-antitoxin pair type II binding
LEP3755_RS18130	COG4115	mRNA cleavage
LEP3755_RS18135	COG4221	oxidoreductase activity
LEP3755_RS18140	COG0045	succinate-CoA ligase (ADP-forming) activity
LEP3755_RS18155	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
LEP3755_RS18155	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
LEP3755_RS18170	COG2304	oxidoreductase activity
LEP3755_RS18175	COG1690	Belongs to the RtcB family
LEP3755_RS18190	COG0123	including yeast histone deacetylase and acetoin utilization protein
LEP3755_RS18195	COG0501	Belongs to the peptidase M48B family
LEP3755_RS18210	COG1716	ATPase activity
LEP3755_RS18225	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LEP3755_RS18250	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
LEP3755_RS18250	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
LEP3755_RS18255	COG0300	oxidoreductase activity
LEP3755_RS18280	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
LEP3755_RS18285	COG0333	Belongs to the bacterial ribosomal protein bL32 family
LEP3755_RS18290	COG0419	ATPase involved in DNA repair
LEP3755_RS18345	COG2815	serine threonine protein kinase
LEP3755_RS18345	COG0515	serine threonine protein kinase
LEP3755_RS18355	COG2815	serine threonine protein kinase
LEP3755_RS18355	COG0515	serine threonine protein kinase
LEP3755_RS18370	COG2815	serine threonine protein kinase
LEP3755_RS18370	COG0515	serine threonine protein kinase
LEP3755_RS18390	COG4249	Peptidase C14 caspase catalytic subunit p20
LEP3755_RS18390	COG2319	Wd-40 repeat
LEP3755_RS18410	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
LEP3755_RS18445	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LEP3755_RS18445	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
LEP3755_RS18465	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
LEP3755_RS18475	COG0402	S-adenosylhomocysteine deaminase activity
LEP3755_RS18480	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
LEP3755_RS18485	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LEP3755_RS18490	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
LEP3755_RS18505	COG0583	DNA-binding transcription factor activity
LEP3755_RS18545	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
LEP3755_RS18550	COG2046	Belongs to the sulfate adenylyltransferase family
LEP3755_RS18615	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LEP3755_RS18620	COG0670	Belongs to the BI1 family
LEP3755_RS18625	COG0583	DNA-binding transcription factor activity
LEP3755_RS18665	COG2815	serine threonine protein kinase
LEP3755_RS18665	COG0515	serine threonine protein kinase
LEP3755_RS18675	COG3118	belongs to the thioredoxin family
LEP3755_RS18680	COG3210	domain, Protein
LEP3755_RS18705	COG0233	cytoplasmic translational termination
LEP3755_RS18710	COG0528	UMP kinase activity
LEP3755_RS18725	COG0667	Aldo Keto reductase
LEP3755_RS18735	COG3848	Pyruvate phosphate dikinase
LEP3755_RS18735	COG0574	Belongs to the PEP-utilizing enzyme family
LEP3755_RS18755	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
LEP3755_RS18770	COG0463	Glycosyl transferase, family 2
LEP3755_RS18775	COG0745	RESPONSE REGULATOR receiver
LEP3755_RS18795	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LEP3755_RS18800	COG4372	Transposase
LEP3755_RS18820	COG2442	InterPro IPR007367
LEP3755_RS18860	COG0356	it plays a direct role in the translocation of protons across the membrane
LEP3755_RS18865	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LEP3755_RS18870	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
LEP3755_RS18875	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
LEP3755_RS18880	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LEP3755_RS18885	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
LEP3755_RS18890	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
LEP3755_RS18895	COG3596	GTP binding
LEP3755_RS18935	COG5001	Diguanylate cyclase
LEP3755_RS18935	COG1716	ATPase activity
LEP3755_RS18940	COG2217	Heavy metal translocating P-type atpase
LEP3755_RS18990	COG1442	glycosyl transferase family 8
LEP3755_RS18990	COG1216	Glycosyl transferase, family 2
LEP3755_RS18995	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
LEP3755_RS19015	COG2244	polysaccharide biosynthetic process
LEP3755_RS19020	COG1215	transferase activity, transferring glycosyl groups
LEP3755_RS19040	COG0215	cysteine-tRNA ligase activity
LEP3755_RS19045	COG0523	cobalamin synthesis protein
LEP3755_RS19055	COG1490	D-aminoacyl-tRNA deacylase activity
LEP3755_RS19060	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
LEP3755_RS19075	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
LEP3755_RS19085	COG3293	Transposase
LEP3755_RS19095	COG0133	tryptophan synthase activity
LEP3755_RS19115	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LEP3755_RS19120	COG2135	peptidase activity
LEP3755_RS19130	COG1132	(ABC) transporter
LEP3755_RS19135	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
LEP3755_RS19140	COG0745	RESPONSE REGULATOR receiver
LEP3755_RS19160	COG0438	transferase activity, transferring glycosyl groups
LEP3755_RS19230	COG2319	Wd-40 repeat
LEP3755_RS19230	COG3903	Transcriptional regulator
LEP3755_RS19235	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
LEP3755_RS19245	COG0109	protoheme IX farnesyltransferase activity
LEP3755_RS19255	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
LEP3755_RS19265	COG1845	cytochrome c oxidase, subunit III
LEP3755_RS19280	COG1196	nuclear chromosome segregation
LEP3755_RS19310	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
LEP3755_RS19335	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
LEP3755_RS19340	COG1799	cell septum assembly
LEP3755_RS19365	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LEP3755_RS19375	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
LEP3755_RS19385	COG0793	Belongs to the peptidase S41A family
LEP3755_RS19410	COG1361	Conserved repeat domain
LEP3755_RS19415	COG2205	protein histidine kinase activity
LEP3755_RS19435	COG2197	response regulator
LEP3755_RS19445	COG0454	-acetyltransferase
LEP3755_RS19465	COG2197	response regulator
LEP3755_RS19475	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
LEP3755_RS19490	COG1054	Belongs to the UPF0176 family
LEP3755_RS19500	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
LEP3755_RS19510	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LEP3755_RS19515	COG2385	sporulation resulting in formation of a cellular spore
LEP3755_RS19525	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LEP3755_RS19530	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LEP3755_RS19535	COG1116	anion transmembrane transporter activity
LEP3755_RS19535	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LEP3755_RS19540	COG1116	anion transmembrane transporter activity
LEP3755_RS19560	COG1132	(ABC) transporter
LEP3755_RS19595	COG1385	rRNA (uridine-N3-)-methyltransferase activity
LEP3755_RS19605	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LEP3755_RS19610	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LEP3755_RS19615	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
LEP3755_RS19630	COG0745	RESPONSE REGULATOR receiver
