locus-tag	class	description
C7M45_RS00015	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C7M45_RS00025	COG0697	spore germination
C7M45_RS00035	COG1309	transcriptional regulator
C7M45_RS00040	COG1511	domain protein
C7M45_RS00040	COG1511	domain protein
C7M45_RS00105	COG3973	AAA domain
C7M45_RS00115	COG2814	Major facilitator Superfamily
C7M45_RS00125	COG1278	Cold shock
C7M45_RS00130	COG0588	phosphoglycerate mutase activity
C7M45_RS00140	COG0356	it plays a direct role in the translocation of protons across the membrane
C7M45_RS00145	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C7M45_RS00150	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C7M45_RS00155	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C7M45_RS00160	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C7M45_RS00165	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C7M45_RS00170	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C7M45_RS00175	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C7M45_RS00180	COG1388	LysM domain
C7M45_RS00180	COG1705	Flagellar rod assembly protein muramidase FlgJ
C7M45_RS00185	COG1902	pentaerythritol trinitrate reductase activity
C7M45_RS00195	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C7M45_RS00200	COG2814	Major facilitator Superfamily
C7M45_RS00205	COG1194	a g-specific adenine glycosylase
C7M45_RS00210	COG0628	permease
C7M45_RS00225	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C7M45_RS00235	COG0531	amino acid
C7M45_RS00240	COG1316	TRANSCRIPTIONal
C7M45_RS00250	COG0833	amino acid
C7M45_RS00265	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C7M45_RS00270	COG5506	Protein of unknown function (DUF1694)
C7M45_RS00275	COG2211	Major facilitator Superfamily
C7M45_RS00285	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C7M45_RS00290	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
C7M45_RS00295	COG0531	amino acid
C7M45_RS00300	COG0194	GDP metabolic process
C7M45_RS00305	COG0436	Aminotransferase
C7M45_RS00370	COG0085	RNA polymerase activity
C7M45_RS00375	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C7M45_RS00380	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
C7M45_RS00385	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C7M45_RS00410	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C7M45_RS00415	COG1696	Membrane protein involved in D-alanine export
C7M45_RS00420	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C7M45_RS00425	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
C7M45_RS00430	COG0736	holo-[acyl-carrier-protein] synthase activity
C7M45_RS00435	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C7M45_RS00440	COG2337	Toxic component of a toxin-antitoxin (TA) module
C7M45_RS00445	COG0745	RESPONSE REGULATOR receiver
C7M45_RS00450	COG5002	protein histidine kinase activity
C7M45_RS00455	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C7M45_RS00460	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C7M45_RS00465	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
C7M45_RS00470	COG0626	cystathionine gamma-synthase activity
C7M45_RS00475	COG0626	cystathionine gamma-synthase activity
C7M45_RS00480	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C7M45_RS00485	COG1854	S-ribosylhomocysteine lyase activity
C7M45_RS00490	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C7M45_RS00505	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C7M45_RS00510	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
C7M45_RS00515	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C7M45_RS00520	COG0833	amino acid
C7M45_RS00525	COG2040	homocysteine
C7M45_RS00530	COG0628	permease
C7M45_RS00540	COG0531	amino acid
C7M45_RS00545	COG3442	glutamine amidotransferase
C7M45_RS00550	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C7M45_RS00555	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C7M45_RS00560	COG0791	NLP P60 protein
C7M45_RS00560	COG3883	PFAM NLP P60 protein
C7M45_RS00565	COG1435	thymidine kinase activity
C7M45_RS00570	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C7M45_RS00575	COG2890	protein-(glutamine-N5) methyltransferase activity
C7M45_RS00580	COG0009	L-threonylcarbamoyladenylate synthase
C7M45_RS00585	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
C7M45_RS00595	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C7M45_RS00600	COG1214	PFAM Peptidase M22, glycoprotease
C7M45_RS00615	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C7M45_RS00620	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
C7M45_RS00630	COG0561	phosphatase activity
C7M45_RS00640	COG0778	Nitroreductase
C7M45_RS00645	COG1482	cell wall glycoprotein biosynthetic process
C7M45_RS00655	COG3715	PTS system
C7M45_RS00660	COG3716	PTS system mannose fructose sorbose family IID component
C7M45_RS00675	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C7M45_RS00680	COG0459	protein refolding
C7M45_RS00700	COG2323	membrane
C7M45_RS00755	COG5263	repeat protein
C7M45_RS00755	COG0366	Alpha amylase catalytic
C7M45_RS00760	COG1959	2 iron, 2 sulfur cluster binding
C7M45_RS00785	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
C7M45_RS00790	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
C7M45_RS00795	COG1534	Rna-binding protein
C7M45_RS00800	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C7M45_RS00805	COG1713	HD superfamily hydrolase involved in NAD metabolism
C7M45_RS00810	COG0799	negative regulation of ribosome biogenesis
C7M45_RS00815	COG2226	methyltransferase
C7M45_RS00820	COG1323	Belongs to the UPF0348 family
C7M45_RS00830	COG0745	RESPONSE REGULATOR receiver
C7M45_RS00835	COG5002	protein histidine kinase activity
C7M45_RS00840	COG1254	Belongs to the acylphosphatase family
C7M45_RS00845	COG0706	membrane insertase activity
C7M45_RS00850	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C7M45_RS00860	COG0557	exoribonuclease II activity
C7M45_RS00865	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
C7M45_RS00870	COG1418	mRNA catabolic process
C7M45_RS00885	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C7M45_RS00905	COG1193	negative regulation of DNA recombination
C7M45_RS00925	COG0194	GDP metabolic process
C7M45_RS00930	COG1758	RNA polymerase activity
C7M45_RS00940	COG1098	S1 RNA binding domain
C7M45_RS00970	COG1393	Belongs to the ArsC family
C7M45_RS00975	COG4862	establishment of competence for transformation
C7M45_RS00990	COG0584	glycerophosphoryl diester phosphodiesterase
C7M45_RS00995	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C7M45_RS01005	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C7M45_RS01020	COG1892	Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four- carbon dicarboxylic acid source for the tricarboxylic acid cycle
C7M45_RS01030	COG3152	Membrane
C7M45_RS01230	COG0740	serine-type endopeptidase activity
C7M45_RS01345	COG1611	Belongs to the LOG family
C7M45_RS01355	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C7M45_RS01365	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C7M45_RS01370	COG0084	hydrolase, TatD family'
C7M45_RS01375	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
C7M45_RS01380	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C7M45_RS01385	COG4466	Protein conserved in bacteria
C7M45_RS01395	COG1121	(ABC) transporter
C7M45_RS01400	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C7M45_RS01405	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C7M45_RS01410	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C7M45_RS01425	COG1570	exodeoxyribonuclease VII activity
C7M45_RS01430	COG1722	exodeoxyribonuclease VII activity
C7M45_RS01435	COG0142	geranyltranstransferase activity
C7M45_RS01440	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
C7M45_RS01445	COG1438	arginine binding
C7M45_RS01450	COG0497	DNA recombination
C7M45_RS01455	COG2252	PERMEase
