locus-tag	class	description
C4Q31_RS00010	COG0592	DNA-directed DNA polymerase activity
C4Q31_RS00025	COG0187	DNA topoisomerase II activity
C4Q31_RS00090	COG0009	L-threonylcarbamoyladenylate synthase
C4Q31_RS00135	COG0483	inositol monophosphate 1-phosphatase activity
C4Q31_RS00155	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
C4Q31_RS00160	COG0802	atpase or kinase
C4Q31_RS00170	COG0557	exoribonuclease II activity
C4Q31_RS00190	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
C4Q31_RS00190	COG0517	IMP dehydrogenase activity
C4Q31_RS00205	COG0840	transmembrane signaling receptor activity
C4Q31_RS00205	COG0840	transmembrane signaling receptor activity
C4Q31_RS00215	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C4Q31_RS00220	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
C4Q31_RS00270	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C4Q31_RS00280	COG1045	serine acetyltransferase
C4Q31_RS00295	COG0534	Mate efflux family protein
C4Q31_RS00315	COG0840	transmembrane signaling receptor activity
C4Q31_RS00330	COG1024	Enoyl-CoA hydratase
C4Q31_RS00365	COG2226	methyltransferase
C4Q31_RS00525	COG0705	Rhomboid family
C4Q31_RS00570	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C4Q31_RS00595	COG1022	Amp-dependent synthetase and ligase
C4Q31_RS00605	COG0352	thiamine-phosphate diphosphorylase activity
C4Q31_RS00605	COG0351	phosphomethylpyrimidine kinase
C4Q31_RS00620	COG3852	Histidine kinase
C4Q31_RS00625	COG1162	GTPase activity
C4Q31_RS00695	COG1132	(ABC) transporter
C4Q31_RS00700	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
C4Q31_RS00725	COG1034	ATP synthesis coupled electron transport
C4Q31_RS00790	COG0594	ribonuclease P activity
C4Q31_RS00805	COG1847	R3H domain protein
C4Q31_RS00870	COG0564	pseudouridine synthase activity
C4Q31_RS00900	COG0483	inositol monophosphate 1-phosphatase activity
C4Q31_RS00930	COG2949	membrane
C4Q31_RS00955	COG4942	peptidase
C4Q31_RS01010	COG5002	protein histidine kinase activity
C4Q31_RS01015	COG0745	RESPONSE REGULATOR receiver
C4Q31_RS01030	COG1595	DNA-templated transcription, initiation
C4Q31_RS01045	COG0494	nUDIX hydrolase
C4Q31_RS01050	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
C4Q31_RS01055	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
C4Q31_RS01110	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C4Q31_RS01140	COG0538	isocitrate dehydrogenase activity
C4Q31_RS01150	COG0745	RESPONSE REGULATOR receiver
C4Q31_RS01160	COG3956	TIGRFAM MazG family protein
C4Q31_RS01200	COG0300	oxidoreductase activity
C4Q31_RS01210	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C4Q31_RS01230	COG2271	Major facilitator Superfamily
C4Q31_RS01240	COG1560	Kdo2-lipid A biosynthetic process
C4Q31_RS01250	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C4Q31_RS01305	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C4Q31_RS01310	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C4Q31_RS01320	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C4Q31_RS01355	COG2030	dehydratase
C4Q31_RS01365	COG3119	arylsulfatase activity
C4Q31_RS01380	COG5002	protein histidine kinase activity
C4Q31_RS01405	COG1309	transcriptional regulator
C4Q31_RS01420	COG1960	acyl-CoA dehydrogenase activity
C4Q31_RS01455	COG1032	radical SAM domain protein
C4Q31_RS01570	COG0019	diaminopimelate decarboxylase activity
C4Q31_RS01590	COG4942	peptidase
C4Q31_RS01590	COG1388	LysM domain
C4Q31_RS01615	COG1024	Enoyl-CoA hydratase
C4Q31_RS01665	COG0514	ATP-dependent DNA helicase (RecQ)
C4Q31_RS01680	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C4Q31_RS01720	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C4Q31_RS01755	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C4Q31_RS01835	COG0758	DNA mediated transformation
C4Q31_RS01850	COG3384	dioxygenase
C4Q31_RS01865	COG1582	Flagellar protein (FlbD)
C4Q31_RS01875	COG1360	Flagellar Motor Protein
C4Q31_RS01890	COG1366	Belongs to the anti-sigma-factor antagonist family
C4Q31_RS01900	COG2010	Cytochrome c
C4Q31_RS01940	COG1484	DNA-dependent DNA replication
C4Q31_RS01955	COG1605	Chorismate mutase
C4Q31_RS01955	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
C4Q31_RS01975	COG2197	response regulator
C4Q31_RS02020	COG1366	Belongs to the anti-sigma-factor antagonist family
C4Q31_RS02025	COG1215	transferase activity, transferring glycosyl groups
C4Q31_RS02055	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C4Q31_RS02065	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C4Q31_RS02070	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C4Q31_RS02080	COG0004	ammonium transporteR
C4Q31_RS02085	COG0347	Belongs to the P(II) protein family
C4Q31_RS02110	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C4Q31_RS02125	COG3942	CHAP domain
C4Q31_RS02135	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C4Q31_RS02160	COG2203	Gaf domain
C4Q31_RS02160	COG2199	diguanylate cyclase activity
C4Q31_RS02195	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C4Q31_RS02205	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C4Q31_RS02210	COG1253	flavin adenine dinucleotide binding
C4Q31_RS02245	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C4Q31_RS02270	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C4Q31_RS02290	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C4Q31_RS02295	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C4Q31_RS02305	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
C4Q31_RS02315	COG0534	Mate efflux family protein
C4Q31_RS02330	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C4Q31_RS02350	COG0494	nUDIX hydrolase
C4Q31_RS02365	COG0584	glycerophosphoryl diester phosphodiesterase
C4Q31_RS02385	COG0768	penicillin binding
C4Q31_RS02415	COG0673	inositol 2-dehydrogenase activity
C4Q31_RS02420	COG1678	Uncharacterized ACR, COG1678
C4Q31_RS02485	COG2226	methyltransferase
C4Q31_RS02500	COG1028	Short-chain dehydrogenase reductase Sdr
C4Q31_RS02530	COG0704	Plays a role in the regulation of phosphate uptake
