locus-tag	class	description
LEBU_RS00050	COG0445	tRNA wobble uridine modification
LEBU_RS00060	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LEBU_RS00065	COG4605	iron ion homeostasis
LEBU_RS00070	COG4604	ABC transporter, ATP-binding protein
LEBU_RS00075	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LEBU_RS00080	COG0534	Mate efflux family protein
LEBU_RS00085	COG0564	pseudouridine synthase activity
LEBU_RS00090	COG0534	Mate efflux family protein
LEBU_RS00115	COG0601	transmembrane transport
LEBU_RS00120	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LEBU_RS00130	COG0444	Belongs to the ABC transporter superfamily
LEBU_RS00135	COG4608	Belongs to the ABC transporter superfamily
LEBU_RS00145	COG0181	hydroxymethylbilane synthase activity
LEBU_RS00150	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
LEBU_RS00180	COG3335	DDE superfamily endonuclease
LEBU_RS00190	COG4166	transmembrane transport
LEBU_RS00200	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LEBU_RS00210	COG1492	cobalamin metabolic process
LEBU_RS00240	COG0789	Transcriptional regulator
LEBU_RS00245	COG4221	oxidoreductase activity
LEBU_RS00260	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
LEBU_RS00265	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
LEBU_RS00270	COG0747	negative chemotaxis
LEBU_RS00275	COG0601	transmembrane transport
LEBU_RS00280	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LEBU_RS00285	COG0444	Belongs to the ABC transporter superfamily
LEBU_RS00305	COG3192	ethanolamine utilization protein
LEBU_RS00310	COG4816	utilization protein
LEBU_RS00315	COG4302	ethanolamine ammonia-lyase activity
LEBU_RS00320	COG4303	Ethanolamine ammonia lyase large subunit
LEBU_RS00325	COG4819	ethanolamine utilization protein
LEBU_RS00335	COG2197	response regulator
LEBU_RS00350	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
LEBU_RS00360	COG4869	propanediol catabolic process
LEBU_RS00370	COG1454	alcohol dehydrogenase
LEBU_RS00370	COG1012	belongs to the aldehyde dehydrogenase family
LEBU_RS00380	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
LEBU_RS00405	COG0310	cobalt ion transport
LEBU_RS00410	COG4608	Belongs to the ABC transporter superfamily
LEBU_RS00420	COG4115	mRNA cleavage
LEBU_RS00430	COG1733	regulation of RNA biosynthetic process
LEBU_RS00450	COG0310	cobalt ion transport
LEBU_RS00470	COG1797	cobyrinic acid a,c-diamide synthase activity
LEBU_RS00480	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
LEBU_RS00485	COG1373	ATPase (AAA superfamily
LEBU_RS00565	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
LEBU_RS00580	COG2226	methyltransferase
LEBU_RS00595	COG0445	tRNA wobble uridine modification
LEBU_RS00600	COG0357	Ribosomal RNA small subunit methyltransferase G
LEBU_RS00635	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
LEBU_RS00640	COG1045	serine acetyltransferase
LEBU_RS00645	COG0716	FMN binding
LEBU_RS00650	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
LEBU_RS00650	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
LEBU_RS00660	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
LEBU_RS00685	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
LEBU_RS00700	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
LEBU_RS00705	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
LEBU_RS00735	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
LEBU_RS00795	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
LEBU_RS00800	COG0670	Belongs to the BI1 family
LEBU_RS00815	COG0227	Belongs to the bacterial ribosomal protein bL28 family
LEBU_RS00830	COG0745	RESPONSE REGULATOR receiver
LEBU_RS00835	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
LEBU_RS00845	COG0242	peptide deformylase activity
LEBU_RS00850	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
LEBU_RS00855	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
LEBU_RS00860	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
LEBU_RS00880	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LEBU_RS00930	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
LEBU_RS00935	COG1737	Transcriptional regulator
LEBU_RS00935	COG0837	glucose binding
LEBU_RS00940	COG2723	6-phospho-beta-galactosidase activity
LEBU_RS00955	COG0346	lactoylglutathione lyase activity
LEBU_RS00980	COG3335	DDE superfamily endonuclease
LEBU_RS01015	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LEBU_RS01020	COG2723	6-phospho-beta-galactosidase activity
LEBU_RS01030	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LEBU_RS01035	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LEBU_RS01040	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
LEBU_RS01045	COG0772	Belongs to the SEDS family
LEBU_RS01050	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
LEBU_RS01055	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LEBU_RS01060	COG0812	UDP-N-acetylmuramate dehydrogenase activity
LEBU_RS01065	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
LEBU_RS01070	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
LEBU_RS01075	COG0360	Binds together with S18 to 16S ribosomal RNA
LEBU_RS01080	COG0629	single-stranded DNA binding
LEBU_RS01085	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
LEBU_RS01110	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
LEBU_RS01130	COG0488	(ABC) transporter
LEBU_RS01160	COG0671	phosphoesterase, PA-phosphatase related
LEBU_RS01165	COG3042	response to heat
LEBU_RS01170	COG1966	Carbon starvation protein
LEBU_RS01185	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
LEBU_RS01190	COG0049	tRNA binding
LEBU_RS01195	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
LEBU_RS01200	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LEBU_RS01205	COG0051	transcription antitermination factor activity, RNA binding
LEBU_RS01210	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
LEBU_RS01215	COG0088	Forms part of the polypeptide exit tunnel
LEBU_RS01220	COG0089	rRNA binding
LEBU_RS01225	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
LEBU_RS01230	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
LEBU_RS01235	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
LEBU_RS01240	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
LEBU_RS01245	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
LEBU_RS01255	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
LEBU_RS01260	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
LEBU_RS01270	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
LEBU_RS01275	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
LEBU_RS01280	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
LEBU_RS01285	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
LEBU_RS01290	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
LEBU_RS01295	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
LEBU_RS01300	COG1841	ribosomal large subunit assembly
LEBU_RS01305	COG0200	Binds to the 23S rRNA
LEBU_RS01310	COG0201	protein transport
LEBU_RS01335	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
LEBU_RS01380	COG0406	alpha-ribazole phosphatase activity
LEBU_RS01395	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
LEBU_RS01400	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
LEBU_RS01430	COG0450	alkyl hydroperoxide reductase
LEBU_RS01465	COG1032	radical SAM domain protein
LEBU_RS01470	COG1032	radical SAM domain protein
LEBU_RS01475	COG1032	radical SAM domain protein
LEBU_RS01480	COG1032	radical SAM domain protein
LEBU_RS01500	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