LEP3755_RS19645	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LEP3755_RS19650	COG0457	Tetratricopeptide repeat
LEP3755_RS19680	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
LEP3755_RS19685	COG0581	inorganic phosphate transmembrane transporter activity
LEP3755_RS19690	COG0573	inorganic phosphate transmembrane transporter activity
LEP3755_RS19695	COG3659	wide pore channel activity
LEP3755_RS19700	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
LEP3755_RS19715	COG0848	biopolymer transport protein
LEP3755_RS19720	COG0811	peptide transport
LEP3755_RS19755	COG0300	oxidoreductase activity
LEP3755_RS19765	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
LEP3755_RS19770	COG0601	transmembrane transport
LEP3755_RS19790	COG0247	lactate metabolic process
LEP3755_RS19795	COG0277	FAD linked oxidase domain protein
LEP3755_RS19805	COG2205	protein histidine kinase activity
LEP3755_RS19805	COG0784	Response regulator, receiver
LEP3755_RS19815	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
LEP3755_RS19840	COG0159	tryptophan synthase activity
LEP3755_RS19875	COG0668	transmembrane transport
LEP3755_RS19890	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
LEP3755_RS19910	COG0745	RESPONSE REGULATOR receiver
LEP3755_RS19925	COG1125	glycine betaine transport
LEP3755_RS19925	COG0517	IMP dehydrogenase activity
LEP3755_RS19935	COG3852	Histidine kinase
LEP3755_RS19940	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
LEP3755_RS19945	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
LEP3755_RS19950	COG1660	Displays ATPase and GTPase activities
LEP3755_RS19980	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
LEP3755_RS19985	COG0745	RESPONSE REGULATOR receiver
LEP3755_RS19990	COG5002	protein histidine kinase activity
LEP3755_RS20000	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LEP3755_RS20015	COG4294	response to UV
LEP3755_RS20045	COG1172	Belongs to the binding-protein-dependent transport system permease family
LEP3755_RS20050	COG1129	ABC transporter
LEP3755_RS20055	COG1879	ABC-type sugar transport system periplasmic component
LEP3755_RS20065	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LEP3755_RS20075	COG2197	response regulator
LEP3755_RS20085	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
LEP3755_RS20115	COG0701	Predicted permease
LEP3755_RS20125	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
LEP3755_RS20130	COG0745	RESPONSE REGULATOR receiver
LEP3755_RS20135	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
LEP3755_RS20140	COG0728	peptidoglycan biosynthetic process
LEP3755_RS20160	COG1002	Type II restriction enzyme, methylase subunits
LEP3755_RS20165	COG0366	Alpha amylase catalytic
LEP3755_RS20180	COG1842	Phage shock protein A
LEP3755_RS20190	COG0346	lactoylglutathione lyase activity
LEP3755_RS20210	COG1252	NADH dehydrogenase
LEP3755_RS20245	COG1214	PFAM Peptidase M22, glycoprotease
LEP3755_RS20250	COG2188	Transcriptional regulator
LEP3755_RS20260	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LEP3755_RS20265	COG0174	glutamine synthetase
LEP3755_RS20310	COG4447	cellulose binding
LEP3755_RS20315	COG1773	rubredoxin
LEP3755_RS20320	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LEP3755_RS20325	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LEP3755_RS20330	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LEP3755_RS20350	COG2319	Wd-40 repeat
LEP3755_RS20360	COG2010	Cytochrome c
LEP3755_RS20370	COG2003	Belongs to the UPF0758 family
LEP3755_RS20395	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
LEP3755_RS20400	COG1058	Belongs to the CinA family
LEP3755_RS20400	COG1546	Belongs to the CinA family
LEP3755_RS20405	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LEP3755_RS20410	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LEP3755_RS20420	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
LEP3755_RS20430	COG0784	Response regulator, receiver
LEP3755_RS20435	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
LEP3755_RS20470	COG1376	ErfK ybiS ycfS ynhG family protein
LEP3755_RS20490	COG0438	transferase activity, transferring glycosyl groups
LEP3755_RS20495	COG0515	serine threonine protein kinase
LEP3755_RS20505	COG1830	Aldolase
LEP3755_RS20510	COG0436	Aminotransferase
LEP3755_RS20530	COG1950	PFAM Membrane protein of
LEP3755_RS20540	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LEP3755_RS20545	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LEP3755_RS20555	COG0632	four-way junction helicase activity
LEP3755_RS20560	COG0561	phosphatase activity
LEP3755_RS20575	COG0210	DNA helicase
LEP3755_RS20585	COG2755	lipolytic protein G-D-S-L family
LEP3755_RS20615	COG0651	ATP synthesis coupled electron transport
LEP3755_RS20630	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
LEP3755_RS20630	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
LEP3755_RS20635	COG0859	PFAM glycosyl transferase family 9
LEP3755_RS20640	COG2261	transglycosylase associated protein
LEP3755_RS20645	COG0724	RNA recognition motif
LEP3755_RS20650	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
LEP3755_RS20670	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
LEP3755_RS20690	COG1253	flavin adenine dinucleotide binding
LEP3755_RS20695	COG0511	ligase activity, forming carbon-carbon bonds
LEP3755_RS20700	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
LEP3755_RS20705	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LEP3755_RS20745	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
LEP3755_RS20770	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
LEP3755_RS20780	COG0154	amidase activity
LEP3755_RS20790	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LEP3755_RS20800	COG0534	Mate efflux family protein
LEP3755_RS20805	COG0842	Transport permease protein
LEP3755_RS20825	COG3046	protein related to deoxyribodipyrimidine photolyase
LEP3755_RS20845	COG1012	belongs to the aldehyde dehydrogenase family
LEP3755_RS20905	COG0515	serine threonine protein kinase
LEP3755_RS20910	COG0515	serine threonine protein kinase
LEP3755_RS20910	COG3064	Membrane
LEP3755_RS20910	COG4991	sh3 domain protein
LEP3755_RS20915	COG0758	DNA mediated transformation
LEP3755_RS20915	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
LEP3755_RS20920	COG3437	response regulator, receiver
LEP3755_RS20925	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
LEP3755_RS20930	COG0582	viral genome integration into host DNA
LEP3755_RS20935	COG2226	methyltransferase
LEP3755_RS20940	COG1136	(ABC) transporter
LEP3755_RS20950	COG2217	Heavy metal translocating P-type atpase
LEP3755_RS21020	COG2217	Heavy metal translocating P-type atpase
LEP3755_RS21025	COG1262	PFAM Formylglycine-generating sulfatase enzyme
LEP3755_RS21035	COG2217	Heavy metal translocating P-type atpase
LEP3755_RS21045	COG0592	DNA-directed DNA polymerase activity
LEP3755_RS21055	COG0582	viral genome integration into host DNA
LEP3755_RS21235	COG2203	Gaf domain
LEP3755_RS21235	COG5001	Diguanylate cyclase
LEP3755_RS21235	COG4251	negative regulation of phosphorylation
LEP3755_RS21235	COG3706	GGDEF domain
LEP3755_RS21240	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
