locus-tag	class	description
S101174_RS00025	COG1285	pathogenesis
S101174_RS00040	COG3158	transport of potassium into the cell
S101174_RS00050	COG2826	transposase and inactivated derivatives, IS30 family
S101174_RS00055	COG2826	transposase and inactivated derivatives, IS30 family
S101174_RS00070	COG1192	Involved in chromosome partitioning
S101174_RS00105	COG2826	transposase and inactivated derivatives, IS30 family
S101174_RS00135	COG0551	DNA topoisomerase type I activity
S101174_RS00135	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
S101174_RS00140	COG2826	transposase and inactivated derivatives, IS30 family
S101174_RS00190	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
S101174_RS00200	COG0592	DNA-directed DNA polymerase activity
S101174_RS00205	COG2501	S4 domain
S101174_RS00210	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
S101174_RS00215	COG0187	DNA topoisomerase II activity
S101174_RS00220	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
S101174_RS00225	COG0360	Binds together with S18 to 16S ribosomal RNA
S101174_RS00230	COG0629	single-stranded DNA binding
S101174_RS00235	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
S101174_RS00245	COG4166	transmembrane transport
S101174_RS00260	COG4166	transmembrane transport
S101174_RS00280	COG0359	binds to the 23S rRNA
S101174_RS00290	COG2211	Major facilitator Superfamily
S101174_RS00295	COG3507	Belongs to the glycosyl hydrolase 43 family
S101174_RS00300	COG0305	Participates in initiation and elongation during chromosome replication
S101174_RS00315	COG0655	NAD(P)H dehydrogenase (quinone) activity
S101174_RS00320	COG2814	Major facilitator Superfamily
S101174_RS00330	COG4166	transmembrane transport
S101174_RS00350	COG0745	RESPONSE REGULATOR receiver
S101174_RS00370	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
S101174_RS00375	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
S101174_RS00380	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
S101174_RS00400	COG0737	Belongs to the 5'-nucleotidase family
S101174_RS00455	COG1397	ADP-ribosylglycohydrolase
S101174_RS00460	COG0110	maltose O-acetyltransferase activity
S101174_RS00465	COG2801	Transposase and inactivated derivatives
S101174_RS00495	COG4166	transmembrane transport
S101174_RS00540	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
S101174_RS00565	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
S101174_RS00605	COG0076	glutamate decarboxylase activity
S101174_RS00610	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
S101174_RS00650	COG0702	epimerase
S101174_RS00680	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
S101174_RS00700	COG2746	aminoglycoside 3-N-acetyltransferase activity
S101174_RS00705	COG0667	Aldo Keto reductase
S101174_RS00715	COG2814	Major facilitator Superfamily
S101174_RS00725	COG0778	Nitroreductase
S101174_RS00735	COG0488	(ABC) transporter
S101174_RS00740	COG0477	Major facilitator Superfamily
S101174_RS00750	COG1028	Short-chain dehydrogenase reductase Sdr
S101174_RS00755	COG1609	Transcriptional regulator
S101174_RS00760	COG1253	flavin adenine dinucleotide binding
S101174_RS00775	COG0531	amino acid
S101174_RS00780	COG0656	L-ascorbic acid biosynthetic process
S101174_RS00785	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
S101174_RS00800	COG1012	belongs to the aldehyde dehydrogenase family
S101174_RS00800	COG1454	alcohol dehydrogenase
S101174_RS00805	COG1388	LysM domain
S101174_RS00805	COG0791	NLP P60 protein
S101174_RS00815	COG0791	NLP P60 protein
S101174_RS00815	COG1388	LysM domain
S101174_RS00835	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
S101174_RS00840	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
S101174_RS00845	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
S101174_RS00860	COG1131	(ABC) transporter
S101174_RS00865	COG1418	mRNA catabolic process
S101174_RS00875	COG1904	glucuronate isomerase
S101174_RS00880	COG2211	Major facilitator Superfamily
S101174_RS00890	COG3250	beta-galactosidase activity
S101174_RS00895	COG0246	Mannitol dehydrogenase
S101174_RS00905	COG0588	phosphoglycerate mutase activity
S101174_RS00910	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
S101174_RS00915	COG1070	Carbohydrate kinase
S101174_RS00920	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
S101174_RS00930	COG1312	Catalyzes the dehydration of D-mannonate
S101174_RS00935	COG1609	Transcriptional regulator
S101174_RS00940	COG2211	Major facilitator Superfamily
S101174_RS00950	COG1904	glucuronate isomerase
S101174_RS00965	COG0477	Major facilitator Superfamily
S101174_RS00985	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
S101174_RS00990	COG2188	Transcriptional regulator
S101174_RS01000	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
S101174_RS01030	COG0564	pseudouridine synthase activity
S101174_RS01065	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
S101174_RS01070	COG0601	transmembrane transport
S101174_RS01075	COG4608	Belongs to the ABC transporter superfamily
S101174_RS01090	COG0095	Lipoate-protein ligase
S101174_RS01105	COG2115	Belongs to the xylose isomerase family
S101174_RS01125	COG5646	InterPro IPR014922
S101174_RS01140	COG1881	PFAM PEBP family protein
S101174_RS01160	COG0656	L-ascorbic acid biosynthetic process
S101174_RS01175	COG1757	Na H antiporter
S101174_RS01185	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
S101174_RS01190	COG3290	protein histidine kinase activity
S101174_RS01195	COG4565	transcriptional regulatory protein
S101174_RS01205	COG1309	transcriptional regulator
S101174_RS01240	COG3479	Phenolic acid decarboxylase
S101174_RS01245	COG1695	Transcriptional regulator
S101174_RS01260	COG2153	protein acetylation
S101174_RS01265	COG1846	Transcriptional regulator
S101174_RS01295	COG1914	H( )-stimulated, divalent metal cation uptake system
S101174_RS01300	COG0516	GMP reductase activity
S101174_RS01305	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
S101174_RS01310	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
S101174_RS01315	COG1309	transcriptional regulator
S101174_RS01325	COG2365	Tyrosine phosphatase family
S101174_RS01345	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
S101174_RS01375	COG1335	isochorismatase
S101174_RS01395	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
S101174_RS01400	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
S101174_RS01405	COG0716	FMN binding
S101174_RS01415	COG1113	amino acid transport
S101174_RS01440	COG1064	alcohol dehydrogenase
S101174_RS01450	COG0517	IMP dehydrogenase activity
S101174_RS01450	COG1125	glycine betaine transport
S101174_RS01460	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
S101174_RS01475	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
S101174_RS01495	COG0110	maltose O-acetyltransferase activity
S101174_RS01520	COG1686	Belongs to the peptidase S11 family
S101174_RS01525	COG0656	L-ascorbic acid biosynthetic process
S101174_RS01535	COG2801	Transposase and inactivated derivatives
S101174_RS01540	COG2217	Heavy metal translocating P-type atpase
S101174_RS01550	COG0726	polysaccharide deacetylase
S101174_RS01560	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
S101174_RS01615	COG1942	4-Oxalocrotonate Tautomerase
S101174_RS01630	COG1174	glycine betaine transport
S101174_RS01635	COG1732	Glycine betaine
S101174_RS01665	COG2837	iron assimilation
S101174_RS01685	COG0463	Glycosyl transferase, family 2
S101174_RS01700	COG0628	permease
S101174_RS01705	COG0577	efflux transmembrane transporter activity
S101174_RS01710	COG1136	(ABC) transporter
S101174_RS01715	COG0366	Alpha amylase catalytic
S101174_RS01735	COG0028	Belongs to the TPP enzyme family
S101174_RS01755	COG0745	RESPONSE REGULATOR receiver
S101174_RS01765	COG0702	epimerase
S101174_RS01770	COG1252	NADH dehydrogenase
S101174_RS01775	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
S101174_RS01785	COG1012	belongs to the aldehyde dehydrogenase family
S101174_RS01790	COG1414	Transcriptional regulator
S101174_RS01805	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
S101174_RS01810	COG1028	Short-chain dehydrogenase reductase Sdr
S101174_RS01820	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
S101174_RS01840	COG1914	H( )-stimulated, divalent metal cation uptake system
S101174_RS01850	COG1307	EDD domain protein, DegV family
S101174_RS01855	COG0446	pyridine nucleotide-disulphide oxidoreductase
S101174_RS01860	COG3118	belongs to the thioredoxin family
S101174_RS01865	COG1937	Protein conserved in bacteria
S101174_RS01870	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
S101174_RS01875	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
S101174_RS01885	COG0657	acetylesterase activity
S101174_RS01890	COG1854	S-ribosylhomocysteine lyase activity
S101174_RS01900	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
S101174_RS01910	COG0583	DNA-binding transcription factor activity
S101174_RS01960	COG0745	RESPONSE REGULATOR receiver
S101174_RS01965	COG5002	protein histidine kinase activity