LEBU_RS01505	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LEBU_RS01515	COG0860	N-Acetylmuramoyl-L-alanine amidase
LEBU_RS01525	COG0126	phosphoglycerate kinase activity
LEBU_RS01555	COG1122	ATPase activity
LEBU_RS01560	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
LEBU_RS01570	COG3700	Belongs to the class B bacterial acid phosphatase family
LEBU_RS01585	COG1309	transcriptional regulator
LEBU_RS01595	COG1566	PFAM secretion protein HlyD family protein
LEBU_RS01600	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LEBU_RS01610	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
LEBU_RS01615	COG2972	Histidine kinase
LEBU_RS01620	COG0745	RESPONSE REGULATOR receiver
LEBU_RS01625	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LEBU_RS01630	COG0785	Cytochrome C biogenesis protein
LEBU_RS01635	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LEBU_RS01635	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LEBU_RS01650	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
LEBU_RS01650	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
LEBU_RS01655	COG0802	atpase or kinase
LEBU_RS01660	COG1214	PFAM Peptidase M22, glycoprotease
LEBU_RS01665	COG0552	protein localization to endoplasmic reticulum
LEBU_RS01670	COG0280	phosphate acetyltransferase
LEBU_RS01675	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
LEBU_RS01685	COG4399	Belongs to the UPF0754 family
LEBU_RS01690	COG2255	four-way junction helicase activity
LEBU_RS01700	COG0799	negative regulation of ribosome biogenesis
LEBU_RS01705	COG0768	penicillin binding
LEBU_RS01710	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
LEBU_RS01715	COG1534	Rna-binding protein
LEBU_RS01720	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
LEBU_RS01730	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
LEBU_RS01740	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
LEBU_RS01745	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
LEBU_RS01765	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LEBU_RS01770	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LEBU_RS01780	COG1126	abc transporter atp-binding protein
LEBU_RS01795	COG1126	abc transporter atp-binding protein
LEBU_RS01800	COG1301	dicarboxylic acid transport
LEBU_RS01810	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LEBU_RS01820	COG2183	response to ionizing radiation
LEBU_RS01825	COG1620	l-lactate permease
LEBU_RS01830	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
LEBU_RS01835	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
LEBU_RS01840	COG0752	glycyl-tRNA synthetase alpha subunit
LEBU_RS01855	COG0751	glycine-tRNA ligase activity
LEBU_RS01860	COG2885	chlorophyll binding
LEBU_RS01870	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LEBU_RS01870	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
LEBU_RS01875	COG1185	polyribonucleotide nucleotidyltransferase activity
LEBU_RS01875	COG0539	negative regulation of cytoplasmic translation
LEBU_RS01875	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
LEBU_RS01890	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LEBU_RS01895	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
LEBU_RS01900	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
LEBU_RS01910	COG0175	sulfate reduction
LEBU_RS01915	COG0529	Catalyzes the synthesis of activated sulfate
LEBU_RS01915	COG2895	sulfate adenylyltransferase (ATP) activity
LEBU_RS01920	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
LEBU_RS01925	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
LEBU_RS01930	COG4208	sulfate ABC transporter
LEBU_RS01935	COG0674	pyruvate-flavodoxin oxidoreductase activity
LEBU_RS01935	COG1013	pyruvate-flavodoxin oxidoreductase activity
LEBU_RS01935	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
LEBU_RS01935	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
LEBU_RS01940	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
LEBU_RS01940	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
LEBU_RS01945	COG1597	lipid kinase activity
LEBU_RS01955	COG1543	Belongs to the glycosyl hydrolase 57 family
LEBU_RS01965	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LEBU_RS01975	COG0254	rRNA binding
LEBU_RS02045	COG1396	sequence-specific DNA binding
LEBU_RS02055	COG3830	Belongs to the UPF0237 family
LEBU_RS02060	COG2848	UPF0210 protein
LEBU_RS02075	COG3189	MarR family transcriptional regulator
LEBU_RS02080	COG1051	belongs to the nudix hydrolase family
LEBU_RS02135	COG1686	Belongs to the peptidase S11 family
LEBU_RS02155	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
LEBU_RS02170	COG1160	GTP binding
LEBU_RS02190	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LEBU_RS02195	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LEBU_RS02200	COG1121	(ABC) transporter
LEBU_RS02205	COG0803	Belongs to the bacterial solute-binding protein 9 family
LEBU_RS02220	COG0616	signal peptide processing
LEBU_RS02225	COG1489	DNA binding
LEBU_RS02310	COG3716	PTS system mannose fructose sorbose family IID component
LEBU_RS02350	COG0561	phosphatase activity
LEBU_RS02365	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
LEBU_RS02365	COG0116	Belongs to the methyltransferase superfamily
LEBU_RS02370	COG1722	exodeoxyribonuclease VII activity
LEBU_RS02395	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
LEBU_RS02400	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
LEBU_RS02405	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
LEBU_RS02430	COG1477	protein flavinylation
LEBU_RS02440	COG0675	Transposase, IS605 OrfB family
LEBU_RS02450	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
LEBU_RS02455	COG0497	DNA recombination
LEBU_RS02460	COG4974	Belongs to the 'phage' integrase family
LEBU_RS02475	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LEBU_RS02485	COG0351	phosphomethylpyrimidine kinase
LEBU_RS02500	COG0396	ATPase activity
LEBU_RS02505	COG0719	Fe-S assembly protein
LEBU_RS02515	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
LEBU_RS02525	COG2176	DNA-directed DNA polymerase activity
LEBU_RS02535	COG2759	Belongs to the formate--tetrahydrofolate ligase family
LEBU_RS02555	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
LEBU_RS02570	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
LEBU_RS02595	COG0495	leucyl-tRNA aminoacylation
LEBU_RS02605	COG0583	DNA-binding transcription factor activity
LEBU_RS02610	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
LEBU_RS02615	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
LEBU_RS02620	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
LEBU_RS02630	COG2877	3-deoxy-8-phosphooctulonate synthase activity
LEBU_RS02635	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
LEBU_RS02635	COG0662	Cupin 2, conserved barrel domain protein
LEBU_RS02640	COG0517	IMP dehydrogenase activity
LEBU_RS02640	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
LEBU_RS02650	COG1216	Glycosyl transferase, family 2
LEBU_RS02650	COG1442	glycosyl transferase family 8
LEBU_RS02655	COG0482	sulfurtransferase activity
LEBU_RS02665	COG1272	protein, Hemolysin III
LEBU_RS02670	COG0811	peptide transport
LEBU_RS02685	COG0006	proline dipeptidase activity
LEBU_RS02710	COG0285	dihydrofolate synthase activity
LEBU_RS02715	COG0228	four-way junction DNA binding
LEBU_RS02725	COG0791	NLP P60 protein
LEBU_RS02745	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
LEBU_RS02750	COG0508	dehydrogenase complex catalyzes the overall conversion of
LEBU_RS02750	COG0022	dehydrogenase e1 component