LEP3755_RS21245	COG1595	DNA-templated transcription, initiation
LEP3755_RS21265	COG2203	Gaf domain
LEP3755_RS21265	COG5001	Diguanylate cyclase
LEP3755_RS21265	COG3706	GGDEF domain
LEP3755_RS21265	COG4251	negative regulation of phosphorylation
LEP3755_RS21270	COG0457	Tetratricopeptide repeat
LEP3755_RS21285	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
LEP3755_RS21290	COG1028	Short-chain dehydrogenase reductase Sdr
LEP3755_RS21330	COG1132	(ABC) transporter
LEP3755_RS21360	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LEP3755_RS21365	COG0438	transferase activity, transferring glycosyl groups
LEP3755_RS21370	COG1216	Glycosyl transferase, family 2
LEP3755_RS21375	COG4172	Belongs to the ABC transporter superfamily
LEP3755_RS21415	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
LEP3755_RS21425	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
LEP3755_RS21430	COG1610	YqeY-like protein
LEP3755_RS21435	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
LEP3755_RS21465	COG0586	Pfam SNARE associated Golgi protein
LEP3755_RS21470	COG0586	Pfam SNARE associated Golgi protein
LEP3755_RS21475	COG1132	(ABC) transporter
LEP3755_RS21485	COG1662	PFAM IS1 transposase
LEP3755_RS21490	COG0501	Belongs to the peptidase M48B family
LEP3755_RS21520	COG0024	Methionine aminopeptidase
LEP3755_RS21560	COG4555	ABC transporter
LEP3755_RS21575	COG0038	chloride channel
LEP3755_RS21605	COG0493	'glutamate synthase
LEP3755_RS21615	COG0489	protein tyrosine kinase activity
LEP3755_RS21635	COG0297	glycogen (starch) synthase activity
LEP3755_RS21675	COG1088	dTDP-glucose 4,6-dehydratase activity
LEP3755_RS21685	COG1091	dTDP-4-dehydrorhamnose reductase activity
LEP3755_RS21700	COG1216	Glycosyl transferase, family 2
LEP3755_RS21705	COG1215	transferase activity, transferring glycosyl groups
LEP3755_RS21710	COG1442	glycosyl transferase family 8
LEP3755_RS21715	COG1216	Glycosyl transferase, family 2
LEP3755_RS21730	COG1216	Glycosyl transferase, family 2
LEP3755_RS21735	COG1216	Glycosyl transferase, family 2
LEP3755_RS21750	COG1216	Glycosyl transferase, family 2
LEP3755_RS21770	COG0438	transferase activity, transferring glycosyl groups
LEP3755_RS21770	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
LEP3755_RS21790	COG0297	glycogen (starch) synthase activity
LEP3755_RS21810	COG0438	transferase activity, transferring glycosyl groups
LEP3755_RS21815	COG0367	asparagine synthase
LEP3755_RS21900	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
LEP3755_RS21985	COG5635	Nacht domain
LEP3755_RS21985	COG2319	Wd-40 repeat
LEP3755_RS21995	COG2319	Wd-40 repeat
LEP3755_RS21995	COG5635	Nacht domain
LEP3755_RS22010	COG3903	Transcriptional regulator
LEP3755_RS22010	COG2319	Wd-40 repeat
LEP3755_RS22130	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LEP3755_RS22130	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
LEP3755_RS22160	COG0745	RESPONSE REGULATOR receiver
LEP3755_RS22185	COG0297	glycogen (starch) synthase activity
LEP3755_RS22205	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
LEP3755_RS22215	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
LEP3755_RS22220	COG2172	sigma factor antagonist activity
LEP3755_RS22230	COG0066	3-isopropylmalate dehydratase activity
LEP3755_RS22235	COG2954	triphosphatase activity
LEP3755_RS22245	COG2124	cytochrome p450
LEP3755_RS22250	COG0431	NADPH-dependent FMN reductase
LEP3755_RS22255	COG4251	negative regulation of phosphorylation
LEP3755_RS22270	COG5002	protein histidine kinase activity
LEP3755_RS22285	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
LEP3755_RS22290	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LEP3755_RS22320	COG1404	Belongs to the peptidase S8 family
LEP3755_RS22335	COG4636	protein conserved in cyanobacteria
LEP3755_RS22340	COG0148	phosphopyruvate hydratase activity
LEP3755_RS22345	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
LEP3755_RS22360	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
LEP3755_RS22365	COG0494	nUDIX hydrolase
LEP3755_RS22370	COG0415	Belongs to the DNA photolyase family
LEP3755_RS22375	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LEP3755_RS22380	COG1940	carbohydrate kinase activity
LEP3755_RS22415	COG0704	Plays a role in the regulation of phosphate uptake
LEP3755_RS22425	COG1335	isochorismatase
LEP3755_RS22445	COG0826	peptidase U32
LEP3755_RS22450	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LEP3755_RS22480	COG2081	HI0933 family
LEP3755_RS22505	COG0297	glycogen (starch) synthase activity
LEP3755_RS22520	COG0181	hydroxymethylbilane synthase activity
LEP3755_RS22525	COG1598	PFAM Uncharacterised protein family UPF0150
LEP3755_RS22535	COG2022	thiamine diphosphate biosynthetic process
LEP3755_RS22535	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LEP3755_RS22545	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LEP3755_RS22585	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
LEP3755_RS22630	COG0746	molybdenum cofactor guanylyltransferase activity
LEP3755_RS22635	COG0095	Lipoate-protein ligase
LEP3755_RS22670	COG1132	(ABC) transporter
LEP3755_RS22725	COG2226	methyltransferase
LEP3755_RS22740	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
LEP3755_RS22745	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LEP3755_RS22760	COG1713	HD superfamily hydrolase involved in NAD metabolism
LEP3755_RS22765	COG0799	negative regulation of ribosome biogenesis
LEP3755_RS22780	COG4191	Histidine kinase
LEP3755_RS22800	COG1073	alpha beta
LEP3755_RS22815	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
LEP3755_RS22820	COG1570	exodeoxyribonuclease VII activity
LEP3755_RS22825	COG1722	exodeoxyribonuclease VII activity
LEP3755_RS22835	COG1131	(ABC) transporter
LEP3755_RS22845	COG2264	protein methyltransferase activity
LEP3755_RS22860	COG0776	regulation of translation
LEP3755_RS22870	COG0488	(ABC) transporter
LEP3755_RS22885	COG1672	PFAM Archaeal ATPase
LEP3755_RS22885	COG2319	Wd-40 repeat
LEP3755_RS22895	COG0450	alkyl hydroperoxide reductase
LEP3755_RS22930	COG0863	Belongs to the N(4) N(6)-methyltransferase family
LEP3755_RS22940	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
LEP3755_RS22945	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
LEP3755_RS22950	COG0512	Glutamine amidotransferase of anthranilate synthase
LEP3755_RS22970	COG1316	TRANSCRIPTIONal
LEP3755_RS22995	COG3394	polysaccharide catabolic process
LEP3755_RS23010	COG0475	glutathione-regulated potassium exporter activity
LEP3755_RS23015	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
LEP3755_RS23020	COG0583	DNA-binding transcription factor activity
LEP3755_RS23030	COG1090	epimerase
LEP3755_RS23035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
LEP3755_RS23065	COG0515	serine threonine protein kinase
LEP3755_RS23065	COG1357	PFAM Pentapeptide repeats (8 copies)
LEP3755_RS23090	COG2358	TRAP transporter, solute receptor (TAXI family
LEP3755_RS23100	COG0438	transferase activity, transferring glycosyl groups
LEP3755_RS23110	COG1215	transferase activity, transferring glycosyl groups
LEP3755_RS23115	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
