locus-tag	class	description
A6B45_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
A6B45_RS00010	COG0592	DNA-directed DNA polymerase activity
A6B45_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
A6B45_RS00025	COG0187	DNA topoisomerase II activity
A6B45_RS00035	COG0386	Belongs to the glutathione peroxidase family
A6B45_RS00065	COG1073	alpha beta
A6B45_RS00080	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
A6B45_RS00085	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A6B45_RS00090	COG0436	Aminotransferase
A6B45_RS00190	COG2814	Major facilitator Superfamily
A6B45_RS00195	COG0647	UMP catabolic process
A6B45_RS00215	COG1368	sulfuric ester hydrolase activity
A6B45_RS00220	COG0438	transferase activity, transferring glycosyl groups
A6B45_RS00230	COG0564	pseudouridine synthase activity
A6B45_RS00235	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A6B45_RS00240	COG2217	Heavy metal translocating P-type atpase
A6B45_RS00250	COG1725	Transcriptional regulator
A6B45_RS00255	COG1131	(ABC) transporter
A6B45_RS00265	COG1131	(ABC) transporter
A6B45_RS00275	COG0656	L-ascorbic acid biosynthetic process
A6B45_RS00285	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A6B45_RS00290	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
A6B45_RS00295	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
A6B45_RS00300	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
A6B45_RS00305	COG1881	PFAM PEBP family protein
A6B45_RS00320	COG0569	domain protein
A6B45_RS00325	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A6B45_RS00330	COG2271	Major facilitator Superfamily
A6B45_RS00355	COG3845	ABC transporter
A6B45_RS00360	COG4603	Belongs to the binding-protein-dependent transport system permease family
A6B45_RS00365	COG1079	Belongs to the binding-protein-dependent transport system permease family
A6B45_RS00380	COG4120	Belongs to the binding-protein-dependent transport system permease family
A6B45_RS00390	COG1396	sequence-specific DNA binding
A6B45_RS00395	COG1028	Short-chain dehydrogenase reductase Sdr
A6B45_RS00480	COG1053	succinate dehydrogenase
A6B45_RS00485	COG1131	(ABC) transporter
A6B45_RS00495	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
A6B45_RS00500	COG0463	Glycosyl transferase, family 2
A6B45_RS00510	COG0446	pyridine nucleotide-disulphide oxidoreductase
A6B45_RS00525	COG1464	Belongs to the NlpA lipoprotein family
A6B45_RS00535	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
A6B45_RS00540	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
A6B45_RS00545	COG1307	EDD domain protein, DegV family
A6B45_RS00550	COG1272	protein, Hemolysin III
A6B45_RS00570	COG2115	Belongs to the xylose isomerase family
A6B45_RS00585	COG1968	undecaprenyl-diphosphatase activity
A6B45_RS00600	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6B45_RS00605	COG0765	amino acid transport
A6B45_RS00610	COG0765	amino acid transport
A6B45_RS00615	COG1126	abc transporter atp-binding protein
A6B45_RS00620	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
A6B45_RS00630	COG4720	Psort location CytoplasmicMembrane, score
A6B45_RS00635	COG0351	phosphomethylpyrimidine kinase
A6B45_RS00650	COG1012	belongs to the aldehyde dehydrogenase family
A6B45_RS00650	COG1454	alcohol dehydrogenase
A6B45_RS00655	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A6B45_RS00690	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
A6B45_RS00700	COG0756	dUTP diphosphatase activity
A6B45_RS00720	COG1309	transcriptional regulator
A6B45_RS00725	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A6B45_RS00730	COG0215	cysteine-tRNA ligase activity
A6B45_RS00830	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
A6B45_RS00835	COG0653	protein targeting
A6B45_RS00840	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
A6B45_RS00845	COG0542	response to heat
A6B45_RS00850	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
A6B45_RS00855	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
A6B45_RS00860	COG0049	tRNA binding
A6B45_RS00865	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A6B45_RS00870	COG2807	transmembrane transport
A6B45_RS00875	COG3842	ATPase activity
A6B45_RS00880	COG1177	transmembrane transport
A6B45_RS00885	COG1177	transmembrane transport
A6B45_RS00890	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
A6B45_RS00895	COG0051	transcription antitermination factor activity, RNA binding
A6B45_RS00900	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
A6B45_RS00905	COG0088	Forms part of the polypeptide exit tunnel
A6B45_RS00910	COG0089	rRNA binding
A6B45_RS00915	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
A6B45_RS00920	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
A6B45_RS00925	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
A6B45_RS00930	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
A6B45_RS00935	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
A6B45_RS00940	COG0255	Belongs to the universal ribosomal protein uL29 family
A6B45_RS00945	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
A6B45_RS00950	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
A6B45_RS00955	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
A6B45_RS00960	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
A6B45_RS00965	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
A6B45_RS00970	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
A6B45_RS00975	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
A6B45_RS00980	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
A6B45_RS00985	COG1841	ribosomal large subunit assembly
A6B45_RS00990	COG0200	Binds to the 23S rRNA
A6B45_RS01000	COG0563	adenylate kinase activity
A6B45_RS01005	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
A6B45_RS01010	COG0257	Belongs to the bacterial ribosomal protein bL36 family
A6B45_RS01015	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
A6B45_RS01020	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
A6B45_RS01025	COG0202	RNA polymerase activity
A6B45_RS01030	COG0203	ribosomal protein L17
A6B45_RS01035	COG0142	geranyltranstransferase activity
A6B45_RS01045	COG1122	ATPase activity
A6B45_RS01050	COG1122	ATPase activity
A6B45_RS01055	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
A6B45_RS01060	COG0101	tRNA pseudouridine synthase activity
A6B45_RS01070	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
A6B45_RS01075	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
A6B45_RS01080	COG0583	DNA-binding transcription factor activity
A6B45_RS01085	COG1902	pentaerythritol trinitrate reductase activity
A6B45_RS01120	COG0149	triose-phosphate isomerase activity
A6B45_RS01125	COG0148	phosphopyruvate hydratase activity
A6B45_RS01130	COG0519	Catalyzes the synthesis of GMP from XMP
A6B45_RS01140	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
A6B45_RS01145	COG0248	Ppx GppA phosphatase
A6B45_RS01150	COG1739	Uncharacterized protein family UPF0029
A6B45_RS01155	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
A6B45_RS01160	COG1040	competence protein
A6B45_RS01175	COG0588	phosphoglycerate mutase activity
A6B45_RS01180	COG1253	flavin adenine dinucleotide binding
A6B45_RS01185	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
A6B45_RS01190	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A6B45_RS01195	COG1780	Probably involved in ribonucleotide reductase function
A6B45_RS01210	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
A6B45_RS01225	COG1077	Cell shape determining protein MreB Mrl
A6B45_RS01235	COG0772	Belongs to the SEDS family
A6B45_RS01245	COG1181	Belongs to the D-alanine--D-alanine ligase family
A6B45_RS01255	COG0267	Belongs to the bacterial ribosomal protein bL33 family
A6B45_RS01260	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A6B45_RS01270	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
