locus-tag	class	description
I6H90_RS00005	COG0366	Alpha amylase catalytic
I6H90_RS00015	COG0366	Alpha amylase catalytic
I6H90_RS00025	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6H90_RS00040	COG1609	Transcriptional regulator
I6H90_RS00050	COG3534	alpha-L-arabinofuranosidase
I6H90_RS00060	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6H90_RS00060	COG2207	Transcriptional regulator
I6H90_RS00080	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
I6H90_RS00085	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I6H90_RS00095	COG1609	Transcriptional regulator
I6H90_RS00100	COG2190	(PTS) system
I6H90_RS00100	COG2211	Major facilitator Superfamily
I6H90_RS00125	COG1472	Belongs to the glycosyl hydrolase 3 family
I6H90_RS00150	COG5039	Polysaccharide pyruvyl transferase
I6H90_RS00155	COG2814	Major facilitator Superfamily
I6H90_RS00170	COG2261	transglycosylase associated protein
I6H90_RS00195	COG2261	transglycosylase associated protein
I6H90_RS00205	COG1028	Short-chain dehydrogenase reductase Sdr
I6H90_RS00210	COG0366	Alpha amylase catalytic
I6H90_RS00210	COG5263	repeat protein
I6H90_RS00235	COG2160	L-arabinose isomerase activity
I6H90_RS00240	COG1609	Transcriptional regulator
I6H90_RS00270	COG1874	Beta-galactosidase
I6H90_RS00285	COG0667	Aldo Keto reductase
I6H90_RS00295	COG1045	serine acetyltransferase
I6H90_RS00300	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6H90_RS00305	COG0583	DNA-binding transcription factor activity
I6H90_RS00315	COG1136	(ABC) transporter
I6H90_RS00320	COG5002	protein histidine kinase activity
I6H90_RS00325	COG0745	RESPONSE REGULATOR receiver
I6H90_RS00330	COG0693	protein deglycase activity
I6H90_RS00350	COG1609	Transcriptional regulator
I6H90_RS00360	COG2814	Major facilitator Superfamily
I6H90_RS00365	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I6H90_RS00370	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I6H90_RS00380	COG0307	riboflavin synthase, alpha
I6H90_RS00385	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6H90_RS00385	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6H90_RS00400	COG0493	'glutamate synthase
I6H90_RS00405	COG0070	glutamate synthase
I6H90_RS00405	COG0069	glutamate synthase activity
I6H90_RS00405	COG0067	glutamate synthase
I6H90_RS00420	COG1033	growth of symbiont in host cell
I6H90_RS00420	COG2409	Drug exporters of the RND superfamily
I6H90_RS00435	COG0577	efflux transmembrane transporter activity
I6H90_RS00440	COG0415	Belongs to the DNA photolyase family
I6H90_RS00445	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I6H90_RS00465	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6H90_RS00470	COG1121	(ABC) transporter
I6H90_RS00485	COG2877	3-deoxy-8-phosphooctulonate synthase activity
I6H90_RS00490	COG0517	IMP dehydrogenase activity
I6H90_RS00490	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I6H90_RS00510	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6H90_RS00515	COG1609	Transcriptional regulator
I6H90_RS00540	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6H90_RS00545	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6H90_RS00550	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I6H90_RS00555	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I6H90_RS00560	COG0460	homoserine dehydrogenase
I6H90_RS00565	COG0083	homoserine kinase activity
I6H90_RS00570	COG0527	aspartate kinase activity
I6H90_RS00580	COG0252	asparaginase activity
I6H90_RS00585	COG1381	Involved in DNA repair and RecF pathway recombination
I6H90_RS00590	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I6H90_RS00600	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
I6H90_RS00605	COG1702	phosphate starvation-inducible protein PhoH
I6H90_RS00610	COG0004	ammonium transporteR
I6H90_RS00620	COG0587	DNA-directed DNA polymerase activity
I6H90_RS00635	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6H90_RS00640	COG2384	SAM-dependent methyltransferase
I6H90_RS00655	COG1122	ATPase activity
I6H90_RS00665	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I6H90_RS00670	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I6H90_RS00675	COG4479	Belongs to the UPF0346 family
I6H90_RS00685	COG2755	lipolytic protein G-D-S-L family
I6H90_RS00695	COG1957	nucleoside hydrolase
I6H90_RS00700	COG1307	EDD domain protein, DegV family
I6H90_RS00710	COG0617	tRNA 3'-terminal CCA addition
I6H90_RS00730	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
I6H90_RS00735	COG1169	isochorismate synthase
I6H90_RS00740	COG0351	phosphomethylpyrimidine kinase
I6H90_RS00750	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I6H90_RS00755	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6H90_RS00780	COG0584	glycerophosphoryl diester phosphodiesterase
I6H90_RS00785	COG2267	carboxylic ester hydrolase activity
I6H90_RS00795	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6H90_RS00810	COG0095	Lipoate-protein ligase
I6H90_RS00820	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6H90_RS00840	COG4717	serine-type aminopeptidase activity
I6H90_RS00845	COG0420	3'-5' exonuclease activity
I6H90_RS00850	COG0138	bifunctional purine biosynthesis protein purh
I6H90_RS00855	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I6H90_RS00860	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I6H90_RS00870	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6H90_RS00880	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6H90_RS00885	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
I6H90_RS00890	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I6H90_RS00895	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I6H90_RS00900	COG0174	glutamine synthetase
I6H90_RS00905	COG0789	Transcriptional regulator
I6H90_RS00915	COG3764	Sortase (surface protein transpeptidase)
I6H90_RS00920	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6H90_RS00920	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6H90_RS00940	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6H90_RS00945	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6H90_RS00950	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6H90_RS00960	COG0494	nUDIX hydrolase
I6H90_RS00965	COG1278	Cold shock
I6H90_RS00970	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I6H90_RS00975	COG2759	Belongs to the formate--tetrahydrofolate ligase family
I6H90_RS00980	COG0151	Belongs to the GarS family
I6H90_RS00985	COG0667	Aldo Keto reductase
I6H90_RS00995	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6H90_RS01000	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6H90_RS01015	COG1744	ABC transporter substrate-binding protein PnrA-like
I6H90_RS01020	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
I6H90_RS01020	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6H90_RS01035	COG2176	DNA-directed DNA polymerase activity
I6H90_RS01040	COG0442	prolyl-tRNA aminoacylation
I6H90_RS01045	COG0750	zinc metalloprotease
I6H90_RS01050	COG4589	Belongs to the CDS family
I6H90_RS01055	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6H90_RS01060	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6H90_RS01065	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
I6H90_RS01075	COG2239	Acts as a magnesium transporter
I6H90_RS01080	COG0564	pseudouridine synthase activity
I6H90_RS01085	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I6H90_RS01090	COG2357	RelA SpoT domain protein
I6H90_RS01100	COG1940	carbohydrate kinase activity
I6H90_RS01110	COG0705	Rhomboid family
I6H90_RS01115	COG3557	Belongs to the UPF0374 family
I6H90_RS01120	COG2137	regulation of response to DNA damage stimulus
I6H90_RS01125	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I6H90_RS01130	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6H90_RS01135	COG1473	amidohydrolase
I6H90_RS01140	COG2171	N-acyltransferase activity
I6H90_RS01150	COG3001	Fructosamine kinase
I6H90_RS01160	COG0586	Pfam SNARE associated Golgi protein
I6H90_RS01165	COG1113	amino acid transport