C4Q31_RS02545	COG0739	heme binding
C4Q31_RS02570	COG0783	Belongs to the Dps family
C4Q31_RS02580	COG1639	'signal transduction protein
C4Q31_RS02625	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C4Q31_RS02635	COG0772	Belongs to the SEDS family
C4Q31_RS02710	COG0724	RNA recognition motif
C4Q31_RS02720	COG5464	transposase or invertase
C4Q31_RS02740	COG1846	Transcriptional regulator
C4Q31_RS02760	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C4Q31_RS02770	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C4Q31_RS02795	COG0839	Belongs to the complex I subunit 6 family
C4Q31_RS02810	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C4Q31_RS02885	COG0596	Alpha beta hydrolase
C4Q31_RS02895	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C4Q31_RS02965	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
C4Q31_RS02970	COG0731	radical SAM domain protein
C4Q31_RS02980	COG0840	transmembrane signaling receptor activity
C4Q31_RS02985	COG0840	transmembrane signaling receptor activity
C4Q31_RS02995	COG0527	aspartate kinase activity
C4Q31_RS03000	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C4Q31_RS03025	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
C4Q31_RS03055	COG0183	Belongs to the thiolase family
C4Q31_RS03085	COG1138	Cytochrome C-type biogenesis protein
C4Q31_RS03105	COG4771	TonB-dependent receptor
C4Q31_RS03135	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C4Q31_RS03170	COG0183	Belongs to the thiolase family
C4Q31_RS03200	COG4932	domain protein
C4Q31_RS03200	COG5492	domain, Protein
C4Q31_RS03255	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C4Q31_RS03270	COG0596	Alpha beta hydrolase
C4Q31_RS03275	COG3852	Histidine kinase
C4Q31_RS03280	COG4191	Histidine kinase
C4Q31_RS03290	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C4Q31_RS03315	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
C4Q31_RS03345	COG2226	methyltransferase
C4Q31_RS03350	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4Q31_RS03355	COG3920	Histidine kinase
C4Q31_RS03355	COG2202	Pas domain
C4Q31_RS03375	COG2217	Heavy metal translocating P-type atpase
C4Q31_RS03385	COG1937	Protein conserved in bacteria
C4Q31_RS03410	COG0288	reversible hydration of carbon dioxide
C4Q31_RS03440	COG0586	Pfam SNARE associated Golgi protein
C4Q31_RS03470	COG0210	DNA helicase
C4Q31_RS03500	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
C4Q31_RS03665	COG1881	PFAM PEBP family protein
C4Q31_RS03690	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
C4Q31_RS03710	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C4Q31_RS03755	COG0612	Peptidase, M16
C4Q31_RS03760	COG0612	Peptidase, M16
C4Q31_RS03785	COG1858	cytochrome C peroxidase
C4Q31_RS03800	COG0840	transmembrane signaling receptor activity
C4Q31_RS03825	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C4Q31_RS03830	COG0250	Participates in transcription elongation, termination and antitermination
C4Q31_RS03960	COG3831	ATPase activity
C4Q31_RS03960	COG4884	unkown
C4Q31_RS03975	COG1040	competence protein
C4Q31_RS04050	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C4Q31_RS04055	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
C4Q31_RS04065	COG1132	(ABC) transporter
C4Q31_RS04070	COG1663	tetraacyldisaccharide 4'-kinase activity
C4Q31_RS04100	COG2205	protein histidine kinase activity
C4Q31_RS04100	COG0784	Response regulator, receiver
C4Q31_RS04125	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C4Q31_RS04335	COG0142	geranyltranstransferase activity
C4Q31_RS04345	COG3959	Transketolase, thiamine diphosphate binding domain
C4Q31_RS04375	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
C4Q31_RS04385	COG0386	Belongs to the glutathione peroxidase family
C4Q31_RS04405	COG0604	alcohol dehydrogenase
C4Q31_RS04425	COG0484	heat shock protein binding
C4Q31_RS04430	COG1966	Carbon starvation protein
C4Q31_RS04510	COG0193	aminoacyl-tRNA hydrolase activity
C4Q31_RS04525	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C4Q31_RS04570	COG0860	N-Acetylmuramoyl-L-alanine amidase
C4Q31_RS04575	COG0513	Belongs to the DEAD box helicase family
C4Q31_RS04590	COG0251	oxidation-reduction process
C4Q31_RS04625	COG0346	lactoylglutathione lyase activity
C4Q31_RS04660	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C4Q31_RS04660	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C4Q31_RS04665	COG0438	transferase activity, transferring glycosyl groups
C4Q31_RS04670	COG0121	glutamine amidotransferase
C4Q31_RS04705	COG1309	transcriptional regulator
C4Q31_RS04745	COG1639	'signal transduction protein
C4Q31_RS04765	COG4181	ATPase activity
C4Q31_RS04800	COG1858	cytochrome C peroxidase
C4Q31_RS04805	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C4Q31_RS04810	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C4Q31_RS04840	COG2326	polyphosphate kinase activity
C4Q31_RS04885	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
C4Q31_RS04925	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
C4Q31_RS04935	COG4943	cyclic-guanylate-specific phosphodiesterase activity
C4Q31_RS05005	COG1090	epimerase
C4Q31_RS05075	COG2166	iron-sulfur cluster assembly
C4Q31_RS05155	COG1024	Enoyl-CoA hydratase
C4Q31_RS05170	COG2192	nodulation
C4Q31_RS05250	COG0625	glutathione transferase activity
C4Q31_RS05285	COG2076	Multidrug Resistance protein
C4Q31_RS05300	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C4Q31_RS05340	COG1857	crispr-associated protein
C4Q31_RS05355	COG1203	CRISPR-associated helicase, Cas3
C4Q31_RS05375	COG0396	ATPase activity
C4Q31_RS05380	COG0719	Fe-S assembly protein
C4Q31_RS05395	COG0822	iron-sulfur transferase activity
C4Q31_RS05415	COG0385	Bile acid
C4Q31_RS05430	COG0488	(ABC) transporter
C4Q31_RS05450	COG0180	Tryptophanyl-tRNA synthetase
C4Q31_RS05470	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
C4Q31_RS05475	COG2086	electron transfer activity
C4Q31_RS05485	COG1960	acyl-CoA dehydrogenase activity