A6B45_RS01275	COG0081	regulation of translation
A6B45_RS01280	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
A6B45_RS01285	COG0222	ribosome binding
A6B45_RS01290	COG2813	Specifically methylates the guanine in position
A6B45_RS01295	COG0590	tRNA wobble adenosine to inosine editing
A6B45_RS01310	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
A6B45_RS01315	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
A6B45_RS01325	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
A6B45_RS01330	COG3870	Protein conserved in bacteria
A6B45_RS01335	COG0470	DNA polymerase III
A6B45_RS01350	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
A6B45_RS01365	COG1609	Transcriptional regulator
A6B45_RS01375	COG1621	beta-fructofuranosidase activity
A6B45_RS01380	COG1940	carbohydrate kinase activity
A6B45_RS01395	COG1428	Deoxynucleoside kinase
A6B45_RS01400	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
A6B45_RS01405	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
A6B45_RS01415	COG0492	ferredoxin-NADP+ reductase activity
A6B45_RS01425	COG1418	mRNA catabolic process
A6B45_RS01430	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A6B45_RS01430	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A6B45_RS01435	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
A6B45_RS01435	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
A6B45_RS01465	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A6B45_RS01475	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A6B45_RS01480	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A6B45_RS01490	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
A6B45_RS01495	COG1028	Short-chain dehydrogenase reductase Sdr
A6B45_RS01500	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A6B45_RS01505	COG0511	ligase activity, forming carbon-carbon bonds
A6B45_RS01515	COG0439	Biotin carboxylase
A6B45_RS01520	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
A6B45_RS01565	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
A6B45_RS01590	COG0525	valine-tRNA ligase activity
A6B45_RS01595	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A6B45_RS01610	COG0791	NLP P60 protein
A6B45_RS01610	COG1388	LysM domain
A6B45_RS01610	COG3103	Sh3 type 3 domain protein
A6B45_RS01620	COG0768	penicillin binding
A6B45_RS01625	COG0640	Transcriptional regulator
A6B45_RS01635	COG0577	efflux transmembrane transporter activity
A6B45_RS01635	COG1136	(ABC) transporter
A6B45_RS01640	COG1316	TRANSCRIPTIONal
A6B45_RS01665	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
A6B45_RS01675	COG1914	H( )-stimulated, divalent metal cation uptake system
A6B45_RS01685	COG0640	Transcriptional regulator
A6B45_RS01700	COG1957	nucleoside hydrolase
A6B45_RS01705	COG0357	Ribosomal RNA small subunit methyltransferase G
A6B45_RS01710	COG1192	Involved in chromosome partitioning
A6B45_RS01715	COG1475	DNA binding
A6B45_RS01720	COG4481	Protein conserved in bacteria
A6B45_RS01725	COG0012	GTP binding
A6B45_RS01735	COG0745	RESPONSE REGULATOR receiver
A6B45_RS01740	COG2205	protein histidine kinase activity
A6B45_RS01750	COG0363	glucosamine-6-phosphate deaminase activity
A6B45_RS01755	COG0166	Belongs to the GPI family
A6B45_RS01765	COG4175	Glycine betaine
A6B45_RS01765	COG3448	diguanylate cyclase activity
A6B45_RS01785	COG4152	abc transporter atp-binding protein
A6B45_RS01820	COG0765	amino acid transport
A6B45_RS01825	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6B45_RS01830	COG0765	amino acid transport
A6B45_RS01835	COG1126	abc transporter atp-binding protein
A6B45_RS01840	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A6B45_RS01845	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A6B45_RS01850	COG1126	abc transporter atp-binding protein
A6B45_RS01855	COG2814	Major facilitator Superfamily
A6B45_RS01860	COG0343	queuine tRNA-ribosyltransferase activity
A6B45_RS01865	COG1862	Preprotein translocase
A6B45_RS01875	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
A6B45_RS01875	COG0392	lysyltransferase activity
A6B45_RS01890	COG0406	alpha-ribazole phosphatase activity
A6B45_RS01905	COG1132	(ABC) transporter
A6B45_RS01910	COG1132	(ABC) transporter
A6B45_RS01915	COG0438	transferase activity, transferring glycosyl groups
A6B45_RS01935	COG1368	sulfuric ester hydrolase activity
A6B45_RS01940	COG0556	nucleotide-excision repair
A6B45_RS01945	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A6B45_RS01950	COG0391	Required for morphogenesis under gluconeogenic growth conditions
A6B45_RS01955	COG1481	regulation of sporulation
A6B45_RS01960	COG0740	serine-type endopeptidase activity
A6B45_RS01970	COG0193	aminoacyl-tRNA hydrolase activity
A6B45_RS01975	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
A6B45_RS01980	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
A6B45_RS01990	COG0037	tRNA processing
A6B45_RS02000	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A6B45_RS02005	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
A6B45_RS02010	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
A6B45_RS02035	COG0217	transcriptional regulatory protein
A6B45_RS02040	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
A6B45_RS02050	COG2252	PERMEase
A6B45_RS02055	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A6B45_RS02095	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
A6B45_RS02105	COG2188	Transcriptional regulator
A6B45_RS02115	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A6B45_RS02125	COG1464	Belongs to the NlpA lipoprotein family
A6B45_RS02160	COG1744	ABC transporter substrate-binding protein PnrA-like
A6B45_RS02165	COG0765	amino acid transport
A6B45_RS02170	COG1126	abc transporter atp-binding protein
A6B45_RS02175	COG0765	amino acid transport
A6B45_RS02205	COG1733	regulation of RNA biosynthetic process
A6B45_RS02210	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
A6B45_RS02215	COG0072	phenylalanine-tRNA ligase activity
A6B45_RS02215	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A6B45_RS02220	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A6B45_RS02225	COG0254	rRNA binding
A6B45_RS02230	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A6B45_RS02235	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A6B45_RS02240	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A6B45_RS02255	COG2814	Major facilitator Superfamily
A6B45_RS02260	COG2003	Belongs to the UPF0758 family
A6B45_RS02265	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
A6B45_RS02270	COG2131	deaminase
A6B45_RS02275	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
A6B45_RS02280	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A6B45_RS02290	COG4537	Required for transformation and DNA binding
A6B45_RS02320	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
A6B45_RS02330	COG4975	Glucose uptake
A6B45_RS02335	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A6B45_RS02370	COG0683	leucine binding
A6B45_RS02385	COG0411	ABC transporter
A6B45_RS02395	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
A6B45_RS02400	COG0351	phosphomethylpyrimidine kinase
A6B45_RS02405	COG0352	thiamine-phosphate diphosphorylase activity
A6B45_RS02410	COG1012	belongs to the aldehyde dehydrogenase family
A6B45_RS02450	COG4493	Belongs to the UPF0637 family
A6B45_RS02455	COG0025	NhaP-type Na H and K H
A6B45_RS02460	COG1609	Transcriptional regulator
A6B45_RS02480	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A6B45_RS02490	COG0308	aminopeptidase N
A6B45_RS02500	COG2936	dipeptidyl-peptidase activity
A6B45_RS02510	COG1263	PTS System
A6B45_RS02510	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A6B45_RS02510	COG2190	(PTS) system
A6B45_RS02515	COG0366	Alpha amylase catalytic
A6B45_RS02520	COG2188	Transcriptional regulator
A6B45_RS02525	COG1078	dGTPase activity
A6B45_RS02535	COG3343	RNA polymerase activity
A6B45_RS02545	COG1113	amino acid transport
