locus-tag	class	description
LMES_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
LMES_RS00010	COG0592	DNA-directed DNA polymerase activity
LMES_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
LMES_RS00025	COG0187	DNA topoisomerase II activity
LMES_RS00035	COG0386	Belongs to the glutathione peroxidase family
LMES_RS00065	COG1073	alpha beta
LMES_RS00080	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
LMES_RS00085	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LMES_RS00090	COG0436	Aminotransferase
LMES_RS00185	COG2814	Major facilitator Superfamily
LMES_RS00190	COG0647	UMP catabolic process
LMES_RS00210	COG1368	sulfuric ester hydrolase activity
LMES_RS00215	COG0438	transferase activity, transferring glycosyl groups
LMES_RS00225	COG0564	pseudouridine synthase activity
LMES_RS00230	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
LMES_RS00235	COG2217	Heavy metal translocating P-type atpase
LMES_RS00245	COG1725	Transcriptional regulator
LMES_RS00250	COG1131	(ABC) transporter
LMES_RS00260	COG1131	(ABC) transporter
LMES_RS00280	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LMES_RS00285	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
LMES_RS00290	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
LMES_RS00295	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
LMES_RS00300	COG1881	PFAM PEBP family protein
LMES_RS00315	COG0569	domain protein
LMES_RS00320	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
LMES_RS00325	COG2271	Major facilitator Superfamily
LMES_RS00355	COG3845	ABC transporter
LMES_RS00360	COG4603	Belongs to the binding-protein-dependent transport system permease family
LMES_RS00365	COG1079	Belongs to the binding-protein-dependent transport system permease family
LMES_RS00380	COG4120	Belongs to the binding-protein-dependent transport system permease family
LMES_RS00390	COG1396	sequence-specific DNA binding
LMES_RS00435	COG0351	phosphomethylpyrimidine kinase
LMES_RS00450	COG1131	(ABC) transporter
LMES_RS00460	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
LMES_RS00465	COG0463	Glycosyl transferase, family 2
LMES_RS00475	COG0446	pyridine nucleotide-disulphide oxidoreductase
LMES_RS00495	COG0456	acetyltransferase
LMES_RS00500	COG0765	amino acid transport
LMES_RS00505	COG1126	abc transporter atp-binding protein
LMES_RS00510	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LMES_RS00515	COG1473	amidohydrolase
LMES_RS00520	COG3118	belongs to the thioredoxin family
LMES_RS00525	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
LMES_RS00530	COG0531	amino acid
LMES_RS00540	COG1464	Belongs to the NlpA lipoprotein family
LMES_RS00550	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
LMES_RS00555	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
LMES_RS00560	COG1307	EDD domain protein, DegV family
LMES_RS00565	COG1272	protein, Hemolysin III
LMES_RS00595	COG1968	undecaprenyl-diphosphatase activity
LMES_RS00610	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LMES_RS00615	COG0765	amino acid transport
LMES_RS00620	COG0765	amino acid transport
LMES_RS00625	COG1126	abc transporter atp-binding protein
LMES_RS00630	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
LMES_RS00640	COG4720	Psort location CytoplasmicMembrane, score
LMES_RS00645	COG0351	phosphomethylpyrimidine kinase
LMES_RS00660	COG1454	alcohol dehydrogenase
LMES_RS00660	COG1012	belongs to the aldehyde dehydrogenase family
LMES_RS00665	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LMES_RS00700	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
LMES_RS00710	COG0756	dUTP diphosphatase activity
LMES_RS00715	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
LMES_RS00725	COG1309	transcriptional regulator
LMES_RS00730	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LMES_RS00735	COG0215	cysteine-tRNA ligase activity
LMES_RS00835	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
LMES_RS00840	COG0653	protein targeting
LMES_RS00845	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
LMES_RS00850	COG0542	response to heat
LMES_RS00855	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
LMES_RS00860	COG0049	tRNA binding
LMES_RS00865	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
LMES_RS00870	COG2807	transmembrane transport
LMES_RS00875	COG3842	ATPase activity
LMES_RS00880	COG1177	transmembrane transport
LMES_RS00885	COG1177	transmembrane transport
LMES_RS00895	COG0051	transcription antitermination factor activity, RNA binding
LMES_RS00900	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
LMES_RS00905	COG0088	Forms part of the polypeptide exit tunnel
LMES_RS00910	COG0089	rRNA binding
LMES_RS00915	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
LMES_RS00920	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
LMES_RS00925	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
LMES_RS00930	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
LMES_RS00935	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
LMES_RS00940	COG0255	Belongs to the universal ribosomal protein uL29 family
LMES_RS00945	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
LMES_RS00950	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
LMES_RS00955	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
LMES_RS00960	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
LMES_RS00965	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
LMES_RS00970	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
LMES_RS00975	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
LMES_RS00980	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
LMES_RS00985	COG1841	ribosomal large subunit assembly
LMES_RS00990	COG0200	Binds to the 23S rRNA
LMES_RS01000	COG0563	adenylate kinase activity
LMES_RS01005	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
LMES_RS01010	COG0257	Belongs to the bacterial ribosomal protein bL36 family
LMES_RS01015	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
LMES_RS01020	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
LMES_RS01025	COG0202	RNA polymerase activity
LMES_RS01030	COG0203	ribosomal protein L17
LMES_RS01035	COG0142	geranyltranstransferase activity
LMES_RS01045	COG1122	ATPase activity
LMES_RS01050	COG1122	ATPase activity
LMES_RS01055	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
LMES_RS01060	COG0101	tRNA pseudouridine synthase activity
LMES_RS01070	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
LMES_RS01075	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
LMES_RS01105	COG0149	triose-phosphate isomerase activity
LMES_RS01110	COG0148	phosphopyruvate hydratase activity
LMES_RS01115	COG0519	Catalyzes the synthesis of GMP from XMP
LMES_RS01125	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
LMES_RS01135	COG1739	Uncharacterized protein family UPF0029
LMES_RS01140	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
LMES_RS01145	COG1040	competence protein
LMES_RS01160	COG0588	phosphoglycerate mutase activity
LMES_RS01165	COG1253	flavin adenine dinucleotide binding
LMES_RS01170	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
LMES_RS01175	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LMES_RS01180	COG1780	Probably involved in ribonucleotide reductase function
LMES_RS01195	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
LMES_RS01205	COG1077	Cell shape determining protein MreB Mrl
LMES_RS01215	COG0772	Belongs to the SEDS family
LMES_RS01225	COG1181	Belongs to the D-alanine--D-alanine ligase family
LMES_RS01245	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