C4Q31_RS05575	COG1487	ribonuclease activity
C4Q31_RS05605	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C4Q31_RS05610	COG0463	Glycosyl transferase, family 2
C4Q31_RS05620	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C4Q31_RS05655	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C4Q31_RS05660	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
C4Q31_RS05680	COG0196	riboflavin kinase activity
C4Q31_RS05695	COG1366	Belongs to the anti-sigma-factor antagonist family
C4Q31_RS05710	COG1482	cell wall glycoprotein biosynthetic process
C4Q31_RS05780	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
C4Q31_RS05785	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C4Q31_RS05855	COG1131	(ABC) transporter
C4Q31_RS05865	COG1639	'signal transduction protein
C4Q31_RS05870	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C4Q31_RS05890	COG0842	Transport permease protein
C4Q31_RS05895	COG1131	(ABC) transporter
C4Q31_RS05900	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C4Q31_RS05905	COG1074	ATP-dependent DNA helicase activity
C4Q31_RS05910	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
C4Q31_RS05915	COG0514	ATP-dependent DNA helicase (RecQ)
C4Q31_RS05945	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C4Q31_RS05965	COG4133	protoheme IX ABC transporter activity
C4Q31_RS05990	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C4Q31_RS06075	COG0848	biopolymer transport protein
C4Q31_RS06085	COG0811	peptide transport
C4Q31_RS06140	COG0822	iron-sulfur transferase activity
C4Q31_RS06150	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
C4Q31_RS06310	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C4Q31_RS06335	COG0741	lytic transglycosylase activity
C4Q31_RS06360	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
C4Q31_RS06390	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C4Q31_RS06395	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C4Q31_RS06420	COG4585	Histidine kinase
C4Q31_RS06425	COG2197	response regulator
C4Q31_RS06455	COG3119	arylsulfatase activity
C4Q31_RS06505	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
C4Q31_RS06515	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
C4Q31_RS06605	COG0500	methyltransferase
C4Q31_RS06615	COG0243	molybdopterin cofactor binding
C4Q31_RS06685	COG3876	Protein conserved in bacteria
C4Q31_RS06700	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C4Q31_RS06715	COG0366	Alpha amylase catalytic
C4Q31_RS06735	COG0833	amino acid
C4Q31_RS06825	COG1366	Belongs to the anti-sigma-factor antagonist family
C4Q31_RS06850	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C4Q31_RS06870	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C4Q31_RS06885	COG0640	Transcriptional regulator
C4Q31_RS06935	COG1741	Belongs to the pirin family
C4Q31_RS06945	COG1217	gtp-binding protein TYPA
C4Q31_RS06950	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C4Q31_RS06950	COG2755	lipolytic protein G-D-S-L family
C4Q31_RS07020	COG1253	flavin adenine dinucleotide binding
C4Q31_RS07090	COG5001	Diguanylate cyclase
C4Q31_RS07100	COG0840	transmembrane signaling receptor activity
C4Q31_RS07135	COG1024	Enoyl-CoA hydratase
C4Q31_RS07160	COG1595	DNA-templated transcription, initiation
C4Q31_RS07170	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C4Q31_RS07185	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
C4Q31_RS07240	COG4589	Belongs to the CDS family
C4Q31_RS07250	COG0750	zinc metalloprotease
C4Q31_RS07390	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C4Q31_RS07390	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C4Q31_RS07430	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C4Q31_RS07435	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C4Q31_RS07470	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4Q31_RS07500	COG1136	(ABC) transporter
C4Q31_RS07505	COG2385	sporulation resulting in formation of a cellular spore
C4Q31_RS07585	COG1858	cytochrome C peroxidase
C4Q31_RS07610	COG1216	Glycosyl transferase, family 2
C4Q31_RS07610	COG0463	Glycosyl transferase, family 2
C4Q31_RS07670	COG4456	Virulence-associated protein
C4Q31_RS07690	COG1703	isobutyryl-CoA mutase activity
C4Q31_RS07690	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C4Q31_RS07690	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C4Q31_RS07695	COG0204	Acyl-transferase
C4Q31_RS07700	COG0671	phosphoesterase, PA-phosphatase related
C4Q31_RS07715	COG4565	transcriptional regulatory protein
C4Q31_RS07740	COG3011	Protein conserved in bacteria
C4Q31_RS07750	COG0739	heme binding
C4Q31_RS07770	COG1846	Transcriptional regulator
C4Q31_RS07780	COG1396	sequence-specific DNA binding
C4Q31_RS07810	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C4Q31_RS07890	COG0850	regulation of cytokinetic process
C4Q31_RS07930	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
C4Q31_RS07955	COG0247	lactate metabolic process
C4Q31_RS07955	COG2181	nitrate reductase activity
C4Q31_RS07965	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
C4Q31_RS08010	COG4191	Histidine kinase
C4Q31_RS08050	COG0598	Magnesium transport protein CorA
C4Q31_RS08095	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
C4Q31_RS08095	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
C4Q31_RS08120	COG0793	Belongs to the peptidase S41A family
C4Q31_RS08130	COG1183	phosphatidylcholine synthase activity
C4Q31_RS08235	COG1473	amidohydrolase
C4Q31_RS08240	COG0475	glutathione-regulated potassium exporter activity
C4Q31_RS08285	COG1295	ribonuclease BN
C4Q31_RS08290	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C4Q31_RS08400	COG1157	protein secretion by the type III secretion system
C4Q31_RS08405	COG1317	bacterial-type flagellum organization
C4Q31_RS08415	COG1766	The M ring may be actively involved in energy transduction
C4Q31_RS08460	COG2089	acid synthase
C4Q31_RS08465	COG1368	sulfuric ester hydrolase activity
C4Q31_RS08510	COG0028	Belongs to the TPP enzyme family
