locus-tag	class	description
AMK43_RS00010	COG0594	ribonuclease P activity
AMK43_RS00015	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AMK43_RS00020	COG0706	membrane insertase activity
AMK43_RS00030	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AMK43_RS00035	COG0187	DNA topoisomerase II activity
AMK43_RS00045	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AMK43_RS00080	COG2094	Belongs to the DNA glycosylase MPG family
AMK43_RS00095	COG2226	methyltransferase
AMK43_RS00100	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
AMK43_RS00120	COG4770	biotin carboxylase activity
AMK43_RS00125	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
AMK43_RS00140	COG2801	Transposase and inactivated derivatives
AMK43_RS00160	COG1131	(ABC) transporter
AMK43_RS00170	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AMK43_RS00175	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AMK43_RS00175	COG0072	phenylalanine-tRNA ligase activity
AMK43_RS00185	COG1192	Involved in chromosome partitioning
AMK43_RS00195	COG0564	pseudouridine synthase activity
AMK43_RS00200	COG0574	Belongs to the PEP-utilizing enzyme family
AMK43_RS00200	COG3848	Pyruvate phosphate dikinase
AMK43_RS00220	COG0318	PFAM AMP-dependent synthetase and ligase
AMK43_RS00270	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AMK43_RS00275	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AMK43_RS00280	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AMK43_RS00285	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AMK43_RS00290	COG0772	Belongs to the SEDS family
AMK43_RS00295	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AMK43_RS00300	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AMK43_RS00305	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AMK43_RS00315	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AMK43_RS00320	COG0360	Binds together with S18 to 16S ribosomal RNA
AMK43_RS00330	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AMK43_RS00350	COG4894	glucomannan catabolic process
AMK43_RS00355	COG0488	(ABC) transporter
AMK43_RS00365	COG1966	Carbon starvation protein
AMK43_RS00375	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AMK43_RS00380	COG0049	tRNA binding
AMK43_RS00385	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AMK43_RS00390	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AMK43_RS00395	COG0051	transcription antitermination factor activity, RNA binding
AMK43_RS00400	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AMK43_RS00405	COG0088	Forms part of the polypeptide exit tunnel
AMK43_RS00410	COG0089	rRNA binding
AMK43_RS00415	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AMK43_RS00420	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AMK43_RS00425	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AMK43_RS00430	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AMK43_RS00435	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AMK43_RS00440	COG0255	Belongs to the universal ribosomal protein uL29 family
AMK43_RS00445	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AMK43_RS00450	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AMK43_RS00460	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AMK43_RS00465	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AMK43_RS00470	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AMK43_RS00475	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AMK43_RS00480	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AMK43_RS00485	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AMK43_RS00490	COG1841	ribosomal large subunit assembly
AMK43_RS00495	COG0200	Binds to the 23S rRNA
AMK43_RS00500	COG0201	protein transport
AMK43_RS00515	COG0519	Catalyzes the synthesis of GMP from XMP
AMK43_RS00520	COG2378	regulation of single-species biofilm formation
AMK43_RS00530	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
AMK43_RS00535	COG3639	organic phosphonate transmembrane transporter activity
AMK43_RS00550	COG1077	Cell shape determining protein MreB Mrl
AMK43_RS00555	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AMK43_RS00560	COG1187	pseudouridine synthase activity
AMK43_RS00585	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AMK43_RS00595	COG0154	amidase activity
AMK43_RS00610	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AMK43_RS00615	COG0768	penicillin binding
AMK43_RS00620	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AMK43_RS00625	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
AMK43_RS00630	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AMK43_RS00640	COG0534	Mate efflux family protein
AMK43_RS00650	COG0583	DNA-binding transcription factor activity
AMK43_RS00655	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AMK43_RS00660	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AMK43_RS00665	COG0038	chloride channel
AMK43_RS00675	COG1116	anion transmembrane transporter activity
AMK43_RS00705	COG1285	pathogenesis
AMK43_RS00730	COG1492	cobalamin metabolic process
AMK43_RS00745	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AMK43_RS00750	COG0588	phosphoglycerate mutase activity
AMK43_RS00755	COG0181	hydroxymethylbilane synthase activity
AMK43_RS00770	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
AMK43_RS00775	COG0588	phosphoglycerate mutase activity
AMK43_RS00780	COG2099	Precorrin-6x reductase
AMK43_RS00785	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
AMK43_RS00790	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
AMK43_RS00795	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AMK43_RS00795	COG1648	precorrin-2 dehydrogenase activity
AMK43_RS00800	COG0113	porphobilinogen synthase activity
AMK43_RS00810	COG0310	cobalt ion transport
AMK43_RS00830	COG1797	cobyrinic acid a,c-diamide synthase activity
AMK43_RS00840	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
AMK43_RS00855	COG1373	ATPase (AAA superfamily
AMK43_RS00980	COG1840	ABC-type Fe3 transport system, periplasmic component
AMK43_RS00990	COG3842	ATPase activity
AMK43_RS00995	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
AMK43_RS01020	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AMK43_RS01035	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AMK43_RS01035	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AMK43_RS01045	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AMK43_RS01050	COG1737	Transcriptional regulator
AMK43_RS01060	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AMK43_RS01065	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AMK43_RS01065	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AMK43_RS01065	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AMK43_RS01070	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AMK43_RS01075	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AMK43_RS01080	COG1349	DNA-binding transcription factor activity
AMK43_RS01085	COG1882	Formate acetyltransferase
AMK43_RS01100	COG2885	chlorophyll binding
AMK43_RS01105	COG0626	cystathionine gamma-synthase activity
AMK43_RS01110	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AMK43_RS01125	COG0719	Fe-S assembly protein
AMK43_RS01130	COG0396	ATPase activity
AMK43_RS01135	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AMK43_RS01150	COG0674	pyruvate-flavodoxin oxidoreductase activity
AMK43_RS01150	COG1013	pyruvate-flavodoxin oxidoreductase activity
AMK43_RS01150	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AMK43_RS01150	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AMK43_RS01155	COG1051	belongs to the nudix hydrolase family
AMK43_RS01195	COG2183	response to ionizing radiation
AMK43_RS01200	COG1620	l-lactate permease
AMK43_RS01205	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AMK43_RS01210	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AMK43_RS01215	COG0752	glycyl-tRNA synthetase alpha subunit
AMK43_RS01220	COG0751	glycine-tRNA ligase activity