A6B45_RS02550	COG1268	BioY protein
A6B45_RS02560	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
A6B45_RS02560	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
A6B45_RS02565	COG0504	CTP synthase activity
A6B45_RS02570	COG0322	excinuclease ABC activity
A6B45_RS02575	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A6B45_RS02580	COG0028	Belongs to the TPP enzyme family
A6B45_RS02590	COG2309	aminopeptidase activity
A6B45_RS02600	COG0673	inositol 2-dehydrogenase activity
A6B45_RS02605	COG0513	Belongs to the DEAD box helicase family
A6B45_RS02610	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
A6B45_RS02620	COG0237	dephospho-CoA kinase activity
A6B45_RS02630	COG1484	DNA-dependent DNA replication
A6B45_RS02655	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
A6B45_RS02660	COG0416	fatty acid biosynthetic process
A6B45_RS02665	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A6B45_RS02670	COG3091	SprT-like family
A6B45_RS02675	COG0561	phosphatase activity
A6B45_RS02690	COG0006	proline dipeptidase activity
A6B45_RS02695	COG1609	Transcriptional regulator
A6B45_RS02700	COG2755	lipolytic protein G-D-S-L family
A6B45_RS02700	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
A6B45_RS02705	COG2814	Major facilitator Superfamily
A6B45_RS02720	COG3527	Alpha-acetolactate decarboxylase
A6B45_RS02725	COG1737	Transcriptional regulator
A6B45_RS02730	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
A6B45_RS02745	COG0531	amino acid
A6B45_RS02755	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A6B45_RS02760	COG4472	Bacterial protein of unknown function (DUF965)
A6B45_RS02765	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
A6B45_RS02770	COG3906	Belongs to the UPF0473 family
A6B45_RS02775	COG1271	oxidase subunit
A6B45_RS02780	COG1294	oxidase, subunit
A6B45_RS02785	COG4988	ABC transporter
A6B45_RS02790	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
A6B45_RS02795	COG1705	Flagellar rod assembly protein muramidase FlgJ
A6B45_RS02800	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A6B45_RS02815	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A6B45_RS02830	COG0542	response to heat
A6B45_RS02835	COG1077	Cell shape determining protein MreB Mrl
A6B45_RS02850	COG0765	amino acid transport
A6B45_RS02860	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6B45_RS02870	COG0612	Peptidase, M16
A6B45_RS02875	COG0612	Peptidase, M16
A6B45_RS02880	COG1426	Protein conserved in bacteria
A6B45_RS02885	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A6B45_RS02890	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
A6B45_RS02895	COG0745	RESPONSE REGULATOR receiver
A6B45_RS02905	COG5002	protein histidine kinase activity
A6B45_RS02915	COG0573	inorganic phosphate transmembrane transporter activity
A6B45_RS02920	COG0581	inorganic phosphate transmembrane transporter activity
A6B45_RS02925	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A6B45_RS02930	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A6B45_RS02935	COG0704	Plays a role in the regulation of phosphate uptake
A6B45_RS02940	COG1950	PFAM Membrane protein of
A6B45_RS02945	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
A6B45_RS02950	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
A6B45_RS02955	COG1210	Utp--glucose-1-phosphate uridylyltransferase
A6B45_RS02960	COG0492	ferredoxin-NADP+ reductase activity
A6B45_RS02975	COG1063	alcohol dehydrogenase
A6B45_RS02980	COG1609	Transcriptional regulator
A6B45_RS02990	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A6B45_RS02995	COG0335	large ribosomal subunit rRNA binding
A6B45_RS03000	COG1719	4-vinyl reductase, 4VR
A6B45_RS03005	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
A6B45_RS03010	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
A6B45_RS03020	COG2255	four-way junction helicase activity
A6B45_RS03030	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
A6B45_RS03035	COG0584	glycerophosphoryl diester phosphodiesterase
A6B45_RS03040	COG0632	four-way junction helicase activity
A6B45_RS03045	COG1428	Deoxynucleoside kinase
A6B45_RS03050	COG1970	mechanosensitive ion channel activity
A6B45_RS03055	COG0577	efflux transmembrane transporter activity
A6B45_RS03060	COG1136	(ABC) transporter
A6B45_RS03065	COG4684	Psort location CytoplasmicMembrane, score
A6B45_RS03075	COG4684	Psort location CytoplasmicMembrane, score
A6B45_RS03095	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A6B45_RS03100	COG1126	abc transporter atp-binding protein
A6B45_RS03105	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
A6B45_RS03115	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A6B45_RS03125	COG0671	phosphoesterase, PA-phosphatase related
A6B45_RS03130	COG0495	leucyl-tRNA aminoacylation
A6B45_RS03135	COG2244	polysaccharide biosynthetic process
A6B45_RS03150	COG1704	LemA family
A6B45_RS03155	COG0501	Belongs to the peptidase M48B family
A6B45_RS03160	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A6B45_RS03165	COG1942	4-Oxalocrotonate Tautomerase
A6B45_RS03175	COG3237	CsbD-like
A6B45_RS03180	COG0517	IMP dehydrogenase activity
A6B45_RS03180	COG0516	GMP reductase activity
A6B45_RS03185	COG0517	IMP dehydrogenase activity
A6B45_RS03185	COG0516	GMP reductase activity
A6B45_RS03200	COG3331	DNA recombination
A6B45_RS03210	COG4474	Belongs to the UPF0398 family
A6B45_RS03215	COG3599	regulation of cell shape
A6B45_RS03225	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6B45_RS03230	COG2706	6-phosphogluconolactonase activity
A6B45_RS03235	COG0628	permease
A6B45_RS03250	COG1674	ftsk spoiiie
A6B45_RS03250	COG1280	lysine exporter protein (LysE YggA)
A6B45_RS03255	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A6B45_RS03260	COG1113	amino acid transport
A6B45_RS03265	COG0586	Pfam SNARE associated Golgi protein
A6B45_RS03275	COG3001	Fructosamine kinase
A6B45_RS03285	COG2171	N-acyltransferase activity
A6B45_RS03290	COG1473	amidohydrolase
A6B45_RS03295	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A6B45_RS03300	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
A6B45_RS03305	COG2137	regulation of response to DNA damage stimulus
A6B45_RS03310	COG3557	Belongs to the UPF0374 family
A6B45_RS03315	COG0705	Rhomboid family
A6B45_RS03325	COG1940	carbohydrate kinase activity
A6B45_RS03335	COG2357	RelA SpoT domain protein
A6B45_RS03340	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
A6B45_RS03345	COG0564	pseudouridine synthase activity
A6B45_RS03350	COG2239	Acts as a magnesium transporter
A6B45_RS03360	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
A6B45_RS03365	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A6B45_RS03370	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
A6B45_RS03375	COG4589	Belongs to the CDS family
A6B45_RS03380	COG0750	zinc metalloprotease
A6B45_RS03385	COG0442	prolyl-tRNA aminoacylation
A6B45_RS03390	COG2176	DNA-directed DNA polymerase activity
A6B45_RS03405	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
A6B45_RS03405	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A6B45_RS03410	COG1744	ABC transporter substrate-binding protein PnrA-like
A6B45_RS03425	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A6B45_RS03430	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
A6B45_RS03440	COG0667	Aldo Keto reductase
A6B45_RS03445	COG0151	Belongs to the GarS family
A6B45_RS03450	COG2759	Belongs to the formate--tetrahydrofolate ligase family
A6B45_RS03455	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
A6B45_RS03460	COG1278	Cold shock
A6B45_RS03465	COG0494	nUDIX hydrolase
A6B45_RS03475	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A6B45_RS03480	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A6B45_RS03485	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A6B45_RS03500	COG1621	beta-fructofuranosidase activity