LMES_RS01250	COG0081	regulation of translation
LMES_RS01255	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
LMES_RS01260	COG0222	ribosome binding
LMES_RS01265	COG2813	Specifically methylates the guanine in position
LMES_RS01270	COG0590	tRNA wobble adenosine to inosine editing
LMES_RS01280	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
LMES_RS01285	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
LMES_RS01295	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
LMES_RS01300	COG3870	Protein conserved in bacteria
LMES_RS01305	COG0470	DNA polymerase III
LMES_RS01320	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LMES_RS01335	COG1609	Transcriptional regulator
LMES_RS01345	COG1621	beta-fructofuranosidase activity
LMES_RS01350	COG1940	carbohydrate kinase activity
LMES_RS01365	COG1428	Deoxynucleoside kinase
LMES_RS01370	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
LMES_RS01375	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
LMES_RS01385	COG0492	ferredoxin-NADP+ reductase activity
LMES_RS01395	COG1418	mRNA catabolic process
LMES_RS01400	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LMES_RS01400	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LMES_RS01405	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
LMES_RS01405	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
LMES_RS01415	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
LMES_RS01435	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LMES_RS01445	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LMES_RS01450	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LMES_RS01460	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
LMES_RS01465	COG1028	Short-chain dehydrogenase reductase Sdr
LMES_RS01470	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LMES_RS01475	COG0511	ligase activity, forming carbon-carbon bonds
LMES_RS01485	COG0439	Biotin carboxylase
LMES_RS01490	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
LMES_RS01505	COG0525	valine-tRNA ligase activity
LMES_RS01510	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LMES_RS01525	COG1388	LysM domain
LMES_RS01525	COG3103	Sh3 type 3 domain protein
LMES_RS01525	COG0791	NLP P60 protein
LMES_RS01535	COG0768	penicillin binding
LMES_RS01540	COG0640	Transcriptional regulator
LMES_RS01550	COG0577	efflux transmembrane transporter activity
LMES_RS01550	COG1136	(ABC) transporter
LMES_RS01555	COG1316	TRANSCRIPTIONal
LMES_RS01580	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
LMES_RS01590	COG1914	H( )-stimulated, divalent metal cation uptake system
LMES_RS01600	COG0640	Transcriptional regulator
LMES_RS01615	COG1957	nucleoside hydrolase
LMES_RS01620	COG0357	Ribosomal RNA small subunit methyltransferase G
LMES_RS01625	COG1192	Involved in chromosome partitioning
LMES_RS01630	COG1475	DNA binding
LMES_RS01635	COG4481	Protein conserved in bacteria
LMES_RS01640	COG0012	GTP binding
LMES_RS01650	COG0745	RESPONSE REGULATOR receiver
LMES_RS01655	COG2205	protein histidine kinase activity
LMES_RS01665	COG0363	glucosamine-6-phosphate deaminase activity
LMES_RS01670	COG0166	Belongs to the GPI family
LMES_RS01680	COG3448	diguanylate cyclase activity
LMES_RS01680	COG4175	Glycine betaine
LMES_RS01700	COG4152	abc transporter atp-binding protein
LMES_RS01735	COG0765	amino acid transport
LMES_RS01740	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LMES_RS01745	COG0765	amino acid transport
LMES_RS01750	COG1126	abc transporter atp-binding protein
LMES_RS01755	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LMES_RS01760	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LMES_RS01765	COG1126	abc transporter atp-binding protein
LMES_RS01770	COG2814	Major facilitator Superfamily
LMES_RS01775	COG0343	queuine tRNA-ribosyltransferase activity
LMES_RS01780	COG1862	Preprotein translocase
LMES_RS01790	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
LMES_RS01790	COG0392	lysyltransferase activity
LMES_RS01805	COG0406	alpha-ribazole phosphatase activity
LMES_RS01820	COG1132	(ABC) transporter
LMES_RS01825	COG1132	(ABC) transporter
LMES_RS01830	COG0438	transferase activity, transferring glycosyl groups
LMES_RS01850	COG1368	sulfuric ester hydrolase activity
LMES_RS01855	COG0556	nucleotide-excision repair
LMES_RS01860	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LMES_RS01865	COG0391	Required for morphogenesis under gluconeogenic growth conditions
LMES_RS01870	COG1481	regulation of sporulation
LMES_RS01875	COG0740	serine-type endopeptidase activity
LMES_RS01885	COG0193	aminoacyl-tRNA hydrolase activity
LMES_RS01890	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
LMES_RS01895	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
LMES_RS01905	COG0037	tRNA processing
LMES_RS01915	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LMES_RS01920	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
LMES_RS01925	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
LMES_RS01950	COG0217	transcriptional regulatory protein
LMES_RS01955	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
LMES_RS01965	COG2252	PERMEase
LMES_RS01970	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
LMES_RS01995	COG0477	Major facilitator Superfamily
LMES_RS02015	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
LMES_RS02025	COG2188	Transcriptional regulator
LMES_RS02035	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
LMES_RS02045	COG1464	Belongs to the NlpA lipoprotein family
LMES_RS02080	COG1744	ABC transporter substrate-binding protein PnrA-like
LMES_RS02085	COG0765	amino acid transport
LMES_RS02090	COG1126	abc transporter atp-binding protein
LMES_RS02095	COG0765	amino acid transport
LMES_RS02120	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LMES_RS02125	COG1733	regulation of RNA biosynthetic process
LMES_RS02130	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
LMES_RS02135	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LMES_RS02135	COG0072	phenylalanine-tRNA ligase activity
LMES_RS02140	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LMES_RS02145	COG0254	rRNA binding
LMES_RS02150	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LMES_RS02155	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LMES_RS02175	COG2814	Major facilitator Superfamily
LMES_RS02180	COG2003	Belongs to the UPF0758 family
LMES_RS02185	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
LMES_RS02190	COG2131	deaminase
LMES_RS02195	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
LMES_RS02200	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LMES_RS02210	COG4537	Required for transformation and DNA binding
LMES_RS02240	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
LMES_RS02250	COG4975	Glucose uptake
LMES_RS02255	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LMES_RS02290	COG0683	leucine binding
LMES_RS02305	COG0411	ABC transporter
LMES_RS02315	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
LMES_RS02320	COG0351	phosphomethylpyrimidine kinase
LMES_RS02325	COG0352	thiamine-phosphate diphosphorylase activity
LMES_RS02330	COG1012	belongs to the aldehyde dehydrogenase family
LMES_RS02370	COG4493	Belongs to the UPF0637 family
LMES_RS02375	COG0025	NhaP-type Na H and K H
LMES_RS02380	COG1609	Transcriptional regulator
LMES_RS02400	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LMES_RS02410	COG0308	aminopeptidase N
LMES_RS02420	COG2936	dipeptidyl-peptidase activity
LMES_RS02430	COG1263	PTS System