AMK43_RS01230	COG0563	adenylate kinase activity
AMK43_RS01245	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AMK43_RS01260	COG0561	phosphatase activity
AMK43_RS01265	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AMK43_RS01280	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AMK43_RS01285	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AMK43_RS01290	COG0202	RNA polymerase activity
AMK43_RS01295	COG0203	ribosomal protein L17
AMK43_RS01300	COG1114	Component of the transport system for branched-chain amino acids
AMK43_RS01310	COG2801	Transposase and inactivated derivatives
AMK43_RS01315	COG3700	Belongs to the class B bacterial acid phosphatase family
AMK43_RS01340	COG4399	Belongs to the UPF0754 family
AMK43_RS01340	COG4399	Belongs to the UPF0754 family
AMK43_RS01345	COG2255	four-way junction helicase activity
AMK43_RS01355	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AMK43_RS01360	COG0799	negative regulation of ribosome biogenesis
AMK43_RS01365	COG0768	penicillin binding
AMK43_RS01370	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AMK43_RS01375	COG1534	Rna-binding protein
AMK43_RS01385	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
AMK43_RS01395	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AMK43_RS01400	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
AMK43_RS01405	COG0438	transferase activity, transferring glycosyl groups
AMK43_RS01430	COG0438	transferase activity, transferring glycosyl groups
AMK43_RS01445	COG2342	PFAM TM1410 hypothetical-related protein
AMK43_RS01475	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AMK43_RS01480	COG0101	tRNA pseudouridine synthase activity
AMK43_RS01495	COG1528	Iron-storage protein
AMK43_RS01500	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AMK43_RS01505	COG0148	phosphopyruvate hydratase activity
AMK43_RS01525	COG2003	Belongs to the UPF0758 family
AMK43_RS01530	COG1774	PSP1 C-terminal conserved region
AMK43_RS01535	COG1774	PSP1 C-terminal conserved region
AMK43_RS01550	COG0561	phosphatase activity
AMK43_RS01555	COG2201	protein-glutamate methylesterase activity
AMK43_RS01560	COG0561	phosphatase activity
AMK43_RS01565	COG0616	signal peptide processing
AMK43_RS01600	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AMK43_RS01605	COG0714	Associated with various cellular activities
AMK43_RS01615	COG2425	protein containing a von Willebrand factor type A (vWA) domain
AMK43_RS01625	COG1309	transcriptional regulator
AMK43_RS01630	COG2814	Major facilitator Superfamily
AMK43_RS01645	COG0133	tryptophan synthase activity
AMK43_RS01650	COG0134	indole-3-glycerol-phosphate synthase activity
AMK43_RS01650	COG0135	phosphoribosylanthranilate isomerase activity
AMK43_RS01655	COG0134	indole-3-glycerol-phosphate synthase activity
AMK43_RS01660	COG0512	Glutamine amidotransferase of anthranilate synthase
AMK43_RS01660	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AMK43_RS01670	COG1263	PTS System
AMK43_RS01670	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AMK43_RS01675	COG1737	Transcriptional regulator
AMK43_RS01680	COG1486	melibiose metabolic process
AMK43_RS01685	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AMK43_RS01690	COG1447	Phosphotransferase system cellobiose-specific component IIA
AMK43_RS01700	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AMK43_RS01705	COG2723	6-phospho-beta-galactosidase activity
AMK43_RS01715	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AMK43_RS01720	COG0346	lactoylglutathione lyase activity
AMK43_RS01725	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AMK43_RS01730	COG1120	ATPase activity
AMK43_RS01735	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
AMK43_RS01760	COG2226	methyltransferase
AMK43_RS01780	COG0542	response to heat
AMK43_RS01785	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AMK43_RS01790	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AMK43_RS01795	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AMK43_RS01800	COG1799	cell septum assembly
AMK43_RS01805	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
AMK43_RS01815	COG0750	zinc metalloprotease
AMK43_RS01850	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AMK43_RS01860	COG1940	carbohydrate kinase activity
AMK43_RS01865	COG1879	ABC-type sugar transport system periplasmic component
AMK43_RS01885	COG1132	(ABC) transporter
AMK43_RS01890	COG1132	(ABC) transporter
AMK43_RS01895	COG1917	Cupin 2, conserved barrel domain protein
AMK43_RS01895	COG4977	sequence-specific DNA binding
AMK43_RS01900	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AMK43_RS01905	COG4589	Belongs to the CDS family
AMK43_RS01910	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AMK43_RS01930	COG1304	FMN binding
AMK43_RS01940	COG0488	(ABC) transporter
AMK43_RS01945	COG1132	(ABC) transporter
AMK43_RS01950	COG1132	(ABC) transporter
AMK43_RS01965	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AMK43_RS01970	COG1121	(ABC) transporter
AMK43_RS01980	COG0588	phosphoglycerate mutase activity
AMK43_RS01990	COG0569	domain protein
AMK43_RS01995	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AMK43_RS02000	COG2226	methyltransferase
AMK43_RS02005	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
AMK43_RS02015	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
AMK43_RS02020	COG0517	IMP dehydrogenase activity
AMK43_RS02025	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AMK43_RS02025	COG0574	Belongs to the PEP-utilizing enzyme family
AMK43_RS02035	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AMK43_RS02040	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AMK43_RS02080	COG1193	negative regulation of DNA recombination
AMK43_RS02085	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AMK43_RS02095	COG0215	cysteine-tRNA ligase activity
AMK43_RS02100	COG1077	Cell shape determining protein MreB Mrl
AMK43_RS02105	COG0470	DNA polymerase III
AMK43_RS02140	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
AMK43_RS02145	COG0037	tRNA processing
AMK43_RS02155	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
AMK43_RS02155	COG1918	ferrous iron import across plasma membrane
AMK43_RS02160	COG1918	ferrous iron import across plasma membrane
AMK43_RS02160	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
AMK43_RS02170	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AMK43_RS02175	COG0009	L-threonylcarbamoyladenylate synthase
AMK43_RS02210	COG0583	DNA-binding transcription factor activity
AMK43_RS02215	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
AMK43_RS02220	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AMK43_RS02230	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AMK43_RS02240	COG1116	anion transmembrane transporter activity
AMK43_RS02245	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AMK43_RS02255	COG3340	Belongs to the peptidase S51 family
AMK43_RS02270	COG2304	oxidoreductase activity
AMK43_RS02280	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
AMK43_RS02285	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
AMK43_RS02310	COG0252	asparaginase activity
AMK43_RS02315	COG0335	large ribosomal subunit rRNA binding
AMK43_RS02325	COG0456	acetyltransferase
AMK43_RS02330	COG0525	valine-tRNA ligase activity
AMK43_RS02345	COG0149	triose-phosphate isomerase activity
AMK43_RS02360	COG0210	DNA helicase
AMK43_RS02365	COG1272	protein, Hemolysin III
AMK43_RS02370	COG1846	Transcriptional regulator
AMK43_RS02375	COG0811	peptide transport
AMK43_RS02380	COG0848	biopolymer transport protein
AMK43_RS02390	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AMK43_RS02395	COG1120	ATPase activity
AMK43_RS02400	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AMK43_RS02415	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AMK43_RS02430	COG3210	domain, Protein
AMK43_RS02490	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AMK43_RS02495	COG0124	histidyl-tRNA synthetase