LEP3755_RS23120	COG0673	inositol 2-dehydrogenase activity
LEP3755_RS23145	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LEP3755_RS23150	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
LEP3755_RS23160	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
LEP3755_RS23175	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
LEP3755_RS23185	COG0489	protein tyrosine kinase activity
LEP3755_RS23195	COG1215	transferase activity, transferring glycosyl groups
LEP3755_RS23205	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
LEP3755_RS23225	COG1215	transferase activity, transferring glycosyl groups
LEP3755_RS23230	COG5002	protein histidine kinase activity
LEP3755_RS23230	COG2205	protein histidine kinase activity
LEP3755_RS23230	COG0784	Response regulator, receiver
LEP3755_RS23245	COG0402	S-adenosylhomocysteine deaminase activity
LEP3755_RS23255	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
LEP3755_RS23275	COG0210	DNA helicase
LEP3755_RS23305	COG0395	ABC-type sugar transport system, permease component
LEP3755_RS23310	COG0217	transcriptional regulatory protein
LEP3755_RS23315	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LEP3755_RS23330	COG3266	domain, Protein
LEP3755_RS23330	COG0515	serine threonine protein kinase
LEP3755_RS23335	COG1876	peptidase activity
LEP3755_RS23350	COG0739	heme binding
LEP3755_RS23350	COG0741	lytic transglycosylase activity
LEP3755_RS23350	COG1196	nuclear chromosome segregation
LEP3755_RS23355	COG1496	oxidoreductase activity
LEP3755_RS23390	COG1215	transferase activity, transferring glycosyl groups
LEP3755_RS23395	COG4214	carbohydrate transport
LEP3755_RS23405	COG4213	ABC transporter substrate-binding protein
LEP3755_RS23420	COG0519	Catalyzes the synthesis of GMP from XMP
LEP3755_RS23425	COG0726	polysaccharide deacetylase
LEP3755_RS23440	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
LEP3755_RS23465	COG4636	protein conserved in cyanobacteria
LEP3755_RS23470	COG2223	nitrite transmembrane transporter activity
LEP3755_RS23475	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LEP3755_RS23505	COG0617	tRNA 3'-terminal CCA addition
LEP3755_RS23520	COG0508	dehydrogenase complex catalyzes the overall conversion of
LEP3755_RS23535	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LEP3755_RS23535	COG0784	Response regulator, receiver
LEP3755_RS23535	COG2205	protein histidine kinase activity
LEP3755_RS23535	COG2198	Histidine kinase
LEP3755_RS23540	COG0285	dihydrofolate synthase activity
LEP3755_RS23545	COG0083	homoserine kinase activity
LEP3755_RS23565	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
LEP3755_RS23570	COG0438	transferase activity, transferring glycosyl groups
LEP3755_RS23575	COG1215	transferase activity, transferring glycosyl groups
LEP3755_RS23595	COG0531	amino acid
LEP3755_RS23605	COG0602	queuosine metabolic process
LEP3755_RS23730	COG4243	Vitamin k epoxide reductase
LEP3755_RS23750	COG4783	chaperone-mediated protein folding
LEP3755_RS23790	COG3852	Histidine kinase
LEP3755_RS23795	COG3842	ATPase activity
LEP3755_RS23810	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LEP3755_RS23835	COG0406	alpha-ribazole phosphatase activity
LEP3755_RS23865	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LEP3755_RS23875	COG1007	ATP synthesis coupled electron transport
LEP3755_RS23890	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
LEP3755_RS23895	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
LEP3755_RS23925	COG0416	fatty acid biosynthetic process
LEP3755_RS23930	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LEP3755_RS23935	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
LEP3755_RS23945	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
LEP3755_RS23955	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LEP3755_RS23965	COG1672	PFAM Archaeal ATPase
LEP3755_RS23965	COG2319	Wd-40 repeat
LEP3755_RS23980	COG0515	serine threonine protein kinase
LEP3755_RS23980	COG1357	PFAM Pentapeptide repeats (8 copies)
LEP3755_RS23995	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
LEP3755_RS24010	COG0415	Belongs to the DNA photolyase family
LEP3755_RS24050	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
LEP3755_RS24055	COG0653	protein targeting
LEP3755_RS24100	COG0454	-acetyltransferase
LEP3755_RS24105	COG0783	Belongs to the Dps family
LEP3755_RS24140	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LEP3755_RS24145	COG0464	growth
LEP3755_RS24150	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
LEP3755_RS24180	COG1074	ATP-dependent DNA helicase activity
LEP3755_RS24215	COG1191	sigma factor activity
LEP3755_RS24225	COG2326	polyphosphate kinase activity
LEP3755_RS24275	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
LEP3755_RS24300	COG0432	Pfam Uncharacterised protein family UPF0047
LEP3755_RS24310	COG0640	Transcriptional regulator
LEP3755_RS24315	COG0673	inositol 2-dehydrogenase activity
LEP3755_RS24325	COG2340	Cysteine-rich secretory protein family
LEP3755_RS24330	COG2166	iron-sulfur cluster assembly
LEP3755_RS24350	COG0724	RNA recognition motif
LEP3755_RS24355	COG0828	Belongs to the bacterial ribosomal protein bS21 family
LEP3755_RS24370	COG0460	homoserine dehydrogenase
LEP3755_RS24375	COG0022	dehydrogenase e1 component
LEP3755_RS24375	COG0508	dehydrogenase complex catalyzes the overall conversion of
LEP3755_RS24385	COG2202	Pas domain
LEP3755_RS24385	COG2205	protein histidine kinase activity
LEP3755_RS24400	COG0352	thiamine-phosphate diphosphorylase activity
LEP3755_RS24410	COG0644	oxidoreductase
LEP3755_RS24425	COG5002	protein histidine kinase activity
LEP3755_RS24425	COG2198	Histidine kinase
LEP3755_RS24425	COG0784	Response regulator, receiver
LEP3755_RS24440	COG1316	TRANSCRIPTIONal
LEP3755_RS24445	COG0662	Cupin 2, conserved barrel domain protein
LEP3755_RS24445	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
LEP3755_RS24460	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
LEP3755_RS24465	COG0303	'Molybdopterin
LEP3755_RS24470	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
LEP3755_RS24500	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
LEP3755_RS24505	COG0811	peptide transport
LEP3755_RS24510	COG0848	biopolymer transport protein
LEP3755_RS24520	COG4106	trans-aconitate 2-methyltransferase activity
LEP3755_RS24555	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LEP3755_RS24560	COG4680	protein conserved in bacteria
LEP3755_RS24570	COG0811	peptide transport
LEP3755_RS24575	COG0848	biopolymer transport protein
LEP3755_RS24580	COG1850	ribulose-bisphosphate carboxylase activity
LEP3755_RS24590	COG4451	ribulose bisphosphate carboxylase, small
LEP3755_RS24645	COG0438	transferase activity, transferring glycosyl groups
LEP3755_RS24645	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
LEP3755_RS24650	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LEP3755_RS24655	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LEP3755_RS24670	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
LEP3755_RS24685	COG5002	protein histidine kinase activity
LEP3755_RS24720	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
LEP3755_RS24740	COG3842	ATPase activity