LEBU_RS02755	COG0508	dehydrogenase complex catalyzes the overall conversion of
LEBU_RS02770	COG0095	Lipoate-protein ligase
LEBU_RS02785	COG0058	SHG alpha-glucan phosphorylase activity
LEBU_RS02800	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LEBU_RS02805	COG0601	transmembrane transport
LEBU_RS02810	COG4608	Belongs to the ABC transporter superfamily
LEBU_RS02845	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
LEBU_RS02860	COG0525	valine-tRNA ligase activity
LEBU_RS02880	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LEBU_RS02880	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LEBU_RS02880	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LEBU_RS02890	COG0675	Transposase, IS605 OrfB family
LEBU_RS02905	COG0778	Nitroreductase
LEBU_RS02930	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
LEBU_RS02935	COG1217	gtp-binding protein TYPA
LEBU_RS02965	COG0698	ribose 5-phosphate isomerase
LEBU_RS02975	COG1105	Belongs to the carbohydrate kinase PfkB family
LEBU_RS02985	COG1447	Phosphotransferase system cellobiose-specific component IIA
LEBU_RS02995	COG2723	6-phospho-beta-galactosidase activity
LEBU_RS03000	COG3682	Transcriptional regulator
LEBU_RS03005	COG2217	Heavy metal translocating P-type atpase
LEBU_RS03020	COG3634	alkyl hydroperoxide reductase activity
LEBU_RS03025	COG2239	Acts as a magnesium transporter
LEBU_RS03030	COG2239	Acts as a magnesium transporter
LEBU_RS03045	COG1064	alcohol dehydrogenase
LEBU_RS03055	COG1660	Displays ATPase and GTPase activities
LEBU_RS03060	COG0322	excinuclease ABC activity
LEBU_RS03070	COG3845	ABC transporter
LEBU_RS03075	COG4603	Belongs to the binding-protein-dependent transport system permease family
LEBU_RS03080	COG1079	Belongs to the binding-protein-dependent transport system permease family
LEBU_RS03085	COG2226	methyltransferase
LEBU_RS03115	COG0333	Belongs to the bacterial ribosomal protein bL32 family
LEBU_RS03125	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LEBU_RS03135	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
LEBU_RS03175	COG1450	Type ii and iii secretion system protein
LEBU_RS03180	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
LEBU_RS03180	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
LEBU_RS03185	COG1940	carbohydrate kinase activity
LEBU_RS03190	COG1459	type II secretion system
LEBU_RS03205	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
LEBU_RS03210	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
LEBU_RS03215	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
LEBU_RS03220	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LEBU_RS03230	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
LEBU_RS03235	COG1649	PFAM Uncharacterised BCR, COG1649
LEBU_RS03265	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
LEBU_RS03280	COG0355	proton-transporting ATP synthase activity, rotational mechanism
LEBU_RS03290	COG2261	transglycosylase associated protein
LEBU_RS03300	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
LEBU_RS03310	COG0786	glutamate:sodium symporter activity
LEBU_RS03315	COG2081	HI0933 family
LEBU_RS03320	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
LEBU_RS03350	COG3293	Transposase
LEBU_RS03360	COG0617	tRNA 3'-terminal CCA addition
LEBU_RS03365	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LEBU_RS03365	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LEBU_RS03370	COG1621	beta-fructofuranosidase activity
LEBU_RS03375	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
LEBU_RS03380	COG0110	maltose O-acetyltransferase activity
LEBU_RS03395	COG1011	Hydrolase
LEBU_RS03405	COG0251	oxidation-reduction process
LEBU_RS03415	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
LEBU_RS03425	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
LEBU_RS03435	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
LEBU_RS03440	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
LEBU_RS03455	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LEBU_RS03455	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LEBU_RS03470	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
LEBU_RS03485	COG1418	mRNA catabolic process
LEBU_RS03490	COG1692	metallophosphoesterase
LEBU_RS03500	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
LEBU_RS03505	COG0776	regulation of translation
LEBU_RS03510	COG0220	tRNA (guanine-N7-)-methyltransferase activity
LEBU_RS03510	COG1519	Transferase
LEBU_RS03515	COG0220	tRNA (guanine-N7-)-methyltransferase activity
LEBU_RS03515	COG1519	Transferase
LEBU_RS03520	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LEBU_RS03520	COG4797	methyltransferase
LEBU_RS03525	COG0668	transmembrane transport
LEBU_RS03530	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LEBU_RS03535	COG1490	D-aminoacyl-tRNA deacylase activity
LEBU_RS03540	COG0791	NLP P60 protein
LEBU_RS03545	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
LEBU_RS03550	COG0765	amino acid transport
LEBU_RS03585	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
LEBU_RS03590	COG2188	Transcriptional regulator
LEBU_RS03595	COG4221	oxidoreductase activity
LEBU_RS03605	COG2268	Band 7 protein
LEBU_RS03610	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
LEBU_RS03625	COG0442	prolyl-tRNA aminoacylation
LEBU_RS03645	COG0542	response to heat
LEBU_RS03670	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
LEBU_RS03695	COG2094	Belongs to the DNA glycosylase MPG family
LEBU_RS03705	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
LEBU_RS03710	COG0037	tRNA processing
LEBU_RS03715	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LEBU_RS03765	COG0666	response to abiotic stimulus
LEBU_RS03775	COG0693	protein deglycase activity
LEBU_RS03780	COG0275	rRNA processing
LEBU_RS03795	COG1269	ATP hydrolysis coupled proton transport
LEBU_RS03800	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LEBU_RS03805	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
LEBU_RS03810	COG1527	subunit (C
LEBU_RS03835	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
LEBU_RS03850	COG0534	Mate efflux family protein
LEBU_RS03860	COG0540	Belongs to the ATCase OTCase family
LEBU_RS03865	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
LEBU_RS03875	COG0284	orotidine-5'-phosphate decarboxylase activity
LEBU_RS03885	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
LEBU_RS03890	COG0561	phosphatase activity
LEBU_RS03940	COG0443	Heat shock 70 kDa protein
LEBU_RS03965	COG1744	ABC transporter substrate-binding protein PnrA-like
LEBU_RS03975	COG4260	virion core protein, lumpy skin disease virus
LEBU_RS03980	COG1842	Phage shock protein A
LEBU_RS03990	COG0653	protein targeting
LEBU_RS03995	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
LEBU_RS04000	COG1518	maintenance of DNA repeat elements
LEBU_RS04040	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LEBU_RS04055	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LEBU_RS04055	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LEBU_RS04070	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
LEBU_RS04080	COG0765	amino acid transport
LEBU_RS04100	COG2885	chlorophyll binding
LEBU_RS04120	COG1136	(ABC) transporter
LEBU_RS04135	COG0488	(ABC) transporter
LEBU_RS04145	COG0133	tryptophan synthase activity
LEBU_RS04150	COG0135	phosphoribosylanthranilate isomerase activity
LEBU_RS04155	COG0134	indole-3-glycerol-phosphate synthase activity
LEBU_RS04185	COG0512	Glutamine amidotransferase of anthranilate synthase
LEBU_RS04185	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