AMK43_RS02500	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AMK43_RS02510	COG1263	PTS System
AMK43_RS02510	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AMK43_RS02625	COG4796	Type ii and iii secretion system protein
AMK43_RS02630	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
AMK43_RS02630	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AMK43_RS02635	COG1940	carbohydrate kinase activity
AMK43_RS02645	COG1459	type II secretion system
AMK43_RS02660	COG1649	PFAM Uncharacterised BCR, COG1649
AMK43_RS02665	COG0786	glutamate:sodium symporter activity
AMK43_RS02670	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AMK43_RS02685	COG0285	dihydrofolate synthase activity
AMK43_RS02690	COG1288	antiporter activity
AMK43_RS02695	COG0228	four-way junction DNA binding
AMK43_RS02700	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AMK43_RS02705	COG0022	dehydrogenase e1 component
AMK43_RS02710	COG0508	dehydrogenase complex catalyzes the overall conversion of
AMK43_RS02715	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AMK43_RS02720	COG0095	Lipoate-protein ligase
AMK43_RS02725	COG0531	amino acid
AMK43_RS02730	COG3189	MarR family transcriptional regulator
AMK43_RS02740	COG1175	transmembrane transport
AMK43_RS02745	COG0395	ABC-type sugar transport system, permease component
AMK43_RS02755	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AMK43_RS02755	COG2190	(PTS) system
AMK43_RS02755	COG1263	PTS System
AMK43_RS02800	COG2188	Transcriptional regulator
AMK43_RS02820	COG1735	metal-dependent hydrolase with the TIM-barrel fold
AMK43_RS02825	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AMK43_RS02830	COG0626	cystathionine gamma-synthase activity
AMK43_RS02835	COG3457	Alanine racemase
AMK43_RS02840	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
AMK43_RS02850	COG0556	nucleotide-excision repair
AMK43_RS02855	COG1393	Belongs to the ArsC family
AMK43_RS02890	COG4720	Psort location CytoplasmicMembrane, score
AMK43_RS02910	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AMK43_RS02915	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AMK43_RS02915	COG1263	PTS System
AMK43_RS02935	COG1175	transmembrane transport
AMK43_RS02945	COG5012	cobalamin binding
AMK43_RS02985	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AMK43_RS02990	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AMK43_RS02995	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AMK43_RS02995	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AMK43_RS02995	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AMK43_RS03005	COG2249	NAD(P)H dehydrogenase (quinone) activity
AMK43_RS03025	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
AMK43_RS03030	COG1362	aminopeptidase activity
AMK43_RS03035	COG0656	L-ascorbic acid biosynthetic process
AMK43_RS03040	COG2059	Chromate
AMK43_RS03045	COG2059	Chromate
AMK43_RS03050	COG3842	ATPase activity
AMK43_RS03055	COG1176	ABC-type spermidine putrescine transport system, permease component I
AMK43_RS03060	COG1177	transmembrane transport
AMK43_RS03065	COG0513	Belongs to the DEAD box helicase family
AMK43_RS03070	COG1011	Hydrolase
AMK43_RS03080	COG1597	lipid kinase activity
AMK43_RS03085	COG1543	Belongs to the glycosyl hydrolase 57 family
AMK43_RS03180	COG3177	Filamentation induced by cAMP protein fic
AMK43_RS03190	COG0301	tRNA thio-modification
AMK43_RS03210	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AMK43_RS03225	COG0250	Participates in transcription elongation, termination and antitermination
AMK43_RS03230	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AMK43_RS03235	COG0081	regulation of translation
AMK43_RS03240	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AMK43_RS03245	COG0222	ribosome binding
AMK43_RS03250	COG0085	RNA polymerase activity
AMK43_RS03260	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AMK43_RS03265	COG0194	GDP metabolic process
AMK43_RS03275	COG0358	DNA primase activity
AMK43_RS03290	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AMK43_RS03295	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AMK43_RS03300	COG0497	DNA recombination
AMK43_RS03305	COG4974	Belongs to the 'phage' integrase family
AMK43_RS03320	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AMK43_RS03325	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
AMK43_RS03350	COG4752	Belongs to the RNA methyltransferase TrmD family
AMK43_RS03360	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AMK43_RS03395	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AMK43_RS03400	COG0495	leucyl-tRNA aminoacylation
AMK43_RS03420	COG1174	glycine betaine transport
AMK43_RS03425	COG0517	IMP dehydrogenase activity
AMK43_RS03425	COG1125	glycine betaine transport
AMK43_RS03435	COG0482	sulfurtransferase activity
AMK43_RS03440	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AMK43_RS03445	COG2081	HI0933 family
AMK43_RS03450	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
AMK43_RS03455	COG0006	proline dipeptidase activity
AMK43_RS03465	COG1288	antiporter activity
AMK43_RS03480	COG2239	Acts as a magnesium transporter
AMK43_RS03485	COG2239	Acts as a magnesium transporter
AMK43_RS03505	COG0733	neurotransmitter:sodium symporter activity
AMK43_RS03525	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AMK43_RS03555	COG2188	Transcriptional regulator
AMK43_RS03565	COG0058	SHG alpha-glucan phosphorylase activity
AMK43_RS03575	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AMK43_RS03575	COG1263	PTS System
AMK43_RS03580	COG2188	Transcriptional regulator
AMK43_RS03585	COG1486	melibiose metabolic process
AMK43_RS03590	COG0366	Alpha amylase catalytic
AMK43_RS03605	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AMK43_RS03610	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AMK43_RS03620	COG1363	Peptidase, m42
AMK43_RS03625	COG1363	Peptidase, m42
AMK43_RS03630	COG1446	asparaginase
AMK43_RS03635	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AMK43_RS03655	COG0745	RESPONSE REGULATOR receiver
AMK43_RS03665	COG2378	regulation of single-species biofilm formation
AMK43_RS03700	COG5002	protein histidine kinase activity
AMK43_RS03705	COG0745	RESPONSE REGULATOR receiver
AMK43_RS03765	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AMK43_RS03780	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AMK43_RS03820	COG2877	3-deoxy-8-phosphooctulonate synthase activity
AMK43_RS03825	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AMK43_RS03830	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AMK43_RS03860	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AMK43_RS03865	COG0359	binds to the 23S rRNA
AMK43_RS03870	COG0305	Participates in initiation and elongation during chromosome replication
AMK43_RS03875	COG0826	peptidase U32
AMK43_RS03880	COG0745	RESPONSE REGULATOR receiver
AMK43_RS03885	COG5002	protein histidine kinase activity
AMK43_RS03890	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AMK43_RS03930	COG0826	peptidase U32
AMK43_RS03955	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
AMK43_RS03960	COG4656	Part of a membrane complex involved in electron transport
AMK43_RS03965	COG4658	electron transport chain
AMK43_RS03970	COG4659	FMN binding
AMK43_RS03980	COG4657	Part of a membrane complex involved in electron transport
AMK43_RS03990	COG2878	Part of a membrane complex involved in electron transport
AMK43_RS04010	COG0268	Binds directly to 16S ribosomal RNA
AMK43_RS04050	COG0803	Belongs to the bacterial solute-binding protein 9 family
AMK43_RS04080	COG1199	ATP-dependent helicase activity
AMK43_RS04085	COG1480	7TM receptor with intracellular HD hydrolase
AMK43_RS04090	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AMK43_RS04095	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AMK43_RS04105	COG1227	inorganic diphosphatase activity
AMK43_RS04110	COG4555	ABC transporter
AMK43_RS04160	COG3425	synthase
AMK43_RS04195	COG3590	peptidase
AMK43_RS04230	COG3250	beta-galactosidase activity
AMK43_RS04235	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AMK43_RS04255	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AMK43_RS04255	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AMK43_RS04255	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AMK43_RS04260	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AMK43_RS04275	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AMK43_RS04285	COG1136	(ABC) transporter
AMK43_RS04290	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AMK43_RS04295	COG2195	Cleaves the N-terminal amino acid of tripeptides
AMK43_RS04310	COG0251	oxidation-reduction process
AMK43_RS04315	COG1473	amidohydrolase
AMK43_RS04320	COG1464	Belongs to the NlpA lipoprotein family
AMK43_RS04330	COG2011	ABC-type metal ion transport system permease component
AMK43_RS04345	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AMK43_RS04350	COG2171	N-acyltransferase activity
AMK43_RS04360	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AMK43_RS04365	COG2137	regulation of response to DNA damage stimulus
AMK43_RS04375	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AMK43_RS04380	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AMK43_RS04390	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AMK43_RS04415	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AMK43_RS04435	COG0776	regulation of translation
AMK43_RS04450	COG4120	Belongs to the binding-protein-dependent transport system permease family
AMK43_RS04505	COG0515	serine threonine protein kinase
AMK43_RS04505	COG2815	serine threonine protein kinase
AMK43_RS04520	COG0739	heme binding
AMK43_RS04530	COG4224	UPF0291 protein
AMK43_RS04535	COG0546	phosphoglycolate phosphatase activity
AMK43_RS04540	COG0101	tRNA pseudouridine synthase activity
AMK43_RS04550	COG0564	pseudouridine synthase activity
AMK43_RS04555	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AMK43_RS04560	COG0792	nuclease activity
AMK43_RS04575	COG0366	Alpha amylase catalytic
AMK43_RS04575	COG3103	Sh3 type 3 domain protein
AMK43_RS04580	COG2096	Adenosyltransferase
AMK43_RS04610	COG3179	chitinase
AMK43_RS04625	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
AMK43_RS04630	COG4221	oxidoreductase activity
AMK43_RS04635	COG1473	amidohydrolase
AMK43_RS04640	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AMK43_RS04645	COG0765	amino acid transport
AMK43_RS04655	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AMK43_RS04660	COG2011	ABC-type metal ion transport system permease component
AMK43_RS04665	COG1464	Belongs to the NlpA lipoprotein family
AMK43_RS04670	COG1464	Belongs to the NlpA lipoprotein family
AMK43_RS04680	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AMK43_RS04685	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AMK43_RS04690	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AMK43_RS04695	COG1058	Belongs to the CinA family
AMK43_RS04695	COG1546	Belongs to the CinA family
AMK43_RS04720	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AMK43_RS04725	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AMK43_RS04735	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AMK43_RS04735	COG0493	'glutamate synthase
AMK43_RS04740	COG0402	S-adenosylhomocysteine deaminase activity
AMK43_RS04745	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AMK43_RS04755	COG0521	Mo-molybdopterin cofactor biosynthetic process
AMK43_RS04760	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AMK43_RS04780	COG4149	molybdate abc transporter
AMK43_RS04785	COG0315	cyclic pyranopterin monophosphate synthase activity
AMK43_RS04790	COG0725	ABC transporter, periplasmic molybdate-binding protein
AMK43_RS04795	COG3608	succinylglutamate desuccinylase aspartoacylase
AMK43_RS04795	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
AMK43_RS04800	COG3608	succinylglutamate desuccinylase aspartoacylase
AMK43_RS04800	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
AMK43_RS04815	COG1733	regulation of RNA biosynthetic process
AMK43_RS04820	COG0475	glutathione-regulated potassium exporter activity
AMK43_RS04820	COG0589	response to stress
AMK43_RS04835	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
AMK43_RS04835	COG0517	IMP dehydrogenase activity
AMK43_RS04895	COG0779	Required for maturation of 30S ribosomal subunits
AMK43_RS04900	COG0195	Participates in both transcription termination and antitermination
AMK43_RS04915	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AMK43_RS04920	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AMK43_RS04920	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
AMK43_RS04925	COG0544	peptidyl-prolyl cis-trans isomerase activity
AMK43_RS04930	COG0740	serine-type endopeptidase activity
AMK43_RS04935	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AMK43_RS04940	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AMK43_RS04945	COG1760	l-serine dehydratase
AMK43_RS04970	COG0791	NLP P60 protein
AMK43_RS04975	COG0083	homoserine kinase activity
AMK43_RS04980	COG1435	thymidine kinase activity
AMK43_RS04990	COG0540	Belongs to the ATCase OTCase family
AMK43_RS04995	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
AMK43_RS05000	COG0284	orotidine-5'-phosphate decarboxylase activity
AMK43_RS05010	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AMK43_RS05015	COG0017	Asparaginyl-tRNA synthetase
AMK43_RS05025	COG0758	DNA mediated transformation
AMK43_RS05030	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AMK43_RS05035	COG4974	Belongs to the 'phage' integrase family
AMK43_RS05050	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
AMK43_RS05060	COG0012	GTP binding
AMK43_RS05065	COG0668	transmembrane transport
AMK43_RS05070	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AMK43_RS05075	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AMK43_RS05120	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AMK43_RS05140	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AMK43_RS05145	COG0037	tRNA processing
AMK43_RS05150	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AMK43_RS05155	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AMK43_RS05165	COG0426	domain, Protein
AMK43_RS05170	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AMK43_RS05175	COG0693	protein deglycase activity
AMK43_RS05180	COG2001	Belongs to the MraZ family
AMK43_RS05185	COG0275	rRNA processing
AMK43_RS05200	COG1269	ATP hydrolysis coupled proton transport
AMK43_RS05205	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AMK43_RS05210	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
AMK43_RS05215	COG1527	subunit (C
AMK43_RS05270	COG0561	phosphatase activity
AMK43_RS05275	COG3682	Transcriptional regulator
AMK43_RS05280	COG2217	Heavy metal translocating P-type atpase
AMK43_RS05300	COG1217	gtp-binding protein TYPA
AMK43_RS05320	COG3339	Conserved Protein
AMK43_RS05355	COG0602	queuosine metabolic process
AMK43_RS05375	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AMK43_RS05405	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AMK43_RS05415	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AMK43_RS05420	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AMK43_RS05430	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AMK43_RS05435	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AMK43_RS05440	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AMK43_RS05445	COG0571	ribonuclease III activity
AMK43_RS05450	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AMK43_RS05455	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AMK43_RS05460	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
AMK43_RS05465	COG3872	metal-dependent enzyme
AMK43_RS05500	COG0803	Belongs to the bacterial solute-binding protein 9 family
AMK43_RS05505	COG1121	(ABC) transporter