I6H90_RS01170	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I6H90_RS01175	COG1674	ftsk spoiiie
I6H90_RS01175	COG1280	lysine exporter protein (LysE YggA)
I6H90_RS01190	COG0628	permease
I6H90_RS01195	COG2706	6-phosphogluconolactonase activity
I6H90_RS01200	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6H90_RS01210	COG3599	regulation of cell shape
I6H90_RS01215	COG4474	Belongs to the UPF0398 family
I6H90_RS01225	COG3331	DNA recombination
I6H90_RS01245	COG0517	IMP dehydrogenase activity
I6H90_RS01245	COG0516	GMP reductase activity
I6H90_RS01250	COG0516	GMP reductase activity
I6H90_RS01250	COG0517	IMP dehydrogenase activity
I6H90_RS01255	COG3237	CsbD-like
I6H90_RS01265	COG1942	4-Oxalocrotonate Tautomerase
I6H90_RS01270	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I6H90_RS01275	COG0501	Belongs to the peptidase M48B family
I6H90_RS01280	COG1704	LemA family
I6H90_RS01295	COG2244	polysaccharide biosynthetic process
I6H90_RS01300	COG0495	leucyl-tRNA aminoacylation
I6H90_RS01305	COG0671	phosphoesterase, PA-phosphatase related
I6H90_RS01315	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6H90_RS01325	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
I6H90_RS01330	COG1126	abc transporter atp-binding protein
I6H90_RS01335	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6H90_RS01355	COG4684	Psort location CytoplasmicMembrane, score
I6H90_RS01365	COG4684	Psort location CytoplasmicMembrane, score
I6H90_RS01370	COG1136	(ABC) transporter
I6H90_RS01375	COG0577	efflux transmembrane transporter activity
I6H90_RS01380	COG1970	mechanosensitive ion channel activity
I6H90_RS01385	COG1428	Deoxynucleoside kinase
I6H90_RS01390	COG0632	four-way junction helicase activity
I6H90_RS01395	COG0584	glycerophosphoryl diester phosphodiesterase
I6H90_RS01400	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
I6H90_RS01410	COG2255	four-way junction helicase activity
I6H90_RS01420	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
I6H90_RS01425	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I6H90_RS01430	COG1719	4-vinyl reductase, 4VR
I6H90_RS01435	COG0335	large ribosomal subunit rRNA binding
I6H90_RS01440	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6H90_RS01450	COG1609	Transcriptional regulator
I6H90_RS01455	COG1063	alcohol dehydrogenase
I6H90_RS01470	COG0492	ferredoxin-NADP+ reductase activity
I6H90_RS01475	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6H90_RS01480	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I6H90_RS01485	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
I6H90_RS01490	COG1950	PFAM Membrane protein of
I6H90_RS01500	COG0704	Plays a role in the regulation of phosphate uptake
I6H90_RS01505	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6H90_RS01510	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6H90_RS01515	COG0581	inorganic phosphate transmembrane transporter activity
I6H90_RS01520	COG0573	inorganic phosphate transmembrane transporter activity
I6H90_RS01535	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I6H90_RS01540	COG0745	RESPONSE REGULATOR receiver
I6H90_RS01545	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
I6H90_RS01550	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6H90_RS01555	COG1426	Protein conserved in bacteria
I6H90_RS01560	COG0612	Peptidase, M16
I6H90_RS01565	COG0612	Peptidase, M16
I6H90_RS01575	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6H90_RS01585	COG0765	amino acid transport
I6H90_RS01600	COG1077	Cell shape determining protein MreB Mrl
I6H90_RS01610	COG0542	response to heat
I6H90_RS01625	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I6H90_RS01640	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6H90_RS01645	COG1705	Flagellar rod assembly protein muramidase FlgJ
I6H90_RS01650	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I6H90_RS01655	COG4988	ABC transporter
I6H90_RS01660	COG1294	oxidase, subunit
I6H90_RS01665	COG1271	oxidase subunit
I6H90_RS01670	COG3906	Belongs to the UPF0473 family
I6H90_RS01675	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I6H90_RS01680	COG4472	Bacterial protein of unknown function (DUF965)
I6H90_RS01685	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6H90_RS01695	COG0531	amino acid
I6H90_RS01710	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
I6H90_RS01715	COG1737	Transcriptional regulator
I6H90_RS01720	COG3527	Alpha-acetolactate decarboxylase
I6H90_RS01735	COG2814	Major facilitator Superfamily
I6H90_RS01745	COG1609	Transcriptional regulator
I6H90_RS01765	COG0561	phosphatase activity
I6H90_RS01770	COG3091	SprT-like family
I6H90_RS01775	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6H90_RS01780	COG0416	fatty acid biosynthetic process
I6H90_RS01785	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I6H90_RS01810	COG1484	DNA-dependent DNA replication
I6H90_RS01820	COG0237	dephospho-CoA kinase activity
I6H90_RS01830	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I6H90_RS01835	COG0513	Belongs to the DEAD box helicase family
I6H90_RS01840	COG0673	inositol 2-dehydrogenase activity
I6H90_RS01850	COG2309	aminopeptidase activity
I6H90_RS01855	COG0028	Belongs to the TPP enzyme family
I6H90_RS01860	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
I6H90_RS01865	COG0322	excinuclease ABC activity
I6H90_RS01870	COG0504	CTP synthase activity
I6H90_RS01875	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
I6H90_RS01875	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
I6H90_RS01885	COG1268	BioY protein
I6H90_RS01890	COG1113	amino acid transport
I6H90_RS01900	COG3343	RNA polymerase activity
I6H90_RS01910	COG1078	dGTPase activity
I6H90_RS01915	COG2188	Transcriptional regulator
I6H90_RS01920	COG0366	Alpha amylase catalytic
I6H90_RS01925	COG2190	(PTS) system
I6H90_RS01925	COG1263	PTS System
I6H90_RS01925	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6H90_RS01935	COG2936	dipeptidyl-peptidase activity
I6H90_RS01945	COG0308	aminopeptidase N
I6H90_RS01955	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6H90_RS01975	COG1609	Transcriptional regulator
I6H90_RS01985	COG4493	Belongs to the UPF0637 family
I6H90_RS02025	COG1012	belongs to the aldehyde dehydrogenase family
I6H90_RS02030	COG0352	thiamine-phosphate diphosphorylase activity
I6H90_RS02035	COG0351	phosphomethylpyrimidine kinase
I6H90_RS02040	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
I6H90_RS02050	COG0411	ABC transporter
I6H90_RS02060	COG0559	Belongs to the binding-protein-dependent transport system permease family
I6H90_RS02100	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6H90_RS02105	COG4975	Glucose uptake
I6H90_RS02115	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6H90_RS02140	COG4537	Required for transformation and DNA binding
I6H90_RS02150	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6H90_RS02155	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I6H90_RS02160	COG2131	deaminase
I6H90_RS02165	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
I6H90_RS02170	COG2003	Belongs to the UPF0758 family
I6H90_RS02175	COG2814	Major facilitator Superfamily
I6H90_RS02195	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6H90_RS02200	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6H90_RS02205	COG0254	rRNA binding
I6H90_RS02210	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I6H90_RS02215	COG0072	phenylalanine-tRNA ligase activity
I6H90_RS02215	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6H90_RS02220	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
I6H90_RS02225	COG1733	regulation of RNA biosynthetic process
I6H90_RS02255	COG0765	amino acid transport
I6H90_RS02260	COG1126	abc transporter atp-binding protein
I6H90_RS02265	COG0765	amino acid transport
I6H90_RS02270	COG1744	ABC transporter substrate-binding protein PnrA-like
I6H90_RS02305	COG1464	Belongs to the NlpA lipoprotein family
I6H90_RS02315	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6H90_RS02325	COG2188	Transcriptional regulator
I6H90_RS02335	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I6H90_RS02355	COG0477	Major facilitator Superfamily
I6H90_RS02380	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6H90_RS02385	COG2252	PERMEase
I6H90_RS02395	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I6H90_RS02400	COG0217	transcriptional regulatory protein
I6H90_RS02425	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I6H90_RS02430	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
I6H90_RS02435	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6H90_RS02445	COG0037	tRNA processing
I6H90_RS02455	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I6H90_RS02460	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6H90_RS02465	COG0193	aminoacyl-tRNA hydrolase activity
I6H90_RS02475	COG0740	serine-type endopeptidase activity
I6H90_RS02480	COG1481	regulation of sporulation
I6H90_RS02485	COG0391	Required for morphogenesis under gluconeogenic growth conditions
I6H90_RS02490	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I6H90_RS02495	COG0556	nucleotide-excision repair
I6H90_RS02500	COG1368	sulfuric ester hydrolase activity
I6H90_RS02520	COG0438	transferase activity, transferring glycosyl groups
I6H90_RS02525	COG1132	(ABC) transporter
I6H90_RS02530	COG1132	(ABC) transporter
I6H90_RS02545	COG0406	alpha-ribazole phosphatase activity
I6H90_RS02560	COG0392	lysyltransferase activity
I6H90_RS02560	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
I6H90_RS02570	COG1862	Preprotein translocase
I6H90_RS02575	COG0343	queuine tRNA-ribosyltransferase activity
I6H90_RS02580	COG2814	Major facilitator Superfamily
I6H90_RS02585	COG1126	abc transporter atp-binding protein
I6H90_RS02590	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6H90_RS02595	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6H90_RS02600	COG1126	abc transporter atp-binding protein
I6H90_RS02605	COG0765	amino acid transport
I6H90_RS02610	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6H90_RS02615	COG0765	amino acid transport
I6H90_RS02650	COG4152	abc transporter atp-binding protein
I6H90_RS02670	COG3448	diguanylate cyclase activity
I6H90_RS02670	COG4175	Glycine betaine
I6H90_RS02680	COG0166	Belongs to the GPI family
I6H90_RS02685	COG0363	glucosamine-6-phosphate deaminase activity
I6H90_RS02695	COG2205	protein histidine kinase activity
I6H90_RS02700	COG0745	RESPONSE REGULATOR receiver
I6H90_RS02710	COG0012	GTP binding
I6H90_RS02715	COG4481	Protein conserved in bacteria
I6H90_RS02720	COG1475	DNA binding
I6H90_RS02725	COG1192	Involved in chromosome partitioning
I6H90_RS02730	COG0357	Ribosomal RNA small subunit methyltransferase G
I6H90_RS02735	COG1957	nucleoside hydrolase
I6H90_RS02750	COG0640	Transcriptional regulator
I6H90_RS02760	COG1914	H( )-stimulated, divalent metal cation uptake system
I6H90_RS02770	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I6H90_RS02795	COG1316	TRANSCRIPTIONal
I6H90_RS02800	COG0577	efflux transmembrane transporter activity
I6H90_RS02800	COG1136	(ABC) transporter
I6H90_RS02810	COG0640	Transcriptional regulator
I6H90_RS02815	COG0768	penicillin binding
I6H90_RS02825	COG3103	Sh3 type 3 domain protein
I6H90_RS02825	COG0791	NLP P60 protein
I6H90_RS02825	COG1388	LysM domain
I6H90_RS02840	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6H90_RS02845	COG0525	valine-tRNA ligase activity
I6H90_RS02865	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
I6H90_RS02870	COG0439	Biotin carboxylase
I6H90_RS02885	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6H90_RS02890	COG1028	Short-chain dehydrogenase reductase Sdr
I6H90_RS02895	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I6H90_RS02905	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6H90_RS02910	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6H90_RS02920	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6H90_RS02940	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6H90_RS02945	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6H90_RS02955	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
I6H90_RS02955	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
I6H90_RS02960	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6H90_RS02960	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6H90_RS02965	COG1418	mRNA catabolic process
I6H90_RS02975	COG0492	ferredoxin-NADP+ reductase activity
I6H90_RS02985	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
I6H90_RS02990	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I6H90_RS02995	COG1428	Deoxynucleoside kinase
I6H90_RS03010	COG1940	carbohydrate kinase activity
I6H90_RS03015	COG1621	beta-fructofuranosidase activity
I6H90_RS03025	COG1609	Transcriptional regulator
I6H90_RS03040	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6H90_RS03055	COG0470	DNA polymerase III
I6H90_RS03060	COG3870	Protein conserved in bacteria
I6H90_RS03065	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I6H90_RS03075	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I6H90_RS03080	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I6H90_RS03095	COG0590	tRNA wobble adenosine to inosine editing
I6H90_RS03100	COG2813	Specifically methylates the guanine in position
I6H90_RS03105	COG0222	ribosome binding
I6H90_RS03110	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I6H90_RS03115	COG0081	regulation of translation
I6H90_RS03120	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I6H90_RS03135	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6H90_RS03145	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6H90_RS03155	COG0772	Belongs to the SEDS family
I6H90_RS03165	COG1077	Cell shape determining protein MreB Mrl
I6H90_RS03180	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I6H90_RS03195	COG1780	Probably involved in ribonucleotide reductase function
I6H90_RS03200	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6H90_RS03205	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6H90_RS03210	COG1253	flavin adenine dinucleotide binding
I6H90_RS03215	COG0588	phosphoglycerate mutase activity
I6H90_RS03230	COG1040	competence protein
I6H90_RS03235	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
I6H90_RS03240	COG1739	Uncharacterized protein family UPF0029
I6H90_RS03250	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
I6H90_RS03265	COG0148	phosphopyruvate hydratase activity
I6H90_RS03270	COG0149	triose-phosphate isomerase activity
I6H90_RS03295	COG1902	pentaerythritol trinitrate reductase activity
I6H90_RS03300	COG0583	DNA-binding transcription factor activity
I6H90_RS03305	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I6H90_RS03310	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I6H90_RS03320	COG0101	tRNA pseudouridine synthase activity
I6H90_RS03325	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
I6H90_RS03330	COG1122	ATPase activity
I6H90_RS03335	COG1122	ATPase activity
I6H90_RS03345	COG0142	geranyltranstransferase activity
I6H90_RS03350	COG0203	ribosomal protein L17
I6H90_RS03355	COG0202	RNA polymerase activity
I6H90_RS03360	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
I6H90_RS03365	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I6H90_RS03370	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I6H90_RS03375	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I6H90_RS03380	COG0563	adenylate kinase activity
I6H90_RS03390	COG0200	Binds to the 23S rRNA
I6H90_RS03395	COG1841	ribosomal large subunit assembly
I6H90_RS03400	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I6H90_RS03405	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
I6H90_RS03410	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
I6H90_RS03415	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I6H90_RS03420	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
I6H90_RS03425	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
I6H90_RS03430	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
I6H90_RS03435	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I6H90_RS03440	COG0255	Belongs to the universal ribosomal protein uL29 family
I6H90_RS03445	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I6H90_RS03450	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
I6H90_RS03455	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
I6H90_RS03460	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I6H90_RS03465	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
I6H90_RS03470	COG0089	rRNA binding
I6H90_RS03475	COG0088	Forms part of the polypeptide exit tunnel
I6H90_RS03480	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I6H90_RS03485	COG0051	transcription antitermination factor activity, RNA binding
I6H90_RS03495	COG1177	transmembrane transport
I6H90_RS03500	COG1177	transmembrane transport
I6H90_RS03505	COG3842	ATPase activity
I6H90_RS03510	COG2807	transmembrane transport
I6H90_RS03515	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I6H90_RS03520	COG0049	tRNA binding
I6H90_RS03525	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I6H90_RS03535	COG0542	response to heat
I6H90_RS03540	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
I6H90_RS03545	COG0653	protein targeting
I6H90_RS03550	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I6H90_RS03650	COG0215	cysteine-tRNA ligase activity
I6H90_RS03655	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6H90_RS03660	COG1309	transcriptional regulator
I6H90_RS03680	COG0756	dUTP diphosphatase activity
I6H90_RS03690	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
I6H90_RS03725	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6H90_RS03730	COG1012	belongs to the aldehyde dehydrogenase family
I6H90_RS03730	COG1454	alcohol dehydrogenase
I6H90_RS03745	COG0351	phosphomethylpyrimidine kinase
I6H90_RS03750	COG4720	Psort location CytoplasmicMembrane, score
I6H90_RS03760	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
I6H90_RS03765	COG1126	abc transporter atp-binding protein
I6H90_RS03770	COG0765	amino acid transport
I6H90_RS03775	COG0765	amino acid transport
I6H90_RS03780	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6H90_RS03795	COG1968	undecaprenyl-diphosphatase activity
I6H90_RS03810	COG2115	Belongs to the xylose isomerase family
I6H90_RS03825	COG1272	protein, Hemolysin III
I6H90_RS03830	COG1307	EDD domain protein, DegV family
I6H90_RS03835	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I6H90_RS03840	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I6H90_RS03850	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6H90_RS03855	COG1126	abc transporter atp-binding protein
I6H90_RS03865	COG0765	amino acid transport
I6H90_RS03870	COG1464	Belongs to the NlpA lipoprotein family
I6H90_RS03880	COG0531	amino acid
I6H90_RS03885	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
I6H90_RS03890	COG3118	belongs to the thioredoxin family
I6H90_RS03895	COG1473	amidohydrolase
I6H90_RS03900	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6H90_RS03905	COG1126	abc transporter atp-binding protein
I6H90_RS03910	COG0765	amino acid transport
I6H90_RS03915	COG0456	acetyltransferase
I6H90_RS03940	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6H90_RS03950	COG0463	Glycosyl transferase, family 2
I6H90_RS03955	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I6H90_RS03965	COG1131	(ABC) transporter
I6H90_RS03980	COG0351	phosphomethylpyrimidine kinase
I6H90_RS04035	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6H90_RS04050	COG1396	sequence-specific DNA binding
I6H90_RS04060	COG4120	Belongs to the binding-protein-dependent transport system permease family
I6H90_RS04075	COG1079	Belongs to the binding-protein-dependent transport system permease family
I6H90_RS04080	COG4603	Belongs to the binding-protein-dependent transport system permease family
I6H90_RS04085	COG3845	ABC transporter
I6H90_RS04120	COG0738	Major facilitator superfamily
I6H90_RS04125	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6H90_RS04130	COG0569	domain protein
I6H90_RS04145	COG1881	PFAM PEBP family protein
I6H90_RS04150	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I6H90_RS04155	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
I6H90_RS04160	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6H90_RS04165	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6H90_RS04175	COG0656	L-ascorbic acid biosynthetic process
I6H90_RS04185	COG1131	(ABC) transporter
I6H90_RS04195	COG1131	(ABC) transporter
I6H90_RS04200	COG1725	Transcriptional regulator
I6H90_RS04210	COG2217	Heavy metal translocating P-type atpase
I6H90_RS04215	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6H90_RS04220	COG0564	pseudouridine synthase activity
I6H90_RS04230	COG0438	transferase activity, transferring glycosyl groups
I6H90_RS04235	COG1368	sulfuric ester hydrolase activity
I6H90_RS04255	COG0647	UMP catabolic process
I6H90_RS04260	COG2814	Major facilitator Superfamily
I6H90_RS04360	COG0436	Aminotransferase
I6H90_RS04365	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6H90_RS04370	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
I6H90_RS04385	COG1073	alpha beta
I6H90_RS04415	COG0386	Belongs to the glutathione peroxidase family
I6H90_RS04425	COG0187	DNA topoisomerase II activity
I6H90_RS04430	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I6H90_RS04440	COG0592	DNA-directed DNA polymerase activity
I6H90_RS04445	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I6H90_RS04465	COG0561	phosphatase activity
I6H90_RS04470	COG2084	Dehydrogenase
I6H90_RS04480	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6H90_RS04490	COG0230	Belongs to the bacterial ribosomal protein bL34 family
I6H90_RS04495	COG0594	ribonuclease P activity
I6H90_RS04500	COG0706	membrane insertase activity
I6H90_RS04520	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6H90_RS04525	COG0583	DNA-binding transcription factor activity
I6H90_RS04530	COG2855	membrane
I6H90_RS04560	COG1136	(ABC) transporter
I6H90_RS04565	COG0577	efflux transmembrane transporter activity
I6H90_RS04580	COG1983	PspC domain protein
I6H90_RS04595	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I6H90_RS04610	COG2151	metal-sulfur cluster biosynthetic enzyme
I6H90_RS04615	COG0129	dihydroxy-acid dehydratase activity
I6H90_RS04625	COG0396	ATPase activity
I6H90_RS04630	COG0719	Fe-S assembly protein
I6H90_RS04635	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6H90_RS04645	COG0719	Fe-S assembly protein
I6H90_RS04650	COG2151	metal-sulfur cluster biosynthetic enzyme
I6H90_RS04660	COG0473	3-isopropylmalate dehydrogenase activity
I6H90_RS04665	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I6H90_RS04670	COG0066	3-isopropylmalate dehydratase activity
I6H90_RS04675	COG0477	Major facilitator Superfamily
I6H90_RS04700	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
I6H90_RS04710	COG0318	PFAM AMP-dependent synthetase and ligase
I6H90_RS04715	COG2226	methyltransferase
I6H90_RS04720	COG0803	Belongs to the bacterial solute-binding protein 9 family
I6H90_RS04730	COG1686	Belongs to the peptidase S11 family
I6H90_RS04740	COG2814	Major facilitator Superfamily
I6H90_RS04750	COG0667	Aldo Keto reductase
I6H90_RS04760	COG0667	Aldo Keto reductase
I6H90_RS04770	COG1902	pentaerythritol trinitrate reductase activity
I6H90_RS04780	COG1757	Na H antiporter
I6H90_RS04810	COG0561	phosphatase activity
I6H90_RS04845	COG3623	hexulose-6-phosphate isomerase
I6H90_RS04920	COG0514	ATP-dependent DNA helicase (RecQ)
I6H90_RS04930	COG4720	Psort location CytoplasmicMembrane, score
I6H90_RS04935	COG1122	ATPase activity
I6H90_RS04945	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6H90_RS04950	COG0360	Binds together with S18 to 16S ribosomal RNA
I6H90_RS04955	COG0629	single-stranded DNA binding
I6H90_RS04960	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I6H90_RS04970	COG0359	binds to the 23S rRNA