C7M45_RS01460	COG0534	Mate efflux family protein
C7M45_RS01465	COG0588	phosphoglycerate mutase activity
C7M45_RS01470	COG1363	Peptidase, m42
C7M45_RS01475	COG0772	Belongs to the SEDS family
C7M45_RS01480	COG4471	UPF0298 protein
C7M45_RS01485	COG0742	ribosomal rna small subunit methyltransferase
C7M45_RS01490	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C7M45_RS01495	COG3480	Lon protease (S16) C-terminal proteolytic domain
C7M45_RS01500	COG1555	photosystem II stabilization
C7M45_RS01500	COG1596	polysaccharide export
C7M45_RS01505	COG0658	competence protein
C7M45_RS01505	COG2333	competence protein COMEC
C7M45_RS01510	COG1466	dna polymerase III delta subunit
C7M45_RS01515	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C7M45_RS01520	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
C7M45_RS01525	COG0513	Belongs to the DEAD box helicase family
C7M45_RS01530	COG0268	Binds directly to 16S ribosomal RNA
C7M45_RS01535	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C7M45_RS01540	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C7M45_RS01545	COG0154	amidase activity
C7M45_RS01550	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C7M45_RS01555	COG1597	lipid kinase activity
C7M45_RS01560	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C7M45_RS01565	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
C7M45_RS01570	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
C7M45_RS01575	COG3237	CsbD-like
C7M45_RS01580	COG4807	Protein conserved in bacteria
C7M45_RS01585	COG0105	UTP biosynthetic process
C7M45_RS01590	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C7M45_RS01610	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C7M45_RS01615	COG0571	ribonuclease III activity
C7M45_RS01620	COG1196	nuclear chromosome segregation
C7M45_RS01625	COG0552	protein localization to endoplasmic reticulum
C7M45_RS01635	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C7M45_RS01645	COG0561	phosphatase activity
C7M45_RS01650	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
C7M45_RS01670	COG2199	diguanylate cyclase activity
C7M45_RS01680	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C7M45_RS01685	COG0131	Imidazoleglycerol-phosphate dehydratase
C7M45_RS01695	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
C7M45_RS01700	COG0107	imidazoleglycerol-phosphate synthase activity
C7M45_RS01705	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C7M45_RS01710	COG0140	phosphoribosyl-ATP diphosphatase activity
C7M45_RS01715	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C7M45_RS01730	COG4172	Belongs to the ABC transporter superfamily
C7M45_RS01745	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C7M45_RS01750	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
C7M45_RS01755	COG1328	CTP reductase activity
C7M45_RS01760	COG0602	queuosine metabolic process
C7M45_RS01795	COG0802	atpase or kinase
C7M45_RS01800	COG0456	acetyltransferase
C7M45_RS01805	COG2176	DNA-directed DNA polymerase activity
C7M45_RS01810	COG0708	Exodeoxyribonuclease III
C7M45_RS01815	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C7M45_RS01835	COG0544	peptidyl-prolyl cis-trans isomerase activity
C7M45_RS01840	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
C7M45_RS01855	COG4974	Belongs to the 'phage' integrase family
C7M45_RS01865	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C7M45_RS01870	COG0218	Necessary for normal cell division and for the maintenance of normal septation
C7M45_RS01875	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C7M45_RS01880	COG3201	nicotinamide mononucleotide transporter
C7M45_RS01895	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C7M45_RS01900	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C7M45_RS01905	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C7M45_RS01905	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C7M45_RS01910	COG0631	protein serine/threonine phosphatase activity
C7M45_RS01915	COG0515	serine threonine protein kinase
C7M45_RS01915	COG2815	serine threonine protein kinase
C7M45_RS01920	COG1162	GTPase activity
C7M45_RS01925	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C7M45_RS01930	COG1564	THIamine pyrophosphokinase
C7M45_RS01935	COG3118	belongs to the thioredoxin family
C7M45_RS01940	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C7M45_RS01950	COG1461	Dihydroxyacetone kinase
C7M45_RS01965	COG2001	Belongs to the MraZ family
C7M45_RS01970	COG0275	rRNA processing
C7M45_RS01985	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C7M45_RS01990	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C7M45_RS01995	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C7M45_RS02000	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
C7M45_RS02015	COG1799	cell septum assembly
C7M45_RS02020	COG0762	integral membrane protein
C7M45_RS02045	COG0228	four-way junction DNA binding
C7M45_RS02060	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
C7M45_RS02065	COG1074	ATP-dependent DNA helicase activity
C7M45_RS02075	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C7M45_RS02080	COG0336	Belongs to the RNA methyltransferase TrmD family
C7M45_RS02085	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C7M45_RS02090	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C7M45_RS02095	COG1234	tRNA 3'-trailer cleavage
C7M45_RS02100	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
C7M45_RS02100	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
C7M45_RS02105	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C7M45_RS02135	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C7M45_RS02140	COG0280	phosphate acetyltransferase
C7M45_RS02150	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
C7M45_RS02155	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C7M45_RS02165	COG0217	transcriptional regulatory protein
C7M45_RS02170	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C7M45_RS02175	COG0137	argininosuccinate synthase activity
C7M45_RS02180	COG0165	Argininosuccinate lyase
C7M45_RS02190	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
C7M45_RS02220	COG0450	alkyl hydroperoxide reductase
C7M45_RS02235	COG3142	Participates in the control of copper homeostasis
C7M45_RS02240	COG0333	Belongs to the bacterial ribosomal protein bL32 family
C7M45_RS02260	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C7M45_RS02265	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C7M45_RS02270	COG1114	Component of the transport system for branched-chain amino acids
C7M45_RS02275	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
C7M45_RS02280	COG1316	TRANSCRIPTIONal
C7M45_RS02285	COG0024	Methionine aminopeptidase
C7M45_RS02300	COG0489	protein tyrosine kinase activity
C7M45_RS02305	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C7M45_RS02315	COG3475	LICD family
C7M45_RS02320	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
C7M45_RS02350	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
C7M45_RS02360	COG1088	dTDP-glucose 4,6-dehydratase activity
C7M45_RS02365	COG1091	dTDP-4-dehydrorhamnose reductase activity
C7M45_RS02410	COG1621	beta-fructofuranosidase activity
C7M45_RS02430	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C7M45_RS02450	COG0562	UDP-galactopyranose mutase
C7M45_RS02455	COG0463	Glycosyl transferase, family 2
C7M45_RS02475	COG1216	Glycosyl transferase, family 2
C7M45_RS02485	COG0716	FMN binding
C7M45_RS02490	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C7M45_RS02495	COG2116	formate transmembrane transporter activity
C7M45_RS02500	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C7M45_RS02510	COG1304	FMN binding
C7M45_RS02530	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C7M45_RS02530	COG1199	ATP-dependent helicase activity
C7M45_RS02545	COG0017	Asparaginyl-tRNA synthetase