AMK43_RS05510	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AMK43_RS05515	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AMK43_RS05525	COG0501	Belongs to the peptidase M48B family
AMK43_RS05535	COG2801	Transposase and inactivated derivatives
AMK43_RS05550	COG4783	chaperone-mediated protein folding
AMK43_RS05555	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AMK43_RS05570	COG1185	polyribonucleotide nucleotidyltransferase activity
AMK43_RS05585	COG0232	Belongs to the dGTPase family. Type 2 subfamily
AMK43_RS05590	COG0058	SHG alpha-glucan phosphorylase activity
AMK43_RS05610	COG1621	beta-fructofuranosidase activity
AMK43_RS05615	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AMK43_RS05615	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AMK43_RS05620	COG0617	tRNA 3'-terminal CCA addition
AMK43_RS05625	COG1104	cysteine desulfurase activity
AMK43_RS05640	COG0616	signal peptide processing
AMK43_RS05650	COG2195	Cleaves the N-terminal amino acid of tripeptides
AMK43_RS05655	COG0673	inositol 2-dehydrogenase activity
AMK43_RS05670	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AMK43_RS05700	COG3023	N-Acetylmuramoyl-L-alanine amidase
AMK43_RS05750	COG0481	GTPase activity
AMK43_RS05760	COG0556	nucleotide-excision repair
AMK43_RS05780	COG0728	peptidoglycan biosynthetic process
AMK43_RS05785	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AMK43_RS05790	COG0196	riboflavin kinase activity
AMK43_RS05795	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AMK43_RS05795	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AMK43_RS05810	COG1132	(ABC) transporter
AMK43_RS05815	COG1132	(ABC) transporter
AMK43_RS05825	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AMK43_RS05830	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AMK43_RS05835	COG0446	pyridine nucleotide-disulphide oxidoreductase
AMK43_RS05910	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AMK43_RS05915	COG1473	amidohydrolase
AMK43_RS05930	COG1744	ABC transporter substrate-binding protein PnrA-like
AMK43_RS05945	COG2207	Transcriptional regulator
AMK43_RS05945	COG3708	Transcriptional regulator
AMK43_RS05950	COG0018	arginyl-trna synthetase
AMK43_RS05955	COG2207	Transcriptional regulator
AMK43_RS05960	COG1288	antiporter activity
AMK43_RS05970	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AMK43_RS05975	COG2235	arginine
AMK43_RS06005	COG0534	Mate efflux family protein
AMK43_RS06015	COG4166	transmembrane transport
AMK43_RS06030	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AMK43_RS06110	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AMK43_RS06115	COG3118	belongs to the thioredoxin family
AMK43_RS06130	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AMK43_RS06140	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AMK43_RS06145	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AMK43_RS06150	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AMK43_RS06160	COG0745	RESPONSE REGULATOR receiver
AMK43_RS06165	COG0489	protein tyrosine kinase activity
AMK43_RS06170	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AMK43_RS06175	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AMK43_RS06180	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AMK43_RS06185	COG0592	DNA-directed DNA polymerase activity
AMK43_RS06190	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AMK43_RS06195	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AMK43_RS06200	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AMK43_RS06205	COG0534	Mate efflux family protein
AMK43_RS06210	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AMK43_RS06220	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AMK43_RS06225	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AMK43_RS06240	COG2843	Capsule synthesis protein
AMK43_RS06245	COG3022	response to hydroperoxide
AMK43_RS06260	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AMK43_RS06285	COG3177	Filamentation induced by cAMP protein fic
AMK43_RS06295	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AMK43_RS06300	COG1780	Probably involved in ribonucleotide reductase function
AMK43_RS06305	COG0492	ferredoxin-NADP+ reductase activity
AMK43_RS06305	COG3118	belongs to the thioredoxin family
AMK43_RS06310	COG0646	methionine synthase
AMK43_RS06310	COG1410	methionine synthase
AMK43_RS06320	COG1690	Belongs to the RtcB family
AMK43_RS06370	COG0436	Aminotransferase
AMK43_RS06380	COG1263	PTS System
AMK43_RS06380	COG2190	(PTS) system
AMK43_RS06380	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AMK43_RS06405	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AMK43_RS06410	COG1328	CTP reductase activity
AMK43_RS06425	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AMK43_RS06435	COG1079	Belongs to the binding-protein-dependent transport system permease family
AMK43_RS06440	COG4603	Belongs to the binding-protein-dependent transport system permease family
AMK43_RS06445	COG3845	ABC transporter
AMK43_RS06450	COG1744	ABC transporter substrate-binding protein PnrA-like
AMK43_RS06455	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AMK43_RS06460	COG1136	(ABC) transporter
AMK43_RS06460	COG0577	efflux transmembrane transporter activity
AMK43_RS06465	COG1136	(ABC) transporter
AMK43_RS06510	COG0151	Belongs to the GarS family
AMK43_RS06545	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AMK43_RS06550	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AMK43_RS06555	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AMK43_RS06560	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AMK43_RS06565	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AMK43_RS06570	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AMK43_RS06575	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AMK43_RS06580	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
AMK43_RS06595	COG0488	(ABC) transporter
AMK43_RS06610	COG0460	homoserine dehydrogenase
AMK43_RS06625	COG0366	Alpha amylase catalytic
AMK43_RS06650	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AMK43_RS06650	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AMK43_RS06655	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AMK43_RS06655	COG1522	sequence-specific DNA binding
AMK43_RS06665	COG4166	transmembrane transport
AMK43_RS06670	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AMK43_RS06675	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AMK43_RS06685	COG0205	6-phosphofructokinase activity
AMK43_RS06715	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AMK43_RS06720	COG0537	adenosine 5'-monophosphoramidase activity
AMK43_RS06725	COG0698	ribose 5-phosphate isomerase
AMK43_RS06730	COG0824	Thioesterase
AMK43_RS06735	COG1837	Belongs to the UPF0109 family
AMK43_RS06745	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AMK43_RS06755	COG0515	serine threonine protein kinase
AMK43_RS06755	COG2815	serine threonine protein kinase
AMK43_RS06760	COG1162	GTPase activity
AMK43_RS06765	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AMK43_RS06775	COG1293	RNA-binding protein homologous to eukaryotic snRNP
AMK43_RS06780	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AMK43_RS06790	COG0191	fructose-bisphosphate aldolase activity
AMK43_RS06800	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AMK43_RS06810	COG1663	tetraacyldisaccharide 4'-kinase activity
AMK43_RS06815	COG1481	regulation of sporulation
AMK43_RS06905	COG0582	viral genome integration into host DNA
AMK43_RS06920	COG0436	Aminotransferase
AMK43_RS06940	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
AMK43_RS06945	COG1490	D-aminoacyl-tRNA deacylase activity
AMK43_RS06950	COG0791	NLP P60 protein
AMK43_RS06975	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AMK43_RS06980	COG0601	transmembrane transport
AMK43_RS06985	COG4608	Belongs to the ABC transporter superfamily
AMK43_RS06995	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AMK43_RS06995	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AMK43_RS06995	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AMK43_RS07005	COG1349	DNA-binding transcription factor activity