S101174_RS01970	COG1609	Transcriptional regulator
S101174_RS01990	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
S101174_RS01995	COG2017	converts alpha-aldose to the beta-anomer
S101174_RS02005	COG0561	phosphatase activity
S101174_RS02020	COG1393	Belongs to the ArsC family
S101174_RS02025	COG0791	NLP P60 protein
S101174_RS02025	COG1388	LysM domain
S101174_RS02025	COG3103	Sh3 type 3 domain protein
S101174_RS02045	COG1028	Short-chain dehydrogenase reductase Sdr
S101174_RS02050	COG2211	Major facilitator Superfamily
S101174_RS02060	COG2207	Transcriptional regulator
S101174_RS02065	COG1028	Short-chain dehydrogenase reductase Sdr
S101174_RS02075	COG1959	2 iron, 2 sulfur cluster binding
S101174_RS02080	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
S101174_RS02090	COG1733	regulation of RNA biosynthetic process
S101174_RS02095	COG2814	Major facilitator Superfamily
S101174_RS02100	COG4989	oxidoreductase activity
S101174_RS02105	COG1136	(ABC) transporter
S101174_RS02130	COG2217	Heavy metal translocating P-type atpase
S101174_RS02155	COG2855	membrane
S101174_RS02160	COG0583	DNA-binding transcription factor activity
S101174_RS02165	COG2814	Major facilitator Superfamily
S101174_RS02175	COG0488	(ABC) transporter
S101174_RS02210	COG1725	Transcriptional regulator
S101174_RS02215	COG1131	(ABC) transporter
S101174_RS02225	COG3835	regulator
S101174_RS02230	COG2610	gluconate transmembrane transporter activity
S101174_RS02235	COG1929	Belongs to the glycerate kinase type-1 family
S101174_RS02240	COG3428	Bacterial PH domain
S101174_RS02285	COG1914	H( )-stimulated, divalent metal cation uptake system
S101174_RS02295	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
S101174_RS02320	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
S101174_RS02325	COG2323	membrane
S101174_RS02385	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
S101174_RS02400	COG1609	Transcriptional regulator
S101174_RS02415	COG3973	AAA domain
S101174_RS02425	COG0248	Ppx GppA phosphatase
S101174_RS02440	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
S101174_RS02450	COG1801	Protein of unknown function DUF72
S101174_RS02455	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
S101174_RS02455	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
S101174_RS02460	COG0084	hydrolase, TatD family'
S101174_RS02465	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
S101174_RS02470	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
S101174_RS02475	COG4466	Protein conserved in bacteria
S101174_RS02480	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
S101174_RS02485	COG1573	uracil-dna glycosylase
S101174_RS02520	COG2723	6-phospho-beta-galactosidase activity
S101174_RS02525	COG1940	carbohydrate kinase activity
S101174_RS02550	COG1121	(ABC) transporter
S101174_RS02555	COG1108	ABC-type Mn2 Zn2 transport systems permease components
S101174_RS02560	COG2826	transposase and inactivated derivatives, IS30 family
S101174_RS02570	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
S101174_RS02575	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
S101174_RS02580	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
S101174_RS02595	COG2188	Transcriptional regulator
S101174_RS02600	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
S101174_RS02605	COG0561	phosphatase activity
S101174_RS02610	COG1078	dGTPase activity
S101174_RS02615	COG0095	Lipoate-protein ligase
S101174_RS02625	COG3343	RNA polymerase activity
S101174_RS02630	COG0504	CTP synthase activity
S101174_RS02650	COG0028	Belongs to the TPP enzyme family
S101174_RS02655	COG3527	Alpha-acetolactate decarboxylase
S101174_RS02665	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
S101174_RS02670	COG0254	rRNA binding
S101174_RS02675	COG3764	Sortase (surface protein transpeptidase)
S101174_RS02730	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
S101174_RS02735	COG1704	LemA family
S101174_RS02740	COG0501	Belongs to the peptidase M48B family
S101174_RS02750	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
S101174_RS02765	COG0736	holo-[acyl-carrier-protein] synthase activity
S101174_RS02770	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
S101174_RS02780	COG2337	Toxic component of a toxin-antitoxin (TA) module
S101174_RS02800	COG0193	aminoacyl-tRNA hydrolase activity
S101174_RS02805	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
S101174_RS02810	COG2244	polysaccharide biosynthetic process
S101174_RS02815	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
S101174_RS02825	COG1098	S1 RNA binding domain
S101174_RS02830	COG0037	tRNA processing
S101174_RS02845	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
S101174_RS02850	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
S101174_RS02895	COG3104	oligopeptide transport
S101174_RS02915	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
S101174_RS02920	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
S101174_RS02925	COG2188	Transcriptional regulator
S101174_RS02940	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
S101174_RS02945	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
S101174_RS02955	COG2183	response to ionizing radiation
S101174_RS02960	COG3091	SprT-like family
S101174_RS02965	COG0083	homoserine kinase activity
S101174_RS02995	COG0534	Mate efflux family protein
S101174_RS03010	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
S101174_RS03010	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S101174_RS03015	COG3715	PTS system
S101174_RS03020	COG3716	PTS system mannose fructose sorbose family IID component
S101174_RS03025	COG0628	permease
S101174_RS03045	COG1511	domain protein
S101174_RS03050	COG0803	Belongs to the bacterial solute-binding protein 9 family
S101174_RS03055	COG1316	TRANSCRIPTIONal
S101174_RS03065	COG0697	spore germination
S101174_RS03085	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
S101174_RS03095	COG0756	dUTP diphosphatase activity
S101174_RS03105	COG4956	integral membrane protein (PIN domain superfamily)
S101174_RS03110	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
S101174_RS03115	COG0215	cysteine-tRNA ligase activity
S101174_RS03120	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
S101174_RS03125	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
S101174_RS03130	COG3688	RNA-binding protein containing a PIN domain
S101174_RS03140	COG0267	Belongs to the bacterial ribosomal protein bL33 family
S101174_RS03150	COG0250	Participates in transcription elongation, termination and antitermination
S101174_RS03155	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
S101174_RS03160	COG0081	regulation of translation
S101174_RS03165	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
S101174_RS03170	COG0222	ribosome binding
S101174_RS03175	COG2826	transposase and inactivated derivatives, IS30 family
S101174_RS03185	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
S101174_RS03185	COG0392	lysyltransferase activity
S101174_RS03195	COG1250	3-hydroxyacyl-CoA dehydrogenase
S101174_RS03200	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
S101174_RS03210	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
S101174_RS03215	COG2813	Specifically methylates the guanine in position
S101174_RS03230	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
S101174_RS03235	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
S101174_RS03240	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
S101174_RS03250	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
S101174_RS03255	COG3870	Protein conserved in bacteria
S101174_RS03260	COG0470	DNA polymerase III
S101174_RS03265	COG4467	Involved in initiation control of chromosome replication
S101174_RS03280	COG1214	PFAM Peptidase M22, glycoprotease
S101174_RS03290	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
S101174_RS03295	COG2807	transmembrane transport
S101174_RS03300	COG0640	Transcriptional regulator
S101174_RS03305	COG0488	(ABC) transporter
S101174_RS03310	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
S101174_RS03315	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
S101174_RS03320	COG0459	protein refolding
S101174_RS03325	COG0531	amino acid
S101174_RS03335	COG1346	cytolysis
S101174_RS03345	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
S101174_RS03350	COG1739	Uncharacterized protein family UPF0029
S101174_RS03355	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
S101174_RS03370	COG0653	protein targeting
S101174_RS03385	COG0745	RESPONSE REGULATOR receiver
S101174_RS03390	COG5002	protein histidine kinase activity
S101174_RS03400	COG0573	inorganic phosphate transmembrane transporter activity
S101174_RS03405	COG0581	inorganic phosphate transmembrane transporter activity
S101174_RS03410	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
S101174_RS03415	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
S101174_RS03420	COG0704	Plays a role in the regulation of phosphate uptake
S101174_RS03425	COG1983	PspC domain protein