C4Q31_RS08515	COG0440	acetolactate synthase activity
C4Q31_RS08525	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C4Q31_RS08530	COG1472	Belongs to the glycosyl hydrolase 3 family
C4Q31_RS08535	COG2755	lipolytic protein G-D-S-L family
C4Q31_RS08575	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C4Q31_RS08580	COG0724	RNA recognition motif
C4Q31_RS08630	COG0488	(ABC) transporter
C4Q31_RS08655	COG2205	protein histidine kinase activity
C4Q31_RS08660	COG3920	Histidine kinase
C4Q31_RS08680	COG5001	Diguanylate cyclase
C4Q31_RS08680	COG4251	negative regulation of phosphorylation
C4Q31_RS08680	COG2203	Gaf domain
C4Q31_RS08680	COG3706	GGDEF domain
C4Q31_RS08685	COG2379	hydroxypyruvate reductase
C4Q31_RS08700	COG0708	Exodeoxyribonuclease III
C4Q31_RS08765	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C4Q31_RS08775	COG3458	cephalosporin-C deacetylase activity
C4Q31_RS08795	COG1960	acyl-CoA dehydrogenase activity
C4Q31_RS08830	COG3958	Transketolase
C4Q31_RS08855	COG2030	dehydratase
C4Q31_RS08865	COG0339	signal peptide processing
C4Q31_RS08875	COG0625	glutathione transferase activity
C4Q31_RS08880	COG1028	Short-chain dehydrogenase reductase Sdr
C4Q31_RS08900	COG0688	phosphatidylethanolamine metabolic process
C4Q31_RS08910	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C4Q31_RS08910	COG1776	CheC inhibitor of MCP methylation
C4Q31_RS08920	COG1338	Plays a role in the flagellum-specific transport system
C4Q31_RS08925	COG1987	bacterial-type flagellum assembly
C4Q31_RS08930	COG1684	flagellar biosynthetic protein fliR
C4Q31_RS08935	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C4Q31_RS08945	COG1419	protein localization to endoplasmic reticulum
C4Q31_RS08960	COG1191	sigma factor activity
C4Q31_RS08985	COG0194	GDP metabolic process
C4Q31_RS08995	COG1199	ATP-dependent helicase activity
C4Q31_RS09000	COG0733	neurotransmitter:sodium symporter activity
C4Q31_RS09050	COG2208	phosphoserine phosphatase activity
C4Q31_RS09050	COG2770	Histidine kinase
C4Q31_RS09070	COG4786	Flagellar basal body rod
C4Q31_RS09075	COG0735	belongs to the Fur family
C4Q31_RS09085	COG0753	catalase activity
C4Q31_RS09125	COG0724	RNA recognition motif
C4Q31_RS09145	COG0805	protein transport
C4Q31_RS09165	COG3118	belongs to the thioredoxin family
C4Q31_RS09175	COG1960	acyl-CoA dehydrogenase activity
C4Q31_RS09360	COG1028	Short-chain dehydrogenase reductase Sdr
C4Q31_RS09385	COG0617	tRNA 3'-terminal CCA addition
C4Q31_RS09415	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
C4Q31_RS09440	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C4Q31_RS09450	COG0352	thiamine-phosphate diphosphorylase activity
C4Q31_RS09480	COG0726	polysaccharide deacetylase
C4Q31_RS09480	COG1649	PFAM Uncharacterised BCR, COG1649
C4Q31_RS09535	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C4Q31_RS09560	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C4Q31_RS09565	COG0508	dehydrogenase complex catalyzes the overall conversion of
C4Q31_RS09570	COG0508	dehydrogenase complex catalyzes the overall conversion of
C4Q31_RS09570	COG0022	dehydrogenase e1 component
C4Q31_RS09575	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C4Q31_RS09580	COG0745	RESPONSE REGULATOR receiver
C4Q31_RS09585	COG2205	protein histidine kinase activity
C4Q31_RS09595	COG4452	Inner membrane protein CreD
C4Q31_RS09630	COG3876	Protein conserved in bacteria
C4Q31_RS09670	COG1127	ABC transporter
C4Q31_RS09675	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C4Q31_RS09690	COG2813	Specifically methylates the guanine in position
C4Q31_RS09690	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C4Q31_RS09705	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C4Q31_RS09720	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C4Q31_RS09725	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C4Q31_RS09725	COG1776	CheC inhibitor of MCP methylation
C4Q31_RS09735	COG0330	HflC and HflK could
C4Q31_RS09740	COG0330	HflC and HflK could
C4Q31_RS09760	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C4Q31_RS09775	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C4Q31_RS09830	COG0463	Glycosyl transferase, family 2
C4Q31_RS09845	COG0444	Belongs to the ABC transporter superfamily
C4Q31_RS09875	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
C4Q31_RS09885	COG1595	DNA-templated transcription, initiation
C4Q31_RS09900	COG0542	response to heat
C4Q31_RS09905	COG0405	Gamma-glutamyltransferase
C4Q31_RS09925	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
C4Q31_RS09930	COG0271	Belongs to the BolA IbaG family
C4Q31_RS09935	COG0271	Belongs to the BolA IbaG family
C4Q31_RS09940	COG0842	Transport permease protein
C4Q31_RS09945	COG1131	(ABC) transporter
C4Q31_RS09950	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C4Q31_RS09965	COG1234	tRNA 3'-trailer cleavage
C4Q31_RS10000	COG0616	signal peptide processing
C4Q31_RS10015	COG0436	Aminotransferase
C4Q31_RS10025	COG2267	carboxylic ester hydrolase activity
C4Q31_RS10030	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C4Q31_RS10035	COG0083	homoserine kinase activity
C4Q31_RS10055	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C4Q31_RS10055	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C4Q31_RS10065	COG0156	8-amino-7-oxononanoate synthase activity
C4Q31_RS10075	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C4Q31_RS10105	COG1496	oxidoreductase activity
C4Q31_RS10125	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C4Q31_RS10160	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C4Q31_RS10180	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C4Q31_RS10245	COG0312	modulator of DNA gyrase
C4Q31_RS10250	COG0312	modulator of DNA gyrase
C4Q31_RS10260	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C4Q31_RS10295	COG1047	Peptidyl-prolyl cis-trans
C4Q31_RS10310	COG0446	pyridine nucleotide-disulphide oxidoreductase
C4Q31_RS10310	COG1902	pentaerythritol trinitrate reductase activity