LMES_RS02430	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LMES_RS02430	COG2190	(PTS) system
LMES_RS02435	COG0366	Alpha amylase catalytic
LMES_RS02440	COG2188	Transcriptional regulator
LMES_RS02445	COG1078	dGTPase activity
LMES_RS02455	COG3343	RNA polymerase activity
LMES_RS02465	COG1113	amino acid transport
LMES_RS02470	COG1268	BioY protein
LMES_RS02475	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
LMES_RS02475	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
LMES_RS02480	COG0504	CTP synthase activity
LMES_RS02485	COG0322	excinuclease ABC activity
LMES_RS02490	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
LMES_RS02495	COG0028	Belongs to the TPP enzyme family
LMES_RS02505	COG2309	aminopeptidase activity
LMES_RS02515	COG0673	inositol 2-dehydrogenase activity
LMES_RS02520	COG0513	Belongs to the DEAD box helicase family
LMES_RS02525	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LMES_RS02535	COG0237	dephospho-CoA kinase activity
LMES_RS02545	COG1484	DNA-dependent DNA replication
LMES_RS02570	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
LMES_RS02575	COG0416	fatty acid biosynthetic process
LMES_RS02580	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LMES_RS02585	COG3091	SprT-like family
LMES_RS02590	COG0561	phosphatase activity
LMES_RS02610	COG1609	Transcriptional regulator
LMES_RS02615	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
LMES_RS02615	COG2755	lipolytic protein G-D-S-L family
LMES_RS02620	COG2814	Major facilitator Superfamily
LMES_RS02635	COG3527	Alpha-acetolactate decarboxylase
LMES_RS02640	COG1737	Transcriptional regulator
LMES_RS02645	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
LMES_RS02660	COG0531	amino acid
LMES_RS02670	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LMES_RS02675	COG4472	Bacterial protein of unknown function (DUF965)
LMES_RS02680	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
LMES_RS02685	COG3906	Belongs to the UPF0473 family
LMES_RS02690	COG1271	oxidase subunit
LMES_RS02695	COG1294	oxidase, subunit
LMES_RS02700	COG4988	ABC transporter
LMES_RS02705	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
LMES_RS02710	COG1705	Flagellar rod assembly protein muramidase FlgJ
LMES_RS02715	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LMES_RS02730	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
LMES_RS02745	COG0542	response to heat
LMES_RS02750	COG1077	Cell shape determining protein MreB Mrl
LMES_RS02765	COG0765	amino acid transport
LMES_RS02775	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LMES_RS02785	COG0612	Peptidase, M16
LMES_RS02790	COG0612	Peptidase, M16
LMES_RS02795	COG1426	Protein conserved in bacteria
LMES_RS02800	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
LMES_RS02805	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
LMES_RS02810	COG0745	RESPONSE REGULATOR receiver
LMES_RS02815	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
LMES_RS02830	COG0573	inorganic phosphate transmembrane transporter activity
LMES_RS02835	COG0581	inorganic phosphate transmembrane transporter activity
LMES_RS02840	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
LMES_RS02845	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
LMES_RS02850	COG0704	Plays a role in the regulation of phosphate uptake
LMES_RS02860	COG1950	PFAM Membrane protein of
LMES_RS02865	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
LMES_RS02870	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
LMES_RS02875	COG1210	Utp--glucose-1-phosphate uridylyltransferase
LMES_RS02880	COG0492	ferredoxin-NADP+ reductase activity
LMES_RS02895	COG1063	alcohol dehydrogenase
LMES_RS02900	COG1609	Transcriptional regulator
LMES_RS02910	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LMES_RS02915	COG0335	large ribosomal subunit rRNA binding
LMES_RS02920	COG1719	4-vinyl reductase, 4VR
LMES_RS02925	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
LMES_RS02930	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
LMES_RS02940	COG2255	four-way junction helicase activity
LMES_RS02950	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
LMES_RS02955	COG0584	glycerophosphoryl diester phosphodiesterase
LMES_RS02960	COG0632	four-way junction helicase activity
LMES_RS02965	COG1428	Deoxynucleoside kinase
LMES_RS02970	COG1970	mechanosensitive ion channel activity
LMES_RS02975	COG0577	efflux transmembrane transporter activity
LMES_RS02980	COG1136	(ABC) transporter
LMES_RS02985	COG4684	Psort location CytoplasmicMembrane, score
LMES_RS02990	COG4684	Psort location CytoplasmicMembrane, score
LMES_RS03010	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LMES_RS03015	COG1126	abc transporter atp-binding protein
LMES_RS03020	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
LMES_RS03030	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LMES_RS03040	COG0671	phosphoesterase, PA-phosphatase related
LMES_RS03045	COG0495	leucyl-tRNA aminoacylation
LMES_RS03050	COG2244	polysaccharide biosynthetic process
LMES_RS03065	COG1704	LemA family
LMES_RS03070	COG0501	Belongs to the peptidase M48B family
LMES_RS03075	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
LMES_RS03080	COG1942	4-Oxalocrotonate Tautomerase
LMES_RS03090	COG3237	CsbD-like
LMES_RS03100	COG0517	IMP dehydrogenase activity
LMES_RS03100	COG0516	GMP reductase activity
LMES_RS03105	COG0517	IMP dehydrogenase activity
LMES_RS03105	COG0516	GMP reductase activity
LMES_RS03125	COG3331	DNA recombination
LMES_RS03135	COG4474	Belongs to the UPF0398 family
LMES_RS03140	COG3599	regulation of cell shape
LMES_RS03145	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LMES_RS03150	COG2706	6-phosphogluconolactonase activity
LMES_RS03155	COG0628	permease
LMES_RS03170	COG1674	ftsk spoiiie
LMES_RS03170	COG1280	lysine exporter protein (LysE YggA)
LMES_RS03175	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
LMES_RS03180	COG1113	amino acid transport
LMES_RS03185	COG0586	Pfam SNARE associated Golgi protein
LMES_RS03195	COG3001	Fructosamine kinase
LMES_RS03205	COG2171	N-acyltransferase activity
LMES_RS03210	COG1473	amidohydrolase
LMES_RS03215	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LMES_RS03220	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
LMES_RS03225	COG2137	regulation of response to DNA damage stimulus
LMES_RS03230	COG3557	Belongs to the UPF0374 family
LMES_RS03235	COG0705	Rhomboid family
LMES_RS03245	COG1940	carbohydrate kinase activity
LMES_RS03255	COG2357	RelA SpoT domain protein
LMES_RS03260	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
LMES_RS03265	COG0564	pseudouridine synthase activity
LMES_RS03270	COG2239	Acts as a magnesium transporter
LMES_RS03280	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
LMES_RS03285	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LMES_RS03290	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
LMES_RS03295	COG4589	Belongs to the CDS family
LMES_RS03300	COG0750	zinc metalloprotease
LMES_RS03305	COG0442	prolyl-tRNA aminoacylation
LMES_RS03310	COG2176	DNA-directed DNA polymerase activity
LMES_RS03325	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
LMES_RS03325	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LMES_RS03330	COG1744	ABC transporter substrate-binding protein PnrA-like
LMES_RS03345	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LMES_RS03350	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
LMES_RS03360	COG0667	Aldo Keto reductase
LMES_RS03365	COG0151	Belongs to the GarS family
LMES_RS03370	COG2759	Belongs to the formate--tetrahydrofolate ligase family
