locus-tag	class	description
LEPBI_RS00040	COG0187	DNA topoisomerase II activity
LEPBI_RS00050	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LEPBI_RS00095	COG1028	Short-chain dehydrogenase reductase Sdr
LEPBI_RS00100	COG0009	L-threonylcarbamoyladenylate synthase
LEPBI_RS00115	COG0557	exoribonuclease II activity
LEPBI_RS00125	COG0802	atpase or kinase
LEPBI_RS00130	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
LEPBI_RS00135	COG1874	Beta-galactosidase
LEPBI_RS00150	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
LEPBI_RS00180	COG1045	serine acetyltransferase
LEPBI_RS00200	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
LEPBI_RS00230	COG3384	dioxygenase
LEPBI_RS00245	COG2826	transposase and inactivated derivatives, IS30 family
LEPBI_RS00250	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
LEPBI_RS00255	COG1028	Short-chain dehydrogenase reductase Sdr
LEPBI_RS00290	COG1960	acyl-CoA dehydrogenase activity
LEPBI_RS00295	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
LEPBI_RS00295	COG0512	Glutamine amidotransferase of anthranilate synthase
LEPBI_RS00300	COG1132	(ABC) transporter
LEPBI_RS00340	COG1262	PFAM Formylglycine-generating sulfatase enzyme
LEPBI_RS00345	COG1846	Transcriptional regulator
LEPBI_RS00365	COG1366	Belongs to the anti-sigma-factor antagonist family
LEPBI_RS00370	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
LEPBI_RS00385	COG3178	'Phosphotransferase
LEPBI_RS00390	COG4191	Histidine kinase
LEPBI_RS00395	COG3852	Histidine kinase
LEPBI_RS00410	COG0784	Response regulator, receiver
LEPBI_RS00420	COG0142	geranyltranstransferase activity
LEPBI_RS00430	COG0475	glutathione-regulated potassium exporter activity
LEPBI_RS00465	COG0167	dihydroorotate dehydrogenase activity
LEPBI_RS00470	COG4191	Histidine kinase
LEPBI_RS00480	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LEPBI_RS00485	COG0564	pseudouridine synthase activity
LEPBI_RS00500	COG2200	EAL domain
LEPBI_RS00505	COG1309	transcriptional regulator
LEPBI_RS00515	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
LEPBI_RS00520	COG0385	Bile acid
LEPBI_RS00525	COG1960	acyl-CoA dehydrogenase activity
LEPBI_RS00530	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LEPBI_RS00535	COG0300	oxidoreductase activity
LEPBI_RS00545	COG1024	Enoyl-CoA hydratase
LEPBI_RS00550	COG0840	transmembrane signaling receptor activity
LEPBI_RS00575	COG0385	Bile acid
LEPBI_RS00585	COG5278	phosphoserine phosphatase activity
LEPBI_RS00585	COG0840	transmembrane signaling receptor activity
LEPBI_RS00610	COG4682	membrane
LEPBI_RS00635	COG1028	Short-chain dehydrogenase reductase Sdr
LEPBI_RS00640	COG2207	Transcriptional regulator
LEPBI_RS00680	COG1360	Flagellar Motor Protein
LEPBI_RS00700	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
LEPBI_RS00705	COG0280	phosphate acetyltransferase
LEPBI_RS00705	COG0281	malic enzyme
LEPBI_RS00725	COG0848	biopolymer transport protein
LEPBI_RS00735	COG0811	peptide transport
LEPBI_RS00745	COG0569	domain protein
LEPBI_RS00750	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
LEPBI_RS00760	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
LEPBI_RS00810	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
LEPBI_RS00825	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LEPBI_RS00835	COG2304	oxidoreductase activity
LEPBI_RS00840	COG0494	nUDIX hydrolase
LEPBI_RS00845	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
LEPBI_RS00850	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
LEPBI_RS00855	COG0720	synthase
LEPBI_RS00905	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
LEPBI_RS00920	COG0527	aspartate kinase activity
LEPBI_RS00945	COG1063	alcohol dehydrogenase
LEPBI_RS00970	COG1360	Flagellar Motor Protein
LEPBI_RS00975	COG1580	Controls the rotational direction of flagella during chemotaxis
LEPBI_RS01000	COG2274	protein secretion by the type I secretion system
LEPBI_RS01030	COG1028	Short-chain dehydrogenase reductase Sdr
LEPBI_RS01035	COG2340	Cysteine-rich secretory protein family
LEPBI_RS01045	COG0640	Transcriptional regulator
LEPBI_RS01075	COG2949	membrane
LEPBI_RS01105	COG0697	spore germination
LEPBI_RS01120	COG0471	metal ion transport
LEPBI_RS01145	COG0193	aminoacyl-tRNA hydrolase activity
LEPBI_RS01205	COG2072	flavoprotein involved in K transport
LEPBI_RS01210	COG1408	metallophosphoesterase
LEPBI_RS01260	COG0768	penicillin binding
LEPBI_RS01275	COG1639	'signal transduction protein
LEPBI_RS01300	COG1136	(ABC) transporter
LEPBI_RS01315	COG1484	DNA-dependent DNA replication
LEPBI_RS01320	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
LEPBI_RS01330	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LEPBI_RS01340	COG0488	(ABC) transporter
LEPBI_RS01370	COG2199	diguanylate cyclase activity
LEPBI_RS01370	COG3287	FIST C domain
LEPBI_RS01370	COG2200	EAL domain
LEPBI_RS01420	COG1847	R3H domain protein
LEPBI_RS01440	COG1309	transcriptional regulator
LEPBI_RS01465	COG1607	acyl-coa hydrolase
LEPBI_RS01480	COG2814	Major facilitator Superfamily
LEPBI_RS01505	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LEPBI_RS01510	COG0514	ATP-dependent DNA helicase (RecQ)
LEPBI_RS01515	COG1696	Membrane protein involved in D-alanine export
LEPBI_RS01545	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
LEPBI_RS01595	COG4174	ABC transporter (Permease)
LEPBI_RS01600	COG4239	(ABC) transporter, permease
LEPBI_RS01605	COG0444	Belongs to the ABC transporter superfamily
LEPBI_RS01610	COG4608	Belongs to the ABC transporter superfamily
LEPBI_RS01630	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
LEPBI_RS01645	COG1022	Amp-dependent synthetase and ligase
LEPBI_RS01670	COG0024	Methionine aminopeptidase
LEPBI_RS01705	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
LEPBI_RS01715	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LEPBI_RS01720	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LEPBI_RS01735	COG0183	Belongs to the thiolase family
LEPBI_RS01745	COG2274	protein secretion by the type I secretion system
LEPBI_RS01750	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LEPBI_RS01755	COG2274	protein secretion by the type I secretion system
LEPBI_RS01780	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
LEPBI_RS01790	COG0456	acetyltransferase
LEPBI_RS01810	COG1695	Transcriptional regulator
LEPBI_RS01850	COG1121	(ABC) transporter
LEPBI_RS01880	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
LEPBI_RS01915	COG0826	peptidase U32
LEPBI_RS01930	COG0745	RESPONSE REGULATOR receiver
LEPBI_RS01935	COG2205	protein histidine kinase activity
LEPBI_RS01940	COG4452	Inner membrane protein CreD
LEPBI_RS01955	COG5002	protein histidine kinase activity
LEPBI_RS01955	COG2198	Histidine kinase
LEPBI_RS01955	COG0784	Response regulator, receiver
LEPBI_RS01985	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