S101174_RS03435	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
S101174_RS03440	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
S101174_RS03445	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
S101174_RS03450	COG1210	Utp--glucose-1-phosphate uridylyltransferase
S101174_RS03455	COG0492	ferredoxin-NADP+ reductase activity
S101174_RS03470	COG0556	nucleotide-excision repair
S101174_RS03475	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
S101174_RS03485	COG1660	Displays ATPase and GTPase activities
S101174_RS03490	COG0391	Required for morphogenesis under gluconeogenic growth conditions
S101174_RS03495	COG1481	regulation of sporulation
S101174_RS03500	COG0740	serine-type endopeptidase activity
S101174_RS03520	COG4684	Psort location CytoplasmicMembrane, score
S101174_RS03540	COG0126	phosphoglycerate kinase activity
S101174_RS03545	COG0149	triose-phosphate isomerase activity
S101174_RS03550	COG0148	phosphopyruvate hydratase activity
S101174_RS03560	COG0038	chloride channel
S101174_RS03565	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
S101174_RS03575	COG0557	exoribonuclease II activity
S101174_RS03580	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
S101174_RS03595	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
S101174_RS03600	COG0280	phosphate acetyltransferase
S101174_RS03605	COG0802	atpase or kinase
S101174_RS03615	COG0667	Aldo Keto reductase
S101174_RS03625	COG0708	Exodeoxyribonuclease III
S101174_RS03635	COG0025	NhaP-type Na H and K H
S101174_RS03645	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
S101174_RS03655	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
S101174_RS03660	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
S101174_RS03670	COG0363	glucosamine-6-phosphate deaminase activity
S101174_RS03675	COG1388	LysM domain
S101174_RS03675	COG1705	Flagellar rod assembly protein muramidase FlgJ
S101174_RS03695	COG1134	teichoic acid transport
S101174_RS03725	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
S101174_RS03730	COG1120	ATPase activity
S101174_RS03735	COG0248	Ppx GppA phosphatase
S101174_RS03740	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
S101174_RS03750	COG3475	LICD family
S101174_RS03775	COG3759	membrane
S101174_RS03795	COG1609	Transcriptional regulator
S101174_RS03815	COG2235	arginine
S101174_RS03835	COG3655	Transcriptional regulator
S101174_RS03905	COG0745	RESPONSE REGULATOR receiver
S101174_RS03910	COG5002	protein histidine kinase activity
S101174_RS03910	COG3850	Histidine kinase
S101174_RS03920	COG4975	Glucose uptake
S101174_RS03925	COG0166	Belongs to the GPI family
S101174_RS03935	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
S101174_RS03955	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
S101174_RS04020	COG4695	Portal protein
S101174_RS04040	COG1278	Cold shock
S101174_RS04055	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
S101174_RS04060	COG3706	GGDEF domain
S101174_RS04060	COG2203	Gaf domain
S101174_RS04060	COG4251	negative regulation of phosphorylation
S101174_RS04060	COG5001	Diguanylate cyclase
S101174_RS04105	COG3442	glutamine amidotransferase
S101174_RS04110	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
S101174_RS04115	COG1435	thymidine kinase activity
S101174_RS04120	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
S101174_RS04125	COG2890	protein-(glutamine-N5) methyltransferase activity
S101174_RS04130	COG0009	L-threonylcarbamoyladenylate synthase
S101174_RS04135	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
S101174_RS04140	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
S101174_RS04145	COG0356	it plays a direct role in the translocation of protons across the membrane
S101174_RS04150	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
S101174_RS04155	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
S101174_RS04160	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
S101174_RS04165	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
S101174_RS04170	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
S101174_RS04175	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
S101174_RS04180	COG0355	proton-transporting ATP synthase activity, rotational mechanism
S101174_RS04190	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
S101174_RS04195	COG1077	Cell shape determining protein MreB Mrl
S101174_RS04200	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
S101174_RS04210	COG0772	Belongs to the SEDS family
S101174_RS04215	COG0509	glycine decarboxylation via glycine cleavage system
S101174_RS04230	COG1181	Belongs to the D-alanine--D-alanine ligase family
S101174_RS04245	COG0589	response to stress
S101174_RS04255	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
S101174_RS04265	COG4493	Belongs to the UPF0637 family
S101174_RS04275	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
S101174_RS04280	COG1956	GAF domain-containing protein
S101174_RS04285	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
S101174_RS04290	COG1104	cysteine desulfurase activity
S101174_RS04295	COG0301	tRNA thio-modification
S101174_RS04305	COG0525	valine-tRNA ligase activity
S101174_RS04310	COG0285	dihydrofolate synthase activity
S101174_RS04315	COG2003	Belongs to the UPF0758 family
S101174_RS04320	COG1077	Cell shape determining protein MreB Mrl
S101174_RS04325	COG1792	Involved in formation and maintenance of cell shape
S101174_RS04335	COG0850	regulation of cytokinetic process
S101174_RS04340	COG2894	cell division
S101174_RS04345	COG0765	amino acid transport
S101174_RS04350	COG1126	abc transporter atp-binding protein
S101174_RS04355	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
S101174_RS04360	COG0612	Peptidase, M16
S101174_RS04365	COG0612	Peptidase, M16
S101174_RS04370	COG1426	Protein conserved in bacteria
S101174_RS04375	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
S101174_RS04380	COG1546	Belongs to the CinA family
S101174_RS04380	COG1058	Belongs to the CinA family
S101174_RS04385	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
S101174_RS04400	COG1418	mRNA catabolic process
S101174_RS04405	COG1692	metallophosphoesterase
S101174_RS04410	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
S101174_RS04415	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
S101174_RS04420	COG0632	four-way junction helicase activity
S101174_RS04425	COG2255	four-way junction helicase activity
S101174_RS04430	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
S101174_RS04435	COG0343	queuine tRNA-ribosyltransferase activity
S101174_RS04445	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
S101174_RS04450	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
S101174_RS04455	COG0513	Belongs to the DEAD box helicase family
S101174_RS04460	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
S101174_RS04465	COG4472	Bacterial protein of unknown function (DUF965)
S101174_RS04470	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
S101174_RS04475	COG3906	Belongs to the UPF0473 family
S101174_RS04490	COG1193	negative regulation of DNA recombination
S101174_RS04495	COG3118	belongs to the thioredoxin family
S101174_RS04500	COG1719	4-vinyl reductase, 4VR
S101174_RS04505	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
S101174_RS04510	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
S101174_RS04520	COG0517	IMP dehydrogenase activity
S101174_RS04525	COG0640	Transcriptional regulator
S101174_RS04535	COG0668	transmembrane transport
S101174_RS04550	COG0006	proline dipeptidase activity
S101174_RS04555	COG1609	Transcriptional regulator
S101174_RS04565	COG1126	abc transporter atp-binding protein
S101174_RS04570	COG0765	amino acid transport
S101174_RS04575	COG0217	transcriptional regulatory protein
S101174_RS04580	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
S101174_RS04585	COG1459	type II secretion system
S101174_RS04590	COG4537	Required for transformation and DNA binding
S101174_RS04610	COG0827	DNA restriction-modification system
S101174_RS04625	COG0656	L-ascorbic acid biosynthetic process
S101174_RS04635	COG0737	Belongs to the 5'-nucleotidase family
S101174_RS04640	COG4470	Protein conserved in bacteria
S101174_RS04645	COG0647	UMP catabolic process
S101174_RS04670	COG0531	amino acid
S101174_RS04675	COG1028	Short-chain dehydrogenase reductase Sdr
S101174_RS04685	COG0586	Pfam SNARE associated Golgi protein
S101174_RS04690	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
S101174_RS04695	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
S101174_RS04700	COG0539	negative regulation of cytoplasmic translation
S101174_RS04820	COG1234	tRNA 3'-trailer cleavage
S101174_RS04825	COG1393	Belongs to the ArsC family
S101174_RS04830	COG4862	establishment of competence for transformation
S101174_RS05050	COG5484	DNA packaging
S101174_RS05240	COG1215	transferase activity, transferring glycosyl groups
S101174_RS05250	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
S101174_RS05255	COG0671	phosphoesterase, PA-phosphatase related
S101174_RS05260	COG0495	leucyl-tRNA aminoacylation
S101174_RS05270	COG1129	ABC transporter
S101174_RS05285	COG2244	polysaccharide biosynthetic process
S101174_RS05290	COG1187	pseudouridine synthase activity
S101174_RS05295	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
S101174_RS05305	COG0589	response to stress
S101174_RS05315	COG1113	amino acid transport
S101174_RS05325	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
S101174_RS05330	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
S101174_RS05335	COG1674	ftsk spoiiie
S101174_RS05340	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
S101174_RS05360	COG0402	S-adenosylhomocysteine deaminase activity
S101174_RS05365	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
S101174_RS05365	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
S101174_RS05370	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
S101174_RS05375	COG0237	dephospho-CoA kinase activity
S101174_RS05380	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
S101174_RS05390	COG1484	DNA-dependent DNA replication
S101174_RS05395	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
S101174_RS05400	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
S101174_RS05405	COG0291	Belongs to the bacterial ribosomal protein bL35 family
S101174_RS05410	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
S101174_RS05415	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
S101174_RS05420	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
S101174_RS05430	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
S101174_RS05435	COG1713	HD superfamily hydrolase involved in NAD metabolism
S101174_RS05440	COG0799	negative regulation of ribosome biogenesis
S101174_RS05445	COG2226	methyltransferase
S101174_RS05450	COG1323	Belongs to the UPF0348 family
S101174_RS05460	COG0333	Belongs to the bacterial ribosomal protein bL32 family
S101174_RS05465	COG0561	phosphatase activity
S101174_RS05470	COG0640	Transcriptional regulator
S101174_RS05475	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
S101174_RS05475	COG5549	protein import
S101174_RS05480	COG1064	alcohol dehydrogenase
S101174_RS05485	COG0745	RESPONSE REGULATOR receiver
S101174_RS05490	COG5002	protein histidine kinase activity
S101174_RS05500	COG0706	membrane insertase activity
S101174_RS05505	COG1254	Belongs to the acylphosphatase family
S101174_RS05510	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
S101174_RS05520	COG1733	regulation of RNA biosynthetic process
S101174_RS05525	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
S101174_RS05530	COG0072	phenylalanine-tRNA ligase activity
S101174_RS05530	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
S101174_RS05535	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
S101174_RS05540	COG0572	uridine kinase
S101174_RS05545	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
S101174_RS05560	COG2155	Conserved Protein
S101174_RS05565	COG0768	penicillin binding
S101174_RS05570	COG0267	Belongs to the bacterial ribosomal protein bL33 family
S101174_RS05575	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
S101174_RS05580	COG0705	Rhomboid family
S101174_RS05580	COG0457	Tetratricopeptide repeat
S101174_RS05590	COG1940	carbohydrate kinase activity
S101174_RS05605	COG0584	glycerophosphoryl diester phosphodiesterase
S101174_RS05610	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
S101174_RS05615	COG0789	Transcriptional regulator
S101174_RS05645	COG0261	This protein binds to 23S rRNA in the presence of protein L20
S101174_RS05650	COG2868	ribosomal protein
S101174_RS05655	COG0211	Belongs to the bacterial ribosomal protein bL27 family
S101174_RS05660	COG0006	proline dipeptidase activity
S101174_RS05665	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
S101174_RS05670	COG1302	Protein conserved in bacteria
S101174_RS05675	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
S101174_RS05680	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
S101174_RS05685	COG1570	exodeoxyribonuclease VII activity
S101174_RS05690	COG1722	exodeoxyribonuclease VII activity
S101174_RS05700	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
S101174_RS05705	COG1438	arginine binding
S101174_RS05710	COG0497	DNA recombination
S101174_RS05725	COG0194	GDP metabolic process
S101174_RS05730	COG1758	RNA polymerase activity
S101174_RS05735	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
S101174_RS05740	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
S101174_RS05745	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
S101174_RS05750	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
S101174_RS05750	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
S101174_RS05755	COG0631	protein serine/threonine phosphatase activity
S101174_RS05760	COG0515	serine threonine protein kinase
S101174_RS05760	COG2815	serine threonine protein kinase
S101174_RS05765	COG1162	GTPase activity
S101174_RS05770	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
S101174_RS05775	COG1564	THIamine pyrophosphokinase
S101174_RS05780	COG0227	Belongs to the bacterial ribosomal protein bL28 family
S101174_RS05785	COG1302	Protein conserved in bacteria
S101174_RS05790	COG1461	Dihydroxyacetone kinase
S101174_RS05795	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
S101174_RS05800	COG0416	fatty acid biosynthetic process
S101174_RS05805	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
S101174_RS05810	COG0571	ribonuclease III activity
S101174_RS05815	COG1196	nuclear chromosome segregation
S101174_RS05820	COG0552	protein localization to endoplasmic reticulum
S101174_RS05825	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
S101174_RS05830	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
S101174_RS05855	COG0228	four-way junction DNA binding
S101174_RS05860	COG1837	Belongs to the UPF0109 family
S101174_RS05865	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
S101174_RS05870	COG0336	Belongs to the RNA methyltransferase TrmD family
S101174_RS05875	COG0335	large ribosomal subunit rRNA binding
S101174_RS05885	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
S101174_RS05895	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
S101174_RS05900	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
S101174_RS05910	COG1028	Short-chain dehydrogenase reductase Sdr
S101174_RS05920	COG0511	ligase activity, forming carbon-carbon bonds
S101174_RS05925	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
S101174_RS05930	COG0439	Biotin carboxylase
S101174_RS05935	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
S101174_RS05940	COG0825	malonyl-CoA metabolic process
S101174_RS05945	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
S101174_RS05955	COG1268	BioY protein
S101174_RS05960	COG1694	Mazg nucleotide pyrophosphohydrolase
S101174_RS05985	COG0693	protein deglycase activity
S101174_RS06010	COG0583	DNA-binding transcription factor activity
S101174_RS06015	COG0789	Transcriptional regulator
S101174_RS06020	COG0667	Aldo Keto reductase
S101174_RS06025	COG1162	GTPase activity
S101174_RS06065	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
S101174_RS06070	COG1942	4-Oxalocrotonate Tautomerase
S101174_RS06075	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
S101174_RS06085	COG3655	Transcriptional regulator
S101174_RS06100	COG1215	transferase activity, transferring glycosyl groups
S101174_RS06110	COG0577	efflux transmembrane transporter activity
S101174_RS06110	COG1136	(ABC) transporter
S101174_RS06120	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
S101174_RS06155	COG1309	transcriptional regulator
S101174_RS06160	COG1304	FMN binding
S101174_RS06170	COG0025	NhaP-type Na H and K H
S101174_RS06185	COG2807	transmembrane transport
S101174_RS06190	COG3158	transport of potassium into the cell
S101174_RS06205	COG0789	Transcriptional regulator
S101174_RS06230	COG0583	DNA-binding transcription factor activity
S101174_RS06250	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
S101174_RS06260	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
S101174_RS06260	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
S101174_RS06265	COG1304	FMN binding
S101174_RS06285	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
S101174_RS06285	COG1199	ATP-dependent helicase activity
S101174_RS06315	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
S101174_RS06320	COG3331	DNA recombination
S101174_RS06325	COG4474	Belongs to the UPF0398 family
S101174_RS06330	COG3599	regulation of cell shape
S101174_RS06340	COG0116	Belongs to the methyltransferase superfamily
S101174_RS06350	COG0004	ammonium transporteR
S101174_RS06385	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
S101174_RS06400	COG2759	Belongs to the formate--tetrahydrofolate ligase family
S101174_RS06405	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
S101174_RS06410	COG0564	pseudouridine synthase activity
S101174_RS06415	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
S101174_RS06425	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