LMES_RS03375	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
LMES_RS03380	COG1278	Cold shock
LMES_RS03385	COG0494	nUDIX hydrolase
LMES_RS03395	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
LMES_RS03400	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LMES_RS03405	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LMES_RS03420	COG1621	beta-fructofuranosidase activity
LMES_RS03420	COG3583	domain protein
LMES_RS03420	COG5492	domain, Protein
LMES_RS03425	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LMES_RS03425	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LMES_RS03430	COG3764	Sortase (surface protein transpeptidase)
LMES_RS03440	COG0789	Transcriptional regulator
LMES_RS03445	COG0174	glutamine synthetase
LMES_RS03450	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
LMES_RS03455	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
LMES_RS03460	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
LMES_RS03465	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LMES_RS03475	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LMES_RS03485	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
LMES_RS03490	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
LMES_RS03495	COG0138	bifunctional purine biosynthesis protein purh
LMES_RS03500	COG0420	3'-5' exonuclease activity
LMES_RS03505	COG4717	serine-type aminopeptidase activity
LMES_RS03525	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LMES_RS03535	COG0095	Lipoate-protein ligase
LMES_RS03550	COG0508	dehydrogenase complex catalyzes the overall conversion of
LMES_RS03560	COG2267	carboxylic ester hydrolase activity
LMES_RS03565	COG0584	glycerophosphoryl diester phosphodiesterase
LMES_RS03585	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LMES_RS03590	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
LMES_RS03600	COG0351	phosphomethylpyrimidine kinase
LMES_RS03605	COG1169	isochorismate synthase
LMES_RS03610	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
LMES_RS03630	COG0617	tRNA 3'-terminal CCA addition
LMES_RS03640	COG1307	EDD domain protein, DegV family
LMES_RS03645	COG1957	nucleoside hydrolase
LMES_RS03655	COG2755	lipolytic protein G-D-S-L family
LMES_RS03665	COG4479	Belongs to the UPF0346 family
LMES_RS03670	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
LMES_RS03675	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
LMES_RS03685	COG1122	ATPase activity
LMES_RS03700	COG2384	SAM-dependent methyltransferase
LMES_RS03705	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
LMES_RS03720	COG0587	DNA-directed DNA polymerase activity
LMES_RS03730	COG0004	ammonium transporteR
LMES_RS03735	COG1702	phosphate starvation-inducible protein PhoH
LMES_RS03740	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
LMES_RS03750	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
LMES_RS03755	COG1381	Involved in DNA repair and RecF pathway recombination
LMES_RS03760	COG0252	asparaginase activity
LMES_RS03770	COG0527	aspartate kinase activity
LMES_RS03775	COG0083	homoserine kinase activity
LMES_RS03780	COG0460	homoserine dehydrogenase
LMES_RS03785	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
LMES_RS03790	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LMES_RS03795	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
LMES_RS03800	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LMES_RS03825	COG1609	Transcriptional regulator
LMES_RS03830	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LMES_RS03850	COG0517	IMP dehydrogenase activity
LMES_RS03850	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
LMES_RS03855	COG2877	3-deoxy-8-phosphooctulonate synthase activity
LMES_RS03870	COG1121	(ABC) transporter
LMES_RS03875	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LMES_RS03895	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
LMES_RS03900	COG0415	Belongs to the DNA photolyase family
LMES_RS03905	COG0577	efflux transmembrane transporter activity
LMES_RS03920	COG1033	growth of symbiont in host cell
LMES_RS03920	COG2409	Drug exporters of the RND superfamily
LMES_RS03935	COG0069	glutamate synthase activity
LMES_RS03935	COG0070	glutamate synthase
LMES_RS03935	COG0067	glutamate synthase
LMES_RS03940	COG0493	'glutamate synthase
LMES_RS03955	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LMES_RS03955	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LMES_RS03960	COG0307	riboflavin synthase, alpha
LMES_RS03970	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
LMES_RS03975	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
LMES_RS03980	COG2814	Major facilitator Superfamily
LMES_RS03990	COG1609	Transcriptional regulator
LMES_RS04010	COG0693	protein deglycase activity
LMES_RS04015	COG0745	RESPONSE REGULATOR receiver
LMES_RS04020	COG5002	protein histidine kinase activity
LMES_RS04025	COG1136	(ABC) transporter
LMES_RS04035	COG0583	DNA-binding transcription factor activity
LMES_RS04040	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
LMES_RS04045	COG1045	serine acetyltransferase
LMES_RS04055	COG0667	Aldo Keto reductase
LMES_RS04070	COG1874	Beta-galactosidase
LMES_RS04100	COG0789	Transcriptional regulator
LMES_RS04115	COG1609	Transcriptional regulator
LMES_RS04120	COG2160	L-arabinose isomerase activity
LMES_RS04140	COG1028	Short-chain dehydrogenase reductase Sdr
LMES_RS04150	COG2261	transglycosylase associated protein
LMES_RS04175	COG2261	transglycosylase associated protein
LMES_RS04185	COG2814	Major facilitator Superfamily
LMES_RS04190	COG5039	Polysaccharide pyruvyl transferase
LMES_RS04195	COG1472	Belongs to the glycosyl hydrolase 3 family
LMES_RS04200	COG0431	NADPH-dependent FMN reductase
LMES_RS04220	COG2190	(PTS) system
LMES_RS04220	COG2211	Major facilitator Superfamily
LMES_RS04225	COG1609	Transcriptional regulator
LMES_RS04235	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
LMES_RS04245	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LMES_RS04270	COG1609	Transcriptional regulator
LMES_RS04285	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LMES_RS04295	COG0366	Alpha amylase catalytic
LMES_RS04305	COG0366	Alpha amylase catalytic
LMES_RS04310	COG3711	transcriptional antiterminator
LMES_RS04320	COG2723	6-phospho-beta-galactosidase activity
LMES_RS04330	COG1956	GAF domain-containing protein
LMES_RS04335	COG2244	polysaccharide biosynthetic process
LMES_RS04340	COG1609	Transcriptional regulator
LMES_RS04370	COG1215	transferase activity, transferring glycosyl groups
LMES_RS04385	COG0300	oxidoreductase activity
LMES_RS04395	COG0477	Major facilitator Superfamily
LMES_RS04400	COG1063	alcohol dehydrogenase
LMES_RS04410	COG1129	ABC transporter
LMES_RS04415	COG1573	uracil-dna glycosylase
LMES_RS04420	COG4720	Psort location CytoplasmicMembrane, score
LMES_RS04435	COG0693	protein deglycase activity
LMES_RS04445	COG0436	Aminotransferase
LMES_RS04450	COG1028	Short-chain dehydrogenase reductase Sdr
LMES_RS04455	COG2610	gluconate transmembrane transporter activity
LMES_RS04460	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
LMES_RS04465	COG1619	proteins homologs of microcin C7 resistance protein MccF
LMES_RS04475	COG2723	6-phospho-beta-galactosidase activity
LMES_RS04485	COG3711	transcriptional antiterminator
LMES_RS04485	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LMES_RS04490	COG1447	Phosphotransferase system cellobiose-specific component IIA
LMES_RS04500	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LMES_RS04520	COG1028	Short-chain dehydrogenase reductase Sdr