LEPBI_RS02050	COG0840	transmembrane signaling receptor activity
LEPBI_RS02050	COG3290	protein histidine kinase activity
LEPBI_RS02060	COG2198	Histidine kinase
LEPBI_RS02060	COG0784	Response regulator, receiver
LEPBI_RS02060	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LEPBI_RS02060	COG2205	protein histidine kinase activity
LEPBI_RS02075	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
LEPBI_RS02080	COG0640	Transcriptional regulator
LEPBI_RS02170	COG1077	Cell shape determining protein MreB Mrl
LEPBI_RS02185	COG2814	Major facilitator Superfamily
LEPBI_RS02195	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
LEPBI_RS02205	COG3263	regulation of cellular component size
LEPBI_RS02210	COG0833	amino acid
LEPBI_RS02260	COG0840	transmembrane signaling receptor activity
LEPBI_RS02260	COG5278	phosphoserine phosphatase activity
LEPBI_RS02275	COG3852	Histidine kinase
LEPBI_RS02305	COG4974	Belongs to the 'phage' integrase family
LEPBI_RS02315	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
LEPBI_RS02320	COG0793	Belongs to the peptidase S41A family
LEPBI_RS02360	COG0835	chemotaxis
LEPBI_RS02365	COG0704	Plays a role in the regulation of phosphate uptake
LEPBI_RS02415	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
LEPBI_RS02425	COG1366	Belongs to the anti-sigma-factor antagonist family
LEPBI_RS02445	COG4206	TonB-dependent receptor
LEPBI_RS02450	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LEPBI_RS02460	COG5002	protein histidine kinase activity
LEPBI_RS02490	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LEPBI_RS02530	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LEPBI_RS02535	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LEPBI_RS02550	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LEPBI_RS02555	COG1366	Belongs to the anti-sigma-factor antagonist family
LEPBI_RS02560	COG0693	protein deglycase activity
LEPBI_RS02565	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LEPBI_RS02590	COG2166	iron-sulfur cluster assembly
LEPBI_RS02620	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LEPBI_RS02640	COG0277	FAD linked oxidase domain protein
LEPBI_RS02645	COG1028	Short-chain dehydrogenase reductase Sdr
LEPBI_RS02655	COG1696	Membrane protein involved in D-alanine export
LEPBI_RS02735	COG4770	biotin carboxylase activity
LEPBI_RS02740	COG0511	ligase activity, forming carbon-carbon bonds
LEPBI_RS02740	COG5016	pyruvate
LEPBI_RS02765	COG0037	tRNA processing
LEPBI_RS02785	COG0352	thiamine-phosphate diphosphorylase activity
LEPBI_RS02785	COG0351	phosphomethylpyrimidine kinase
LEPBI_RS02840	COG0277	FAD linked oxidase domain protein
LEPBI_RS02845	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
LEPBI_RS02850	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
LEPBI_RS02865	COG1011	Hydrolase
LEPBI_RS02910	COG2211	Major facilitator Superfamily
LEPBI_RS02925	COG0840	transmembrane signaling receptor activity
LEPBI_RS02940	COG0183	Belongs to the thiolase family
LEPBI_RS02945	COG1250	3-hydroxyacyl-CoA dehydrogenase
LEPBI_RS02970	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LEPBI_RS02975	COG0028	Belongs to the TPP enzyme family
LEPBI_RS03030	COG1695	Transcriptional regulator
LEPBI_RS03035	COG4191	Histidine kinase
LEPBI_RS03035	COG4191	Histidine kinase
LEPBI_RS03040	COG4335	DNA alkylation repair
LEPBI_RS03060	COG4221	oxidoreductase activity
LEPBI_RS03080	COG0739	heme binding
LEPBI_RS03115	COG0386	Belongs to the glutathione peroxidase family
LEPBI_RS03125	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
LEPBI_RS03150	COG2361	Protein of unknown function DUF86
LEPBI_RS03170	COG3959	Transketolase, thiamine diphosphate binding domain
LEPBI_RS03185	COG3852	Histidine kinase
LEPBI_RS03185	COG3852	Histidine kinase
LEPBI_RS03195	COG0038	chloride channel
LEPBI_RS03200	COG4067	protein conserved in archaea
LEPBI_RS03200	COG0189	ligase activity
LEPBI_RS03220	COG3956	TIGRFAM MazG family protein
LEPBI_RS03240	COG2259	Doxx family
LEPBI_RS03265	COG0657	acetylesterase activity
LEPBI_RS03295	COG5398	heme oxygenase
LEPBI_RS03315	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LEPBI_RS03315	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LEPBI_RS03320	COG0438	transferase activity, transferring glycosyl groups
LEPBI_RS03345	COG0187	DNA topoisomerase II activity
LEPBI_RS03375	COG4399	Belongs to the UPF0754 family
LEPBI_RS03380	COG1028	Short-chain dehydrogenase reductase Sdr
LEPBI_RS03385	COG0456	acetyltransferase
LEPBI_RS03400	COG0530	calcium, potassium:sodium antiporter activity
LEPBI_RS03420	COG3977	Valine--pyruvate aminotransferase
LEPBI_RS03425	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
LEPBI_RS03450	COG0739	heme binding
LEPBI_RS03455	COG0739	heme binding
LEPBI_RS03485	COG0183	Belongs to the thiolase family
LEPBI_RS03515	COG2208	phosphoserine phosphatase activity
LEPBI_RS03520	COG0488	(ABC) transporter
LEPBI_RS03535	COG1253	flavin adenine dinucleotide binding
LEPBI_RS03540	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
LEPBI_RS03545	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
LEPBI_RS03560	COG0156	8-amino-7-oxononanoate synthase activity
LEPBI_RS03570	COG1138	Cytochrome C-type biogenesis protein
LEPBI_RS03575	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
LEPBI_RS03600	COG2986	histidine ammonia-lyase
LEPBI_RS03610	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LEPBI_RS03625	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
LEPBI_RS03645	COG1766	The M ring may be actively involved in energy transduction
LEPBI_RS03660	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
LEPBI_RS03665	COG1309	transcriptional regulator
LEPBI_RS03675	COG1070	Carbohydrate kinase
LEPBI_RS03685	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
LEPBI_RS03710	COG1815	bacterial-type flagellum-dependent cell motility
LEPBI_RS03715	COG1061	Type III restriction enzyme res subunit
LEPBI_RS03730	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LEPBI_RS03735	COG1127	ABC transporter
LEPBI_RS03760	COG2081	HI0933 family
LEPBI_RS03770	COG0123	including yeast histone deacetylase and acetoin utilization protein
LEPBI_RS03800	COG3345	alpha-galactosidase
LEPBI_RS03805	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
LEPBI_RS03810	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
LEPBI_RS03845	COG0123	including yeast histone deacetylase and acetoin utilization protein
LEPBI_RS03870	COG2030	dehydratase
LEPBI_RS03890	COG0681	Belongs to the peptidase S26 family
LEPBI_RS03900	COG0028	Belongs to the TPP enzyme family
LEPBI_RS03905	COG0347	Belongs to the P(II) protein family
LEPBI_RS03910	COG0004	ammonium transporteR
LEPBI_RS03915	COG0386	Belongs to the glutathione peroxidase family
LEPBI_RS03920	COG1846	Transcriptional regulator
LEPBI_RS03930	COG0356	it plays a direct role in the translocation of protons across the membrane
