locus-tag	class	description
E4414_RS00040	COG2949	membrane
E4414_RS00070	COG1960	acyl-CoA dehydrogenase activity
E4414_RS00075	COG2030	dehydratase
E4414_RS00125	COG5002	protein histidine kinase activity
E4414_RS00130	COG0745	RESPONSE REGULATOR receiver
E4414_RS00180	COG0494	nUDIX hydrolase
E4414_RS00185	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
E4414_RS00190	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
E4414_RS00250	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
E4414_RS00290	COG0538	isocitrate dehydrogenase activity
E4414_RS00300	COG0745	RESPONSE REGULATOR receiver
E4414_RS00310	COG3956	TIGRFAM MazG family protein
E4414_RS00350	COG4221	oxidoreductase activity
E4414_RS00355	COG1262	PFAM Formylglycine-generating sulfatase enzyme
E4414_RS00360	COG0513	Belongs to the DEAD box helicase family
E4414_RS00385	COG2271	Major facilitator Superfamily
E4414_RS00395	COG1560	Kdo2-lipid A biosynthetic process
E4414_RS00405	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
E4414_RS00480	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E4414_RS00485	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E4414_RS00580	COG0784	Response regulator, receiver
E4414_RS00580	COG2198	Histidine kinase
E4414_RS00580	COG2205	protein histidine kinase activity
E4414_RS00595	COG0456	acetyltransferase
E4414_RS00610	COG3263	regulation of cellular component size
E4414_RS00635	COG0584	glycerophosphoryl diester phosphodiesterase
E4414_RS00645	COG0494	nUDIX hydrolase
E4414_RS00665	COG0667	Aldo Keto reductase
E4414_RS00675	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E4414_RS00695	COG0534	Mate efflux family protein
E4414_RS00700	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
E4414_RS00725	COG1484	DNA-dependent DNA replication
E4414_RS00730	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
E4414_RS00730	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
E4414_RS00740	COG1605	Chorismate mutase
E4414_RS00740	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
E4414_RS00765	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E4414_RS00770	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E4414_RS00785	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
E4414_RS00820	COG1253	flavin adenine dinucleotide binding
E4414_RS00825	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
E4414_RS00850	COG1960	acyl-CoA dehydrogenase activity
E4414_RS00865	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4414_RS00880	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
E4414_RS00930	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
E4414_RS00940	COG4943	cyclic-guanylate-specific phosphodiesterase activity
E4414_RS00960	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E4414_RS00965	COG0596	Alpha beta hydrolase
E4414_RS00980	COG5002	protein histidine kinase activity
E4414_RS00985	COG4191	Histidine kinase
E4414_RS00995	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
E4414_RS01020	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
E4414_RS01040	COG1090	epimerase
E4414_RS01095	COG2197	response regulator
E4414_RS01100	COG4585	Histidine kinase
E4414_RS01125	COG0784	Response regulator, receiver
E4414_RS01125	COG2205	protein histidine kinase activity
E4414_RS01180	COG1309	transcriptional regulator
E4414_RS01190	COG1881	PFAM PEBP family protein
E4414_RS01220	COG0519	Catalyzes the synthesis of GMP from XMP
E4414_RS01280	COG3239	Fatty acid desaturase
E4414_RS01290	COG1040	competence protein
E4414_RS01335	COG2081	HI0933 family
E4414_RS01350	COG2259	Doxx family
E4414_RS01360	COG1846	Transcriptional regulator
E4414_RS01370	COG0531	amino acid
E4414_RS01475	COG3876	Protein conserved in bacteria
E4414_RS01510	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
E4414_RS01530	COG0666	response to abiotic stimulus
E4414_RS01560	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
E4414_RS01600	COG0586	Pfam SNARE associated Golgi protein
E4414_RS01630	COG0288	reversible hydration of carbon dioxide
E4414_RS01675	COG1937	Protein conserved in bacteria
E4414_RS01685	COG2217	Heavy metal translocating P-type atpase
E4414_RS01705	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E4414_RS01720	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E4414_RS01725	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
E4414_RS01760	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
E4414_RS01795	COG0514	ATP-dependent DNA helicase (RecQ)
E4414_RS01865	COG0285	dihydrofolate synthase activity
E4414_RS01895	COG0463	Glycosyl transferase, family 2
E4414_RS01900	COG1639	'signal transduction protein
E4414_RS01910	COG0539	negative regulation of cytoplasmic translation
E4414_RS01940	COG1366	Belongs to the anti-sigma-factor antagonist family
E4414_RS01955	COG1482	cell wall glycoprotein biosynthetic process
E4414_RS01995	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E4414_RS02000	COG1858	cytochrome C peroxidase
E4414_RS02040	COG0731	radical SAM domain protein
E4414_RS02050	COG0840	transmembrane signaling receptor activity
E4414_RS02055	COG0840	transmembrane signaling receptor activity
E4414_RS02110	COG0527	aspartate kinase activity
E4414_RS02115	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E4414_RS02145	COG3552	Protein containing von Willebrand factor type A (VWA) domain
E4414_RS02150	COG2425	protein containing a von Willebrand factor type A (vWA) domain
E4414_RS02155	COG0714	Associated with various cellular activities
E4414_RS02165	COG4884	unkown
E4414_RS02165	COG3831	ATPase activity
E4414_RS02230	COG0358	DNA primase activity
E4414_RS02235	COG4974	Belongs to the 'phage' integrase family
E4414_RS02240	COG1192	Involved in chromosome partitioning
E4414_RS02300	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
E4414_RS02310	COG1396	sequence-specific DNA binding
E4414_RS02315	COG0305	Participates in initiation and elongation during chromosome replication
E4414_RS02315	COG0358	DNA primase activity
E4414_RS02325	COG4974	Belongs to the 'phage' integrase family
E4414_RS02330	COG4974	Belongs to the 'phage' integrase family
E4414_RS02335	COG1192	Involved in chromosome partitioning
E4414_RS02355	COG2801	Transposase and inactivated derivatives
E4414_RS02440	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
E4414_RS02450	COG1396	sequence-specific DNA binding
E4414_RS02455	COG0305	Participates in initiation and elongation during chromosome replication
E4414_RS02455	COG0358	DNA primase activity