LMES_RS04530	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
LMES_RS04550	COG2723	6-phospho-beta-galactosidase activity
LMES_RS04565	COG1733	regulation of RNA biosynthetic process
LMES_RS04570	COG1846	Transcriptional regulator
LMES_RS04590	COG1442	glycosyl transferase family 8
LMES_RS04595	COG1121	(ABC) transporter
LMES_RS04600	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LMES_RS04610	COG3527	Alpha-acetolactate decarboxylase
LMES_RS04620	COG0745	RESPONSE REGULATOR receiver
LMES_RS04625	COG5002	protein histidine kinase activity
LMES_RS04645	COG1316	TRANSCRIPTIONal
LMES_RS04650	COG1846	Transcriptional regulator
LMES_RS04655	COG2814	Major facilitator Superfamily
LMES_RS04660	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
LMES_RS04670	COG0656	L-ascorbic acid biosynthetic process
LMES_RS04675	COG0789	Transcriptional regulator
LMES_RS04680	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
LMES_RS04690	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LMES_RS04695	COG0300	oxidoreductase activity
LMES_RS04745	COG2364	Membrane
LMES_RS04750	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LMES_RS04765	COG0028	Belongs to the TPP enzyme family
LMES_RS04770	COG0071	Belongs to the small heat shock protein (HSP20) family
LMES_RS04775	COG0702	epimerase
LMES_RS04785	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LMES_RS04790	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
LMES_RS04800	COG3340	Belongs to the peptidase S51 family
LMES_RS04810	COG0384	phenazine biosynthesis protein PhzF
LMES_RS04820	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LMES_RS04830	COG1846	Transcriptional regulator
LMES_RS04840	COG2826	transposase and inactivated derivatives, IS30 family
LMES_RS04915	COG2814	Major facilitator Superfamily
LMES_RS04960	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
LMES_RS04975	COG0131	Imidazoleglycerol-phosphate dehydratase
LMES_RS04975	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
LMES_RS05010	COG2197	response regulator
LMES_RS05015	COG4585	Histidine kinase
LMES_RS05020	COG2409	Drug exporters of the RND superfamily
LMES_RS05035	COG2814	Major facilitator Superfamily
LMES_RS05045	COG1028	Short-chain dehydrogenase reductase Sdr
LMES_RS05050	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LMES_RS05055	COG2271	Major facilitator Superfamily
LMES_RS05060	COG2022	thiamine diphosphate biosynthetic process
LMES_RS05065	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
LMES_RS05070	COG2022	thiamine diphosphate biosynthetic process
LMES_RS05070	COG2104	thiamine diphosphate biosynthetic process
LMES_RS05075	COG0352	thiamine-phosphate diphosphorylase activity
LMES_RS05080	COG0710	3-dehydroquinate dehydratase activity
LMES_RS05090	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
LMES_RS05095	COG0287	Prephenate dehydrogenase
LMES_RS05100	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
LMES_RS05105	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
LMES_RS05110	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
LMES_RS05115	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
LMES_RS05125	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
LMES_RS05130	COG0512	Glutamine amidotransferase of anthranilate synthase
LMES_RS05135	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
LMES_RS05140	COG0159	tryptophan synthase activity
LMES_RS05150	COG0134	indole-3-glycerol-phosphate synthase activity
LMES_RS05155	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
LMES_RS05180	COG2848	UPF0210 protein
LMES_RS05200	COG3425	synthase
LMES_RS05205	COG0488	(ABC) transporter
LMES_RS05215	COG1385	rRNA (uridine-N3-)-methyltransferase activity
LMES_RS05220	COG2264	protein methyltransferase activity
LMES_RS05240	COG0673	inositol 2-dehydrogenase activity
LMES_RS05245	COG0751	glycine-tRNA ligase activity
LMES_RS05250	COG0752	glycyl-tRNA synthetase alpha subunit
LMES_RS05260	COG0233	cytoplasmic translational termination
LMES_RS05265	COG0528	UMP kinase activity
LMES_RS05270	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
LMES_RS05275	COG0052	Belongs to the universal ribosomal protein uS2 family
LMES_RS05280	COG2827	Endonuclease containing a URI domain
LMES_RS05285	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
LMES_RS05290	COG0204	Acyl-transferase
LMES_RS05295	COG3763	UPF0154 protein
LMES_RS05300	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LMES_RS05305	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
LMES_RS05310	COG0284	orotidine-5'-phosphate decarboxylase activity
LMES_RS05315	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
LMES_RS05320	COG0505	Belongs to the CarA family
LMES_RS05325	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LMES_RS05330	COG0540	Belongs to the ATCase OTCase family
LMES_RS05340	COG3679	Belongs to the UPF0342 family
LMES_RS05345	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LMES_RS05350	COG1438	arginine binding
LMES_RS05355	COG0018	arginyl-trna synthetase
LMES_RS05365	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
LMES_RS05400	COG0220	tRNA (guanine-N7-)-methyltransferase activity
LMES_RS05410	COG1131	(ABC) transporter
LMES_RS05415	COG0537	adenosine 5'-monophosphoramidase activity
LMES_RS05425	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LMES_RS05435	COG0436	Aminotransferase
LMES_RS05440	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LMES_RS05445	COG1126	abc transporter atp-binding protein
LMES_RS05450	COG0765	amino acid transport
LMES_RS05455	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LMES_RS05460	COG0626	cystathionine gamma-synthase activity
LMES_RS05470	COG1028	Short-chain dehydrogenase reductase Sdr
LMES_RS05480	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LMES_RS05485	COG0358	DNA primase activity
LMES_RS05495	COG3716	PTS system mannose fructose sorbose family IID component
LMES_RS05525	COG0758	DNA mediated transformation
LMES_RS05530	COG0488	(ABC) transporter
LMES_RS05535	COG0167	dihydroorotate dehydrogenase activity
LMES_RS05540	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
LMES_RS05545	COG0860	N-Acetylmuramoyl-L-alanine amidase
LMES_RS05555	COG2183	response to ionizing radiation
LMES_RS05565	COG1970	mechanosensitive ion channel activity
LMES_RS05575	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
LMES_RS05580	COG0626	cystathionine gamma-synthase activity
LMES_RS05585	COG1045	serine acetyltransferase
LMES_RS05595	COG0776	regulation of translation
LMES_RS05605	COG0539	negative regulation of cytoplasmic translation
LMES_RS05610	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
LMES_RS05620	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
LMES_RS05625	COG1187	pseudouridine synthase activity
LMES_RS05630	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
LMES_RS05635	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
LMES_RS05645	COG4974	Belongs to the 'phage' integrase family
LMES_RS05650	COG2996	Protein conserved in bacteria
LMES_RS05655	COG1610	YqeY-like protein
LMES_RS05660	COG0828	Belongs to the bacterial ribosomal protein bS21 family
LMES_RS05665	COG0477	Major facilitator Superfamily
LMES_RS05670	COG2508	Transcriptional regulator
LMES_RS05675	COG1113	amino acid transport
LMES_RS05680	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
LMES_RS05685	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
LMES_RS05690	COG0124	histidyl-tRNA synthetase
LMES_RS05695	COG2017	converts alpha-aldose to the beta-anomer
LMES_RS05700	COG2207	Transcriptional regulator