LEP3755_RS24745	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
LEP3755_RS24750	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
LEP3755_RS24755	COG1234	tRNA 3'-trailer cleavage
LEP3755_RS24760	COG2385	sporulation resulting in formation of a cellular spore
LEP3755_RS24770	COG0616	signal peptide processing
LEP3755_RS24775	COG0697	spore germination
LEP3755_RS24785	COG4249	Peptidase C14 caspase catalytic subunit p20
LEP3755_RS24785	COG2319	Wd-40 repeat
LEP3755_RS24825	COG1742	UPF0060 membrane protein
LEP3755_RS24830	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LEP3755_RS24835	COG0628	permease
LEP3755_RS24855	COG0514	ATP-dependent DNA helicase (RecQ)
LEP3755_RS24860	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
LEP3755_RS24870	COG0463	Glycosyl transferase, family 2
LEP3755_RS24870	COG0457	Tetratricopeptide repeat
LEP3755_RS24875	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LEP3755_RS24880	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
LEP3755_RS24910	COG0675	Transposase, IS605 OrfB family
LEP3755_RS24920	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
LEP3755_RS24980	COG0402	S-adenosylhomocysteine deaminase activity
LEP3755_RS24995	COG0124	histidyl-tRNA synthetase
LEP3755_RS25000	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
LEP3755_RS25010	COG0438	transferase activity, transferring glycosyl groups
LEP3755_RS25015	COG1554	hydrolase, family 65, central catalytic
LEP3755_RS25030	COG0655	NAD(P)H dehydrogenase (quinone) activity
LEP3755_RS25060	COG0191	fructose-bisphosphate aldolase activity
LEP3755_RS25075	COG0189	ligase activity
LEP3755_RS25080	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
LEP3755_RS25085	COG3751	2OG-Fe(II) oxygenase superfamily
LEP3755_RS25110	COG1132	(ABC) transporter
LEP3755_RS25115	COG1160	GTP binding
LEP3755_RS25130	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LEP3755_RS25135	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
LEP3755_RS25140	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
LEP3755_RS25150	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
LEP3755_RS25190	COG0596	Alpha beta hydrolase
LEP3755_RS25205	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
LEP3755_RS25220	COG2304	oxidoreductase activity
LEP3755_RS25250	COG5002	protein histidine kinase activity
LEP3755_RS25270	COG0672	)-iron permease
LEP3755_RS25310	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
LEP3755_RS25320	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
LEP3755_RS25345	COG0612	Peptidase, M16
LEP3755_RS25350	COG0612	Peptidase, M16
LEP3755_RS25375	COG4191	Histidine kinase
LEP3755_RS25380	COG0288	reversible hydration of carbon dioxide
LEP3755_RS25385	COG0751	glycine-tRNA ligase activity
LEP3755_RS25415	COG0829	nickel cation binding
LEP3755_RS25420	COG0831	urea catabolic process
LEP3755_RS25425	COG0832	Belongs to the urease beta subunit family
LEP3755_RS25435	COG1361	Conserved repeat domain
LEP3755_RS25435	COG3266	domain, Protein
LEP3755_RS25435	COG2911	Protein conserved in bacteria
LEP3755_RS25480	COG1640	4-alpha-glucanotransferase
LEP3755_RS25490	COG0251	oxidation-reduction process
LEP3755_RS25495	COG2197	response regulator
LEP3755_RS25505	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
LEP3755_RS25510	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
LEP3755_RS25520	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
LEP3755_RS25525	COG2205	protein histidine kinase activity
LEP3755_RS25560	COG1597	lipid kinase activity
LEP3755_RS25560	COG1803	Methylglyoxal synthase
LEP3755_RS25595	COG0156	8-amino-7-oxononanoate synthase activity
LEP3755_RS25615	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LEP3755_RS25650	COG5002	protein histidine kinase activity
LEP3755_RS25650	COG3447	MASE1 domain protein
LEP3755_RS25650	COG5001	Diguanylate cyclase
LEP3755_RS25655	COG2204	response regulator
LEP3755_RS25660	COG0784	Response regulator, receiver
LEP3755_RS25675	COG3266	domain, Protein
LEP3755_RS25675	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
LEP3755_RS25685	COG0195	Participates in both transcription termination and antitermination
LEP3755_RS25690	COG0779	Required for maturation of 30S ribosomal subunits
LEP3755_RS25695	COG3659	wide pore channel activity
LEP3755_RS25700	COG0291	Belongs to the bacterial ribosomal protein bL35 family
LEP3755_RS25705	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
LEP3755_RS25755	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
LEP3755_RS25795	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
LEP3755_RS25805	COG1598	PFAM Uncharacterised protein family UPF0150
LEP3755_RS25815	COG3688	RNA-binding protein containing a PIN domain
LEP3755_RS25865	COG1122	ATPase activity
LEP3755_RS25880	COG3659	wide pore channel activity
LEP3755_RS25890	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
LEP3755_RS25900	COG0596	Alpha beta hydrolase
LEP3755_RS25905	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LEP3755_RS25920	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
LEP3755_RS25925	COG0004	ammonium transporteR
LEP3755_RS25930	COG0004	ammonium transporteR
LEP3755_RS25940	COG0702	epimerase
LEP3755_RS25960	COG1598	PFAM Uncharacterised protein family UPF0150
LEP3755_RS25980	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
LEP3755_RS26025	COG3842	ATPase activity
LEP3755_RS26030	COG1178	ABC-type Fe3 transport system permease component
LEP3755_RS26035	COG2205	protein histidine kinase activity
LEP3755_RS26040	COG1086	Polysaccharide biosynthesis protein
LEP3755_RS26045	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LEP3755_RS26055	COG3266	domain, Protein
LEP3755_RS26055	COG0515	serine threonine protein kinase
LEP3755_RS26065	COG0420	3'-5' exonuclease activity
LEP3755_RS26075	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
LEP3755_RS26085	COG0489	protein tyrosine kinase activity
LEP3755_RS26085	COG3206	protein involved in exopolysaccharide biosynthesis
LEP3755_RS26115	COG2205	protein histidine kinase activity
LEP3755_RS26115	COG2202	Pas domain
LEP3755_RS26140	COG2226	methyltransferase
LEP3755_RS26150	COG5002	protein histidine kinase activity
LEP3755_RS26160	COG1420	regulation of RNA biosynthetic process
LEP3755_RS26180	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
LEP3755_RS26190	COG1028	Short-chain dehydrogenase reductase Sdr
LEP3755_RS26200	COG0640	Transcriptional regulator
LEP3755_RS26205	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
LEP3755_RS26210	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LEP3755_RS26220	COG0431	NADPH-dependent FMN reductase
LEP3755_RS26225	COG0640	Transcriptional regulator
LEP3755_RS26235	COG0336	Belongs to the RNA methyltransferase TrmD family
LEP3755_RS26240	COG4242	Belongs to the peptidase S51 family
LEP3755_RS26245	COG0189	ligase activity
LEP3755_RS26245	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
LEP3755_RS26265	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LEP3755_RS26270	COG2226	methyltransferase
LEP3755_RS26295	COG0791	NLP P60 protein
LEP3755_RS26330	COG1305	Transglutaminase-like
LEP3755_RS26385	COG2815	serine threonine protein kinase