S101174_RS06430	COG1293	RNA-binding protein homologous to eukaryotic snRNP
S101174_RS06435	COG1846	Transcriptional regulator
S101174_RS06445	COG2270	Major facilitator Superfamily
S101174_RS06450	COG1307	EDD domain protein, DegV family
S101174_RS06455	COG4720	Psort location CytoplasmicMembrane, score
S101174_RS06460	COG2246	polysaccharide biosynthetic process
S101174_RS06475	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
S101174_RS06495	COG2226	methyltransferase
S101174_RS06505	COG4974	Belongs to the 'phage' integrase family
S101174_RS06520	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
S101174_RS06530	COG1227	inorganic diphosphatase activity
S101174_RS06535	COG0583	DNA-binding transcription factor activity
S101174_RS06545	COG0187	DNA topoisomerase II activity
S101174_RS06550	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
S101174_RS06560	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
S101174_RS06565	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
S101174_RS06575	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
S101174_RS06580	COG0758	DNA mediated transformation
S101174_RS06585	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
S101174_RS06590	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
S101174_RS06620	COG4479	Belongs to the UPF0346 family
S101174_RS06630	COG2755	lipolytic protein G-D-S-L family
S101174_RS06635	COG1307	EDD domain protein, DegV family
S101174_RS06640	COG1272	protein, Hemolysin III
S101174_RS06650	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
S101174_RS06655	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
S101174_RS06660	COG0488	(ABC) transporter
S101174_RS06665	COG0617	tRNA 3'-terminal CCA addition
S101174_RS06670	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
S101174_RS06675	COG0457	Tetratricopeptide repeat
S101174_RS06685	COG1160	GTP binding
S101174_RS06690	COG0539	negative regulation of cytoplasmic translation
S101174_RS06695	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
S101174_RS06700	COG1705	Flagellar rod assembly protein muramidase FlgJ
S101174_RS06700	COG1388	LysM domain
S101174_RS06705	COG0514	ATP-dependent DNA helicase (RecQ)
S101174_RS06715	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
S101174_RS06720	COG1187	pseudouridine synthase activity
S101174_RS06725	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
S101174_RS06730	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
S101174_RS06745	COG2996	Protein conserved in bacteria
S101174_RS06760	COG0587	DNA-directed DNA polymerase activity
S101174_RS06765	COG0542	response to heat
S101174_RS06775	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
S101174_RS06780	COG2384	SAM-dependent methyltransferase
S101174_RS06785	COG1033	growth of symbiont in host cell
S101174_RS06785	COG2409	Drug exporters of the RND superfamily
S101174_RS06790	COG1959	2 iron, 2 sulfur cluster binding
S101174_RS06795	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
S101174_RS06800	COG0358	DNA primase activity
S101174_RS06805	COG0751	glycine-tRNA ligase activity
S101174_RS06810	COG0752	glycyl-tRNA synthetase alpha subunit
S101174_RS06815	COG1381	Involved in DNA repair and RecF pathway recombination
S101174_RS06820	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
S101174_RS06825	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
S101174_RS06830	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
S101174_RS06835	COG1702	phosphate starvation-inducible protein PhoH
S101174_RS06840	COG1610	YqeY-like protein
S101174_RS06845	COG1733	regulation of RNA biosynthetic process
S101174_RS06855	COG0828	Belongs to the bacterial ribosomal protein bS21 family
S101174_RS06860	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
S101174_RS06865	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
S101174_RS06870	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
S101174_RS06875	COG1682	transport, permease protein
S101174_RS06885	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
S101174_RS06890	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
S101174_RS06895	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
S101174_RS06900	COG0124	histidyl-tRNA synthetase
S101174_RS06910	COG0860	N-Acetylmuramoyl-L-alanine amidase
S101174_RS06915	COG3001	Fructosamine kinase
S101174_RS06925	COG1490	D-aminoacyl-tRNA deacylase activity
S101174_RS06930	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
S101174_RS06940	COG1385	rRNA (uridine-N3-)-methyltransferase activity
S101174_RS06945	COG2264	protein methyltransferase activity
S101174_RS06955	COG1970	mechanosensitive ion channel activity
S101174_RS06990	COG0481	GTPase activity
S101174_RS06995	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
S101174_RS07000	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
S101174_RS07005	COG1696	Membrane protein involved in D-alanine export
S101174_RS07010	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
S101174_RS07020	COG0484	heat shock protein binding
S101174_RS07025	COG0443	Heat shock 70 kDa protein
S101174_RS07030	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
S101174_RS07035	COG1420	regulation of RNA biosynthetic process
S101174_RS07040	COG0196	riboflavin kinase activity
S101174_RS07045	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
S101174_RS07050	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
S101174_RS07055	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
S101174_RS07065	COG2740	Nucleic-acid-binding protein implicated in transcription termination
S101174_RS07070	COG0195	Participates in both transcription termination and antitermination
S101174_RS07075	COG0779	Required for maturation of 30S ribosomal subunits
S101174_RS07085	COG2176	DNA-directed DNA polymerase activity
S101174_RS07090	COG0442	prolyl-tRNA aminoacylation
S101174_RS07095	COG0750	zinc metalloprotease
S101174_RS07100	COG4589	Belongs to the CDS family
S101174_RS07105	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
S101174_RS07120	COG0528	UMP kinase activity
S101174_RS07125	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
S101174_RS07130	COG0052	Belongs to the universal ribosomal protein uS2 family
S101174_RS07140	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
S101174_RS07145	COG2827	Endonuclease containing a URI domain
S101174_RS07150	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
S101174_RS07155	COG0204	Acyl-transferase
S101174_RS07160	COG1132	(ABC) transporter
S101174_RS07165	COG1132	(ABC) transporter
S101174_RS07170	COG3763	UPF0154 protein
S101174_RS07175	COG4224	UPF0291 protein
S101174_RS07180	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
S101174_RS07195	COG3425	synthase
S101174_RS07200	COG2326	polyphosphate kinase activity
S101174_RS07215	COG0105	UTP biosynthetic process
S101174_RS07240	COG1597	lipid kinase activity
S101174_RS07255	COG0589	response to stress
S101174_RS07260	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
S101174_RS07265	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
S101174_RS07265	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
S101174_RS07270	COG5416	Lipopolysaccharide assembly protein A domain
S101174_RS07275	COG1234	tRNA 3'-trailer cleavage
S101174_RS07290	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
S101174_RS07295	COG0322	excinuclease ABC activity
S101174_RS07310	COG0218	Necessary for normal cell division and for the maintenance of normal septation
S101174_RS07315	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
S101174_RS07320	COG0544	peptidyl-prolyl cis-trans isomerase activity
S101174_RS07325	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
S101174_RS07340	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
S101174_RS07345	COG0268	Binds directly to 16S ribosomal RNA
S101174_RS07350	COG1466	dna polymerase III delta subunit
S101174_RS07355	COG2333	competence protein COMEC
S101174_RS07355	COG0658	competence protein
S101174_RS07360	COG2131	deaminase
S101174_RS07365	COG1555	photosystem II stabilization
S101174_RS07365	COG1596	polysaccharide export
S101174_RS07370	COG3480	Lon protease (S16) C-terminal proteolytic domain
S101174_RS07375	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
S101174_RS07380	COG0742	ribosomal rna small subunit methyltransferase
S101174_RS07385	COG4471	UPF0298 protein
S101174_RS07390	COG0772	Belongs to the SEDS family
S101174_RS07395	COG1217	gtp-binding protein TYPA
S101174_RS07400	COG0483	inositol monophosphate 1-phosphatase activity
S101174_RS07405	COG4476	Belongs to the UPF0223 family
S101174_RS07420	COG0508	dehydrogenase complex catalyzes the overall conversion of
S101174_RS07430	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
S101174_RS07435	COG0242	peptide deformylase activity
S101174_RS07445	COG5503	Protein of unknown function (DUF1447)
S101174_RS07450	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
S101174_RS07455	COG1597	lipid kinase activity
S101174_RS07465	COG0791	NLP P60 protein
S101174_RS07465	COG1388	LysM domain
S101174_RS07475	COG0791	NLP P60 protein
S101174_RS07490	COG1609	Transcriptional regulator
S101174_RS07495	COG0667	Aldo Keto reductase
S101174_RS07500	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
S101174_RS07505	COG4166	transmembrane transport
S101174_RS07515	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
S101174_RS07520	COG0765	amino acid transport
S101174_RS07530	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
S101174_RS07535	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
S101174_RS07550	COG0482	sulfurtransferase activity
S101174_RS07560	COG1104	cysteine desulfurase activity
S101174_RS07565	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
S101174_RS07575	COG0494	nUDIX hydrolase
S101174_RS07580	COG1278	Cold shock
S101174_RS07585	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
S101174_RS07590	COG3599	regulation of cell shape
S101174_RS07605	COG1799	cell septum assembly
S101174_RS07610	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
S101174_RS07620	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
S101174_RS07625	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
S101174_RS07630	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
S101174_RS07635	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
S101174_RS07640	COG0768	penicillin binding
S101174_RS07650	COG0275	rRNA processing
S101174_RS07655	COG2001	Belongs to the MraZ family
S101174_RS07670	COG1674	ftsk spoiiie
S101174_RS07675	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
S101174_RS07685	COG0628	permease
S101174_RS07690	COG3142	Participates in the control of copper homeostasis
S101174_RS07735	COG0564	pseudouridine synthase activity
S101174_RS07740	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
S101174_RS07745	COG2357	RelA SpoT domain protein
S101174_RS07755	COG1307	EDD domain protein, DegV family
S101174_RS07770	COG0220	tRNA (guanine-N7-)-methyltransferase activity
S101174_RS07775	COG0510	thiamine kinase activity
S101174_RS07785	COG1131	(ABC) transporter
S101174_RS07790	COG0537	adenosine 5'-monophosphoramidase activity
S101174_RS07800	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
S101174_RS07810	COG4717	serine-type aminopeptidase activity
S101174_RS07815	COG0420	3'-5' exonuclease activity
S101174_RS07820	COG3679	Belongs to the UPF0342 family
S101174_RS07825	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
S101174_RS07830	COG1438	arginine binding
S101174_RS07835	COG0018	arginyl-trna synthetase
S101174_RS07850	COG4193	domain, Protein
S101174_RS07850	COG3266	domain, Protein
S101174_RS07850	COG5632	N-Acetylmuramoyl-L-alanine amidase
S101174_RS07865	COG1794	racemase activity, acting on amino acids and derivatives
S101174_RS07875	COG0367	asparagine synthase
S101174_RS07910	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
S101174_RS07915	COG2801	Transposase and inactivated derivatives
S101174_RS07930	COG0464	growth
S101174_RS08010	COG5412	phage tail tape measure protein
S101174_RS08010	COG3953	SLT domain
S101174_RS08090	COG5484	DNA packaging
S101174_RS08155	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
S101174_RS08260	COG1846	Transcriptional regulator
S101174_RS08275	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
S101174_RS08280	COG1554	hydrolase, family 65, central catalytic
S101174_RS08285	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
S101174_RS08295	COG1428	Deoxynucleoside kinase
S101174_RS08305	COG0477	Major facilitator Superfamily
S101174_RS08310	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
S101174_RS08330	COG0393	Putative heavy-metal-binding
S101174_RS08425	COG1368	sulfuric ester hydrolase activity
S101174_RS08440	COG0438	transferase activity, transferring glycosyl groups
S101174_RS08445	COG0438	transferase activity, transferring glycosyl groups
S101174_RS08450	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
S101174_RS08465	COG0542	response to heat
S101174_RS08485	COG0446	pyridine nucleotide-disulphide oxidoreductase
S101174_RS08495	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
S101174_RS08505	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
S101174_RS08515	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
S101174_RS08520	COG0628	permease
S101174_RS08525	COG3557	Belongs to the UPF0374 family
S101174_RS08540	COG2137	regulation of response to DNA damage stimulus
S101174_RS08550	COG1295	ribonuclease BN
S101174_RS08560	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
S101174_RS08565	COG0463	Glycosyl transferase, family 2
S101174_RS08570	COG2826	transposase and inactivated derivatives, IS30 family
S101174_RS08580	COG2610	gluconate transmembrane transporter activity
S101174_RS08600	COG0513	Belongs to the DEAD box helicase family
S101174_RS08625	COG1070	Carbohydrate kinase
S101174_RS08635	COG0531	amino acid
S101174_RS08640	COG0738	Major facilitator superfamily
S101174_RS08645	COG1869	D-ribose catabolic process
S101174_RS08660	COG2390	Transcriptional regulator
S101174_RS08665	COG0813	purine-nucleoside phosphorylase activity
S101174_RS08670	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
S101174_RS08675	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
S101174_RS08690	COG2365	Tyrosine phosphatase family
S101174_RS08695	COG1902	pentaerythritol trinitrate reductase activity
S101174_RS08715	COG1012	belongs to the aldehyde dehydrogenase family
S101174_RS08730	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
S101174_RS08740	COG4869	propanediol catabolic process
S101174_RS08795	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
S101174_RS08805	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
S101174_RS08810	COG1597	lipid kinase activity
S101174_RS08815	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
S101174_RS08820	COG0154	amidase activity
S101174_RS08825	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
S101174_RS08830	COG4851	CamS sex pheromone cAM373 precursor
S101174_RS08835	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
S101174_RS08845	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
S101174_RS08850	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
S101174_RS08865	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
S101174_RS08870	COG4988	ABC transporter
S101174_RS08875	COG1294	oxidase, subunit
S101174_RS08880	COG1271	oxidase subunit
S101174_RS08890	COG1088	dTDP-glucose 4,6-dehydratase activity
S101174_RS08900	COG1442	glycosyl transferase family 8
S101174_RS08920	COG1442	glycosyl transferase family 8
S101174_RS08920	COG1216	Glycosyl transferase, family 2
S101174_RS08930	COG1215	transferase activity, transferring glycosyl groups
S101174_RS08940	COG4464	protein tyrosine phosphatase activity
S101174_RS08945	COG0489	protein tyrosine kinase activity
S101174_RS08960	COG1316	TRANSCRIPTIONal
S101174_RS08965	COG0095	Lipoate-protein ligase
S101174_RS08970	COG0531	amino acid
S101174_RS08975	COG2502	aspartate--ammonia ligase
S101174_RS08980	COG0569	domain protein
S101174_RS08985	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
S101174_RS08990	COG1482	cell wall glycoprotein biosynthetic process
S101174_RS08995	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
S101174_RS09000	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
S101174_RS09005	COG0101	tRNA pseudouridine synthase activity
S101174_RS09010	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
S101174_RS09015	COG1122	ATPase activity
S101174_RS09020	COG1122	ATPase activity
S101174_RS09025	COG0203	ribosomal protein L17
S101174_RS09030	COG0202	RNA polymerase activity
S101174_RS09035	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
S101174_RS09040	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
S101174_RS09045	COG0257	Belongs to the bacterial ribosomal protein bL36 family
S101174_RS09050	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
S101174_RS09065	COG0200	Binds to the 23S rRNA
S101174_RS09070	COG1841	ribosomal large subunit assembly
S101174_RS09075	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
S101174_RS09080	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
S101174_RS09085	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
S101174_RS09090	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
S101174_RS09095	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
S101174_RS09100	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
S101174_RS09105	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
S101174_RS09110	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
S101174_RS09115	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
S101174_RS09120	COG0255	Belongs to the universal ribosomal protein uL29 family
S101174_RS09125	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
S101174_RS09130	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
S101174_RS09135	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
S101174_RS09140	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
S101174_RS09145	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