LMES_RS05705	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
LMES_RS05715	COG0667	Aldo Keto reductase
LMES_RS05730	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LMES_RS05735	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LMES_RS05745	COG4470	Protein conserved in bacteria
LMES_RS05750	COG0737	Belongs to the 5'-nucleotidase family
LMES_RS05760	COG0006	proline dipeptidase activity
LMES_RS05765	COG0211	Belongs to the bacterial ribosomal protein bL27 family
LMES_RS05770	COG0261	This protein binds to 23S rRNA in the presence of protein L20
LMES_RS05800	COG1247	-acetyltransferase
LMES_RS05805	COG2962	Rard protein
LMES_RS05830	COG1217	gtp-binding protein TYPA
LMES_RS05835	COG0483	inositol monophosphate 1-phosphatase activity
LMES_RS05840	COG4476	Belongs to the UPF0223 family
LMES_RS05845	COG0242	peptide deformylase activity
LMES_RS05850	COG0484	heat shock protein binding
LMES_RS05855	COG0443	Heat shock 70 kDa protein
LMES_RS05860	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
LMES_RS05865	COG1420	regulation of RNA biosynthetic process
LMES_RS05870	COG0196	riboflavin kinase activity
LMES_RS05875	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
LMES_RS05885	COG0436	Aminotransferase
LMES_RS05890	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
LMES_RS05895	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
LMES_RS05905	COG2740	Nucleic-acid-binding protein implicated in transcription termination
LMES_RS05910	COG0195	Participates in both transcription termination and antitermination
LMES_RS05915	COG0779	Required for maturation of 30S ribosomal subunits
LMES_RS05920	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
LMES_RS05925	COG0267	Belongs to the bacterial ribosomal protein bL33 family
LMES_RS05930	COG1227	inorganic diphosphatase activity
LMES_RS05940	COG0187	DNA topoisomerase II activity
LMES_RS05950	COG1490	D-aminoacyl-tRNA deacylase activity
LMES_RS05955	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LMES_RS05975	COG0505	Belongs to the CarA family
LMES_RS05980	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
LMES_RS05985	COG0564	pseudouridine synthase activity
LMES_RS05995	COG0328	RNA-DNA hybrid ribonuclease activity
LMES_RS06005	COG0436	Aminotransferase
LMES_RS06010	COG0116	Belongs to the methyltransferase superfamily
LMES_RS06025	COG0017	Asparaginyl-tRNA synthetase
LMES_RS06030	COG0436	Aminotransferase
LMES_RS06040	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LMES_RS06040	COG1199	ATP-dependent helicase activity
LMES_RS06060	COG1304	FMN binding
LMES_RS06070	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
LMES_RS06075	COG2116	formate transmembrane transporter activity
LMES_RS06080	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
LMES_RS06085	COG0716	FMN binding
LMES_RS06095	COG1216	Glycosyl transferase, family 2
LMES_RS06115	COG0463	Glycosyl transferase, family 2
LMES_RS06120	COG0562	UDP-galactopyranose mutase
LMES_RS06170	COG0366	Alpha amylase catalytic
LMES_RS06170	COG5263	repeat protein
LMES_RS06180	COG5263	repeat protein
LMES_RS06180	COG0366	Alpha amylase catalytic
LMES_RS06230	COG1088	dTDP-glucose 4,6-dehydratase activity
LMES_RS06240	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
LMES_RS06265	COG1216	Glycosyl transferase, family 2
LMES_RS06265	COG1442	glycosyl transferase family 8
LMES_RS06275	COG0438	transferase activity, transferring glycosyl groups
LMES_RS06290	COG1216	Glycosyl transferase, family 2
LMES_RS06295	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
LMES_RS06300	COG0489	protein tyrosine kinase activity
LMES_RS06315	COG0024	Methionine aminopeptidase
LMES_RS06320	COG1316	TRANSCRIPTIONal
LMES_RS06325	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
LMES_RS06330	COG1114	Component of the transport system for branched-chain amino acids
LMES_RS06335	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
LMES_RS06340	COG0291	Belongs to the bacterial ribosomal protein bL35 family
LMES_RS06360	COG0333	Belongs to the bacterial ribosomal protein bL32 family
LMES_RS06365	COG3142	Participates in the control of copper homeostasis
LMES_RS06410	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
LMES_RS06420	COG0165	Argininosuccinate lyase
LMES_RS06425	COG0137	argininosuccinate synthase activity
LMES_RS06430	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
LMES_RS06435	COG0217	transcriptional regulatory protein
LMES_RS06445	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LMES_RS06450	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
LMES_RS06465	COG0280	phosphate acetyltransferase
LMES_RS06470	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
LMES_RS06500	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LMES_RS06505	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
LMES_RS06505	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
LMES_RS06510	COG1234	tRNA 3'-trailer cleavage
LMES_RS06515	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LMES_RS06520	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
LMES_RS06525	COG0336	Belongs to the RNA methyltransferase TrmD family
LMES_RS06530	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
LMES_RS06540	COG1074	ATP-dependent DNA helicase activity
LMES_RS06545	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
LMES_RS06560	COG0228	four-way junction DNA binding
LMES_RS06585	COG0762	integral membrane protein
LMES_RS06590	COG1799	cell septum assembly
LMES_RS06605	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
LMES_RS06610	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
LMES_RS06615	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
LMES_RS06620	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LMES_RS06625	COG0768	penicillin binding
LMES_RS06635	COG0275	rRNA processing
LMES_RS06640	COG2001	Belongs to the MraZ family
LMES_RS06655	COG1461	Dihydroxyacetone kinase
LMES_RS06665	COG0227	Belongs to the bacterial ribosomal protein bL28 family
LMES_RS06670	COG3118	belongs to the thioredoxin family
LMES_RS06675	COG1564	THIamine pyrophosphokinase
LMES_RS06680	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
LMES_RS06685	COG1162	GTPase activity
LMES_RS06690	COG2815	serine threonine protein kinase
LMES_RS06690	COG0515	serine threonine protein kinase
LMES_RS06695	COG0631	protein serine/threonine phosphatase activity
LMES_RS06700	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LMES_RS06700	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LMES_RS06705	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
LMES_RS06710	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
LMES_RS06725	COG3201	nicotinamide mononucleotide transporter
LMES_RS06730	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LMES_RS06735	COG0218	Necessary for normal cell division and for the maintenance of normal septation
LMES_RS06740	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
LMES_RS06750	COG4974	Belongs to the 'phage' integrase family
LMES_RS06765	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
LMES_RS06770	COG0544	peptidyl-prolyl cis-trans isomerase activity
LMES_RS06790	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
LMES_RS06795	COG0708	Exodeoxyribonuclease III
LMES_RS06800	COG2176	DNA-directed DNA polymerase activity
LMES_RS06805	COG0456	acetyltransferase
LMES_RS06810	COG0802	atpase or kinase
LMES_RS06845	COG0602	queuosine metabolic process
LMES_RS06850	COG1328	CTP reductase activity
LMES_RS06855	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