LEPBI_RS03935	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LEPBI_RS04015	COG2154	pterin-4-alpha-carbinolamine dehydratase
LEPBI_RS04025	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
LEPBI_RS04035	COG0697	spore germination
LEPBI_RS04040	COG0628	permease
LEPBI_RS04055	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
LEPBI_RS04080	COG0560	Phosphoserine phosphatase
LEPBI_RS04080	COG3830	Belongs to the UPF0237 family
LEPBI_RS04100	COG0285	dihydrofolate synthase activity
LEPBI_RS04130	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
LEPBI_RS04130	COG0539	negative regulation of cytoplasmic translation
LEPBI_RS04130	COG1185	polyribonucleotide nucleotidyltransferase activity
LEPBI_RS04135	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
LEPBI_RS04165	COG1132	(ABC) transporter
LEPBI_RS04175	COG0427	acetyl-CoA hydrolase
LEPBI_RS04205	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LEPBI_RS04225	COG5002	protein histidine kinase activity
LEPBI_RS04230	COG1196	nuclear chromosome segregation
LEPBI_RS04230	COG0741	lytic transglycosylase activity
LEPBI_RS04230	COG0739	heme binding
LEPBI_RS04260	COG1024	Enoyl-CoA hydratase
LEPBI_RS04295	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
LEPBI_RS04295	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LEPBI_RS04300	COG2089	acid synthase
LEPBI_RS04340	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
LEPBI_RS04350	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
LEPBI_RS04400	COG0543	2 iron, 2 sulfur cluster binding
LEPBI_RS04400	COG0633	Ferredoxin
LEPBI_RS04430	COG1757	Na H antiporter
LEPBI_RS04455	COG0823	Involved in the tonB-independent uptake of proteins
LEPBI_RS04455	COG4946	Tricorn protease homolog
LEPBI_RS04455	COG1506	peptidase
LEPBI_RS04470	COG0436	Aminotransferase
LEPBI_RS04485	COG3852	Histidine kinase
LEPBI_RS04495	COG0745	RESPONSE REGULATOR receiver
LEPBI_RS04500	COG5002	protein histidine kinase activity
LEPBI_RS04505	COG2201	protein-glutamate methylesterase activity
LEPBI_RS04510	COG0643	Histidine kinase
LEPBI_RS04510	COG2198	Histidine kinase
LEPBI_RS04515	COG0835	chemotaxis
LEPBI_RS04545	COG1024	Enoyl-CoA hydratase
LEPBI_RS04555	COG0058	SHG alpha-glucan phosphorylase activity
LEPBI_RS04595	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
LEPBI_RS04600	COG4232	protein-disulfide reductase activity
LEPBI_RS04640	COG1191	sigma factor activity
LEPBI_RS04665	COG0194	GDP metabolic process
LEPBI_RS04680	COG0784	Response regulator, receiver
LEPBI_RS04680	COG2205	protein histidine kinase activity
LEPBI_RS04705	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LEPBI_RS04715	COG1472	Belongs to the glycosyl hydrolase 3 family
LEPBI_RS04740	COG2755	lipolytic protein G-D-S-L family
LEPBI_RS04780	COG0805	protein transport
LEPBI_RS04790	COG0745	RESPONSE REGULATOR receiver
LEPBI_RS04805	COG1999	signal sequence binding
LEPBI_RS04810	COG0339	signal peptide processing
LEPBI_RS04815	COG3011	Protein conserved in bacteria
LEPBI_RS04950	COG0095	Lipoate-protein ligase
LEPBI_RS04985	COG0616	signal peptide processing
LEPBI_RS05005	COG1611	Belongs to the LOG family
LEPBI_RS05020	COG0109	protoheme IX farnesyltransferase activity
LEPBI_RS05025	COG0163	prenyltransferase activity
LEPBI_RS05030	COG1607	acyl-coa hydrolase
LEPBI_RS05065	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
LEPBI_RS05075	COG0822	iron-sulfur transferase activity
LEPBI_RS05105	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LEPBI_RS05145	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
LEPBI_RS05190	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LEPBI_RS05195	COG0508	dehydrogenase complex catalyzes the overall conversion of
LEPBI_RS05200	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
LEPBI_RS05230	COG1262	PFAM Formylglycine-generating sulfatase enzyme
LEPBI_RS05250	COG5002	protein histidine kinase activity
LEPBI_RS05250	COG2198	Histidine kinase
LEPBI_RS05250	COG0784	Response regulator, receiver
LEPBI_RS05255	COG1595	DNA-templated transcription, initiation
LEPBI_RS05270	COG0579	oxidoreductase
LEPBI_RS05275	COG1408	metallophosphoesterase
LEPBI_RS05280	COG0840	transmembrane signaling receptor activity
LEPBI_RS05340	COG3279	Response regulator of the LytR AlgR family
LEPBI_RS05410	COG1309	transcriptional regulator
LEPBI_RS05445	COG1022	Amp-dependent synthetase and ligase
LEPBI_RS05450	COG1960	acyl-CoA dehydrogenase activity
LEPBI_RS05460	COG2030	dehydratase
LEPBI_RS05480	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
LEPBI_RS05495	COG1396	sequence-specific DNA binding
LEPBI_RS05510	COG0739	heme binding
LEPBI_RS05525	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
LEPBI_RS05550	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
LEPBI_RS05555	COG2086	electron transfer activity
LEPBI_RS05580	COG1960	acyl-CoA dehydrogenase activity
LEPBI_RS05585	COG1233	COG1233 Phytoene dehydrogenase and related
LEPBI_RS05590	COG0083	homoserine kinase activity
LEPBI_RS05605	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
LEPBI_RS05605	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LEPBI_RS05615	COG0596	Alpha beta hydrolase
LEPBI_RS05620	COG1846	Transcriptional regulator
LEPBI_RS05635	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LEPBI_RS05645	COG0402	S-adenosylhomocysteine deaminase activity
LEPBI_RS05660	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
LEPBI_RS05705	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LEPBI_RS05715	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
LEPBI_RS05720	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LEPBI_RS05725	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
LEPBI_RS05735	COG0113	porphobilinogen synthase activity
LEPBI_RS05740	COG0181	hydroxymethylbilane synthase activity
LEPBI_RS05780	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LEPBI_RS05780	COG1648	precorrin-2 dehydrogenase activity
LEPBI_RS05785	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
LEPBI_RS05805	COG0175	sulfate reduction
LEPBI_RS05815	COG4208	sulfate ABC transporter
LEPBI_RS05825	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
LEPBI_RS05840	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
LEPBI_RS05860	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
LEPBI_RS05865	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
LEPBI_RS05875	COG1366	Belongs to the anti-sigma-factor antagonist family
LEPBI_RS05885	COG5002	protein histidine kinase activity
LEPBI_RS05890	COG5002	protein histidine kinase activity
LEPBI_RS05910	COG4974	Belongs to the 'phage' integrase family
LEPBI_RS05925	COG1858	cytochrome C peroxidase
LEPBI_RS05940	COG3548	integral membrane protein
LEPBI_RS05960	COG2963	transposase activity
LEPBI_RS05965	COG2801	Transposase and inactivated derivatives
LEPBI_RS06025	COG0066	3-isopropylmalate dehydratase activity
LEPBI_RS06035	COG0840	transmembrane signaling receptor activity