AMK43_RS07010	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AMK43_RS07020	COG1064	alcohol dehydrogenase
AMK43_RS07035	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AMK43_RS07040	COG2868	ribosomal protein
AMK43_RS07045	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AMK43_RS07050	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AMK43_RS07050	COG1519	Transferase
AMK43_RS07055	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AMK43_RS07055	COG1519	Transferase
AMK43_RS07060	COG0776	regulation of translation
AMK43_RS07065	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AMK43_RS07070	COG2264	protein methyltransferase activity
AMK43_RS07075	COG1692	metallophosphoesterase
AMK43_RS07085	COG1418	mRNA catabolic process
AMK43_RS07100	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AMK43_RS07115	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AMK43_RS07115	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AMK43_RS07130	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AMK43_RS07135	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AMK43_RS07140	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AMK43_RS07145	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AMK43_RS07150	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AMK43_RS07165	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AMK43_RS07180	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AMK43_RS07185	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AMK43_RS07215	COG2226	methyltransferase
AMK43_RS07220	COG0295	cytidine deaminase activity
AMK43_RS07225	COG0813	purine-nucleoside phosphorylase activity
AMK43_RS07240	COG1051	belongs to the nudix hydrolase family
AMK43_RS07245	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
AMK43_RS07265	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AMK43_RS07275	COG1373	ATPase (AAA superfamily
AMK43_RS07290	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
AMK43_RS07295	COG1744	ABC transporter substrate-binding protein PnrA-like
AMK43_RS07300	COG1079	Belongs to the binding-protein-dependent transport system permease family
AMK43_RS07305	COG4603	Belongs to the binding-protein-dependent transport system permease family
AMK43_RS07310	COG3845	ABC transporter
AMK43_RS07320	COG0322	excinuclease ABC activity
AMK43_RS07335	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AMK43_RS07375	COG1196	nuclear chromosome segregation
AMK43_RS07390	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AMK43_RS07395	COG1215	transferase activity, transferring glycosyl groups
AMK43_RS07400	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
AMK43_RS07400	COG1215	transferase activity, transferring glycosyl groups
AMK43_RS07405	COG1442	glycosyl transferase family 8
AMK43_RS07405	COG1216	Glycosyl transferase, family 2
AMK43_RS07415	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AMK43_RS07425	COG2759	Belongs to the formate--tetrahydrofolate ligase family
AMK43_RS07430	COG0791	NLP P60 protein
AMK43_RS07495	COG0217	transcriptional regulatory protein
AMK43_RS07530	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AMK43_RS07535	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AMK43_RS07540	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AMK43_RS07565	COG0297	glycogen (starch) synthase activity
AMK43_RS07570	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AMK43_RS07575	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AMK43_RS07585	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AMK43_RS07590	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AMK43_RS07610	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AMK43_RS07615	COG1187	pseudouridine synthase activity
AMK43_RS07620	COG1605	Chorismate mutase
AMK43_RS07620	COG0077	Prephenate dehydratase
AMK43_RS07635	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AMK43_RS07645	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AMK43_RS07650	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AMK43_RS07665	COG0765	amino acid transport
AMK43_RS07670	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AMK43_RS07675	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AMK43_RS07680	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AMK43_RS07690	COG0019	diaminopimelate decarboxylase activity
AMK43_RS07700	COG1121	(ABC) transporter
AMK43_RS07710	COG0372	Belongs to the citrate synthase family
AMK43_RS07715	COG0473	3-isopropylmalate dehydrogenase activity
AMK43_RS07720	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AMK43_RS07730	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AMK43_RS07735	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AMK43_RS07750	COG0037	tRNA processing
AMK43_RS07845	COG1022	Amp-dependent synthetase and ligase
AMK43_RS07850	COG2502	aspartate--ammonia ligase
AMK43_RS07875	COG0825	malonyl-CoA metabolic process
AMK43_RS07880	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AMK43_RS07885	COG0564	pseudouridine synthase activity
AMK43_RS07890	COG0772	Belongs to the SEDS family
AMK43_RS07895	COG0612	Peptidase, M16
AMK43_RS07915	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AMK43_RS07920	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AMK43_RS07925	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AMK43_RS07930	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AMK43_RS07935	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AMK43_RS07940	COG1137	ATPase activity
AMK43_RS07950	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AMK43_RS07970	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AMK43_RS07980	COG1119	ATPase activity
AMK43_RS08005	COG0066	3-isopropylmalate dehydratase activity
AMK43_RS08010	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AMK43_RS08025	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AMK43_RS08040	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AMK43_RS08060	COG4221	oxidoreductase activity
AMK43_RS08070	COG2249	NAD(P)H dehydrogenase (quinone) activity
AMK43_RS08085	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AMK43_RS08090	COG1794	racemase activity, acting on amino acids and derivatives
AMK43_RS08095	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AMK43_RS08100	COG0440	acetolactate synthase activity
AMK43_RS08105	COG0028	Belongs to the TPP enzyme family
AMK43_RS08110	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AMK43_RS08115	COG0129	dihydroxy-acid dehydratase activity
AMK43_RS08120	COG2885	chlorophyll binding
AMK43_RS08125	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AMK43_RS08130	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AMK43_RS08135	COG1063	alcohol dehydrogenase
AMK43_RS08145	COG0516	GMP reductase activity
AMK43_RS08145	COG0517	IMP dehydrogenase activity
AMK43_RS08155	COG2195	Cleaves the N-terminal amino acid of tripeptides
AMK43_RS08175	COG1164	Oligoendopeptidase f
AMK43_RS08195	COG1151	hydroxylamine reductase activity
AMK43_RS08210	COG2252	PERMEase
AMK43_RS08225	COG1253	flavin adenine dinucleotide binding
AMK43_RS08245	COG1175	transmembrane transport
AMK43_RS08250	COG1653	transport
AMK43_RS08255	COG1609	Transcriptional regulator
AMK43_RS08265	COG0583	DNA-binding transcription factor activity
AMK43_RS08270	COG0180	Tryptophanyl-tRNA synthetase
AMK43_RS08275	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
AMK43_RS08280	COG1518	maintenance of DNA repeat elements
AMK43_RS08315	COG3958	Transketolase
AMK43_RS08320	COG3959	Transketolase, thiamine diphosphate binding domain
AMK43_RS08325	COG2211	Major facilitator Superfamily
AMK43_RS08335	COG1323	Belongs to the UPF0348 family
AMK43_RS08340	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AMK43_RS08355	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
AMK43_RS08380	COG1263	PTS System
AMK43_RS08380	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AMK43_RS08385	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AMK43_RS08390	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AMK43_RS08405	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AMK43_RS08420	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
AMK43_RS08455	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
AMK43_RS08465	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
AMK43_RS08480	COG3842	ATPase activity
AMK43_RS08500	COG0443	Heat shock 70 kDa protein
AMK43_RS08510	COG1420	regulation of RNA biosynthetic process
AMK43_RS08520	COG3716	PTS system mannose fructose sorbose family IID component
AMK43_RS08540	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AMK43_RS08550	COG2376	Dihydroxyacetone kinase
AMK43_RS08555	COG0235	Class ii aldolase
AMK43_RS08560	COG3775	system Galactitol-specific IIC component
AMK43_RS08565	COG3414	Phosphotransferase system galactitol-specific IIB component
AMK43_RS08585	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AMK43_RS08590	COG1733	regulation of RNA biosynthetic process
AMK43_RS08610	COG2824	Alkylphosphonate utilization operon protein PhnA
AMK43_RS08615	COG1902	pentaerythritol trinitrate reductase activity
AMK43_RS08630	COG1959	2 iron, 2 sulfur cluster binding
AMK43_RS08645	COG4115	mRNA cleavage
AMK43_RS08660	COG0300	oxidoreductase activity
AMK43_RS08675	COG2188	Transcriptional regulator
AMK43_RS08680	COG4221	oxidoreductase activity
AMK43_RS08685	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AMK43_RS08695	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AMK43_RS08705	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AMK43_RS08715	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
AMK43_RS08725	COG1686	Belongs to the peptidase S11 family
AMK43_RS08735	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AMK43_RS08760	COG0561	phosphatase activity
AMK43_RS08770	COG0683	leucine binding
AMK43_RS08795	COG0737	Belongs to the 5'-nucleotidase family
AMK43_RS08810	COG0142	geranyltranstransferase activity
AMK43_RS08815	COG1722	exodeoxyribonuclease VII activity
AMK43_RS08820	COG0742	ribosomal rna small subunit methyltransferase
AMK43_RS08830	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AMK43_RS08840	COG2890	protein-(glutamine-N5) methyltransferase activity
AMK43_RS08845	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AMK43_RS08850	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AMK43_RS08880	COG1704	LemA family
AMK43_RS08885	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AMK43_RS08890	COG1316	TRANSCRIPTIONal
AMK43_RS08905	COG0233	cytoplasmic translational termination
AMK43_RS08910	COG0528	UMP kinase activity
AMK43_RS08915	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AMK43_RS08920	COG0052	Belongs to the universal ribosomal protein uS2 family
AMK43_RS08940	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AMK43_RS08960	COG0805	protein transport
AMK43_RS08965	COG0672	)-iron permease
AMK43_RS08970	COG2837	iron assimilation
AMK43_RS08975	COG2822	iron ion transport
AMK43_RS08995	COG0739	heme binding
AMK43_RS09010	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AMK43_RS09015	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AMK43_RS09020	COG0363	glucosamine-6-phosphate deaminase activity
AMK43_RS09025	COG2309	aminopeptidase activity
AMK43_RS09030	COG2731	YhcH YjgK YiaL family protein
AMK43_RS09035	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
AMK43_RS09040	COG1737	Transcriptional regulator
AMK43_RS09045	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AMK43_RS09060	COG0395	ABC-type sugar transport system, permease component
AMK43_RS09065	COG1175	transmembrane transport
AMK43_RS09080	COG1059	Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine 7-oxoG) from DNA. Also nicks DNA at apurinic apyrimidinic sites (AP sites)
AMK43_RS09090	COG0606	chelatase, subunit chli
AMK43_RS09105	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AMK43_RS09120	COG0439	Biotin carboxylase
AMK43_RS09130	COG0587	DNA-directed DNA polymerase activity
AMK43_RS09135	COG0561	phosphatase activity
AMK43_RS09155	COG1012	belongs to the aldehyde dehydrogenase family
AMK43_RS09165	COG1122	ATPase activity
AMK43_RS09175	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
AMK43_RS09205	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AMK43_RS09255	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AMK43_RS09270	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AMK43_RS09275	COG1619	proteins homologs of microcin C7 resistance protein MccF
AMK43_RS09285	COG0442	prolyl-tRNA aminoacylation
AMK43_RS09300	COG2333	competence protein COMEC
AMK43_RS09300	COG0658	competence protein
AMK43_RS09310	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
AMK43_RS09310	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AMK43_RS09315	COG0655	NAD(P)H dehydrogenase (quinone) activity
AMK43_RS09340	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AMK43_RS09350	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AMK43_RS09365	COG1028	Short-chain dehydrogenase reductase Sdr
AMK43_RS09370	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AMK43_RS09375	COG0726	polysaccharide deacetylase
AMK43_RS09385	COG0018	arginyl-trna synthetase
AMK43_RS09395	COG1653	transport
AMK43_RS09400	COG1175	transmembrane transport
AMK43_RS09410	COG0673	inositol 2-dehydrogenase activity
AMK43_RS09420	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AMK43_RS09425	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AMK43_RS09460	COG1953	Uracil, thiamine, allantoin
AMK43_RS09465	COG1960	acyl-CoA dehydrogenase activity
AMK43_RS09470	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AMK43_RS09475	COG0444	Belongs to the ABC transporter superfamily
AMK43_RS09485	COG0601	transmembrane transport
AMK43_RS09500	COG1924	4 iron, 4 sulfur cluster binding
AMK43_RS09505	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
AMK43_RS09530	COG0709	Synthesizes selenophosphate from selenide and ATP
AMK43_RS09635	COG2205	protein histidine kinase activity
AMK43_RS09640	COG0745	RESPONSE REGULATOR receiver
AMK43_RS09655	COG4166	transmembrane transport
AMK43_RS09670	COG0573	inorganic phosphate transmembrane transporter activity
AMK43_RS09675	COG0581	inorganic phosphate transmembrane transporter activity
AMK43_RS09680	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AMK43_RS09710	COG2195	Cleaves the N-terminal amino acid of tripeptides
AMK43_RS09715	COG5505	Protein of unknown function (DUF819)
AMK43_RS09720	COG1115	amino acid carrier protein
AMK43_RS09735	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
AMK43_RS09760	COG3118	belongs to the thioredoxin family
AMK43_RS09765	COG1473	amidohydrolase
AMK43_RS09795	COG0716	FMN binding
AMK43_RS09800	COG2813	Specifically methylates the guanine in position
AMK43_RS09815	COG2249	NAD(P)H dehydrogenase (quinone) activity
AMK43_RS09820	COG1733	regulation of RNA biosynthetic process
AMK43_RS09830	COG1733	regulation of RNA biosynthetic process
AMK43_RS09855	COG0343	queuine tRNA-ribosyltransferase activity
AMK43_RS09860	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AMK43_RS09880	COG0511	ligase activity, forming carbon-carbon bonds
AMK43_RS09885	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AMK43_RS09890	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
AMK43_RS09895	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AMK43_RS09900	COG0242	peptide deformylase activity
AMK43_RS09905	COG5002	protein histidine kinase activity
AMK43_RS09910	COG0745	RESPONSE REGULATOR receiver
AMK43_RS09985	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AMK43_RS09990	COG2723	6-phospho-beta-galactosidase activity
AMK43_RS09995	COG0671	phosphoesterase, PA-phosphatase related
AMK43_RS10000	COG1482	cell wall glycoprotein biosynthetic process
AMK43_RS10005	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AMK43_RS10010	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMK43_RS10015	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AMK43_RS10015	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AMK43_RS10020	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AMK43_RS10020	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AMK43_RS10025	COG0785	Cytochrome C biogenesis protein
AMK43_RS10030	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AMK43_RS10035	COG0745	RESPONSE REGULATOR receiver
AMK43_RS10040	COG2972	Histidine kinase
AMK43_RS10045	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AMK43_RS10050	COG0254	rRNA binding
AMK43_RS10055	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AMK43_RS10060	COG0280	phosphate acetyltransferase
AMK43_RS10065	COG0552	protein localization to endoplasmic reticulum
AMK43_RS10070	COG1214	PFAM Peptidase M22, glycoprotease
AMK43_RS10075	COG0802	atpase or kinase
AMK43_RS10080	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AMK43_RS10080	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
AMK43_RS10085	COG2217	Heavy metal translocating P-type atpase
AMK43_RS10090	COG0640	Transcriptional regulator
AMK43_RS10095	COG0569	domain protein
AMK43_RS10100	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AMK43_RS10115	COG1160	GTP binding
AMK43_RS10120	COG1739	Uncharacterized protein family UPF0029
AMK43_RS10130	COG1994	Peptidase M50
AMK43_RS10135	COG1185	polyribonucleotide nucleotidyltransferase activity
AMK43_RS10135	COG0539	negative regulation of cytoplasmic translation
AMK43_RS10135	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AMK43_RS10170	COG0670	Belongs to the BI1 family
AMK43_RS10175	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AMK43_RS10185	COG0860	N-Acetylmuramoyl-L-alanine amidase
AMK43_RS10185	COG1388	LysM domain
AMK43_RS10190	COG1673	EVE domain
AMK43_RS10205	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AMK43_RS10210	COG3693	PFAM glycoside hydrolase, family 10
AMK43_RS10210	COG3507	Belongs to the glycosyl hydrolase 43 family
AMK43_RS10210	COG2382	esterase
AMK43_RS10215	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AMK43_RS10215	COG1263	PTS System
AMK43_RS10225	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AMK43_RS10240	COG1447	Phosphotransferase system cellobiose-specific component IIA
AMK43_RS10245	COG1486	melibiose metabolic process
AMK43_RS10250	COG1737	Transcriptional regulator
AMK43_RS10325	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AMK43_RS10340	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AMK43_RS10345	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AMK43_RS10355	COG0626	cystathionine gamma-synthase activity
AMK43_RS10370	COG2801	Transposase and inactivated derivatives
AMK43_RS10380	COG1396	sequence-specific DNA binding
AMK43_RS10405	COG3620	sequence-specific DNA binding
AMK43_RS10430	COG1686	Belongs to the peptidase S11 family
AMK43_RS10435	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AMK43_RS10440	COG0632	four-way junction helicase activity
AMK43_RS10445	COG0217	transcriptional regulatory protein
AMK43_RS10455	COG0383	alpha-mannosidase activity
AMK43_RS10460	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AMK43_RS10465	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AMK43_RS10470	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AMK43_RS10470	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AMK43_RS10470	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AMK43_RS10475	COG3711	transcriptional antiterminator
AMK43_RS10475	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AMK43_RS10495	COG0736	holo-[acyl-carrier-protein] synthase activity
AMK43_RS10500	COG0084	hydrolase, TatD family'
AMK43_RS10520	COG1854	S-ribosylhomocysteine lyase activity
AMK43_RS10530	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AMK43_RS10540	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AMK43_RS10545	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AMK43_RS10555	COG1475	DNA binding
AMK43_RS10565	COG0357	Ribosomal RNA small subunit methyltransferase G
AMK43_RS10570	COG0445	tRNA wobble uridine modification
AMK43_RS10575	COG0778	Nitroreductase
AMK43_RS10580	COG4166	transmembrane transport
AMK43_RS10585	COG4608	Belongs to the ABC transporter superfamily
AMK43_RS10590	COG0444	Belongs to the ABC transporter superfamily
AMK43_RS10595	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AMK43_RS10600	COG0601	transmembrane transport
AMK43_RS10605	COG1132	(ABC) transporter
AMK43_RS10615	COG1045	serine acetyltransferase
AMK43_RS10620	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AMK43_RS10635	COG0737	Belongs to the 5'-nucleotidase family
AMK43_RS10645	COG3118	belongs to the thioredoxin family
AMK43_RS10650	COG0492	ferredoxin-NADP+ reductase activity
AMK43_RS10665	COG3545	Serine hydrolase
AMK43_RS10670	COG1733	regulation of RNA biosynthetic process
AMK43_RS10695	COG1362	aminopeptidase activity
AMK43_RS10700	COG1160	GTP binding
AMK43_RS10725	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AMK43_RS10760	COG0235	Class ii aldolase
AMK43_RS10765	COG3623	hexulose-6-phosphate isomerase
AMK43_RS10805	COG2514	catechol 2,3-dioxygenase activity
AMK43_RS10820	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AMK43_RS10825	COG1968	undecaprenyl-diphosphatase activity
AMK43_RS10835	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AMK43_RS10840	COG0557	exoribonuclease II activity
AMK43_RS10845	COG1713	HD superfamily hydrolase involved in NAD metabolism
AMK43_RS10855	COG0860	N-Acetylmuramoyl-L-alanine amidase
AMK43_RS10860	COG1862	Preprotein translocase
AMK43_RS10885	COG1489	DNA binding
AMK43_RS10890	COG0602	queuosine metabolic process
AMK43_RS10920	COG1176	ABC-type spermidine putrescine transport system, permease component I
AMK43_RS10925	COG3842	ATPase activity
AMK43_RS10930	COG0519	Catalyzes the synthesis of GMP from XMP
AMK43_RS10930	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AMK43_RS10990	COG1309	transcriptional regulator
AMK43_RS10995	COG1132	(ABC) transporter
AMK43_RS11000	COG1132	(ABC) transporter
AMK43_RS11005	COG1129	ABC transporter
AMK43_RS11025	COG1061	Type III restriction enzyme res subunit
AMK43_RS11045	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AMK43_RS11055	COG0167	dihydroorotate dehydrogenase activity
AMK43_RS11065	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AMK43_RS11070	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AMK43_RS11075	COG0110	maltose O-acetyltransferase activity
AMK43_RS11085	COG0438	transferase activity, transferring glycosyl groups
AMK43_RS11125	COG2246	polysaccharide biosynthetic process
AMK43_RS11175	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
AMK43_RS11180	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AMK43_RS11185	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
AMK43_RS11185	COG0662	Cupin 2, conserved barrel domain protein
AMK43_RS11195	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AMK43_RS11200	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AMK43_RS11215	COG2088	sporulation resulting in formation of a cellular spore
AMK43_RS11220	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AMK43_RS11235	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AMK43_RS11240	COG4658	electron transport chain
AMK43_RS11245	COG4656	Part of a membrane complex involved in electron transport
AMK43_RS11250	COG1477	protein flavinylation
AMK43_RS11260	COG1132	(ABC) transporter
AMK43_RS11265	COG0726	polysaccharide deacetylase
AMK43_RS11290	COG1216	Glycosyl transferase, family 2
AMK43_RS11295	COG1442	glycosyl transferase family 8
AMK43_RS11295	COG1216	Glycosyl transferase, family 2
AMK43_RS11390	COG1131	(ABC) transporter
AMK43_RS11405	COG0193	aminoacyl-tRNA hydrolase activity
AMK43_RS11410	COG0445	tRNA wobble uridine modification
AMK43_RS11435	COG2501	S4 domain