LEBU_RS04190	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
LEBU_RS04195	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LEBU_RS04200	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LEBU_RS04210	COG1447	Phosphotransferase system cellobiose-specific component IIA
LEBU_RS04215	COG0673	inositol 2-dehydrogenase activity
LEBU_RS04220	COG0110	maltose O-acetyltransferase activity
LEBU_RS04225	COG2217	Heavy metal translocating P-type atpase
LEBU_RS04245	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
LEBU_RS04255	COG0460	homoserine dehydrogenase
LEBU_RS04275	COG0459	protein refolding
LEBU_RS04285	COG0110	maltose O-acetyltransferase activity
LEBU_RS04290	COG3425	synthase
LEBU_RS04310	COG1381	Involved in DNA repair and RecF pathway recombination
LEBU_RS04320	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
LEBU_RS04340	COG1136	(ABC) transporter
LEBU_RS04345	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LEBU_RS04350	COG0295	cytidine deaminase activity
LEBU_RS04370	COG0488	(ABC) transporter
LEBU_RS04395	COG0205	6-phosphofructokinase activity
LEBU_RS04405	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
LEBU_RS04435	COG0776	regulation of translation
LEBU_RS04450	COG4120	Belongs to the binding-protein-dependent transport system permease family
LEBU_RS04520	COG3266	domain, Protein
LEBU_RS04520	COG0515	serine threonine protein kinase
LEBU_RS04610	COG3293	Transposase
LEBU_RS04710	COG0484	heat shock protein binding
LEBU_RS04745	COG0827	DNA restriction-modification system
LEBU_RS04760	COG0791	NLP P60 protein
LEBU_RS04835	COG3451	type IV secretory pathway VirB4
LEBU_RS04850	COG4962	Type ii secretion system protein e
LEBU_RS04910	COG3177	Filamentation induced by cAMP protein fic
LEBU_RS04920	COG4974	Belongs to the 'phage' integrase family
LEBU_RS04930	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LEBU_RS04935	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
LEBU_RS04940	COG0813	purine-nucleoside phosphorylase activity
LEBU_RS04945	COG2195	Cleaves the N-terminal amino acid of tripeptides
LEBU_RS04950	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
LEBU_RS04970	COG0542	response to heat
LEBU_RS04985	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
LEBU_RS04990	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
LEBU_RS04995	COG3541	Predicted nucleotidyltransferase
LEBU_RS05000	COG2213	PTS system mannitol-specific
LEBU_RS05000	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
LEBU_RS05005	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LEBU_RS05015	COG3037	sugar-specific permease SgaT UlaA
LEBU_RS05020	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
LEBU_RS05025	COG3958	Transketolase
LEBU_RS05040	COG0826	peptidase U32
LEBU_RS05050	COG4752	Belongs to the RNA methyltransferase TrmD family
LEBU_RS05060	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
LEBU_RS05065	COG0336	Belongs to the RNA methyltransferase TrmD family
LEBU_RS05095	COG0180	Tryptophanyl-tRNA synthetase
LEBU_RS05115	COG0443	Heat shock 70 kDa protein
LEBU_RS05130	COG0501	Belongs to the peptidase M48B family
LEBU_RS05185	COG5002	protein histidine kinase activity
LEBU_RS05190	COG0745	RESPONSE REGULATOR receiver
LEBU_RS05195	COG2188	Transcriptional regulator
LEBU_RS05200	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LEBU_RS05210	COG0083	homoserine kinase activity
LEBU_RS05240	COG1164	Oligoendopeptidase f
LEBU_RS05275	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
LEBU_RS05295	COG1121	(ABC) transporter
LEBU_RS05305	COG3339	Conserved Protein
LEBU_RS05310	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
LEBU_RS05405	COG1328	CTP reductase activity
LEBU_RS05405	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
LEBU_RS05440	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
LEBU_RS05445	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
LEBU_RS05470	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LEBU_RS05480	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LEBU_RS05485	COG1780	Probably involved in ribonucleotide reductase function
LEBU_RS05490	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LEBU_RS05495	COG0017	Asparaginyl-tRNA synthetase
LEBU_RS05505	COG0758	DNA mediated transformation
LEBU_RS05510	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LEBU_RS05515	COG4974	Belongs to the 'phage' integrase family
LEBU_RS05520	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
LEBU_RS05530	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
LEBU_RS05540	COG0012	GTP binding
LEBU_RS05550	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LEBU_RS05555	COG0446	pyridine nucleotide-disulphide oxidoreductase
LEBU_RS05590	COG4221	oxidoreductase activity
LEBU_RS05600	COG0261	This protein binds to 23S rRNA in the presence of protein L20
LEBU_RS05605	COG2868	ribosomal protein
LEBU_RS05610	COG0211	Belongs to the bacterial ribosomal protein bL27 family
LEBU_RS05620	COG2116	formate transmembrane transporter activity
LEBU_RS05640	COG0446	pyridine nucleotide-disulphide oxidoreductase
LEBU_RS05675	COG3023	N-Acetylmuramoyl-L-alanine amidase
LEBU_RS05680	COG0436	Aminotransferase
LEBU_RS05710	COG2189	Belongs to the N(4) N(6)-methyltransferase family
LEBU_RS05720	COG0698	ribose 5-phosphate isomerase
LEBU_RS05735	COG0482	sulfurtransferase activity
LEBU_RS05740	COG0679	Auxin Efflux Carrier
LEBU_RS05755	COG0765	amino acid transport
LEBU_RS05765	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
LEBU_RS05770	COG2011	ABC-type metal ion transport system permease component
LEBU_RS05775	COG1464	Belongs to the NlpA lipoprotein family
LEBU_RS05780	COG3590	peptidase
LEBU_RS05785	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
LEBU_RS05825	COG0820	rRNA (adenine-C2-)-methyltransferase activity
LEBU_RS05840	COG4115	mRNA cleavage
LEBU_RS05845	COG2252	PERMEase
LEBU_RS05850	COG1253	flavin adenine dinucleotide binding
LEBU_RS05865	COG0165	Argininosuccinate lyase
LEBU_RS05880	COG0218	Necessary for normal cell division and for the maintenance of normal septation
LEBU_RS05890	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LEBU_RS05915	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
LEBU_RS05920	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
LEBU_RS05930	COG1181	Belongs to the D-alanine--D-alanine ligase family
LEBU_RS05940	COG1132	(ABC) transporter
LEBU_RS05945	COG1132	(ABC) transporter
LEBU_RS05965	COG0481	GTPase activity
LEBU_RS05975	COG0556	nucleotide-excision repair
LEBU_RS05985	COG0582	viral genome integration into host DNA
LEBU_RS06000	COG0728	peptidoglycan biosynthetic process
LEBU_RS06005	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
LEBU_RS06010	COG0196	riboflavin kinase activity
LEBU_RS06020	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
LEBU_RS06020	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
LEBU_RS06025	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
LEBU_RS06035	COG0140	phosphoribosyl-ATP diphosphatase activity
LEBU_RS06035	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
LEBU_RS06060	COG0107	imidazoleglycerol-phosphate synthase activity
LEBU_RS06065	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
LEBU_RS06075	COG3293	Transposase
LEBU_RS06085	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
LEBU_RS06090	COG1353	crispr-associated protein
LEBU_RS06105	COG0131	Imidazoleglycerol-phosphate dehydratase
LEBU_RS06115	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