LEPBI_RS06060	COG1595	DNA-templated transcription, initiation
LEPBI_RS06150	COG0523	cobalamin synthesis protein
LEPBI_RS06160	COG3290	protein histidine kinase activity
LEPBI_RS06160	COG0840	transmembrane signaling receptor activity
LEPBI_RS06165	COG1960	acyl-CoA dehydrogenase activity
LEPBI_RS06190	COG1121	(ABC) transporter
LEPBI_RS06210	COG2200	EAL domain
LEPBI_RS06235	COG1385	rRNA (uridine-N3-)-methyltransferase activity
LEPBI_RS06260	COG2373	Large extracellular alpha-helical protein
LEPBI_RS06305	COG4191	Histidine kinase
LEPBI_RS06340	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
LEPBI_RS06345	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LEPBI_RS06355	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LEPBI_RS06365	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
LEPBI_RS06395	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LEPBI_RS06410	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
LEPBI_RS06410	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
LEPBI_RS06430	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
LEPBI_RS06455	COG0793	Belongs to the peptidase S41A family
LEPBI_RS06465	COG1183	phosphatidylcholine synthase activity
LEPBI_RS06475	COG1234	tRNA 3'-trailer cleavage
LEPBI_RS06520	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LEPBI_RS06520	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
LEPBI_RS06540	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
LEPBI_RS06545	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
LEPBI_RS06555	COG2203	Gaf domain
LEPBI_RS06555	COG2199	diguanylate cyclase activity
LEPBI_RS06660	COG0488	(ABC) transporter
LEPBI_RS06665	COG0450	alkyl hydroperoxide reductase
LEPBI_RS06705	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
LEPBI_RS06715	COG0437	4 iron, 4 sulfur cluster binding
LEPBI_RS06750	COG1846	Transcriptional regulator
LEPBI_RS06775	COG1024	Enoyl-CoA hydratase
LEPBI_RS06785	COG2259	Doxx family
LEPBI_RS06790	COG0739	heme binding
LEPBI_RS06870	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LEPBI_RS06875	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LEPBI_RS06875	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LEPBI_RS06880	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LEPBI_RS06880	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LEPBI_RS06885	COG0307	riboflavin synthase, alpha
LEPBI_RS06895	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LEPBI_RS06895	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LEPBI_RS06910	COG0436	Aminotransferase
LEPBI_RS06915	COG0714	Associated with various cellular activities
LEPBI_RS06960	COG0174	glutamine synthetase
LEPBI_RS06975	COG0745	RESPONSE REGULATOR receiver
LEPBI_RS06985	COG1830	Aldolase
LEPBI_RS06990	COG1640	4-alpha-glucanotransferase
LEPBI_RS07015	COG1388	LysM domain
LEPBI_RS07015	COG4942	peptidase
LEPBI_RS07055	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LEPBI_RS07145	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LEPBI_RS07150	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LEPBI_RS07185	COG1187	pseudouridine synthase activity
LEPBI_RS07220	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
LEPBI_RS07225	COG1516	flagellar protein fliS
LEPBI_RS07235	COG0484	heat shock protein binding
LEPBI_RS07250	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
LEPBI_RS07265	COG0586	Pfam SNARE associated Golgi protein
LEPBI_RS07275	COG0625	glutathione transferase activity
LEPBI_RS07290	COG5002	protein histidine kinase activity
LEPBI_RS07300	COG0784	Response regulator, receiver
LEPBI_RS07300	COG2205	protein histidine kinase activity
LEPBI_RS07310	COG0840	transmembrane signaling receptor activity
LEPBI_RS07335	COG3040	lipid binding
LEPBI_RS07345	COG0537	adenosine 5'-monophosphoramidase activity
LEPBI_RS07355	COG0577	efflux transmembrane transporter activity
LEPBI_RS07355	COG1136	(ABC) transporter
LEPBI_RS07385	COG0791	NLP P60 protein
LEPBI_RS07405	COG0501	Belongs to the peptidase M48B family
LEPBI_RS07410	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
LEPBI_RS07485	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
LEPBI_RS07485	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
LEPBI_RS07500	COG0195	Participates in both transcription termination and antitermination
LEPBI_RS07530	COG0612	Peptidase, M16
LEPBI_RS07565	COG1295	ribonuclease BN
LEPBI_RS07600	COG0604	alcohol dehydrogenase
LEPBI_RS07605	COG1028	Short-chain dehydrogenase reductase Sdr
LEPBI_RS07615	COG1028	Short-chain dehydrogenase reductase Sdr
LEPBI_RS07630	COG3437	response regulator, receiver
LEPBI_RS07665	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
LEPBI_RS07675	COG0508	dehydrogenase complex catalyzes the overall conversion of
LEPBI_RS07680	COG0508	dehydrogenase complex catalyzes the overall conversion of
LEPBI_RS07680	COG0022	dehydrogenase e1 component
LEPBI_RS07685	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
LEPBI_RS07720	COG0358	DNA primase activity
LEPBI_RS07735	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
LEPBI_RS07745	COG0726	polysaccharide deacetylase
LEPBI_RS07770	COG2208	phosphoserine phosphatase activity
LEPBI_RS07770	COG2770	Histidine kinase
LEPBI_RS07780	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LEPBI_RS07800	COG0835	chemotaxis
LEPBI_RS07810	COG0643	Histidine kinase
LEPBI_RS07810	COG2198	Histidine kinase
LEPBI_RS07820	COG0745	RESPONSE REGULATOR receiver
LEPBI_RS07825	COG2201	protein-glutamate methylesterase activity
LEPBI_RS07830	COG2202	Pas domain
LEPBI_RS07830	COG2205	protein histidine kinase activity
LEPBI_RS07845	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
LEPBI_RS07885	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LEPBI_RS07905	COG0330	HflC and HflK could
LEPBI_RS07910	COG0330	HflC and HflK could
LEPBI_RS07930	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LEPBI_RS07945	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
LEPBI_RS07995	COG0463	Glycosyl transferase, family 2
LEPBI_RS08045	COG1752	Esterase of the alpha-beta hydrolase superfamily
LEPBI_RS08050	COG0497	DNA recombination
LEPBI_RS08055	COG0811	peptide transport
LEPBI_RS08060	COG0848	biopolymer transport protein
LEPBI_RS08065	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LEPBI_RS08080	COG1218	3'(2'),5'-bisphosphate nucleotidase
LEPBI_RS08100	COG1022	Amp-dependent synthetase and ligase
LEPBI_RS08110	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
LEPBI_RS08115	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
LEPBI_RS08115	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
LEPBI_RS08120	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
LEPBI_RS08120	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
LEPBI_RS08165	COG5000	phosphorelay sensor kinase activity
LEPBI_RS08170	COG2204	response regulator