S101174_RS09150	COG0089	rRNA binding
S101174_RS09155	COG0088	Forms part of the polypeptide exit tunnel
S101174_RS09160	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
S101174_RS09165	COG0051	transcription antitermination factor activity, RNA binding
S101174_RS09175	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
S101174_RS09180	COG0049	tRNA binding
S101174_RS09185	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
S101174_RS09195	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
S101174_RS09200	COG0085	RNA polymerase activity
S101174_RS09210	COG0542	response to heat
S101174_RS09215	COG4463	regulation of RNA biosynthetic process
S101174_RS09260	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
S101174_RS09265	COG1428	Deoxynucleoside kinase
S101174_RS09270	COG0833	amino acid
S101174_RS09320	COG2814	Major facilitator Superfamily
S101174_RS09335	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
S101174_RS09360	COG0456	acetyltransferase
S101174_RS09380	COG0564	pseudouridine synthase activity
S101174_RS09395	COG0110	maltose O-acetyltransferase activity
S101174_RS09400	COG2160	L-arabinose isomerase activity
S101174_RS09425	COG0110	maltose O-acetyltransferase activity
S101174_RS09435	COG3940	Belongs to the glycosyl hydrolase 43 family
S101174_RS09450	COG0514	ATP-dependent DNA helicase (RecQ)
S101174_RS09465	COG4690	dipeptidase activity
S101174_RS09475	COG0308	aminopeptidase N
S101174_RS09480	COG1715	Restriction endonuclease
S101174_RS09495	COG0519	Catalyzes the synthesis of GMP from XMP
S101174_RS09495	COG0518	GMP synthase (glutamine-hydrolyzing) activity
S101174_RS09505	COG1072	(Pantothenic acid kinase))
S101174_RS09510	COG3973	AAA domain
S101174_RS09515	COG0475	glutathione-regulated potassium exporter activity
S101174_RS09515	COG0569	domain protein
S101174_RS09525	COG4608	Belongs to the ABC transporter superfamily
S101174_RS09530	COG0444	Belongs to the ABC transporter superfamily
S101174_RS09535	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
S101174_RS09540	COG0601	transmembrane transport
S101174_RS09545	COG4166	transmembrane transport
S101174_RS09550	COG4166	transmembrane transport
S101174_RS09555	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
S101174_RS09560	COG0765	amino acid transport
S101174_RS09565	COG0765	amino acid transport
S101174_RS09570	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
S101174_RS09575	COG1126	abc transporter atp-binding protein
S101174_RS09590	COG0735	belongs to the Fur family
S101174_RS09595	COG0194	GDP metabolic process
S101174_RS09605	COG0531	amino acid
S101174_RS09610	COG2936	dipeptidyl-peptidase activity
S101174_RS09615	COG2267	carboxylic ester hydrolase activity
S101174_RS09620	COG1376	ErfK ybiS ycfS ynhG family protein
S101174_RS09625	COG0488	(ABC) transporter
S101174_RS09645	COG4120	Belongs to the binding-protein-dependent transport system permease family
S101174_RS09655	COG1307	EDD domain protein, DegV family
S101174_RS09665	COG4120	Belongs to the binding-protein-dependent transport system permease family
S101174_RS09680	COG2084	Dehydrogenase
S101174_RS09685	COG0861	Integral membrane protein TerC family
S101174_RS09695	COG1705	Flagellar rod assembly protein muramidase FlgJ
S101174_RS09710	COG1028	Short-chain dehydrogenase reductase Sdr
S101174_RS09725	COG2814	Major facilitator Superfamily
S101174_RS09735	COG0789	Transcriptional regulator
S101174_RS09740	COG0791	NLP P60 protein
S101174_RS09740	COG3103	Sh3 type 3 domain protein
S101174_RS09740	COG1388	LysM domain
S101174_RS09750	COG0588	phosphoglycerate mutase activity
S101174_RS09755	COG1368	sulfuric ester hydrolase activity
S101174_RS09760	COG0492	ferredoxin-NADP+ reductase activity
S101174_RS09790	COG0561	phosphatase activity
S101174_RS09800	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
S101174_RS09820	COG1686	Belongs to the peptidase S11 family
S101174_RS09825	COG1686	Belongs to the peptidase S11 family
S101174_RS09835	COG4172	Belongs to the ABC transporter superfamily
S101174_RS09845	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
S101174_RS09880	COG2233	PERMEase
S101174_RS09885	COG4152	abc transporter atp-binding protein
S101174_RS09890	COG1668	transmembrane transport
S101174_RS09910	COG0656	L-ascorbic acid biosynthetic process
S101174_RS09925	COG0076	glutamate decarboxylase activity
S101174_RS09930	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
S101174_RS09935	COG3875	lactate racemase activity
S101174_RS09940	COG1691	(AIR) carboxylase
S101174_RS09945	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
S101174_RS09950	COG1606	tRNA processing
S101174_RS09955	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
S101174_RS09960	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
S101174_RS09980	COG3842	ATPase activity
S101174_RS09985	COG1176	ABC-type spermidine putrescine transport system, permease component I
S101174_RS10000	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
S101174_RS10005	COG0581	inorganic phosphate transmembrane transporter activity
S101174_RS10010	COG0573	inorganic phosphate transmembrane transporter activity
S101174_RS10050	COG1132	(ABC) transporter
S101174_RS10065	COG2706	6-phosphogluconolactonase activity
S101174_RS10075	COG0531	amino acid
S101174_RS10090	COG0735	belongs to the Fur family
S101174_RS10120	COG0589	response to stress
S101174_RS10130	COG1846	Transcriptional regulator
S101174_RS10135	COG3590	peptidase
S101174_RS10170	COG2096	Adenosyltransferase
S101174_RS10175	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
S101174_RS10190	COG1609	Transcriptional regulator
S101174_RS10195	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
S101174_RS10200	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
S101174_RS10205	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
S101174_RS10210	COG2190	(PTS) system
S101174_RS10210	COG2211	Major facilitator Superfamily
S101174_RS10220	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
S101174_RS10225	COG2017	converts alpha-aldose to the beta-anomer
S101174_RS10230	COG1960	acyl-CoA dehydrogenase activity
S101174_RS10240	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
S101174_RS10245	COG0604	alcohol dehydrogenase
S101174_RS10250	COG0640	Transcriptional regulator
S101174_RS10270	COG2814	Major facilitator Superfamily
S101174_RS10275	COG0024	Methionine aminopeptidase
S101174_RS10280	COG2226	methyltransferase
S101174_RS10290	COG2094	Belongs to the DNA glycosylase MPG family
S101174_RS10295	COG3189	MarR family transcriptional regulator
S101174_RS10300	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
S101174_RS10315	COG0110	maltose O-acetyltransferase activity
S101174_RS10325	COG0328	RNA-DNA hybrid ribonuclease activity
S101174_RS10335	COG0402	S-adenosylhomocysteine deaminase activity
S101174_RS10345	COG0351	phosphomethylpyrimidine kinase
S101174_RS10355	COG2249	NAD(P)H dehydrogenase (quinone) activity
S101174_RS10375	COG1278	Cold shock
S101174_RS10395	COG4166	transmembrane transport
S101174_RS10415	COG0509	glycine decarboxylation via glycine cleavage system
S101174_RS10420	COG0667	Aldo Keto reductase
S101174_RS10435	COG2801	Transposase and inactivated derivatives
S101174_RS10440	COG0697	spore germination
S101174_RS10445	COG2011	ABC-type metal ion transport system permease component
S101174_RS10450	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
S101174_RS10455	COG1464	Belongs to the NlpA lipoprotein family
S101174_RS10460	COG0519	Catalyzes the synthesis of GMP from XMP
S101174_RS10465	COG4166	transmembrane transport
S101174_RS10470	COG1472	Belongs to the glycosyl hydrolase 3 family
S101174_RS10475	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
S101174_RS10480	COG0419	ATPase involved in DNA repair
S101174_RS10485	COG0420	3'-5' exonuclease activity
S101174_RS10490	COG2818	Glycosylase
S101174_RS10510	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
S101174_RS10520	COG0789	Transcriptional regulator
S101174_RS10525	COG1309	transcriptional regulator
S101174_RS10545	COG2814	Major facilitator Superfamily
S101174_RS10550	COG2814	Major facilitator Superfamily
S101174_RS10555	COG1902	pentaerythritol trinitrate reductase activity
S101174_RS10560	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
S101174_RS10600	COG0163	prenyltransferase activity
S101174_RS10605	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
S101174_RS10610	COG0583	DNA-binding transcription factor activity
S101174_RS10615	COG0242	peptide deformylase activity
S101174_RS10630	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
S101174_RS10635	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
S101174_RS10640	COG1132	(ABC) transporter
S101174_RS10645	COG1846	Transcriptional regulator
S101174_RS10665	COG1131	(ABC) transporter
S101174_RS10670	COG1725	Transcriptional regulator
S101174_RS10680	COG0386	Belongs to the glutathione peroxidase family
S101174_RS10690	COG2814	Major facilitator Superfamily
S101174_RS10695	COG0561	phosphatase activity