A6B45_RS03505	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A6B45_RS03505	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A6B45_RS03510	COG3764	Sortase (surface protein transpeptidase)
A6B45_RS03520	COG0789	Transcriptional regulator
A6B45_RS03525	COG0174	glutamine synthetase
A6B45_RS03530	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
A6B45_RS03535	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
A6B45_RS03540	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
A6B45_RS03545	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A6B45_RS03555	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A6B45_RS03565	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
A6B45_RS03570	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
A6B45_RS03575	COG0138	bifunctional purine biosynthesis protein purh
A6B45_RS03580	COG0420	3'-5' exonuclease activity
A6B45_RS03585	COG4717	serine-type aminopeptidase activity
A6B45_RS03605	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A6B45_RS03615	COG0095	Lipoate-protein ligase
A6B45_RS03630	COG0508	dehydrogenase complex catalyzes the overall conversion of
A6B45_RS03640	COG2267	carboxylic ester hydrolase activity
A6B45_RS03645	COG0584	glycerophosphoryl diester phosphodiesterase
A6B45_RS03665	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A6B45_RS03670	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A6B45_RS03680	COG0351	phosphomethylpyrimidine kinase
A6B45_RS03685	COG1169	isochorismate synthase
A6B45_RS03690	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
A6B45_RS03710	COG0617	tRNA 3'-terminal CCA addition
A6B45_RS03720	COG1307	EDD domain protein, DegV family
A6B45_RS03740	COG2755	lipolytic protein G-D-S-L family
A6B45_RS03750	COG4479	Belongs to the UPF0346 family
A6B45_RS03755	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
A6B45_RS03760	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
A6B45_RS03770	COG1122	ATPase activity
A6B45_RS03785	COG2384	SAM-dependent methyltransferase
A6B45_RS03790	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
A6B45_RS03805	COG0587	DNA-directed DNA polymerase activity
A6B45_RS03815	COG0004	ammonium transporteR
A6B45_RS03820	COG1702	phosphate starvation-inducible protein PhoH
A6B45_RS03825	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
A6B45_RS03835	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
A6B45_RS03840	COG1381	Involved in DNA repair and RecF pathway recombination
A6B45_RS03845	COG0252	asparaginase activity
A6B45_RS03855	COG0527	aspartate kinase activity
A6B45_RS03860	COG0083	homoserine kinase activity
A6B45_RS03865	COG0460	homoserine dehydrogenase
A6B45_RS03870	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
A6B45_RS03875	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
A6B45_RS03880	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
A6B45_RS03890	COG0183	Belongs to the thiolase family
A6B45_RS03895	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A6B45_RS03920	COG1609	Transcriptional regulator
A6B45_RS03925	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A6B45_RS03945	COG0517	IMP dehydrogenase activity
A6B45_RS03945	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
A6B45_RS03950	COG2877	3-deoxy-8-phosphooctulonate synthase activity
A6B45_RS03965	COG1121	(ABC) transporter
A6B45_RS03970	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A6B45_RS03990	COG0415	Belongs to the DNA photolyase family
A6B45_RS03995	COG0577	efflux transmembrane transporter activity
A6B45_RS04005	COG1309	transcriptional regulator
A6B45_RS04010	COG2409	Drug exporters of the RND superfamily
A6B45_RS04010	COG1033	growth of symbiont in host cell
A6B45_RS04025	COG0070	glutamate synthase
A6B45_RS04025	COG0067	glutamate synthase
A6B45_RS04025	COG0069	glutamate synthase activity
A6B45_RS04030	COG0493	'glutamate synthase
A6B45_RS04050	COG0307	riboflavin synthase, alpha
A6B45_RS04060	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
A6B45_RS04065	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
A6B45_RS04075	COG0738	Major facilitator superfamily
A6B45_RS04080	COG0366	Alpha amylase catalytic
A6B45_RS04085	COG1609	Transcriptional regulator
A6B45_RS04090	COG0693	protein deglycase activity
A6B45_RS04095	COG0745	RESPONSE REGULATOR receiver
A6B45_RS04100	COG5002	protein histidine kinase activity
A6B45_RS04105	COG1136	(ABC) transporter
A6B45_RS04115	COG0667	Aldo Keto reductase
A6B45_RS04125	COG2207	Transcriptional regulator
A6B45_RS04130	COG1874	Beta-galactosidase
A6B45_RS04160	COG0789	Transcriptional regulator
A6B45_RS04175	COG1609	Transcriptional regulator
A6B45_RS04180	COG2160	L-arabinose isomerase activity
A6B45_RS04205	COG5263	repeat protein
A6B45_RS04205	COG0366	Alpha amylase catalytic
A6B45_RS04210	COG1028	Short-chain dehydrogenase reductase Sdr
A6B45_RS04215	COG2261	transglycosylase associated protein
A6B45_RS04240	COG2261	transglycosylase associated protein
A6B45_RS04250	COG2814	Major facilitator Superfamily
A6B45_RS04255	COG5039	Polysaccharide pyruvyl transferase
A6B45_RS04280	COG1472	Belongs to the glycosyl hydrolase 3 family
A6B45_RS04305	COG1609	Transcriptional regulator
A6B45_RS04315	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
A6B45_RS04320	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
A6B45_RS04330	COG2207	Transcriptional regulator
A6B45_RS04330	COG1609	Transcriptional regulator
A6B45_RS04365	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A6B45_RS04375	COG0366	Alpha amylase catalytic
A6B45_RS04390	COG3711	transcriptional antiterminator
A6B45_RS04400	COG2723	6-phospho-beta-galactosidase activity
A6B45_RS04405	COG1956	GAF domain-containing protein
A6B45_RS04410	COG2244	polysaccharide biosynthetic process
A6B45_RS04415	COG1609	Transcriptional regulator
A6B45_RS04430	COG0366	Alpha amylase catalytic
A6B45_RS04445	COG1215	transferase activity, transferring glycosyl groups
A6B45_RS04460	COG0300	oxidoreductase activity
A6B45_RS04470	COG0477	Major facilitator Superfamily
A6B45_RS04475	COG1063	alcohol dehydrogenase
A6B45_RS04480	COG1573	uracil-dna glycosylase
A6B45_RS04485	COG4720	Psort location CytoplasmicMembrane, score
A6B45_RS04490	COG0693	protein deglycase activity
A6B45_RS04515	COG1028	Short-chain dehydrogenase reductase Sdr
A6B45_RS04520	COG2610	gluconate transmembrane transporter activity
A6B45_RS04525	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
A6B45_RS04540	COG2723	6-phospho-beta-galactosidase activity
A6B45_RS04550	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6B45_RS04550	COG3711	transcriptional antiterminator
A6B45_RS04555	COG1447	Phosphotransferase system cellobiose-specific component IIA
A6B45_RS04565	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A6B45_RS04575	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
A6B45_RS04585	COG1733	regulation of RNA biosynthetic process
A6B45_RS04590	COG1846	Transcriptional regulator
A6B45_RS04610	COG1442	glycosyl transferase family 8
A6B45_RS04615	COG1121	(ABC) transporter
A6B45_RS04620	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A6B45_RS04630	COG3527	Alpha-acetolactate decarboxylase
A6B45_RS04640	COG1316	TRANSCRIPTIONal
A6B45_RS04645	COG1846	Transcriptional regulator
A6B45_RS04650	COG2814	Major facilitator Superfamily
A6B45_RS04655	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
A6B45_RS04675	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A6B45_RS04680	COG0300	oxidoreductase activity
A6B45_RS04690	COG2364	Membrane
A6B45_RS04695	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A6B45_RS04710	COG0028	Belongs to the TPP enzyme family
A6B45_RS04715	COG0071	Belongs to the small heat shock protein (HSP20) family
A6B45_RS04760	COG0745	RESPONSE REGULATOR receiver
A6B45_RS04765	COG5002	protein histidine kinase activity
A6B45_RS04765	COG3850	Histidine kinase
A6B45_RS04785	COG0655	NAD(P)H dehydrogenase (quinone) activity
A6B45_RS04825	COG1129	ABC transporter
A6B45_RS04845	COG2270	Major facilitator Superfamily
A6B45_RS04865	COG0583	DNA-binding transcription factor activity
A6B45_RS04880	COG2176	DNA-directed DNA polymerase activity
A6B45_RS04975	COG4336	lyase activity
A6B45_RS04980	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
A6B45_RS04985	COG1914	H( )-stimulated, divalent metal cation uptake system
A6B45_RS04990	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
A6B45_RS04995	COG1984	allophanate hydrolase subunit 2
A6B45_RS05030	COG0577	efflux transmembrane transporter activity
A6B45_RS05035	COG1136	(ABC) transporter
A6B45_RS05035	COG0577	efflux transmembrane transporter activity
A6B45_RS05075	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A6B45_RS05095	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
A6B45_RS05110	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A6B45_RS05210	COG0542	response to heat
A6B45_RS05245	COG1192	Involved in chromosome partitioning
A6B45_RS05325	COG2826	transposase and inactivated derivatives, IS30 family
A6B45_RS05365	COG3158	transport of potassium into the cell
A6B45_RS05425	COG0433	COG0433 Predicted ATPase
A6B45_RS05450	COG1674	ftsk spoiiie
A6B45_RS05530	COG2169	Transcriptional regulator
A6B45_RS05530	COG1917	Cupin 2, conserved barrel domain protein
A6B45_RS05535	COG2197	response regulator
A6B45_RS05540	COG4585	Histidine kinase
A6B45_RS05545	COG2409	Drug exporters of the RND superfamily
A6B45_RS05560	COG2814	Major facilitator Superfamily
A6B45_RS05570	COG1028	Short-chain dehydrogenase reductase Sdr
A6B45_RS05580	COG0318	PFAM AMP-dependent synthetase and ligase
A6B45_RS05590	COG1116	anion transmembrane transporter activity
A6B45_RS05595	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A6B45_RS05610	COG0395	ABC-type sugar transport system, permease component
A6B45_RS05620	COG3842	ATPase activity
A6B45_RS05625	COG0710	3-dehydroquinate dehydratase activity
A6B45_RS05635	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
A6B45_RS05640	COG0287	Prephenate dehydrogenase
A6B45_RS05645	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
A6B45_RS05650	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
A6B45_RS05655	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
A6B45_RS05660	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
A6B45_RS05670	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
A6B45_RS05675	COG0512	Glutamine amidotransferase of anthranilate synthase
A6B45_RS05680	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A6B45_RS05685	COG0159	tryptophan synthase activity
A6B45_RS05695	COG0134	indole-3-glycerol-phosphate synthase activity
A6B45_RS05700	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A6B45_RS05725	COG2848	UPF0210 protein
A6B45_RS05745	COG3425	synthase
A6B45_RS05750	COG0488	(ABC) transporter
A6B45_RS05760	COG1385	rRNA (uridine-N3-)-methyltransferase activity
A6B45_RS05765	COG2264	protein methyltransferase activity
A6B45_RS05785	COG0673	inositol 2-dehydrogenase activity
A6B45_RS05790	COG0751	glycine-tRNA ligase activity
A6B45_RS05795	COG0752	glycyl-tRNA synthetase alpha subunit
A6B45_RS05805	COG0233	cytoplasmic translational termination
A6B45_RS05810	COG0528	UMP kinase activity
A6B45_RS05815	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
A6B45_RS05820	COG0052	Belongs to the universal ribosomal protein uS2 family
A6B45_RS05825	COG2827	Endonuclease containing a URI domain
A6B45_RS05830	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
A6B45_RS05835	COG0204	Acyl-transferase
A6B45_RS05840	COG3763	UPF0154 protein
A6B45_RS05845	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
A6B45_RS05855	COG0284	orotidine-5'-phosphate decarboxylase activity
A6B45_RS05860	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
A6B45_RS05865	COG0505	Belongs to the CarA family
A6B45_RS05870	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A6B45_RS05875	COG0540	Belongs to the ATCase OTCase family
A6B45_RS05885	COG3679	Belongs to the UPF0342 family
A6B45_RS05890	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A6B45_RS05895	COG1438	arginine binding
A6B45_RS05900	COG0018	arginyl-trna synthetase
A6B45_RS05910	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
A6B45_RS05965	COG0220	tRNA (guanine-N7-)-methyltransferase activity
A6B45_RS05975	COG1131	(ABC) transporter
A6B45_RS05980	COG0537	adenosine 5'-monophosphoramidase activity
A6B45_RS05990	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A6B45_RS06005	COG0436	Aminotransferase
A6B45_RS06010	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A6B45_RS06040	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A6B45_RS06045	COG0358	DNA primase activity
A6B45_RS06055	COG3716	PTS system mannose fructose sorbose family IID component
A6B45_RS06085	COG0758	DNA mediated transformation
A6B45_RS06090	COG0488	(ABC) transporter
A6B45_RS06095	COG0167	dihydroorotate dehydrogenase activity
A6B45_RS06100	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
A6B45_RS06105	COG0860	N-Acetylmuramoyl-L-alanine amidase
A6B45_RS06115	COG2183	response to ionizing radiation
A6B45_RS06135	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A6B45_RS06140	COG0626	cystathionine gamma-synthase activity
A6B45_RS06145	COG1045	serine acetyltransferase
A6B45_RS06155	COG0776	regulation of translation
A6B45_RS06160	COG1160	GTP binding
A6B45_RS06165	COG0539	negative regulation of cytoplasmic translation
A6B45_RS06170	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
A6B45_RS06180	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
A6B45_RS06185	COG1187	pseudouridine synthase activity
A6B45_RS06190	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
A6B45_RS06195	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
A6B45_RS06205	COG4974	Belongs to the 'phage' integrase family
A6B45_RS06210	COG2996	Protein conserved in bacteria
A6B45_RS06215	COG1610	YqeY-like protein
A6B45_RS06220	COG0828	Belongs to the bacterial ribosomal protein bS21 family
A6B45_RS06225	COG0477	Major facilitator Superfamily
A6B45_RS06230	COG2508	Transcriptional regulator
A6B45_RS06235	COG1113	amino acid transport
A6B45_RS06240	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A6B45_RS06245	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
A6B45_RS06250	COG0124	histidyl-tRNA synthetase
A6B45_RS06255	COG2017	converts alpha-aldose to the beta-anomer
A6B45_RS06260	COG2207	Transcriptional regulator
A6B45_RS06265	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
A6B45_RS06275	COG0406	alpha-ribazole phosphatase activity
A6B45_RS06280	COG0584	glycerophosphoryl diester phosphodiesterase
A6B45_RS06295	COG1175	transmembrane transport
A6B45_RS06305	COG0667	Aldo Keto reductase
A6B45_RS06310	COG3250	beta-galactosidase activity
A6B45_RS06320	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A6B45_RS06325	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A6B45_RS06335	COG4470	Protein conserved in bacteria
A6B45_RS06340	COG0737	Belongs to the 5'-nucleotidase family
A6B45_RS06350	COG0006	proline dipeptidase activity
A6B45_RS06355	COG0211	Belongs to the bacterial ribosomal protein bL27 family
A6B45_RS06360	COG0261	This protein binds to 23S rRNA in the presence of protein L20
A6B45_RS06395	COG1247	-acetyltransferase
A6B45_RS06400	COG2962	Rard protein
A6B45_RS06425	COG1217	gtp-binding protein TYPA
A6B45_RS06430	COG0483	inositol monophosphate 1-phosphatase activity
A6B45_RS06435	COG4476	Belongs to the UPF0223 family
A6B45_RS06440	COG0242	peptide deformylase activity
A6B45_RS06445	COG0484	heat shock protein binding
A6B45_RS06450	COG0443	Heat shock 70 kDa protein
A6B45_RS06455	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
A6B45_RS06460	COG1420	regulation of RNA biosynthetic process
A6B45_RS06465	COG0196	riboflavin kinase activity
A6B45_RS06470	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
A6B45_RS06480	COG0436	Aminotransferase