LEPBI_RS08180	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
LEPBI_RS08190	COG0515	serine threonine protein kinase
LEPBI_RS08190	COG2815	serine threonine protein kinase
LEPBI_RS08225	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
LEPBI_RS08240	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
LEPBI_RS08245	COG0792	nuclease activity
LEPBI_RS08280	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LEPBI_RS08285	COG1459	type II secretion system
LEPBI_RS08375	COG0659	secondary active sulfate transmembrane transporter activity
LEPBI_RS08390	COG1053	succinate dehydrogenase
LEPBI_RS08395	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
LEPBI_RS08405	COG0463	Glycosyl transferase, family 2
LEPBI_RS08405	COG1216	Glycosyl transferase, family 2
LEPBI_RS08440	COG0312	modulator of DNA gyrase
LEPBI_RS08445	COG0312	modulator of DNA gyrase
LEPBI_RS08485	COG0733	neurotransmitter:sodium symporter activity
LEPBI_RS08490	COG1199	ATP-dependent helicase activity
LEPBI_RS08515	COG3458	cephalosporin-C deacetylase activity
LEPBI_RS08570	COG5002	protein histidine kinase activity
LEPBI_RS08575	COG0210	DNA helicase
LEPBI_RS08590	COG5001	Diguanylate cyclase
LEPBI_RS08630	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LEPBI_RS08650	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
LEPBI_RS08660	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LEPBI_RS08665	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
LEPBI_RS08715	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
LEPBI_RS08730	COG0004	ammonium transporteR
LEPBI_RS08735	COG2208	phosphoserine phosphatase activity
LEPBI_RS08755	COG1217	gtp-binding protein TYPA
LEPBI_RS08790	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
LEPBI_RS08795	COG1713	HD superfamily hydrolase involved in NAD metabolism
LEPBI_RS08805	COG0799	negative regulation of ribosome biogenesis
LEPBI_RS08810	COG1331	Highly conserved protein containing a thioredoxin domain
LEPBI_RS08820	COG1473	amidohydrolase
LEPBI_RS08835	COG0006	proline dipeptidase activity
LEPBI_RS08845	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LEPBI_RS08855	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
LEPBI_RS08855	COG0116	Belongs to the methyltransferase superfamily
LEPBI_RS08860	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
LEPBI_RS08875	COG1181	Belongs to the D-alanine--D-alanine ligase family
LEPBI_RS08895	COG3706	GGDEF domain
LEPBI_RS08900	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
LEPBI_RS08905	COG2181	nitrate reductase activity
LEPBI_RS08905	COG0247	lactate metabolic process
LEPBI_RS08925	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
LEPBI_RS08975	COG0484	heat shock protein binding
LEPBI_RS09010	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
LEPBI_RS09035	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
LEPBI_RS09040	COG0708	Exodeoxyribonuclease III
LEPBI_RS09055	COG2239	Acts as a magnesium transporter
LEPBI_RS09065	COG1360	Flagellar Motor Protein
LEPBI_RS09085	COG0616	signal peptide processing
LEPBI_RS09090	COG0009	L-threonylcarbamoyladenylate synthase
LEPBI_RS09095	COG3858	chitin binding
LEPBI_RS09095	COG1388	LysM domain
LEPBI_RS09105	COG0584	glycerophosphoryl diester phosphodiesterase
LEPBI_RS09125	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LEPBI_RS09150	COG0542	response to heat
LEPBI_RS09165	COG0840	transmembrane signaling receptor activity
LEPBI_RS09180	COG0628	permease
LEPBI_RS09195	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LEPBI_RS09210	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LEPBI_RS09215	COG1127	ABC transporter
LEPBI_RS09230	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LEPBI_RS09240	COG2096	Adenosyltransferase
LEPBI_RS09250	COG2885	chlorophyll binding
LEPBI_RS09250	COG3047	cAMP biosynthetic process
LEPBI_RS09255	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
LEPBI_RS09260	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LEPBI_RS09260	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LEPBI_RS09265	COG1192	Involved in chromosome partitioning
LEPBI_RS09280	COG1022	Amp-dependent synthetase and ligase
LEPBI_RS09285	COG0308	aminopeptidase N
LEPBI_RS09290	COG0724	RNA recognition motif
LEPBI_RS09295	COG4943	cyclic-guanylate-specific phosphodiesterase activity
LEPBI_RS09300	COG4772	TonB-dependent receptor
LEPBI_RS09375	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LEPBI_RS09390	COG2356	endonuclease I
LEPBI_RS09395	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LEPBI_RS09405	COG1131	(ABC) transporter
LEPBI_RS09410	COG0842	Transport permease protein
LEPBI_RS09415	COG0271	Belongs to the BolA IbaG family
LEPBI_RS09420	COG0625	glutathione transferase activity
LEPBI_RS09430	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
LEPBI_RS09450	COG0405	Gamma-glutamyltransferase
LEPBI_RS09465	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
LEPBI_RS09470	COG2146	nitrite reductase [NAD(P)H] activity
LEPBI_RS09475	COG0719	Fe-S assembly protein
LEPBI_RS09480	COG0396	ATPase activity
LEPBI_RS09485	COG2202	Pas domain
LEPBI_RS09485	COG2199	diguanylate cyclase activity
LEPBI_RS09485	COG2200	EAL domain
LEPBI_RS09490	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
LEPBI_RS09495	COG0047	phosphoribosylformylglycinamidine synthase activity
LEPBI_RS09500	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LEPBI_RS09525	COG4555	ABC transporter
LEPBI_RS09565	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
LEPBI_RS09570	COG3852	Histidine kinase
LEPBI_RS09610	COG0201	protein transport
LEPBI_RS09720	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
LEPBI_RS09765	COG0250	Participates in transcription elongation, termination and antitermination
LEPBI_RS09770	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
LEPBI_RS09785	COG1639	'signal transduction protein
LEPBI_RS09790	COG1028	Short-chain dehydrogenase reductase Sdr
LEPBI_RS09795	COG0640	Transcriptional regulator
LEPBI_RS09805	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
LEPBI_RS09835	COG0463	Glycosyl transferase, family 2
LEPBI_RS09865	COG1215	transferase activity, transferring glycosyl groups
LEPBI_RS09875	COG1216	Glycosyl transferase, family 2
LEPBI_RS09905	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LEPBI_RS09945	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LEPBI_RS09995	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
LEPBI_RS10005	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
LEPBI_RS10010	COG2089	acid synthase
LEPBI_RS10015	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
LEPBI_RS10035	COG3980	spore coat polysaccharide biosynthesis protein
LEPBI_RS10040	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
LEPBI_RS10055	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
LEPBI_RS10060	COG1086	Polysaccharide biosynthesis protein
LEPBI_RS10065	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LEPBI_RS10070	COG1088	dTDP-glucose 4,6-dehydratase activity
LEPBI_RS10075	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
LEPBI_RS10105	COG1902	pentaerythritol trinitrate reductase activity
LEPBI_RS10105	COG0446	pyridine nucleotide-disulphide oxidoreductase
LEPBI_RS10115	COG2205	protein histidine kinase activity
LEPBI_RS10120	COG4221	oxidoreductase activity
LEPBI_RS10150	COG0840	transmembrane signaling receptor activity
LEPBI_RS10210	COG0625	glutathione transferase activity
LEPBI_RS10260	COG0840	transmembrane signaling receptor activity
LEPBI_RS10270	COG5002	protein histidine kinase activity
LEPBI_RS10275	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
LEPBI_RS10300	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LEPBI_RS10300	COG4191	Histidine kinase
LEPBI_RS10305	COG2207	Transcriptional regulator
LEPBI_RS10305	COG4753	response regulator
LEPBI_RS10345	COG1702	phosphate starvation-inducible protein PhoH
LEPBI_RS10355	COG0305	Participates in initiation and elongation during chromosome replication
LEPBI_RS10370	COG0629	single-stranded DNA binding
LEPBI_RS10385	COG2843	Capsule synthesis protein
LEPBI_RS10420	COG1595	DNA-templated transcription, initiation
LEPBI_RS10430	COG0012	GTP binding
LEPBI_RS10440	COG0564	pseudouridine synthase activity
LEPBI_RS10455	COG3876	Protein conserved in bacteria
LEPBI_RS10465	COG2207	Transcriptional regulator
LEPBI_RS10465	COG4753	response regulator
LEPBI_RS10480	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LEPBI_RS10490	COG2249	NAD(P)H dehydrogenase (quinone) activity
LEPBI_RS10545	COG0860	N-Acetylmuramoyl-L-alanine amidase
LEPBI_RS10585	COG1543	Belongs to the glycosyl hydrolase 57 family
LEPBI_RS10775	COG2226	methyltransferase
LEPBI_RS10840	COG4680	protein conserved in bacteria
LEPBI_RS10985	COG5566	PFAM Mor transcription activator
LEPBI_RS11065	COG3654	unkown
LEPBI_RS11095	COG1487	ribonuclease activity
LEPBI_RS11165	COG1742	UPF0060 membrane protein
LEPBI_RS11195	COG0625	glutathione transferase activity
LEPBI_RS11200	COG2076	Multidrug Resistance protein
LEPBI_RS11215	COG1187	pseudouridine synthase activity
LEPBI_RS11225	COG0840	transmembrane signaling receptor activity
LEPBI_RS11260	COG0463	Glycosyl transferase, family 2
LEPBI_RS11270	COG0366	Alpha amylase catalytic
LEPBI_RS11275	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
LEPBI_RS11285	COG0840	transmembrane signaling receptor activity
LEPBI_RS11305	COG0728	peptidoglycan biosynthetic process
LEPBI_RS11350	COG3118	belongs to the thioredoxin family
LEPBI_RS11360	COG1960	acyl-CoA dehydrogenase activity
LEPBI_RS11390	COG2814	Major facilitator Superfamily
LEPBI_RS11415	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LEPBI_RS11440	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LEPBI_RS11445	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LEPBI_RS11505	COG1366	Belongs to the anti-sigma-factor antagonist family
LEPBI_RS11515	COG0735	belongs to the Fur family
LEPBI_RS11550	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LEPBI_RS11560	COG2198	Histidine kinase
LEPBI_RS11560	COG5002	protein histidine kinase activity
LEPBI_RS11560	COG0784	Response regulator, receiver
LEPBI_RS11565	COG0433	COG0433 Predicted ATPase
LEPBI_RS11590	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
LEPBI_RS11600	COG0489	protein tyrosine kinase activity
LEPBI_RS11620	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
LEPBI_RS11660	COG0440	acetolactate synthase activity
LEPBI_RS11665	COG0028	Belongs to the TPP enzyme family
LEPBI_RS11695	COG0698	ribose 5-phosphate isomerase
LEPBI_RS11725	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
LEPBI_RS11745	COG0210	DNA helicase
LEPBI_RS11780	COG3876	Protein conserved in bacteria
LEPBI_RS11790	COG1605	Chorismate mutase
LEPBI_RS11790	COG0077	Prephenate dehydratase
LEPBI_RS11795	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
LEPBI_RS11805	COG2201	protein-glutamate methylesterase activity
LEPBI_RS11815	COG0643	Histidine kinase
LEPBI_RS11815	COG2198	Histidine kinase
LEPBI_RS11820	COG0835	chemotaxis
LEPBI_RS11825	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
LEPBI_RS11830	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
LEPBI_RS11875	COG4178	(ABC) transporter
LEPBI_RS11880	COG3459	Glycosyltransferase 36 associated
LEPBI_RS11885	COG0347	Belongs to the P(II) protein family
LEPBI_RS11890	COG0004	ammonium transporteR
LEPBI_RS11920	COG2385	sporulation resulting in formation of a cellular spore
LEPBI_RS11940	COG0649	NAD binding
LEPBI_RS11945	COG0651	ATP synthesis coupled electron transport
LEPBI_RS11960	COG1007	ATP synthesis coupled electron transport
LEPBI_RS11970	COG1136	(ABC) transporter
LEPBI_RS12000	COG1858	cytochrome C peroxidase
LEPBI_RS12025	COG0840	transmembrane signaling receptor activity
LEPBI_RS12040	COG0038	chloride channel
LEPBI_RS12050	COG5002	protein histidine kinase activity
LEPBI_RS12050	COG5001	Diguanylate cyclase
LEPBI_RS12050	COG3447	MASE1 domain protein
LEPBI_RS12080	COG0656	L-ascorbic acid biosynthetic process
LEPBI_RS12085	COG0542	response to heat
LEPBI_RS12095	COG2205	protein histidine kinase activity
LEPBI_RS12095	COG0784	Response regulator, receiver
LEPBI_RS12120	COG2379	hydroxypyruvate reductase
LEPBI_RS12125	COG0492	ferredoxin-NADP+ reductase activity
LEPBI_RS12130	COG2198	Histidine kinase
LEPBI_RS12130	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LEPBI_RS12130	COG0784	Response regulator, receiver
LEPBI_RS12130	COG2205	protein histidine kinase activity
LEPBI_RS12155	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
LEPBI_RS12170	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LEPBI_RS12185	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
LEPBI_RS12210	COG1309	transcriptional regulator
LEPBI_RS12225	COG1272	protein, Hemolysin III
LEPBI_RS12235	COG1960	acyl-CoA dehydrogenase activity
LEPBI_RS12240	COG0446	pyridine nucleotide-disulphide oxidoreductase
LEPBI_RS12240	COG1902	pentaerythritol trinitrate reductase activity
LEPBI_RS12265	COG0702	epimerase
LEPBI_RS12275	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LEPBI_RS12295	COG4302	ethanolamine ammonia-lyase activity
LEPBI_RS12305	COG3046	protein related to deoxyribodipyrimidine photolyase
LEPBI_RS12320	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
LEPBI_RS12340	COG0514	ATP-dependent DNA helicase (RecQ)
LEPBI_RS12390	COG3279	Response regulator of the LytR AlgR family
LEPBI_RS12415	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LEPBI_RS12445	COG2197	response regulator
LEPBI_RS12460	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
LEPBI_RS12500	COG0783	Belongs to the Dps family
LEPBI_RS12505	COG0596	Alpha beta hydrolase
LEPBI_RS12525	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LEPBI_RS12530	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