LMES_RS06860	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
LMES_RS06875	COG4172	Belongs to the ABC transporter superfamily
LMES_RS06890	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LMES_RS06895	COG0140	phosphoribosyl-ATP diphosphatase activity
LMES_RS06900	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
LMES_RS06905	COG0107	imidazoleglycerol-phosphate synthase activity
LMES_RS06910	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
LMES_RS06920	COG0131	Imidazoleglycerol-phosphate dehydratase
LMES_RS06925	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
LMES_RS06930	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
LMES_RS06935	COG2199	diguanylate cyclase activity
LMES_RS06955	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
LMES_RS06960	COG0561	phosphatase activity
LMES_RS06970	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
LMES_RS06980	COG0552	protein localization to endoplasmic reticulum
LMES_RS06985	COG1196	nuclear chromosome segregation
LMES_RS06990	COG0571	ribonuclease III activity
LMES_RS06995	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LMES_RS07015	COG0812	UDP-N-acetylmuramate dehydrogenase activity
LMES_RS07020	COG0105	UTP biosynthetic process
LMES_RS07025	COG4807	Protein conserved in bacteria
LMES_RS07030	COG3237	CsbD-like
LMES_RS07035	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
LMES_RS07040	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
LMES_RS07045	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LMES_RS07050	COG1597	lipid kinase activity
LMES_RS07060	COG0154	amidase activity
LMES_RS07065	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LMES_RS07070	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
LMES_RS07075	COG0268	Binds directly to 16S ribosomal RNA
LMES_RS07080	COG0513	Belongs to the DEAD box helicase family
LMES_RS07085	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
LMES_RS07090	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LMES_RS07095	COG1466	dna polymerase III delta subunit
LMES_RS07100	COG2333	competence protein COMEC
LMES_RS07100	COG0658	competence protein
LMES_RS07105	COG1596	polysaccharide export
LMES_RS07105	COG1555	photosystem II stabilization
LMES_RS07110	COG3480	Lon protease (S16) C-terminal proteolytic domain
LMES_RS07115	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
LMES_RS07120	COG0742	ribosomal rna small subunit methyltransferase
LMES_RS07125	COG4471	UPF0298 protein
LMES_RS07130	COG0772	Belongs to the SEDS family
LMES_RS07135	COG1363	Peptidase, m42
LMES_RS07140	COG0588	phosphoglycerate mutase activity
LMES_RS07145	COG0534	Mate efflux family protein
LMES_RS07150	COG2252	PERMEase
LMES_RS07155	COG0497	DNA recombination
LMES_RS07160	COG1438	arginine binding
LMES_RS07165	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
LMES_RS07170	COG0142	geranyltranstransferase activity
LMES_RS07175	COG1722	exodeoxyribonuclease VII activity
LMES_RS07180	COG1570	exodeoxyribonuclease VII activity
LMES_RS07195	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
LMES_RS07200	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LMES_RS07205	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LMES_RS07210	COG1121	(ABC) transporter
LMES_RS07220	COG4466	Protein conserved in bacteria
LMES_RS07225	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
LMES_RS07230	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
LMES_RS07235	COG0084	hydrolase, TatD family'
LMES_RS07240	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LMES_RS07250	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
LMES_RS07260	COG1611	Belongs to the LOG family
LMES_RS07265	COG5503	Protein of unknown function (DUF1447)
LMES_RS07370	COG0740	serine-type endopeptidase activity
LMES_RS07540	COG3152	Membrane
LMES_RS07550	COG1892	Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four- carbon dicarboxylic acid source for the tricarboxylic acid cycle
LMES_RS07565	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
LMES_RS07575	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
LMES_RS07580	COG0584	glycerophosphoryl diester phosphodiesterase
LMES_RS07595	COG4862	establishment of competence for transformation
LMES_RS07600	COG1393	Belongs to the ArsC family
LMES_RS07630	COG1098	S1 RNA binding domain
LMES_RS07640	COG1758	RNA polymerase activity
LMES_RS07645	COG0194	GDP metabolic process
LMES_RS07665	COG1193	negative regulation of DNA recombination
LMES_RS07685	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
LMES_RS07700	COG1418	mRNA catabolic process
LMES_RS07705	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
LMES_RS07710	COG0557	exoribonuclease II activity
LMES_RS07720	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LMES_RS07725	COG0706	membrane insertase activity
LMES_RS07730	COG1254	Belongs to the acylphosphatase family
LMES_RS07735	COG5002	protein histidine kinase activity
LMES_RS07740	COG0745	RESPONSE REGULATOR receiver
LMES_RS07750	COG1323	Belongs to the UPF0348 family
LMES_RS07755	COG2226	methyltransferase
LMES_RS07760	COG0799	negative regulation of ribosome biogenesis
LMES_RS07765	COG1713	HD superfamily hydrolase involved in NAD metabolism
LMES_RS07770	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
LMES_RS07775	COG1534	Rna-binding protein
LMES_RS07780	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
LMES_RS07785	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
LMES_RS07810	COG1959	2 iron, 2 sulfur cluster binding
LMES_RS07815	COG0366	Alpha amylase catalytic
LMES_RS07815	COG5263	repeat protein
LMES_RS07840	COG5263	repeat protein
LMES_RS07840	COG0366	Alpha amylase catalytic
LMES_RS07870	COG2323	membrane
LMES_RS07890	COG0459	protein refolding
LMES_RS07895	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
LMES_RS07915	COG3715	PTS system
LMES_RS07930	COG0778	Nitroreductase
LMES_RS07940	COG0561	phosphatase activity
LMES_RS07950	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
LMES_RS07955	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
LMES_RS07970	COG1214	PFAM Peptidase M22, glycoprotease
LMES_RS07975	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LMES_RS07985	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
LMES_RS07990	COG0009	L-threonylcarbamoyladenylate synthase
LMES_RS07995	COG2890	protein-(glutamine-N5) methyltransferase activity
LMES_RS08000	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
LMES_RS08005	COG1435	thymidine kinase activity
LMES_RS08010	COG0791	NLP P60 protein
LMES_RS08010	COG3883	PFAM NLP P60 protein
LMES_RS08015	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
LMES_RS08020	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LMES_RS08025	COG3442	glutamine amidotransferase
LMES_RS08030	COG0531	amino acid
LMES_RS08040	COG0628	permease
LMES_RS08050	COG0833	amino acid
LMES_RS08055	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
LMES_RS08060	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
LMES_RS08065	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
LMES_RS08075	COG2873	o-acetylhomoserine
LMES_RS08080	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
LMES_RS08085	COG1854	S-ribosylhomocysteine lyase activity
LMES_RS08090	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
LMES_RS08095	COG0626	cystathionine gamma-synthase activity
LMES_RS08100	COG0626	cystathionine gamma-synthase activity
LMES_RS08105	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