A6B45_RS06485	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
A6B45_RS06490	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
A6B45_RS06500	COG2740	Nucleic-acid-binding protein implicated in transcription termination
A6B45_RS06505	COG0195	Participates in both transcription termination and antitermination
A6B45_RS06510	COG0779	Required for maturation of 30S ribosomal subunits
A6B45_RS06515	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
A6B45_RS06520	COG0267	Belongs to the bacterial ribosomal protein bL33 family
A6B45_RS06525	COG1227	inorganic diphosphatase activity
A6B45_RS06535	COG0187	DNA topoisomerase II activity
A6B45_RS06545	COG1490	D-aminoacyl-tRNA deacylase activity
A6B45_RS06550	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A6B45_RS06570	COG0505	Belongs to the CarA family
A6B45_RS06575	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
A6B45_RS06580	COG0564	pseudouridine synthase activity
A6B45_RS06590	COG0328	RNA-DNA hybrid ribonuclease activity
A6B45_RS06600	COG0436	Aminotransferase
A6B45_RS06605	COG0116	Belongs to the methyltransferase superfamily
A6B45_RS06620	COG0017	Asparaginyl-tRNA synthetase
A6B45_RS06635	COG1199	ATP-dependent helicase activity
A6B45_RS06635	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A6B45_RS06655	COG1304	FMN binding
A6B45_RS06665	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A6B45_RS06670	COG2116	formate transmembrane transporter activity
A6B45_RS06675	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A6B45_RS06680	COG0716	FMN binding
A6B45_RS06690	COG1216	Glycosyl transferase, family 2
A6B45_RS06730	COG0463	Glycosyl transferase, family 2
A6B45_RS06735	COG0562	UDP-galactopyranose mutase
A6B45_RS06825	COG1091	dTDP-4-dehydrorhamnose reductase activity
A6B45_RS06830	COG1088	dTDP-glucose 4,6-dehydratase activity
A6B45_RS06840	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
A6B45_RS06860	COG1215	transferase activity, transferring glycosyl groups
A6B45_RS06890	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A6B45_RS06895	COG0489	protein tyrosine kinase activity
A6B45_RS06910	COG0024	Methionine aminopeptidase
A6B45_RS06915	COG1316	TRANSCRIPTIONal
A6B45_RS06920	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
A6B45_RS06925	COG1114	Component of the transport system for branched-chain amino acids
A6B45_RS06930	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
A6B45_RS06935	COG0291	Belongs to the bacterial ribosomal protein bL35 family
A6B45_RS06955	COG0333	Belongs to the bacterial ribosomal protein bL32 family
A6B45_RS06960	COG3142	Participates in the control of copper homeostasis
A6B45_RS06990	COG0165	Argininosuccinate lyase
A6B45_RS06995	COG0137	argininosuccinate synthase activity
A6B45_RS07000	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
A6B45_RS07005	COG0217	transcriptional regulatory protein
A6B45_RS07015	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A6B45_RS07020	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
A6B45_RS07035	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
A6B45_RS07065	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A6B45_RS07070	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
A6B45_RS07070	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
A6B45_RS07075	COG1234	tRNA 3'-trailer cleavage
A6B45_RS07080	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A6B45_RS07085	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
A6B45_RS07090	COG0336	Belongs to the RNA methyltransferase TrmD family
A6B45_RS07095	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
A6B45_RS07105	COG1074	ATP-dependent DNA helicase activity
A6B45_RS07110	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
A6B45_RS07125	COG0228	four-way junction DNA binding
A6B45_RS07150	COG0762	integral membrane protein
A6B45_RS07155	COG1799	cell septum assembly
A6B45_RS07170	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
A6B45_RS07175	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A6B45_RS07180	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
A6B45_RS07185	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A6B45_RS07190	COG0768	penicillin binding
A6B45_RS07200	COG0275	rRNA processing
A6B45_RS07205	COG2001	Belongs to the MraZ family
A6B45_RS07220	COG1461	Dihydroxyacetone kinase
A6B45_RS07230	COG0227	Belongs to the bacterial ribosomal protein bL28 family
A6B45_RS07235	COG3118	belongs to the thioredoxin family
A6B45_RS07245	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
A6B45_RS07250	COG1162	GTPase activity
A6B45_RS07255	COG2815	serine threonine protein kinase
A6B45_RS07255	COG0515	serine threonine protein kinase
A6B45_RS07260	COG0631	protein serine/threonine phosphatase activity
A6B45_RS07270	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
A6B45_RS07275	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
A6B45_RS07290	COG3201	nicotinamide mononucleotide transporter
A6B45_RS07295	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A6B45_RS07300	COG0218	Necessary for normal cell division and for the maintenance of normal septation
A6B45_RS07305	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
A6B45_RS07315	COG4974	Belongs to the 'phage' integrase family
A6B45_RS07330	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
A6B45_RS07335	COG0544	peptidyl-prolyl cis-trans isomerase activity
A6B45_RS07340	COG1335	isochorismatase
A6B45_RS07345	COG0531	amino acid
A6B45_RS07355	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A6B45_RS07365	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
A6B45_RS07370	COG0708	Exodeoxyribonuclease III
A6B45_RS07375	COG2176	DNA-directed DNA polymerase activity
A6B45_RS07380	COG0456	acetyltransferase
A6B45_RS07385	COG0802	atpase or kinase
A6B45_RS07420	COG0602	queuosine metabolic process
A6B45_RS07425	COG1328	CTP reductase activity
A6B45_RS07430	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
A6B45_RS07435	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
A6B45_RS07465	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A6B45_RS07480	COG0107	imidazoleglycerol-phosphate synthase activity
A6B45_RS07485	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
A6B45_RS07495	COG0131	Imidazoleglycerol-phosphate dehydratase
A6B45_RS07500	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
A6B45_RS07515	COG2199	diguanylate cyclase activity
A6B45_RS07515	COG2200	EAL domain
A6B45_RS07520	COG1215	transferase activity, transferring glycosyl groups
A6B45_RS07530	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
A6B45_RS07535	COG0561	phosphatase activity
A6B45_RS07545	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A6B45_RS07555	COG0552	protein localization to endoplasmic reticulum
A6B45_RS07560	COG1196	nuclear chromosome segregation
A6B45_RS07565	COG0571	ribonuclease III activity
A6B45_RS07570	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A6B45_RS07590	COG0812	UDP-N-acetylmuramate dehydrogenase activity
A6B45_RS07595	COG0105	UTP biosynthetic process
A6B45_RS07600	COG4807	Protein conserved in bacteria
A6B45_RS07605	COG3237	CsbD-like
A6B45_RS07635	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
A6B45_RS07640	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
A6B45_RS07645	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A6B45_RS07650	COG1597	lipid kinase activity
A6B45_RS07660	COG0154	amidase activity
A6B45_RS07665	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A6B45_RS07670	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
A6B45_RS07675	COG0268	Binds directly to 16S ribosomal RNA
A6B45_RS07680	COG0513	Belongs to the DEAD box helicase family
A6B45_RS07685	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
A6B45_RS07690	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A6B45_RS07695	COG1466	dna polymerase III delta subunit
A6B45_RS07700	COG2333	competence protein COMEC
A6B45_RS07700	COG0658	competence protein
A6B45_RS07705	COG1596	polysaccharide export
A6B45_RS07705	COG1555	photosystem II stabilization
A6B45_RS07710	COG3480	Lon protease (S16) C-terminal proteolytic domain
A6B45_RS07715	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
A6B45_RS07720	COG0742	ribosomal rna small subunit methyltransferase
A6B45_RS07725	COG4471	UPF0298 protein
A6B45_RS07730	COG0772	Belongs to the SEDS family
A6B45_RS07735	COG1363	Peptidase, m42
A6B45_RS07740	COG0588	phosphoglycerate mutase activity
A6B45_RS07745	COG0534	Mate efflux family protein
A6B45_RS07750	COG2252	PERMEase
A6B45_RS07755	COG0497	DNA recombination
A6B45_RS07760	COG1438	arginine binding
A6B45_RS07765	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
A6B45_RS07770	COG0142	geranyltranstransferase activity
A6B45_RS07775	COG1722	exodeoxyribonuclease VII activity
A6B45_RS07780	COG1570	exodeoxyribonuclease VII activity
A6B45_RS07795	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
A6B45_RS07800	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A6B45_RS07805	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A6B45_RS07810	COG1121	(ABC) transporter
A6B45_RS07820	COG4466	Protein conserved in bacteria
A6B45_RS07825	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A6B45_RS07830	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
A6B45_RS07835	COG0084	hydrolase, TatD family'
A6B45_RS07840	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A6B45_RS07845	COG1302	Protein conserved in bacteria
A6B45_RS07850	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
A6B45_RS07865	COG1984	allophanate hydrolase subunit 2
A6B45_RS07870	COG0439	Biotin carboxylase
A6B45_RS07875	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
A6B45_RS07885	COG2814	Major facilitator Superfamily
A6B45_RS07890	COG0583	DNA-binding transcription factor activity
A6B45_RS07895	COG1063	alcohol dehydrogenase
A6B45_RS07900	COG2814	Major facilitator Superfamily
A6B45_RS07905	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
A6B45_RS07910	COG1611	Belongs to the LOG family
A6B45_RS07915	COG5503	Protein of unknown function (DUF1447)
A6B45_RS08040	COG3728	DNA packaging
A6B45_RS08040	COG5484	DNA packaging
A6B45_RS08125	COG3723	Recombinational DNA repair protein, rece pathway
A6B45_RS08195	COG3152	Membrane
A6B45_RS08205	COG1892	Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four- carbon dicarboxylic acid source for the tricarboxylic acid cycle
A6B45_RS08220	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
A6B45_RS08230	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
A6B45_RS08235	COG0584	glycerophosphoryl diester phosphodiesterase
A6B45_RS08250	COG4862	establishment of competence for transformation
A6B45_RS08255	COG1393	Belongs to the ArsC family
A6B45_RS08285	COG1098	S1 RNA binding domain
A6B45_RS08295	COG1758	RNA polymerase activity
A6B45_RS08300	COG0194	GDP metabolic process
A6B45_RS08320	COG1193	negative regulation of DNA recombination
A6B45_RS08340	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
A6B45_RS08355	COG1418	mRNA catabolic process
A6B45_RS08360	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
A6B45_RS08365	COG0557	exoribonuclease II activity
A6B45_RS08375	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A6B45_RS08380	COG0706	membrane insertase activity
A6B45_RS08385	COG1254	Belongs to the acylphosphatase family
A6B45_RS08390	COG5002	protein histidine kinase activity
A6B45_RS08395	COG0745	RESPONSE REGULATOR receiver
A6B45_RS08405	COG1323	Belongs to the UPF0348 family
A6B45_RS08410	COG2226	methyltransferase
A6B45_RS08415	COG0799	negative regulation of ribosome biogenesis
A6B45_RS08420	COG1713	HD superfamily hydrolase involved in NAD metabolism
A6B45_RS08425	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
A6B45_RS08430	COG1534	Rna-binding protein
A6B45_RS08435	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
A6B45_RS08440	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
A6B45_RS08465	COG1959	2 iron, 2 sulfur cluster binding
A6B45_RS08470	COG5263	repeat protein
A6B45_RS08470	COG0366	Alpha amylase catalytic
A6B45_RS08495	COG5263	repeat protein
A6B45_RS08495	COG0366	Alpha amylase catalytic
A6B45_RS08525	COG2323	membrane
A6B45_RS08535	COG3579	cysteine-type endopeptidase activity
A6B45_RS08540	COG0477	Major facilitator Superfamily
A6B45_RS08550	COG0459	protein refolding
A6B45_RS08555	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
A6B45_RS08570	COG3716	PTS system mannose fructose sorbose family IID component
A6B45_RS08575	COG3715	PTS system
A6B45_RS08585	COG1482	cell wall glycoprotein biosynthetic process
A6B45_RS08590	COG0778	Nitroreductase
A6B45_RS08600	COG0561	phosphatase activity
A6B45_RS08610	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
A6B45_RS08615	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
A6B45_RS08630	COG1214	PFAM Peptidase M22, glycoprotease
A6B45_RS08635	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A6B45_RS08645	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
A6B45_RS08650	COG0009	L-threonylcarbamoyladenylate synthase
A6B45_RS08655	COG2890	protein-(glutamine-N5) methyltransferase activity
A6B45_RS08660	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
A6B45_RS08665	COG1435	thymidine kinase activity
A6B45_RS08670	COG0791	NLP P60 protein
A6B45_RS08670	COG3883	PFAM NLP P60 protein
A6B45_RS08675	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
A6B45_RS08680	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
A6B45_RS08685	COG0302	gtp cyclohydrolase
A6B45_RS08690	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
A6B45_RS08690	COG0302	gtp cyclohydrolase
A6B45_RS08700	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A6B45_RS08705	COG3442	glutamine amidotransferase
A6B45_RS08710	COG0531	amino acid
A6B45_RS08720	COG0628	permease
A6B45_RS08725	COG2040	homocysteine
A6B45_RS08730	COG0833	amino acid
A6B45_RS08735	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
A6B45_RS08740	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
A6B45_RS08745	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
A6B45_RS08750	COG4166	transmembrane transport
A6B45_RS08755	COG2873	o-acetylhomoserine
A6B45_RS08760	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
A6B45_RS08765	COG1854	S-ribosylhomocysteine lyase activity
A6B45_RS08770	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
A6B45_RS08775	COG0626	cystathionine gamma-synthase activity
A6B45_RS08780	COG0626	cystathionine gamma-synthase activity
A6B45_RS08785	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
A6B45_RS08790	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A6B45_RS08795	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A6B45_RS08800	COG5002	protein histidine kinase activity
A6B45_RS08805	COG0745	RESPONSE REGULATOR receiver
A6B45_RS08810	COG2337	Toxic component of a toxin-antitoxin (TA) module
A6B45_RS08815	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A6B45_RS08820	COG0736	holo-[acyl-carrier-protein] synthase activity
A6B45_RS08825	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
A6B45_RS08830	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A6B45_RS08835	COG1696	Membrane protein involved in D-alanine export
A6B45_RS08840	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A6B45_RS08865	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A6B45_RS08870	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
A6B45_RS08875	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
A6B45_RS08880	COG0085	RNA polymerase activity
A6B45_RS08945	COG0436	Aminotransferase
A6B45_RS08950	COG0194	GDP metabolic process
A6B45_RS08955	COG0531	amino acid
A6B45_RS08960	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
A6B45_RS08965	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
A6B45_RS08980	COG5506	Protein of unknown function (DUF1694)
A6B45_RS08985	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A6B45_RS09000	COG0833	amino acid
A6B45_RS09010	COG1316	TRANSCRIPTIONal
A6B45_RS09020	COG4166	transmembrane transport
A6B45_RS09025	COG1181	Belongs to the D-alanine--D-alanine ligase family
A6B45_RS09025	COG2918	glutathione biosynthetic process
A6B45_RS09030	COG0531	amino acid
A6B45_RS09040	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A6B45_RS09055	COG0628	permease
A6B45_RS09060	COG1194	a g-specific adenine glycosylase
A6B45_RS09065	COG2814	Major facilitator Superfamily
A6B45_RS09070	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A6B45_RS09080	COG1902	pentaerythritol trinitrate reductase activity
A6B45_RS09085	COG1705	Flagellar rod assembly protein muramidase FlgJ
A6B45_RS09085	COG1388	LysM domain
A6B45_RS09090	COG0737	Belongs to the 5'-nucleotidase family
A6B45_RS09095	COG3639	organic phosphonate transmembrane transporter activity
A6B45_RS09105	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
A6B45_RS09115	COG0355	proton-transporting ATP synthase activity, rotational mechanism
A6B45_RS09120	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
A6B45_RS09125	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
A6B45_RS09130	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
A6B45_RS09135	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A6B45_RS09140	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
A6B45_RS09145	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A6B45_RS09150	COG0356	it plays a direct role in the translocation of protons across the membrane
A6B45_RS09160	COG0588	phosphoglycerate mutase activity
A6B45_RS09165	COG1278	Cold shock
A6B45_RS09175	COG2814	Major facilitator Superfamily
A6B45_RS09180	COG1072	(Pantothenic acid kinase))
A6B45_RS09185	COG3973	AAA domain
A6B45_RS09230	COG0318	PFAM AMP-dependent synthetase and ligase
A6B45_RS09255	COG1511	domain protein
A6B45_RS09255	COG1511	domain protein
A6B45_RS09260	COG1309	transcriptional regulator
A6B45_RS09270	COG0697	spore germination
A6B45_RS09280	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A6B45_RS09290	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
A6B45_RS09305	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A6B45_RS09360	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
A6B45_RS09360	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
A6B45_RS09365	COG0488	(ABC) transporter
A6B45_RS09385	COG1064	alcohol dehydrogenase
A6B45_RS09395	COG0126	phosphoglycerate kinase activity
A6B45_RS09425	COG3590	peptidase
A6B45_RS09430	COG4608	Belongs to the ABC transporter superfamily
A6B45_RS09435	COG0444	Belongs to the ABC transporter superfamily
A6B45_RS09440	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A6B45_RS09445	COG0601	transmembrane transport
A6B45_RS09450	COG4166	transmembrane transport
A6B45_RS09455	COG0765	amino acid transport
A6B45_RS09460	COG0765	amino acid transport
A6B45_RS09465	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6B45_RS09470	COG1126	abc transporter atp-binding protein
A6B45_RS09475	COG1132	(ABC) transporter
A6B45_RS09480	COG1132	(ABC) transporter
A6B45_RS09490	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A6B45_RS09495	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A6B45_RS09500	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
A6B45_RS09505	COG1959	2 iron, 2 sulfur cluster binding
A6B45_RS09510	COG1511	domain protein
A6B45_RS09515	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
A6B45_RS09520	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A6B45_RS09540	COG0745	RESPONSE REGULATOR receiver
A6B45_RS09545	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
A6B45_RS09560	COG0473	3-isopropylmalate dehydrogenase activity
A6B45_RS09570	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A6B45_RS09575	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
A6B45_RS09585	COG0028	Belongs to the TPP enzyme family
A6B45_RS09590	COG1119	ATPase activity
A6B45_RS09595	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
A6B45_RS09600	COG2188	Transcriptional regulator
A6B45_RS09605	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
A6B45_RS09615	COG0737	Belongs to the 5'-nucleotidase family
A6B45_RS09620	COG0305	Participates in initiation and elongation during chromosome replication
A6B45_RS09625	COG0359	binds to the 23S rRNA
A6B45_RS09635	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
A6B45_RS09640	COG0629	single-stranded DNA binding
A6B45_RS09645	COG0360	Binds together with S18 to 16S ribosomal RNA
A6B45_RS09650	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A6B45_RS09660	COG1122	ATPase activity
A6B45_RS09665	COG4720	Psort location CytoplasmicMembrane, score
A6B45_RS09675	COG0514	ATP-dependent DNA helicase (RecQ)
A6B45_RS09740	COG3866	Pectate lyase
A6B45_RS09745	COG2084	Dehydrogenase
A6B45_RS09775	COG3623	hexulose-6-phosphate isomerase
A6B45_RS09810	COG0561	phosphatase activity
A6B45_RS09825	COG3402	PFAM membrane-flanked domain
A6B45_RS09830	COG0583	DNA-binding transcription factor activity
A6B45_RS09835	COG1113	amino acid transport
A6B45_RS09840	COG1757	Na H antiporter
A6B45_RS09850	COG1902	pentaerythritol trinitrate reductase activity
A6B45_RS09855	COG1733	regulation of RNA biosynthetic process
A6B45_RS09860	COG0667	Aldo Keto reductase
A6B45_RS09870	COG0667	Aldo Keto reductase
A6B45_RS09875	COG2814	Major facilitator Superfamily
A6B45_RS09885	COG1686	Belongs to the peptidase S11 family
A6B45_RS09895	COG0803	Belongs to the bacterial solute-binding protein 9 family
A6B45_RS09900	COG2226	methyltransferase
A6B45_RS09905	COG0318	PFAM AMP-dependent synthetase and ligase
A6B45_RS09915	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
A6B45_RS09945	COG0066	3-isopropylmalate dehydratase activity
A6B45_RS09950	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
A6B45_RS09955	COG0473	3-isopropylmalate dehydrogenase activity
A6B45_RS09960	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A6B45_RS09965	COG2151	metal-sulfur cluster biosynthetic enzyme
A6B45_RS09970	COG0719	Fe-S assembly protein
A6B45_RS09980	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A6B45_RS09985	COG0719	Fe-S assembly protein
A6B45_RS09990	COG0396	ATPase activity
A6B45_RS10000	COG0129	dihydroxy-acid dehydratase activity
A6B45_RS10005	COG2151	metal-sulfur cluster biosynthetic enzyme
A6B45_RS10020	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
A6B45_RS10035	COG1983	PspC domain protein
A6B45_RS10045	COG2918	glutathione biosynthetic process
A6B45_RS10045	COG1181	Belongs to the D-alanine--D-alanine ligase family
A6B45_RS10050	COG0577	efflux transmembrane transporter activity
A6B45_RS10055	COG1136	(ABC) transporter
A6B45_RS10085	COG2855	membrane
A6B45_RS10105	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A6B45_RS10125	COG0706	membrane insertase activity
A6B45_RS10130	COG0594	ribonuclease P activity
A6B45_RS10135	COG0230	Belongs to the bacterial ribosomal protein bL34 family
A6B45_RS10140	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A6B45_RS10145	COG0446	pyridine nucleotide-disulphide oxidoreductase
A6B45_RS10155	COG2084	Dehydrogenase
A6B45_RS10160	COG0561	phosphatase activity
A6B45_RS10205	COG1715	Restriction endonuclease
A6B45_RS10210	COG0783	Belongs to the Dps family
A6B45_RS10215	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A6B45_RS10220	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
A6B45_RS10225	COG2217	Heavy metal translocating P-type atpase
A6B45_RS10235	COG2217	Heavy metal translocating P-type atpase
A6B45_RS10245	COG0735	belongs to the Fur family
A6B45_RS10275	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A6B45_RS10285	COG0640	Transcriptional regulator
A6B45_RS10290	COG2217	Heavy metal translocating P-type atpase
A6B45_RS10330	COG0228	four-way junction DNA binding