LEP3755_RS26385	COG0515	serine threonine protein kinase
LEP3755_RS26390	COG2133	pyrroloquinoline quinone binding
LEP3755_RS26395	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
LEP3755_RS26410	COG0535	radical SAM domain protein
LEP3755_RS26425	COG1605	Chorismate mutase
LEP3755_RS26425	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
LEP3755_RS26440	COG1505	serine-type exopeptidase activity
LEP3755_RS26445	COG0515	serine threonine protein kinase
LEP3755_RS26455	COG2095	MarC family integral membrane protein
LEP3755_RS26480	COG0222	ribosome binding
LEP3755_RS26485	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
LEP3755_RS26490	COG0081	regulation of translation
LEP3755_RS26495	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
LEP3755_RS26500	COG0250	Participates in transcription elongation, termination and antitermination
LEP3755_RS26505	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
LEP3755_RS26515	COG0335	large ribosomal subunit rRNA binding
LEP3755_RS26530	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
LEP3755_RS26535	COG1122	ATPase activity
LEP3755_RS26540	COG0386	Belongs to the glutathione peroxidase family
LEP3755_RS26555	COG0612	Peptidase, M16
LEP3755_RS26585	COG1047	Peptidyl-prolyl cis-trans
LEP3755_RS26590	COG1233	COG1233 Phytoene dehydrogenase and related
LEP3755_RS26615	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LEP3755_RS26635	COG0714	Associated with various cellular activities
LEP3755_RS26645	COG3552	Protein containing von Willebrand factor type A (VWA) domain
LEP3755_RS26655	COG0473	3-isopropylmalate dehydrogenase activity
LEP3755_RS26665	COG0649	NAD binding
LEP3755_RS26670	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
LEP3755_RS26675	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
LEP3755_RS26685	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
LEP3755_RS26725	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
LEP3755_RS26730	COG0569	domain protein
LEP3755_RS26740	COG0717	Belongs to the dCTP deaminase family
LEP3755_RS26755	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LEP3755_RS26760	COG0598	Magnesium transport protein CorA
LEP3755_RS26785	COG0596	Alpha beta hydrolase
LEP3755_RS26790	COG0542	response to heat
LEP3755_RS26805	COG1867	N(2),N(2)-dimethylguanosine tRNA methyltransferase
LEP3755_RS26830	COG0351	phosphomethylpyrimidine kinase
LEP3755_RS26835	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LEP3755_RS26850	COG0515	serine threonine protein kinase
LEP3755_RS26855	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
LEP3755_RS26855	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
LEP3755_RS26865	COG0538	isocitrate dehydrogenase activity
LEP3755_RS26870	COG0228	four-way junction DNA binding
LEP3755_RS26880	COG1702	phosphate starvation-inducible protein PhoH
LEP3755_RS26890	COG2723	6-phospho-beta-galactosidase activity
LEP3755_RS26910	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LEP3755_RS26920	COG0564	pseudouridine synthase activity
LEP3755_RS26970	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
LEP3755_RS26985	COG0038	chloride channel
LEP3755_RS26995	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LEP3755_RS27000	COG0242	peptide deformylase activity
LEP3755_RS27010	COG1554	hydrolase, family 65, central catalytic
LEP3755_RS27025	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
LEP3755_RS27035	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
LEP3755_RS27040	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
LEP3755_RS27045	COG0750	zinc metalloprotease
LEP3755_RS27060	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
LEP3755_RS27075	COG0237	dephospho-CoA kinase activity
LEP3755_RS27080	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
LEP3755_RS27085	COG1413	lyase activity
LEP3755_RS27090	COG1413	lyase activity
LEP3755_RS27095	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
LEP3755_RS27100	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
LEP3755_RS27110	COG1247	-acetyltransferase
LEP3755_RS27135	COG0517	IMP dehydrogenase activity
LEP3755_RS27135	COG1125	glycine betaine transport
LEP3755_RS27140	COG5001	Diguanylate cyclase
LEP3755_RS27140	COG4251	negative regulation of phosphorylation
LEP3755_RS27140	COG3706	GGDEF domain
LEP3755_RS27140	COG2203	Gaf domain
LEP3755_RS27165	COG0861	Integral membrane protein TerC family
LEP3755_RS27170	COG0105	UTP biosynthetic process
LEP3755_RS27175	COG1166	arginine decarboxylase activity
LEP3755_RS27195	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LEP3755_RS27225	COG0156	8-amino-7-oxononanoate synthase activity
LEP3755_RS27235	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
LEP3755_RS27265	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LEP3755_RS27300	COG1376	ErfK ybiS ycfS ynhG family protein
LEP3755_RS27310	COG1595	DNA-templated transcription, initiation
LEP3755_RS27345	COG1137	ATPase activity
LEP3755_RS27370	COG3850	Histidine kinase
LEP3755_RS27370	COG2205	protein histidine kinase activity
LEP3755_RS27370	COG4999	Histidine kinase
LEP3755_RS27370	COG3437	response regulator, receiver
LEP3755_RS27395	COG0824	Thioesterase
LEP3755_RS27400	COG0024	Methionine aminopeptidase
LEP3755_RS27415	COG0793	Belongs to the peptidase S41A family
LEP3755_RS27420	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
LEP3755_RS27440	COG0589	response to stress
LEP3755_RS27445	COG0126	phosphoglycerate kinase activity
LEP3755_RS27455	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
LEP3755_RS27495	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
LEP3755_RS27500	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LEP3755_RS27525	COG3629	intracellular signal transduction
LEP3755_RS27525	COG3903	Transcriptional regulator
LEP3755_RS27535	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
LEP3755_RS27540	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
LEP3755_RS27630	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
LEP3755_RS27635	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
LEP3755_RS27640	COG1234	tRNA 3'-trailer cleavage
LEP3755_RS27665	COG3621	Patatin-like phospholipase
LEP3755_RS27670	COG0531	amino acid
LEP3755_RS27700	COG0596	Alpha beta hydrolase
LEP3755_RS27715	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
LEP3755_RS27715	COG0678	peroxiredoxin activity
LEP3755_RS27720	COG0784	Response regulator, receiver
LEP3755_RS27720	COG0643	Histidine kinase
LEP3755_RS27720	COG2198	Histidine kinase
LEP3755_RS27725	COG0840	transmembrane signaling receptor activity
LEP3755_RS27725	COG2203	Gaf domain
LEP3755_RS27740	COG2203	Gaf domain
LEP3755_RS27740	COG0840	transmembrane signaling receptor activity
LEP3755_RS27755	COG0784	Response regulator, receiver
LEP3755_RS27760	COG1309	transcriptional regulator
LEP3755_RS27770	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
LEP3755_RS27780	COG0768	penicillin binding
LEP3755_RS27785	COG0436	Aminotransferase
LEP3755_RS27795	COG0297	glycogen (starch) synthase activity
LEP3755_RS27800	COG1164	Oligoendopeptidase f
LEP3755_RS27805	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LEP3755_RS27835	COG1132	(ABC) transporter