LEPBI_RS12535	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
LEPBI_RS12540	COG1684	flagellar biosynthetic protein fliR
LEPBI_RS12545	COG1987	bacterial-type flagellum assembly
LEPBI_RS12550	COG1338	Plays a role in the flagellum-specific transport system
LEPBI_RS12560	COG1776	CheC inhibitor of MCP methylation
LEPBI_RS12560	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
LEPBI_RS12570	COG0688	phosphatidylethanolamine metabolic process
LEPBI_RS12655	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LEPBI_RS12670	COG0542	response to heat
LEPBI_RS12675	COG3869	Catalyzes the specific phosphorylation of arginine residues in
LEPBI_RS12680	COG1136	(ABC) transporter
LEPBI_RS12685	COG4591	ABC-type transport system involved in lipoprotein release permease component
LEPBI_RS12720	COG0571	ribonuclease III activity
LEPBI_RS12745	COG1028	Short-chain dehydrogenase reductase Sdr
LEPBI_RS12765	COG2183	response to ionizing radiation
LEPBI_RS12765	COG0539	negative regulation of cytoplasmic translation
LEPBI_RS12790	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LEPBI_RS12840	COG0750	zinc metalloprotease
LEPBI_RS12850	COG0575	Belongs to the CDS family
LEPBI_RS12885	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
LEPBI_RS12890	COG3387	PFAM Glycoside hydrolase 15-related
LEPBI_RS12895	COG5002	protein histidine kinase activity
LEPBI_RS12910	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
LEPBI_RS12925	COG3706	GGDEF domain
LEPBI_RS12950	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LEPBI_RS12955	COG1639	'signal transduction protein
LEPBI_RS12960	COG2860	membrane
LEPBI_RS12985	COG0662	Cupin 2, conserved barrel domain protein
LEPBI_RS12985	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
LEPBI_RS12995	COG0784	Response regulator, receiver
LEPBI_RS12995	COG5002	protein histidine kinase activity
LEPBI_RS13020	COG1028	Short-chain dehydrogenase reductase Sdr
LEPBI_RS13035	COG1177	transmembrane transport
LEPBI_RS13040	COG1176	ABC-type spermidine putrescine transport system, permease component I
LEPBI_RS13045	COG3842	ATPase activity
LEPBI_RS13050	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
LEPBI_RS13060	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
LEPBI_RS13065	COG1012	belongs to the aldehyde dehydrogenase family
LEPBI_RS13105	COG0488	(ABC) transporter
LEPBI_RS13125	COG1040	competence protein
LEPBI_RS13155	COG4956	integral membrane protein (PIN domain superfamily)
LEPBI_RS13190	COG1845	cytochrome c oxidase, subunit III
LEPBI_RS13205	COG1999	signal sequence binding
LEPBI_RS13210	COG1612	heme a metabolic process
LEPBI_RS13225	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
LEPBI_RS13240	COG1366	Belongs to the anti-sigma-factor antagonist family
LEPBI_RS13255	COG1090	epimerase
LEPBI_RS13335	COG0024	Methionine aminopeptidase
LEPBI_RS13355	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
LEPBI_RS13420	COG0842	Transport permease protein
LEPBI_RS13425	COG1131	(ABC) transporter
LEPBI_RS13430	COG0488	(ABC) transporter
LEPBI_RS13445	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
LEPBI_RS13460	COG2217	Heavy metal translocating P-type atpase
LEPBI_RS13475	COG0789	Transcriptional regulator
LEPBI_RS13510	COG0745	RESPONSE REGULATOR receiver
LEPBI_RS13525	COG0300	oxidoreductase activity
LEPBI_RS13550	COG3250	beta-galactosidase activity
LEPBI_RS13590	COG0243	molybdopterin cofactor binding
LEPBI_RS13600	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LEPBI_RS13610	COG1648	precorrin-2 dehydrogenase activity
LEPBI_RS13610	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LEPBI_RS13615	COG0521	Mo-molybdopterin cofactor biosynthetic process
LEPBI_RS13615	COG0315	cyclic pyranopterin monophosphate synthase activity
LEPBI_RS13620	COG0303	'Molybdopterin
LEPBI_RS13630	COG0243	molybdopterin cofactor binding
LEPBI_RS13635	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
LEPBI_RS13640	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
LEPBI_RS13650	COG0314	molybdopterin synthase activity
LEPBI_RS13655	COG0746	molybdenum cofactor guanylyltransferase activity
LEPBI_RS13665	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LEPBI_RS13665	COG2205	protein histidine kinase activity
LEPBI_RS13665	COG2198	Histidine kinase
LEPBI_RS13665	COG0784	Response regulator, receiver
LEPBI_RS13690	COG1846	Transcriptional regulator
LEPBI_RS13700	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LEPBI_RS13720	COG0446	pyridine nucleotide-disulphide oxidoreductase
LEPBI_RS13725	COG2205	protein histidine kinase activity
LEPBI_RS13755	COG2207	Transcriptional regulator
LEPBI_RS13755	COG3708	Transcriptional regulator
LEPBI_RS13765	COG0724	RNA recognition motif
LEPBI_RS13780	COG1309	transcriptional regulator
LEPBI_RS13785	COG2197	response regulator
LEPBI_RS13870	COG0513	Belongs to the DEAD box helicase family
LEPBI_RS13955	COG0735	belongs to the Fur family
LEPBI_RS13960	COG0617	tRNA 3'-terminal CCA addition
LEPBI_RS13980	COG0840	transmembrane signaling receptor activity
LEPBI_RS13985	COG1858	cytochrome C peroxidase
LEPBI_RS14005	COG0505	Belongs to the CarA family
LEPBI_RS14030	COG1639	'signal transduction protein
LEPBI_RS14045	COG4399	Belongs to the UPF0754 family
LEPBI_RS14050	COG1090	epimerase
LEPBI_RS14065	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LEPBI_RS14075	COG0798	PFAM Bile acid sodium symporter
LEPBI_RS14080	COG1902	pentaerythritol trinitrate reductase activity
LEPBI_RS14080	COG0446	pyridine nucleotide-disulphide oxidoreductase
LEPBI_RS14095	COG0557	exoribonuclease II activity
LEPBI_RS14115	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LEPBI_RS14115	COG0596	Alpha beta hydrolase
LEPBI_RS14115	COG2226	methyltransferase
LEPBI_RS14135	COG0640	Transcriptional regulator
LEPBI_RS14210	COG1162	GTPase activity
LEPBI_RS14245	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LEPBI_RS14305	COG5566	PFAM Mor transcription activator
LEPBI_RS14310	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LEPBI_RS14380	COG0739	heme binding
LEPBI_RS14385	COG1022	Amp-dependent synthetase and ligase
LEPBI_RS14400	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
LEPBI_RS14445	COG1317	bacterial-type flagellum organization
LEPBI_RS14450	COG3850	Histidine kinase
LEPBI_RS14450	COG5002	protein histidine kinase activity
LEPBI_RS14485	COG2010	Cytochrome c
LEPBI_RS14535	COG3958	Transketolase
LEPBI_RS14580	COG5001	Diguanylate cyclase
LEPBI_RS14580	COG3447	MASE1 domain protein
LEPBI_RS14580	COG5002	protein histidine kinase activity
LEPBI_RS14585	COG3279	Response regulator of the LytR AlgR family
LEPBI_RS14590	COG0069	glutamate synthase activity
LEPBI_RS14600	COG0531	amino acid
LEPBI_RS14700	COG1309	transcriptional regulator
LEPBI_RS14710	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LEPBI_RS14715	COG2373	Large extracellular alpha-helical protein