C4Q31_RS10335	COG1360	Flagellar Motor Protein
C4Q31_RS10345	COG2239	Acts as a magnesium transporter
C4Q31_RS10365	COG0784	Response regulator, receiver
C4Q31_RS10365	COG4191	Histidine kinase
C4Q31_RS10420	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C4Q31_RS10455	COG4771	TonB-dependent receptor
C4Q31_RS10470	COG1024	Enoyl-CoA hydratase
C4Q31_RS10570	COG2208	phosphoserine phosphatase activity
C4Q31_RS10575	COG1366	Belongs to the anti-sigma-factor antagonist family
C4Q31_RS10580	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C4Q31_RS10605	COG0840	transmembrane signaling receptor activity
C4Q31_RS10605	COG3290	protein histidine kinase activity
C4Q31_RS10610	COG2198	Histidine kinase
C4Q31_RS10610	COG0643	Histidine kinase
C4Q31_RS10620	COG0745	RESPONSE REGULATOR receiver
C4Q31_RS10625	COG2201	protein-glutamate methylesterase activity
C4Q31_RS10630	COG2202	Pas domain
C4Q31_RS10630	COG2205	protein histidine kinase activity
C4Q31_RS10660	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C4Q31_RS10670	COG2096	Adenosyltransferase
C4Q31_RS10675	COG3104	oligopeptide transport
C4Q31_RS10680	COG0791	NLP P60 protein
C4Q31_RS10705	COG0616	signal peptide processing
C4Q31_RS10710	COG0009	L-threonylcarbamoyladenylate synthase
C4Q31_RS10765	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C4Q31_RS10770	COG0277	FAD linked oxidase domain protein
C4Q31_RS10780	COG1024	Enoyl-CoA hydratase
C4Q31_RS10800	COG1104	cysteine desulfurase activity
C4Q31_RS10850	COG0586	Pfam SNARE associated Golgi protein
C4Q31_RS10875	COG1516	flagellar protein fliS
C4Q31_RS10880	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C4Q31_RS10910	COG1696	Membrane protein involved in D-alanine export
C4Q31_RS10915	COG1187	pseudouridine synthase activity
C4Q31_RS10960	COG4335	DNA alkylation repair
C4Q31_RS10990	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C4Q31_RS11000	COG1022	Amp-dependent synthetase and ligase
C4Q31_RS11005	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C4Q31_RS11020	COG1218	3'(2'),5'-bisphosphate nucleotidase
C4Q31_RS11035	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C4Q31_RS11040	COG0848	biopolymer transport protein
C4Q31_RS11045	COG0811	peptide transport
C4Q31_RS11050	COG0497	DNA recombination
C4Q31_RS11055	COG1639	'signal transduction protein
C4Q31_RS11060	COG1028	Short-chain dehydrogenase reductase Sdr
C4Q31_RS11065	COG0640	Transcriptional regulator
C4Q31_RS11075	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
C4Q31_RS11085	COG0012	GTP binding
C4Q31_RS11100	COG0109	protoheme IX farnesyltransferase activity
C4Q31_RS11105	COG0163	prenyltransferase activity
C4Q31_RS11115	COG0489	protein tyrosine kinase activity
C4Q31_RS11125	COG0508	dehydrogenase complex catalyzes the overall conversion of
C4Q31_RS11135	COG2133	pyrroloquinoline quinone binding
C4Q31_RS11265	COG1459	type II secretion system
C4Q31_RS11270	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C4Q31_RS11285	COG0739	heme binding
C4Q31_RS11315	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C4Q31_RS11370	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C4Q31_RS11380	COG2204	response regulator
C4Q31_RS11385	COG5000	phosphorelay sensor kinase activity
C4Q31_RS11400	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
C4Q31_RS11430	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
C4Q31_RS11430	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
C4Q31_RS11435	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
C4Q31_RS11435	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
C4Q31_RS11445	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
C4Q31_RS11460	COG0024	Methionine aminopeptidase
C4Q31_RS11570	COG0348	domain, Protein
C4Q31_RS11640	COG0492	ferredoxin-NADP+ reductase activity
C4Q31_RS11650	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C4Q31_RS11670	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C4Q31_RS11695	COG2267	carboxylic ester hydrolase activity
C4Q31_RS11705	COG0656	L-ascorbic acid biosynthetic process
C4Q31_RS11715	COG1053	succinate dehydrogenase
C4Q31_RS11730	COG2515	1-aminocyclopropane-1-carboxylate deaminase
C4Q31_RS11790	COG0784	Response regulator, receiver
C4Q31_RS11790	COG2205	protein histidine kinase activity
C4Q31_RS11790	COG5002	protein histidine kinase activity
C4Q31_RS11795	COG0784	Response regulator, receiver
C4Q31_RS11795	COG2205	protein histidine kinase activity
C4Q31_RS11795	COG2198	Histidine kinase
C4Q31_RS11805	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C4Q31_RS11890	COG1639	'signal transduction protein
C4Q31_RS11895	COG1119	ATPase activity
C4Q31_RS11900	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C4Q31_RS11920	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
C4Q31_RS11930	COG4251	negative regulation of phosphorylation
C4Q31_RS11935	COG2201	protein-glutamate methylesterase activity
C4Q31_RS11945	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C4Q31_RS11970	COG4191	Histidine kinase
C4Q31_RS11970	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4Q31_RS11975	COG2207	Transcriptional regulator
C4Q31_RS11975	COG4753	response regulator
C4Q31_RS11995	COG2361	Protein of unknown function DUF86
C4Q31_RS12035	COG1381	Involved in DNA repair and RecF pathway recombination
C4Q31_RS12045	COG1480	7TM receptor with intracellular HD hydrolase
C4Q31_RS12050	COG1702	phosphate starvation-inducible protein PhoH
C4Q31_RS12060	COG0305	Participates in initiation and elongation during chromosome replication
C4Q31_RS12075	COG0629	single-stranded DNA binding
C4Q31_RS12085	COG2843	Capsule synthesis protein
C4Q31_RS12105	COG0471	metal ion transport
C4Q31_RS12125	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
C4Q31_RS12130	COG1088	dTDP-glucose 4,6-dehydratase activity
C4Q31_RS12140	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
C4Q31_RS12145	COG1216	Glycosyl transferase, family 2
C4Q31_RS12145	COG0438	transferase activity, transferring glycosyl groups
