locus-tag	class	description
E4413_RS00010	COG0592	DNA-directed DNA polymerase activity
E4413_RS00025	COG0187	DNA topoisomerase II activity
E4413_RS00065	COG2204	response regulator
E4413_RS00105	COG0009	L-threonylcarbamoyladenylate synthase
E4413_RS00155	COG0483	inositol monophosphate 1-phosphatase activity
E4413_RS00165	COG1874	Beta-galactosidase
E4413_RS00170	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
E4413_RS00175	COG0802	atpase or kinase
E4413_RS00185	COG0557	exoribonuclease II activity
E4413_RS00230	COG0840	transmembrane signaling receptor activity
E4413_RS00230	COG0840	transmembrane signaling receptor activity
E4413_RS00240	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4413_RS00245	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
E4413_RS00285	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
E4413_RS00290	COG1045	serine acetyltransferase
E4413_RS00310	COG0534	Mate efflux family protein
E4413_RS00315	COG1301	dicarboxylic acid transport
E4413_RS00335	COG2205	protein histidine kinase activity
E4413_RS00350	COG1024	Enoyl-CoA hydratase
E4413_RS00375	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E4413_RS00385	COG2226	methyltransferase
E4413_RS00500	COG1022	Amp-dependent synthetase and ligase
E4413_RS00520	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
E4413_RS00630	COG0351	phosphomethylpyrimidine kinase
E4413_RS00630	COG0352	thiamine-phosphate diphosphorylase activity
E4413_RS00650	COG3852	Histidine kinase
E4413_RS00655	COG1162	GTPase activity
E4413_RS00730	COG1132	(ABC) transporter
E4413_RS00735	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
E4413_RS00755	COG1034	ATP synthesis coupled electron transport
E4413_RS00770	COG1595	DNA-templated transcription, initiation
E4413_RS00785	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
E4413_RS00795	COG3977	Valine--pyruvate aminotransferase
E4413_RS00820	COG0594	ribonuclease P activity
E4413_RS00835	COG1847	R3H domain protein
E4413_RS00845	COG0280	phosphate acetyltransferase
E4413_RS00845	COG0281	malic enzyme
E4413_RS01030	COG0564	pseudouridine synthase activity
E4413_RS01060	COG0483	inositol monophosphate 1-phosphatase activity
E4413_RS01115	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
E4413_RS01125	COG1845	cytochrome c oxidase, subunit III
E4413_RS01150	COG4956	integral membrane protein (PIN domain superfamily)
E4413_RS01175	COG1192	Involved in chromosome partitioning
E4413_RS01200	COG0739	heme binding
E4413_RS01240	COG4591	ABC-type transport system involved in lipoprotein release permease component
E4413_RS01265	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E4413_RS01270	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
E4413_RS01285	COG3361	conserved protein (COG2071)
E4413_RS01340	COG0604	alcohol dehydrogenase
E4413_RS01355	COG1966	Carbon starvation protein
E4413_RS01400	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E4413_RS01410	COG0402	S-adenosylhomocysteine deaminase activity
E4413_RS01415	COG3942	CHAP domain
E4413_RS01430	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E4413_RS01495	COG0142	geranyltranstransferase activity
E4413_RS01500	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
E4413_RS01520	COG0720	synthase
E4413_RS01555	COG0584	glycerophosphoryl diester phosphodiesterase
E4413_RS01595	COG1815	bacterial-type flagellum-dependent cell motility
E4413_RS01620	COG2832	Protein of unknown function (DUF454)
E4413_RS01695	COG0698	ribose 5-phosphate isomerase
E4413_RS01730	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
E4413_RS01760	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
E4413_RS01785	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E4413_RS01800	COG0542	response to heat
E4413_RS01825	COG1366	Belongs to the anti-sigma-factor antagonist family
E4413_RS01860	COG1131	(ABC) transporter
E4413_RS01870	COG1639	'signal transduction protein
E4413_RS01875	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
E4413_RS01895	COG0180	Tryptophanyl-tRNA synthetase
E4413_RS01910	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
E4413_RS01915	COG2086	electron transfer activity
E4413_RS01925	COG1960	acyl-CoA dehydrogenase activity
E4413_RS01970	COG2326	polyphosphate kinase activity
E4413_RS02070	COG0488	(ABC) transporter
E4413_RS02080	COG1408	metallophosphoesterase
E4413_RS02100	COG0183	Belongs to the thiolase family
E4413_RS02205	COG0210	DNA helicase
E4413_RS02255	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
E4413_RS02270	COG0193	aminoacyl-tRNA hydrolase activity
E4413_RS02320	COG0347	Belongs to the P(II) protein family
E4413_RS02325	COG0004	ammonium transporteR
E4413_RS02330	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
E4413_RS02335	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
E4413_RS02345	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E4413_RS02375	COG1215	transferase activity, transferring glycosyl groups
E4413_RS02520	COG3876	Protein conserved in bacteria
E4413_RS02555	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
E4413_RS02580	COG0666	response to abiotic stimulus
E4413_RS02605	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
E4413_RS02625	COG4692	amylo-alpha-1,6-glucosidase activity
E4413_RS02650	COG0586	Pfam SNARE associated Golgi protein
E4413_RS02680	COG0288	reversible hydration of carbon dioxide
E4413_RS02725	COG1937	Protein conserved in bacteria
E4413_RS02735	COG2217	Heavy metal translocating P-type atpase
E4413_RS02755	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E4413_RS02770	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E4413_RS02775	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
E4413_RS02810	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
E4413_RS02850	COG0514	ATP-dependent DNA helicase (RecQ)
E4413_RS02915	COG0285	dihydrofolate synthase activity
E4413_RS02940	COG0463	Glycosyl transferase, family 2
E4413_RS02945	COG1639	'signal transduction protein
E4413_RS02955	COG0539	negative regulation of cytoplasmic translation
E4413_RS02985	COG1366	Belongs to the anti-sigma-factor antagonist family
E4413_RS03000	COG1482	cell wall glycoprotein biosynthetic process
E4413_RS03035	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E4413_RS03040	COG1858	cytochrome C peroxidase
E4413_RS03080	COG0731	radical SAM domain protein
E4413_RS03090	COG0840	transmembrane signaling receptor activity
E4413_RS03095	COG0840	transmembrane signaling receptor activity
E4413_RS03155	COG0527	aspartate kinase activity
E4413_RS03160	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E4413_RS03190	COG3552	Protein containing von Willebrand factor type A (VWA) domain
E4413_RS03195	COG2425	protein containing a von Willebrand factor type A (vWA) domain
E4413_RS03200	COG0714	Associated with various cellular activities
E4413_RS03210	COG4884	unkown
E4413_RS03210	COG3831	ATPase activity
E4413_RS03300	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
E4413_RS03315	COG1368	sulfuric ester hydrolase activity
E4413_RS03375	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E4413_RS03605	COG2314	TM2 domain
E4413_RS03625	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E4413_RS03645	COG0741	lytic transglycosylase activity
E4413_RS03695	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
E4413_RS03730	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4413_RS03735	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4413_RS03765	COG4585	Histidine kinase
E4413_RS03770	COG2197	response regulator
E4413_RS03795	COG0742	ribosomal rna small subunit methyltransferase
E4413_RS03825	COG0183	Belongs to the thiolase family
E4413_RS03975	COG1366	Belongs to the anti-sigma-factor antagonist family
E4413_RS03995	COG1639	'signal transduction protein
E4413_RS04025	COG1595	DNA-templated transcription, initiation
E4413_RS04055	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E4413_RS04095	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E4413_RS04105	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E4413_RS04120	COG1846	Transcriptional regulator
E4413_RS04180	COG0123	including yeast histone deacetylase and acetoin utilization protein
E4413_RS04190	COG1024	Enoyl-CoA hydratase
E4413_RS04220	COG2814	Major facilitator Superfamily
E4413_RS04230	COG2267	carboxylic ester hydrolase activity
E4413_RS04290	COG0195	Participates in both transcription termination and antitermination
E4413_RS04320	COG0612	Peptidase, M16
E4413_RS04330	COG0705	Rhomboid family
E4413_RS04350	COG1331	Highly conserved protein containing a thioredoxin domain
E4413_RS04370	COG0514	ATP-dependent DNA helicase (RecQ)
E4413_RS04375	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
E4413_RS04380	COG1074	ATP-dependent DNA helicase activity
E4413_RS04385	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E4413_RS04390	COG1131	(ABC) transporter
E4413_RS04395	COG0842	Transport permease protein
E4413_RS04455	COG4884	unkown
E4413_RS04455	COG3831	ATPase activity
E4413_RS04460	COG3831	ATPase activity
E4413_RS04460	COG4884	unkown
E4413_RS04535	COG1487	ribonuclease activity
E4413_RS04560	COG2815	serine threonine protein kinase
E4413_RS04560	COG0515	serine threonine protein kinase
E4413_RS04565	COG4974	Belongs to the 'phage' integrase family
E4413_RS04585	COG0848	biopolymer transport protein
E4413_RS04595	COG0811	peptide transport
E4413_RS04690	COG3959	Transketolase, thiamine diphosphate binding domain
E4413_RS04705	COG0142	geranyltranstransferase activity
E4413_RS04840	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
E4413_RS04845	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
E4413_RS04865	COG1857	crispr-associated protein
E4413_RS04875	COG1203	CRISPR-associated helicase, Cas3
E4413_RS04935	COG0488	(ABC) transporter
E4413_RS04940	COG0656	L-ascorbic acid biosynthetic process
E4413_RS04950	COG1408	metallophosphoesterase
E4413_RS05005	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E4413_RS05050	COG2267	carboxylic ester hydrolase activity
E4413_RS05065	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E4413_RS05115	COG0183	Belongs to the thiolase family
E4413_RS05160	COG1262	PFAM Formylglycine-generating sulfatase enzyme
E4413_RS05185	COG0515	serine threonine protein kinase
E4413_RS05185	COG2815	serine threonine protein kinase
E4413_RS05210	COG2205	protein histidine kinase activity
E4413_RS05215	COG0745	RESPONSE REGULATOR receiver
E4413_RS05270	COG1652	LysM domain
E4413_RS05275	COG1366	Belongs to the anti-sigma-factor antagonist family
E4413_RS05325	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E4413_RS05340	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
E4413_RS05365	COG4932	domain protein
E4413_RS05365	COG5492	domain, Protein
E4413_RS05385	COG0463	Glycosyl transferase, family 2
E4413_RS05440	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4413_RS05445	COG0436	Aminotransferase
E4413_RS05510	COG3831	ATPase activity
E4413_RS05510	COG4884	unkown
E4413_RS05560	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
E4413_RS05565	COG1704	LemA family
E4413_RS05610	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
E4413_RS05610	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
E4413_RS05655	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
E4413_RS05655	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E4413_RS05685	COG1136	(ABC) transporter
E4413_RS05690	COG2385	sporulation resulting in formation of a cellular spore
E4413_RS05720	COG1858	cytochrome C peroxidase
E4413_RS05745	COG1215	transferase activity, transferring glycosyl groups
E4413_RS05760	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
E4413_RS05780	COG1988	membrane-bound metal-dependent
E4413_RS05790	COG0596	Alpha beta hydrolase
E4413_RS05800	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
E4413_RS05800	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
E4413_RS05800	COG1703	isobutyryl-CoA mutase activity
E4413_RS05805	COG0204	Acyl-transferase
E4413_RS05815	COG0671	phosphoesterase, PA-phosphatase related
E4413_RS05830	COG4565	transcriptional regulatory protein
E4413_RS05870	COG3011	Protein conserved in bacteria
E4413_RS05900	COG0038	chloride channel
E4413_RS05905	COG3706	GGDEF domain
E4413_RS05930	COG3706	GGDEF domain
E4413_RS05945	COG0469	pyruvate kinase activity
E4413_RS05950	COG0123	including yeast histone deacetylase and acetoin utilization protein
E4413_RS05975	COG3345	alpha-galactosidase
E4413_RS05980	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
E4413_RS05985	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
E4413_RS06025	COG0739	heme binding
E4413_RS06045	COG1396	sequence-specific DNA binding
E4413_RS06075	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E4413_RS06095	COG2226	methyltransferase
E4413_RS06135	COG0850	regulation of cytokinetic process
E4413_RS06185	COG1054	Belongs to the UPF0176 family
E4413_RS06205	COG0596	Alpha beta hydrolase
E4413_RS06225	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
E4413_RS06235	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
E4413_RS06290	COG4251	negative regulation of phosphorylation
E4413_RS06295	COG0784	Response regulator, receiver
E4413_RS06300	COG0784	Response regulator, receiver
E4413_RS06300	COG4191	Histidine kinase
E4413_RS06385	COG0450	alkyl hydroperoxide reductase
E4413_RS06390	COG0719	Fe-S assembly protein
E4413_RS06435	COG0598	Magnesium transport protein CorA
E4413_RS06450	COG1309	transcriptional regulator
E4413_RS06480	COG0356	it plays a direct role in the translocation of protons across the membrane
E4413_RS06485	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
E4413_RS06610	COG0768	penicillin binding
E4413_RS06615	COG0772	Belongs to the SEDS family
E4413_RS06645	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
E4413_RS06690	COG0439	Biotin carboxylase
E4413_RS06695	COG0511	ligase activity, forming carbon-carbon bonds
E4413_RS06705	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
E4413_RS06740	COG1959	2 iron, 2 sulfur cluster binding
E4413_RS06750	COG2070	2-Nitropropane dioxygenase
E4413_RS06805	COG0247	lactate metabolic process
E4413_RS06805	COG2181	nitrate reductase activity
E4413_RS06825	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
E4413_RS06860	COG1181	Belongs to the D-alanine--D-alanine ligase family
E4413_RS06875	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
E4413_RS06880	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
E4413_RS06880	COG0116	Belongs to the methyltransferase superfamily
E4413_RS06890	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E4413_RS06895	COG0859	PFAM glycosyl transferase family 9
E4413_RS06900	COG0006	proline dipeptidase activity
E4413_RS06925	COG1473	amidohydrolase
E4413_RS06960	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
E4413_RS06975	COG1959	2 iron, 2 sulfur cluster binding
E4413_RS06975	COG1295	ribonuclease BN
E4413_RS06980	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E4413_RS07060	COG4774	siderophore transport
E4413_RS07070	COG1960	acyl-CoA dehydrogenase activity
E4413_RS07095	COG3958	Transketolase
E4413_RS07105	COG1063	alcohol dehydrogenase
E4413_RS07115	COG2030	dehydratase
E4413_RS07130	COG0339	signal peptide processing
E4413_RS07140	COG0625	glutathione transferase activity
E4413_RS07145	COG1028	Short-chain dehydrogenase reductase Sdr
E4413_RS07160	COG0688	phosphatidylethanolamine metabolic process
E4413_RS07170	COG1776	CheC inhibitor of MCP methylation
E4413_RS07170	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E4413_RS07180	COG1338	Plays a role in the flagellum-specific transport system
E4413_RS07185	COG1987	bacterial-type flagellum assembly
E4413_RS07195	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E4413_RS07205	COG1419	protein localization to endoplasmic reticulum
E4413_RS07220	COG1191	sigma factor activity
E4413_RS07245	COG0194	GDP metabolic process
E4413_RS07275	COG1766	The M ring may be actively involved in energy transduction
E4413_RS07285	COG1317	bacterial-type flagellum organization
E4413_RS07315	COG2089	acid synthase
E4413_RS07360	COG0028	Belongs to the TPP enzyme family
E4413_RS07365	COG0440	acetolactate synthase activity
E4413_RS07375	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E4413_RS07380	COG1472	Belongs to the glycosyl hydrolase 3 family
E4413_RS07385	COG2755	lipolytic protein G-D-S-L family
E4413_RS07430	COG0724	RNA recognition motif
E4413_RS07450	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
E4413_RS07490	COG0488	(ABC) transporter
E4413_RS07530	COG4251	negative regulation of phosphorylation
E4413_RS07535	COG4565	transcriptional regulatory protein
E4413_RS07560	COG3706	GGDEF domain
E4413_RS07560	COG2203	Gaf domain
E4413_RS07560	COG4251	negative regulation of phosphorylation
E4413_RS07560	COG5001	Diguanylate cyclase
E4413_RS07565	COG2379	hydroxypyruvate reductase
E4413_RS07600	COG0708	Exodeoxyribonuclease III
E4413_RS07690	COG0492	ferredoxin-NADP+ reductase activity
E4413_RS07800	COG4555	ABC transporter
E4413_RS07810	COG2226	methyltransferase
E4413_RS07825	COG0024	Methionine aminopeptidase
E4413_RS07840	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
E4413_RS07910	COG2208	phosphoserine phosphatase activity
E4413_RS07915	COG1366	Belongs to the anti-sigma-factor antagonist family
E4413_RS07920	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
E4413_RS07925	COG0439	Biotin carboxylase
E4413_RS07955	COG0840	transmembrane signaling receptor activity
E4413_RS07955	COG3290	protein histidine kinase activity
E4413_RS07960	COG0643	Histidine kinase
E4413_RS07960	COG2198	Histidine kinase
E4413_RS07970	COG0745	RESPONSE REGULATOR receiver
E4413_RS07975	COG2201	protein-glutamate methylesterase activity
E4413_RS07980	COG2205	protein histidine kinase activity
E4413_RS08015	COG2096	Adenosyltransferase
E4413_RS08020	COG3104	oligopeptide transport
E4413_RS08025	COG0791	NLP P60 protein
E4413_RS08035	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
E4413_RS08035	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
E4413_RS08040	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
E4413_RS08040	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
E4413_RS08070	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
E4413_RS08085	COG5000	phosphorelay sensor kinase activity
E4413_RS08090	COG2204	response regulator
E4413_RS08100	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
E4413_RS08110	COG2815	serine threonine protein kinase
E4413_RS08110	COG0515	serine threonine protein kinase
E4413_RS08145	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
E4413_RS08185	COG0739	heme binding
E4413_RS08200	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
E4413_RS08205	COG1459	type II secretion system
E4413_RS08310	COG1193	negative regulation of DNA recombination
E4413_RS08375	COG0489	protein tyrosine kinase activity
E4413_RS08385	COG0163	prenyltransferase activity
E4413_RS08390	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
E4413_RS08410	COG0012	GTP binding
E4413_RS08420	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
E4413_RS08425	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4413_RS08430	COG0640	Transcriptional regulator
E4413_RS08435	COG1028	Short-chain dehydrogenase reductase Sdr
E4413_RS08440	COG1639	'signal transduction protein
E4413_RS08450	COG0497	DNA recombination
E4413_RS08455	COG0811	peptide transport
E4413_RS08460	COG0848	biopolymer transport protein
E4413_RS08465	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E4413_RS08480	COG1218	3'(2'),5'-bisphosphate nucleotidase
E4413_RS08495	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E4413_RS08500	COG1022	Amp-dependent synthetase and ligase
E4413_RS08510	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E4413_RS08520	COG4221	oxidoreductase activity
E4413_RS08545	COG4335	DNA alkylation repair
E4413_RS08595	COG1187	pseudouridine synthase activity
E4413_RS08635	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
E4413_RS08640	COG1516	flagellar protein fliS
E4413_RS08665	COG0586	Pfam SNARE associated Golgi protein
E4413_RS08685	COG1104	cysteine desulfurase activity
E4413_RS08705	COG1024	Enoyl-CoA hydratase
E4413_RS08715	COG0277	FAD linked oxidase domain protein
E4413_RS08720	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
E4413_RS08775	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
E4413_RS08955	COG0840	transmembrane signaling receptor activity
E4413_RS08970	COG4771	TonB-dependent receptor
E4413_RS08985	COG0726	polysaccharide deacetylase
E4413_RS08995	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
E4413_RS09010	COG0358	DNA primase activity
E4413_RS09070	COG2239	Acts as a magnesium transporter
E4413_RS09075	COG1360	Flagellar Motor Protein
E4413_RS09095	COG0616	signal peptide processing
E4413_RS09110	COG0009	L-threonylcarbamoyladenylate synthase
E4413_RS09160	COG0446	pyridine nucleotide-disulphide oxidoreductase
E4413_RS09160	COG1902	pentaerythritol trinitrate reductase activity
E4413_RS09200	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
E4413_RS09210	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E4413_RS09215	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E4413_RS09230	COG0312	modulator of DNA gyrase
E4413_RS09260	COG1022	Amp-dependent synthetase and ligase
E4413_RS09295	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E4413_RS09315	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
E4413_RS09325	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
E4413_RS09360	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E4413_RS09400	COG0560	Phosphoserine phosphatase
E4413_RS09420	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
E4413_RS09430	COG0156	8-amino-7-oxononanoate synthase activity
E4413_RS09440	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
E4413_RS09440	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E4413_RS09460	COG0083	homoserine kinase activity
E4413_RS09470	COG2267	carboxylic ester hydrolase activity
E4413_RS09480	COG0436	Aminotransferase
E4413_RS09495	COG0616	signal peptide processing
E4413_RS09530	COG1234	tRNA 3'-trailer cleavage
E4413_RS09550	COG1131	(ABC) transporter
E4413_RS09555	COG0842	Transport permease protein
E4413_RS09575	COG0271	Belongs to the BolA IbaG family
E4413_RS09580	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
E4413_RS09600	COG0405	Gamma-glutamyltransferase
E4413_RS09605	COG0542	response to heat
E4413_RS09620	COG1595	DNA-templated transcription, initiation
E4413_RS09635	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E4413_RS09640	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
E4413_RS09665	COG0444	Belongs to the ABC transporter superfamily
E4413_RS09680	COG0463	Glycosyl transferase, family 2
E4413_RS09735	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E4413_RS09750	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
E4413_RS09770	COG0330	HflC and HflK could
E4413_RS09775	COG0330	HflC and HflK could
E4413_RS09785	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E4413_RS09820	COG2813	Specifically methylates the guanine in position
E4413_RS09820	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E4413_RS09835	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
E4413_RS09840	COG1127	ABC transporter
E4413_RS09855	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
E4413_RS09870	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
E4413_RS09880	COG0772	Belongs to the SEDS family
E4413_RS09980	COG3876	Protein conserved in bacteria
E4413_RS10020	COG4452	Inner membrane protein CreD
E4413_RS10030	COG2205	protein histidine kinase activity
E4413_RS10035	COG0745	RESPONSE REGULATOR receiver
E4413_RS10040	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
E4413_RS10045	COG0508	dehydrogenase complex catalyzes the overall conversion of
E4413_RS10045	COG0022	dehydrogenase e1 component
E4413_RS10050	COG0508	dehydrogenase complex catalyzes the overall conversion of
E4413_RS10055	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E4413_RS10100	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E4413_RS10120	COG1649	PFAM Uncharacterised BCR, COG1649
E4413_RS10120	COG0726	polysaccharide deacetylase
E4413_RS10140	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
E4413_RS10145	COG0352	thiamine-phosphate diphosphorylase activity
E4413_RS10155	COG1385	rRNA (uridine-N3-)-methyltransferase activity
E4413_RS10175	COG2200	EAL domain
E4413_RS10180	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
E4413_RS10215	COG1028	Short-chain dehydrogenase reductase Sdr
E4413_RS10290	COG0519	Catalyzes the synthesis of GMP from XMP
E4413_RS10295	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E4413_RS10440	COG1960	acyl-CoA dehydrogenase activity
E4413_RS10450	COG3118	belongs to the thioredoxin family
E4413_RS10465	COG0805	protein transport
E4413_RS10480	COG0724	RNA recognition motif
E4413_RS10500	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
E4413_RS10515	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E4413_RS10550	COG2267	carboxylic ester hydrolase activity
E4413_RS10570	COG1053	succinate dehydrogenase
E4413_RS10720	COG0733	neurotransmitter:sodium symporter activity
E4413_RS10725	COG1199	ATP-dependent helicase activity
E4413_RS10780	COG3458	cephalosporin-C deacetylase activity
E4413_RS10790	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E4413_RS10800	COG4191	Histidine kinase
E4413_RS10815	COG0735	belongs to the Fur family
E4413_RS10825	COG4786	Flagellar basal body rod
E4413_RS10840	COG2205	protein histidine kinase activity
E4413_RS10855	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
E4413_RS10890	COG0728	peptidoglycan biosynthetic process
E4413_RS10935	COG1639	'signal transduction protein
E4413_RS10940	COG1119	ATPase activity
E4413_RS10950	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E4413_RS10970	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
E4413_RS10985	COG4251	negative regulation of phosphorylation
E4413_RS11000	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E4413_RS11035	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4413_RS11035	COG4191	Histidine kinase
E4413_RS11075	COG1381	Involved in DNA repair and RecF pathway recombination
E4413_RS11085	COG1480	7TM receptor with intracellular HD hydrolase
E4413_RS11090	COG1702	phosphate starvation-inducible protein PhoH
E4413_RS11100	COG0305	Participates in initiation and elongation during chromosome replication
E4413_RS11115	COG0629	single-stranded DNA binding
E4413_RS11145	COG0471	metal ion transport
E4413_RS11170	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
E4413_RS11175	COG1088	dTDP-glucose 4,6-dehydratase activity
E4413_RS11195	COG0463	Glycosyl transferase, family 2
E4413_RS11195	COG1216	Glycosyl transferase, family 2
E4413_RS11215	COG1442	glycosyl transferase family 8
E4413_RS11240	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
E4413_RS11265	COG0438	transferase activity, transferring glycosyl groups
E4413_RS11285	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E4413_RS11300	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
E4413_RS11310	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
E4413_RS11315	COG1028	Short-chain dehydrogenase reductase Sdr
E4413_RS11335	COG1028	Short-chain dehydrogenase reductase Sdr
E4413_RS11340	COG3836	Belongs to the HpcH HpaI aldolase family
E4413_RS11350	COG0517	IMP dehydrogenase activity
E4413_RS11350	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
E4413_RS11355	COG2877	3-deoxy-8-phosphooctulonate synthase activity
E4413_RS11370	COG2089	acid synthase
E4413_RS11380	COG3980	spore coat polysaccharide biosynthesis protein
E4413_RS11390	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
E4413_RS11410	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E4413_RS11420	COG1132	(ABC) transporter
E4413_RS11435	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
E4413_RS11440	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E4413_RS11455	COG2813	Specifically methylates the guanine in position
E4413_RS11460	COG0494	nUDIX hydrolase
E4413_RS11475	COG3958	Transketolase
E4413_RS11480	COG3959	Transketolase, thiamine diphosphate binding domain
E4413_RS11500	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4413_RS11505	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
E4413_RS11505	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
E4413_RS11510	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
E4413_RS11520	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
E4413_RS11530	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4413_RS11555	COG0071	Belongs to the small heat shock protein (HSP20) family
E4413_RS11570	COG1999	signal sequence binding
E4413_RS11610	COG0475	glutathione-regulated potassium exporter activity
E4413_RS11635	COG1073	alpha beta
E4413_RS11675	COG1830	Aldolase
E4413_RS11690	COG5002	protein histidine kinase activity
E4413_RS11765	COG0793	Belongs to the peptidase S41A family
E4413_RS11770	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
E4413_RS11860	COG1757	Na H antiporter
E4413_RS11865	COG0564	pseudouridine synthase activity
E4413_RS11875	COG1304	FMN binding
E4413_RS11910	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
E4413_RS11985	COG0366	Alpha amylase catalytic
E4413_RS11995	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
E4413_RS12000	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
E4413_RS12020	COG2003	Belongs to the UPF0758 family
E4413_RS12055	COG0793	Belongs to the peptidase S41A family
E4413_RS12120	COG1136	(ABC) transporter
E4413_RS12120	COG0577	efflux transmembrane transporter activity
E4413_RS12130	COG0537	adenosine 5'-monophosphoramidase activity
E4413_RS12175	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E4413_RS12185	COG0631	protein serine/threonine phosphatase activity
E4413_RS12190	COG1028	Short-chain dehydrogenase reductase Sdr
E4413_RS12200	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
E4413_RS12250	COG0095	Lipoate-protein ligase
E4413_RS12305	COG2409	Drug exporters of the RND superfamily
E4413_RS12305	COG1033	growth of symbiont in host cell
E4413_RS12320	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4413_RS12330	COG2339	peptidase activity
E4413_RS12360	COG2755	lipolytic protein G-D-S-L family
E4413_RS12360	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
E4413_RS12370	COG1217	gtp-binding protein TYPA
E4413_RS12385	COG1741	Belongs to the pirin family
E4413_RS12460	COG4771	TonB-dependent receptor
E4413_RS12475	COG2843	Capsule synthesis protein
E4413_RS12490	COG4251	negative regulation of phosphorylation
E4413_RS12495	COG0784	Response regulator, receiver
E4413_RS12515	COG0385	Bile acid
E4413_RS12525	COG0697	spore germination
E4413_RS12530	COG0628	permease
E4413_RS12545	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
E4413_RS12550	COG0673	inositol 2-dehydrogenase activity
E4413_RS12560	COG0154	amidase activity
E4413_RS12630	COG0174	glutamine synthetase
E4413_RS12710	COG3831	ATPase activity
E4413_RS12710	COG4884	unkown
E4413_RS12720	COG0714	Associated with various cellular activities
E4413_RS12725	COG0436	Aminotransferase
E4413_RS12765	COG0577	efflux transmembrane transporter activity
E4413_RS12765	COG1136	(ABC) transporter
E4413_RS12785	COG1368	sulfuric ester hydrolase activity
E4413_RS12860	COG2183	response to ionizing radiation
E4413_RS12860	COG0539	negative regulation of cytoplasmic translation
E4413_RS12875	COG0287	Prephenate dehydrogenase
E4413_RS12880	COG1605	Chorismate mutase
E4413_RS12880	COG0077	Prephenate dehydratase
E4413_RS12885	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
E4413_RS12895	COG2201	protein-glutamate methylesterase activity
E4413_RS12905	COG2198	Histidine kinase
E4413_RS12905	COG0643	Histidine kinase
E4413_RS12915	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
E4413_RS12920	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
E4413_RS13010	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E4413_RS13065	COG0861	Integral membrane protein TerC family
E4413_RS13110	COG1024	Enoyl-CoA hydratase
E4413_RS13145	COG0840	transmembrane signaling receptor activity
E4413_RS13155	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
E4413_RS13180	COG5001	Diguanylate cyclase
E4413_RS13245	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
E4413_RS13250	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E4413_RS13275	COG0515	serine threonine protein kinase
E4413_RS13305	COG4208	sulfate ABC transporter
E4413_RS13315	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
E4413_RS13325	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
E4413_RS13325	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
E4413_RS13355	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E4413_RS13360	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E4413_RS13370	COG1862	Preprotein translocase
E4413_RS13420	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
E4413_RS13445	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E4413_RS13550	COG0484	heat shock protein binding
E4413_RS13565	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
E4413_RS13590	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E4413_RS13610	COG0640	Transcriptional regulator
E4413_RS13810	COG1388	LysM domain
E4413_RS13810	COG4942	peptidase
E4413_RS13855	COG1024	Enoyl-CoA hydratase
E4413_RS13895	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
E4413_RS13930	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
E4413_RS13940	COG0386	Belongs to the glutathione peroxidase family
E4413_RS13950	COG4772	TonB-dependent receptor
E4413_RS13985	COG0243	molybdopterin cofactor binding
E4413_RS14040	COG1262	PFAM Formylglycine-generating sulfatase enzyme
E4413_RS14095	COG0750	zinc metalloprotease
E4413_RS14095	COG0750	zinc metalloprotease
E4413_RS14105	COG0575	Belongs to the CDS family
E4413_RS14160	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
E4413_RS14175	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E4413_RS14225	COG4772	TonB-dependent receptor
E4413_RS14355	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
E4413_RS14375	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
E4413_RS14380	COG1138	Cytochrome C-type biogenesis protein
E4413_RS14410	COG0625	glutathione transferase activity
E4413_RS14600	COG0612	Peptidase, M16
E4413_RS14605	COG0612	Peptidase, M16
E4413_RS14640	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
E4413_RS14720	COG0250	Participates in transcription elongation, termination and antitermination
E4413_RS14725	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E4413_RS14770	COG0860	N-Acetylmuramoyl-L-alanine amidase
E4413_RS14775	COG0513	Belongs to the DEAD box helicase family
E4413_RS14780	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E4413_RS14810	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
E4413_RS14830	COG0196	riboflavin kinase activity
E4413_RS14855	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
E4413_RS14860	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
E4413_RS14865	COG0739	heme binding
E4413_RS14875	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
E4413_RS14880	COG0277	FAD linked oxidase domain protein
E4413_RS14885	COG3153	acetyltransferase
E4413_RS14885	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E4413_RS14900	COG4772	TonB-dependent receptor
E4413_RS14985	COG1028	Short-chain dehydrogenase reductase Sdr
E4413_RS15050	COG0840	transmembrane signaling receptor activity
E4413_RS15065	COG1858	cytochrome C peroxidase
E4413_RS15075	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
E4413_RS15100	COG1116	anion transmembrane transporter activity
E4413_RS15125	COG4608	Belongs to the ABC transporter superfamily
E4413_RS15145	COG1715	Restriction endonuclease
E4413_RS15200	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
E4413_RS15205	COG0477	Major facilitator Superfamily
E4413_RS15230	COG2226	methyltransferase
E4413_RS15260	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E4413_RS15290	COG4943	cyclic-guanylate-specific phosphodiesterase activity
E4413_RS15330	COG0822	iron-sulfur transferase activity
E4413_RS15335	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E4413_RS15340	COG2146	nitrite reductase [NAD(P)H] activity
E4413_RS15345	COG0719	Fe-S assembly protein
E4413_RS15350	COG0396	ATPase activity
E4413_RS15365	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
E4413_RS15380	COG1366	Belongs to the anti-sigma-factor antagonist family
E4413_RS15395	COG1360	Flagellar Motor Protein
E4413_RS15405	COG1582	Flagellar protein (FlbD)
E4413_RS15420	COG3384	dioxygenase
E4413_RS15435	COG0758	DNA mediated transformation
E4413_RS15455	COG0456	acetyltransferase
E4413_RS15500	COG0783	Belongs to the Dps family
E4413_RS15515	COG3119	arylsulfatase activity
E4413_RS15525	COG2030	dehydratase
E4413_RS15575	COG1324	tolerance protein
E4413_RS15590	COG0004	ammonium transporteR
E4413_RS15595	COG0121	glutamine amidotransferase
E4413_RS15605	COG0438	transferase activity, transferring glycosyl groups
E4413_RS15610	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E4413_RS15610	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E4413_RS15625	COG1960	acyl-CoA dehydrogenase activity
E4413_RS15635	COG0512	Glutamine amidotransferase of anthranilate synthase
E4413_RS15635	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
E4413_RS15640	COG1132	(ABC) transporter
E4413_RS15690	COG0460	homoserine dehydrogenase
E4413_RS15725	COG1999	signal sequence binding
E4413_RS15760	COG2205	protein histidine kinase activity
E4413_RS15760	COG0784	Response regulator, receiver
E4413_RS15785	COG0596	Alpha beta hydrolase
E4413_RS15810	COG1573	uracil-dna glycosylase
E4413_RS15835	COG1960	acyl-CoA dehydrogenase activity
E4413_RS15860	COG0488	(ABC) transporter
E4413_RS15865	COG2885	chlorophyll binding
E4413_RS15890	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
E4413_RS15895	COG4166	transmembrane transport
E4413_RS15900	COG1132	(ABC) transporter
E4413_RS15905	COG1663	tetraacyldisaccharide 4'-kinase activity
E4413_RS15930	COG0768	penicillin binding
E4413_RS15960	COG0673	inositol 2-dehydrogenase activity
E4413_RS15965	COG1678	Uncharacterized ACR, COG1678
E4413_RS15980	COG4181	ATPase activity
E4413_RS16155	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E4413_RS16180	COG1639	'signal transduction protein
E4413_RS16240	COG0724	RNA recognition motif
E4413_RS16300	COG4932	domain protein
E4413_RS16300	COG5492	domain, Protein
E4413_RS16305	COG4932	domain protein
E4413_RS16305	COG5492	domain, Protein
E4413_RS16325	COG0346	lactoylglutathione lyase activity
E4413_RS16350	COG0531	amino acid
E4413_RS16360	COG1846	Transcriptional regulator
E4413_RS16370	COG2259	Doxx family
E4413_RS16385	COG2081	HI0933 family
E4413_RS16425	COG1040	competence protein
E4413_RS16435	COG3239	Fatty acid desaturase
E4413_RS16485	COG0519	Catalyzes the synthesis of GMP from XMP
E4413_RS16505	COG1881	PFAM PEBP family protein
E4413_RS16515	COG1309	transcriptional regulator
E4413_RS16570	COG2205	protein histidine kinase activity
E4413_RS16570	COG0784	Response regulator, receiver
E4413_RS16600	COG4585	Histidine kinase
E4413_RS16605	COG2197	response regulator
E4413_RS16665	COG1090	epimerase
E4413_RS16685	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
E4413_RS16710	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
E4413_RS16720	COG4191	Histidine kinase
E4413_RS16725	COG5002	protein histidine kinase activity
E4413_RS16735	COG0596	Alpha beta hydrolase
E4413_RS16740	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E4413_RS16760	COG4943	cyclic-guanylate-specific phosphodiesterase activity
E4413_RS16770	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
E4413_RS16820	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
E4413_RS16835	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4413_RS16850	COG1960	acyl-CoA dehydrogenase activity
E4413_RS16875	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
E4413_RS16880	COG1253	flavin adenine dinucleotide binding
E4413_RS16915	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
E4413_RS16930	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E4413_RS16935	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E4413_RS16955	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
E4413_RS16955	COG1605	Chorismate mutase
E4413_RS16965	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
E4413_RS16965	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
E4413_RS16970	COG1484	DNA-dependent DNA replication
E4413_RS16985	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
E4413_RS16990	COG0534	Mate efflux family protein
E4413_RS17010	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E4413_RS17020	COG0667	Aldo Keto reductase
E4413_RS17040	COG0494	nUDIX hydrolase
E4413_RS17050	COG0584	glycerophosphoryl diester phosphodiesterase
E4413_RS17075	COG3263	regulation of cellular component size
E4413_RS17090	COG0456	acetyltransferase
E4413_RS17100	COG1032	radical SAM domain protein
E4413_RS17105	COG2205	protein histidine kinase activity
E4413_RS17105	COG2198	Histidine kinase
E4413_RS17105	COG0784	Response regulator, receiver
E4413_RS17190	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E4413_RS17195	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E4413_RS17255	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
E4413_RS17265	COG1560	Kdo2-lipid A biosynthetic process
E4413_RS17275	COG2271	Major facilitator Superfamily
E4413_RS17300	COG0513	Belongs to the DEAD box helicase family
E4413_RS17305	COG1262	PFAM Formylglycine-generating sulfatase enzyme
E4413_RS17310	COG4221	oxidoreductase activity
E4413_RS17355	COG3956	TIGRFAM MazG family protein
E4413_RS17365	COG0745	RESPONSE REGULATOR receiver
E4413_RS17375	COG0538	isocitrate dehydrogenase activity
E4413_RS17415	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
E4413_RS17480	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
E4413_RS17485	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
E4413_RS17490	COG0494	nUDIX hydrolase
E4413_RS17530	COG0745	RESPONSE REGULATOR receiver
E4413_RS17535	COG5002	protein histidine kinase activity
E4413_RS17585	COG2030	dehydratase
E4413_RS17590	COG1960	acyl-CoA dehydrogenase activity
E4413_RS17600	COG4942	peptidase
E4413_RS17610	COG1595	DNA-templated transcription, initiation
E4413_RS17620	COG2949	membrane
E4413_RS17700	COG1250	3-hydroxyacyl-CoA dehydrogenase
E4413_RS17700	COG1024	Enoyl-CoA hydratase
E4413_RS17705	COG0183	Belongs to the thiolase family
E4413_RS17755	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
E4413_RS17840	COG0473	3-isopropylmalate dehydrogenase activity
E4413_RS17850	COG2197	response regulator
E4413_RS17855	COG3447	MASE1 domain protein
E4413_RS17855	COG5002	protein histidine kinase activity
E4413_RS17855	COG5001	Diguanylate cyclase
E4413_RS17880	COG0436	Aminotransferase
E4413_RS17895	COG1360	Flagellar Motor Protein
E4413_RS17940	COG0187	DNA topoisomerase II activity
E4413_RS17960	COG1231	oxidoreductase activity
E4413_RS17995	COG2304	oxidoreductase activity
E4413_RS18035	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E4413_RS18040	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
E4413_RS18040	COG1648	precorrin-2 dehydrogenase activity
E4413_RS18045	COG1648	precorrin-2 dehydrogenase activity
E4413_RS18045	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
E4413_RS18055	COG0175	sulfate reduction
E4413_RS18060	COG0175	sulfate reduction
E4413_RS18095	COG4174	ABC transporter (Permease)
E4413_RS18100	COG4239	(ABC) transporter, permease
E4413_RS18105	COG0444	Belongs to the ABC transporter superfamily
E4413_RS18110	COG4608	Belongs to the ABC transporter superfamily
E4413_RS18130	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
E4413_RS18165	COG0840	transmembrane signaling receptor activity
E4413_RS18165	COG3290	protein histidine kinase activity
E4413_RS18175	COG0492	ferredoxin-NADP+ reductase activity
E4413_RS18200	COG0840	transmembrane signaling receptor activity
E4413_RS18205	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
E4413_RS18240	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4413_RS18255	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
E4413_RS18285	COG2111	Na H antiporter
E4413_RS18285	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
E4413_RS18305	COG0649	NAD binding
E4413_RS18355	COG0167	dihydroorotate dehydrogenase activity
E4413_RS18385	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
E4413_RS18410	COG1846	Transcriptional regulator
E4413_RS18415	COG0386	Belongs to the glutathione peroxidase family
E4413_RS18465	COG0739	heme binding
E4413_RS18465	COG0741	lytic transglycosylase activity
E4413_RS18465	COG1196	nuclear chromosome segregation
E4413_RS18505	COG2363	Small membrane protein
E4413_RS18515	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
E4413_RS18545	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
E4413_RS18565	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
E4413_RS18585	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
E4413_RS18600	COG0084	hydrolase, TatD family'
E4413_RS18655	COG1475	DNA binding
E4413_RS18660	COG1192	Involved in chromosome partitioning
E4413_RS18670	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E4413_RS18690	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
E4413_RS18705	COG4771	TonB-dependent receptor
E4413_RS18720	COG5398	heme oxygenase
E4413_RS18750	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4413_RS18885	COG0406	alpha-ribazole phosphatase activity
E4413_RS18950	COG4943	cyclic-guanylate-specific phosphodiesterase activity
E4413_RS19000	COG4221	oxidoreductase activity
E4413_RS19025	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
E4413_RS19035	COG1028	Short-chain dehydrogenase reductase Sdr
E4413_RS19045	COG2208	phosphoserine phosphatase activity
E4413_RS19045	COG2770	Histidine kinase
E4413_RS19065	COG0646	methionine synthase
E4413_RS19065	COG1410	methionine synthase
E4413_RS19080	COG2226	methyltransferase
E4413_RS19120	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
E4413_RS19125	COG1022	Amp-dependent synthetase and ligase
E4413_RS19145	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
E4413_RS19215	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
E4413_RS19215	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
E4413_RS19220	COG1703	isobutyryl-CoA mutase activity
E4413_RS19295	COG0326	Molecular chaperone. Has ATPase activity
E4413_RS19330	COG0714	Associated with various cellular activities
E4413_RS19360	COG4221	oxidoreductase activity
E4413_RS19380	COG1252	NADH dehydrogenase
E4413_RS19385	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
E4413_RS19425	COG1475	DNA binding
E4413_RS19430	COG1192	Involved in chromosome partitioning
E4413_RS19455	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E4413_RS19460	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
E4413_RS19465	COG0745	RESPONSE REGULATOR receiver
E4413_RS19470	COG5002	protein histidine kinase activity
E4413_RS19480	COG0113	porphobilinogen synthase activity
E4413_RS19485	COG0181	hydroxymethylbilane synthase activity
E4413_RS19500	COG0561	phosphatase activity
E4413_RS19505	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
E4413_RS19510	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
E4413_RS19525	COG1475	DNA binding
E4413_RS19530	COG1192	Involved in chromosome partitioning
E4413_RS19565	COG1696	Membrane protein involved in D-alanine export
E4413_RS19655	COG2154	pterin-4-alpha-carbinolamine dehydratase
E4413_RS19665	COG0745	RESPONSE REGULATOR receiver
E4413_RS19685	COG2885	chlorophyll binding
E4413_RS19700	COG0741	lytic transglycosylase activity
E4413_RS19705	COG5002	protein histidine kinase activity
E4413_RS19820	COG1028	Short-chain dehydrogenase reductase Sdr
E4413_RS19825	COG3852	Histidine kinase
E4413_RS19845	COG0069	glutamate synthase activity
E4413_RS19865	COG0811	peptide transport
E4413_RS19900	COG1703	isobutyryl-CoA mutase activity
E4413_RS19905	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
E4413_RS19905	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
E4413_RS19910	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
E4413_RS19930	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E4413_RS19935	COG0385	Bile acid
E4413_RS19975	COG0427	acetyl-CoA hydrolase
E4413_RS20015	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E4413_RS20035	COG0784	Response regulator, receiver
E4413_RS20035	COG5002	protein histidine kinase activity
E4413_RS20040	COG3706	GGDEF domain
E4413_RS20050	COG3706	GGDEF domain
E4413_RS20055	COG2200	EAL domain
E4413_RS20100	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
E4413_RS20135	COG0848	biopolymer transport protein
E4413_RS20140	COG1694	Mazg nucleotide pyrophosphohydrolase
E4413_RS20190	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
E4413_RS20195	COG1067	ATP-dependent peptidase activity