I6H90_RS04975	COG0305	Participates in initiation and elongation during chromosome replication
I6H90_RS04985	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6H90_RS04990	COG2188	Transcriptional regulator
I6H90_RS04995	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
I6H90_RS05000	COG1119	ATPase activity
I6H90_RS05005	COG0028	Belongs to the TPP enzyme family
I6H90_RS05015	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
I6H90_RS05020	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6H90_RS05030	COG0473	3-isopropylmalate dehydrogenase activity
I6H90_RS05045	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6H90_RS05050	COG0745	RESPONSE REGULATOR receiver
I6H90_RS05070	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6H90_RS05075	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
I6H90_RS05080	COG1511	domain protein
I6H90_RS05085	COG1959	2 iron, 2 sulfur cluster binding
I6H90_RS05090	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I6H90_RS05095	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6H90_RS05100	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6H90_RS05110	COG1132	(ABC) transporter
I6H90_RS05115	COG1132	(ABC) transporter
I6H90_RS05120	COG1126	abc transporter atp-binding protein
I6H90_RS05125	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6H90_RS05130	COG0765	amino acid transport
I6H90_RS05135	COG0765	amino acid transport
I6H90_RS05140	COG4166	transmembrane transport
I6H90_RS05145	COG0601	transmembrane transport
I6H90_RS05150	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6H90_RS05155	COG0444	Belongs to the ABC transporter superfamily
I6H90_RS05160	COG4608	Belongs to the ABC transporter superfamily
I6H90_RS05165	COG3590	peptidase
I6H90_RS05195	COG0126	phosphoglycerate kinase activity
I6H90_RS05200	COG2814	Major facilitator Superfamily
I6H90_RS05205	COG1064	alcohol dehydrogenase
I6H90_RS05225	COG0488	(ABC) transporter
I6H90_RS05315	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6H90_RS05325	COG0697	spore germination
I6H90_RS05335	COG1309	transcriptional regulator
I6H90_RS05340	COG1511	domain protein
I6H90_RS05340	COG1511	domain protein
I6H90_RS05385	COG3973	AAA domain
I6H90_RS05395	COG2814	Major facilitator Superfamily
I6H90_RS05405	COG1278	Cold shock
I6H90_RS05410	COG0588	phosphoglycerate mutase activity
I6H90_RS05420	COG0356	it plays a direct role in the translocation of protons across the membrane
I6H90_RS05425	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I6H90_RS05430	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
I6H90_RS05435	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I6H90_RS05440	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
I6H90_RS05445	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
I6H90_RS05450	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I6H90_RS05455	COG0355	proton-transporting ATP synthase activity, rotational mechanism
I6H90_RS05460	COG1705	Flagellar rod assembly protein muramidase FlgJ
I6H90_RS05460	COG1388	LysM domain
I6H90_RS05465	COG1902	pentaerythritol trinitrate reductase activity
I6H90_RS05475	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I6H90_RS05480	COG2814	Major facilitator Superfamily
I6H90_RS05490	COG1194	a g-specific adenine glycosylase
I6H90_RS05495	COG0628	permease
I6H90_RS05510	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6H90_RS05520	COG0531	amino acid
I6H90_RS05525	COG4166	transmembrane transport
I6H90_RS05530	COG1228	amidohydrolase
I6H90_RS05535	COG1316	TRANSCRIPTIONal
I6H90_RS05545	COG0833	amino acid
I6H90_RS05555	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6H90_RS05560	COG5506	Protein of unknown function (DUF1694)
I6H90_RS05565	COG2211	Major facilitator Superfamily
I6H90_RS05575	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I6H90_RS05580	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
I6H90_RS05585	COG0531	amino acid
I6H90_RS05590	COG0194	GDP metabolic process
I6H90_RS05595	COG0436	Aminotransferase
I6H90_RS05660	COG0085	RNA polymerase activity
I6H90_RS05665	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I6H90_RS05670	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
I6H90_RS05675	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6H90_RS05700	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6H90_RS05705	COG1696	Membrane protein involved in D-alanine export
I6H90_RS05710	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6H90_RS05715	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
I6H90_RS05720	COG0736	holo-[acyl-carrier-protein] synthase activity
I6H90_RS05725	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6H90_RS05730	COG2337	Toxic component of a toxin-antitoxin (TA) module
I6H90_RS05735	COG0745	RESPONSE REGULATOR receiver
I6H90_RS05740	COG5002	protein histidine kinase activity
I6H90_RS05745	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6H90_RS05750	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6H90_RS05755	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
I6H90_RS05760	COG0626	cystathionine gamma-synthase activity
I6H90_RS05765	COG0626	cystathionine gamma-synthase activity
I6H90_RS05770	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I6H90_RS05775	COG1854	S-ribosylhomocysteine lyase activity
I6H90_RS05780	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I6H90_RS05785	COG2873	o-acetylhomoserine
I6H90_RS05795	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I6H90_RS05800	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I6H90_RS05805	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I6H90_RS05810	COG0628	permease
I6H90_RS05820	COG0531	amino acid
I6H90_RS05830	COG3442	glutamine amidotransferase
I6H90_RS05835	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6H90_RS05840	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
I6H90_RS05845	COG0791	NLP P60 protein
I6H90_RS05845	COG3883	PFAM NLP P60 protein
I6H90_RS05850	COG1435	thymidine kinase activity
I6H90_RS05855	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I6H90_RS05860	COG2890	protein-(glutamine-N5) methyltransferase activity
I6H90_RS05865	COG0009	L-threonylcarbamoyladenylate synthase
I6H90_RS05870	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
I6H90_RS05880	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6H90_RS05885	COG1214	PFAM Peptidase M22, glycoprotease
I6H90_RS05900	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I6H90_RS05905	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
I6H90_RS05915	COG0561	phosphatase activity
I6H90_RS05925	COG0778	Nitroreductase
I6H90_RS05930	COG1482	cell wall glycoprotein biosynthetic process
I6H90_RS05940	COG3715	PTS system
I6H90_RS05945	COG3716	PTS system mannose fructose sorbose family IID component
I6H90_RS05960	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I6H90_RS05965	COG0459	protein refolding
I6H90_RS05985	COG2323	membrane
I6H90_RS06015	COG5263	repeat protein
I6H90_RS06015	COG0366	Alpha amylase catalytic
I6H90_RS06040	COG0366	Alpha amylase catalytic
I6H90_RS06040	COG5263	repeat protein
I6H90_RS06045	COG1959	2 iron, 2 sulfur cluster binding
I6H90_RS06070	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
I6H90_RS06075	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I6H90_RS06080	COG1534	Rna-binding protein
I6H90_RS06085	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I6H90_RS06090	COG1713	HD superfamily hydrolase involved in NAD metabolism
I6H90_RS06095	COG0799	negative regulation of ribosome biogenesis
I6H90_RS06100	COG2226	methyltransferase
I6H90_RS06105	COG1323	Belongs to the UPF0348 family
I6H90_RS06115	COG0745	RESPONSE REGULATOR receiver
I6H90_RS06120	COG5002	protein histidine kinase activity
I6H90_RS06125	COG1254	Belongs to the acylphosphatase family
I6H90_RS06130	COG0706	membrane insertase activity
I6H90_RS06135	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6H90_RS06145	COG0557	exoribonuclease II activity
I6H90_RS06150	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
I6H90_RS06155	COG1418	mRNA catabolic process
I6H90_RS06170	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I6H90_RS06190	COG1193	negative regulation of DNA recombination
I6H90_RS06210	COG0194	GDP metabolic process
I6H90_RS06215	COG1758	RNA polymerase activity
I6H90_RS06225	COG1098	S1 RNA binding domain
I6H90_RS06255	COG1393	Belongs to the ArsC family
I6H90_RS06260	COG4862	establishment of competence for transformation
I6H90_RS06275	COG0584	glycerophosphoryl diester phosphodiesterase
I6H90_RS06280	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I6H90_RS06290	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I6H90_RS06305	COG1892	Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four- carbon dicarboxylic acid source for the tricarboxylic acid cycle
I6H90_RS06315	COG3152	Membrane
I6H90_RS06370	COG3561	AntA/AntB antirepressor
I6H90_RS06400	COG3723	Recombinational DNA repair protein, rece pathway
I6H90_RS06530	COG0740	serine-type endopeptidase activity
I6H90_RS06650	COG5503	Protein of unknown function (DUF1447)
I6H90_RS06655	COG1611	Belongs to the LOG family
I6H90_RS06665	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I6H90_RS06675	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6H90_RS06680	COG0084	hydrolase, TatD family'
I6H90_RS06685	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
I6H90_RS06690	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I6H90_RS06695	COG4466	Protein conserved in bacteria
I6H90_RS06705	COG1121	(ABC) transporter
I6H90_RS06710	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6H90_RS06715	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6H90_RS06720	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I6H90_RS06735	COG1570	exodeoxyribonuclease VII activity
I6H90_RS06740	COG1722	exodeoxyribonuclease VII activity
I6H90_RS06745	COG0142	geranyltranstransferase activity
I6H90_RS06750	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
I6H90_RS06755	COG1438	arginine binding
I6H90_RS06760	COG0497	DNA recombination
I6H90_RS06765	COG2252	PERMEase
I6H90_RS06770	COG0534	Mate efflux family protein
I6H90_RS06775	COG0588	phosphoglycerate mutase activity
I6H90_RS06780	COG1363	Peptidase, m42
I6H90_RS06785	COG0772	Belongs to the SEDS family
I6H90_RS06790	COG4471	UPF0298 protein
I6H90_RS06795	COG0742	ribosomal rna small subunit methyltransferase
I6H90_RS06800	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
I6H90_RS06805	COG3480	Lon protease (S16) C-terminal proteolytic domain
I6H90_RS06810	COG1555	photosystem II stabilization
I6H90_RS06810	COG1596	polysaccharide export
I6H90_RS06815	COG2333	competence protein COMEC
I6H90_RS06815	COG0658	competence protein
I6H90_RS06820	COG1466	dna polymerase III delta subunit
I6H90_RS06825	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6H90_RS06830	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I6H90_RS06835	COG0513	Belongs to the DEAD box helicase family
I6H90_RS06840	COG0268	Binds directly to 16S ribosomal RNA
I6H90_RS06845	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
I6H90_RS06850	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6H90_RS06855	COG0154	amidase activity
I6H90_RS06865	COG1597	lipid kinase activity
I6H90_RS06870	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6H90_RS06875	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
I6H90_RS06880	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I6H90_RS06890	COG3237	CsbD-like
I6H90_RS06895	COG4807	Protein conserved in bacteria
I6H90_RS06900	COG0105	UTP biosynthetic process
I6H90_RS06905	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I6H90_RS06925	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6H90_RS06930	COG0571	ribonuclease III activity
I6H90_RS06935	COG1196	nuclear chromosome segregation
I6H90_RS06940	COG0552	protein localization to endoplasmic reticulum
I6H90_RS06950	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I6H90_RS06960	COG0561	phosphatase activity
I6H90_RS06965	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
I6H90_RS06975	COG2199	diguanylate cyclase activity
I6H90_RS06980	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I6H90_RS06985	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I6H90_RS06990	COG0131	Imidazoleglycerol-phosphate dehydratase
I6H90_RS07000	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
I6H90_RS07005	COG0107	imidazoleglycerol-phosphate synthase activity
I6H90_RS07010	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
I6H90_RS07015	COG0140	phosphoribosyl-ATP diphosphatase activity
I6H90_RS07020	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6H90_RS07035	COG4172	Belongs to the ABC transporter superfamily
I6H90_RS07055	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I6H90_RS07060	COG1328	CTP reductase activity
I6H90_RS07065	COG0602	queuosine metabolic process
I6H90_RS07100	COG0802	atpase or kinase
I6H90_RS07105	COG0456	acetyltransferase
I6H90_RS07110	COG2176	DNA-directed DNA polymerase activity
I6H90_RS07115	COG0708	Exodeoxyribonuclease III
I6H90_RS07120	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I6H90_RS07140	COG0544	peptidyl-prolyl cis-trans isomerase activity
I6H90_RS07145	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
I6H90_RS07150	COG0218	Necessary for normal cell division and for the maintenance of normal septation
I6H90_RS07155	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6H90_RS07160	COG3201	nicotinamide mononucleotide transporter
I6H90_RS07175	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6H90_RS07180	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I6H90_RS07185	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6H90_RS07185	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6H90_RS07190	COG0631	protein serine/threonine phosphatase activity
I6H90_RS07195	COG2815	serine threonine protein kinase
I6H90_RS07195	COG0515	serine threonine protein kinase
I6H90_RS07200	COG1162	GTPase activity
I6H90_RS07205	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6H90_RS07210	COG1564	THIamine pyrophosphokinase
I6H90_RS07215	COG3118	belongs to the thioredoxin family
I6H90_RS07220	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I6H90_RS07230	COG1461	Dihydroxyacetone kinase
I6H90_RS07245	COG2001	Belongs to the MraZ family
I6H90_RS07250	COG0275	rRNA processing
I6H90_RS07260	COG0768	penicillin binding
I6H90_RS07265	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6H90_RS07270	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I6H90_RS07275	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I6H90_RS07280	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I6H90_RS07295	COG1799	cell septum assembly
I6H90_RS07300	COG0762	integral membrane protein
I6H90_RS07325	COG0228	four-way junction DNA binding
I6H90_RS07340	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
I6H90_RS07345	COG1074	ATP-dependent DNA helicase activity
I6H90_RS07355	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I6H90_RS07360	COG0336	Belongs to the RNA methyltransferase TrmD family
I6H90_RS07365	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I6H90_RS07370	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6H90_RS07375	COG1234	tRNA 3'-trailer cleavage
I6H90_RS07380	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
I6H90_RS07380	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I6H90_RS07385	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6H90_RS07415	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I6H90_RS07420	COG0280	phosphate acetyltransferase
I6H90_RS07430	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
I6H90_RS07435	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6H90_RS07445	COG0217	transcriptional regulatory protein
I6H90_RS07450	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I6H90_RS07455	COG0137	argininosuccinate synthase activity
I6H90_RS07460	COG0165	Argininosuccinate lyase
I6H90_RS07470	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
I6H90_RS07515	COG3142	Participates in the control of copper homeostasis
I6H90_RS07520	COG0333	Belongs to the bacterial ribosomal protein bL32 family
I6H90_RS07540	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I6H90_RS07545	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
I6H90_RS07550	COG1114	Component of the transport system for branched-chain amino acids
I6H90_RS07555	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I6H90_RS07560	COG1316	TRANSCRIPTIONal
I6H90_RS07565	COG0024	Methionine aminopeptidase
I6H90_RS07580	COG0489	protein tyrosine kinase activity
I6H90_RS07585	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6H90_RS07590	COG0438	transferase activity, transferring glycosyl groups
I6H90_RS07595	COG1215	transferase activity, transferring glycosyl groups
I6H90_RS07595	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I6H90_RS07605	COG1442	glycosyl transferase family 8
I6H90_RS07610	COG1216	Glycosyl transferase, family 2
I6H90_RS07635	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
I6H90_RS07645	COG1088	dTDP-glucose 4,6-dehydratase activity
I6H90_RS07650	COG1091	dTDP-4-dehydrorhamnose reductase activity
I6H90_RS07720	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6H90_RS07740	COG0562	UDP-galactopyranose mutase
I6H90_RS07745	COG0463	Glycosyl transferase, family 2
I6H90_RS07775	COG1216	Glycosyl transferase, family 2
I6H90_RS07785	COG0716	FMN binding
I6H90_RS07790	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6H90_RS07795	COG2116	formate transmembrane transporter activity
I6H90_RS07800	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I6H90_RS07810	COG1304	FMN binding
I6H90_RS07830	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6H90_RS07830	COG1199	ATP-dependent helicase activity
I6H90_RS07840	COG0436	Aminotransferase
I6H90_RS07845	COG0017	Asparaginyl-tRNA synthetase
I6H90_RS07860	COG0116	Belongs to the methyltransferase superfamily
I6H90_RS07865	COG0436	Aminotransferase
I6H90_RS07875	COG0328	RNA-DNA hybrid ribonuclease activity
I6H90_RS07885	COG0564	pseudouridine synthase activity
I6H90_RS07890	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
I6H90_RS07895	COG0505	Belongs to the CarA family
I6H90_RS07915	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6H90_RS07920	COG1490	D-aminoacyl-tRNA deacylase activity
I6H90_RS07930	COG0187	DNA topoisomerase II activity
I6H90_RS07940	COG1227	inorganic diphosphatase activity
I6H90_RS07945	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6H90_RS07950	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I6H90_RS07955	COG0779	Required for maturation of 30S ribosomal subunits
I6H90_RS07960	COG0195	Participates in both transcription termination and antitermination
I6H90_RS07965	COG2740	Nucleic-acid-binding protein implicated in transcription termination
I6H90_RS07975	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
I6H90_RS07980	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I6H90_RS07985	COG0436	Aminotransferase
I6H90_RS07995	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I6H90_RS08000	COG0196	riboflavin kinase activity
I6H90_RS08005	COG1420	regulation of RNA biosynthetic process
I6H90_RS08010	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I6H90_RS08015	COG0443	Heat shock 70 kDa protein
I6H90_RS08020	COG0484	heat shock protein binding
I6H90_RS08025	COG0242	peptide deformylase activity
I6H90_RS08030	COG4476	Belongs to the UPF0223 family
I6H90_RS08035	COG0483	inositol monophosphate 1-phosphatase activity
I6H90_RS08040	COG1217	gtp-binding protein TYPA
I6H90_RS08070	COG2962	Rard protein
I6H90_RS08075	COG1247	-acetyltransferase
I6H90_RS08110	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I6H90_RS08115	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I6H90_RS08120	COG0006	proline dipeptidase activity
I6H90_RS08130	COG0737	Belongs to the 5'-nucleotidase family
I6H90_RS08135	COG4470	Protein conserved in bacteria
I6H90_RS08145	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6H90_RS08150	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6H90_RS08160	COG3250	beta-galactosidase activity
I6H90_RS08165	COG0667	Aldo Keto reductase
I6H90_RS08175	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I6H90_RS08180	COG2207	Transcriptional regulator
I6H90_RS08185	COG2017	converts alpha-aldose to the beta-anomer
I6H90_RS08190	COG0124	histidyl-tRNA synthetase
I6H90_RS08195	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I6H90_RS08200	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I6H90_RS08205	COG1113	amino acid transport
I6H90_RS08210	COG2508	Transcriptional regulator
I6H90_RS08215	COG0477	Major facilitator Superfamily
I6H90_RS08220	COG0828	Belongs to the bacterial ribosomal protein bS21 family
I6H90_RS08225	COG1610	YqeY-like protein
I6H90_RS08230	COG2996	Protein conserved in bacteria
I6H90_RS08235	COG4974	Belongs to the 'phage' integrase family
I6H90_RS08245	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
I6H90_RS08250	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I6H90_RS08255	COG1187	pseudouridine synthase activity
I6H90_RS08260	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
I6H90_RS08270	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I6H90_RS08275	COG0539	negative regulation of cytoplasmic translation
I6H90_RS08280	COG1160	GTP binding
I6H90_RS08285	COG0776	regulation of translation
I6H90_RS08290	COG1045	serine acetyltransferase
I6H90_RS08295	COG0626	cystathionine gamma-synthase activity
I6H90_RS08300	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6H90_RS08310	COG1970	mechanosensitive ion channel activity
I6H90_RS08320	COG2183	response to ionizing radiation
I6H90_RS08330	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6H90_RS08335	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6H90_RS08340	COG0167	dihydroorotate dehydrogenase activity
I6H90_RS08345	COG0488	(ABC) transporter
I6H90_RS08350	COG0758	DNA mediated transformation
I6H90_RS08385	COG3716	PTS system mannose fructose sorbose family IID component
I6H90_RS08520	COG0358	DNA primase activity
I6H90_RS08525	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6H90_RS08535	COG1028	Short-chain dehydrogenase reductase Sdr
I6H90_RS08545	COG0626	cystathionine gamma-synthase activity
I6H90_RS08550	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6H90_RS08555	COG0765	amino acid transport
I6H90_RS08560	COG1126	abc transporter atp-binding protein
I6H90_RS08565	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6H90_RS08570	COG0436	Aminotransferase
I6H90_RS08580	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6H90_RS08590	COG0537	adenosine 5'-monophosphoramidase activity
I6H90_RS08595	COG1131	(ABC) transporter
I6H90_RS08605	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I6H90_RS08645	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I6H90_RS08655	COG0018	arginyl-trna synthetase
I6H90_RS08660	COG1438	arginine binding
I6H90_RS08665	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6H90_RS08670	COG3679	Belongs to the UPF0342 family
I6H90_RS08680	COG0540	Belongs to the ATCase OTCase family
I6H90_RS08685	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I6H90_RS08690	COG0505	Belongs to the CarA family
I6H90_RS08695	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I6H90_RS08700	COG0284	orotidine-5'-phosphate decarboxylase activity
I6H90_RS08705	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
I6H90_RS08710	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6H90_RS08715	COG3763	UPF0154 protein
I6H90_RS08720	COG0204	Acyl-transferase
I6H90_RS08725	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
I6H90_RS08730	COG2827	Endonuclease containing a URI domain
I6H90_RS08735	COG0052	Belongs to the universal ribosomal protein uS2 family
I6H90_RS08740	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I6H90_RS08745	COG0528	UMP kinase activity