LEPBI_RS14735	COG0450	alkyl hydroperoxide reductase
LEPBI_RS14750	COG3279	Response regulator of the LytR AlgR family
LEPBI_RS14780	COG0811	peptide transport
LEPBI_RS14800	COG1999	signal sequence binding
LEPBI_RS14825	COG1136	(ABC) transporter
LEPBI_RS14825	COG0577	efflux transmembrane transporter activity
LEPBI_RS14885	COG2226	methyltransferase
LEPBI_RS14920	COG1309	transcriptional regulator
LEPBI_RS14945	COG1063	alcohol dehydrogenase
LEPBI_RS14955	COG1611	Belongs to the LOG family
LEPBI_RS15060	COG0772	Belongs to the SEDS family
LEPBI_RS15070	COG0196	riboflavin kinase activity
LEPBI_RS15090	COG0484	heat shock protein binding
LEPBI_RS15095	COG1482	cell wall glycoprotein biosynthetic process
LEPBI_RS15100	COG1741	Belongs to the pirin family
LEPBI_RS15115	COG2271	Major facilitator Superfamily
LEPBI_RS15130	COG2826	transposase and inactivated derivatives, IS30 family
LEPBI_RS15150	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LEPBI_RS15155	COG1696	Membrane protein involved in D-alanine export
LEPBI_RS15185	COG0412	Dienelactone hydrolase
LEPBI_RS15190	COG1960	acyl-CoA dehydrogenase activity
LEPBI_RS15210	COG3920	Histidine kinase
LEPBI_RS15250	COG0604	alcohol dehydrogenase
LEPBI_RS15260	COG0604	alcohol dehydrogenase
LEPBI_RS15275	COG1858	cytochrome C peroxidase
LEPBI_RS15310	COG0724	RNA recognition motif
LEPBI_RS15350	COG1053	succinate dehydrogenase
LEPBI_RS15375	COG2217	Heavy metal translocating P-type atpase
LEPBI_RS15425	COG0564	pseudouridine synthase activity
LEPBI_RS15435	COG0861	Integral membrane protein TerC family
LEPBI_RS15445	COG5002	protein histidine kinase activity
LEPBI_RS15450	COG2197	response regulator
LEPBI_RS15460	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
LEPBI_RS15475	COG2885	chlorophyll binding
LEPBI_RS15485	COG3119	arylsulfatase activity
LEPBI_RS15485	COG3408	Glycogen debranching enzyme
LEPBI_RS15495	COG2030	dehydratase
LEPBI_RS15525	COG2720	vancomycin resistance protein
LEPBI_RS15540	COG3118	belongs to the thioredoxin family
LEPBI_RS15555	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
LEPBI_RS15650	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LEPBI_RS15650	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LEPBI_RS15650	COG1703	isobutyryl-CoA mutase activity
LEPBI_RS15655	COG0204	Acyl-transferase
LEPBI_RS15675	COG0745	RESPONSE REGULATOR receiver
LEPBI_RS15685	COG3591	Belongs to the peptidase S1B family
LEPBI_RS15700	COG1501	Belongs to the glycosyl hydrolase 31 family
LEPBI_RS15730	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
LEPBI_RS15800	COG0745	RESPONSE REGULATOR receiver
LEPBI_RS15805	COG5002	protein histidine kinase activity
LEPBI_RS15830	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LEPBI_RS15840	COG1560	Kdo2-lipid A biosynthetic process
LEPBI_RS15890	COG0840	transmembrane signaling receptor activity
LEPBI_RS15905	COG1024	Enoyl-CoA hydratase
LEPBI_RS15920	COG0346	lactoylglutathione lyase activity
LEPBI_RS15935	COG2814	Major facilitator Superfamily
LEPBI_RS15945	COG0436	Aminotransferase
LEPBI_RS15965	COG0501	Belongs to the peptidase M48B family
LEPBI_RS15995	COG0483	inositol monophosphate 1-phosphatase activity
LEPBI_RS16005	COG3853	Toxic anion resistance protein (TelA)
LEPBI_RS16030	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
LEPBI_RS16030	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
LEPBI_RS16035	COG4221	oxidoreductase activity
LEPBI_RS16040	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
LEPBI_RS16060	COG2205	protein histidine kinase activity
LEPBI_RS16060	COG0784	Response regulator, receiver
LEPBI_RS16070	COG4935	Belongs to the peptidase S8 family
LEPBI_RS16070	COG1404	Belongs to the peptidase S8 family
LEPBI_RS16130	COG1063	alcohol dehydrogenase
LEPBI_RS16145	COG2070	2-Nitropropane dioxygenase
LEPBI_RS16150	COG4232	protein-disulfide reductase activity
LEPBI_RS16185	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LEPBI_RS16250	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
LEPBI_RS16255	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
LEPBI_RS16295	COG0494	nUDIX hydrolase
LEPBI_RS16305	COG0667	Aldo Keto reductase
LEPBI_RS16335	COG0739	heme binding
LEPBI_RS16355	COG2363	Small membrane protein
LEPBI_RS16365	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
LEPBI_RS16380	COG0534	Mate efflux family protein
LEPBI_RS16395	COG1902	pentaerythritol trinitrate reductase activity
LEPBI_RS16425	COG0129	dihydroxy-acid dehydratase activity
LEPBI_RS16455	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LEPBI_RS16495	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
LEPBI_RS16500	COG0812	UDP-N-acetylmuramate dehydrogenase activity
LEPBI_RS16505	COG1393	Belongs to the ArsC family
LEPBI_RS16515	COG1305	Transglutaminase-like
LEPBI_RS16535	COG2308	Evidence 4 Homologs of previously reported genes of
LEPBI_RS16545	COG1678	Uncharacterized ACR, COG1678
LEPBI_RS16550	COG0673	inositol 2-dehydrogenase activity
LEPBI_RS16575	COG5002	protein histidine kinase activity
LEPBI_RS16575	COG5001	Diguanylate cyclase
LEPBI_RS16575	COG3447	MASE1 domain protein
LEPBI_RS16590	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
LEPBI_RS16595	COG0366	Alpha amylase catalytic
LEPBI_RS16660	COG1487	ribonuclease activity
LEPBI_RS16665	COG4456	Virulence-associated protein
LEPBI_RS16670	COG0183	Belongs to the thiolase family
LEPBI_RS16685	COG1034	ATP synthesis coupled electron transport
LEPBI_RS16690	COG2201	protein-glutamate methylesterase activity
LEPBI_RS16710	COG0517	IMP dehydrogenase activity
LEPBI_RS16710	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
LEPBI_RS16775	COG1309	transcriptional regulator
LEPBI_RS16795	COG1196	nuclear chromosome segregation
LEPBI_RS16795	COG0741	lytic transglycosylase activity
LEPBI_RS16795	COG0739	heme binding
LEPBI_RS16815	COG4771	TonB-dependent receptor
LEPBI_RS16835	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
LEPBI_RS16855	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
LEPBI_RS16935	COG0596	Alpha beta hydrolase
LEPBI_RS16970	COG0590	tRNA wobble adenosine to inosine editing
LEPBI_RS16980	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
LEPBI_RS17015	COG0084	hydrolase, TatD family'
LEPBI_RS17020	COG0739	heme binding
LEPBI_RS17035	COG1132	(ABC) transporter
LEPBI_RS17040	COG1475	DNA binding
LEPBI_RS17045	COG1192	Involved in chromosome partitioning
LEPBI_RS17065	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LEPBI_RS17070	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
LEPBI_RS17300	COG2826	transposase and inactivated derivatives, IS30 family
LEPBI_RS17775	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
LEPBI_RS18470	COG0187	DNA topoisomerase II activity
LEPBI_RS18750	COG1696	Membrane protein involved in D-alanine export
LEPBI_RS18775	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)