locus-tag	class	description
LFE_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
LFE_RS00015	COG0187	DNA topoisomerase II activity
LFE_RS00020	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
LFE_RS00030	COG0602	queuosine metabolic process
LFE_RS00035	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
LFE_RS00040	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
LFE_RS00045	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
LFE_RS00120	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
LFE_RS00140	COG3447	MASE1 domain protein
LFE_RS00140	COG5001	Diguanylate cyclase
LFE_RS00140	COG5002	protein histidine kinase activity
LFE_RS00150	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
LFE_RS00165	COG5000	phosphorelay sensor kinase activity
LFE_RS00170	COG2204	response regulator
LFE_RS00175	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LFE_RS00200	COG0493	'glutamate synthase
LFE_RS00205	COG1013	pyruvate-flavodoxin oxidoreductase activity
LFE_RS00210	COG0674	pyruvate-flavodoxin oxidoreductase activity
LFE_RS00225	COG0149	triose-phosphate isomerase activity
LFE_RS00235	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
LFE_RS00240	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
LFE_RS00255	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
LFE_RS00265	COG0601	transmembrane transport
LFE_RS00270	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LFE_RS00275	COG0546	phosphoglycolate phosphatase activity
LFE_RS00310	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LFE_RS00315	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
LFE_RS00320	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
LFE_RS00325	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
LFE_RS00335	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LFE_RS00420	COG1595	DNA-templated transcription, initiation
LFE_RS00445	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LFE_RS00490	COG2801	Transposase and inactivated derivatives
LFE_RS00515	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LFE_RS00525	COG2022	thiamine diphosphate biosynthetic process
LFE_RS00530	COG0352	thiamine-phosphate diphosphorylase activity
LFE_RS00550	COG1061	Type III restriction enzyme res subunit
LFE_RS00555	COG1573	uracil-dna glycosylase
LFE_RS00560	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
LFE_RS00565	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
LFE_RS00570	COG0291	Belongs to the bacterial ribosomal protein bL35 family
LFE_RS00575	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
LFE_RS00580	COG0072	phenylalanine-tRNA ligase activity
LFE_RS00590	COG4608	Belongs to the ABC transporter superfamily
LFE_RS00600	COG0720	synthase
LFE_RS00655	COG2801	Transposase and inactivated derivatives
LFE_RS00680	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LFE_RS00685	COG3657	addiction module killer protein
LFE_RS00710	COG3657	addiction module killer protein
LFE_RS00715	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LFE_RS00720	COG2207	Transcriptional regulator
LFE_RS00725	COG0667	Aldo Keto reductase
LFE_RS00730	COG1064	alcohol dehydrogenase
LFE_RS00750	COG0477	Major facilitator Superfamily
LFE_RS00795	COG0488	(ABC) transporter
LFE_RS00830	COG0420	3'-5' exonuclease activity
LFE_RS00835	COG4717	serine-type aminopeptidase activity
LFE_RS00840	COG0415	Belongs to the DNA photolyase family
LFE_RS00850	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
LFE_RS00860	COG2078	PFAM AMMECR1 domain protein
LFE_RS00865	COG1355	regulation of microtubule-based process
LFE_RS00885	COG0166	Belongs to the GPI family
LFE_RS00890	COG0261	This protein binds to 23S rRNA in the presence of protein L20
LFE_RS00895	COG0211	Belongs to the bacterial ribosomal protein bL27 family
LFE_RS00900	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
LFE_RS00905	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
LFE_RS00910	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
LFE_RS00915	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
LFE_RS00935	COG1199	ATP-dependent helicase activity
LFE_RS00945	COG0670	Belongs to the BI1 family
LFE_RS00970	COG0237	dephospho-CoA kinase activity
LFE_RS00975	COG1210	Utp--glucose-1-phosphate uridylyltransferase
LFE_RS00980	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
LFE_RS00995	COG2885	chlorophyll binding
LFE_RS01010	COG0557	exoribonuclease II activity
LFE_RS01045	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LFE_RS01075	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
LFE_RS01080	COG3956	TIGRFAM MazG family protein
LFE_RS01115	COG3264	Mechanosensitive ion channel
LFE_RS01115	COG1196	nuclear chromosome segregation
LFE_RS01125	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
LFE_RS01130	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
LFE_RS01135	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
LFE_RS01210	COG3384	dioxygenase
LFE_RS01215	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
LFE_RS01220	COG1028	Short-chain dehydrogenase reductase Sdr
LFE_RS01230	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
LFE_RS01260	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LFE_RS01275	COG1671	Belongs to the UPF0178 family
LFE_RS01280	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
LFE_RS01285	COG0404	The glycine cleavage system catalyzes the degradation of glycine
LFE_RS01290	COG0509	glycine decarboxylation via glycine cleavage system
LFE_RS01295	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LFE_RS01305	COG0095	Lipoate-protein ligase
LFE_RS01340	COG3852	Histidine kinase
LFE_RS01345	COG2204	response regulator
LFE_RS01350	COG1815	bacterial-type flagellum-dependent cell motility
LFE_RS01355	COG1558	bacterial-type flagellum-dependent cell motility
LFE_RS01360	COG1677	Flagellar hook-basal body complex protein FliE
LFE_RS01365	COG1766	The M ring may be actively involved in energy transduction
LFE_RS01370	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
LFE_RS01425	COG1338	Plays a role in the flagellum-specific transport system
LFE_RS01445	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
LFE_RS01450	COG1419	protein localization to endoplasmic reticulum
LFE_RS01450	COG1419	protein localization to endoplasmic reticulum
LFE_RS01460	COG1191	sigma factor activity
LFE_RS01465	COG0745	RESPONSE REGULATOR receiver
LFE_RS01470	COG2198	Histidine kinase
LFE_RS01470	COG0784	Response regulator, receiver
LFE_RS01470	COG0643	Histidine kinase
LFE_RS01475	COG0840	transmembrane signaling receptor activity
LFE_RS01485	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
LFE_RS01490	COG1360	Flagellar Motor Protein
LFE_RS01510	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
LFE_RS01565	COG1116	anion transmembrane transporter activity
LFE_RS01580	COG0758	DNA mediated transformation
LFE_RS01585	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LFE_RS01595	COG4974	Belongs to the 'phage' integrase family
LFE_RS01600	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
LFE_RS01630	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
LFE_RS01640	COG3177	Filamentation induced by cAMP protein fic
LFE_RS01665	COG0848	biopolymer transport protein
LFE_RS01670	COG0811	peptide transport
LFE_RS01680	COG0745	RESPONSE REGULATOR receiver
LFE_RS01735	COG2837	iron assimilation
LFE_RS01755	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
LFE_RS01815	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
LFE_RS01910	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
LFE_RS01915	COG0815	Transfers the fatty acyl group on membrane lipoproteins
LFE_RS01935	COG0301	tRNA thio-modification
LFE_RS01940	COG2329	Antibiotic biosynthesis monooxygenase
LFE_RS01945	COG2255	four-way junction helicase activity
LFE_RS01950	COG0632	four-way junction helicase activity
LFE_RS01955	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
LFE_RS01960	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LFE_RS01970	COG3852	Histidine kinase
LFE_RS01975	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
LFE_RS01980	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LFE_RS02015	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LFE_RS02020	COG0601	transmembrane transport
LFE_RS02040	COG0004	ammonium transporteR
LFE_RS02045	COG0347	Belongs to the P(II) protein family
LFE_RS02050	COG2217	Heavy metal translocating P-type atpase
LFE_RS02070	COG0859	PFAM glycosyl transferase family 9
LFE_RS02075	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
LFE_RS02095	COG0492	ferredoxin-NADP+ reductase activity
LFE_RS02095	COG3118	belongs to the thioredoxin family
LFE_RS02100	COG0308	aminopeptidase N
LFE_RS02110	COG1742	UPF0060 membrane protein
LFE_RS02115	COG0556	nucleotide-excision repair
LFE_RS02125	COG4251	negative regulation of phosphorylation
LFE_RS02130	COG0784	Response regulator, receiver
LFE_RS02190	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
LFE_RS02260	COG1968	undecaprenyl-diphosphatase activity
LFE_RS02270	COG1592	Rubrerythrin
LFE_RS02325	COG0037	tRNA processing
LFE_RS02350	COG0268	Binds directly to 16S ribosomal RNA
LFE_RS02365	COG0495	leucyl-tRNA aminoacylation
LFE_RS02390	COG0521	Mo-molybdopterin cofactor biosynthetic process
LFE_RS02395	COG0315	cyclic pyranopterin monophosphate synthase activity
LFE_RS02405	COG0314	molybdopterin synthase activity
LFE_RS02415	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
LFE_RS02420	COG0347	Belongs to the P(II) protein family
LFE_RS02430	COG2223	nitrite transmembrane transporter activity
LFE_RS02475	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LFE_RS02495	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LFE_RS02510	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LFE_RS02555	COG4796	Type ii and iii secretion system protein
LFE_RS02595	COG0840	transmembrane signaling receptor activity
LFE_RS02600	COG1950	PFAM Membrane protein of
LFE_RS02605	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LFE_RS02610	COG0658	competence protein
LFE_RS02610	COG2333	competence protein COMEC
LFE_RS02640	COG0582	viral genome integration into host DNA
LFE_RS02785	COG0629	single-stranded DNA binding
LFE_RS02820	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
LFE_RS02915	COG4943	cyclic-guanylate-specific phosphodiesterase activity
LFE_RS02985	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LFE_RS03015	COG4974	Belongs to the 'phage' integrase family
LFE_RS03030	COG0840	transmembrane signaling receptor activity
LFE_RS03095	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LFE_RS03170	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
LFE_RS03210	COG0667	Aldo Keto reductase
LFE_RS03240	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LFE_RS03260	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
LFE_RS03270	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LFE_RS03275	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
LFE_RS03290	COG0113	porphobilinogen synthase activity
LFE_RS03305	COG0181	hydroxymethylbilane synthase activity
LFE_RS03310	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
LFE_RS03330	COG0778	Nitroreductase
LFE_RS03335	COG0717	Belongs to the dCTP deaminase family
LFE_RS03340	COG1222	aaa ATPase
LFE_RS03345	COG4122	O-methyltransferase activity
LFE_RS03355	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
LFE_RS03365	COG4122	O-methyltransferase activity
LFE_RS03375	COG0083	homoserine kinase activity
LFE_RS03380	COG3411	Ferredoxin
LFE_RS03435	COG1262	PFAM Formylglycine-generating sulfatase enzyme
LFE_RS03470	COG0494	nUDIX hydrolase
LFE_RS03475	COG2204	response regulator
LFE_RS03485	COG0512	Glutamine amidotransferase of anthranilate synthase
LFE_RS03490	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
LFE_RS03495	COG0134	indole-3-glycerol-phosphate synthase activity
LFE_RS03500	COG0135	phosphoribosylanthranilate isomerase activity
LFE_RS03505	COG0133	tryptophan synthase activity
LFE_RS03510	COG0159	tryptophan synthase activity
LFE_RS03515	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
LFE_RS03520	COG0285	dihydrofolate synthase activity
LFE_RS03525	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
LFE_RS03535	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
LFE_RS03585	COG1666	GTP binding
LFE_RS03590	COG0616	signal peptide processing
LFE_RS03655	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
LFE_RS03660	COG0540	Belongs to the ATCase OTCase family
LFE_RS03665	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LFE_RS03670	COG0505	Belongs to the CarA family
LFE_RS03680	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
LFE_RS03685	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LFE_RS03695	COG0316	Belongs to the HesB IscA family
LFE_RS03725	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
LFE_RS03735	COG0519	Catalyzes the synthesis of GMP from XMP
LFE_RS03735	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LFE_RS03740	COG0517	IMP dehydrogenase activity
LFE_RS03740	COG0516	GMP reductase activity
LFE_RS03775	COG0815	Transfers the fatty acyl group on membrane lipoproteins
LFE_RS03785	COG1793	dna ligase
LFE_RS03795	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
LFE_RS03800	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
LFE_RS03820	COG0481	GTPase activity
LFE_RS03835	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
LFE_RS03840	COG0504	CTP synthase activity
LFE_RS03845	COG2877	3-deoxy-8-phosphooctulonate synthase activity
LFE_RS03860	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
LFE_RS03875	COG2205	protein histidine kinase activity
LFE_RS03875	COG0784	Response regulator, receiver
LFE_RS03875	COG2198	Histidine kinase
LFE_RS03890	COG0730	response to heat
LFE_RS03905	COG0820	rRNA (adenine-C2-)-methyltransferase activity
LFE_RS03925	COG3278	Belongs to the heme-copper respiratory oxidase family
LFE_RS03930	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LFE_RS03940	COG0473	3-isopropylmalate dehydrogenase activity
LFE_RS03950	COG2204	response regulator
LFE_RS03955	COG5002	protein histidine kinase activity
LFE_RS03960	COG3002	Belongs to the UPF0753 family
LFE_RS03965	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
LFE_RS03985	COG0095	Lipoate-protein ligase
LFE_RS03995	COG0438	transferase activity, transferring glycosyl groups
LFE_RS04030	COG0697	spore germination
LFE_RS04035	COG0583	DNA-binding transcription factor activity
LFE_RS04100	COG0628	permease
LFE_RS04105	COG0066	3-isopropylmalate dehydratase activity
LFE_RS04110	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
LFE_RS04145	COG5001	Diguanylate cyclase
LFE_RS04185	COG1104	cysteine desulfurase activity
LFE_RS04195	COG1832	CoA-binding protein
LFE_RS04205	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LFE_RS04215	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
LFE_RS04230	COG1858	cytochrome C peroxidase
LFE_RS04235	COG0450	alkyl hydroperoxide reductase
LFE_RS04245	COG1850	ribulose-bisphosphate carboxylase activity
LFE_RS04250	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
LFE_RS04255	COG0235	Class ii aldolase
LFE_RS04265	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
LFE_RS04270	COG3321	synthase
LFE_RS04270	COG0604	alcohol dehydrogenase
LFE_RS04275	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
LFE_RS04280	COG0837	glucose binding
LFE_RS04290	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
LFE_RS04295	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
LFE_RS04315	COG0740	serine-type endopeptidase activity
LFE_RS04320	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
LFE_RS04345	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
LFE_RS04355	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
LFE_RS04360	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
LFE_RS04365	COG0193	aminoacyl-tRNA hydrolase activity
LFE_RS04370	COG0012	GTP binding
LFE_RS04375	COG0360	Binds together with S18 to 16S ribosomal RNA
LFE_RS04380	COG0629	single-stranded DNA binding
LFE_RS04395	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
LFE_RS04410	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LFE_RS04450	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LFE_RS04465	COG0250	Participates in transcription elongation, termination and antitermination
LFE_RS04470	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
LFE_RS04480	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
LFE_RS04495	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
LFE_RS04500	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
LFE_RS04505	COG0049	tRNA binding
LFE_RS04510	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
LFE_RS04515	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LFE_RS04520	COG0051	transcription antitermination factor activity, RNA binding
LFE_RS04525	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
LFE_RS04530	COG0088	Forms part of the polypeptide exit tunnel
LFE_RS04535	COG0089	rRNA binding
LFE_RS04545	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
LFE_RS04550	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
LFE_RS04555	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
LFE_RS04560	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
LFE_RS04565	COG0255	Belongs to the universal ribosomal protein uL29 family
LFE_RS04575	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
LFE_RS04585	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
LFE_RS04590	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
LFE_RS04595	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
LFE_RS04600	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
LFE_RS04605	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
LFE_RS04610	COG1841	ribosomal large subunit assembly
LFE_RS04615	COG0200	Binds to the 23S rRNA
LFE_RS04620	COG0201	protein transport
LFE_RS04625	COG0563	adenylate kinase activity
LFE_RS04635	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
LFE_RS04640	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
LFE_RS04645	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
LFE_RS04650	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
LFE_RS04655	COG0202	RNA polymerase activity
LFE_RS04660	COG0203	ribosomal protein L17
LFE_RS04680	COG1877	trehalose-phosphatase activity
LFE_RS04685	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
LFE_RS04705	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LFE_RS04715	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
LFE_RS04720	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LFE_RS04730	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
LFE_RS04740	COG1309	transcriptional regulator
LFE_RS04765	COG0583	DNA-binding transcription factor activity
LFE_RS04785	COG1131	(ABC) transporter
LFE_RS04840	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LFE_RS04870	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LFE_RS04875	COG0076	glutamate decarboxylase activity
LFE_RS04880	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LFE_RS04885	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LFE_RS04895	COG0352	thiamine-phosphate diphosphorylase activity
LFE_RS04900	COG0439	Biotin carboxylase
LFE_RS04905	COG0511	ligase activity, forming carbon-carbon bonds
LFE_RS04910	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
LFE_RS04915	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
LFE_RS04935	COG1758	RNA polymerase activity
LFE_RS04945	COG2052	Domain of unknown function (DUF370)
LFE_RS04950	COG1561	YicC-like family, N-terminal region
LFE_RS04985	COG0156	8-amino-7-oxononanoate synthase activity
LFE_RS04990	COG1424	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
LFE_RS04995	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
LFE_RS05000	COG1902	pentaerythritol trinitrate reductase activity
LFE_RS05005	COG1959	2 iron, 2 sulfur cluster binding
LFE_RS05020	COG0751	glycine-tRNA ligase activity
LFE_RS05025	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LFE_RS05025	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LFE_RS05035	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
LFE_RS05045	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
LFE_RS05070	COG1492	cobalamin metabolic process
LFE_RS05075	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
LFE_RS05095	COG0114	fumarate hydratase activity
LFE_RS05105	COG1254	Belongs to the acylphosphatase family
LFE_RS05115	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LFE_RS05125	COG0070	glutamate synthase
LFE_RS05125	COG0069	glutamate synthase activity
LFE_RS05125	COG0067	glutamate synthase
LFE_RS05135	COG3481	metal-dependent phosphohydrolase, HD sub domain
LFE_RS05140	COG0277	FAD linked oxidase domain protein
LFE_RS05145	COG1881	PFAM PEBP family protein
LFE_RS05175	COG0446	pyridine nucleotide-disulphide oxidoreductase
LFE_RS05185	COG1294	oxidase, subunit
LFE_RS05195	COG2204	response regulator
LFE_RS05215	COG0708	Exodeoxyribonuclease III
LFE_RS05225	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
LFE_RS05235	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
LFE_RS05250	COG0302	gtp cyclohydrolase
LFE_RS05270	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
LFE_RS05275	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
LFE_RS05285	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
LFE_RS05290	COG1605	Chorismate mutase
LFE_RS05290	COG0077	Prephenate dehydratase
LFE_RS05295	COG0217	transcriptional regulatory protein
LFE_RS05320	COG1566	PFAM secretion protein HlyD family protein
LFE_RS05345	COG0366	Alpha amylase catalytic
LFE_RS05365	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LFE_RS05375	COG1489	DNA binding
LFE_RS05380	COG1088	dTDP-glucose 4,6-dehydratase activity
LFE_RS05390	COG0105	UTP biosynthetic process
LFE_RS05405	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
LFE_RS05465	COG2026	Addiction module toxin, RelE StbE family
LFE_RS05510	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
LFE_RS05515	COG0840	transmembrane signaling receptor activity
LFE_RS05540	COG0577	efflux transmembrane transporter activity
LFE_RS05595	COG0714	Associated with various cellular activities
LFE_RS05610	COG0653	protein targeting
LFE_RS05630	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LFE_RS05635	COG4974	Belongs to the 'phage' integrase family
LFE_RS05665	COG0297	glycogen (starch) synthase activity
LFE_RS05675	COG0840	transmembrane signaling receptor activity
LFE_RS05680	COG1388	LysM domain
LFE_RS05680	COG3942	CHAP domain
LFE_RS05700	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
LFE_RS05705	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
LFE_RS05775	COG0436	Aminotransferase
LFE_RS05790	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
LFE_RS05800	COG0527	aspartate kinase activity
LFE_RS05805	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LFE_RS05810	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LFE_RS05815	COG0776	regulation of translation
LFE_RS05830	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
LFE_RS05840	COG0215	cysteine-tRNA ligase activity
LFE_RS05845	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LFE_RS05850	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LFE_RS05855	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LFE_RS05855	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
LFE_RS05860	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LFE_RS05860	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LFE_RS05865	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
LFE_RS05885	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
LFE_RS05890	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
LFE_RS05930	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
LFE_RS05935	COG1032	radical SAM domain protein
LFE_RS05945	COG0058	SHG alpha-glucan phosphorylase activity
LFE_RS05950	COG0300	oxidoreductase activity
LFE_RS05975	COG0330	HflC and HflK could
LFE_RS05985	COG0157	Belongs to the NadC ModD family
LFE_RS06040	COG5002	protein histidine kinase activity
LFE_RS06060	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
LFE_RS06065	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
LFE_RS06075	COG2205	protein histidine kinase activity
LFE_RS06110	COG1994	Peptidase M50
LFE_RS06115	COG0180	Tryptophanyl-tRNA synthetase
LFE_RS06190	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
LFE_RS06195	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LFE_RS06200	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
LFE_RS06205	COG0305	Participates in initiation and elongation during chromosome replication
LFE_RS06210	COG4795	General secretion pathway protein
LFE_RS06255	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LFE_RS06260	COG1127	ABC transporter
LFE_RS06295	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LFE_RS06300	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LFE_RS06310	COG0343	queuine tRNA-ribosyltransferase activity
LFE_RS06315	COG0018	arginyl-trna synthetase
LFE_RS06335	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
LFE_RS06340	COG0542	response to heat
LFE_RS06350	COG2308	Evidence 4 Homologs of previously reported genes of
LFE_RS06375	COG0412	Dienelactone hydrolase
LFE_RS06400	COG3706	GGDEF domain
LFE_RS06405	COG0640	Transcriptional regulator
LFE_RS06420	COG2226	methyltransferase
LFE_RS06445	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LFE_RS06445	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LFE_RS06455	COG0477	Major facilitator Superfamily
LFE_RS06520	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
LFE_RS06525	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
LFE_RS06530	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
LFE_RS06555	COG0811	peptide transport
LFE_RS06610	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LFE_RS06615	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LFE_RS06695	COG0028	Belongs to the TPP enzyme family
LFE_RS06830	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
LFE_RS06840	COG2801	Transposase and inactivated derivatives
LFE_RS06935	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
LFE_RS06965	COG0579	oxidoreductase
LFE_RS07005	COG0583	DNA-binding transcription factor activity
LFE_RS07010	COG0697	spore germination
LFE_RS07015	COG3511	phospholipase C
LFE_RS07035	COG2226	methyltransferase
LFE_RS07040	COG1595	DNA-templated transcription, initiation
LFE_RS07045	COG3437	response regulator, receiver
LFE_RS07050	COG0784	Response regulator, receiver
LFE_RS07065	COG2226	methyltransferase
LFE_RS07075	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LFE_RS07090	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
LFE_RS07095	COG0463	Glycosyl transferase, family 2
LFE_RS07100	COG0463	Glycosyl transferase, family 2
LFE_RS07105	COG0513	Belongs to the DEAD box helicase family
LFE_RS07160	COG2856	Zn peptidase
LFE_RS07205	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
LFE_RS07215	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
LFE_RS07220	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
LFE_RS07230	COG1136	(ABC) transporter
LFE_RS07275	COG0151	Belongs to the GarS family
LFE_RS07290	COG0463	Glycosyl transferase, family 2
LFE_RS07305	COG0671	phosphoesterase, PA-phosphatase related
LFE_RS07310	COG1045	serine acetyltransferase
LFE_RS07315	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
LFE_RS07320	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
LFE_RS07325	COG4956	integral membrane protein (PIN domain superfamily)
LFE_RS07335	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
LFE_RS07345	COG1597	lipid kinase activity
LFE_RS07355	COG0438	transferase activity, transferring glycosyl groups
LFE_RS07370	COG0859	PFAM glycosyl transferase family 9
LFE_RS07375	COG2835	tetraacyldisaccharide 4'-kinase activity
LFE_RS07380	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
LFE_RS07385	COG0859	PFAM glycosyl transferase family 9
LFE_RS07390	COG1216	Glycosyl transferase, family 2
LFE_RS07405	COG0859	PFAM glycosyl transferase family 9
LFE_RS07410	COG0463	Glycosyl transferase, family 2
LFE_RS07440	COG0859	PFAM glycosyl transferase family 9
LFE_RS07445	COG1560	Kdo2-lipid A biosynthetic process
LFE_RS07450	COG1663	tetraacyldisaccharide 4'-kinase activity
LFE_RS07460	COG1132	(ABC) transporter
LFE_RS07465	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LFE_RS07470	COG0673	inositol 2-dehydrogenase activity
LFE_RS07490	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LFE_RS07515	COG1797	cobyrinic acid a,c-diamide synthase activity
LFE_RS07535	COG0667	Aldo Keto reductase
LFE_RS07555	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
LFE_RS07580	COG0484	heat shock protein binding
LFE_RS07585	COG0443	Heat shock 70 kDa protein
LFE_RS07590	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
LFE_RS07595	COG1420	regulation of RNA biosynthetic process
LFE_RS07600	COG2814	Major facilitator Superfamily
LFE_RS07605	COG1566	PFAM secretion protein HlyD family protein
LFE_RS07615	COG2814	Major facilitator Superfamily
LFE_RS07630	COG1309	transcriptional regulator
LFE_RS07640	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
LFE_RS07655	COG3707	response regulator
LFE_RS07660	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
LFE_RS07665	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
LFE_RS07670	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
LFE_RS07680	COG1660	Displays ATPase and GTPase activities
LFE_RS07685	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
LFE_RS07695	COG1137	ATPase activity
LFE_RS07710	COG0039	L-malate dehydrogenase activity
LFE_RS07755	COG0157	Belongs to the NadC ModD family
LFE_RS07760	COG0525	valine-tRNA ligase activity
LFE_RS07765	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
LFE_RS07770	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
LFE_RS07775	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LFE_RS07785	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
LFE_RS07805	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
LFE_RS07810	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
LFE_RS07815	COG1982	Orn Lys Arg decarboxylase major
LFE_RS07820	COG1615	UPF0182 protein
LFE_RS07825	COG0497	DNA recombination
LFE_RS07830	COG3118	belongs to the thioredoxin family
LFE_RS07835	COG0459	protein refolding
LFE_RS07840	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
LFE_RS07845	COG0793	Belongs to the peptidase S41A family
LFE_RS07865	COG0335	large ribosomal subunit rRNA binding
LFE_RS07870	COG0336	Belongs to the RNA methyltransferase TrmD family
LFE_RS07880	COG0228	four-way junction DNA binding
LFE_RS07885	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
LFE_RS07890	COG0776	regulation of translation
LFE_RS07895	COG0616	signal peptide processing
LFE_RS07900	COG2183	response to ionizing radiation
LFE_RS07900	COG0539	negative regulation of cytoplasmic translation
LFE_RS07970	COG0617	tRNA 3'-terminal CCA addition
LFE_RS07990	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
LFE_RS08005	COG0251	oxidation-reduction process
LFE_RS08050	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
LFE_RS08060	COG1573	uracil-dna glycosylase
LFE_RS08065	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
LFE_RS08065	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
LFE_RS08075	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
LFE_RS08080	COG0612	Peptidase, M16
LFE_RS08090	COG3344	reverse transcriptase
LFE_RS08130	COG1185	polyribonucleotide nucleotidyltransferase activity
LFE_RS08140	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
LFE_RS08145	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
LFE_RS08150	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
LFE_RS08155	COG0195	Participates in both transcription termination and antitermination
LFE_RS08160	COG0779	Required for maturation of 30S ribosomal subunits
LFE_RS08170	COG0784	Response regulator, receiver
LFE_RS08170	COG0835	chemotaxis
LFE_RS08220	COG1335	isochorismatase
LFE_RS08235	COG1942	4-Oxalocrotonate Tautomerase
LFE_RS08285	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LFE_RS08295	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LFE_RS08300	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LFE_RS08360	COG1673	EVE domain
LFE_RS08375	COG0477	Major facilitator Superfamily
LFE_RS08395	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
LFE_RS08400	COG0589	response to stress
LFE_RS08415	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
LFE_RS08420	COG0552	protein localization to endoplasmic reticulum
LFE_RS08425	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
LFE_RS08435	COG0322	excinuclease ABC activity
LFE_RS08455	COG1410	methionine synthase
LFE_RS08455	COG0646	methionine synthase
LFE_RS08470	COG1217	gtp-binding protein TYPA
LFE_RS08490	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
LFE_RS08495	COG0300	oxidoreductase activity
LFE_RS08515	COG1959	2 iron, 2 sulfur cluster binding
LFE_RS08535	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
LFE_RS08540	COG1074	ATP-dependent DNA helicase activity
LFE_RS08545	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
LFE_RS08575	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
LFE_RS08575	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
LFE_RS08595	COG2329	Antibiotic biosynthesis monooxygenase
LFE_RS08620	COG4796	Type ii and iii secretion system protein
LFE_RS08630	COG1459	type II secretion system
LFE_RS08700	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LFE_RS08705	COG1007	ATP synthesis coupled electron transport
LFE_RS08720	COG0713	ATP synthesis coupled electron transport
LFE_RS08725	COG0839	Belongs to the complex I subunit 6 family
LFE_RS08735	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
LFE_RS08760	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LFE_RS08765	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LFE_RS08770	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LFE_RS08775	COG0653	protein targeting
LFE_RS08800	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
LFE_RS08810	COG1722	exodeoxyribonuclease VII activity
LFE_RS08825	COG1418	mRNA catabolic process
LFE_RS08855	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
LFE_RS08860	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
LFE_RS08865	COG1674	ftsk spoiiie
LFE_RS08875	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LFE_RS08885	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
LFE_RS08900	COG2081	HI0933 family
LFE_RS08905	COG1408	metallophosphoesterase
LFE_RS08915	COG1127	ABC transporter
LFE_RS08920	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LFE_RS08925	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
LFE_RS08935	COG5002	protein histidine kinase activity
LFE_RS08950	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
LFE_RS08960	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
LFE_RS08970	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
LFE_RS08975	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
LFE_RS08980	COG2022	thiamine diphosphate biosynthetic process
LFE_RS08980	COG2104	thiamine diphosphate biosynthetic process
LFE_RS08985	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
LFE_RS08990	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
LFE_RS08995	COG0538	isocitrate dehydrogenase activity
LFE_RS09005	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
LFE_RS09015	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LFE_RS09020	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
LFE_RS09030	COG2801	Transposase and inactivated derivatives
LFE_RS09070	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LFE_RS09075	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
LFE_RS09080	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LFE_RS09095	COG1657	PFAM Prenyltransferase squalene oxidase
LFE_RS09120	COG1131	(ABC) transporter
LFE_RS09125	COG0842	Transport permease protein
LFE_RS09130	COG0842	Transport permease protein
LFE_RS09140	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
LFE_RS09145	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
LFE_RS09150	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LFE_RS09170	COG0762	integral membrane protein
LFE_RS09175	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
LFE_RS09180	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
LFE_RS09190	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
LFE_RS09210	COG0812	UDP-N-acetylmuramate dehydrogenase activity
LFE_RS09215	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LFE_RS09220	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
LFE_RS09225	COG0772	Belongs to the SEDS family
LFE_RS09230	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
LFE_RS09235	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LFE_RS09240	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LFE_RS09245	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
LFE_RS09250	COG0768	penicillin binding
LFE_RS09260	COG0275	rRNA processing
LFE_RS09265	COG2001	Belongs to the MraZ family
LFE_RS09280	COG0450	alkyl hydroperoxide reductase
LFE_RS09285	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
LFE_RS09290	COG0045	succinate-CoA ligase (ADP-forming) activity
LFE_RS09295	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
LFE_RS09310	COG0372	Belongs to the citrate synthase family
LFE_RS09320	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
LFE_RS09325	COG0045	succinate-CoA ligase (ADP-forming) activity
LFE_RS09335	COG2200	EAL domain
LFE_RS09340	COG2200	EAL domain
LFE_RS09345	COG1073	alpha beta
LFE_RS09345	COG2226	methyltransferase
LFE_RS09350	COG2326	polyphosphate kinase activity
LFE_RS09355	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
LFE_RS09360	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
LFE_RS09365	COG0058	SHG alpha-glucan phosphorylase activity
LFE_RS09390	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
LFE_RS09395	COG0129	dihydroxy-acid dehydratase activity
LFE_RS09415	COG1064	alcohol dehydrogenase
LFE_RS09420	COG2046	Belongs to the sulfate adenylyltransferase family
LFE_RS09435	COG0009	L-threonylcarbamoyladenylate synthase
LFE_RS09440	COG3604	Transcriptional regulator
LFE_RS09450	COG0129	dihydroxy-acid dehydratase activity
LFE_RS09475	COG3002	Belongs to the UPF0753 family
LFE_RS09480	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
LFE_RS09490	COG5609	conserved protein (DUF2294)
LFE_RS09495	COG5609	conserved protein (DUF2294)
LFE_RS09500	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
LFE_RS09515	COG1253	flavin adenine dinucleotide binding
LFE_RS09530	COG1959	2 iron, 2 sulfur cluster binding
LFE_RS09540	COG0822	iron-sulfur transferase activity
LFE_RS09545	COG0316	Belongs to the HesB IscA family
LFE_RS09550	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
LFE_RS09565	COG2975	iron-sulfur cluster assembly
LFE_RS09575	COG0489	protein tyrosine kinase activity
LFE_RS09590	COG0101	tRNA pseudouridine synthase activity
LFE_RS09605	COG0840	transmembrane signaling receptor activity
LFE_RS09615	COG0655	NAD(P)H dehydrogenase (quinone) activity
LFE_RS09625	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
LFE_RS09665	COG0612	Peptidase, M16
LFE_RS09670	COG0612	Peptidase, M16
LFE_RS09690	COG0148	phosphopyruvate hydratase activity
LFE_RS09705	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LFE_RS09710	COG0154	amidase activity
LFE_RS09715	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
LFE_RS09720	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LFE_RS09725	COG0210	DNA helicase
LFE_RS09735	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
LFE_RS09745	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LFE_RS09745	COG1017	nitric oxide dioxygenase activity
LFE_RS09755	COG3189	MarR family transcriptional regulator
LFE_RS09765	COG1902	pentaerythritol trinitrate reductase activity
LFE_RS09775	COG2259	Doxx family
LFE_RS09780	COG1846	Transcriptional regulator
LFE_RS09785	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
LFE_RS09790	COG0470	DNA polymerase III
LFE_RS09795	COG1774	PSP1 C-terminal conserved region
LFE_RS09800	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LFE_RS09800	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LFE_RS09805	COG0084	hydrolase, TatD family'
LFE_RS09815	COG0531	amino acid
LFE_RS09840	COG0531	amino acid
LFE_RS09845	COG1252	NADH dehydrogenase
LFE_RS09860	COG1160	GTP binding
LFE_RS09865	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LFE_RS09865	COG0574	Belongs to the PEP-utilizing enzyme family
LFE_RS09870	COG2204	response regulator
LFE_RS09885	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
LFE_RS09895	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LFE_RS09925	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
LFE_RS09930	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
LFE_RS09950	COG0571	ribonuclease III activity
LFE_RS09955	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LFE_RS09965	COG1028	Short-chain dehydrogenase reductase Sdr
LFE_RS09970	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
LFE_RS09975	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LFE_RS09980	COG0416	fatty acid biosynthetic process
LFE_RS09985	COG0333	Belongs to the bacterial ribosomal protein bL32 family
LFE_RS09995	COG0442	prolyl-tRNA aminoacylation
LFE_RS10000	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
LFE_RS10005	COG0750	zinc metalloprotease
LFE_RS10020	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
LFE_RS10030	COG2759	Belongs to the formate--tetrahydrofolate ligase family
LFE_RS10035	COG0805	protein transport
LFE_RS10055	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
LFE_RS10070	COG0312	modulator of DNA gyrase
LFE_RS10075	COG0312	modulator of DNA gyrase
LFE_RS10090	COG1233	COG1233 Phytoene dehydrogenase and related
LFE_RS10105	COG1402	creatininase
LFE_RS10190	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
LFE_RS10210	COG1741	Belongs to the pirin family
LFE_RS10275	COG0588	phosphoglycerate mutase activity
LFE_RS10285	COG0513	Belongs to the DEAD box helicase family
LFE_RS10290	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
LFE_RS10295	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
LFE_RS10300	COG1472	Belongs to the glycosyl hydrolase 3 family
LFE_RS10305	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
LFE_RS10310	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
LFE_RS10315	COG0488	(ABC) transporter
LFE_RS10345	COG0328	RNA-DNA hybrid ribonuclease activity
LFE_RS10360	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LFE_RS10365	COG0358	DNA primase activity
LFE_RS10370	COG1610	YqeY-like protein
LFE_RS10390	COG0537	adenosine 5'-monophosphoramidase activity
LFE_RS10395	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
LFE_RS10395	COG0140	phosphoribosyl-ATP diphosphatase activity
LFE_RS10400	COG0107	imidazoleglycerol-phosphate synthase activity
LFE_RS10410	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
LFE_RS10415	COG0131	Imidazoleglycerol-phosphate dehydratase
LFE_RS10430	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
LFE_RS10440	COG2890	protein-(glutamine-N5) methyltransferase activity
LFE_RS10445	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
LFE_RS10450	COG0254	rRNA binding
LFE_RS10455	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
LFE_RS10475	COG0123	including yeast histone deacetylase and acetoin utilization protein
LFE_RS10490	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
LFE_RS10505	COG1012	belongs to the aldehyde dehydrogenase family
LFE_RS10515	COG2203	Gaf domain
LFE_RS10515	COG2199	diguanylate cyclase activity
LFE_RS10525	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
LFE_RS10530	COG0704	Plays a role in the regulation of phosphate uptake
LFE_RS10535	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
LFE_RS10540	COG0573	inorganic phosphate transmembrane transporter activity
LFE_RS10555	COG0745	RESPONSE REGULATOR receiver
LFE_RS10575	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
LFE_RS10580	COG4493	Belongs to the UPF0637 family
LFE_RS10595	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
LFE_RS10600	COG2003	Belongs to the UPF0758 family
LFE_RS10630	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LFE_RS10645	COG2801	Transposase and inactivated derivatives
LFE_RS10655	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LFE_RS10660	COG1136	(ABC) transporter
LFE_RS10660	COG0577	efflux transmembrane transporter activity
LFE_RS10665	COG0577	efflux transmembrane transporter activity
LFE_RS10665	COG1136	(ABC) transporter
LFE_RS10670	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
LFE_RS10710	COG0859	PFAM glycosyl transferase family 9
LFE_RS10750	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
LFE_RS10755	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
LFE_RS10770	COG1256	bacterial-type flagellum assembly
LFE_RS10785	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
LFE_RS10795	COG1706	bacterial-type flagellum-dependent cell motility
LFE_RS10815	COG4786	Flagellar basal body rod
LFE_RS10825	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LFE_RS10830	COG0179	Fumarylacetoacetate (FAA) hydrolase
LFE_RS10850	COG0019	diaminopimelate decarboxylase activity
LFE_RS10860	COG0165	Argininosuccinate lyase
LFE_RS10865	COG0137	argininosuccinate synthase activity
LFE_RS10870	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
LFE_RS10875	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LFE_RS10885	COG2814	Major facilitator Superfamily
LFE_RS10945	COG0248	Ppx GppA phosphatase
LFE_RS10955	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
LFE_RS10960	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
LFE_RS10975	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LFE_RS10980	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
LFE_RS10985	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
LFE_RS11000	COG0785	Cytochrome C biogenesis protein
LFE_RS11010	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LFE_RS11015	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LFE_RS11020	COG1333	cytochrome c biogenesis protein
LFE_RS11035	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LFE_RS11040	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LFE_RS11045	COG0233	cytoplasmic translational termination
LFE_RS11050	COG0528	UMP kinase activity
LFE_RS11060	COG0052	Belongs to the universal ribosomal protein uS2 family
LFE_RS11065	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
LFE_RS11070	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
LFE_RS11075	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
LFE_RS11080	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
LFE_RS11085	COG1032	radical SAM domain protein
LFE_RS11090	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
LFE_RS11110	COG1530	ribonuclease E activity
LFE_RS11115	COG0772	Belongs to the SEDS family
LFE_RS11120	COG0768	penicillin binding
LFE_RS11135	COG1077	Cell shape determining protein MreB Mrl
LFE_RS11145	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
LFE_RS11155	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
LFE_RS11160	COG0242	peptide deformylase activity
LFE_RS11170	COG0400	carboxylic ester hydrolase activity
LFE_RS11175	COG1331	Highly conserved protein containing a thioredoxin domain
LFE_RS11180	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
LFE_RS11205	COG3621	Patatin-like phospholipase
LFE_RS11210	COG1830	Aldolase
LFE_RS11245	COG3002	Belongs to the UPF0753 family
LFE_RS11285	COG2204	response regulator
LFE_RS11290	COG0354	folic acid binding
LFE_RS11300	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LFE_RS11320	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
LFE_RS11330	COG1449	Belongs to the glycosyl hydrolase 57 family
LFE_RS11345	COG1543	Belongs to the glycosyl hydrolase 57 family
LFE_RS11420	COG0006	proline dipeptidase activity
LFE_RS11435	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LFE_RS11450	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
LFE_RS11525	COG0438	transferase activity, transferring glycosyl groups
LFE_RS11570	COG0726	polysaccharide deacetylase
LFE_RS11575	COG0438	transferase activity, transferring glycosyl groups
LFE_RS11580	COG1215	transferase activity, transferring glycosyl groups
LFE_RS11595	COG5002	protein histidine kinase activity
LFE_RS11610	COG2204	response regulator
LFE_RS11620	COG1216	Glycosyl transferase, family 2
LFE_RS11625	COG1215	transferase activity, transferring glycosyl groups
LFE_RS11640	COG1132	(ABC) transporter
LFE_RS11645	COG1216	Glycosyl transferase, family 2
LFE_RS11655	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
LFE_RS11670	COG2801	Transposase and inactivated derivatives
LFE_RS11805	COG2814	Major facilitator Superfamily
LFE_RS11815	COG2084	Dehydrogenase
LFE_RS11845	COG2204	response regulator
LFE_RS11850	COG0784	Response regulator, receiver
LFE_RS11865	COG1752	Esterase of the alpha-beta hydrolase superfamily
LFE_RS11870	COG1024	Enoyl-CoA hydratase
LFE_RS11900	COG0542	response to heat
LFE_RS11910	COG3258	Cytochrome c
LFE_RS11935	COG0484	heat shock protein binding
LFE_RS11940	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
LFE_RS11950	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LFE_RS11970	COG1970	mechanosensitive ion channel activity
LFE_RS12000	COG1013	pyruvate-flavodoxin oxidoreductase activity
LFE_RS12035	COG0674	pyruvate-flavodoxin oxidoreductase activity
LFE_RS12035	COG1013	pyruvate-flavodoxin oxidoreductase activity
LFE_RS12035	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
LFE_RS12035	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
LFE_RS12045	COG0484	heat shock protein binding
LFE_RS12055	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
LFE_RS12060	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
LFE_RS12065	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
LFE_RS12065	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
LFE_RS12080	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LFE_RS12085	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LFE_RS12090	COG0218	Necessary for normal cell division and for the maintenance of normal septation
LFE_RS12140	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
LFE_RS12165	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
LFE_RS12170	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
LFE_RS12180	COG0564	pseudouridine synthase activity
LFE_RS12190	COG0142	geranyltranstransferase activity
LFE_RS12205	COG0483	inositol monophosphate 1-phosphatase activity
LFE_RS12215	COG1892	Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four- carbon dicarboxylic acid source for the tricarboxylic acid cycle
LFE_RS12225	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
LFE_RS12245	COG0425	Belongs to the sulfur carrier protein TusA family
LFE_RS12250	COG0571	ribonuclease III activity
LFE_RS12255	COG2176	DNA-directed DNA polymerase activity
LFE_RS12270	COG1475	DNA binding
LFE_RS12275	COG1192	Involved in chromosome partitioning
LFE_RS12285	COG0445	tRNA wobble uridine modification
LFE_RS12290	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
LFE_RS12295	COG0706	membrane insertase activity
LFE_RS12300	COG0594	ribonuclease P activity
LFE_RS12305	COG0359	binds to the 23S rRNA
LFE_RS12330	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
LFE_RS12335	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
LFE_RS12340	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
LFE_RS12345	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
LFE_RS12350	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
LFE_RS12405	COG5554	nitrogen fixation
LFE_RS12415	COG5554	nitrogen fixation
LFE_RS12430	COG4231	catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates
LFE_RS12440	COG0347	Belongs to the P(II) protein family
LFE_RS12450	COG3707	response regulator
LFE_RS12460	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LFE_RS12465	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
LFE_RS12495	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
LFE_RS12520	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
LFE_RS12525	COG0375	protein maturation
LFE_RS12535	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
LFE_RS12565	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
LFE_RS12585	COG2095	MarC family integral membrane protein
LFE_RS12625	COG0284	orotidine-5'-phosphate decarboxylase activity
LFE_RS12640	COG0651	ATP synthesis coupled electron transport
LFE_RS12655	COG0651	ATP synthesis coupled electron transport
LFE_RS12660	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
LFE_RS12660	COG3261	NADH dehydrogenase
LFE_RS12665	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LFE_RS12685	COG1850	ribulose-bisphosphate carboxylase activity
LFE_RS12700	COG0788	formyltetrahydrofolate deformylase activity
LFE_RS12705	COG0346	lactoylglutathione lyase activity
LFE_RS12720	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
LFE_RS12725	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
LFE_RS12730	COG0473	3-isopropylmalate dehydrogenase activity
LFE_RS12735	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LFE_RS12740	COG1183	phosphatidylcholine synthase activity
LFE_RS12750	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
LFE_RS12755	COG0440	acetolactate synthase activity
LFE_RS12760	COG0028	Belongs to the TPP enzyme family
LFE_RS12775	COG1648	precorrin-2 dehydrogenase activity
LFE_RS12775	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LFE_RS12780	COG0739	heme binding
LFE_RS12790	COG3447	MASE1 domain protein
LFE_RS12790	COG5002	protein histidine kinase activity
LFE_RS12790	COG5001	Diguanylate cyclase
LFE_RS12825	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
LFE_RS12830	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
LFE_RS12885	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LFE_RS12940	COG2199	diguanylate cyclase activity
LFE_RS12940	COG2203	Gaf domain
LFE_RS12945	COG3300	MHYT domain
LFE_RS12945	COG5001	Diguanylate cyclase
LFE_RS12950	COG2003	Belongs to the UPF0758 family
LFE_RS12965	COG0802	atpase or kinase
LFE_RS12980	COG0739	heme binding
LFE_RS12985	COG0671	phosphoesterase, PA-phosphatase related
LFE_RS13005	COG0363	glucosamine-6-phosphate deaminase activity
LFE_RS13015	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LFE_RS13030	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
LFE_RS13035	COG1959	2 iron, 2 sulfur cluster binding
LFE_RS13045	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LFE_RS13065	COG0860	N-Acetylmuramoyl-L-alanine amidase
LFE_RS13075	COG2084	Dehydrogenase
LFE_RS13120	COG3344	reverse transcriptase
LFE_RS13150	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
LFE_RS13150	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
LFE_RS13155	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
LFE_RS13165	COG2197	response regulator
LFE_RS13180	COG1381	Involved in DNA repair and RecF pathway recombination
LFE_RS13185	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
LFE_RS13190	COG0739	heme binding
LFE_RS13195	COG1570	exodeoxyribonuclease VII activity
LFE_RS13225	COG4589	Belongs to the CDS family
LFE_RS13235	COG1214	PFAM Peptidase M22, glycoprotease
LFE_RS13240	COG1611	Belongs to the LOG family
LFE_RS13245	COG1619	proteins homologs of microcin C7 resistance protein MccF
LFE_RS13250	COG0546	phosphoglycolate phosphatase activity
LFE_RS13260	COG0739	heme binding
LFE_RS13260	COG0741	lytic transglycosylase activity
LFE_RS13260	COG1196	nuclear chromosome segregation
LFE_RS13280	COG3300	MHYT domain
LFE_RS13280	COG5001	Diguanylate cyclase
LFE_RS13305	COG2197	response regulator
LFE_RS13330	COG4251	negative regulation of phosphorylation
LFE_RS13335	COG2205	protein histidine kinase activity
LFE_RS13335	COG2198	Histidine kinase
LFE_RS13335	COG0784	Response regulator, receiver
LFE_RS13340	COG3300	MHYT domain
LFE_RS13340	COG5001	Diguanylate cyclase
LFE_RS13360	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
LFE_RS13365	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LFE_RS13375	COG0357	Ribosomal RNA small subunit methyltransferase G
LFE_RS13380	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
LFE_RS13390	COG2264	protein methyltransferase activity