I6H90_RS08750	COG0233	cytoplasmic translational termination
I6H90_RS08760	COG0752	glycyl-tRNA synthetase alpha subunit
I6H90_RS08765	COG0751	glycine-tRNA ligase activity
I6H90_RS08770	COG0673	inositol 2-dehydrogenase activity
I6H90_RS08790	COG2264	protein methyltransferase activity
I6H90_RS08795	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6H90_RS08805	COG0488	(ABC) transporter
I6H90_RS08810	COG3425	synthase
I6H90_RS08830	COG2848	UPF0210 protein
I6H90_RS08855	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6H90_RS08860	COG0134	indole-3-glycerol-phosphate synthase activity
I6H90_RS08870	COG0159	tryptophan synthase activity
I6H90_RS08875	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I6H90_RS08880	COG0512	Glutamine amidotransferase of anthranilate synthase
I6H90_RS08885	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6H90_RS08895	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
I6H90_RS08900	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I6H90_RS08905	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
I6H90_RS08910	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I6H90_RS08915	COG0287	Prephenate dehydrogenase
I6H90_RS08920	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I6H90_RS08930	COG0710	3-dehydroquinate dehydratase activity
I6H90_RS08935	COG0352	thiamine-phosphate diphosphorylase activity
I6H90_RS08940	COG2104	thiamine diphosphate biosynthetic process
I6H90_RS08940	COG2022	thiamine diphosphate biosynthetic process
I6H90_RS08945	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6H90_RS08950	COG2022	thiamine diphosphate biosynthetic process
I6H90_RS08960	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6H90_RS08965	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6H90_RS08970	COG1116	anion transmembrane transporter activity
I6H90_RS08980	COG0318	PFAM AMP-dependent synthetase and ligase
I6H90_RS08990	COG1028	Short-chain dehydrogenase reductase Sdr
I6H90_RS09000	COG2814	Major facilitator Superfamily
I6H90_RS09015	COG2409	Drug exporters of the RND superfamily
I6H90_RS09020	COG4585	Histidine kinase
I6H90_RS09025	COG2197	response regulator
I6H90_RS09030	COG1917	Cupin 2, conserved barrel domain protein
I6H90_RS09030	COG2169	Transcriptional regulator
I6H90_RS09060	COG0131	Imidazoleglycerol-phosphate dehydratase
I6H90_RS09060	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I6H90_RS09075	COG2826	transposase and inactivated derivatives, IS30 family
I6H90_RS09150	COG1192	Involved in chromosome partitioning
I6H90_RS09175	COG0542	response to heat
I6H90_RS09245	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6H90_RS09265	COG1012	belongs to the aldehyde dehydrogenase family
I6H90_RS09270	COG0789	Transcriptional regulator
I6H90_RS09275	COG0656	L-ascorbic acid biosynthetic process
I6H90_RS09280	COG0656	L-ascorbic acid biosynthetic process
I6H90_RS09285	COG4221	oxidoreductase activity
I6H90_RS09300	COG0667	Aldo Keto reductase
I6H90_RS09325	COG0716	FMN binding
I6H90_RS09340	COG0542	response to heat
I6H90_RS09370	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I6H90_RS09375	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6H90_RS09380	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
I6H90_RS09385	COG3867	Arabinogalactan endo-beta-1,4-galactanase
I6H90_RS09395	COG1874	Beta-galactosidase
I6H90_RS09400	COG1609	Transcriptional regulator
I6H90_RS09460	COG2826	transposase and inactivated derivatives, IS30 family
I6H90_RS09480	COG0577	efflux transmembrane transporter activity
I6H90_RS09485	COG1562	ergosterol biosynthetic process
I6H90_RS09490	COG1233	COG1233 Phytoene dehydrogenase and related
I6H90_RS09520	COG1674	ftsk spoiiie
I6H90_RS09530	COG0433	COG0433 Predicted ATPase
I6H90_RS09625	COG1125	glycine betaine transport
I6H90_RS09660	COG3158	transport of potassium into the cell
I6H90_RS09670	COG2801	Transposase and inactivated derivatives
I6H90_RS09700	COG0583	DNA-binding transcription factor activity
I6H90_RS09715	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6H90_RS09715	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6H90_RS09725	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6H90_RS09730	COG2017	converts alpha-aldose to the beta-anomer
I6H90_RS09755	COG2801	Transposase and inactivated derivatives
I6H90_RS09775	COG1984	allophanate hydrolase subunit 2
I6H90_RS09780	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I6H90_RS09785	COG1914	H( )-stimulated, divalent metal cation uptake system
I6H90_RS09790	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
I6H90_RS09805	COG0511	ligase activity, forming carbon-carbon bonds
I6H90_RS09825	COG0702	epimerase
I6H90_RS09830	COG0071	Belongs to the small heat shock protein (HSP20) family
I6H90_RS09835	COG0028	Belongs to the TPP enzyme family
I6H90_RS09850	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6H90_RS09855	COG2364	Membrane
I6H90_RS09865	COG0300	oxidoreductase activity
I6H90_RS09870	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6H90_RS09880	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6H90_RS09890	COG0656	L-ascorbic acid biosynthetic process
I6H90_RS09900	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I6H90_RS09905	COG2814	Major facilitator Superfamily
I6H90_RS09910	COG1846	Transcriptional regulator
I6H90_RS09915	COG1316	TRANSCRIPTIONal
I6H90_RS09935	COG5002	protein histidine kinase activity
I6H90_RS09940	COG0745	RESPONSE REGULATOR receiver
I6H90_RS09950	COG3527	Alpha-acetolactate decarboxylase
I6H90_RS09960	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6H90_RS09965	COG1121	(ABC) transporter
I6H90_RS09970	COG1442	glycosyl transferase family 8
I6H90_RS09990	COG1846	Transcriptional regulator
I6H90_RS09995	COG1733	regulation of RNA biosynthetic process
I6H90_RS10010	COG2723	6-phospho-beta-galactosidase activity
I6H90_RS10030	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
I6H90_RS10040	COG1028	Short-chain dehydrogenase reductase Sdr
I6H90_RS10060	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6H90_RS10070	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6H90_RS10075	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6H90_RS10075	COG3711	transcriptional antiterminator
I6H90_RS10085	COG2723	6-phospho-beta-galactosidase activity
I6H90_RS10095	COG1619	proteins homologs of microcin C7 resistance protein MccF
I6H90_RS10100	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
I6H90_RS10105	COG2610	gluconate transmembrane transporter activity
I6H90_RS10110	COG1028	Short-chain dehydrogenase reductase Sdr
I6H90_RS10115	COG0436	Aminotransferase
I6H90_RS10125	COG0693	protein deglycase activity
I6H90_RS10140	COG4720	Psort location CytoplasmicMembrane, score
I6H90_RS10145	COG1573	uracil-dna glycosylase
I6H90_RS10150	COG1129	ABC transporter
I6H90_RS10160	COG1063	alcohol dehydrogenase
I6H90_RS10165	COG0477	Major facilitator Superfamily
I6H90_RS10175	COG0300	oxidoreductase activity
I6H90_RS10195	COG2244	polysaccharide biosynthetic process
I6H90_RS10200	COG1956	GAF domain-containing protein
I6H90_RS10210	COG2723	6-phospho-beta-galactosidase activity
I6H90_RS10220	COG3711	transcriptional antiterminator
I6H90_RS10225	COG1192	Involved in chromosome partitioning
I6H90_RS10280	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6H90_RS10290	COG4619	ABC transporter
I6H90_RS10295	COG0390	transport system, permease component
I6H90_RS10325	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6H90_RS10330	COG0783	Belongs to the Dps family
I6H90_RS10355	COG1937	Protein conserved in bacteria
I6H90_RS10360	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6H90_RS10365	COG3118	belongs to the thioredoxin family
I6H90_RS10430	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I6H90_RS10450	COG2801	Transposase and inactivated derivatives
I6H90_RS10455	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6H90_RS10460	COG1573	uracil-dna glycosylase