E4414_RS02465	COG4974	Belongs to the 'phage' integrase family
E4414_RS02470	COG4974	Belongs to the 'phage' integrase family
E4414_RS02475	COG1192	Involved in chromosome partitioning
E4414_RS02515	COG2801	Transposase and inactivated derivatives
E4414_RS02565	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
E4414_RS02575	COG1368	sulfuric ester hydrolase activity
E4414_RS02640	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E4414_RS02865	COG2314	TM2 domain
E4414_RS02885	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E4414_RS02905	COG0741	lytic transglycosylase activity
E4414_RS02950	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
E4414_RS02985	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4414_RS02990	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4414_RS03020	COG4585	Histidine kinase
E4414_RS03025	COG2197	response regulator
E4414_RS03050	COG0742	ribosomal rna small subunit methyltransferase
E4414_RS03090	COG0183	Belongs to the thiolase family
E4414_RS03250	COG1366	Belongs to the anti-sigma-factor antagonist family
E4414_RS03265	COG0028	Belongs to the TPP enzyme family
E4414_RS03275	COG1639	'signal transduction protein
E4414_RS03305	COG1595	DNA-templated transcription, initiation
E4414_RS03340	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E4414_RS03380	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E4414_RS03390	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E4414_RS03405	COG1846	Transcriptional regulator
E4414_RS03465	COG0123	including yeast histone deacetylase and acetoin utilization protein
E4414_RS03475	COG1024	Enoyl-CoA hydratase
E4414_RS03520	COG2814	Major facilitator Superfamily
E4414_RS03530	COG2267	carboxylic ester hydrolase activity
E4414_RS03580	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
E4414_RS03580	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
E4414_RS03595	COG0195	Participates in both transcription termination and antitermination
E4414_RS03625	COG0612	Peptidase, M16
E4414_RS03635	COG0705	Rhomboid family
E4414_RS03655	COG1331	Highly conserved protein containing a thioredoxin domain
E4414_RS03675	COG0514	ATP-dependent DNA helicase (RecQ)
E4414_RS03680	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
E4414_RS03685	COG1074	ATP-dependent DNA helicase activity
E4414_RS03690	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E4414_RS03695	COG1131	(ABC) transporter
E4414_RS03700	COG0842	Transport permease protein
E4414_RS03760	COG3831	ATPase activity
E4414_RS03760	COG4884	unkown
E4414_RS03765	COG3831	ATPase activity
E4414_RS03765	COG4884	unkown
E4414_RS03850	COG1487	ribonuclease activity
E4414_RS03885	COG0848	biopolymer transport protein
E4414_RS03895	COG0811	peptide transport
E4414_RS03995	COG3959	Transketolase, thiamine diphosphate binding domain
E4414_RS04010	COG0142	geranyltranstransferase activity
E4414_RS04155	COG1857	crispr-associated protein
E4414_RS04165	COG1203	CRISPR-associated helicase, Cas3
E4414_RS04245	COG0488	(ABC) transporter
E4414_RS04250	COG0656	L-ascorbic acid biosynthetic process
E4414_RS04265	COG1408	metallophosphoesterase
E4414_RS04310	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E4414_RS04365	COG2267	carboxylic ester hydrolase activity
E4414_RS04380	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E4414_RS04430	COG0183	Belongs to the thiolase family
E4414_RS04470	COG1262	PFAM Formylglycine-generating sulfatase enzyme
E4414_RS04500	COG2815	serine threonine protein kinase
E4414_RS04500	COG0515	serine threonine protein kinase
E4414_RS04525	COG2205	protein histidine kinase activity
E4414_RS04530	COG0745	RESPONSE REGULATOR receiver
E4414_RS04580	COG1652	LysM domain
E4414_RS04585	COG1366	Belongs to the anti-sigma-factor antagonist family
E4414_RS04650	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E4414_RS04665	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
E4414_RS04690	COG4932	domain protein
E4414_RS04690	COG5492	domain, Protein
E4414_RS04710	COG0463	Glycosyl transferase, family 2
E4414_RS04770	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4414_RS04775	COG0436	Aminotransferase
E4414_RS04845	COG4884	unkown
E4414_RS04845	COG3831	ATPase activity
E4414_RS04910	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
E4414_RS04915	COG1704	LemA family
E4414_RS04970	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
E4414_RS04970	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
E4414_RS05015	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E4414_RS05015	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
E4414_RS05045	COG1136	(ABC) transporter
E4414_RS05050	COG2385	sporulation resulting in formation of a cellular spore
E4414_RS05080	COG1858	cytochrome C peroxidase
E4414_RS05105	COG1215	transferase activity, transferring glycosyl groups
E4414_RS05120	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
E4414_RS05145	COG1988	membrane-bound metal-dependent
E4414_RS05155	COG0596	Alpha beta hydrolase
E4414_RS05165	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
E4414_RS05165	COG1703	isobutyryl-CoA mutase activity
E4414_RS05165	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
E4414_RS05170	COG0204	Acyl-transferase
E4414_RS05180	COG0671	phosphoesterase, PA-phosphatase related
E4414_RS05195	COG4565	transcriptional regulatory protein
E4414_RS05230	COG1501	Belongs to the glycosyl hydrolase 31 family
E4414_RS05235	COG3011	Protein conserved in bacteria
E4414_RS05270	COG0038	chloride channel
E4414_RS05275	COG3706	GGDEF domain
E4414_RS05300	COG3706	GGDEF domain
E4414_RS05310	COG0469	pyruvate kinase activity
E4414_RS05315	COG0123	including yeast histone deacetylase and acetoin utilization protein
E4414_RS05345	COG3345	alpha-galactosidase
E4414_RS05350	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
E4414_RS05355	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
E4414_RS05370	COG1028	Short-chain dehydrogenase reductase Sdr
E4414_RS05395	COG0739	heme binding
E4414_RS05415	COG1396	sequence-specific DNA binding
E4414_RS05445	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E4414_RS05465	COG2226	methyltransferase
E4414_RS05505	COG0850	regulation of cytokinetic process
E4414_RS05550	COG1054	Belongs to the UPF0176 family
E4414_RS05575	COG0596	Alpha beta hydrolase
E4414_RS05600	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
E4414_RS05610	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
E4414_RS05675	COG4251	negative regulation of phosphorylation