C4Q31_RS12155	COG1215	transferase activity, transferring glycosyl groups
C4Q31_RS12175	COG1442	glycosyl transferase family 8
C4Q31_RS12205	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C4Q31_RS12270	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
C4Q31_RS12280	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C4Q31_RS12285	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C4Q31_RS12295	COG1028	Short-chain dehydrogenase reductase Sdr
C4Q31_RS12300	COG0673	inositol 2-dehydrogenase activity
C4Q31_RS12305	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
C4Q31_RS12320	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C4Q31_RS12330	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C4Q31_RS12385	COG1454	alcohol dehydrogenase
C4Q31_RS12390	COG1083	cytidylyl-transferase
C4Q31_RS12395	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C4Q31_RS12400	COG2089	acid synthase
C4Q31_RS12410	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
C4Q31_RS12415	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
C4Q31_RS12420	COG2089	acid synthase
C4Q31_RS12430	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C4Q31_RS12440	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
C4Q31_RS12450	COG1083	cytidylyl-transferase
C4Q31_RS12455	COG1132	(ABC) transporter
C4Q31_RS12460	COG0463	Glycosyl transferase, family 2
C4Q31_RS12475	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C4Q31_RS12500	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C4Q31_RS12520	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C4Q31_RS12525	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C4Q31_RS12545	COG2813	Specifically methylates the guanine in position
C4Q31_RS12550	COG0494	nUDIX hydrolase
C4Q31_RS12565	COG3958	Transketolase
C4Q31_RS12570	COG3959	Transketolase, thiamine diphosphate binding domain
C4Q31_RS12585	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
C4Q31_RS12585	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
C4Q31_RS12590	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C4Q31_RS12595	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C4Q31_RS12600	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
C4Q31_RS12610	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C4Q31_RS12660	COG1999	signal sequence binding
C4Q31_RS12720	COG1830	Aldolase
C4Q31_RS12730	COG5002	protein histidine kinase activity
C4Q31_RS12760	COG0835	chemotaxis
C4Q31_RS12805	COG0793	Belongs to the peptidase S41A family
C4Q31_RS12810	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
C4Q31_RS12845	COG5016	pyruvate
C4Q31_RS12845	COG0511	ligase activity, forming carbon-carbon bonds
C4Q31_RS12850	COG0439	Biotin carboxylase
C4Q31_RS12890	COG2070	2-Nitropropane dioxygenase
C4Q31_RS12905	COG1959	2 iron, 2 sulfur cluster binding
C4Q31_RS12940	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
C4Q31_RS12980	COG0772	Belongs to the SEDS family
C4Q31_RS12985	COG0768	penicillin binding
C4Q31_RS13025	COG4912	Dna alkylation repair
C4Q31_RS13085	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C4Q31_RS13090	COG0356	it plays a direct role in the translocation of protons across the membrane
C4Q31_RS13130	COG1309	transcriptional regulator
C4Q31_RS13145	COG0174	glutamine synthetase
C4Q31_RS13215	COG0436	Aminotransferase
C4Q31_RS13255	COG1368	sulfuric ester hydrolase activity
C4Q31_RS13260	COG2194	sulfuric ester hydrolase activity
C4Q31_RS13265	COG0006	proline dipeptidase activity
C4Q31_RS13270	COG0859	PFAM glycosyl transferase family 9
C4Q31_RS13290	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C4Q31_RS13295	COG0719	Fe-S assembly protein
C4Q31_RS13300	COG0450	alkyl hydroperoxide reductase
C4Q31_RS13335	COG0463	Glycosyl transferase, family 2
C4Q31_RS13375	COG2202	Pas domain
C4Q31_RS13375	COG2200	EAL domain
C4Q31_RS13375	COG2199	diguanylate cyclase activity
C4Q31_RS13380	COG0784	Response regulator, receiver
C4Q31_RS13380	COG4191	Histidine kinase
C4Q31_RS13385	COG0784	Response regulator, receiver
C4Q31_RS13390	COG4251	negative regulation of phosphorylation
C4Q31_RS13445	COG1757	Na H antiporter
C4Q31_RS13450	COG0564	pseudouridine synthase activity
C4Q31_RS13460	COG1304	FMN binding
C4Q31_RS13490	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C4Q31_RS13495	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
C4Q31_RS13590	COG0366	Alpha amylase catalytic
C4Q31_RS13595	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C4Q31_RS13605	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
C4Q31_RS13635	COG2003	Belongs to the UPF0758 family
C4Q31_RS13655	COG0612	Peptidase, M16
C4Q31_RS13685	COG0195	Participates in both transcription termination and antitermination
C4Q31_RS13700	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C4Q31_RS13700	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C4Q31_RS13735	COG0539	negative regulation of cytoplasmic translation
C4Q31_RS13735	COG2183	response to ionizing radiation
C4Q31_RS13750	COG0287	Prephenate dehydrogenase
C4Q31_RS13755	COG0077	Prephenate dehydratase
C4Q31_RS13755	COG1605	Chorismate mutase
C4Q31_RS13770	COG2201	protein-glutamate methylesterase activity
C4Q31_RS13780	COG2198	Histidine kinase
C4Q31_RS13780	COG0643	Histidine kinase
C4Q31_RS13795	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C4Q31_RS13800	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
C4Q31_RS13860	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C4Q31_RS13865	COG0508	dehydrogenase complex catalyzes the overall conversion of
C4Q31_RS13875	COG1234	tRNA 3'-trailer cleavage
C4Q31_RS13900	COG0095	Lipoate-protein ligase
C4Q31_RS14015	COG0741	lytic transglycosylase activity
C4Q31_RS14030	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
C4Q31_RS14035	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C4Q31_RS14085	COG4208	sulfate ABC transporter
C4Q31_RS14090	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