LEP3755_RS27845	COG0438	transferase activity, transferring glycosyl groups
LEP3755_RS27855	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LEP3755_RS27880	COG4242	Belongs to the peptidase S51 family
LEP3755_RS27890	COG0189	ligase activity
LEP3755_RS27890	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
LEP3755_RS27910	COG0439	Biotin carboxylase
LEP3755_RS27930	COG0515	serine threonine protein kinase
LEP3755_RS27960	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
LEP3755_RS27975	COG0134	indole-3-glycerol-phosphate synthase activity
LEP3755_RS27980	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LEP3755_RS28030	COG0443	Heat shock 70 kDa protein
LEP3755_RS28040	COG0492	ferredoxin-NADP+ reductase activity
LEP3755_RS28065	COG1131	(ABC) transporter
LEP3755_RS28070	COG3268	Saccharopine dehydrogenase
LEP3755_RS28075	COG0116	Belongs to the methyltransferase superfamily
LEP3755_RS28085	COG1543	Belongs to the glycosyl hydrolase 57 family
LEP3755_RS28100	COG0438	transferase activity, transferring glycosyl groups
LEP3755_RS28105	COG2205	protein histidine kinase activity
LEP3755_RS28105	COG0784	Response regulator, receiver
LEP3755_RS28120	COG0438	transferase activity, transferring glycosyl groups
LEP3755_RS28140	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LEP3755_RS28145	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
LEP3755_RS28155	COG0588	phosphoglycerate mutase activity
LEP3755_RS28170	COG2202	Pas domain
LEP3755_RS28170	COG2205	protein histidine kinase activity
LEP3755_RS28175	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
LEP3755_RS28185	COG4166	transmembrane transport
LEP3755_RS28190	COG1691	(AIR) carboxylase
LEP3755_RS28195	COG1104	cysteine desulfurase activity
LEP3755_RS28200	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LEP3755_RS28240	COG1666	GTP binding
LEP3755_RS28245	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
LEP3755_RS28250	COG0583	DNA-binding transcription factor activity
LEP3755_RS28255	COG1049	propionate catabolic process, 2-methylcitrate cycle
LEP3755_RS28265	COG3507	Belongs to the glycosyl hydrolase 43 family
LEP3755_RS28270	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
LEP3755_RS28320	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
LEP3755_RS28325	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
LEP3755_RS28340	COG2234	aminopeptidase activity
LEP3755_RS28345	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
LEP3755_RS28350	COG2211	Major facilitator Superfamily
LEP3755_RS28355	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
LEP3755_RS28365	COG0702	epimerase
LEP3755_RS28380	COG0745	RESPONSE REGULATOR receiver
LEP3755_RS28425	COG1085	galactose-1-phosphate uridylyltransferase
LEP3755_RS28430	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LEP3755_RS28440	COG3250	beta-galactosidase activity
LEP3755_RS28445	COG0246	Mannitol dehydrogenase
LEP3755_RS28450	COG0546	phosphoglycolate phosphatase activity
LEP3755_RS28475	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LEP3755_RS28495	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
LEP3755_RS28500	COG1268	BioY protein
LEP3755_RS28505	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
LEP3755_RS28510	COG0391	Required for morphogenesis under gluconeogenic growth conditions
LEP3755_RS28515	COG0802	atpase or kinase
LEP3755_RS28520	COG1252	NADH dehydrogenase
LEP3755_RS28530	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
LEP3755_RS28565	COG0539	negative regulation of cytoplasmic translation
LEP3755_RS28575	COG0745	RESPONSE REGULATOR receiver
LEP3755_RS28580	COG0739	heme binding
LEP3755_RS28585	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
LEP3755_RS28595	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LEP3755_RS28600	COG0515	serine threonine protein kinase
LEP3755_RS28600	COG3266	domain, Protein
LEP3755_RS28605	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
LEP3755_RS28610	COG2337	Toxic component of a toxin-antitoxin (TA) module
LEP3755_RS28625	COG0667	Aldo Keto reductase
LEP3755_RS28635	COG1070	Carbohydrate kinase
LEP3755_RS28650	COG3932	Exopolysaccharide synthesis, ExoD
LEP3755_RS28655	COG1597	lipid kinase activity
LEP3755_RS28655	COG1803	Methylglyoxal synthase
LEP3755_RS28685	COG2885	chlorophyll binding
LEP3755_RS28690	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LEP3755_RS28710	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
LEP3755_RS28715	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LEP3755_RS28715	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LEP3755_RS28720	COG5002	protein histidine kinase activity
LEP3755_RS28725	COG0151	Belongs to the GarS family
LEP3755_RS28740	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
LEP3755_RS28780	COG0667	Aldo Keto reductase
LEP3755_RS28785	COG1116	anion transmembrane transporter activity
LEP3755_RS28790	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LEP3755_RS28805	COG0534	Mate efflux family protein
LEP3755_RS28810	COG0475	glutathione-regulated potassium exporter activity
LEP3755_RS28820	COG1136	(ABC) transporter
LEP3755_RS28820	COG0577	efflux transmembrane transporter activity
LEP3755_RS28830	COG1131	(ABC) transporter
LEP3755_RS28860	COG1595	DNA-templated transcription, initiation
LEP3755_RS28870	COG1136	(ABC) transporter
LEP3755_RS28880	COG4585	Histidine kinase
LEP3755_RS28885	COG2197	response regulator
LEP3755_RS28905	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
LEP3755_RS28930	COG0542	response to heat
LEP3755_RS28940	COG0724	RNA recognition motif
LEP3755_RS28945	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
LEP3755_RS28950	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LEP3755_RS28975	COG1902	pentaerythritol trinitrate reductase activity
LEP3755_RS28980	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
LEP3755_RS28990	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LEP3755_RS28995	COG2267	carboxylic ester hydrolase activity
LEP3755_RS29000	COG1028	Short-chain dehydrogenase reductase Sdr
LEP3755_RS29015	COG0277	FAD linked oxidase domain protein
LEP3755_RS29025	COG1028	Short-chain dehydrogenase reductase Sdr
LEP3755_RS29030	COG2249	NAD(P)H dehydrogenase (quinone) activity
LEP3755_RS29040	COG1309	transcriptional regulator
LEP3755_RS29055	COG2197	response regulator
LEP3755_RS29060	COG2815	serine threonine protein kinase
LEP3755_RS29060	COG0515	serine threonine protein kinase
LEP3755_RS29065	COG2267	carboxylic ester hydrolase activity
LEP3755_RS29115	COG1917	Cupin 2, conserved barrel domain protein
LEP3755_RS29115	COG4977	sequence-specific DNA binding
LEP3755_RS29120	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
LEP3755_RS29120	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LEP3755_RS29125	COG2197	response regulator
LEP3755_RS29130	COG4585	Histidine kinase
LEP3755_RS29145	COG4585	Histidine kinase
LEP3755_RS29150	COG2815	serine threonine protein kinase
LEP3755_RS29150	COG0515	serine threonine protein kinase
LEP3755_RS29185	COG2258	MOSC domain
LEP3755_RS29195	COG2258	MOSC domain
LEP3755_RS29225	COG4974	Belongs to the 'phage' integrase family
LEP3755_RS29285	COG1595	DNA-templated transcription, initiation