E4414_RS05680	COG0784	Response regulator, receiver
E4414_RS05685	COG4191	Histidine kinase
E4414_RS05685	COG0784	Response regulator, receiver
E4414_RS05780	COG0450	alkyl hydroperoxide reductase
E4414_RS05785	COG0719	Fe-S assembly protein
E4414_RS05830	COG0598	Magnesium transport protein CorA
E4414_RS05845	COG1309	transcriptional regulator
E4414_RS05880	COG0356	it plays a direct role in the translocation of protons across the membrane
E4414_RS05885	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
E4414_RS06010	COG0768	penicillin binding
E4414_RS06015	COG0772	Belongs to the SEDS family
E4414_RS06045	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
E4414_RS06120	COG0439	Biotin carboxylase
E4414_RS06125	COG0511	ligase activity, forming carbon-carbon bonds
E4414_RS06135	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
E4414_RS06155	COG1959	2 iron, 2 sulfur cluster binding
E4414_RS06165	COG2070	2-Nitropropane dioxygenase
E4414_RS06220	COG2181	nitrate reductase activity
E4414_RS06220	COG0247	lactate metabolic process
E4414_RS06240	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
E4414_RS06275	COG1181	Belongs to the D-alanine--D-alanine ligase family
E4414_RS06300	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
E4414_RS06305	COG0116	Belongs to the methyltransferase superfamily
E4414_RS06305	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
E4414_RS06315	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E4414_RS06320	COG0859	PFAM glycosyl transferase family 9
E4414_RS06325	COG0006	proline dipeptidase activity
E4414_RS06345	COG1473	amidohydrolase
E4414_RS06385	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
E4414_RS06400	COG1959	2 iron, 2 sulfur cluster binding
E4414_RS06400	COG1295	ribonuclease BN
E4414_RS06405	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E4414_RS06485	COG4774	siderophore transport
E4414_RS06495	COG1960	acyl-CoA dehydrogenase activity
E4414_RS06520	COG3958	Transketolase
E4414_RS06530	COG1063	alcohol dehydrogenase
E4414_RS06540	COG2030	dehydratase
E4414_RS06555	COG0339	signal peptide processing
E4414_RS06565	COG0625	glutathione transferase activity
E4414_RS06570	COG1028	Short-chain dehydrogenase reductase Sdr
E4414_RS06585	COG0688	phosphatidylethanolamine metabolic process
E4414_RS06595	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E4414_RS06595	COG1776	CheC inhibitor of MCP methylation
E4414_RS06605	COG1338	Plays a role in the flagellum-specific transport system
E4414_RS06610	COG1987	bacterial-type flagellum assembly
E4414_RS06620	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E4414_RS06630	COG1419	protein localization to endoplasmic reticulum
E4414_RS06645	COG1191	sigma factor activity
E4414_RS06670	COG0194	GDP metabolic process
E4414_RS06700	COG1766	The M ring may be actively involved in energy transduction
E4414_RS06710	COG1317	bacterial-type flagellum organization
E4414_RS06740	COG2089	acid synthase
E4414_RS06775	COG0840	transmembrane signaling receptor activity
E4414_RS06785	COG0028	Belongs to the TPP enzyme family
E4414_RS06790	COG0440	acetolactate synthase activity
E4414_RS06805	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E4414_RS06810	COG1472	Belongs to the glycosyl hydrolase 3 family
E4414_RS06815	COG2755	lipolytic protein G-D-S-L family
E4414_RS06860	COG0724	RNA recognition motif
E4414_RS06880	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
E4414_RS06920	COG0488	(ABC) transporter
E4414_RS06945	COG4251	negative regulation of phosphorylation
E4414_RS06950	COG4565	transcriptional regulatory protein
E4414_RS06985	COG5001	Diguanylate cyclase
E4414_RS06985	COG2203	Gaf domain
E4414_RS06985	COG3706	GGDEF domain
E4414_RS06985	COG4251	negative regulation of phosphorylation
E4414_RS06990	COG2379	hydroxypyruvate reductase
E4414_RS07020	COG0708	Exodeoxyribonuclease III
E4414_RS07105	COG0492	ferredoxin-NADP+ reductase activity
E4414_RS07220	COG4555	ABC transporter
E4414_RS07230	COG2226	methyltransferase
E4414_RS07245	COG0024	Methionine aminopeptidase
E4414_RS07260	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
E4414_RS07340	COG2208	phosphoserine phosphatase activity
E4414_RS07345	COG1366	Belongs to the anti-sigma-factor antagonist family
E4414_RS07350	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
E4414_RS07355	COG0439	Biotin carboxylase
E4414_RS07385	COG0840	transmembrane signaling receptor activity
E4414_RS07385	COG3290	protein histidine kinase activity
E4414_RS07390	COG2198	Histidine kinase
E4414_RS07390	COG0643	Histidine kinase
E4414_RS07400	COG0745	RESPONSE REGULATOR receiver
E4414_RS07405	COG2201	protein-glutamate methylesterase activity
E4414_RS07410	COG2205	protein histidine kinase activity
E4414_RS07445	COG2096	Adenosyltransferase
E4414_RS07450	COG3104	oligopeptide transport
E4414_RS07455	COG0791	NLP P60 protein
E4414_RS07470	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
E4414_RS07470	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
E4414_RS07500	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
E4414_RS07515	COG5000	phosphorelay sensor kinase activity
E4414_RS07520	COG2204	response regulator
E4414_RS07530	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
E4414_RS07540	COG2815	serine threonine protein kinase
E4414_RS07540	COG0515	serine threonine protein kinase
E4414_RS07575	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
E4414_RS07615	COG0739	heme binding
E4414_RS07630	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
E4414_RS07635	COG1459	type II secretion system
E4414_RS07740	COG1193	negative regulation of DNA recombination
E4414_RS07810	COG0489	protein tyrosine kinase activity
E4414_RS07820	COG0163	prenyltransferase activity
E4414_RS07825	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
E4414_RS07845	COG0012	GTP binding
E4414_RS07855	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
E4414_RS07860	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4414_RS07865	COG0640	Transcriptional regulator
E4414_RS07870	COG1028	Short-chain dehydrogenase reductase Sdr
E4414_RS07875	COG1639	'signal transduction protein
E4414_RS07885	COG0497	DNA recombination
E4414_RS07890	COG0811	peptide transport
E4414_RS07895	COG0848	biopolymer transport protein
E4414_RS07900	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E4414_RS07915	COG1218	3'(2'),5'-bisphosphate nucleotidase
E4414_RS07930	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E4414_RS07935	COG1022	Amp-dependent synthetase and ligase
E4414_RS07945	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E4414_RS07955	COG4221	oxidoreductase activity
E4414_RS07980	COG4335	DNA alkylation repair
E4414_RS07995	COG2133	pyrroloquinoline quinone binding
E4414_RS08025	COG1187	pseudouridine synthase activity
E4414_RS08065	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
E4414_RS08070	COG1516	flagellar protein fliS
E4414_RS08095	COG0586	Pfam SNARE associated Golgi protein
E4414_RS08110	COG1104	cysteine desulfurase activity
E4414_RS08130	COG1024	Enoyl-CoA hydratase
E4414_RS08140	COG0277	FAD linked oxidase domain protein
E4414_RS08145	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
E4414_RS08210	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
E4414_RS08560	COG0840	transmembrane signaling receptor activity
E4414_RS08575	COG4771	TonB-dependent receptor
E4414_RS08590	COG0726	polysaccharide deacetylase
E4414_RS08600	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
E4414_RS08625	COG0358	DNA primase activity
E4414_RS08680	COG2239	Acts as a magnesium transporter
E4414_RS08685	COG1360	Flagellar Motor Protein
E4414_RS08705	COG0616	signal peptide processing
E4414_RS08720	COG0009	L-threonylcarbamoyladenylate synthase
E4414_RS08770	COG1902	pentaerythritol trinitrate reductase activity
E4414_RS08770	COG0446	pyridine nucleotide-disulphide oxidoreductase
E4414_RS08810	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
E4414_RS08820	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E4414_RS08825	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E4414_RS08840	COG0312	modulator of DNA gyrase
E4414_RS08870	COG1022	Amp-dependent synthetase and ligase
E4414_RS08905	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E4414_RS08925	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
E4414_RS08935	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
E4414_RS08970	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E4414_RS09010	COG0560	Phosphoserine phosphatase
E4414_RS09025	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
E4414_RS09035	COG0156	8-amino-7-oxononanoate synthase activity
E4414_RS09045	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E4414_RS09045	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
E4414_RS09060	COG0083	homoserine kinase activity
E4414_RS09070	COG2267	carboxylic ester hydrolase activity
E4414_RS09080	COG0436	Aminotransferase
E4414_RS09095	COG0616	signal peptide processing
E4414_RS09130	COG1234	tRNA 3'-trailer cleavage
E4414_RS09145	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E4414_RS09150	COG1131	(ABC) transporter
E4414_RS09155	COG0842	Transport permease protein
E4414_RS09175	COG0271	Belongs to the BolA IbaG family
E4414_RS09180	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
E4414_RS09200	COG0405	Gamma-glutamyltransferase
E4414_RS09205	COG0542	response to heat
E4414_RS09220	COG1595	DNA-templated transcription, initiation
E4414_RS09235	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E4414_RS09240	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
E4414_RS09265	COG0444	Belongs to the ABC transporter superfamily
E4414_RS09280	COG0463	Glycosyl transferase, family 2
E4414_RS09340	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E4414_RS09355	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
E4414_RS09375	COG0330	HflC and HflK could
E4414_RS09380	COG0330	HflC and HflK could
E4414_RS09390	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E4414_RS09425	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E4414_RS09425	COG2813	Specifically methylates the guanine in position
E4414_RS09440	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
E4414_RS09445	COG1127	ABC transporter
E4414_RS09455	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
E4414_RS09470	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
E4414_RS09480	COG0772	Belongs to the SEDS family
E4414_RS09645	COG4452	Inner membrane protein CreD
E4414_RS09660	COG0745	RESPONSE REGULATOR receiver
E4414_RS09665	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
E4414_RS09670	COG0508	dehydrogenase complex catalyzes the overall conversion of
E4414_RS09670	COG0022	dehydrogenase e1 component
E4414_RS09675	COG0508	dehydrogenase complex catalyzes the overall conversion of
E4414_RS09680	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E4414_RS09720	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E4414_RS09740	COG1649	PFAM Uncharacterised BCR, COG1649
E4414_RS09740	COG0726	polysaccharide deacetylase
E4414_RS09760	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
E4414_RS09765	COG0352	thiamine-phosphate diphosphorylase activity
E4414_RS09775	COG1385	rRNA (uridine-N3-)-methyltransferase activity
E4414_RS09795	COG2200	EAL domain
E4414_RS09800	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
E4414_RS09835	COG1028	Short-chain dehydrogenase reductase Sdr
E4414_RS09865	COG0617	tRNA 3'-terminal CCA addition
E4414_RS09910	COG0519	Catalyzes the synthesis of GMP from XMP
E4414_RS09915	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E4414_RS10065	COG1960	acyl-CoA dehydrogenase activity
E4414_RS10075	COG3118	belongs to the thioredoxin family
E4414_RS10090	COG0805	protein transport
E4414_RS10105	COG0724	RNA recognition motif
E4414_RS10125	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
E4414_RS10140	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E4414_RS10170	COG2267	carboxylic ester hydrolase activity
E4414_RS10190	COG1053	succinate dehydrogenase
E4414_RS10280	COG0733	neurotransmitter:sodium symporter activity
E4414_RS10285	COG1199	ATP-dependent helicase activity
E4414_RS10345	COG3458	cephalosporin-C deacetylase activity
E4414_RS10355	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E4414_RS10365	COG4191	Histidine kinase
E4414_RS10380	COG0735	belongs to the Fur family
E4414_RS10390	COG4786	Flagellar basal body rod
E4414_RS10410	COG2801	Transposase and inactivated derivatives
E4414_RS10430	COG4974	Belongs to the 'phage' integrase family
E4414_RS10530	COG2801	Transposase and inactivated derivatives
E4414_RS10610	COG2205	protein histidine kinase activity
E4414_RS10625	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
E4414_RS10710	COG1639	'signal transduction protein
E4414_RS10715	COG1119	ATPase activity
E4414_RS10730	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E4414_RS10750	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
E4414_RS10760	COG4251	negative regulation of phosphorylation
E4414_RS10765	COG0745	RESPONSE REGULATOR receiver
E4414_RS10780	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E4414_RS10830	COG4191	Histidine kinase
E4414_RS10830	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4414_RS10870	COG1381	Involved in DNA repair and RecF pathway recombination
E4414_RS10880	COG1480	7TM receptor with intracellular HD hydrolase
E4414_RS10885	COG1702	phosphate starvation-inducible protein PhoH
E4414_RS10895	COG0305	Participates in initiation and elongation during chromosome replication
E4414_RS10910	COG0629	single-stranded DNA binding
E4414_RS10940	COG0471	metal ion transport
E4414_RS10970	COG2433	Pfam Transposase IS66
E4414_RS10975	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
E4414_RS10980	COG1088	dTDP-glucose 4,6-dehydratase activity
E4414_RS11000	COG0463	Glycosyl transferase, family 2
E4414_RS11000	COG1216	Glycosyl transferase, family 2
E4414_RS11020	COG1442	glycosyl transferase family 8
E4414_RS11045	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
E4414_RS11070	COG0438	transferase activity, transferring glycosyl groups
E4414_RS11105	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
E4414_RS11115	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
E4414_RS11120	COG1028	Short-chain dehydrogenase reductase Sdr
E4414_RS11140	COG1028	Short-chain dehydrogenase reductase Sdr
E4414_RS11145	COG3836	Belongs to the HpcH HpaI aldolase family
E4414_RS11155	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
E4414_RS11155	COG0517	IMP dehydrogenase activity
E4414_RS11160	COG2877	3-deoxy-8-phosphooctulonate synthase activity
E4414_RS11200	COG2089	acid synthase
E4414_RS11210	COG3980	spore coat polysaccharide biosynthesis protein
E4414_RS11220	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
E4414_RS11240	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E4414_RS11250	COG1132	(ABC) transporter
E4414_RS11265	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
E4414_RS11270	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E4414_RS11285	COG2813	Specifically methylates the guanine in position
E4414_RS11290	COG0494	nUDIX hydrolase
E4414_RS11305	COG3958	Transketolase
E4414_RS11310	COG3959	Transketolase, thiamine diphosphate binding domain
E4414_RS11330	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4414_RS11335	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
E4414_RS11335	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
E4414_RS11340	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
E4414_RS11345	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4414_RS11350	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
E4414_RS11360	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4414_RS11400	COG0071	Belongs to the small heat shock protein (HSP20) family
E4414_RS11425	COG1999	signal sequence binding
E4414_RS11465	COG0475	glutathione-regulated potassium exporter activity
E4414_RS11490	COG1073	alpha beta
E4414_RS11535	COG1830	Aldolase
E4414_RS11555	COG5002	protein histidine kinase activity
E4414_RS11630	COG0793	Belongs to the peptidase S41A family
E4414_RS11635	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
E4414_RS11730	COG1757	Na H antiporter
E4414_RS11735	COG0564	pseudouridine synthase activity
E4414_RS11745	COG1304	FMN binding
E4414_RS11780	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
E4414_RS11785	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
E4414_RS11850	COG0366	Alpha amylase catalytic
E4414_RS11865	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
E4414_RS11885	COG2003	Belongs to the UPF0758 family
E4414_RS11920	COG0793	Belongs to the peptidase S41A family
E4414_RS11980	COG0577	efflux transmembrane transporter activity
E4414_RS11980	COG1136	(ABC) transporter
E4414_RS11990	COG0537	adenosine 5'-monophosphoramidase activity
E4414_RS12030	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E4414_RS12040	COG0631	protein serine/threonine phosphatase activity
E4414_RS12045	COG1028	Short-chain dehydrogenase reductase Sdr
E4414_RS12055	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
E4414_RS12060	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E4414_RS12110	COG0095	Lipoate-protein ligase
E4414_RS12170	COG1033	growth of symbiont in host cell
E4414_RS12170	COG2409	Drug exporters of the RND superfamily
E4414_RS12195	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4414_RS12205	COG2339	peptidase activity
E4414_RS12240	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
E4414_RS12240	COG2755	lipolytic protein G-D-S-L family
E4414_RS12255	COG1217	gtp-binding protein TYPA
E4414_RS12270	COG1741	Belongs to the pirin family
E4414_RS12345	COG4771	TonB-dependent receptor
E4414_RS12365	COG2843	Capsule synthesis protein
E4414_RS12375	COG4251	negative regulation of phosphorylation
E4414_RS12380	COG0784	Response regulator, receiver
E4414_RS12395	COG0385	Bile acid
E4414_RS12405	COG0697	spore germination
E4414_RS12410	COG0628	permease
E4414_RS12425	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
E4414_RS12430	COG0673	inositol 2-dehydrogenase activity
E4414_RS12440	COG0154	amidase activity
E4414_RS12530	COG0174	glutamine synthetase
E4414_RS12615	COG0714	Associated with various cellular activities
E4414_RS12620	COG0436	Aminotransferase
E4414_RS12660	COG0577	efflux transmembrane transporter activity
E4414_RS12660	COG1136	(ABC) transporter
E4414_RS12680	COG1368	sulfuric ester hydrolase activity
E4414_RS12755	COG0539	negative regulation of cytoplasmic translation
E4414_RS12770	COG0287	Prephenate dehydrogenase
E4414_RS12775	COG1605	Chorismate mutase
E4414_RS12775	COG0077	Prephenate dehydratase
E4414_RS12780	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
E4414_RS12790	COG2201	protein-glutamate methylesterase activity
E4414_RS12800	COG2198	Histidine kinase
E4414_RS12800	COG0643	Histidine kinase
E4414_RS12810	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
E4414_RS12815	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
E4414_RS12880	COG0326	Molecular chaperone. Has ATPase activity
E4414_RS12910	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E4414_RS12970	COG0861	Integral membrane protein TerC family
E4414_RS13015	COG1024	Enoyl-CoA hydratase
E4414_RS13050	COG0840	transmembrane signaling receptor activity
E4414_RS13060	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
E4414_RS13085	COG5001	Diguanylate cyclase
E4414_RS13145	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
E4414_RS13150	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E4414_RS13175	COG0515	serine threonine protein kinase
E4414_RS13205	COG4208	sulfate ABC transporter
E4414_RS13215	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
E4414_RS13240	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
E4414_RS13240	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
E4414_RS13265	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E4414_RS13270	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E4414_RS13280	COG1862	Preprotein translocase
E4414_RS13330	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
E4414_RS13355	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E4414_RS13445	COG0484	heat shock protein binding
E4414_RS13460	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
E4414_RS13485	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E4414_RS13510	COG0640	Transcriptional regulator
E4414_RS13710	COG4942	peptidase
E4414_RS13710	COG1388	LysM domain
E4414_RS13755	COG1024	Enoyl-CoA hydratase
E4414_RS13795	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
E4414_RS13830	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
E4414_RS13840	COG0386	Belongs to the glutathione peroxidase family
E4414_RS13855	COG4772	TonB-dependent receptor
E4414_RS13890	COG0243	molybdopterin cofactor binding
E4414_RS13940	COG1262	PFAM Formylglycine-generating sulfatase enzyme
E4414_RS14000	COG0750	zinc metalloprotease
E4414_RS14000	COG0750	zinc metalloprotease
E4414_RS14010	COG0575	Belongs to the CDS family
E4414_RS14065	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
E4414_RS14080	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E4414_RS14100	COG2801	Transposase and inactivated derivatives
E4414_RS14105	COG1090	epimerase
E4414_RS14150	COG2433	Pfam Transposase IS66
E4414_RS14265	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
E4414_RS14285	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
E4414_RS14290	COG1138	Cytochrome C-type biogenesis protein
E4414_RS14320	COG0625	glutathione transferase activity
E4414_RS14365	COG1024	Enoyl-CoA hydratase
E4414_RS14525	COG0612	Peptidase, M16
E4414_RS14530	COG0612	Peptidase, M16
E4414_RS14565	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
E4414_RS14645	COG0250	Participates in transcription elongation, termination and antitermination
E4414_RS14650	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E4414_RS14700	COG0860	N-Acetylmuramoyl-L-alanine amidase
E4414_RS14705	COG0513	Belongs to the DEAD box helicase family
E4414_RS14710	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E4414_RS14740	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
E4414_RS14760	COG0196	riboflavin kinase activity
E4414_RS14785	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
E4414_RS14790	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
E4414_RS14795	COG0739	heme binding
E4414_RS14805	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
E4414_RS14810	COG0277	FAD linked oxidase domain protein
E4414_RS14830	COG4772	TonB-dependent receptor
E4414_RS14920	COG1028	Short-chain dehydrogenase reductase Sdr
E4414_RS15015	COG0840	transmembrane signaling receptor activity
E4414_RS15030	COG1858	cytochrome C peroxidase
E4414_RS15040	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
E4414_RS15065	COG1116	anion transmembrane transporter activity
E4414_RS15085	COG4608	Belongs to the ABC transporter superfamily
E4414_RS15100	COG1715	Restriction endonuclease
E4414_RS15150	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
E4414_RS15155	COG0477	Major facilitator Superfamily
E4414_RS15180	COG2226	methyltransferase
E4414_RS15210	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E4414_RS15250	COG4943	cyclic-guanylate-specific phosphodiesterase activity
E4414_RS15265	COG2801	Transposase and inactivated derivatives
E4414_RS15295	COG0822	iron-sulfur transferase activity
E4414_RS15300	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E4414_RS15305	COG2146	nitrite reductase [NAD(P)H] activity
E4414_RS15310	COG0719	Fe-S assembly protein
E4414_RS15315	COG0396	ATPase activity
E4414_RS15330	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
E4414_RS15350	COG1366	Belongs to the anti-sigma-factor antagonist family
E4414_RS15365	COG1360	Flagellar Motor Protein
E4414_RS15375	COG1582	Flagellar protein (FlbD)
E4414_RS15390	COG3384	dioxygenase
E4414_RS15405	COG0758	DNA mediated transformation
E4414_RS15425	COG0456	acetyltransferase
E4414_RS15470	COG0783	Belongs to the Dps family
E4414_RS15485	COG3119	arylsulfatase activity
E4414_RS15495	COG2030	dehydratase
E4414_RS15530	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
E4414_RS15555	COG1324	tolerance protein
E4414_RS15570	COG0004	ammonium transporteR
E4414_RS15575	COG0121	glutamine amidotransferase
E4414_RS15590	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E4414_RS15590	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E4414_RS15605	COG1960	acyl-CoA dehydrogenase activity
E4414_RS15615	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
E4414_RS15615	COG0512	Glutamine amidotransferase of anthranilate synthase
E4414_RS15620	COG1132	(ABC) transporter
E4414_RS15670	COG0460	homoserine dehydrogenase
E4414_RS15705	COG1999	signal sequence binding
E4414_RS15740	COG2205	protein histidine kinase activity
E4414_RS15740	COG0784	Response regulator, receiver
E4414_RS15765	COG0596	Alpha beta hydrolase
E4414_RS15790	COG1573	uracil-dna glycosylase
E4414_RS15815	COG1960	acyl-CoA dehydrogenase activity
E4414_RS15845	COG0488	(ABC) transporter
E4414_RS15850	COG2885	chlorophyll binding
E4414_RS15870	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
E4414_RS15875	COG4166	transmembrane transport
E4414_RS15880	COG1132	(ABC) transporter
E4414_RS15885	COG1663	tetraacyldisaccharide 4'-kinase activity
E4414_RS15910	COG0768	penicillin binding
E4414_RS15940	COG0673	inositol 2-dehydrogenase activity
E4414_RS15945	COG1678	Uncharacterized ACR, COG1678
E4414_RS15960	COG4181	ATPase activity
E4414_RS16025	COG1192	Involved in chromosome partitioning
E4414_RS16030	COG4974	Belongs to the 'phage' integrase family
E4414_RS16035	COG4974	Belongs to the 'phage' integrase family
E4414_RS16045	COG2801	Transposase and inactivated derivatives
E4414_RS16050	COG0305	Participates in initiation and elongation during chromosome replication
E4414_RS16050	COG0358	DNA primase activity
E4414_RS16055	COG3620	sequence-specific DNA binding
E4414_RS16060	COG2801	Transposase and inactivated derivatives
E4414_RS16080	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
E4414_RS16145	COG1192	Involved in chromosome partitioning
E4414_RS16150	COG4974	Belongs to the 'phage' integrase family
E4414_RS16155	COG4974	Belongs to the 'phage' integrase family
E4414_RS16165	COG2801	Transposase and inactivated derivatives
E4414_RS16170	COG0305	Participates in initiation and elongation during chromosome replication
E4414_RS16170	COG0358	DNA primase activity
E4414_RS16175	COG3620	sequence-specific DNA binding
E4414_RS16180	COG2801	Transposase and inactivated derivatives
E4414_RS16200	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
E4414_RS16300	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E4414_RS16325	COG1639	'signal transduction protein
E4414_RS16385	COG0724	RNA recognition motif
E4414_RS16445	COG5492	domain, Protein
E4414_RS16445	COG4932	domain protein
E4414_RS16450	COG4932	domain protein
E4414_RS16450	COG5492	domain, Protein
E4414_RS16470	COG0346	lactoylglutathione lyase activity
E4414_RS16520	COG1215	transferase activity, transferring glycosyl groups
E4414_RS16550	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E4414_RS16560	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
E4414_RS16565	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
E4414_RS16575	COG0004	ammonium transporteR
E4414_RS16580	COG0347	Belongs to the P(II) protein family
E4414_RS16625	COG0193	aminoacyl-tRNA hydrolase activity
E4414_RS16640	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
E4414_RS16685	COG0210	DNA helicase
E4414_RS16790	COG0183	Belongs to the thiolase family
E4414_RS16810	COG1408	metallophosphoesterase
E4414_RS16820	COG0488	(ABC) transporter
E4414_RS16930	COG2326	polyphosphate kinase activity
E4414_RS16975	COG1960	acyl-CoA dehydrogenase activity
E4414_RS16985	COG2086	electron transfer activity
E4414_RS16990	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
E4414_RS17005	COG0180	Tryptophanyl-tRNA synthetase
E4414_RS17025	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
E4414_RS17030	COG1639	'signal transduction protein
E4414_RS17040	COG1131	(ABC) transporter
E4414_RS17075	COG1366	Belongs to the anti-sigma-factor antagonist family
E4414_RS17105	COG0542	response to heat
E4414_RS17120	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E4414_RS17180	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
E4414_RS17215	COG0698	ribose 5-phosphate isomerase
E4414_RS17290	COG2832	Protein of unknown function (DUF454)
E4414_RS17315	COG1815	bacterial-type flagellum-dependent cell motility
E4414_RS17355	COG0584	glycerophosphoryl diester phosphodiesterase
E4414_RS17395	COG0720	synthase
E4414_RS17415	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
E4414_RS17420	COG0142	geranyltranstransferase activity
E4414_RS17480	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E4414_RS17495	COG3942	CHAP domain
E4414_RS17500	COG0402	S-adenosylhomocysteine deaminase activity
E4414_RS17510	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E4414_RS17560	COG1966	Carbon starvation protein
E4414_RS17570	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
E4414_RS17570	COG0617	tRNA 3'-terminal CCA addition
E4414_RS17570	COG0517	IMP dehydrogenase activity
E4414_RS17575	COG0604	alcohol dehydrogenase
E4414_RS17630	COG3361	conserved protein (COG2071)
E4414_RS17645	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
E4414_RS17650	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E4414_RS17675	COG4591	ABC-type transport system involved in lipoprotein release permease component
E4414_RS17730	COG0739	heme binding
E4414_RS17755	COG1192	Involved in chromosome partitioning
E4414_RS17780	COG4956	integral membrane protein (PIN domain superfamily)
E4414_RS17805	COG1845	cytochrome c oxidase, subunit III
E4414_RS17815	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
E4414_RS17870	COG0483	inositol monophosphate 1-phosphatase activity
E4414_RS17900	COG0564	pseudouridine synthase activity
E4414_RS18090	COG0281	malic enzyme
E4414_RS18090	COG0280	phosphate acetyltransferase
E4414_RS18100	COG1847	R3H domain protein
E4414_RS18115	COG0594	ribonuclease P activity
E4414_RS18140	COG3977	Valine--pyruvate aminotransferase
E4414_RS18150	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
E4414_RS18165	COG1595	DNA-templated transcription, initiation
E4414_RS18180	COG1034	ATP synthesis coupled electron transport
E4414_RS18200	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
E4414_RS18205	COG1132	(ABC) transporter
E4414_RS18280	COG1162	GTPase activity
E4414_RS18285	COG3852	Histidine kinase
E4414_RS18305	COG0351	phosphomethylpyrimidine kinase
E4414_RS18305	COG0352	thiamine-phosphate diphosphorylase activity
E4414_RS18415	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
E4414_RS18435	COG1022	Amp-dependent synthetase and ligase
E4414_RS18550	COG2226	methyltransferase
E4414_RS18560	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E4414_RS18585	COG1024	Enoyl-CoA hydratase
E4414_RS18600	COG2205	protein histidine kinase activity
E4414_RS18620	COG1301	dicarboxylic acid transport
E4414_RS18625	COG0534	Mate efflux family protein
E4414_RS18645	COG1045	serine acetyltransferase
E4414_RS18650	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
E4414_RS18690	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
E4414_RS18695	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4414_RS18705	COG0840	transmembrane signaling receptor activity
E4414_RS18705	COG0840	transmembrane signaling receptor activity
E4414_RS18750	COG0557	exoribonuclease II activity
E4414_RS18755	COG1214	PFAM Peptidase M22, glycoprotease
E4414_RS18760	COG0802	atpase or kinase
E4414_RS18765	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
E4414_RS18785	COG0483	inositol monophosphate 1-phosphatase activity
E4414_RS18835	COG0009	L-threonylcarbamoyladenylate synthase
E4414_RS18875	COG2204	response regulator
E4414_RS18915	COG0187	DNA topoisomerase II activity
E4414_RS18930	COG0592	DNA-directed DNA polymerase activity
E4414_RS18945	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
E4414_RS18960	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E4414_RS18970	COG1192	Involved in chromosome partitioning
E4414_RS18975	COG1475	DNA binding
E4414_RS19005	COG0084	hydrolase, TatD family'
E4414_RS19020	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
E4414_RS19040	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
E4414_RS19060	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
E4414_RS19090	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
E4414_RS19100	COG2363	Small membrane protein
E4414_RS19140	COG0741	lytic transglycosylase activity
E4414_RS19140	COG1196	nuclear chromosome segregation
E4414_RS19140	COG0739	heme binding
E4414_RS19190	COG0386	Belongs to the glutathione peroxidase family
E4414_RS19195	COG1846	Transcriptional regulator
E4414_RS19210	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
E4414_RS19235	COG0167	dihydroorotate dehydrogenase activity
E4414_RS19285	COG0649	NAD binding
E4414_RS19305	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
E4414_RS19305	COG2111	Na H antiporter
E4414_RS19335	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
E4414_RS19350	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4414_RS19385	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
E4414_RS19390	COG0840	transmembrane signaling receptor activity
E4414_RS19415	COG0492	ferredoxin-NADP+ reductase activity
E4414_RS19425	COG3290	protein histidine kinase activity
E4414_RS19425	COG0840	transmembrane signaling receptor activity
E4414_RS19450	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
E4414_RS19470	COG4608	Belongs to the ABC transporter superfamily
E4414_RS19475	COG0444	Belongs to the ABC transporter superfamily
E4414_RS19480	COG4239	(ABC) transporter, permease
E4414_RS19485	COG4174	ABC transporter (Permease)
E4414_RS19515	COG0175	sulfate reduction
E4414_RS19520	COG0175	sulfate reduction
E4414_RS19530	COG1648	precorrin-2 dehydrogenase activity
E4414_RS19530	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
E4414_RS19535	COG1648	precorrin-2 dehydrogenase activity
E4414_RS19535	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
E4414_RS19540	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E4414_RS19585	COG2304	oxidoreductase activity
E4414_RS19625	COG1231	oxidoreductase activity
E4414_RS19655	COG0187	DNA topoisomerase II activity
E4414_RS19700	COG1360	Flagellar Motor Protein
E4414_RS19725	COG0436	Aminotransferase
E4414_RS19750	COG5002	protein histidine kinase activity
E4414_RS19750	COG5001	Diguanylate cyclase
E4414_RS19750	COG3447	MASE1 domain protein
E4414_RS19755	COG2197	response regulator
E4414_RS19765	COG0473	3-isopropylmalate dehydrogenase activity
E4414_RS19860	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
E4414_RS19925	COG0183	Belongs to the thiolase family
E4414_RS19930	COG1250	3-hydroxyacyl-CoA dehydrogenase
E4414_RS19930	COG1024	Enoyl-CoA hydratase
E4414_RS19990	COG4943	cyclic-guanylate-specific phosphodiesterase activity
E4414_RS20055	COG0406	alpha-ribazole phosphatase activity
E4414_RS20185	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4414_RS20215	COG5398	heme oxygenase
E4414_RS20230	COG4771	TonB-dependent receptor
E4414_RS20265	COG1067	ATP-dependent peptidase activity
E4414_RS20270	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
E4414_RS20320	COG1694	Mazg nucleotide pyrophosphohydrolase
E4414_RS20325	COG0848	biopolymer transport protein
E4414_RS20360	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
E4414_RS20380	COG2433	Pfam Transposase IS66
E4414_RS20410	COG2200	EAL domain
E4414_RS20415	COG3706	GGDEF domain
E4414_RS20425	COG3706	GGDEF domain
E4414_RS20450	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E4414_RS20495	COG0427	acetyl-CoA hydrolase
E4414_RS20535	COG0385	Bile acid
E4414_RS20540	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E4414_RS20560	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
E4414_RS20565	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
E4414_RS20565	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
E4414_RS20570	COG1703	isobutyryl-CoA mutase activity
E4414_RS20605	COG0811	peptide transport
E4414_RS20625	COG0069	glutamate synthase activity
E4414_RS20645	COG3852	Histidine kinase
E4414_RS20650	COG1028	Short-chain dehydrogenase reductase Sdr
E4414_RS20775	COG5002	protein histidine kinase activity
E4414_RS20780	COG0741	lytic transglycosylase activity
E4414_RS20795	COG2885	chlorophyll binding
E4414_RS20815	COG0745	RESPONSE REGULATOR receiver
E4414_RS20825	COG2154	pterin-4-alpha-carbinolamine dehydratase
E4414_RS20915	COG1696	Membrane protein involved in D-alanine export
E4414_RS20950	COG1192	Involved in chromosome partitioning
E4414_RS20955	COG1475	DNA binding
E4414_RS20970	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
E4414_RS20975	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
E4414_RS20980	COG0561	phosphatase activity
E4414_RS20995	COG0181	hydroxymethylbilane synthase activity
E4414_RS21000	COG0113	porphobilinogen synthase activity
E4414_RS21010	COG5002	protein histidine kinase activity
E4414_RS21015	COG0745	RESPONSE REGULATOR receiver
E4414_RS21020	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
E4414_RS21025	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E4414_RS21050	COG1192	Involved in chromosome partitioning
E4414_RS21055	COG1475	DNA binding
E4414_RS21095	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
E4414_RS21100	COG1252	NADH dehydrogenase
E4414_RS21120	COG4221	oxidoreductase activity
E4414_RS21150	COG0714	Associated with various cellular activities
E4414_RS21185	COG0326	Molecular chaperone. Has ATPase activity
E4414_RS21260	COG1703	isobutyryl-CoA mutase activity
E4414_RS21265	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
E4414_RS21265	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
E4414_RS21340	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
E4414_RS21360	COG1022	Amp-dependent synthetase and ligase
E4414_RS21365	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
E4414_RS21405	COG0640	Transcriptional regulator
E4414_RS21420	COG0646	methionine synthase
E4414_RS21420	COG1410	methionine synthase
E4414_RS21440	COG2208	phosphoserine phosphatase activity
E4414_RS21440	COG2770	Histidine kinase
E4414_RS21450	COG1028	Short-chain dehydrogenase reductase Sdr
E4414_RS21460	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
E4414_RS21480	COG4221	oxidoreductase activity
E4414_RS21565	COG2801	Transposase and inactivated derivatives
E4414_RS21600	COG5464	transposase or invertase
E4414_RS21975	COG5464	transposase or invertase
E4414_RS22155	COG1475	DNA binding
E4414_RS22235	COG2801	Transposase and inactivated derivatives
E4414_RS22525	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
E4414_RS22535	COG2135	peptidase activity
E4414_RS22555	COG2801	Transposase and inactivated derivatives