LEBU_RS06120	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LEBU_RS06130	COG1373	ATPase (AAA superfamily
LEBU_RS06135	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
LEBU_RS06140	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
LEBU_RS06145	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
LEBU_RS06155	COG1051	belongs to the nudix hydrolase family
LEBU_RS06165	COG0285	dihydrofolate synthase activity
LEBU_RS06185	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
LEBU_RS06185	COG0302	gtp cyclohydrolase
LEBU_RS06190	COG0302	gtp cyclohydrolase
LEBU_RS06190	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
LEBU_RS06205	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
LEBU_RS06210	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LEBU_RS06215	COG4783	chaperone-mediated protein folding
LEBU_RS06240	COG0745	RESPONSE REGULATOR receiver
LEBU_RS06245	COG0489	protein tyrosine kinase activity
LEBU_RS06255	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
LEBU_RS06270	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LEBU_RS06275	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
LEBU_RS06280	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
LEBU_RS06290	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LEBU_RS06305	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LEBU_RS06320	COG2378	regulation of single-species biofilm formation
LEBU_RS06335	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LEBU_RS06360	COG0778	Nitroreductase
LEBU_RS06365	COG0778	Nitroreductase
LEBU_RS06410	COG0537	adenosine 5'-monophosphoramidase activity
LEBU_RS06415	COG0698	ribose 5-phosphate isomerase
LEBU_RS06420	COG0824	Thioesterase
LEBU_RS06425	COG1837	Belongs to the UPF0109 family
LEBU_RS06430	COG0037	tRNA processing
LEBU_RS06450	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
LEBU_RS06460	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
LEBU_RS06465	COG0291	Belongs to the bacterial ribosomal protein bL35 family
LEBU_RS06470	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
LEBU_RS06480	COG3335	DDE superfamily endonuclease
LEBU_RS06485	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
LEBU_RS06490	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
LEBU_RS06495	COG0740	serine-type endopeptidase activity
LEBU_RS06500	COG0544	peptidyl-prolyl cis-trans isomerase activity
LEBU_RS06505	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
LEBU_RS06505	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
LEBU_RS06510	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
LEBU_RS06515	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
LEBU_RS06525	COG0195	Participates in both transcription termination and antitermination
LEBU_RS06530	COG0779	Required for maturation of 30S ribosomal subunits
LEBU_RS06535	COG2059	Chromate
LEBU_RS06540	COG2059	Chromate
LEBU_RS06555	COG0037	tRNA processing
LEBU_RS06560	COG0366	Alpha amylase catalytic
LEBU_RS06570	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
LEBU_RS06680	COG2205	protein histidine kinase activity
LEBU_RS06685	COG0745	RESPONSE REGULATOR receiver
LEBU_RS06705	COG1362	aminopeptidase activity
LEBU_RS06710	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LEBU_RS06715	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
LEBU_RS06725	COG0019	diaminopimelate decarboxylase activity
LEBU_RS06740	COG0675	Transposase, IS605 OrfB family
LEBU_RS06745	COG3552	Protein containing von Willebrand factor type A (VWA) domain
LEBU_RS06750	COG2425	protein containing a von Willebrand factor type A (vWA) domain
LEBU_RS06755	COG0714	Associated with various cellular activities
LEBU_RS06785	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
LEBU_RS06790	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LEBU_RS06795	COG2853	Lipoprotein
LEBU_RS06805	COG1196	nuclear chromosome segregation
LEBU_RS06810	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
LEBU_RS06830	COG1132	(ABC) transporter
LEBU_RS06835	COG1132	(ABC) transporter
LEBU_RS06840	COG1115	amino acid carrier protein
LEBU_RS06855	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
LEBU_RS06860	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
LEBU_RS06865	COG0210	DNA helicase
LEBU_RS06875	COG0366	Alpha amylase catalytic
LEBU_RS06875	COG3103	Sh3 type 3 domain protein
LEBU_RS06890	COG0792	nuclease activity
LEBU_RS06910	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
LEBU_RS06915	COG0564	pseudouridine synthase activity
LEBU_RS06950	COG0546	phosphoglycolate phosphatase activity
LEBU_RS06955	COG4224	UPF0291 protein
LEBU_RS06965	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LEBU_RS06985	COG3293	Transposase
LEBU_RS07055	COG1073	alpha beta
LEBU_RS07070	COG2272	Belongs to the type-B carboxylesterase lipase family
LEBU_RS07085	COG0583	DNA-binding transcription factor activity
LEBU_RS07090	COG0656	L-ascorbic acid biosynthetic process
LEBU_RS07105	COG0436	Aminotransferase
LEBU_RS07110	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LEBU_RS07120	COG0372	Belongs to the citrate synthase family
LEBU_RS07125	COG0473	3-isopropylmalate dehydrogenase activity
LEBU_RS07130	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
LEBU_RS07140	COG0745	RESPONSE REGULATOR receiver
LEBU_RS07145	COG5002	protein histidine kinase activity
LEBU_RS07155	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
LEBU_RS07160	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LEBU_RS07175	COG1185	polyribonucleotide nucleotidyltransferase activity
LEBU_RS07190	COG1174	glycine betaine transport
LEBU_RS07195	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
LEBU_RS07200	COG1125	glycine betaine transport
LEBU_RS07200	COG0517	IMP dehydrogenase activity
LEBU_RS07205	COG1846	Transcriptional regulator
LEBU_RS07210	COG1063	alcohol dehydrogenase
LEBU_RS07215	COG0646	methionine synthase
LEBU_RS07215	COG1410	methionine synthase
LEBU_RS07250	COG2885	chlorophyll binding
LEBU_RS07280	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
LEBU_RS07285	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
LEBU_RS07290	COG1525	nuclease
LEBU_RS07295	COG0626	cystathionine gamma-synthase activity
LEBU_RS07305	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
LEBU_RS07320	COG4720	Psort location CytoplasmicMembrane, score
LEBU_RS07330	COG1570	exodeoxyribonuclease VII activity
LEBU_RS07340	COG2226	methyltransferase
LEBU_RS07350	COG2207	Transcriptional regulator
LEBU_RS07350	COG1917	Cupin 2, conserved barrel domain protein
LEBU_RS07355	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LEBU_RS07355	COG1263	PTS System
LEBU_RS07360	COG1621	beta-fructofuranosidase activity
LEBU_RS07365	COG3842	ATPase activity
LEBU_RS07375	COG0395	ABC-type sugar transport system, permease component
LEBU_RS07380	COG1175	transmembrane transport
LEBU_RS07395	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
LEBU_RS07400	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
LEBU_RS07405	COG3872	metal-dependent enzyme
LEBU_RS07410	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
LEBU_RS07415	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
LEBU_RS07420	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
LEBU_RS07425	COG0571	ribonuclease III activity
LEBU_RS07430	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LEBU_RS07435	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LEBU_RS07450	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
LEBU_RS07455	COG0456	acetyltransferase
LEBU_RS07465	COG0335	large ribosomal subunit rRNA binding
LEBU_RS07500	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
LEBU_RS07505	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LEBU_RS07525	COG0366	Alpha amylase catalytic
LEBU_RS07530	COG1486	melibiose metabolic process
LEBU_RS07535	COG2188	Transcriptional regulator
LEBU_RS07540	COG1263	PTS System
LEBU_RS07540	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LEBU_RS07560	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
LEBU_RS07575	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
LEBU_RS07580	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
LEBU_RS07585	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LEBU_RS07590	COG1393	Belongs to the ArsC family
LEBU_RS07595	COG0616	signal peptide processing
LEBU_RS07605	COG0556	nucleotide-excision repair
LEBU_RS07610	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
LEBU_RS07615	COG2824	Alkylphosphonate utilization operon protein PhnA
LEBU_RS07620	COG0658	competence protein
LEBU_RS07620	COG2333	competence protein COMEC
LEBU_RS07660	COG0534	Mate efflux family protein
LEBU_RS07665	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
LEBU_RS07670	COG0583	DNA-binding transcription factor activity
LEBU_RS07700	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
LEBU_RS07715	COG1473	amidohydrolase
LEBU_RS07720	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LEBU_RS07725	COG1401	restriction endodeoxyribonuclease activity
LEBU_RS07735	COG2096	Adenosyltransferase
LEBU_RS07740	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
LEBU_RS07745	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LEBU_RS07765	COG3047	cAMP biosynthetic process
LEBU_RS07765	COG2885	chlorophyll binding
LEBU_RS07775	COG1902	pentaerythritol trinitrate reductase activity
LEBU_RS07805	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LEBU_RS07810	COG2731	YhcH YjgK YiaL family protein
LEBU_RS07815	COG1619	proteins homologs of microcin C7 resistance protein MccF
LEBU_RS07825	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
LEBU_RS07830	COG0151	Belongs to the GarS family
LEBU_RS07880	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
LEBU_RS07900	COG0513	Belongs to the DEAD box helicase family
LEBU_RS07925	COG5002	protein histidine kinase activity
LEBU_RS07970	COG0505	Belongs to the CarA family
LEBU_RS07975	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
LEBU_RS07985	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
LEBU_RS07990	COG0673	inositol 2-dehydrogenase activity
LEBU_RS07995	COG1215	transferase activity, transferring glycosyl groups
LEBU_RS08035	COG1116	anion transmembrane transporter activity
LEBU_RS08040	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LEBU_RS08045	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LEBU_RS08060	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
LEBU_RS08115	COG0667	Aldo Keto reductase
LEBU_RS08125	COG0583	DNA-binding transcription factor activity
LEBU_RS08150	COG0443	Heat shock 70 kDa protein
LEBU_RS08185	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
LEBU_RS08190	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LEBU_RS08200	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
LEBU_RS08205	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LEBU_RS08215	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
LEBU_RS08240	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
LEBU_RS08245	COG1187	pseudouridine synthase activity
LEBU_RS08250	COG1605	Chorismate mutase
LEBU_RS08250	COG0077	Prephenate dehydratase
LEBU_RS08255	COG0675	Transposase, IS605 OrfB family
LEBU_RS08265	COG1304	FMN binding
LEBU_RS08285	COG0233	cytoplasmic translational termination
LEBU_RS08290	COG0528	UMP kinase activity
LEBU_RS08295	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
LEBU_RS08315	COG0052	Belongs to the universal ribosomal protein uS2 family
LEBU_RS08325	COG0516	GMP reductase activity
LEBU_RS08325	COG0517	IMP dehydrogenase activity
LEBU_RS08330	COG1028	Short-chain dehydrogenase reductase Sdr
LEBU_RS08340	COG2195	Cleaves the N-terminal amino acid of tripeptides
LEBU_RS08345	COG2340	Cysteine-rich secretory protein family
LEBU_RS08365	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LEBU_RS08375	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
LEBU_RS08385	COG2137	regulation of response to DNA damage stimulus
LEBU_RS08390	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
LEBU_RS08400	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
LEBU_RS08405	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
LEBU_RS08420	COG2226	methyltransferase
LEBU_RS08425	COG0697	spore germination
LEBU_RS08435	COG1119	ATPase activity
LEBU_RS08440	COG0473	3-isopropylmalate dehydrogenase activity
LEBU_RS08445	COG3041	Addiction module toxin RelE StbE family
LEBU_RS08480	COG1119	ATPase activity
LEBU_RS08490	COG0473	3-isopropylmalate dehydrogenase activity
LEBU_RS08505	COG3041	Addiction module toxin RelE StbE family
LEBU_RS08540	COG0066	3-isopropylmalate dehydratase activity
LEBU_RS08545	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
LEBU_RS08550	COG3177	Filamentation induced by cAMP protein fic
LEBU_RS08560	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LEBU_RS08595	COG4221	oxidoreductase activity
LEBU_RS08625	COG1983	PspC domain protein
LEBU_RS08630	COG2249	NAD(P)H dehydrogenase (quinone) activity
LEBU_RS08645	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LEBU_RS08650	COG1794	racemase activity, acting on amino acids and derivatives
LEBU_RS08655	COG0500	methyltransferase
LEBU_RS08660	COG0440	acetolactate synthase activity
LEBU_RS08665	COG0028	Belongs to the TPP enzyme family
LEBU_RS08670	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
LEBU_RS08680	COG0657	acetylesterase activity
LEBU_RS08685	COG0129	dihydroxy-acid dehydratase activity
LEBU_RS08710	COG0343	queuine tRNA-ribosyltransferase activity
LEBU_RS08715	COG0084	hydrolase, TatD family'
LEBU_RS08735	COG1854	S-ribosylhomocysteine lyase activity
LEBU_RS08740	COG1181	Belongs to the D-alanine--D-alanine ligase family
LEBU_RS08745	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
LEBU_RS08760	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LEBU_RS08765	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LEBU_RS08775	COG2720	vancomycin resistance protein
LEBU_RS08800	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
LEBU_RS08805	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
LEBU_RS08815	COG3588	fructose-bisphosphate aldolase
LEBU_RS08820	COG0217	transcriptional regulatory protein
LEBU_RS08825	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
LEBU_RS08830	COG1454	alcohol dehydrogenase
LEBU_RS08850	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LEBU_RS08860	COG1227	inorganic diphosphatase activity
LEBU_RS08865	COG1074	ATP-dependent DNA helicase activity
LEBU_RS08895	COG0149	triose-phosphate isomerase activity
LEBU_RS08920	COG0268	Binds directly to 16S ribosomal RNA
LEBU_RS08955	COG2822	iron ion transport
LEBU_RS08960	COG2837	iron assimilation
LEBU_RS08965	COG0672	)-iron permease
LEBU_RS08970	COG0805	protein transport
LEBU_RS08990	COG1704	LemA family
LEBU_RS09010	COG0010	Belongs to the arginase family
LEBU_RS09015	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
LEBU_RS09025	COG1982	Orn Lys Arg decarboxylase major
LEBU_RS09075	COG1126	abc transporter atp-binding protein
LEBU_RS09080	COG0765	amino acid transport
LEBU_RS09085	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LEBU_RS09095	COG1063	alcohol dehydrogenase
LEBU_RS09100	COG0825	malonyl-CoA metabolic process
LEBU_RS09105	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
LEBU_RS09115	COG0772	Belongs to the SEDS family
LEBU_RS09120	COG0612	Peptidase, M16
LEBU_RS09140	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LEBU_RS09145	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LEBU_RS09150	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LEBU_RS09155	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
LEBU_RS09160	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LEBU_RS09170	COG1137	ATPase activity
LEBU_RS09205	COG3172	ATPase kinase involved in NAD metabolism
LEBU_RS09220	COG0301	tRNA thio-modification
LEBU_RS09225	COG1104	cysteine desulfurase activity
LEBU_RS09230	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
LEBU_RS09235	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
LEBU_RS09240	COG1480	7TM receptor with intracellular HD hydrolase
LEBU_RS09245	COG1199	ATP-dependent helicase activity
LEBU_RS09260	COG0124	histidyl-tRNA synthetase
LEBU_RS09270	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
LEBU_RS09275	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
LEBU_RS09280	COG2890	protein-(glutamine-N5) methyltransferase activity
LEBU_RS09290	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
LEBU_RS09310	COG0632	four-way junction helicase activity
LEBU_RS09315	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
LEBU_RS09320	COG1686	Belongs to the peptidase S11 family
LEBU_RS09330	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
LEBU_RS09340	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LEBU_RS09345	COG0358	DNA primase activity
LEBU_RS09355	COG0194	GDP metabolic process
LEBU_RS09360	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
LEBU_RS09370	COG0085	RNA polymerase activity
LEBU_RS09375	COG0222	ribosome binding
LEBU_RS09380	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
LEBU_RS09385	COG0081	regulation of translation
LEBU_RS09390	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
LEBU_RS09395	COG0250	Participates in transcription elongation, termination and antitermination
LEBU_RS09410	COG0267	Belongs to the bacterial ribosomal protein bL33 family
LEBU_RS09415	COG0058	SHG alpha-glucan phosphorylase activity
LEBU_RS09420	COG3958	Transketolase
LEBU_RS09425	COG3959	Transketolase, thiamine diphosphate binding domain
LEBU_RS09430	COG2211	Major facilitator Superfamily
LEBU_RS09440	COG1323	Belongs to the UPF0348 family
LEBU_RS09445	COG1263	PTS System
LEBU_RS09445	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LEBU_RS09450	COG1621	beta-fructofuranosidase activity
LEBU_RS09455	COG1609	Transcriptional regulator
LEBU_RS09475	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
LEBU_RS09480	COG1882	Formate acetyltransferase
LEBU_RS09490	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LEBU_RS09495	COG1968	undecaprenyl-diphosphatase activity
LEBU_RS09505	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LEBU_RS09520	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LEBU_RS09525	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
LEBU_RS09540	COG4667	esterase of the alpha-beta hydrolase superfamily
LEBU_RS09545	COG0783	Belongs to the Dps family
LEBU_RS09550	COG0606	chelatase, subunit chli
LEBU_RS09555	COG0218	Necessary for normal cell division and for the maintenance of normal septation
LEBU_RS09560	COG1316	TRANSCRIPTIONal
LEBU_RS09575	COG0439	Biotin carboxylase
LEBU_RS09590	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LEBU_RS09600	COG4658	electron transport chain
LEBU_RS09605	COG4656	Part of a membrane complex involved in electron transport
LEBU_RS09620	COG3118	belongs to the thioredoxin family
LEBU_RS09625	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LEBU_RS09640	COG2309	aminopeptidase activity
LEBU_RS09645	COG1263	PTS System
LEBU_RS09645	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LEBU_RS09645	COG2190	(PTS) system
LEBU_RS09650	COG1349	DNA-binding transcription factor activity
LEBU_RS09655	COG1882	Formate acetyltransferase
LEBU_RS09660	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
LEBU_RS09670	COG1349	DNA-binding transcription factor activity
LEBU_RS09675	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LEBU_RS09680	COG3118	belongs to the thioredoxin family
LEBU_RS09685	COG0492	ferredoxin-NADP+ reductase activity
LEBU_RS09715	COG0148	phosphopyruvate hydratase activity
LEBU_RS09725	COG0737	Belongs to the 5'-nucleotidase family
LEBU_RS09735	COG0737	Belongs to the 5'-nucleotidase family
LEBU_RS09745	COG3142	Participates in the control of copper homeostasis
LEBU_RS09750	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LEBU_RS09755	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
LEBU_RS09755	COG2755	lipolytic protein G-D-S-L family
LEBU_RS09775	COG1028	Short-chain dehydrogenase reductase Sdr
LEBU_RS09780	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
LEBU_RS09785	COG0726	polysaccharide deacetylase
LEBU_RS09795	COG0018	arginyl-trna synthetase
LEBU_RS09805	COG1648	precorrin-2 dehydrogenase activity
LEBU_RS09805	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LEBU_RS09810	COG0113	porphobilinogen synthase activity
LEBU_RS09815	COG0569	domain protein
LEBU_RS09820	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
LEBU_RS09825	COG1328	CTP reductase activity
LEBU_RS09825	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
LEBU_RS09835	COG2171	N-acyltransferase activity
LEBU_RS09845	COG1619	proteins homologs of microcin C7 resistance protein MccF
LEBU_RS09850	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
LEBU_RS09860	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
LEBU_RS09875	COG3293	Transposase
LEBU_RS09885	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
LEBU_RS09905	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
LEBU_RS09910	COG0393	Putative heavy-metal-binding
LEBU_RS09920	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
LEBU_RS09925	COG0557	exoribonuclease II activity
LEBU_RS09930	COG1713	HD superfamily hydrolase involved in NAD metabolism
LEBU_RS09935	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
LEBU_RS09945	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
LEBU_RS09950	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
LEBU_RS09955	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
LEBU_RS09960	COG0202	RNA polymerase activity
LEBU_RS09965	COG0203	ribosomal protein L17
LEBU_RS09975	COG3850	Histidine kinase
LEBU_RS09975	COG5002	protein histidine kinase activity
LEBU_RS10005	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
LEBU_RS10010	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
LEBU_RS10025	COG1215	transferase activity, transferring glycosyl groups
LEBU_RS10025	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
LEBU_RS10030	COG1442	glycosyl transferase family 8
LEBU_RS10030	COG1216	Glycosyl transferase, family 2
LEBU_RS10065	COG2801	Transposase and inactivated derivatives
LEBU_RS10085	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
LEBU_RS10095	COG2813	Specifically methylates the guanine in position
LEBU_RS10130	COG0588	phosphoglycerate mutase activity
LEBU_RS10135	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
LEBU_RS10160	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
LEBU_RS10170	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
LEBU_RS10175	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
LEBU_RS10180	COG0359	binds to the 23S rRNA