LEP3755_RS29295	COG5002	protein histidine kinase activity
LEP3755_RS29295	COG0784	Response regulator, receiver
LEP3755_RS29305	COG1595	DNA-templated transcription, initiation
LEP3755_RS29320	COG4251	negative regulation of phosphorylation
LEP3755_RS29330	COG5002	protein histidine kinase activity
LEP3755_RS29365	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LEP3755_RS29395	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
LEP3755_RS29405	COG2385	sporulation resulting in formation of a cellular spore
LEP3755_RS29415	COG0783	Belongs to the Dps family
LEP3755_RS29435	COG0393	Putative heavy-metal-binding
LEP3755_RS29450	COG0315	cyclic pyranopterin monophosphate synthase activity
LEP3755_RS29460	COG0483	inositol monophosphate 1-phosphatase activity
LEP3755_RS29475	COG0644	oxidoreductase
LEP3755_RS29495	COG2189	Belongs to the N(4) N(6)-methyltransferase family
LEP3755_RS29505	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
LEP3755_RS29510	COG1381	Involved in DNA repair and RecF pathway recombination
LEP3755_RS29520	COG0438	transferase activity, transferring glycosyl groups
LEP3755_RS29525	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
LEP3755_RS29530	COG1045	serine acetyltransferase
LEP3755_RS29550	COG0443	Heat shock 70 kDa protein
LEP3755_RS29575	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LEP3755_RS29585	COG0745	RESPONSE REGULATOR receiver
LEP3755_RS29590	COG2201	protein-glutamate methylesterase activity
LEP3755_RS29620	COG3264	Mechanosensitive ion channel
LEP3755_RS29620	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
LEP3755_RS29650	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
LEP3755_RS29655	COG0514	ATP-dependent DNA helicase (RecQ)
LEP3755_RS29660	COG1028	Short-chain dehydrogenase reductase Sdr
LEP3755_RS29670	COG0693	protein deglycase activity
LEP3755_RS29700	COG0009	L-threonylcarbamoyladenylate synthase
LEP3755_RS29705	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
LEP3755_RS29735	COG5002	protein histidine kinase activity
LEP3755_RS29735	COG5000	phosphorelay sensor kinase activity
LEP3755_RS29750	COG0542	response to heat
LEP3755_RS29765	COG1429	ligase activity, forming nitrogen-metal bonds
LEP3755_RS29805	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
LEP3755_RS29810	COG2205	protein histidine kinase activity
LEP3755_RS29835	COG3631	Ketosteroid isomerase-related protein
LEP3755_RS29840	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
LEP3755_RS29845	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
LEP3755_RS29885	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
LEP3755_RS29910	COG0596	Alpha beta hydrolase
LEP3755_RS29925	COG2203	Gaf domain
LEP3755_RS29925	COG5001	Diguanylate cyclase
LEP3755_RS29925	COG3706	GGDEF domain
LEP3755_RS29925	COG4251	negative regulation of phosphorylation
LEP3755_RS29930	COG3437	response regulator, receiver
LEP3755_RS29930	COG2205	protein histidine kinase activity
LEP3755_RS29930	COG4999	Histidine kinase
LEP3755_RS29930	COG3850	Histidine kinase
LEP3755_RS29935	COG1803	Methylglyoxal synthase
LEP3755_RS29935	COG1597	lipid kinase activity
LEP3755_RS29945	COG0745	RESPONSE REGULATOR receiver
LEP3755_RS29950	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
LEP3755_RS29960	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LEP3755_RS29980	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LEP3755_RS30005	COG2205	protein histidine kinase activity
LEP3755_RS30010	COG1187	pseudouridine synthase activity
LEP3755_RS30040	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
LEP3755_RS30045	COG0784	Response regulator, receiver
LEP3755_RS30050	COG4251	negative regulation of phosphorylation
LEP3755_RS30055	COG0784	Response regulator, receiver
LEP3755_RS30065	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LEP3755_RS30075	COG2308	Evidence 4 Homologs of previously reported genes of
LEP3755_RS30085	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
LEP3755_RS30090	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
LEP3755_RS30100	COG2124	cytochrome p450
LEP3755_RS30105	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
LEP3755_RS30115	COG0792	nuclease activity
LEP3755_RS30125	COG0745	RESPONSE REGULATOR receiver
LEP3755_RS30130	COG5002	protein histidine kinase activity
LEP3755_RS30135	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LEP3755_RS30155	COG1032	radical SAM domain protein
LEP3755_RS30175	COG0357	Ribosomal RNA small subunit methyltransferase G
LEP3755_RS30180	COG1122	ATPase activity
LEP3755_RS30200	COG0137	argininosuccinate synthase activity
LEP3755_RS30205	COG1216	Glycosyl transferase, family 2
LEP3755_RS30230	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
LEP3755_RS30275	COG0612	Peptidase, M16
LEP3755_RS30280	COG0612	Peptidase, M16
LEP3755_RS30295	COG0194	GDP metabolic process
LEP3755_RS30300	COG2052	Domain of unknown function (DUF370)
LEP3755_RS30315	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
LEP3755_RS30325	COG0322	excinuclease ABC activity
LEP3755_RS30330	COG0072	phenylalanine-tRNA ligase activity
LEP3755_RS30330	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LEP3755_RS30340	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
LEP3755_RS30345	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
LEP3755_RS30360	COG0673	inositol 2-dehydrogenase activity
LEP3755_RS30365	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
LEP3755_RS30390	COG0033	Phosphoglucomutase
LEP3755_RS30400	COG0625	glutathione transferase activity
LEP3755_RS30415	COG2337	Toxic component of a toxin-antitoxin (TA) module
LEP3755_RS30420	COG0343	queuine tRNA-ribosyltransferase activity
LEP3755_RS30425	COG1121	(ABC) transporter
LEP3755_RS30430	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LEP3755_RS30440	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LEP3755_RS30465	COG0438	transferase activity, transferring glycosyl groups
LEP3755_RS30470	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
LEP3755_RS30490	COG3507	Belongs to the glycosyl hydrolase 43 family
LEP3755_RS30490	COG3693	PFAM glycoside hydrolase, family 10
LEP3755_RS30490	COG2382	esterase
LEP3755_RS30500	COG2205	protein histidine kinase activity
LEP3755_RS30515	COG4249	Peptidase C14 caspase catalytic subunit p20
LEP3755_RS30515	COG2319	Wd-40 repeat
LEP3755_RS30520	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LEP3755_RS30540	COG3038	cytochrome b561
LEP3755_RS30555	COG1215	transferase activity, transferring glycosyl groups
LEP3755_RS30585	COG1662	PFAM IS1 transposase
LEP3755_RS30600	COG1598	PFAM Uncharacterised protein family UPF0150
LEP3755_RS30615	COG0752	glycyl-tRNA synthetase alpha subunit
LEP3755_RS31010	COG3291	Pkd domain containing protein
LEP3755_RS31175	COG5002	protein histidine kinase activity
LEP3755_RS32240	COG3409	Peptidoglycan-binding domain 1 protein
LEP3755_RS32240	COG3429	Glucose-6-phosphate dehydrogenase subunit
LEP3755_RS32590	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
LEP3755_RS32665	COG0174	glutamine synthetase
LEP3755_RS32755	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
LEP3755_RS32870	COG4948	Mandelate Racemase Muconate Lactonizing