C7M45_RS02560	COG0116	Belongs to the methyltransferase superfamily
C7M45_RS02565	COG0436	Aminotransferase
C7M45_RS02575	COG0328	RNA-DNA hybrid ribonuclease activity
C7M45_RS02585	COG0564	pseudouridine synthase activity
C7M45_RS02590	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
C7M45_RS02595	COG0505	Belongs to the CarA family
C7M45_RS02615	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C7M45_RS02620	COG1490	D-aminoacyl-tRNA deacylase activity
C7M45_RS02630	COG0187	DNA topoisomerase II activity
C7M45_RS02640	COG1227	inorganic diphosphatase activity
C7M45_RS02645	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C7M45_RS02650	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C7M45_RS02655	COG0779	Required for maturation of 30S ribosomal subunits
C7M45_RS02660	COG0195	Participates in both transcription termination and antitermination
C7M45_RS02665	COG2740	Nucleic-acid-binding protein implicated in transcription termination
C7M45_RS02675	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C7M45_RS02680	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C7M45_RS02685	COG0436	Aminotransferase
C7M45_RS02695	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C7M45_RS02700	COG0196	riboflavin kinase activity
C7M45_RS02705	COG1420	regulation of RNA biosynthetic process
C7M45_RS02710	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C7M45_RS02715	COG0443	Heat shock 70 kDa protein
C7M45_RS02720	COG0484	heat shock protein binding
C7M45_RS02725	COG0242	peptide deformylase activity
C7M45_RS02730	COG4476	Belongs to the UPF0223 family
C7M45_RS02735	COG0483	inositol monophosphate 1-phosphatase activity
C7M45_RS02760	COG2076	Multidrug Resistance protein
C7M45_RS02770	COG2962	Rard protein
C7M45_RS02775	COG1247	-acetyltransferase
C7M45_RS02810	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C7M45_RS02815	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C7M45_RS02820	COG0006	proline dipeptidase activity
C7M45_RS02830	COG0737	Belongs to the 5'-nucleotidase family
C7M45_RS02835	COG4470	Protein conserved in bacteria
C7M45_RS02845	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C7M45_RS02850	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C7M45_RS02860	COG3250	beta-galactosidase activity
C7M45_RS02865	COG0667	Aldo Keto reductase
C7M45_RS02875	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
C7M45_RS02880	COG2207	Transcriptional regulator
C7M45_RS02885	COG2017	converts alpha-aldose to the beta-anomer
C7M45_RS02890	COG0124	histidyl-tRNA synthetase
C7M45_RS02895	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C7M45_RS02900	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C7M45_RS02905	COG1113	amino acid transport
C7M45_RS02910	COG2508	Transcriptional regulator
C7M45_RS02915	COG0477	Major facilitator Superfamily
C7M45_RS02920	COG0828	Belongs to the bacterial ribosomal protein bS21 family
C7M45_RS02925	COG1610	YqeY-like protein
C7M45_RS02930	COG2996	Protein conserved in bacteria
C7M45_RS02935	COG4974	Belongs to the 'phage' integrase family
C7M45_RS02945	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
C7M45_RS02950	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C7M45_RS02955	COG1187	pseudouridine synthase activity
C7M45_RS02960	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
C7M45_RS02970	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C7M45_RS02975	COG0539	negative regulation of cytoplasmic translation
C7M45_RS02980	COG1160	GTP binding
C7M45_RS02985	COG0776	regulation of translation
C7M45_RS02995	COG1045	serine acetyltransferase
C7M45_RS03000	COG0626	cystathionine gamma-synthase activity
C7M45_RS03005	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C7M45_RS03015	COG1970	mechanosensitive ion channel activity
C7M45_RS03025	COG2183	response to ionizing radiation
C7M45_RS03035	COG0860	N-Acetylmuramoyl-L-alanine amidase
C7M45_RS03040	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C7M45_RS03045	COG0167	dihydroorotate dehydrogenase activity
C7M45_RS03050	COG0488	(ABC) transporter
C7M45_RS03055	COG0758	DNA mediated transformation
C7M45_RS03085	COG3716	PTS system mannose fructose sorbose family IID component
C7M45_RS03095	COG0358	DNA primase activity
C7M45_RS03100	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C7M45_RS03110	COG1028	Short-chain dehydrogenase reductase Sdr
C7M45_RS03120	COG0626	cystathionine gamma-synthase activity
C7M45_RS03125	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C7M45_RS03135	COG1126	abc transporter atp-binding protein
C7M45_RS03140	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C7M45_RS03145	COG0436	Aminotransferase
C7M45_RS03155	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C7M45_RS03165	COG0537	adenosine 5'-monophosphoramidase activity
C7M45_RS03170	COG1131	(ABC) transporter
C7M45_RS03180	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C7M45_RS03255	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C7M45_RS03265	COG0018	arginyl-trna synthetase
C7M45_RS03270	COG1438	arginine binding
C7M45_RS03275	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C7M45_RS03280	COG3679	Belongs to the UPF0342 family
C7M45_RS03290	COG0540	Belongs to the ATCase OTCase family
C7M45_RS03295	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C7M45_RS03300	COG0505	Belongs to the CarA family
C7M45_RS03305	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C7M45_RS03310	COG0284	orotidine-5'-phosphate decarboxylase activity
C7M45_RS03315	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C7M45_RS03320	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C7M45_RS03325	COG3763	UPF0154 protein
C7M45_RS03330	COG0204	Acyl-transferase
C7M45_RS03335	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
C7M45_RS03340	COG2827	Endonuclease containing a URI domain
C7M45_RS03345	COG0052	Belongs to the universal ribosomal protein uS2 family
C7M45_RS03350	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C7M45_RS03355	COG0528	UMP kinase activity
C7M45_RS03360	COG0233	cytoplasmic translational termination
C7M45_RS03370	COG0752	glycyl-tRNA synthetase alpha subunit
C7M45_RS03375	COG0751	glycine-tRNA ligase activity
C7M45_RS03380	COG0673	inositol 2-dehydrogenase activity
C7M45_RS03400	COG2264	protein methyltransferase activity
C7M45_RS03405	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C7M45_RS03415	COG0488	(ABC) transporter
C7M45_RS03420	COG3425	synthase
C7M45_RS03435	COG3830	Belongs to the UPF0237 family
C7M45_RS03440	COG2848	UPF0210 protein
C7M45_RS03465	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C7M45_RS03470	COG0134	indole-3-glycerol-phosphate synthase activity
C7M45_RS03480	COG0159	tryptophan synthase activity
C7M45_RS03485	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C7M45_RS03490	COG0512	Glutamine amidotransferase of anthranilate synthase
C7M45_RS03495	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C7M45_RS03505	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
C7M45_RS03510	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C7M45_RS03515	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C7M45_RS03520	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C7M45_RS03525	COG0287	Prephenate dehydrogenase
C7M45_RS03530	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C7M45_RS03540	COG0710	3-dehydroquinate dehydratase activity
C7M45_RS03545	COG0352	thiamine-phosphate diphosphorylase activity
C7M45_RS03550	COG2022	thiamine diphosphate biosynthetic process
C7M45_RS03550	COG2104	thiamine diphosphate biosynthetic process
C7M45_RS03555	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C7M45_RS03560	COG2022	thiamine diphosphate biosynthetic process
C7M45_RS03565	COG2271	Major facilitator Superfamily
C7M45_RS03570	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C7M45_RS03575	COG1028	Short-chain dehydrogenase reductase Sdr
C7M45_RS03585	COG2814	Major facilitator Superfamily
C7M45_RS03600	COG2409	Drug exporters of the RND superfamily
C7M45_RS03605	COG4585	Histidine kinase
C7M45_RS03610	COG2197	response regulator
C7M45_RS03645	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
C7M45_RS03645	COG0131	Imidazoleglycerol-phosphate dehydratase
C7M45_RS03680	COG2826	transposase and inactivated derivatives, IS30 family
C7M45_RS03720	COG2364	Membrane
C7M45_RS03765	COG1192	Involved in chromosome partitioning
C7M45_RS03790	COG0542	response to heat
C7M45_RS03870	COG2814	Major facilitator Superfamily
C7M45_RS03880	COG1511	domain protein
C7M45_RS03885	COG3759	membrane
C7M45_RS03890	COG0604	alcohol dehydrogenase
C7M45_RS03900	COG1846	Transcriptional regulator
C7M45_RS03930	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C7M45_RS03965	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
C7M45_RS03985	COG2801	Transposase and inactivated derivatives
C7M45_RS04030	COG1621	beta-fructofuranosidase activity
C7M45_RS04120	COG2814	Major facilitator Superfamily
C7M45_RS04195	COG2826	transposase and inactivated derivatives, IS30 family
C7M45_RS04205	COG1846	Transcriptional regulator
C7M45_RS04215	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C7M45_RS04225	COG0384	phenazine biosynthesis protein PhzF
C7M45_RS04235	COG3340	Belongs to the peptidase S51 family
C7M45_RS04240	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
C7M45_RS04245	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C7M45_RS04255	COG0702	epimerase
C7M45_RS04260	COG0071	Belongs to the small heat shock protein (HSP20) family
C7M45_RS04265	COG0028	Belongs to the TPP enzyme family
C7M45_RS04280	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C7M45_RS04285	COG2364	Membrane
C7M45_RS04340	COG0300	oxidoreductase activity
C7M45_RS04345	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C7M45_RS04355	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C7M45_RS04360	COG0789	Transcriptional regulator
C7M45_RS04375	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C7M45_RS04380	COG2814	Major facilitator Superfamily
C7M45_RS04385	COG1846	Transcriptional regulator
C7M45_RS04390	COG1316	TRANSCRIPTIONal
C7M45_RS04410	COG5002	protein histidine kinase activity
C7M45_RS04415	COG0745	RESPONSE REGULATOR receiver
C7M45_RS04425	COG3527	Alpha-acetolactate decarboxylase
C7M45_RS04435	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C7M45_RS04440	COG1121	(ABC) transporter
C7M45_RS04445	COG1442	glycosyl transferase family 8
C7M45_RS04465	COG1846	Transcriptional regulator
C7M45_RS04470	COG1733	regulation of RNA biosynthetic process
C7M45_RS04485	COG2723	6-phospho-beta-galactosidase activity
C7M45_RS04505	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
C7M45_RS04515	COG1028	Short-chain dehydrogenase reductase Sdr
C7M45_RS04535	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C7M45_RS04545	COG1447	Phosphotransferase system cellobiose-specific component IIA
C7M45_RS04550	COG3711	transcriptional antiterminator
C7M45_RS04550	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C7M45_RS04560	COG2723	6-phospho-beta-galactosidase activity
C7M45_RS04570	COG1619	proteins homologs of microcin C7 resistance protein MccF
C7M45_RS04575	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
C7M45_RS04580	COG2610	gluconate transmembrane transporter activity
C7M45_RS04585	COG1028	Short-chain dehydrogenase reductase Sdr
C7M45_RS04590	COG0436	Aminotransferase
C7M45_RS04600	COG0693	protein deglycase activity
C7M45_RS04615	COG4720	Psort location CytoplasmicMembrane, score
C7M45_RS04620	COG1573	uracil-dna glycosylase
C7M45_RS04625	COG1129	ABC transporter
C7M45_RS04635	COG1063	alcohol dehydrogenase
C7M45_RS04640	COG0477	Major facilitator Superfamily
C7M45_RS04650	COG0300	oxidoreductase activity
C7M45_RS04665	COG1215	transferase activity, transferring glycosyl groups
C7M45_RS04700	COG2244	polysaccharide biosynthetic process
C7M45_RS04705	COG1956	GAF domain-containing protein
C7M45_RS04715	COG2723	6-phospho-beta-galactosidase activity
C7M45_RS04725	COG3711	transcriptional antiterminator
C7M45_RS04750	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C7M45_RS04765	COG1609	Transcriptional regulator
C7M45_RS04790	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C7M45_RS04795	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
C7M45_RS04800	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
C7M45_RS04810	COG1609	Transcriptional regulator
C7M45_RS04815	COG2190	(PTS) system
C7M45_RS04815	COG2211	Major facilitator Superfamily
C7M45_RS04845	COG5039	Polysaccharide pyruvyl transferase
C7M45_RS04850	COG2814	Major facilitator Superfamily
C7M45_RS04860	COG2261	transglycosylase associated protein
C7M45_RS04885	COG2261	transglycosylase associated protein
C7M45_RS04900	COG1028	Short-chain dehydrogenase reductase Sdr
C7M45_RS04920	COG2160	L-arabinose isomerase activity
C7M45_RS04925	COG1609	Transcriptional regulator
C7M45_RS04940	COG0789	Transcriptional regulator
C7M45_RS04970	COG1874	Beta-galactosidase
C7M45_RS04980	COG1051	belongs to the nudix hydrolase family
C7M45_RS04985	COG0667	Aldo Keto reductase
C7M45_RS04995	COG1045	serine acetyltransferase
C7M45_RS05000	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C7M45_RS05005	COG0583	DNA-binding transcription factor activity
C7M45_RS05015	COG1136	(ABC) transporter
C7M45_RS05020	COG5002	protein histidine kinase activity
C7M45_RS05025	COG0745	RESPONSE REGULATOR receiver
C7M45_RS05030	COG0693	protein deglycase activity
C7M45_RS05050	COG1609	Transcriptional regulator
C7M45_RS05060	COG2814	Major facilitator Superfamily
C7M45_RS05065	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C7M45_RS05070	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C7M45_RS05080	COG0307	riboflavin synthase, alpha
C7M45_RS05085	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C7M45_RS05085	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C7M45_RS05100	COG0493	'glutamate synthase
C7M45_RS05120	COG1033	growth of symbiont in host cell
C7M45_RS05120	COG2409	Drug exporters of the RND superfamily
C7M45_RS05135	COG0577	efflux transmembrane transporter activity
C7M45_RS05145	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C7M45_RS05165	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C7M45_RS05170	COG1121	(ABC) transporter
C7M45_RS05185	COG2877	3-deoxy-8-phosphooctulonate synthase activity
C7M45_RS05190	COG0517	IMP dehydrogenase activity
C7M45_RS05190	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
C7M45_RS05210	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C7M45_RS05215	COG1609	Transcriptional regulator
C7M45_RS05240	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C7M45_RS05245	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C7M45_RS05250	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C7M45_RS05255	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C7M45_RS05260	COG0460	homoserine dehydrogenase
C7M45_RS05265	COG0083	homoserine kinase activity
C7M45_RS05270	COG0527	aspartate kinase activity
C7M45_RS05280	COG0252	asparaginase activity
C7M45_RS05285	COG1381	Involved in DNA repair and RecF pathway recombination
C7M45_RS05290	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C7M45_RS05300	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C7M45_RS05305	COG1702	phosphate starvation-inducible protein PhoH
C7M45_RS05310	COG0004	ammonium transporteR
C7M45_RS05320	COG0587	DNA-directed DNA polymerase activity
C7M45_RS05335	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C7M45_RS05340	COG2384	SAM-dependent methyltransferase
C7M45_RS05355	COG1122	ATPase activity
C7M45_RS05365	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C7M45_RS05370	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
C7M45_RS05375	COG4479	Belongs to the UPF0346 family
C7M45_RS05385	COG2755	lipolytic protein G-D-S-L family
C7M45_RS05395	COG1957	nucleoside hydrolase
C7M45_RS05400	COG1307	EDD domain protein, DegV family
C7M45_RS05410	COG0617	tRNA 3'-terminal CCA addition
C7M45_RS05430	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
C7M45_RS05435	COG1169	isochorismate synthase
C7M45_RS05440	COG0351	phosphomethylpyrimidine kinase
C7M45_RS05450	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C7M45_RS05455	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C7M45_RS05475	COG0584	glycerophosphoryl diester phosphodiesterase
C7M45_RS05480	COG2267	carboxylic ester hydrolase activity
C7M45_RS05490	COG0508	dehydrogenase complex catalyzes the overall conversion of
C7M45_RS05505	COG0095	Lipoate-protein ligase
C7M45_RS05515	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C7M45_RS05535	COG4717	serine-type aminopeptidase activity
C7M45_RS05540	COG0420	3'-5' exonuclease activity
C7M45_RS05545	COG0138	bifunctional purine biosynthesis protein purh
C7M45_RS05550	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C7M45_RS05555	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C7M45_RS05565	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C7M45_RS05575	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C7M45_RS05580	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C7M45_RS05585	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
C7M45_RS05590	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
C7M45_RS05595	COG0174	glutamine synthetase
C7M45_RS05600	COG0789	Transcriptional regulator
C7M45_RS05610	COG3764	Sortase (surface protein transpeptidase)
C7M45_RS05615	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C7M45_RS05615	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C7M45_RS05620	COG1621	beta-fructofuranosidase activity
C7M45_RS05620	COG3583	domain protein
C7M45_RS05620	COG5492	domain, Protein
C7M45_RS05635	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C7M45_RS05645	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C7M45_RS05650	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C7M45_RS05660	COG0494	nUDIX hydrolase
C7M45_RS05665	COG1278	Cold shock
C7M45_RS05670	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
C7M45_RS05675	COG2759	Belongs to the formate--tetrahydrofolate ligase family
C7M45_RS05680	COG0151	Belongs to the GarS family
C7M45_RS05685	COG0667	Aldo Keto reductase
C7M45_RS05695	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C7M45_RS05700	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C7M45_RS05715	COG1744	ABC transporter substrate-binding protein PnrA-like
C7M45_RS05720	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C7M45_RS05720	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
C7M45_RS05735	COG2176	DNA-directed DNA polymerase activity
C7M45_RS05740	COG0442	prolyl-tRNA aminoacylation
C7M45_RS05745	COG0750	zinc metalloprotease
C7M45_RS05750	COG4589	Belongs to the CDS family
C7M45_RS05755	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C7M45_RS05760	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C7M45_RS05765	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
C7M45_RS05775	COG2239	Acts as a magnesium transporter
C7M45_RS05780	COG0564	pseudouridine synthase activity
C7M45_RS05785	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C7M45_RS05790	COG2357	RelA SpoT domain protein
C7M45_RS05800	COG1940	carbohydrate kinase activity
C7M45_RS05810	COG0705	Rhomboid family
C7M45_RS05815	COG3557	Belongs to the UPF0374 family
C7M45_RS05820	COG2137	regulation of response to DNA damage stimulus
C7M45_RS05825	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C7M45_RS05830	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C7M45_RS05835	COG1473	amidohydrolase
C7M45_RS05840	COG2171	N-acyltransferase activity
C7M45_RS05860	COG0586	Pfam SNARE associated Golgi protein
C7M45_RS05865	COG1113	amino acid transport
C7M45_RS05870	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C7M45_RS05875	COG1280	lysine exporter protein (LysE YggA)
C7M45_RS05875	COG1674	ftsk spoiiie
C7M45_RS05890	COG0628	permease
C7M45_RS05895	COG2706	6-phosphogluconolactonase activity
C7M45_RS05900	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C7M45_RS05910	COG3599	regulation of cell shape
C7M45_RS05915	COG4474	Belongs to the UPF0398 family
C7M45_RS05925	COG3331	DNA recombination
C7M45_RS05940	COG0517	IMP dehydrogenase activity
C7M45_RS05940	COG0516	GMP reductase activity
C7M45_RS05950	COG3237	CsbD-like
C7M45_RS05960	COG1942	4-Oxalocrotonate Tautomerase
C7M45_RS05965	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C7M45_RS05970	COG0501	Belongs to the peptidase M48B family
C7M45_RS05975	COG1704	LemA family
C7M45_RS05990	COG2244	polysaccharide biosynthetic process
C7M45_RS05995	COG0495	leucyl-tRNA aminoacylation
C7M45_RS06000	COG0671	phosphoesterase, PA-phosphatase related
C7M45_RS06010	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C7M45_RS06020	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
C7M45_RS06025	COG1126	abc transporter atp-binding protein
C7M45_RS06030	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C7M45_RS06050	COG4684	Psort location CytoplasmicMembrane, score
C7M45_RS06060	COG4684	Psort location CytoplasmicMembrane, score
C7M45_RS06065	COG1136	(ABC) transporter
C7M45_RS06070	COG0577	efflux transmembrane transporter activity
C7M45_RS06075	COG1970	mechanosensitive ion channel activity
C7M45_RS06080	COG1428	Deoxynucleoside kinase
C7M45_RS06085	COG0632	four-way junction helicase activity
C7M45_RS06090	COG0584	glycerophosphoryl diester phosphodiesterase
C7M45_RS06095	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
C7M45_RS06105	COG2255	four-way junction helicase activity
C7M45_RS06115	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C7M45_RS06120	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C7M45_RS06125	COG1719	4-vinyl reductase, 4VR
C7M45_RS06130	COG0335	large ribosomal subunit rRNA binding
C7M45_RS06135	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C7M45_RS06145	COG1609	Transcriptional regulator
C7M45_RS06150	COG1063	alcohol dehydrogenase
C7M45_RS06165	COG0492	ferredoxin-NADP+ reductase activity
C7M45_RS06170	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C7M45_RS06175	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C7M45_RS06180	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
C7M45_RS06185	COG1950	PFAM Membrane protein of
C7M45_RS06195	COG0704	Plays a role in the regulation of phosphate uptake
C7M45_RS06200	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C7M45_RS06205	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C7M45_RS06210	COG0581	inorganic phosphate transmembrane transporter activity
C7M45_RS06215	COG0573	inorganic phosphate transmembrane transporter activity
C7M45_RS06220	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C7M45_RS06230	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C7M45_RS06235	COG0745	RESPONSE REGULATOR receiver
C7M45_RS06240	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C7M45_RS06245	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C7M45_RS06250	COG1426	Protein conserved in bacteria
C7M45_RS06255	COG0612	Peptidase, M16
C7M45_RS06260	COG0612	Peptidase, M16
C7M45_RS06280	COG0765	amino acid transport
C7M45_RS06290	COG1792	Involved in formation and maintenance of cell shape
C7M45_RS06295	COG1077	Cell shape determining protein MreB Mrl
C7M45_RS06300	COG0542	response to heat
C7M45_RS06315	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C7M45_RS06330	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C7M45_RS06335	COG1705	Flagellar rod assembly protein muramidase FlgJ
C7M45_RS06340	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
C7M45_RS06345	COG4988	ABC transporter
C7M45_RS06350	COG1294	oxidase, subunit
C7M45_RS06355	COG1271	oxidase subunit
C7M45_RS06360	COG3906	Belongs to the UPF0473 family
C7M45_RS06365	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C7M45_RS06370	COG4472	Bacterial protein of unknown function (DUF965)
C7M45_RS06375	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C7M45_RS06385	COG0531	amino acid
C7M45_RS06400	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
C7M45_RS06405	COG1737	Transcriptional regulator
C7M45_RS06410	COG3527	Alpha-acetolactate decarboxylase
C7M45_RS06425	COG2814	Major facilitator Superfamily
C7M45_RS06435	COG1609	Transcriptional regulator
C7M45_RS06455	COG0561	phosphatase activity
C7M45_RS06460	COG3091	SprT-like family
C7M45_RS06465	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C7M45_RS06470	COG0416	fatty acid biosynthetic process
C7M45_RS06475	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C7M45_RS06500	COG1484	DNA-dependent DNA replication
C7M45_RS06510	COG0237	dephospho-CoA kinase activity
C7M45_RS06520	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C7M45_RS06525	COG0513	Belongs to the DEAD box helicase family
C7M45_RS06530	COG0673	inositol 2-dehydrogenase activity
C7M45_RS06540	COG2309	aminopeptidase activity
C7M45_RS06545	COG0028	Belongs to the TPP enzyme family
C7M45_RS06550	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C7M45_RS06555	COG0322	excinuclease ABC activity
C7M45_RS06560	COG0504	CTP synthase activity
C7M45_RS06565	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
C7M45_RS06565	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
C7M45_RS06575	COG1268	BioY protein
C7M45_RS06580	COG1113	amino acid transport
C7M45_RS06590	COG3343	RNA polymerase activity
C7M45_RS06600	COG1078	dGTPase activity
C7M45_RS06605	COG2188	Transcriptional regulator
C7M45_RS06610	COG0366	Alpha amylase catalytic
C7M45_RS06615	COG2190	(PTS) system
C7M45_RS06615	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C7M45_RS06615	COG1263	PTS System
C7M45_RS06625	COG2936	dipeptidyl-peptidase activity
C7M45_RS06635	COG0308	aminopeptidase N
C7M45_RS06645	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C7M45_RS06665	COG1609	Transcriptional regulator
C7M45_RS06670	COG0025	NhaP-type Na H and K H
C7M45_RS06675	COG4493	Belongs to the UPF0637 family
C7M45_RS06715	COG1012	belongs to the aldehyde dehydrogenase family
C7M45_RS06720	COG0352	thiamine-phosphate diphosphorylase activity
C7M45_RS06725	COG0351	phosphomethylpyrimidine kinase
C7M45_RS06730	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
C7M45_RS06735	COG0410	ABC transporter
C7M45_RS06740	COG0411	ABC transporter
C7M45_RS06750	COG0559	Belongs to the binding-protein-dependent transport system permease family
C7M45_RS06755	COG0683	leucine binding
C7M45_RS06790	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C7M45_RS06795	COG4975	Glucose uptake
C7M45_RS06805	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C7M45_RS06835	COG4537	Required for transformation and DNA binding
C7M45_RS06845	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C7M45_RS06850	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C7M45_RS06855	COG2131	deaminase
C7M45_RS06860	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
C7M45_RS06865	COG2003	Belongs to the UPF0758 family
C7M45_RS06870	COG2814	Major facilitator Superfamily
C7M45_RS06890	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C7M45_RS06895	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C7M45_RS06900	COG0254	rRNA binding
C7M45_RS06905	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C7M45_RS06910	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C7M45_RS06910	COG0072	phenylalanine-tRNA ligase activity
C7M45_RS06915	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C7M45_RS06920	COG1733	regulation of RNA biosynthetic process
C7M45_RS06950	COG0765	amino acid transport
C7M45_RS06955	COG1126	abc transporter atp-binding protein
C7M45_RS06960	COG0765	amino acid transport
C7M45_RS06965	COG1744	ABC transporter substrate-binding protein PnrA-like
C7M45_RS07000	COG1464	Belongs to the NlpA lipoprotein family
C7M45_RS07005	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C7M45_RS07010	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C7M45_RS07030	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
C7M45_RS07075	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C7M45_RS07080	COG2252	PERMEase
C7M45_RS07095	COG0217	transcriptional regulatory protein
C7M45_RS07120	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C7M45_RS07125	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
C7M45_RS07130	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C7M45_RS07140	COG0037	tRNA processing
C7M45_RS07150	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
C7M45_RS07155	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C7M45_RS07160	COG0193	aminoacyl-tRNA hydrolase activity
C7M45_RS07170	COG0740	serine-type endopeptidase activity
C7M45_RS07175	COG1481	regulation of sporulation
C7M45_RS07180	COG0391	Required for morphogenesis under gluconeogenic growth conditions
C7M45_RS07185	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C7M45_RS07190	COG0556	nucleotide-excision repair
C7M45_RS07195	COG1368	sulfuric ester hydrolase activity
C7M45_RS07215	COG0438	transferase activity, transferring glycosyl groups
C7M45_RS07220	COG1132	(ABC) transporter
C7M45_RS07225	COG1132	(ABC) transporter
C7M45_RS07240	COG0406	alpha-ribazole phosphatase activity
C7M45_RS07255	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
C7M45_RS07255	COG0392	lysyltransferase activity
C7M45_RS07265	COG1862	Preprotein translocase
C7M45_RS07270	COG0343	queuine tRNA-ribosyltransferase activity
C7M45_RS07275	COG2814	Major facilitator Superfamily
C7M45_RS07280	COG1126	abc transporter atp-binding protein
C7M45_RS07285	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C7M45_RS07290	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C7M45_RS07295	COG1126	abc transporter atp-binding protein
C7M45_RS07300	COG0765	amino acid transport
C7M45_RS07305	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C7M45_RS07310	COG0765	amino acid transport
C7M45_RS07345	COG4152	abc transporter atp-binding protein
C7M45_RS07365	COG4175	Glycine betaine
C7M45_RS07365	COG3448	diguanylate cyclase activity
C7M45_RS07375	COG0166	Belongs to the GPI family
C7M45_RS07380	COG0363	glucosamine-6-phosphate deaminase activity
C7M45_RS07390	COG2205	protein histidine kinase activity
C7M45_RS07395	COG0745	RESPONSE REGULATOR receiver
C7M45_RS07405	COG0012	GTP binding
C7M45_RS07410	COG4481	Protein conserved in bacteria
C7M45_RS07415	COG1475	DNA binding
C7M45_RS07420	COG1192	Involved in chromosome partitioning
C7M45_RS07425	COG0357	Ribosomal RNA small subunit methyltransferase G
C7M45_RS07430	COG1957	nucleoside hydrolase
C7M45_RS07445	COG0640	Transcriptional regulator
C7M45_RS07455	COG1914	H( )-stimulated, divalent metal cation uptake system
C7M45_RS07465	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C7M45_RS07490	COG1316	TRANSCRIPTIONal
C7M45_RS07495	COG1136	(ABC) transporter
C7M45_RS07495	COG0577	efflux transmembrane transporter activity
C7M45_RS07505	COG0640	Transcriptional regulator
C7M45_RS07520	COG3103	Sh3 type 3 domain protein
C7M45_RS07520	COG1388	LysM domain
C7M45_RS07520	COG0791	NLP P60 protein
C7M45_RS07535	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C7M45_RS07540	COG0525	valine-tRNA ligase activity
C7M45_RS07560	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
C7M45_RS07565	COG0439	Biotin carboxylase
C7M45_RS07575	COG0511	ligase activity, forming carbon-carbon bonds
C7M45_RS07580	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C7M45_RS07585	COG1028	Short-chain dehydrogenase reductase Sdr
C7M45_RS07590	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C7M45_RS07600	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C7M45_RS07605	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C7M45_RS07615	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C7M45_RS07635	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C7M45_RS07645	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
C7M45_RS07645	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
C7M45_RS07650	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C7M45_RS07650	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C7M45_RS07655	COG1418	mRNA catabolic process
C7M45_RS07665	COG0492	ferredoxin-NADP+ reductase activity
C7M45_RS07675	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C7M45_RS07680	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
C7M45_RS07685	COG1428	Deoxynucleoside kinase
C7M45_RS07700	COG1940	carbohydrate kinase activity
C7M45_RS07705	COG1621	beta-fructofuranosidase activity
C7M45_RS07715	COG1609	Transcriptional regulator
C7M45_RS07730	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C7M45_RS07745	COG0470	DNA polymerase III
C7M45_RS07750	COG3870	Protein conserved in bacteria
C7M45_RS07755	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C7M45_RS07765	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C7M45_RS07770	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C7M45_RS07785	COG0590	tRNA wobble adenosine to inosine editing
C7M45_RS07790	COG2813	Specifically methylates the guanine in position
C7M45_RS07795	COG0222	ribosome binding
C7M45_RS07800	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C7M45_RS07805	COG0081	regulation of translation
C7M45_RS07810	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C7M45_RS07815	COG0250	Participates in transcription elongation, termination and antitermination
C7M45_RS07825	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C7M45_RS07835	COG1181	Belongs to the D-alanine--D-alanine ligase family
C7M45_RS07845	COG0772	Belongs to the SEDS family
C7M45_RS07855	COG1077	Cell shape determining protein MreB Mrl
C7M45_RS07870	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C7M45_RS07885	COG1780	Probably involved in ribonucleotide reductase function
C7M45_RS07890	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C7M45_RS07895	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
C7M45_RS07900	COG1253	flavin adenine dinucleotide binding
C7M45_RS07905	COG0588	phosphoglycerate mutase activity
C7M45_RS07920	COG1040	competence protein
C7M45_RS07925	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
C7M45_RS07930	COG1739	Uncharacterized protein family UPF0029
C7M45_RS07940	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
C7M45_RS07950	COG0519	Catalyzes the synthesis of GMP from XMP
C7M45_RS07955	COG0148	phosphopyruvate hydratase activity
C7M45_RS07960	COG0149	triose-phosphate isomerase activity
C7M45_RS07990	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C7M45_RS07995	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C7M45_RS08005	COG0101	tRNA pseudouridine synthase activity
C7M45_RS08010	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
C7M45_RS08015	COG1122	ATPase activity
C7M45_RS08020	COG1122	ATPase activity
C7M45_RS08030	COG0142	geranyltranstransferase activity
C7M45_RS08035	COG0203	ribosomal protein L17
C7M45_RS08040	COG0202	RNA polymerase activity
C7M45_RS08045	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C7M45_RS08050	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C7M45_RS08055	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C7M45_RS08060	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C7M45_RS08065	COG0563	adenylate kinase activity
C7M45_RS08075	COG0200	Binds to the 23S rRNA
C7M45_RS08080	COG1841	ribosomal large subunit assembly
C7M45_RS08085	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C7M45_RS08090	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C7M45_RS08095	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C7M45_RS08100	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C7M45_RS08105	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C7M45_RS08110	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
C7M45_RS08115	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C7M45_RS08120	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C7M45_RS08125	COG0255	Belongs to the universal ribosomal protein uL29 family
C7M45_RS08130	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C7M45_RS08135	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C7M45_RS08140	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C7M45_RS08145	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C7M45_RS08150	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C7M45_RS08155	COG0089	rRNA binding
C7M45_RS08160	COG0088	Forms part of the polypeptide exit tunnel
C7M45_RS08165	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C7M45_RS08170	COG0051	transcription antitermination factor activity, RNA binding
C7M45_RS08175	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
C7M45_RS08180	COG1177	transmembrane transport
C7M45_RS08185	COG1177	transmembrane transport
C7M45_RS08190	COG3842	ATPase activity
C7M45_RS08195	COG2807	transmembrane transport
C7M45_RS08200	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C7M45_RS08205	COG0049	tRNA binding
C7M45_RS08210	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C7M45_RS08220	COG0542	response to heat
C7M45_RS08225	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
C7M45_RS08230	COG0653	protein targeting
C7M45_RS08235	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C7M45_RS08335	COG0215	cysteine-tRNA ligase activity
C7M45_RS08340	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C7M45_RS08345	COG1309	transcriptional regulator
C7M45_RS08360	COG0756	dUTP diphosphatase activity
C7M45_RS08370	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
C7M45_RS08405	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C7M45_RS08410	COG1012	belongs to the aldehyde dehydrogenase family
C7M45_RS08410	COG1454	alcohol dehydrogenase
C7M45_RS08425	COG0351	phosphomethylpyrimidine kinase
C7M45_RS08430	COG4720	Psort location CytoplasmicMembrane, score
C7M45_RS08440	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
C7M45_RS08445	COG1126	abc transporter atp-binding protein
C7M45_RS08455	COG0765	amino acid transport
C7M45_RS08460	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C7M45_RS08475	COG1968	undecaprenyl-diphosphatase activity
C7M45_RS08490	COG2115	Belongs to the xylose isomerase family
C7M45_RS08505	COG1272	protein, Hemolysin III
C7M45_RS08510	COG1307	EDD domain protein, DegV family
C7M45_RS08515	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C7M45_RS08520	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C7M45_RS08530	COG1464	Belongs to the NlpA lipoprotein family
C7M45_RS08540	COG0531	amino acid
C7M45_RS08545	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
C7M45_RS08550	COG3118	belongs to the thioredoxin family
C7M45_RS08555	COG1473	amidohydrolase
C7M45_RS08560	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C7M45_RS08565	COG1126	abc transporter atp-binding protein
C7M45_RS08570	COG0765	amino acid transport
C7M45_RS08595	COG0446	pyridine nucleotide-disulphide oxidoreductase
C7M45_RS08605	COG0463	Glycosyl transferase, family 2
C7M45_RS08610	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
C7M45_RS08620	COG1131	(ABC) transporter
C7M45_RS08625	COG1053	succinate dehydrogenase
C7M45_RS08635	COG0351	phosphomethylpyrimidine kinase
C7M45_RS08700	COG1028	Short-chain dehydrogenase reductase Sdr
C7M45_RS08705	COG1396	sequence-specific DNA binding
C7M45_RS08715	COG4120	Belongs to the binding-protein-dependent transport system permease family
C7M45_RS08775	COG2271	Major facilitator Superfamily
C7M45_RS08780	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C7M45_RS08785	COG0569	domain protein
C7M45_RS08800	COG1881	PFAM PEBP family protein
C7M45_RS08805	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C7M45_RS08810	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
C7M45_RS08815	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C7M45_RS08820	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C7M45_RS08830	COG0656	L-ascorbic acid biosynthetic process
C7M45_RS08850	COG1131	(ABC) transporter
C7M45_RS08855	COG1725	Transcriptional regulator
C7M45_RS08865	COG2217	Heavy metal translocating P-type atpase
C7M45_RS08870	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C7M45_RS08875	COG0564	pseudouridine synthase activity
C7M45_RS08885	COG0438	transferase activity, transferring glycosyl groups
C7M45_RS08890	COG1368	sulfuric ester hydrolase activity
C7M45_RS08895	COG2153	protein acetylation
C7M45_RS08910	COG0647	UMP catabolic process
C7M45_RS08915	COG2814	Major facilitator Superfamily
C7M45_RS09015	COG0436	Aminotransferase
C7M45_RS09020	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C7M45_RS09025	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
C7M45_RS09040	COG1073	alpha beta
C7M45_RS09070	COG0386	Belongs to the glutathione peroxidase family
C7M45_RS09080	COG0187	DNA topoisomerase II activity
C7M45_RS09085	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C7M45_RS09095	COG0592	DNA-directed DNA polymerase activity
C7M45_RS09100	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C7M45_RS09120	COG0561	phosphatase activity
C7M45_RS09125	COG2084	Dehydrogenase
C7M45_RS09135	COG0446	pyridine nucleotide-disulphide oxidoreductase
C7M45_RS09140	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C7M45_RS09145	COG0230	Belongs to the bacterial ribosomal protein bL34 family
C7M45_RS09150	COG0594	ribonuclease P activity
C7M45_RS09155	COG0706	membrane insertase activity
C7M45_RS09175	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C7M45_RS09180	COG0583	DNA-binding transcription factor activity
C7M45_RS09185	COG2855	membrane
C7M45_RS09215	COG0577	efflux transmembrane transporter activity
C7M45_RS09215	COG1136	(ABC) transporter
C7M45_RS09220	COG0577	efflux transmembrane transporter activity
C7M45_RS09235	COG1983	PspC domain protein
C7M45_RS09250	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C7M45_RS09265	COG2151	metal-sulfur cluster biosynthetic enzyme
C7M45_RS09270	COG0129	dihydroxy-acid dehydratase activity
C7M45_RS09280	COG0396	ATPase activity
C7M45_RS09285	COG0719	Fe-S assembly protein
C7M45_RS09290	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C7M45_RS09300	COG0719	Fe-S assembly protein
C7M45_RS09305	COG2151	metal-sulfur cluster biosynthetic enzyme
C7M45_RS09315	COG0473	3-isopropylmalate dehydrogenase activity
C7M45_RS09320	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C7M45_RS09325	COG0066	3-isopropylmalate dehydratase activity
C7M45_RS09330	COG2814	Major facilitator Superfamily
C7M45_RS09355	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
C7M45_RS09365	COG0318	PFAM AMP-dependent synthetase and ligase
C7M45_RS09370	COG2226	methyltransferase
C7M45_RS09375	COG0803	Belongs to the bacterial solute-binding protein 9 family
C7M45_RS09385	COG1686	Belongs to the peptidase S11 family
C7M45_RS09395	COG2814	Major facilitator Superfamily
C7M45_RS09405	COG0667	Aldo Keto reductase
C7M45_RS09415	COG0667	Aldo Keto reductase
C7M45_RS09420	COG1733	regulation of RNA biosynthetic process
C7M45_RS09425	COG1902	pentaerythritol trinitrate reductase activity
C7M45_RS09440	COG1113	amino acid transport
C7M45_RS09445	COG0583	DNA-binding transcription factor activity
C7M45_RS09455	COG2814	Major facilitator Superfamily
C7M45_RS09480	COG0561	phosphatase activity
C7M45_RS09515	COG3623	hexulose-6-phosphate isomerase
C7M45_RS09520	COG0235	Class ii aldolase
C7M45_RS09580	COG0514	ATP-dependent DNA helicase (RecQ)
C7M45_RS09590	COG4720	Psort location CytoplasmicMembrane, score
C7M45_RS09595	COG1122	ATPase activity
C7M45_RS09605	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C7M45_RS09610	COG0360	Binds together with S18 to 16S ribosomal RNA
C7M45_RS09615	COG0629	single-stranded DNA binding
C7M45_RS09620	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C7M45_RS09630	COG0359	binds to the 23S rRNA
C7M45_RS09635	COG0305	Participates in initiation and elongation during chromosome replication
C7M45_RS09645	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C7M45_RS09650	COG2188	Transcriptional regulator
C7M45_RS09655	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
C7M45_RS09660	COG1119	ATPase activity
C7M45_RS09665	COG0028	Belongs to the TPP enzyme family
C7M45_RS09675	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
C7M45_RS09680	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C7M45_RS09690	COG0473	3-isopropylmalate dehydrogenase activity
C7M45_RS09705	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C7M45_RS09710	COG0745	RESPONSE REGULATOR receiver
C7M45_RS09730	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C7M45_RS09735	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
C7M45_RS09740	COG1511	domain protein
C7M45_RS09745	COG1959	2 iron, 2 sulfur cluster binding
C7M45_RS09750	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C7M45_RS09755	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C7M45_RS09760	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C7M45_RS09770	COG1132	(ABC) transporter
C7M45_RS09775	COG1132	(ABC) transporter
C7M45_RS09780	COG1126	abc transporter atp-binding protein
C7M45_RS09785	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C7M45_RS09790	COG0765	amino acid transport
C7M45_RS09795	COG0765	amino acid transport
C7M45_RS09800	COG4166	transmembrane transport
C7M45_RS09805	COG0601	transmembrane transport
C7M45_RS09810	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C7M45_RS09815	COG0444	Belongs to the ABC transporter superfamily
C7M45_RS09820	COG4608	Belongs to the ABC transporter superfamily
C7M45_RS09825	COG3590	peptidase
C7M45_RS09855	COG0126	phosphoglycerate kinase activity
C7M45_RS09860	COG2814	Major facilitator Superfamily
C7M45_RS09865	COG1064	alcohol dehydrogenase
C7M45_RS09885	COG0488	(ABC) transporter
C7M45_RS09975	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C7M45_RS10015	COG3118	belongs to the thioredoxin family
C7M45_RS10020	COG0446	pyridine nucleotide-disulphide oxidoreductase
C7M45_RS10025	COG1937	Protein conserved in bacteria
C7M45_RS10050	COG0783	Belongs to the Dps family
C7M45_RS10055	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C7M45_RS10085	COG0390	transport system, permease component
C7M45_RS10090	COG4619	ABC transporter
C7M45_RS10100	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C7M45_RS10190	COG1192	Involved in chromosome partitioning
C7M45_RS10200	COG1573	uracil-dna glycosylase
C7M45_RS10205	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C7M45_RS10210	COG2801	Transposase and inactivated derivatives
C7M45_RS10225	COG3118	belongs to the thioredoxin family
C7M45_RS10245	COG0492	ferredoxin-NADP+ reductase activity
C7M45_RS10250	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C7M45_RS10255	COG3118	belongs to the thioredoxin family
C7M45_RS10400	COG2217	Heavy metal translocating P-type atpase
C7M45_RS10440	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C7M45_RS10445	COG1959	2 iron, 2 sulfur cluster binding
C7M45_RS10450	COG0604	alcohol dehydrogenase
C7M45_RS10470	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C7M45_RS10480	COG0492	ferredoxin-NADP+ reductase activity
C7M45_RS10490	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C7M45_RS10495	COG3118	belongs to the thioredoxin family