C4Q31_RS14100	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C4Q31_RS14100	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C4Q31_RS14115	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C4Q31_RS14130	COG1862	Preprotein translocase
C4Q31_RS14240	COG0318	PFAM AMP-dependent synthetase and ligase
C4Q31_RS14260	COG1136	(ABC) transporter
C4Q31_RS14270	COG0537	adenosine 5'-monophosphoramidase activity
C4Q31_RS14280	COG4191	Histidine kinase
C4Q31_RS14295	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C4Q31_RS14305	COG0631	protein serine/threonine phosphatase activity
C4Q31_RS14320	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
C4Q31_RS14325	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C4Q31_RS14330	COG0515	serine threonine protein kinase
C4Q31_RS14330	COG2815	serine threonine protein kinase
C4Q31_RS14350	COG4772	TonB-dependent receptor
C4Q31_RS14395	COG2267	carboxylic ester hydrolase activity
C4Q31_RS14400	COG2814	Major facilitator Superfamily
C4Q31_RS14435	COG0123	including yeast histone deacetylase and acetoin utilization protein
C4Q31_RS14450	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C4Q31_RS14570	COG2409	Drug exporters of the RND superfamily
C4Q31_RS14570	COG1033	growth of symbiont in host cell
C4Q31_RS14580	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C4Q31_RS14625	COG3177	Filamentation induced by cAMP protein fic
C4Q31_RS14645	COG4771	TonB-dependent receptor
C4Q31_RS14675	COG2843	Capsule synthesis protein
C4Q31_RS14690	COG4251	negative regulation of phosphorylation
C4Q31_RS14695	COG0784	Response regulator, receiver
C4Q31_RS14720	COG0385	Bile acid
C4Q31_RS14725	COG0697	spore germination
C4Q31_RS14745	COG0628	permease
C4Q31_RS14760	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C4Q31_RS14765	COG0673	inositol 2-dehydrogenase activity
C4Q31_RS14820	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
C4Q31_RS14845	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C4Q31_RS14855	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
C4Q31_RS14860	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
C4Q31_RS14865	COG3345	alpha-galactosidase
C4Q31_RS14895	COG0123	including yeast histone deacetylase and acetoin utilization protein
C4Q31_RS14900	COG0469	pyruvate kinase activity
C4Q31_RS14910	COG3447	MASE1 domain protein
C4Q31_RS14910	COG5002	protein histidine kinase activity
C4Q31_RS14910	COG5001	Diguanylate cyclase
C4Q31_RS14930	COG0436	Aminotransferase
C4Q31_RS14965	COG0463	Glycosyl transferase, family 2
C4Q31_RS15025	COG1331	Highly conserved protein containing a thioredoxin domain
C4Q31_RS15040	COG1408	metallophosphoesterase
C4Q31_RS15145	COG0285	dihydrofolate synthase activity
C4Q31_RS15185	COG1215	transferase activity, transferring glycosyl groups
C4Q31_RS15205	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
C4Q31_RS15210	COG0277	FAD linked oxidase domain protein
C4Q31_RS15215	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C4Q31_RS15215	COG3153	acetyltransferase
C4Q31_RS15260	COG1639	'signal transduction protein
C4Q31_RS15305	COG4943	cyclic-guanylate-specific phosphodiesterase activity
C4Q31_RS15335	COG0739	heme binding
C4Q31_RS15405	COG1573	uracil-dna glycosylase
C4Q31_RS15435	COG0720	synthase
C4Q31_RS15490	COG0584	glycerophosphoryl diester phosphodiesterase
C4Q31_RS15535	COG0745	RESPONSE REGULATOR receiver
C4Q31_RS15540	COG5002	protein histidine kinase activity
C4Q31_RS15600	COG1639	'signal transduction protein
C4Q31_RS15605	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
C4Q31_RS15610	COG0539	negative regulation of cytoplasmic translation
C4Q31_RS15685	COG0739	heme binding
C4Q31_RS15755	COG1573	uracil-dna glycosylase
C4Q31_RS15785	COG0720	synthase
C4Q31_RS15840	COG0584	glycerophosphoryl diester phosphodiesterase
C4Q31_RS15880	COG0745	RESPONSE REGULATOR receiver
C4Q31_RS15885	COG5002	protein histidine kinase activity
C4Q31_RS15930	COG2832	Protein of unknown function (DUF454)
C4Q31_RS15960	COG1815	bacterial-type flagellum-dependent cell motility
C4Q31_RS15990	COG0698	ribose 5-phosphate isomerase
C4Q31_RS16025	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
C4Q31_RS16075	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C4Q31_RS16090	COG0542	response to heat
C4Q31_RS16095	COG3869	Catalyzes the specific phosphorylation of arginine residues in
C4Q31_RS16105	COG4591	ABC-type transport system involved in lipoprotein release permease component
C4Q31_RS16145	COG0739	heme binding
C4Q31_RS16160	COG1192	Involved in chromosome partitioning
C4Q31_RS16185	COG4956	integral membrane protein (PIN domain superfamily)
C4Q31_RS16205	COG1845	cytochrome c oxidase, subunit III
C4Q31_RS16215	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C4Q31_RS16240	COG0473	3-isopropylmalate dehydrogenase activity
C4Q31_RS16250	COG2197	response regulator
C4Q31_RS16255	COG2205	protein histidine kinase activity
C4Q31_RS16285	COG0436	Aminotransferase
C4Q31_RS16300	COG1360	Flagellar Motor Protein
C4Q31_RS16340	COG0187	DNA topoisomerase II activity
C4Q31_RS16400	COG2304	oxidoreductase activity
C4Q31_RS16440	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C4Q31_RS16445	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C4Q31_RS16445	COG1648	precorrin-2 dehydrogenase activity
C4Q31_RS16450	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C4Q31_RS16450	COG1648	precorrin-2 dehydrogenase activity
C4Q31_RS16465	COG0175	sulfate reduction
C4Q31_RS16515	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C4Q31_RS16525	COG0460	homoserine dehydrogenase
C4Q31_RS16555	COG1132	(ABC) transporter
C4Q31_RS16560	COG0512	Glutamine amidotransferase of anthranilate synthase
C4Q31_RS16570	COG1960	acyl-CoA dehydrogenase activity
C4Q31_RS16575	COG0183	Belongs to the thiolase family
C4Q31_RS16595	COG1408	metallophosphoesterase
C4Q31_RS16605	COG0488	(ABC) transporter
C4Q31_RS16625	COG1595	DNA-templated transcription, initiation
C4Q31_RS16650	COG2885	chlorophyll binding
C4Q31_RS16655	COG0488	(ABC) transporter
C4Q31_RS16680	COG1234	tRNA 3'-trailer cleavage