LMES_RS08110	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LMES_RS08115	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LMES_RS08120	COG5002	protein histidine kinase activity
LMES_RS08125	COG0745	RESPONSE REGULATOR receiver
LMES_RS08130	COG2337	Toxic component of a toxin-antitoxin (TA) module
LMES_RS08135	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LMES_RS08140	COG0736	holo-[acyl-carrier-protein] synthase activity
LMES_RS08145	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
LMES_RS08150	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LMES_RS08155	COG1696	Membrane protein involved in D-alanine export
LMES_RS08160	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LMES_RS08185	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LMES_RS08190	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
LMES_RS08195	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
LMES_RS08200	COG0085	RNA polymerase activity
LMES_RS08265	COG0436	Aminotransferase
LMES_RS08270	COG0194	GDP metabolic process
LMES_RS08275	COG0531	amino acid
LMES_RS08280	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
LMES_RS08285	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
LMES_RS08295	COG2211	Major facilitator Superfamily
LMES_RS08300	COG5506	Protein of unknown function (DUF1694)
LMES_RS08305	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
LMES_RS08315	COG0833	amino acid
LMES_RS08325	COG1316	TRANSCRIPTIONal
LMES_RS08330	COG0531	amino acid
LMES_RS08340	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
LMES_RS08355	COG0628	permease
LMES_RS08360	COG1194	a g-specific adenine glycosylase
LMES_RS08365	COG2814	Major facilitator Superfamily
LMES_RS08370	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
LMES_RS08380	COG1902	pentaerythritol trinitrate reductase activity
LMES_RS08385	COG1388	LysM domain
LMES_RS08385	COG1705	Flagellar rod assembly protein muramidase FlgJ
LMES_RS08390	COG0355	proton-transporting ATP synthase activity, rotational mechanism
LMES_RS08395	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
LMES_RS08400	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
LMES_RS08405	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
LMES_RS08410	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LMES_RS08415	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
LMES_RS08420	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LMES_RS08425	COG0356	it plays a direct role in the translocation of protons across the membrane
LMES_RS08435	COG0588	phosphoglycerate mutase activity
LMES_RS08440	COG1278	Cold shock
LMES_RS08450	COG2814	Major facilitator Superfamily
LMES_RS08460	COG3973	AAA domain
LMES_RS08525	COG1511	domain protein
LMES_RS08525	COG1511	domain protein
LMES_RS08530	COG1309	transcriptional regulator
LMES_RS08540	COG0697	spore germination
LMES_RS08550	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LMES_RS08635	COG0488	(ABC) transporter
LMES_RS08655	COG1064	alcohol dehydrogenase
LMES_RS08660	COG2814	Major facilitator Superfamily
LMES_RS08665	COG0126	phosphoglycerate kinase activity
LMES_RS08695	COG3590	peptidase
LMES_RS08700	COG4608	Belongs to the ABC transporter superfamily
LMES_RS08705	COG0444	Belongs to the ABC transporter superfamily
LMES_RS08710	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LMES_RS08715	COG0601	transmembrane transport
LMES_RS08720	COG4166	transmembrane transport
LMES_RS08725	COG0765	amino acid transport
LMES_RS08730	COG0765	amino acid transport
LMES_RS08735	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LMES_RS08740	COG1126	abc transporter atp-binding protein
LMES_RS08745	COG1132	(ABC) transporter
LMES_RS08750	COG1132	(ABC) transporter
LMES_RS08760	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
LMES_RS08765	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LMES_RS08770	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
LMES_RS08775	COG1959	2 iron, 2 sulfur cluster binding
LMES_RS08780	COG1511	domain protein
LMES_RS08785	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
LMES_RS08790	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LMES_RS08810	COG0745	RESPONSE REGULATOR receiver
LMES_RS08815	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
LMES_RS08830	COG0473	3-isopropylmalate dehydrogenase activity
LMES_RS08840	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
LMES_RS08845	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
LMES_RS08855	COG0028	Belongs to the TPP enzyme family
LMES_RS08860	COG1119	ATPase activity
LMES_RS08865	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
LMES_RS08870	COG2188	Transcriptional regulator
LMES_RS08875	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
LMES_RS08885	COG0305	Participates in initiation and elongation during chromosome replication
LMES_RS08890	COG0359	binds to the 23S rRNA
LMES_RS08900	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
LMES_RS08905	COG0629	single-stranded DNA binding
LMES_RS08910	COG0360	Binds together with S18 to 16S ribosomal RNA
LMES_RS08915	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LMES_RS08925	COG1122	ATPase activity
LMES_RS08930	COG4720	Psort location CytoplasmicMembrane, score
LMES_RS08940	COG0514	ATP-dependent DNA helicase (RecQ)
LMES_RS09000	COG0235	Class ii aldolase
LMES_RS09005	COG3623	hexulose-6-phosphate isomerase
LMES_RS09040	COG0561	phosphatase activity
LMES_RS09065	COG2814	Major facilitator Superfamily
LMES_RS09075	COG0583	DNA-binding transcription factor activity
LMES_RS09080	COG1113	amino acid transport
LMES_RS09085	COG1757	Na H antiporter
LMES_RS09095	COG1902	pentaerythritol trinitrate reductase activity
LMES_RS09100	COG1733	regulation of RNA biosynthetic process
LMES_RS09105	COG0667	Aldo Keto reductase
LMES_RS09115	COG0667	Aldo Keto reductase
LMES_RS09125	COG2814	Major facilitator Superfamily
LMES_RS09135	COG1686	Belongs to the peptidase S11 family
LMES_RS09145	COG0803	Belongs to the bacterial solute-binding protein 9 family
LMES_RS09150	COG2226	methyltransferase
LMES_RS09155	COG0318	PFAM AMP-dependent synthetase and ligase
LMES_RS09165	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
LMES_RS09190	COG0477	Major facilitator Superfamily
LMES_RS09195	COG0066	3-isopropylmalate dehydratase activity
LMES_RS09200	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
LMES_RS09205	COG0473	3-isopropylmalate dehydrogenase activity
LMES_RS09215	COG2151	metal-sulfur cluster biosynthetic enzyme
LMES_RS09220	COG0719	Fe-S assembly protein
LMES_RS09230	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
LMES_RS09235	COG0719	Fe-S assembly protein
LMES_RS09240	COG0396	ATPase activity
LMES_RS09250	COG0129	dihydroxy-acid dehydratase activity
LMES_RS09255	COG2151	metal-sulfur cluster biosynthetic enzyme
LMES_RS09270	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
LMES_RS09285	COG1983	PspC domain protein
LMES_RS09300	COG0577	efflux transmembrane transporter activity
LMES_RS09305	COG1136	(ABC) transporter
LMES_RS09335	COG2855	membrane
LMES_RS09340	COG0583	DNA-binding transcription factor activity
LMES_RS09345	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LMES_RS09365	COG0706	membrane insertase activity
LMES_RS09370	COG0594	ribonuclease P activity
LMES_RS09375	COG0230	Belongs to the bacterial ribosomal protein bL34 family
LMES_RS09380	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LMES_RS09385	COG0446	pyridine nucleotide-disulphide oxidoreductase
LMES_RS09395	COG2084	Dehydrogenase
LMES_RS09400	COG0561	phosphatase activity
LMES_RS09440	COG1215	transferase activity, transferring glycosyl groups