LEBU_RS10185	COG0305	Participates in initiation and elongation during chromosome replication
LEBU_RS10190	COG0826	peptidase U32
LEBU_RS10195	COG0745	RESPONSE REGULATOR receiver
LEBU_RS10200	COG5002	protein histidine kinase activity
LEBU_RS10205	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LEBU_RS10210	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
LEBU_RS10220	COG0561	phosphatase activity
LEBU_RS10225	COG0470	DNA polymerase III
LEBU_RS10230	COG1077	Cell shape determining protein MreB Mrl
LEBU_RS10265	COG0101	tRNA pseudouridine synthase activity
LEBU_RS10305	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LEBU_RS10305	COG0519	Catalyzes the synthesis of GMP from XMP
LEBU_RS10310	COG1454	alcohol dehydrogenase
LEBU_RS10310	COG1012	belongs to the aldehyde dehydrogenase family
LEBU_RS10315	COG1012	belongs to the aldehyde dehydrogenase family
LEBU_RS10325	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LEBU_RS10340	COG1994	Peptidase M50
LEBU_RS10360	COG1739	Uncharacterized protein family UPF0029
LEBU_RS10390	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
LEBU_RS10400	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LEBU_RS10405	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LEBU_RS10410	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
LEBU_RS10415	COG1799	cell septum assembly
LEBU_RS10420	COG0750	zinc metalloprotease
LEBU_RS10425	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
LEBU_RS10435	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
LEBU_RS10460	COG0859	PFAM glycosyl transferase family 9
LEBU_RS10465	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
LEBU_RS10470	COG0561	phosphatase activity
LEBU_RS10475	COG0561	phosphatase activity
LEBU_RS10480	COG2201	protein-glutamate methylesterase activity
LEBU_RS10485	COG0561	phosphatase activity
LEBU_RS10490	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
LEBU_RS10495	COG1193	negative regulation of DNA recombination
LEBU_RS10510	COG0215	cysteine-tRNA ligase activity
LEBU_RS10515	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
LEBU_RS10570	COG0563	adenylate kinase activity
LEBU_RS10580	COG3958	Transketolase
LEBU_RS10590	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LEBU_RS10590	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LEBU_RS10595	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
LEBU_RS10625	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
LEBU_RS10635	COG1482	cell wall glycoprotein biosynthetic process
LEBU_RS10645	COG0363	glucosamine-6-phosphate deaminase activity
LEBU_RS10650	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
LEBU_RS10655	COG0166	Belongs to the GPI family
LEBU_RS10660	COG1362	aminopeptidase activity
LEBU_RS10670	COG2003	Belongs to the UPF0758 family
LEBU_RS10675	COG1774	PSP1 C-terminal conserved region
LEBU_RS10710	COG1091	dTDP-4-dehydrorhamnose reductase activity
LEBU_RS10730	COG1210	Utp--glucose-1-phosphate uridylyltransferase
LEBU_RS10745	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LEBU_RS10755	COG0463	Glycosyl transferase, family 2
LEBU_RS10770	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
LEBU_RS10795	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
LEBU_RS10810	COG0193	aminoacyl-tRNA hydrolase activity
LEBU_RS10820	COG5002	protein histidine kinase activity
LEBU_RS10820	COG3850	Histidine kinase
LEBU_RS10825	COG0745	RESPONSE REGULATOR receiver
LEBU_RS10845	COG0072	phenylalanine-tRNA ligase activity
LEBU_RS10845	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LEBU_RS10855	COG3878	Protein conserved in bacteria
LEBU_RS10860	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
LEBU_RS10875	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
LEBU_RS10895	COG0675	Transposase, IS605 OrfB family
LEBU_RS10920	COG1162	GTPase activity
LEBU_RS10925	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
LEBU_RS10940	COG1293	RNA-binding protein homologous to eukaryotic snRNP
LEBU_RS10945	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LEBU_RS10955	COG0191	fructose-bisphosphate aldolase activity
LEBU_RS10965	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
LEBU_RS11000	COG0736	holo-[acyl-carrier-protein] synthase activity
LEBU_RS11070	COG0683	leucine binding
LEBU_RS11075	COG0559	Belongs to the binding-protein-dependent transport system permease family
LEBU_RS11110	COG1420	regulation of RNA biosynthetic process
LEBU_RS11120	COG0443	Heat shock 70 kDa protein
LEBU_RS11140	COG0484	heat shock protein binding
LEBU_RS11160	COG1059	Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine 7-oxoG) from DNA. Also nicks DNA at apurinic apyrimidinic sites (AP sites)
LEBU_RS11175	COG0167	dihydroorotate dehydrogenase activity
LEBU_RS11185	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LEBU_RS11195	COG1263	PTS System
LEBU_RS11195	COG2190	(PTS) system
LEBU_RS11195	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LEBU_RS11205	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
LEBU_RS11210	COG0768	penicillin binding
LEBU_RS11215	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LEBU_RS11220	COG0154	amidase activity
LEBU_RS11225	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LEBU_RS11230	COG0863	Belongs to the N(4) N(6)-methyltransferase family
LEBU_RS11260	COG1187	pseudouridine synthase activity
LEBU_RS11265	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
LEBU_RS11270	COG1077	Cell shape determining protein MreB Mrl
LEBU_RS11280	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
LEBU_RS11285	COG4589	Belongs to the CDS family
LEBU_RS11290	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
LEBU_RS11300	COG0859	PFAM glycosyl transferase family 9
LEBU_RS11305	COG3307	-O-antigen
LEBU_RS11315	COG0438	transferase activity, transferring glycosyl groups
LEBU_RS11315	COG0297	glycogen (starch) synthase activity
LEBU_RS11340	COG0726	polysaccharide deacetylase
LEBU_RS11345	COG1132	(ABC) transporter
LEBU_RS11355	COG1805	sodium ion transport
LEBU_RS11360	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
LEBU_RS11380	COG2088	sporulation resulting in formation of a cellular spore
LEBU_RS11385	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
LEBU_RS11395	COG2304	oxidoreductase activity
LEBU_RS11410	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
LEBU_RS11415	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
LEBU_RS11420	COG4166	transmembrane transport
LEBU_RS11425	COG4166	transmembrane transport
LEBU_RS11430	COG4166	transmembrane transport
LEBU_RS11435	COG4166	transmembrane transport
LEBU_RS11440	COG4608	Belongs to the ABC transporter superfamily
LEBU_RS11445	COG0444	Belongs to the ABC transporter superfamily
LEBU_RS11450	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LEBU_RS11455	COG0601	transmembrane transport
LEBU_RS11470	COG3716	PTS system mannose fructose sorbose family IID component
LEBU_RS11475	COG3715	PTS system
LEBU_RS11480	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LEBU_RS11480	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
LEBU_RS11485	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LEBU_RS11485	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
LEBU_RS11500	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
LEBU_RS11505	COG0187	DNA topoisomerase II activity
LEBU_RS11510	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
LEBU_RS11515	COG1847	R3H domain protein
LEBU_RS11520	COG0706	membrane insertase activity
LEBU_RS11525	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
LEBU_RS11530	COG0594	ribonuclease P activity