S101174_RS10710	COG4221	oxidoreductase activity
S101174_RS10715	COG1733	regulation of RNA biosynthetic process
S101174_RS10720	COG1302	Protein conserved in bacteria
S101174_RS10725	COG1302	Protein conserved in bacteria
S101174_RS10740	COG2261	transglycosylase associated protein
S101174_RS10790	COG0436	Aminotransferase
S101174_RS10800	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
S101174_RS10805	COG2235	arginine
S101174_RS10810	COG1288	antiporter activity
S101174_RS10815	COG2205	protein histidine kinase activity
S101174_RS10820	COG0784	Response regulator, receiver
S101174_RS10825	COG1288	antiporter activity
S101174_RS10830	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
S101174_RS10855	COG2814	Major facilitator Superfamily
S101174_RS10875	COG0588	phosphoglycerate mutase activity
S101174_RS10885	COG0628	permease
S101174_RS10890	COG1940	carbohydrate kinase activity
S101174_RS10890	COG1846	Transcriptional regulator
S101174_RS10900	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
S101174_RS10905	COG2826	transposase and inactivated derivatives, IS30 family
S101174_RS10935	COG1511	domain protein
S101174_RS10935	COG1511	domain protein
S101174_RS10940	COG1686	Belongs to the peptidase S11 family
S101174_RS10955	COG0517	IMP dehydrogenase activity
S101174_RS10955	COG0516	GMP reductase activity
S101174_RS10970	COG0012	GTP binding
S101174_RS10975	COG4481	Protein conserved in bacteria
S101174_RS10980	COG1475	DNA binding
S101174_RS10985	COG1192	Involved in chromosome partitioning
S101174_RS10995	COG0357	Ribosomal RNA small subunit methyltransferase G
S101174_RS11015	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
S101174_RS11025	COG0702	epimerase
S101174_RS11075	COG2826	transposase and inactivated derivatives, IS30 family
S101174_RS11110	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
S101174_RS11160	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
S101174_RS11170	COG0352	thiamine-phosphate diphosphorylase activity
S101174_RS11175	COG0351	phosphomethylpyrimidine kinase
S101174_RS11180	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
S101174_RS11185	COG0300	oxidoreductase activity
S101174_RS11190	COG0390	transport system, permease component
S101174_RS11195	COG4619	ABC transporter
S101174_RS11200	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
S101174_RS11210	COG0789	Transcriptional regulator
S101174_RS11240	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
S101174_RS11245	COG1418	mRNA catabolic process
S101174_RS11265	COG1396	sequence-specific DNA binding
S101174_RS11280	COG1114	Component of the transport system for branched-chain amino acids
S101174_RS11290	COG0531	amino acid
S101174_RS11295	COG1114	Component of the transport system for branched-chain amino acids
S101174_RS11355	COG0582	viral genome integration into host DNA
S101174_RS11375	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
S101174_RS11395	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
S101174_RS11405	COG2244	polysaccharide biosynthetic process
S101174_RS11410	COG1476	TRANSCRIPTIONal
S101174_RS11415	COG0823	Involved in the tonB-independent uptake of proteins
S101174_RS11415	COG4946	Tricorn protease homolog
S101174_RS11415	COG1506	peptidase
S101174_RS11420	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
S101174_RS11430	COG1393	Belongs to the ArsC family
S101174_RS11435	COG0025	NhaP-type Na H and K H
S101174_RS11465	COG1609	Transcriptional regulator
S101174_RS11480	COG4475	Protein of unknown function (DUF436)
S101174_RS11490	COG0351	phosphomethylpyrimidine kinase
S101174_RS11495	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
S101174_RS11500	COG1316	TRANSCRIPTIONal
S101174_RS11520	COG0772	Belongs to the SEDS family
S101174_RS11550	COG1940	carbohydrate kinase activity
S101174_RS11565	COG2076	Multidrug Resistance protein
S101174_RS11570	COG2076	Multidrug Resistance protein
S101174_RS11610	COG4166	transmembrane transport
S101174_RS11625	COG1609	Transcriptional regulator
S101174_RS11635	COG0366	Alpha amylase catalytic
S101174_RS11655	COG1902	pentaerythritol trinitrate reductase activity
S101174_RS11665	COG1733	regulation of RNA biosynthetic process
S101174_RS11680	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
S101174_RS11710	COG1881	PFAM PEBP family protein
S101174_RS11730	COG0577	efflux transmembrane transporter activity
S101174_RS11740	COG2814	Major facilitator Superfamily
S101174_RS11745	COG2731	YhcH YjgK YiaL family protein
S101174_RS11765	COG3623	hexulose-6-phosphate isomerase
S101174_RS11770	COG1070	Carbohydrate kinase
S101174_RS11785	COG1609	Transcriptional regulator
S101174_RS11800	COG2801	Transposase and inactivated derivatives
S101174_RS11815	COG0281	malic enzyme
S101174_RS11820	COG0583	DNA-binding transcription factor activity
S101174_RS11840	COG2957	Belongs to the agmatine deiminase family
S101174_RS11845	COG0531	amino acid
S101174_RS11850	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
S101174_RS11855	COG1757	Na H antiporter
S101174_RS11860	COG0531	amino acid
S101174_RS11885	COG0183	Belongs to the thiolase family
S101174_RS11910	COG2261	transglycosylase associated protein
S101174_RS11920	COG2207	Transcriptional regulator
S101174_RS11930	COG3022	response to hydroperoxide
S101174_RS11935	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
S101174_RS11940	COG0284	orotidine-5'-phosphate decarboxylase activity
S101174_RS11945	COG2814	Major facilitator Superfamily
S101174_RS11955	COG2267	carboxylic ester hydrolase activity
S101174_RS11960	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
S101174_RS11970	COG1397	ADP-ribosylglycohydrolase
S101174_RS11975	COG2188	Transcriptional regulator
S101174_RS11980	COG4335	DNA alkylation repair
S101174_RS11995	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
S101174_RS12015	COG0110	maltose O-acetyltransferase activity
S101174_RS12055	COG2826	transposase and inactivated derivatives, IS30 family
S101174_RS12080	COG3842	ATPase activity
S101174_RS12090	COG3250	beta-galactosidase activity
S101174_RS12095	COG1959	2 iron, 2 sulfur cluster binding
S101174_RS12100	COG0702	epimerase
S101174_RS12120	COG1917	Cupin 2, conserved barrel domain protein
S101174_RS12120	COG4977	sequence-specific DNA binding
S101174_RS12130	COG1074	ATP-dependent DNA helicase activity
S101174_RS12135	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
S101174_RS12140	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
S101174_RS12145	COG0726	polysaccharide deacetylase
S101174_RS12160	COG0667	Aldo Keto reductase
S101174_RS12165	COG2252	PERMEase
S101174_RS12170	COG1846	Transcriptional regulator
S101174_RS12190	COG4485	Bacterial membrane protein, YfhO
S101174_RS12225	COG2211	Major facilitator Superfamily
S101174_RS12230	COG2207	Transcriptional regulator
S101174_RS12285	COG2814	Major facilitator Superfamily
S101174_RS12295	COG1607	acyl-coa hydrolase
S101174_RS12300	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
S101174_RS12310	COG1114	Component of the transport system for branched-chain amino acids
S101174_RS12320	COG1011	Hydrolase
S101174_RS12335	COG0445	tRNA wobble uridine modification
S101174_RS12340	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
S101174_RS12350	COG0706	membrane insertase activity
S101174_RS12355	COG0594	ribonuclease P activity
S101174_RS12360	COG0230	Belongs to the bacterial ribosomal protein bL34 family
S101174_RS12435	COG2826	transposase and inactivated derivatives, IS30 family
S101174_RS12450	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
S101174_RS12460	COG2826	transposase and inactivated derivatives, IS30 family
S101174_RS12465	COG3764	Sortase (surface protein transpeptidase)
S101174_RS12470	COG3764	Sortase (surface protein transpeptidase)
S101174_RS12540	COG2814	Major facilitator Superfamily
S101174_RS12640	COG2826	transposase and inactivated derivatives, IS30 family
S101174_RS12670	COG1131	(ABC) transporter
S101174_RS12675	COG0783	Belongs to the Dps family
S101174_RS12680	COG0640	Transcriptional regulator
S101174_RS12690	COG3118	belongs to the thioredoxin family
S101174_RS12695	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
S101174_RS12705	COG0492	ferredoxin-NADP+ reductase activity
S101174_RS12715	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
S101174_RS12765	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
S101174_RS12775	COG1192	Involved in chromosome partitioning
S101174_RS12795	COG2826	transposase and inactivated derivatives, IS30 family
S101174_RS12850	COG1302	Protein conserved in bacteria
S101174_RS12870	COG0531	amino acid
S101174_RS12915	COG1309	transcriptional regulator
S101174_RS12980	COG0783	Belongs to the Dps family
S101174_RS12995	COG2124	cytochrome p450
S101174_RS13050	COG0783	Belongs to the Dps family
S101174_RS13140	COG0783	Belongs to the Dps family
S101174_RS13185	COG0783	Belongs to the Dps family
S101174_RS13230	COG0656	L-ascorbic acid biosynthetic process
S101174_RS13255	COG0446	pyridine nucleotide-disulphide oxidoreductase