C4Q31_RS16705	COG0656	L-ascorbic acid biosynthetic process
C4Q31_RS16715	COG1846	Transcriptional regulator
C4Q31_RS16720	COG2259	Doxx family
C4Q31_RS16740	COG2081	HI0933 family
C4Q31_RS16815	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C4Q31_RS16860	COG0183	Belongs to the thiolase family
C4Q31_RS16865	COG1250	3-hydroxyacyl-CoA dehydrogenase
C4Q31_RS16865	COG1024	Enoyl-CoA hydratase
C4Q31_RS16880	COG4174	ABC transporter (Permease)
C4Q31_RS16885	COG4239	(ABC) transporter, permease
C4Q31_RS16890	COG0444	Belongs to the ABC transporter superfamily
C4Q31_RS16895	COG4608	Belongs to the ABC transporter superfamily
C4Q31_RS16910	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
C4Q31_RS16945	COG0840	transmembrane signaling receptor activity
C4Q31_RS16970	COG0840	transmembrane signaling receptor activity
C4Q31_RS16980	COG3858	chitin binding
C4Q31_RS16980	COG1388	LysM domain
C4Q31_RS17000	COG0167	dihydroorotate dehydrogenase activity
C4Q31_RS17075	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C4Q31_RS17080	COG0649	NAD binding
C4Q31_RS17100	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C4Q31_RS17100	COG2111	Na H antiporter
C4Q31_RS17140	COG2937	Belongs to the GPAT DAPAT family
C4Q31_RS17155	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C4Q31_RS17160	COG1846	Transcriptional regulator
C4Q31_RS17165	COG0386	Belongs to the glutathione peroxidase family
C4Q31_RS17170	COG0693	protein deglycase activity
C4Q31_RS17225	COG0739	heme binding
C4Q31_RS17225	COG0741	lytic transglycosylase activity
C4Q31_RS17225	COG1196	nuclear chromosome segregation
C4Q31_RS17285	COG2363	Small membrane protein
C4Q31_RS17315	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
C4Q31_RS17325	COG0590	tRNA wobble adenosine to inosine editing
C4Q31_RS17335	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C4Q31_RS17355	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
C4Q31_RS17370	COG0084	hydrolase, TatD family'
C4Q31_RS17395	COG1475	DNA binding
C4Q31_RS17400	COG1192	Involved in chromosome partitioning
C4Q31_RS17410	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C4Q31_RS17435	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C4Q31_RS17450	COG1192	Involved in chromosome partitioning
C4Q31_RS17455	COG0542	response to heat
C4Q31_RS17485	COG1696	Membrane protein involved in D-alanine export
C4Q31_RS17510	COG0469	pyruvate kinase activity
C4Q31_RS17515	COG4884	unkown
C4Q31_RS17515	COG3831	ATPase activity
C4Q31_RS17540	COG2154	pterin-4-alpha-carbinolamine dehydratase
C4Q31_RS17545	COG0745	RESPONSE REGULATOR receiver
C4Q31_RS17580	COG0741	lytic transglycosylase activity
C4Q31_RS17585	COG5002	protein histidine kinase activity
C4Q31_RS17650	COG1238	metal cluster binding
C4Q31_RS17695	COG1028	Short-chain dehydrogenase reductase Sdr
C4Q31_RS17715	COG0069	glutamate synthase activity
C4Q31_RS17730	COG0427	acetyl-CoA hydrolase
C4Q31_RS17785	COG2801	Transposase and inactivated derivatives
C4Q31_RS17795	COG3415	Transposase
C4Q31_RS17795	COG2801	Transposase and inactivated derivatives
C4Q31_RS17900	COG0406	alpha-ribazole phosphatase activity
C4Q31_RS17930	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
C4Q31_RS18045	COG5398	heme oxygenase
C4Q31_RS18055	COG4771	TonB-dependent receptor
C4Q31_RS18090	COG1067	ATP-dependent peptidase activity
C4Q31_RS18095	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
C4Q31_RS18140	COG1694	Mazg nucleotide pyrophosphohydrolase
C4Q31_RS18145	COG0848	biopolymer transport protein
C4Q31_RS18180	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C4Q31_RS18195	COG0385	Bile acid
C4Q31_RS18200	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C4Q31_RS18220	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C4Q31_RS18225	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C4Q31_RS18225	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C4Q31_RS18230	COG1703	isobutyryl-CoA mutase activity
C4Q31_RS18260	COG0811	peptide transport
C4Q31_RS18350	COG4221	oxidoreductase activity
C4Q31_RS18365	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C4Q31_RS18375	COG1028	Short-chain dehydrogenase reductase Sdr
C4Q31_RS18385	COG2208	phosphoserine phosphatase activity
C4Q31_RS18385	COG2770	Histidine kinase
C4Q31_RS18405	COG1410	methionine synthase
C4Q31_RS18405	COG0646	methionine synthase
C4Q31_RS18420	COG0640	Transcriptional regulator
C4Q31_RS18435	COG0647	UMP catabolic process
C4Q31_RS18465	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
C4Q31_RS18490	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C4Q31_RS18505	COG5492	domain, Protein
C4Q31_RS18505	COG4932	domain protein
C4Q31_RS18570	COG4943	cyclic-guanylate-specific phosphodiesterase activity
C4Q31_RS18600	COG2200	EAL domain
C4Q31_RS18610	COG3706	GGDEF domain
C4Q31_RS18645	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C4Q31_RS18645	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C4Q31_RS18650	COG1703	isobutyryl-CoA mutase activity
C4Q31_RS18730	COG0326	Molecular chaperone. Has ATPase activity
C4Q31_RS18765	COG0714	Associated with various cellular activities
C4Q31_RS18810	COG4221	oxidoreductase activity
C4Q31_RS18825	COG1252	NADH dehydrogenase
C4Q31_RS18830	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C4Q31_RS18865	COG1475	DNA binding
C4Q31_RS18870	COG1192	Involved in chromosome partitioning
C4Q31_RS18895	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C4Q31_RS18900	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
C4Q31_RS18905	COG0745	RESPONSE REGULATOR receiver
C4Q31_RS18910	COG5002	protein histidine kinase activity
C4Q31_RS18920	COG0113	porphobilinogen synthase activity
C4Q31_RS18925	COG0181	hydroxymethylbilane synthase activity
C4Q31_RS18930	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
C4Q31_RS18940	COG0561	phosphatase activity
C4Q31_RS18945	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
C4Q31_RS18950	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity