locus-tag	class	description
Y981_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Y981_RS00010	COG0592	DNA-directed DNA polymerase activity
Y981_RS00015	COG0187	DNA topoisomerase II activity
Y981_RS00020	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
Y981_RS00030	COG0602	queuosine metabolic process
Y981_RS00035	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
Y981_RS00040	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
Y981_RS00045	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
Y981_RS00050	COG0582	viral genome integration into host DNA
Y981_RS00055	COG0582	viral genome integration into host DNA
Y981_RS00110	COG2608	mercury ion transmembrane transporter activity
Y981_RS00110	COG2217	Heavy metal translocating P-type atpase
Y981_RS00120	COG0789	Transcriptional regulator
Y981_RS00230	COG0604	alcohol dehydrogenase
Y981_RS00235	COG1752	Esterase of the alpha-beta hydrolase superfamily
Y981_RS00240	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
Y981_RS00245	COG0494	nUDIX hydrolase
Y981_RS00250	COG1061	Type III restriction enzyme res subunit
Y981_RS00300	COG2226	methyltransferase
Y981_RS00310	COG2095	MarC family integral membrane protein
Y981_RS00325	COG5000	phosphorelay sensor kinase activity
Y981_RS00330	COG2204	response regulator
Y981_RS00370	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Y981_RS00390	COG0126	phosphoglycerate kinase activity
Y981_RS00395	COG0149	triose-phosphate isomerase activity
Y981_RS00405	COG0747	negative chemotaxis
Y981_RS00415	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Y981_RS00420	COG0546	phosphoglycolate phosphatase activity
Y981_RS00445	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
Y981_RS00455	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
Y981_RS00460	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
Y981_RS00465	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
Y981_RS00470	COG0355	proton-transporting ATP synthase activity, rotational mechanism
Y981_RS00475	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Y981_RS00495	COG0745	RESPONSE REGULATOR receiver
Y981_RS00500	COG5002	protein histidine kinase activity
Y981_RS00500	COG3850	Histidine kinase
Y981_RS00510	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Y981_RS00535	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Y981_RS00545	COG0346	lactoylglutathione lyase activity
Y981_RS00550	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Y981_RS00555	COG2022	thiamine diphosphate biosynthetic process
Y981_RS00560	COG0352	thiamine-phosphate diphosphorylase activity
Y981_RS00580	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Y981_RS00585	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
Y981_RS00595	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
Y981_RS00600	COG0072	phenylalanine-tRNA ligase activity
Y981_RS00610	COG4608	Belongs to the ABC transporter superfamily
Y981_RS00615	COG0444	Belongs to the ABC transporter superfamily
Y981_RS00640	COG0261	This protein binds to 23S rRNA in the presence of protein L20
Y981_RS00645	COG0211	Belongs to the bacterial ribosomal protein bL27 family
Y981_RS00650	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Y981_RS00655	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
Y981_RS00660	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
Y981_RS00680	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Y981_RS00685	COG1199	ATP-dependent helicase activity
Y981_RS00690	COG0583	DNA-binding transcription factor activity
Y981_RS00705	COG0670	Belongs to the BI1 family
Y981_RS00730	COG0237	dephospho-CoA kinase activity
Y981_RS00735	COG1210	Utp--glucose-1-phosphate uridylyltransferase
Y981_RS00740	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
Y981_RS00745	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
Y981_RS00765	COG2885	chlorophyll binding
Y981_RS00780	COG0557	exoribonuclease II activity
Y981_RS00800	COG1573	uracil-dna glycosylase
Y981_RS00845	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Y981_RS00880	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Y981_RS00885	COG3956	TIGRFAM MazG family protein
Y981_RS00930	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
Y981_RS00935	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
Y981_RS00940	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
Y981_RS01030	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
Y981_RS01055	COG2226	methyltransferase
Y981_RS01085	COG0840	transmembrane signaling receptor activity
Y981_RS01100	COG0404	The glycine cleavage system catalyzes the degradation of glycine
Y981_RS01105	COG0509	glycine decarboxylation via glycine cleavage system
Y981_RS01110	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Y981_RS01120	COG0095	Lipoate-protein ligase
Y981_RS01155	COG3852	Histidine kinase
Y981_RS01160	COG2204	response regulator
Y981_RS01165	COG1815	bacterial-type flagellum-dependent cell motility
Y981_RS01170	COG1558	bacterial-type flagellum-dependent cell motility
Y981_RS01180	COG1766	The M ring may be actively involved in energy transduction
Y981_RS01185	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Y981_RS01195	COG1157	protein secretion by the type III secretion system
Y981_RS01215	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
Y981_RS01240	COG1338	Plays a role in the flagellum-specific transport system
Y981_RS01245	COG1987	bacterial-type flagellum assembly
Y981_RS01255	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Y981_RS01275	COG1191	sigma factor activity
Y981_RS01280	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
Y981_RS01290	COG0643	Histidine kinase
Y981_RS01290	COG0784	Response regulator, receiver
Y981_RS01290	COG2198	Histidine kinase
Y981_RS01300	COG0840	transmembrane signaling receptor activity
Y981_RS01310	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
Y981_RS01435	COG0758	DNA mediated transformation
Y981_RS01440	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Y981_RS01445	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
Y981_RS01450	COG4974	Belongs to the 'phage' integrase family
Y981_RS01455	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
Y981_RS01465	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Y981_RS01480	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
Y981_RS01485	COG0815	Transfers the fatty acyl group on membrane lipoproteins
Y981_RS01600	COG0301	tRNA thio-modification
Y981_RS01605	COG2329	Antibiotic biosynthesis monooxygenase
Y981_RS01645	COG2255	four-way junction helicase activity
Y981_RS01650	COG0632	four-way junction helicase activity
Y981_RS01655	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
Y981_RS01660	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Y981_RS01665	COG4566	intracellular signal transduction
Y981_RS01670	COG3852	Histidine kinase
Y981_RS01675	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
Y981_RS01680	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Y981_RS01730	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Y981_RS01735	COG0601	transmembrane transport
Y981_RS01765	COG0004	ammonium transporteR
Y981_RS01770	COG0347	Belongs to the P(II) protein family
Y981_RS01775	COG0004	ammonium transporteR
Y981_RS01780	COG2217	Heavy metal translocating P-type atpase
Y981_RS01785	COG2199	diguanylate cyclase activity
Y981_RS01785	COG2200	EAL domain
Y981_RS01805	COG3118	belongs to the thioredoxin family
Y981_RS01810	COG0308	aminopeptidase N
Y981_RS01820	COG1742	UPF0060 membrane protein
Y981_RS01825	COG0556	nucleotide-excision repair
Y981_RS01845	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Y981_RS01850	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Y981_RS01885	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Y981_RS01895	COG1222	aaa ATPase
Y981_RS01900	COG4122	O-methyltransferase activity
Y981_RS01910	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
Y981_RS01915	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
Y981_RS01920	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
Y981_RS01955	COG5285	phytanoyl-CoA dioxygenase
Y981_RS01960	COG1917	Cupin 2, conserved barrel domain protein
Y981_RS02020	COG4983	Phage plasmid primase, P4 family domain protein
Y981_RS02065	COG1592	Rubrerythrin
Y981_RS02110	COG0037	tRNA processing
Y981_RS02115	COG2104	thiamine diphosphate biosynthetic process
Y981_RS02125	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
Y981_RS02140	COG0268	Binds directly to 16S ribosomal RNA
Y981_RS02155	COG0495	leucyl-tRNA aminoacylation
Y981_RS02175	COG0477	Major facilitator Superfamily
Y981_RS02190	COG0612	Peptidase, M16
Y981_RS02195	COG0612	Peptidase, M16
Y981_RS02235	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Y981_RS02240	COG1881	PFAM PEBP family protein
Y981_RS02260	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
Y981_RS02280	COG0489	protein tyrosine kinase activity
Y981_RS02290	COG2975	iron-sulfur cluster assembly
Y981_RS02300	COG0443	Heat shock 70 kDa protein
Y981_RS02310	COG0316	Belongs to the HesB IscA family
Y981_RS02315	COG0822	iron-sulfur transferase activity
Y981_RS02320	COG1104	cysteine desulfurase activity
Y981_RS02325	COG1959	2 iron, 2 sulfur cluster binding
Y981_RS02340	COG1253	flavin adenine dinucleotide binding
Y981_RS02355	COG2046	Belongs to the sulfate adenylyltransferase family
Y981_RS02375	COG1032	radical SAM domain protein
Y981_RS02380	COG2814	Major facilitator Superfamily
Y981_RS02385	COG4717	serine-type aminopeptidase activity
Y981_RS02390	COG0420	3'-5' exonuclease activity
Y981_RS02395	COG3586	endonuclease activity
Y981_RS02460	COG1294	oxidase, subunit
Y981_RS02470	COG0446	pyridine nucleotide-disulphide oxidoreductase
Y981_RS02500	COG2197	response regulator
Y981_RS02505	COG5002	protein histidine kinase activity
Y981_RS02510	COG1113	amino acid transport
Y981_RS02525	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
Y981_RS02565	COG2205	protein histidine kinase activity
Y981_RS02580	COG2084	Dehydrogenase
Y981_RS02585	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Y981_RS02610	COG1104	cysteine desulfurase activity
Y981_RS02665	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Y981_RS02710	COG0628	permease
Y981_RS02715	COG0066	3-isopropylmalate dehydratase activity
Y981_RS02720	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Y981_RS02730	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
Y981_RS02750	COG3300	MHYT domain
Y981_RS02750	COG5001	Diguanylate cyclase
Y981_RS02755	COG2062	phosphohistidine phosphatase, SixA
Y981_RS02760	COG0076	glutamate decarboxylase activity
Y981_RS02825	COG0366	Alpha amylase catalytic
Y981_RS02840	COG1064	alcohol dehydrogenase
Y981_RS02855	COG1024	Enoyl-CoA hydratase
Y981_RS02860	COG0784	Response regulator, receiver
Y981_RS02860	COG2198	Histidine kinase
Y981_RS02860	COG2205	protein histidine kinase activity
Y981_RS02895	COG1132	(ABC) transporter
Y981_RS02910	COG1215	transferase activity, transferring glycosyl groups
Y981_RS02915	COG1215	transferase activity, transferring glycosyl groups
Y981_RS02920	COG1215	transferase activity, transferring glycosyl groups
Y981_RS02935	COG2204	response regulator
Y981_RS02950	COG1210	Utp--glucose-1-phosphate uridylyltransferase
Y981_RS02960	COG5002	protein histidine kinase activity
Y981_RS02970	COG1215	transferase activity, transferring glycosyl groups
Y981_RS02995	COG0438	transferase activity, transferring glycosyl groups
Y981_RS03000	COG0438	transferase activity, transferring glycosyl groups
Y981_RS03005	COG1215	transferase activity, transferring glycosyl groups
Y981_RS03030	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
Y981_RS03055	COG0668	transmembrane transport
Y981_RS03060	COG2199	diguanylate cyclase activity
Y981_RS03085	COG1672	PFAM Archaeal ATPase
Y981_RS03085	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
Y981_RS03100	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Y981_RS03225	COG0045	succinate-CoA ligase (ADP-forming) activity
Y981_RS03230	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
Y981_RS03235	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Y981_RS03240	COG0372	Belongs to the citrate synthase family
Y981_RS03260	COG0045	succinate-CoA ligase (ADP-forming) activity
Y981_RS03265	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
Y981_RS03270	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
Y981_RS03285	COG2001	Belongs to the MraZ family
Y981_RS03290	COG0275	rRNA processing
Y981_RS03300	COG0768	penicillin binding
Y981_RS03305	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Y981_RS03310	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
Y981_RS03315	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Y981_RS03320	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
Y981_RS03325	COG0772	Belongs to the SEDS family
Y981_RS03335	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Y981_RS03340	COG0812	UDP-N-acetylmuramate dehydrogenase activity
Y981_RS03345	COG1181	Belongs to the D-alanine--D-alanine ligase family
Y981_RS03360	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
Y981_RS03365	COG1496	oxidoreductase activity
Y981_RS03375	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
Y981_RS03380	COG0762	integral membrane protein
Y981_RS03410	COG1657	PFAM Prenyltransferase squalene oxidase
Y981_RS03430	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Y981_RS03435	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
Y981_RS03465	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
Y981_RS03470	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Y981_RS03490	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
Y981_RS03495	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
Y981_RS03505	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
Y981_RS03510	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
Y981_RS03520	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
Y981_RS03530	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
Y981_RS03545	COG5002	protein histidine kinase activity
Y981_RS03550	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
Y981_RS03560	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
Y981_RS03565	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
Y981_RS03570	COG1127	ABC transporter
Y981_RS03600	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
Y981_RS03605	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
Y981_RS03620	COG1674	ftsk spoiiie
Y981_RS03625	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
Y981_RS03630	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Y981_RS03655	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
Y981_RS03655	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
Y981_RS03660	COG1418	mRNA catabolic process
Y981_RS03675	COG1722	exodeoxyribonuclease VII activity
Y981_RS03685	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Y981_RS03695	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Y981_RS03700	COG1324	tolerance protein
Y981_RS03710	COG0653	protein targeting
Y981_RS03715	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Y981_RS03720	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Y981_RS03725	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Y981_RS03750	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
Y981_RS03765	COG0713	ATP synthesis coupled electron transport
Y981_RS03785	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
Y981_RS03795	COG0004	ammonium transporteR
Y981_RS03800	COG0347	Belongs to the P(II) protein family
Y981_RS03815	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
Y981_RS03860	COG3156	type II secretion system protein K
Y981_RS03880	COG2165	general secretion pathway protein
Y981_RS03885	COG1459	type II secretion system
Y981_RS03930	COG3258	Cytochrome c
Y981_RS03960	COG0457	Tetratricopeptide repeat
Y981_RS03965	COG1215	transferase activity, transferring glycosyl groups
Y981_RS03985	COG3258	Cytochrome c
Y981_RS04005	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
Y981_RS04010	COG0166	Belongs to the GPI family
Y981_RS04045	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
Y981_RS04050	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Y981_RS04080	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
Y981_RS04085	COG1022	Amp-dependent synthetase and ligase
Y981_RS04095	COG1959	2 iron, 2 sulfur cluster binding
Y981_RS04105	COG0543	2 iron, 2 sulfur cluster binding
Y981_RS04105	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
Y981_RS04125	COG1017	nitric oxide dioxygenase activity
Y981_RS04125	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
Y981_RS04135	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
Y981_RS04135	COG0662	Cupin 2, conserved barrel domain protein
Y981_RS04240	COG0300	oxidoreductase activity
Y981_RS04245	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
Y981_RS04265	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
Y981_RS04270	COG1217	gtp-binding protein TYPA
Y981_RS04280	COG1234	tRNA 3'-trailer cleavage
Y981_RS04285	COG1410	methionine synthase
Y981_RS04285	COG0646	methionine synthase
Y981_RS04300	COG0542	response to heat
Y981_RS04305	COG0322	excinuclease ABC activity
Y981_RS04315	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Y981_RS04320	COG0552	protein localization to endoplasmic reticulum
Y981_RS04325	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
Y981_RS04330	COG1480	7TM receptor with intracellular HD hydrolase
Y981_RS04345	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
Y981_RS04355	COG2326	polyphosphate kinase activity
Y981_RS04370	COG0784	Response regulator, receiver
Y981_RS04370	COG0835	chemotaxis
Y981_RS04385	COG0779	Required for maturation of 30S ribosomal subunits
Y981_RS04390	COG0195	Participates in both transcription termination and antitermination
Y981_RS04395	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
Y981_RS04405	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
Y981_RS04415	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
Y981_RS04420	COG1185	polyribonucleotide nucleotidyltransferase activity
Y981_RS04425	COG0612	Peptidase, M16
Y981_RS04430	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
Y981_RS04435	COG0736	holo-[acyl-carrier-protein] synthase activity
Y981_RS04440	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
Y981_RS04440	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
Y981_RS04445	COG1573	uracil-dna glycosylase
Y981_RS04455	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
Y981_RS04475	COG0723	plastoquinol--plastocyanin reductase activity
Y981_RS04505	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
Y981_RS04520	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
Y981_RS04520	COG3620	sequence-specific DNA binding
Y981_RS04520	COG0617	tRNA 3'-terminal CCA addition
Y981_RS04565	COG0539	negative regulation of cytoplasmic translation
Y981_RS04565	COG2183	response to ionizing radiation
Y981_RS04570	COG0616	signal peptide processing
Y981_RS04575	COG0776	regulation of translation
Y981_RS04580	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
Y981_RS04585	COG0228	four-way junction DNA binding
Y981_RS04590	COG1837	Belongs to the UPF0109 family
Y981_RS04595	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
Y981_RS04600	COG0336	Belongs to the RNA methyltransferase TrmD family
Y981_RS04605	COG0335	large ribosomal subunit rRNA binding
Y981_RS04610	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
Y981_RS04625	COG0793	Belongs to the peptidase S41A family
Y981_RS04630	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
Y981_RS04635	COG0459	protein refolding
Y981_RS04645	COG0497	DNA recombination
Y981_RS04650	COG1615	UPF0182 protein
Y981_RS04655	COG1982	Orn Lys Arg decarboxylase major
Y981_RS04660	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
Y981_RS04665	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
Y981_RS04670	COG3706	GGDEF domain
Y981_RS04690	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
Y981_RS04695	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Y981_RS04705	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
Y981_RS04710	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
Y981_RS04715	COG0525	valine-tRNA ligase activity
Y981_RS04720	COG0157	Belongs to the NadC ModD family
Y981_RS04730	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
Y981_RS04755	COG1566	PFAM secretion protein HlyD family protein
Y981_RS04795	COG1660	Displays ATPase and GTPase activities
Y981_RS04805	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
Y981_RS04810	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
Y981_RS04815	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
Y981_RS04840	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
Y981_RS04900	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
Y981_RS04970	COG1196	nuclear chromosome segregation
Y981_RS04975	COG4717	serine-type aminopeptidase activity
Y981_RS04980	COG0420	3'-5' exonuclease activity
Y981_RS05000	COG2801	Transposase and inactivated derivatives
Y981_RS05000	COG3415	Transposase
Y981_RS05010	COG1111	helicase
Y981_RS05010	COG1205	dead DEAH box helicase
Y981_RS05015	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Y981_RS05055	COG3657	addiction module killer protein
Y981_RS05100	COG3657	addiction module killer protein
Y981_RS05130	COG0542	response to heat
Y981_RS05135	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Y981_RS05145	COG0343	queuine tRNA-ribosyltransferase activity
Y981_RS05155	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Y981_RS05160	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Y981_RS05200	COG2814	Major facilitator Superfamily
Y981_RS05205	COG1538	Outer membrane efflux protein
Y981_RS05210	COG1566	PFAM secretion protein HlyD family protein
Y981_RS05220	COG1420	regulation of RNA biosynthetic process
Y981_RS05230	COG0443	Heat shock 70 kDa protein
Y981_RS05235	COG0484	heat shock protein binding
Y981_RS05260	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
Y981_RS05265	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
Y981_RS05295	COG0667	Aldo Keto reductase
Y981_RS05300	COG0406	alpha-ribazole phosphatase activity
Y981_RS05305	COG1797	cobyrinic acid a,c-diamide synthase activity
Y981_RS05320	COG0473	3-isopropylmalate dehydrogenase activity
Y981_RS05335	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Y981_RS05345	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Y981_RS05350	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Y981_RS05365	COG0673	inositol 2-dehydrogenase activity
Y981_RS05370	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Y981_RS05380	COG1132	(ABC) transporter
Y981_RS05385	COG1519	Transferase
Y981_RS05395	COG1560	Kdo2-lipid A biosynthetic process
Y981_RS05410	COG0859	PFAM glycosyl transferase family 9
Y981_RS05415	COG0463	Glycosyl transferase, family 2
Y981_RS05430	COG0275	rRNA processing
Y981_RS05440	COG0463	Glycosyl transferase, family 2
Y981_RS05440	COG1216	Glycosyl transferase, family 2
Y981_RS05460	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
Y981_RS05465	COG2835	tetraacyldisaccharide 4'-kinase activity
Y981_RS05480	COG0726	polysaccharide deacetylase
Y981_RS05485	COG0438	transferase activity, transferring glycosyl groups
Y981_RS05510	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
Y981_RS05525	COG4956	integral membrane protein (PIN domain superfamily)
Y981_RS05530	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
Y981_RS05530	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
Y981_RS05535	COG1045	serine acetyltransferase
Y981_RS05540	COG0671	phosphoesterase, PA-phosphatase related
Y981_RS05555	COG0463	Glycosyl transferase, family 2
Y981_RS05560	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
Y981_RS05570	COG0151	Belongs to the GarS family
Y981_RS05590	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
Y981_RS05605	COG1136	(ABC) transporter
Y981_RS05615	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
Y981_RS05620	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
Y981_RS05630	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
Y981_RS05645	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Y981_RS05655	COG2226	methyltransferase
Y981_RS05670	COG0436	Aminotransferase
Y981_RS05685	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
Y981_RS05695	COG0527	aspartate kinase activity
Y981_RS05700	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Y981_RS05705	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Y981_RS05710	COG0776	regulation of translation
Y981_RS05725	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
Y981_RS05735	COG0215	cysteine-tRNA ligase activity
Y981_RS05740	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Y981_RS05745	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Y981_RS05750	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Y981_RS05750	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
Y981_RS05755	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Y981_RS05755	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Y981_RS05760	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
Y981_RS05765	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Y981_RS05775	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
Y981_RS05780	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
Y981_RS05785	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Y981_RS05800	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
Y981_RS05805	COG2226	methyltransferase
Y981_RS05820	COG0842	Transport permease protein
Y981_RS05825	COG0842	Transport permease protein
Y981_RS05830	COG1131	(ABC) transporter
Y981_RS05850	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
Y981_RS05860	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Y981_RS05865	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Y981_RS05905	COG0477	Major facilitator Superfamily
Y981_RS05920	COG0488	(ABC) transporter
Y981_RS05940	COG2885	chlorophyll binding
Y981_RS06005	COG3189	MarR family transcriptional regulator
Y981_RS06015	COG1994	Peptidase M50
Y981_RS06020	COG0180	Tryptophanyl-tRNA synthetase
Y981_RS06025	COG0825	malonyl-CoA metabolic process
Y981_RS06045	COG0840	transmembrane signaling receptor activity
Y981_RS06075	COG4166	transmembrane transport
Y981_RS06080	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
Y981_RS06085	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Y981_RS06090	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
Y981_RS06095	COG0305	Participates in initiation and elongation during chromosome replication
Y981_RS06115	COG1278	Cold shock
Y981_RS06130	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
Y981_RS06135	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
Y981_RS06190	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
Y981_RS06195	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
Y981_RS06220	COG1388	LysM domain
Y981_RS06220	COG3942	CHAP domain
Y981_RS06225	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Y981_RS06225	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Y981_RS06230	COG0297	glycogen (starch) synthase activity
Y981_RS06245	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Y981_RS06260	COG4974	Belongs to the 'phage' integrase family
Y981_RS06265	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Y981_RS06275	COG0714	Associated with various cellular activities
Y981_RS06320	COG2084	Dehydrogenase
Y981_RS06330	COG0577	efflux transmembrane transporter activity
Y981_RS06360	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
Y981_RS06370	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Y981_RS06425	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
Y981_RS06435	COG0105	UTP biosynthetic process
Y981_RS06445	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Y981_RS06450	COG1489	DNA binding
Y981_RS06460	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Y981_RS06475	COG0217	transcriptional regulatory protein
Y981_RS06480	COG0077	Prephenate dehydratase
Y981_RS06480	COG1605	Chorismate mutase
Y981_RS06485	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
Y981_RS06490	COG0287	Prephenate dehydrogenase
Y981_RS06495	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
Y981_RS06500	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
Y981_RS06505	COG0204	Acyl-transferase
Y981_RS06520	COG0302	gtp cyclohydrolase
Y981_RS06525	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Y981_RS06530	COG0646	methionine synthase
Y981_RS06530	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
Y981_RS06565	COG0277	FAD linked oxidase domain protein
Y981_RS06570	COG3481	metal-dependent phosphohydrolase, HD sub domain
Y981_RS06575	COG0070	glutamate synthase
Y981_RS06575	COG0069	glutamate synthase activity
Y981_RS06575	COG0067	glutamate synthase
Y981_RS06590	COG1254	Belongs to the acylphosphatase family
Y981_RS06600	COG0114	fumarate hydratase activity
Y981_RS06610	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Y981_RS06615	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
Y981_RS06620	COG1492	cobalamin metabolic process
Y981_RS06695	COG1959	2 iron, 2 sulfur cluster binding
Y981_RS06700	COG3189	MarR family transcriptional regulator
Y981_RS06715	COG0129	dihydroxy-acid dehydratase activity
Y981_RS06720	COG1322	Protein conserved in bacteria
Y981_RS06725	COG1950	PFAM Membrane protein of
Y981_RS06785	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
Y981_RS06790	COG0307	riboflavin synthase, alpha
Y981_RS06795	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Y981_RS06795	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Y981_RS06800	COG0751	glycine-tRNA ligase activity
Y981_RS06805	COG0752	glycyl-tRNA synthetase alpha subunit
Y981_RS06820	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Y981_RS06830	COG0156	8-amino-7-oxononanoate synthase activity
Y981_RS06850	COG1561	YicC-like family, N-terminal region
Y981_RS06855	COG2052	Domain of unknown function (DUF370)
Y981_RS06860	COG0194	GDP metabolic process
Y981_RS06865	COG1758	RNA polymerase activity
Y981_RS06870	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
Y981_RS06880	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
Y981_RS06885	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
Y981_RS06890	COG0511	ligase activity, forming carbon-carbon bonds
Y981_RS06895	COG0439	Biotin carboxylase
Y981_RS06900	COG0352	thiamine-phosphate diphosphorylase activity
Y981_RS06910	COG0784	Response regulator, receiver
Y981_RS06995	COG1129	ABC transporter
Y981_RS06995	COG0842	Transport permease protein
Y981_RS07015	COG0583	DNA-binding transcription factor activity
Y981_RS07025	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Y981_RS07055	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Y981_RS07060	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
Y981_RS07070	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Y981_RS07085	COG0438	transferase activity, transferring glycosyl groups
Y981_RS07090	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
Y981_RS07100	COG1091	dTDP-4-dehydrorhamnose reductase activity
Y981_RS07110	COG0203	ribosomal protein L17
Y981_RS07115	COG0202	RNA polymerase activity
Y981_RS07120	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
Y981_RS07125	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Y981_RS07130	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
Y981_RS07145	COG0201	protein transport
Y981_RS07150	COG0200	Binds to the 23S rRNA
Y981_RS07155	COG1841	ribosomal large subunit assembly
Y981_RS07160	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
Y981_RS07165	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
Y981_RS07170	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
Y981_RS07175	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Y981_RS07180	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
Y981_RS07185	COG0255	Belongs to the universal ribosomal protein uL29 family
Y981_RS07190	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
Y981_RS07195	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
Y981_RS07200	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
Y981_RS07210	COG0089	rRNA binding
Y981_RS07215	COG0088	Forms part of the polypeptide exit tunnel
Y981_RS07220	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
Y981_RS07225	COG0051	transcription antitermination factor activity, RNA binding
Y981_RS07230	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Y981_RS07235	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Y981_RS07240	COG0049	tRNA binding
Y981_RS07245	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
Y981_RS07250	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Y981_RS07255	COG0085	RNA polymerase activity
Y981_RS07260	COG0222	ribosome binding
Y981_RS07265	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
Y981_RS07275	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
Y981_RS07295	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Y981_RS07320	COG1252	NADH dehydrogenase
Y981_RS07335	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Y981_RS07350	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
Y981_RS07360	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
Y981_RS07365	COG0629	single-stranded DNA binding
Y981_RS07370	COG0360	Binds together with S18 to 16S ribosomal RNA
Y981_RS07375	COG0012	GTP binding
Y981_RS07380	COG0193	aminoacyl-tRNA hydrolase activity
Y981_RS07385	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
Y981_RS07390	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Y981_RS07400	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
Y981_RS07425	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
Y981_RS07430	COG0740	serine-type endopeptidase activity
Y981_RS07435	COG0544	peptidyl-prolyl cis-trans isomerase activity
Y981_RS07450	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
Y981_RS07455	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
Y981_RS07460	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
Y981_RS07465	COG0363	glucosamine-6-phosphate deaminase activity
Y981_RS07470	COG0837	glucose binding
Y981_RS07515	COG0535	radical SAM domain protein
Y981_RS07525	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
Y981_RS07590	COG0667	Aldo Keto reductase
Y981_RS07600	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
Y981_RS07645	COG2308	Evidence 4 Homologs of previously reported genes of
Y981_RS07665	COG0651	ATP synthesis coupled electron transport
Y981_RS07680	COG0651	ATP synthesis coupled electron transport
Y981_RS07685	COG0649	NAD binding
Y981_RS07690	COG3260	NADH ubiquinone oxidoreductase 20
Y981_RS07735	COG4691	Plasmid stability protein
Y981_RS07740	COG1487	ribonuclease activity
Y981_RS07820	COG0529	Catalyzes the synthesis of activated sulfate
Y981_RS07820	COG2046	Belongs to the sulfate adenylyltransferase family
Y981_RS07830	COG3335	DDE superfamily endonuclease
Y981_RS07835	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
Y981_RS07840	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
Y981_RS07875	COG0438	transferase activity, transferring glycosyl groups
Y981_RS07880	COG1012	belongs to the aldehyde dehydrogenase family
Y981_RS07900	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Y981_RS07905	COG3002	Belongs to the UPF0753 family
Y981_RS07915	COG0129	dihydroxy-acid dehydratase activity
Y981_RS07920	COG0009	L-threonylcarbamoyladenylate synthase
Y981_RS07925	COG0129	dihydroxy-acid dehydratase activity
Y981_RS07940	COG3002	Belongs to the UPF0753 family
Y981_RS07950	COG2204	response regulator
Y981_RS07955	COG0840	transmembrane signaling receptor activity
Y981_RS08005	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
Y981_RS08025	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Y981_RS08040	COG0347	Belongs to the P(II) protein family
Y981_RS08055	COG4231	catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates
Y981_RS08070	COG5554	nitrogen fixation
Y981_RS08080	COG5554	nitrogen fixation
Y981_RS08110	COG0316	Belongs to the HesB IscA family
Y981_RS08115	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
Y981_RS08135	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
Y981_RS08140	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
Y981_RS08145	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
Y981_RS08155	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
Y981_RS08255	COG0477	Major facilitator Superfamily
Y981_RS08260	COG1902	pentaerythritol trinitrate reductase activity
Y981_RS08265	COG0697	spore germination
Y981_RS08270	COG0579	oxidoreductase
Y981_RS08280	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Y981_RS08285	COG3278	Belongs to the heme-copper respiratory oxidase family
Y981_RS08310	COG0820	rRNA (adenine-C2-)-methyltransferase activity
Y981_RS08315	COG0671	phosphoesterase, PA-phosphatase related
Y981_RS08335	COG0730	response to heat
Y981_RS08350	COG0784	Response regulator, receiver
Y981_RS08350	COG5002	protein histidine kinase activity
Y981_RS08355	COG0739	heme binding
Y981_RS08365	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Y981_RS08375	COG0517	IMP dehydrogenase activity
Y981_RS08375	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
Y981_RS08380	COG2877	3-deoxy-8-phosphooctulonate synthase activity
Y981_RS08385	COG0504	CTP synthase activity
Y981_RS08390	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
Y981_RS08405	COG0481	GTPase activity
Y981_RS08420	COG0124	histidyl-tRNA synthetase
Y981_RS08430	COG2207	Transcriptional regulator
Y981_RS08435	COG0667	Aldo Keto reductase
Y981_RS08485	COG0438	transferase activity, transferring glycosyl groups
Y981_RS08485	COG1216	Glycosyl transferase, family 2
Y981_RS08505	COG3335	DDE superfamily endonuclease
Y981_RS08535	COG1484	DNA-dependent DNA replication
Y981_RS08540	COG2390	Transcriptional regulator
Y981_RS08540	COG4584	PFAM Integrase catalytic
Y981_RS08545	COG4584	PFAM Integrase catalytic
Y981_RS08545	COG2390	Transcriptional regulator
Y981_RS08560	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Y981_RS08565	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
Y981_RS08575	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
Y981_RS08580	COG0815	Transfers the fatty acyl group on membrane lipoproteins
Y981_RS08595	COG1793	dna ligase
Y981_RS08625	COG0517	IMP dehydrogenase activity
Y981_RS08625	COG0516	GMP reductase activity
Y981_RS08630	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Y981_RS08630	COG0519	Catalyzes the synthesis of GMP from XMP
Y981_RS08640	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
Y981_RS08675	COG0316	Belongs to the HesB IscA family
Y981_RS08685	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Y981_RS08690	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Y981_RS08700	COG0505	Belongs to the CarA family
Y981_RS08705	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Y981_RS08710	COG0540	Belongs to the ATCase OTCase family
Y981_RS08715	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
Y981_RS08775	COG2379	hydroxypyruvate reductase
Y981_RS08785	COG0616	signal peptide processing
Y981_RS08790	COG1666	GTP binding
Y981_RS08800	COG1131	(ABC) transporter
Y981_RS08830	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
Y981_RS08830	COG0493	'glutamate synthase
Y981_RS08840	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Y981_RS08850	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
Y981_RS08860	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
Y981_RS08865	COG0159	tryptophan synthase activity
Y981_RS08875	COG0135	phosphoribosylanthranilate isomerase activity
Y981_RS08885	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Y981_RS08890	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Y981_RS08890	COG0512	Glutamine amidotransferase of anthranilate synthase
Y981_RS08905	COG0494	nUDIX hydrolase
Y981_RS08995	COG0083	homoserine kinase activity
Y981_RS09005	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
Y981_RS09015	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
Y981_RS09025	COG4122	O-methyltransferase activity
Y981_RS09030	COG1222	aaa ATPase
Y981_RS09040	COG0778	Nitroreductase
Y981_RS09045	COG1509	lysine 2,3-aminomutase activity
Y981_RS09060	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
Y981_RS09065	COG0181	hydroxymethylbilane synthase activity
Y981_RS09075	COG0113	porphobilinogen synthase activity
Y981_RS09080	COG0196	riboflavin kinase activity
Y981_RS09090	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
Y981_RS09095	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Y981_RS09100	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
Y981_RS09105	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
Y981_RS09120	COG3180	Ammonia monooxygenase
Y981_RS09125	COG1335	isochorismatase
Y981_RS09135	COG0025	NhaP-type Na H and K H
Y981_RS09165	COG1566	PFAM secretion protein HlyD family protein
Y981_RS09175	COG0415	Belongs to the DNA photolyase family
Y981_RS09180	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
Y981_RS09210	COG3077	Addiction module antitoxin, RelB DinJ family
Y981_RS09215	COG3041	Addiction module toxin RelE StbE family
Y981_RS09230	COG0811	peptide transport
Y981_RS09235	COG0848	biopolymer transport protein
Y981_RS09250	COG0745	RESPONSE REGULATOR receiver
Y981_RS09265	COG1074	ATP-dependent DNA helicase activity
Y981_RS09270	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
Y981_RS09300	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Y981_RS09315	COG5001	Diguanylate cyclase
Y981_RS09315	COG3447	MASE1 domain protein
Y981_RS09315	COG5002	protein histidine kinase activity
Y981_RS09355	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Y981_RS09360	COG1959	2 iron, 2 sulfur cluster binding
Y981_RS09365	COG1902	pentaerythritol trinitrate reductase activity
Y981_RS09415	COG2204	response regulator
Y981_RS09440	COG0148	phosphopyruvate hydratase activity
Y981_RS09455	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Y981_RS09460	COG0154	amidase activity
Y981_RS09465	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
Y981_RS09470	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Y981_RS09475	COG0210	DNA helicase
Y981_RS09485	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Y981_RS09515	COG0640	Transcriptional regulator
Y981_RS09525	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
Y981_RS09540	COG1846	Transcriptional regulator
Y981_RS09545	COG0235	Class ii aldolase
Y981_RS09565	COG0450	alkyl hydroperoxide reductase
Y981_RS09570	COG1858	cytochrome C peroxidase
Y981_RS09590	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
Y981_RS09595	COG0470	DNA polymerase III
Y981_RS09600	COG1774	PSP1 C-terminal conserved region
Y981_RS09605	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Y981_RS09605	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Y981_RS09610	COG0084	hydrolase, TatD family'
Y981_RS09625	COG0531	amino acid
Y981_RS09645	COG0531	amino acid
Y981_RS09650	COG1252	NADH dehydrogenase
Y981_RS09670	COG1160	GTP binding
Y981_RS09675	COG0574	Belongs to the PEP-utilizing enzyme family
Y981_RS09675	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Y981_RS09725	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
Y981_RS09740	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
Y981_RS09745	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
Y981_RS09760	COG0571	ribonuclease III activity
Y981_RS09765	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Y981_RS09775	COG1028	Short-chain dehydrogenase reductase Sdr
Y981_RS09785	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Y981_RS09790	COG0416	fatty acid biosynthetic process
Y981_RS09805	COG0442	prolyl-tRNA aminoacylation
Y981_RS09810	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
Y981_RS09815	COG0750	zinc metalloprotease
Y981_RS09830	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
Y981_RS09840	COG2759	Belongs to the formate--tetrahydrofolate ligase family
Y981_RS09845	COG1968	undecaprenyl-diphosphatase activity
Y981_RS09850	COG0805	protein transport
Y981_RS09875	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
Y981_RS09890	COG0312	modulator of DNA gyrase
Y981_RS09895	COG0312	modulator of DNA gyrase
Y981_RS09910	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
Y981_RS09915	COG1562	ergosterol biosynthetic process
Y981_RS09925	COG1192	Involved in chromosome partitioning
Y981_RS09935	COG1619	proteins homologs of microcin C7 resistance protein MccF
Y981_RS10040	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
Y981_RS10085	COG1396	sequence-specific DNA binding
Y981_RS10160	COG3657	addiction module killer protein
Y981_RS10165	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
Y981_RS10215	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
Y981_RS10220	COG0588	phosphoglycerate mutase activity
Y981_RS10230	COG0513	Belongs to the DEAD box helicase family
Y981_RS10235	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
Y981_RS10240	COG1472	Belongs to the glycosyl hydrolase 3 family
Y981_RS10245	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
Y981_RS10250	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
Y981_RS10260	COG0488	(ABC) transporter
Y981_RS10275	COG1187	pseudouridine synthase activity
Y981_RS10290	COG0328	RNA-DNA hybrid ribonuclease activity
Y981_RS10325	COG0776	regulation of translation
Y981_RS10330	COG0537	adenosine 5'-monophosphoramidase activity
Y981_RS10340	COG0107	imidazoleglycerol-phosphate synthase activity
Y981_RS10345	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
Y981_RS10360	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Y981_RS10365	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
Y981_RS10370	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
Y981_RS10375	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Y981_RS10380	COG2890	protein-(glutamine-N5) methyltransferase activity
Y981_RS10385	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
Y981_RS10390	COG0254	rRNA binding
Y981_RS10395	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
Y981_RS10410	COG0123	including yeast histone deacetylase and acetoin utilization protein
Y981_RS10425	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
Y981_RS10430	COG1012	belongs to the aldehyde dehydrogenase family
Y981_RS10440	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
Y981_RS10450	COG0704	Plays a role in the regulation of phosphate uptake
Y981_RS10455	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Y981_RS10460	COG0581	inorganic phosphate transmembrane transporter activity
Y981_RS10470	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
Y981_RS10480	COG0745	RESPONSE REGULATOR receiver
Y981_RS10500	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
Y981_RS10520	COG2003	Belongs to the UPF0758 family
Y981_RS10545	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
Y981_RS10555	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
Y981_RS10580	COG3002	Belongs to the UPF0753 family
Y981_RS10610	COG1136	(ABC) transporter
Y981_RS10610	COG0577	efflux transmembrane transporter activity
Y981_RS10615	COG1136	(ABC) transporter
Y981_RS10680	COG1516	flagellar protein fliS
Y981_RS10690	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
Y981_RS10695	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
Y981_RS10710	COG1256	bacterial-type flagellum assembly
Y981_RS10725	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
Y981_RS10735	COG1706	bacterial-type flagellum-dependent cell motility
Y981_RS10755	COG4786	Flagellar basal body rod
Y981_RS10765	COG0179	Fumarylacetoacetate (FAA) hydrolase
Y981_RS10785	COG0019	diaminopimelate decarboxylase activity
Y981_RS10790	COG0165	Argininosuccinate lyase
Y981_RS10795	COG0137	argininosuccinate synthase activity
Y981_RS10800	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Y981_RS10805	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Y981_RS10810	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
Y981_RS10810	COG0475	glutathione-regulated potassium exporter activity
Y981_RS10815	COG2814	Major facilitator Superfamily
Y981_RS10840	COG2226	methyltransferase
Y981_RS10855	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
Y981_RS10860	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
Y981_RS10870	COG0698	ribose 5-phosphate isomerase
Y981_RS10875	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Y981_RS10880	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
Y981_RS10885	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
Y981_RS10895	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
Y981_RS10900	COG0785	Cytochrome C biogenesis protein
Y981_RS10905	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Y981_RS10910	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Y981_RS10915	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Y981_RS10920	COG1333	cytochrome c biogenesis protein
Y981_RS10930	COG1127	ABC transporter
Y981_RS10935	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
Y981_RS10940	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
Y981_RS10945	COG0233	cytoplasmic translational termination
Y981_RS10950	COG0528	UMP kinase activity
Y981_RS10955	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
Y981_RS10960	COG0052	Belongs to the universal ribosomal protein uS2 family
Y981_RS10965	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
Y981_RS10970	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
Y981_RS10975	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Y981_RS10980	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
Y981_RS10985	COG1032	radical SAM domain protein
Y981_RS10990	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
Y981_RS11010	COG1530	ribonuclease E activity
Y981_RS11015	COG0772	Belongs to the SEDS family
Y981_RS11020	COG0768	penicillin binding
Y981_RS11035	COG1077	Cell shape determining protein MreB Mrl
Y981_RS11045	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
Y981_RS11055	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Y981_RS11060	COG0242	peptide deformylase activity
Y981_RS11075	COG1331	Highly conserved protein containing a thioredoxin domain
Y981_RS11105	COG2204	response regulator
Y981_RS11110	COG0404	The glycine cleavage system catalyzes the degradation of glycine
Y981_RS11130	COG1543	Belongs to the glycosyl hydrolase 57 family
Y981_RS11145	COG1449	Belongs to the glycosyl hydrolase 57 family
Y981_RS11155	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
Y981_RS11195	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Y981_RS11215	COG0542	response to heat
Y981_RS11225	COG0484	heat shock protein binding
Y981_RS11230	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
Y981_RS11240	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Y981_RS11270	COG1013	pyruvate-flavodoxin oxidoreductase activity
Y981_RS11275	COG0674	pyruvate-flavodoxin oxidoreductase activity
Y981_RS11295	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
Y981_RS11295	COG0674	pyruvate-flavodoxin oxidoreductase activity
Y981_RS11295	COG1013	pyruvate-flavodoxin oxidoreductase activity
Y981_RS11295	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Y981_RS11305	COG0484	heat shock protein binding
Y981_RS11315	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Y981_RS11320	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
Y981_RS11325	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
Y981_RS11325	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
Y981_RS11330	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
Y981_RS11340	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Y981_RS11345	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Y981_RS11350	COG0218	Necessary for normal cell division and for the maintenance of normal septation
Y981_RS11370	COG2855	membrane
Y981_RS11390	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
Y981_RS11395	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
Y981_RS11405	COG0564	pseudouridine synthase activity
Y981_RS11415	COG0142	geranyltranstransferase activity
Y981_RS11440	COG1892	Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four- carbon dicarboxylic acid source for the tricarboxylic acid cycle
Y981_RS11450	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
Y981_RS11470	COG0425	Belongs to the sulfur carrier protein TusA family
Y981_RS11475	COG0571	ribonuclease III activity
Y981_RS11485	COG0482	sulfurtransferase activity
Y981_RS11495	COG1475	DNA binding
Y981_RS11505	COG0357	Ribosomal RNA small subunit methyltransferase G
Y981_RS11510	COG0445	tRNA wobble uridine modification
Y981_RS11515	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
Y981_RS11520	COG0706	membrane insertase activity
Y981_RS11525	COG0359	binds to the 23S rRNA
Y981_RS11530	COG1970	mechanosensitive ion channel activity
Y981_RS11545	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
Y981_RS11580	COG0284	orotidine-5'-phosphate decarboxylase activity
Y981_RS11610	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
Y981_RS11620	COG1850	ribulose-bisphosphate carboxylase activity
Y981_RS11625	COG1032	radical SAM domain protein
Y981_RS11675	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
Y981_RS11680	COG0473	3-isopropylmalate dehydrogenase activity
Y981_RS11685	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Y981_RS11690	COG1183	phosphatidylcholine synthase activity
Y981_RS11695	COG0688	phosphatidylethanolamine metabolic process
Y981_RS11700	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
Y981_RS11705	COG0440	acetolactate synthase activity
Y981_RS11710	COG0028	Belongs to the TPP enzyme family
Y981_RS11725	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Y981_RS11725	COG1648	precorrin-2 dehydrogenase activity
Y981_RS11735	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Y981_RS11805	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
Y981_RS11810	COG0101	tRNA pseudouridine synthase activity
Y981_RS11815	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
Y981_RS11845	COG0438	transferase activity, transferring glycosyl groups
Y981_RS11855	COG2204	response regulator
Y981_RS11870	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Y981_RS11875	COG1872	DUF167
Y981_RS11880	COG1570	exodeoxyribonuclease VII activity
Y981_RS11885	COG0739	heme binding
Y981_RS11895	COG5001	Diguanylate cyclase
Y981_RS11895	COG4251	negative regulation of phosphorylation
Y981_RS11895	COG3706	GGDEF domain
Y981_RS11895	COG2203	Gaf domain
Y981_RS11905	COG1381	Involved in DNA repair and RecF pathway recombination
Y981_RS11915	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
Y981_RS11940	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
Y981_RS11955	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
Y981_RS11960	COG0739	heme binding
Y981_RS11975	COG1215	transferase activity, transferring glycosyl groups
Y981_RS11980	COG1663	tetraacyldisaccharide 4'-kinase activity
Y981_RS11995	COG0742	ribosomal rna small subunit methyltransferase
Y981_RS12010	COG0860	N-Acetylmuramoyl-L-alanine amidase
Y981_RS12030	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Y981_RS12035	COG1424	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
Y981_RS12040	COG4251	negative regulation of phosphorylation
Y981_RS12045	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
Y981_RS12055	COG1848	Toxic component of a toxin-antitoxin (TA) module. An RNase
Y981_RS12060	COG2199	diguanylate cyclase activity
Y981_RS12060	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
Y981_RS12130	COG0463	Glycosyl transferase, family 2
Y981_RS12135	COG1187	pseudouridine synthase activity
Y981_RS12200	COG0358	DNA primase activity
Y981_RS12220	COG2264	protein methyltransferase activity
Y981_RS12225	COG0785	Cytochrome C biogenesis protein
Y981_RS12225	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins