locus-tag	class	description
PX52LOC_RS00020	COG0322	excinuclease ABC activity
PX52LOC_RS00030	COG0277	FAD linked oxidase domain protein
PX52LOC_RS00050	COG1401	restriction endodeoxyribonuclease activity
PX52LOC_RS00075	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
PX52LOC_RS00085	COG5564	TIM-barrel signal transduction protein
PX52LOC_RS00120	COG0823	Involved in the tonB-independent uptake of proteins
PX52LOC_RS00120	COG1506	peptidase
PX52LOC_RS00135	COG2894	cell division
PX52LOC_RS00150	COG5002	protein histidine kinase activity
PX52LOC_RS00155	COG0573	inorganic phosphate transmembrane transporter activity
PX52LOC_RS00160	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
PX52LOC_RS00190	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
PX52LOC_RS00305	COG0509	glycine decarboxylation via glycine cleavage system
PX52LOC_RS00310	COG0404	The glycine cleavage system catalyzes the degradation of glycine
PX52LOC_RS00385	COG2755	lipolytic protein G-D-S-L family
PX52LOC_RS00385	COG0657	acetylesterase activity
PX52LOC_RS00395	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
PX52LOC_RS00400	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
PX52LOC_RS00435	COG0174	glutamine synthetase
PX52LOC_RS00485	COG1131	(ABC) transporter
PX52LOC_RS00615	COG0542	response to heat
PX52LOC_RS00625	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
PX52LOC_RS00630	COG0673	inositol 2-dehydrogenase activity
PX52LOC_RS00635	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PX52LOC_RS00640	COG3118	belongs to the thioredoxin family
PX52LOC_RS00665	COG2815	serine threonine protein kinase
PX52LOC_RS00665	COG0515	serine threonine protein kinase
PX52LOC_RS00680	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
PX52LOC_RS00690	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
PX52LOC_RS00715	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
PX52LOC_RS00745	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PX52LOC_RS00790	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
PX52LOC_RS00835	COG1191	sigma factor activity
PX52LOC_RS00840	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
PX52LOC_RS00845	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
PX52LOC_RS00850	COG1684	flagellar biosynthetic protein fliR
PX52LOC_RS00855	COG1987	bacterial-type flagellum assembly
PX52LOC_RS00865	COG1338	Plays a role in the flagellum-specific transport system
PX52LOC_RS00885	COG1157	protein secretion by the type III secretion system
PX52LOC_RS00895	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
PX52LOC_RS00905	COG1677	Flagellar hook-basal body complex protein FliE
PX52LOC_RS00915	COG1815	bacterial-type flagellum-dependent cell motility
PX52LOC_RS00925	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
PX52LOC_RS00930	COG0420	3'-5' exonuclease activity
PX52LOC_RS00935	COG0419	ATPase involved in DNA repair
PX52LOC_RS00950	COG0673	inositol 2-dehydrogenase activity
PX52LOC_RS00955	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
PX52LOC_RS00965	COG0347	Belongs to the P(II) protein family
PX52LOC_RS00990	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
PX52LOC_RS01020	COG3850	Histidine kinase
PX52LOC_RS01020	COG3437	response regulator, receiver
PX52LOC_RS01020	COG2205	protein histidine kinase activity
PX52LOC_RS01020	COG4999	Histidine kinase
PX52LOC_RS01030	COG0745	RESPONSE REGULATOR receiver
PX52LOC_RS01045	COG1301	dicarboxylic acid transport
PX52LOC_RS01050	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
PX52LOC_RS01055	COG0009	L-threonylcarbamoyladenylate synthase
PX52LOC_RS01075	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
PX52LOC_RS01080	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
PX52LOC_RS01090	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
PX52LOC_RS01125	COG0257	Belongs to the bacterial ribosomal protein bL36 family
PX52LOC_RS01130	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
PX52LOC_RS01135	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
PX52LOC_RS01140	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
PX52LOC_RS01145	COG0202	RNA polymerase activity
PX52LOC_RS01150	COG0203	ribosomal protein L17
PX52LOC_RS01170	COG0247	lactate metabolic process
PX52LOC_RS01175	COG0681	Belongs to the peptidase S26 family
PX52LOC_RS01185	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
PX52LOC_RS01190	COG2095	MarC family integral membrane protein
PX52LOC_RS01195	COG0515	serine threonine protein kinase
PX52LOC_RS01195	COG2815	serine threonine protein kinase
PX52LOC_RS01245	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PX52LOC_RS01250	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
PX52LOC_RS01260	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
PX52LOC_RS01270	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
PX52LOC_RS01285	COG5002	protein histidine kinase activity
PX52LOC_RS01290	COG2205	protein histidine kinase activity
PX52LOC_RS01335	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
PX52LOC_RS01365	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
PX52LOC_RS01375	COG3119	arylsulfatase activity
PX52LOC_RS01415	COG2815	serine threonine protein kinase
PX52LOC_RS01415	COG0515	serine threonine protein kinase
PX52LOC_RS01480	COG3258	Cytochrome c
PX52LOC_RS01535	COG2815	serine threonine protein kinase
PX52LOC_RS01535	COG0515	serine threonine protein kinase
PX52LOC_RS01545	COG3293	Transposase
PX52LOC_RS01570	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
PX52LOC_RS01605	COG0714	Associated with various cellular activities
PX52LOC_RS01620	COG3963	phosphatidate phosphatase activity
PX52LOC_RS01625	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
PX52LOC_RS01640	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PX52LOC_RS01645	COG1070	Carbohydrate kinase
PX52LOC_RS01660	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
PX52LOC_RS01670	COG2165	general secretion pathway protein
PX52LOC_RS01695	COG0556	nucleotide-excision repair
PX52LOC_RS01700	COG0284	orotidine-5'-phosphate decarboxylase activity
PX52LOC_RS01710	COG1252	NADH dehydrogenase
PX52LOC_RS01725	COG0521	Mo-molybdopterin cofactor biosynthetic process
PX52LOC_RS01730	COG0765	amino acid transport
PX52LOC_RS01735	COG1126	abc transporter atp-binding protein
PX52LOC_RS01740	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
PX52LOC_RS01765	COG0463	Glycosyl transferase, family 2
PX52LOC_RS01770	COG1028	Short-chain dehydrogenase reductase Sdr
PX52LOC_RS01775	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
PX52LOC_RS01780	COG0243	molybdopterin cofactor binding
PX52LOC_RS01790	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
PX52LOC_RS01795	COG1116	anion transmembrane transporter activity
PX52LOC_RS01800	COG1116	anion transmembrane transporter activity
PX52LOC_RS01800	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
PX52LOC_RS01810	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
PX52LOC_RS01815	COG1648	precorrin-2 dehydrogenase activity
PX52LOC_RS01815	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
PX52LOC_RS01865	COG4537	Required for transformation and DNA binding
PX52LOC_RS01920	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
PX52LOC_RS01925	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
PX52LOC_RS01935	COG0028	Belongs to the TPP enzyme family
PX52LOC_RS01940	COG2201	protein-glutamate methylesterase activity
PX52LOC_RS01970	COG2208	phosphoserine phosphatase activity
PX52LOC_RS02015	COG0297	glycogen (starch) synthase activity
PX52LOC_RS02020	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
PX52LOC_RS02030	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
PX52LOC_RS02035	COG0012	GTP binding
PX52LOC_RS02080	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
PX52LOC_RS02090	COG0513	Belongs to the DEAD box helicase family
PX52LOC_RS02095	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
PX52LOC_RS02110	COG0730	response to heat
PX52LOC_RS02130	COG1215	transferase activity, transferring glycosyl groups
PX52LOC_RS02160	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
PX52LOC_RS02180	COG1131	(ABC) transporter
PX52LOC_RS02220	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
PX52LOC_RS02235	COG1418	mRNA catabolic process
PX52LOC_RS02240	COG0457	Tetratricopeptide repeat
PX52LOC_RS02240	COG0515	serine threonine protein kinase
PX52LOC_RS02245	COG1560	Kdo2-lipid A biosynthetic process
PX52LOC_RS02250	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
PX52LOC_RS02275	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
PX52LOC_RS02315	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
PX52LOC_RS02315	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
PX52LOC_RS02325	COG2721	sulfolactate sulfo-lyase activity
PX52LOC_RS02345	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
PX52LOC_RS02350	COG0673	inositol 2-dehydrogenase activity
PX52LOC_RS02365	COG1136	(ABC) transporter
PX52LOC_RS02385	COG0515	serine threonine protein kinase
PX52LOC_RS02460	COG0514	ATP-dependent DNA helicase (RecQ)
PX52LOC_RS02465	COG0277	FAD linked oxidase domain protein
PX52LOC_RS02495	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
PX52LOC_RS02575	COG1131	(ABC) transporter
PX52LOC_RS02600	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
PX52LOC_RS02645	COG0515	serine threonine protein kinase
PX52LOC_RS02670	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
PX52LOC_RS02730	COG0643	Histidine kinase
PX52LOC_RS02730	COG0784	Response regulator, receiver
PX52LOC_RS02730	COG2198	Histidine kinase
PX52LOC_RS02735	COG0840	transmembrane signaling receptor activity
PX52LOC_RS02740	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
PX52LOC_RS02780	COG3119	arylsulfatase activity
PX52LOC_RS02800	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
PX52LOC_RS02805	COG2815	serine threonine protein kinase
PX52LOC_RS02805	COG0515	serine threonine protein kinase
PX52LOC_RS02820	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
PX52LOC_RS02830	COG0291	Belongs to the bacterial ribosomal protein bL35 family
PX52LOC_RS02835	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
PX52LOC_RS02855	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
PX52LOC_RS02860	COG1131	(ABC) transporter
PX52LOC_RS02875	COG4968	Prepilin-type N-terminal cleavage methylation domain
PX52LOC_RS02880	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
PX52LOC_RS02900	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
PX52LOC_RS02930	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
PX52LOC_RS02955	COG1262	PFAM Formylglycine-generating sulfatase enzyme
PX52LOC_RS02960	COG2515	1-aminocyclopropane-1-carboxylate deaminase
PX52LOC_RS02985	COG3781	membrane
PX52LOC_RS02995	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
PX52LOC_RS03005	COG0424	maF-like protein
PX52LOC_RS03035	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
PX52LOC_RS03065	COG1435	thymidine kinase activity
PX52LOC_RS03075	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
PX52LOC_RS03090	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
PX52LOC_RS03100	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
PX52LOC_RS03125	COG0564	pseudouridine synthase activity
PX52LOC_RS03140	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
PX52LOC_RS03145	COG2201	protein-glutamate methylesterase activity
PX52LOC_RS03150	COG0745	RESPONSE REGULATOR receiver
PX52LOC_RS03160	COG0835	chemotaxis
PX52LOC_RS03165	COG2198	Histidine kinase
PX52LOC_RS03165	COG0643	Histidine kinase
PX52LOC_RS03175	COG0745	RESPONSE REGULATOR receiver
PX52LOC_RS03215	COG4786	Flagellar basal body rod
PX52LOC_RS03230	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
PX52LOC_RS03235	COG1706	bacterial-type flagellum-dependent cell motility
PX52LOC_RS03260	COG2855	membrane
PX52LOC_RS03280	COG0109	protoheme IX farnesyltransferase activity
PX52LOC_RS03340	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
PX52LOC_RS03355	COG0515	serine threonine protein kinase
PX52LOC_RS03355	COG2815	serine threonine protein kinase
PX52LOC_RS03400	COG0202	RNA polymerase activity
PX52LOC_RS03405	COG0343	queuine tRNA-ribosyltransferase activity
PX52LOC_RS03410	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PX52LOC_RS03420	COG3876	Protein conserved in bacteria
PX52LOC_RS03425	COG0277	FAD linked oxidase domain protein
PX52LOC_RS03425	COG0247	lactate metabolic process
PX52LOC_RS03435	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
PX52LOC_RS03445	COG0113	porphobilinogen synthase activity
PX52LOC_RS03465	COG2010	Cytochrome c
PX52LOC_RS03485	COG0303	'Molybdopterin
PX52LOC_RS03490	COG2037	Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT)
PX52LOC_RS03495	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
PX52LOC_RS03515	COG0714	Associated with various cellular activities
PX52LOC_RS03565	COG5433	transposase activity
PX52LOC_RS03720	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
PX52LOC_RS03740	COG0372	Belongs to the citrate synthase family
PX52LOC_RS03770	COG0714	Associated with various cellular activities
PX52LOC_RS03795	COG0300	oxidoreductase activity
PX52LOC_RS03805	COG1595	DNA-templated transcription, initiation
PX52LOC_RS03815	COG2318	DinB family
PX52LOC_RS03840	COG0488	(ABC) transporter
PX52LOC_RS03865	COG2313	pseudouridylate synthase activity
PX52LOC_RS03880	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
PX52LOC_RS03890	COG0667	Aldo Keto reductase
PX52LOC_RS03900	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PX52LOC_RS03905	COG1082	Xylose isomerase domain protein TIM barrel
PX52LOC_RS03920	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
PX52LOC_RS03935	COG0515	serine threonine protein kinase
PX52LOC_RS03970	COG0204	Acyl-transferase
PX52LOC_RS03970	COG0318	PFAM AMP-dependent synthetase and ligase
PX52LOC_RS03975	COG3119	arylsulfatase activity
PX52LOC_RS03980	COG3119	arylsulfatase activity
PX52LOC_RS03995	COG1082	Xylose isomerase domain protein TIM barrel
PX52LOC_RS04010	COG1994	Peptidase M50
PX52LOC_RS04015	COG0267	Belongs to the bacterial ribosomal protein bL33 family
PX52LOC_RS04025	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
PX52LOC_RS04035	COG0598	Magnesium transport protein CorA
PX52LOC_RS04055	COG0166	Belongs to the GPI family
PX52LOC_RS04100	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
PX52LOC_RS04105	COG0242	peptide deformylase activity
PX52LOC_RS04130	COG5002	protein histidine kinase activity
PX52LOC_RS04140	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
PX52LOC_RS04145	COG0483	inositol monophosphate 1-phosphatase activity
PX52LOC_RS04185	COG0515	serine threonine protein kinase
PX52LOC_RS04185	COG2815	serine threonine protein kinase
PX52LOC_RS04190	COG2815	serine threonine protein kinase
PX52LOC_RS04190	COG0515	serine threonine protein kinase
PX52LOC_RS04220	COG0211	Belongs to the bacterial ribosomal protein bL27 family
PX52LOC_RS04255	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
PX52LOC_RS04325	COG0205	6-phosphofructokinase activity
PX52LOC_RS04330	COG3119	arylsulfatase activity
PX52LOC_RS04365	COG0714	Associated with various cellular activities
PX52LOC_RS04410	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PX52LOC_RS04415	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PX52LOC_RS04425	COG0450	alkyl hydroperoxide reductase
PX52LOC_RS04545	COG1595	DNA-templated transcription, initiation
PX52LOC_RS04570	COG1473	amidohydrolase
PX52LOC_RS04595	COG1566	PFAM secretion protein HlyD family protein
PX52LOC_RS04600	COG2814	Major facilitator Superfamily
PX52LOC_RS04715	COG4191	Histidine kinase
PX52LOC_RS04745	COG2815	serine threonine protein kinase
PX52LOC_RS04745	COG0515	serine threonine protein kinase
PX52LOC_RS04760	COG0523	cobalamin synthesis protein
PX52LOC_RS04765	COG0577	efflux transmembrane transporter activity
PX52LOC_RS04765	COG1136	(ABC) transporter
PX52LOC_RS04770	COG1136	(ABC) transporter
PX52LOC_RS04800	COG2801	Transposase and inactivated derivatives
PX52LOC_RS04855	COG0823	Involved in the tonB-independent uptake of proteins
PX52LOC_RS04855	COG1506	peptidase
PX52LOC_RS04870	COG0515	serine threonine protein kinase
PX52LOC_RS04885	COG2133	pyrroloquinoline quinone binding
PX52LOC_RS04940	COG1862	Preprotein translocase
PX52LOC_RS04945	COG0783	Belongs to the Dps family
PX52LOC_RS04950	COG3118	belongs to the thioredoxin family
PX52LOC_RS04970	COG0305	Participates in initiation and elongation during chromosome replication
PX52LOC_RS05005	COG1595	DNA-templated transcription, initiation
PX52LOC_RS05100	COG1484	DNA-dependent DNA replication
PX52LOC_RS05115	COG3547	Transposase (IS116 IS110 IS902 family)
PX52LOC_RS05205	COG3119	arylsulfatase activity
PX52LOC_RS05210	COG3119	arylsulfatase activity
PX52LOC_RS05215	COG3119	arylsulfatase activity
PX52LOC_RS05220	COG3119	arylsulfatase activity
PX52LOC_RS05235	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
PX52LOC_RS05240	COG0105	UTP biosynthetic process
PX52LOC_RS05265	COG0131	Imidazoleglycerol-phosphate dehydratase
PX52LOC_RS05275	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
PX52LOC_RS05300	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
PX52LOC_RS05310	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
PX52LOC_RS05315	COG0126	phosphoglycerate kinase activity
PX52LOC_RS05320	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
PX52LOC_RS05330	COG2204	response regulator
PX52LOC_RS05350	COG0306	phosphate transporter
PX52LOC_RS05355	COG1045	serine acetyltransferase
PX52LOC_RS05360	COG0538	isocitrate dehydrogenase activity
PX52LOC_RS05450	COG0657	acetylesterase activity
PX52LOC_RS05450	COG2755	lipolytic protein G-D-S-L family
PX52LOC_RS05465	COG5487	UPF0391 membrane protein
PX52LOC_RS05475	COG2852	Protein conserved in bacteria
PX52LOC_RS05495	COG0488	(ABC) transporter
PX52LOC_RS05590	COG3293	Transposase
PX52LOC_RS05705	COG0544	peptidyl-prolyl cis-trans isomerase activity
PX52LOC_RS05715	COG0463	Glycosyl transferase, family 2
PX52LOC_RS05720	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PX52LOC_RS05720	COG0072	phenylalanine-tRNA ligase activity
PX52LOC_RS05725	COG1007	ATP synthesis coupled electron transport
PX52LOC_RS05790	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
PX52LOC_RS05800	COG0596	Alpha beta hydrolase
PX52LOC_RS05815	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
PX52LOC_RS05825	COG3321	synthase
PX52LOC_RS05825	COG0604	alcohol dehydrogenase
PX52LOC_RS05825	COG3321	synthase
PX52LOC_RS05825	COG0604	alcohol dehydrogenase
PX52LOC_RS05835	COG2070	2-Nitropropane dioxygenase
PX52LOC_RS05835	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
PX52LOC_RS05845	COG0515	serine threonine protein kinase
PX52LOC_RS05870	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
PX52LOC_RS05875	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
PX52LOC_RS05875	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
PX52LOC_RS05925	COG2165	general secretion pathway protein
PX52LOC_RS05950	COG1484	DNA-dependent DNA replication
PX52LOC_RS06075	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
PX52LOC_RS06080	COG2890	protein-(glutamine-N5) methyltransferase activity
PX52LOC_RS06095	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
PX52LOC_RS06110	COG1253	flavin adenine dinucleotide binding
PX52LOC_RS06135	COG0022	dehydrogenase e1 component
PX52LOC_RS06150	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
PX52LOC_RS06175	COG0066	3-isopropylmalate dehydratase activity
PX52LOC_RS06205	COG3869	Catalyzes the specific phosphorylation of arginine residues in
PX52LOC_RS06210	COG3880	PFAM UvrB UvrC protein
PX52LOC_RS06230	COG4964	Belongs to the GSP D family
PX52LOC_RS06255	COG1620	l-lactate permease
PX52LOC_RS06275	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
PX52LOC_RS06280	COG4980	gas vesicle protein
PX52LOC_RS06280	COG1674	ftsk spoiiie
PX52LOC_RS06290	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
PX52LOC_RS06295	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
PX52LOC_RS06300	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
PX52LOC_RS06305	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
PX52LOC_RS06310	COG1028	Short-chain dehydrogenase reductase Sdr
PX52LOC_RS06315	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
PX52LOC_RS06320	COG1028	Short-chain dehydrogenase reductase Sdr
PX52LOC_RS06340	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
PX52LOC_RS06350	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
PX52LOC_RS06385	COG0534	Mate efflux family protein
PX52LOC_RS06390	COG0493	'glutamate synthase
PX52LOC_RS06390	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
PX52LOC_RS06405	COG0481	GTPase activity
PX52LOC_RS06475	COG1234	tRNA 3'-trailer cleavage
PX52LOC_RS06505	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
PX52LOC_RS06515	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
PX52LOC_RS06520	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
PX52LOC_RS06525	COG1131	(ABC) transporter
PX52LOC_RS06530	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
PX52LOC_RS06540	COG1506	peptidase
PX52LOC_RS06545	COG3876	Protein conserved in bacteria
PX52LOC_RS06550	COG0438	transferase activity, transferring glycosyl groups
PX52LOC_RS06555	COG0596	Alpha beta hydrolase
PX52LOC_RS06570	COG0673	inositol 2-dehydrogenase activity
PX52LOC_RS06605	COG1012	belongs to the aldehyde dehydrogenase family
PX52LOC_RS06615	COG4797	methyltransferase
PX52LOC_RS06615	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
PX52LOC_RS06620	COG1595	DNA-templated transcription, initiation
PX52LOC_RS06675	COG1162	GTPase activity
PX52LOC_RS06710	COG0515	serine threonine protein kinase
PX52LOC_RS06710	COG0457	Tetratricopeptide repeat
PX52LOC_RS06720	COG0302	gtp cyclohydrolase
PX52LOC_RS06725	COG0277	FAD linked oxidase domain protein
PX52LOC_RS06735	COG0314	molybdopterin synthase activity
PX52LOC_RS06740	COG0406	alpha-ribazole phosphatase activity
PX52LOC_RS06760	COG1385	rRNA (uridine-N3-)-methyltransferase activity
PX52LOC_RS06785	COG0784	Response regulator, receiver
PX52LOC_RS06785	COG3437	response regulator, receiver
PX52LOC_RS06790	COG0667	Aldo Keto reductase
PX52LOC_RS06795	COG2832	Protein of unknown function (DUF454)
PX52LOC_RS06845	COG1408	metallophosphoesterase
PX52LOC_RS06855	COG1475	DNA binding
PX52LOC_RS06865	COG1796	DNA polymerase
PX52LOC_RS06865	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
PX52LOC_RS06870	COG0436	Aminotransferase
PX52LOC_RS06885	COG1408	metallophosphoesterase
PX52LOC_RS06900	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
PX52LOC_RS06905	COG0724	RNA recognition motif
PX52LOC_RS06910	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
PX52LOC_RS06915	COG0745	RESPONSE REGULATOR receiver
PX52LOC_RS06920	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
PX52LOC_RS06935	COG1595	DNA-templated transcription, initiation
PX52LOC_RS06975	COG0187	DNA topoisomerase II activity
PX52LOC_RS06985	COG0592	DNA-directed DNA polymerase activity
PX52LOC_RS06990	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
PX52LOC_RS07000	COG3193	protein, possibly involved in utilization of glycolate and propanediol
PX52LOC_RS07005	COG1104	cysteine desulfurase activity
PX52LOC_RS07010	COG2115	Belongs to the xylose isomerase family
PX52LOC_RS07035	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
PX52LOC_RS07060	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
PX52LOC_RS07070	COG3842	ATPase activity
PX52LOC_RS07075	COG0195	Participates in both transcription termination and antitermination
PX52LOC_RS07080	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
PX52LOC_RS07080	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
PX52LOC_RS07085	COG1550	Protein conserved in bacteria
PX52LOC_RS07090	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
PX52LOC_RS07105	COG1663	tetraacyldisaccharide 4'-kinase activity
PX52LOC_RS07110	COG0859	PFAM glycosyl transferase family 9
PX52LOC_RS07125	COG0438	transferase activity, transferring glycosyl groups
PX52LOC_RS07130	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
PX52LOC_RS07155	COG2814	Major facilitator Superfamily
PX52LOC_RS07160	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
PX52LOC_RS07170	COG0519	Catalyzes the synthesis of GMP from XMP
PX52LOC_RS07170	COG0518	GMP synthase (glutamine-hydrolyzing) activity
PX52LOC_RS07200	COG2165	general secretion pathway protein
PX52LOC_RS07205	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
PX52LOC_RS07210	COG1524	type I phosphodiesterase nucleotide pyrophosphatase
PX52LOC_RS07225	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
PX52LOC_RS07235	COG3481	metal-dependent phosphohydrolase, HD sub domain
PX52LOC_RS07240	COG1216	Glycosyl transferase, family 2
PX52LOC_RS07270	COG1136	(ABC) transporter
PX52LOC_RS07280	COG0515	serine threonine protein kinase
PX52LOC_RS07280	COG2815	serine threonine protein kinase
PX52LOC_RS07295	COG1819	glycosyl
PX52LOC_RS07315	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
PX52LOC_RS07320	COG1970	mechanosensitive ion channel activity
PX52LOC_RS07335	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
PX52LOC_RS07360	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
PX52LOC_RS07370	COG0784	Response regulator, receiver
PX52LOC_RS07370	COG4191	Histidine kinase
PX52LOC_RS07385	COG4974	Belongs to the 'phage' integrase family
PX52LOC_RS07390	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
PX52LOC_RS07420	COG0475	glutathione-regulated potassium exporter activity
PX52LOC_RS07430	COG3104	oligopeptide transport
PX52LOC_RS07455	COG0673	inositol 2-dehydrogenase activity
PX52LOC_RS07495	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PX52LOC_RS07500	COG3706	GGDEF domain
PX52LOC_RS07635	COG0305	Participates in initiation and elongation during chromosome replication
PX52LOC_RS07720	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
PX52LOC_RS07725	COG1063	alcohol dehydrogenase
PX52LOC_RS07730	COG0367	asparagine synthase
PX52LOC_RS07735	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
PX52LOC_RS07745	COG0175	sulfate reduction
PX52LOC_RS07750	COG2895	sulfate adenylyltransferase (ATP) activity
PX52LOC_RS07750	COG0529	Catalyzes the synthesis of activated sulfate
PX52LOC_RS07765	COG0564	pseudouridine synthase activity
PX52LOC_RS07780	COG0802	atpase or kinase
PX52LOC_RS07785	COG1063	alcohol dehydrogenase
PX52LOC_RS07795	COG0326	Molecular chaperone. Has ATPase activity
PX52LOC_RS07800	COG0826	peptidase U32
PX52LOC_RS07875	COG0516	GMP reductase activity
PX52LOC_RS07875	COG0517	IMP dehydrogenase activity
PX52LOC_RS07890	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
PX52LOC_RS07900	COG0045	succinate-CoA ligase (ADP-forming) activity
PX52LOC_RS07910	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
PX52LOC_RS07920	COG0515	serine threonine protein kinase
PX52LOC_RS07920	COG2815	serine threonine protein kinase
PX52LOC_RS07930	COG0693	protein deglycase activity
PX52LOC_RS07950	COG0254	rRNA binding
PX52LOC_RS07955	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
PX52LOC_RS07960	COG1764	response to oxidative stress
PX52LOC_RS07965	COG5002	protein histidine kinase activity
PX52LOC_RS07970	COG0515	serine threonine protein kinase
PX52LOC_RS07975	COG1595	DNA-templated transcription, initiation
PX52LOC_RS08045	COG0180	Tryptophanyl-tRNA synthetase
PX52LOC_RS08075	COG2815	serine threonine protein kinase
PX52LOC_RS08075	COG0515	serine threonine protein kinase
PX52LOC_RS08080	COG2258	MOSC domain
PX52LOC_RS08145	COG0484	heat shock protein binding
PX52LOC_RS08150	COG3750	Belongs to the UPF0335 family
PX52LOC_RS08155	COG0629	single-stranded DNA binding
PX52LOC_RS08210	COG0640	Transcriptional regulator
PX52LOC_RS08445	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
PX52LOC_RS08485	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
PX52LOC_RS08495	COG0515	serine threonine protein kinase
PX52LOC_RS08495	COG2815	serine threonine protein kinase
PX52LOC_RS08570	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
PX52LOC_RS08585	COG0154	amidase activity
PX52LOC_RS08600	COG4974	Belongs to the 'phage' integrase family
PX52LOC_RS08655	COG0326	Molecular chaperone. Has ATPase activity
PX52LOC_RS08705	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
PX52LOC_RS08705	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
PX52LOC_RS08705	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
PX52LOC_RS08710	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
PX52LOC_RS08730	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
PX52LOC_RS08785	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
PX52LOC_RS08810	COG1530	ribonuclease E activity
PX52LOC_RS08835	COG0667	Aldo Keto reductase
PX52LOC_RS08840	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
PX52LOC_RS08860	COG0673	inositol 2-dehydrogenase activity
PX52LOC_RS08900	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
PX52LOC_RS08915	COG0438	transferase activity, transferring glycosyl groups
PX52LOC_RS08920	COG1595	DNA-templated transcription, initiation
PX52LOC_RS08935	COG0673	inositol 2-dehydrogenase activity
PX52LOC_RS08940	COG0546	phosphoglycolate phosphatase activity
PX52LOC_RS08970	COG5002	protein histidine kinase activity
PX52LOC_RS08980	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
PX52LOC_RS08990	COG0557	exoribonuclease II activity
PX52LOC_RS09010	COG5650	phosphatidylinositol metabolic process
PX52LOC_RS09025	COG0585	pseudouridine synthase activity
PX52LOC_RS09040	COG0049	tRNA binding
PX52LOC_RS09045	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
PX52LOC_RS09075	COG0540	Belongs to the ATCase OTCase family
PX52LOC_RS09200	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
PX52LOC_RS09215	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
PX52LOC_RS09250	COG3254	rhamnose metabolic process
PX52LOC_RS09260	COG4977	sequence-specific DNA binding
PX52LOC_RS09260	COG1917	Cupin 2, conserved barrel domain protein
PX52LOC_RS09280	COG4806	L-rhamnose isomerase
PX52LOC_RS09285	COG1129	ABC transporter
PX52LOC_RS09295	COG1172	Belongs to the binding-protein-dependent transport system permease family
PX52LOC_RS09300	COG1070	Carbohydrate kinase
PX52LOC_RS09375	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
PX52LOC_RS09380	COG3511	phospholipase C
PX52LOC_RS09390	COG2815	serine threonine protein kinase
PX52LOC_RS09390	COG0515	serine threonine protein kinase
PX52LOC_RS09420	COG1032	radical SAM domain protein
PX52LOC_RS09425	COG3387	PFAM Glycoside hydrolase 15-related
PX52LOC_RS09430	COG0095	Lipoate-protein ligase
PX52LOC_RS09440	COG3540	Alkaline phosphatase
PX52LOC_RS09445	COG1881	PFAM PEBP family protein
PX52LOC_RS09460	COG0714	Associated with various cellular activities
PX52LOC_RS09475	COG0539	negative regulation of cytoplasmic translation
PX52LOC_RS09505	COG0697	spore germination
PX52LOC_RS09510	COG2223	nitrite transmembrane transporter activity
PX52LOC_RS09575	COG1090	epimerase
PX52LOC_RS09660	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
PX52LOC_RS09675	COG0673	inositol 2-dehydrogenase activity
PX52LOC_RS09685	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
PX52LOC_RS09740	COG1028	Short-chain dehydrogenase reductase Sdr
PX52LOC_RS09745	COG1028	Short-chain dehydrogenase reductase Sdr
PX52LOC_RS09750	COG1695	Transcriptional regulator
PX52LOC_RS09755	COG1028	Short-chain dehydrogenase reductase Sdr
PX52LOC_RS09760	COG1028	Short-chain dehydrogenase reductase Sdr
PX52LOC_RS09765	COG0604	alcohol dehydrogenase
PX52LOC_RS09765	COG1028	Short-chain dehydrogenase reductase Sdr
PX52LOC_RS09765	COG3321	synthase
PX52LOC_RS09780	COG2382	esterase
PX52LOC_RS09780	COG3693	PFAM glycoside hydrolase, family 10
PX52LOC_RS09780	COG3507	Belongs to the glycosyl hydrolase 43 family
PX52LOC_RS09790	COG1028	Short-chain dehydrogenase reductase Sdr
PX52LOC_RS09800	COG1028	Short-chain dehydrogenase reductase Sdr
PX52LOC_RS09830	COG2271	Major facilitator Superfamily
PX52LOC_RS09875	COG0673	inositol 2-dehydrogenase activity
PX52LOC_RS09895	COG0515	serine threonine protein kinase
PX52LOC_RS09895	COG2815	serine threonine protein kinase
PX52LOC_RS09900	COG0515	serine threonine protein kinase
PX52LOC_RS09900	COG2815	serine threonine protein kinase
PX52LOC_RS09910	COG0714	Associated with various cellular activities
PX52LOC_RS09960	COG1733	regulation of RNA biosynthetic process
PX52LOC_RS09965	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
PX52LOC_RS10000	COG1484	DNA-dependent DNA replication
PX52LOC_RS10090	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
PX52LOC_RS10095	COG0318	PFAM AMP-dependent synthetase and ligase
PX52LOC_RS10100	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PX52LOC_RS10105	COG1819	glycosyl
PX52LOC_RS10110	COG0515	serine threonine protein kinase
PX52LOC_RS10110	COG2815	serine threonine protein kinase
PX52LOC_RS10130	COG0439	Biotin carboxylase
PX52LOC_RS10135	COG0511	ligase activity, forming carbon-carbon bonds
PX52LOC_RS10140	COG0006	proline dipeptidase activity
PX52LOC_RS10145	COG1648	precorrin-2 dehydrogenase activity
PX52LOC_RS10145	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
PX52LOC_RS10155	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
PX52LOC_RS10175	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
PX52LOC_RS10190	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
PX52LOC_RS10195	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
PX52LOC_RS10200	COG0081	regulation of translation
PX52LOC_RS10210	COG0222	ribosome binding
PX52LOC_RS10215	COG2814	Major facilitator Superfamily
PX52LOC_RS10240	COG2815	serine threonine protein kinase
PX52LOC_RS10240	COG0515	serine threonine protein kinase
PX52LOC_RS10265	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
PX52LOC_RS10320	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
PX52LOC_RS10330	COG3119	arylsulfatase activity
PX52LOC_RS10335	COG4941	Belongs to the sigma-70 factor family
PX52LOC_RS10340	COG3795	YCII-related domain
PX52LOC_RS10360	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
PX52LOC_RS10365	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
PX52LOC_RS10370	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
PX52LOC_RS10380	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
PX52LOC_RS10385	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
PX52LOC_RS10395	COG0617	tRNA 3'-terminal CCA addition
PX52LOC_RS10410	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PX52LOC_RS10420	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
PX52LOC_RS10430	COG0024	Methionine aminopeptidase
PX52LOC_RS10435	COG0563	adenylate kinase activity
PX52LOC_RS10455	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
PX52LOC_RS10460	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
PX52LOC_RS10465	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
PX52LOC_RS10470	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
PX52LOC_RS10475	COG0159	tryptophan synthase activity
PX52LOC_RS10495	COG2766	serine protein kinase
PX52LOC_RS10500	COG1181	Belongs to the D-alanine--D-alanine ligase family
PX52LOC_RS10505	COG1073	alpha beta
PX52LOC_RS10520	COG0515	serine threonine protein kinase
PX52LOC_RS10540	COG0204	Acyl-transferase
PX52LOC_RS10540	COG0318	PFAM AMP-dependent synthetase and ligase
PX52LOC_RS10550	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
PX52LOC_RS10555	COG2088	sporulation resulting in formation of a cellular spore
PX52LOC_RS10560	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
PX52LOC_RS10565	COG0196	riboflavin kinase activity
PX52LOC_RS10590	COG2815	serine threonine protein kinase
PX52LOC_RS10590	COG0515	serine threonine protein kinase
PX52LOC_RS10635	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PX52LOC_RS10650	COG0545	Peptidyl-prolyl cis-trans isomerase
PX52LOC_RS10695	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
PX52LOC_RS10700	COG1657	PFAM Prenyltransferase squalene oxidase
PX52LOC_RS10715	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
PX52LOC_RS10725	COG0515	serine threonine protein kinase
PX52LOC_RS10725	COG2815	serine threonine protein kinase
PX52LOC_RS10740	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
PX52LOC_RS10745	COG0193	aminoacyl-tRNA hydrolase activity
PX52LOC_RS10750	COG0360	Binds together with S18 to 16S ribosomal RNA
PX52LOC_RS10755	COG0629	single-stranded DNA binding
PX52LOC_RS10760	COG0359	binds to the 23S rRNA
PX52LOC_RS10765	COG0305	Participates in initiation and elongation during chromosome replication
PX52LOC_RS10770	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
PX52LOC_RS10780	COG0215	cysteine-tRNA ligase activity
PX52LOC_RS10785	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
PX52LOC_RS10790	COG0632	four-way junction helicase activity
PX52LOC_RS10810	COG2255	four-way junction helicase activity
PX52LOC_RS10815	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
PX52LOC_RS10845	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
PX52LOC_RS10855	COG0823	Involved in the tonB-independent uptake of proteins
PX52LOC_RS10890	COG0673	inositol 2-dehydrogenase activity
PX52LOC_RS10900	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
PX52LOC_RS10910	COG2304	oxidoreductase activity
PX52LOC_RS10920	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
PX52LOC_RS10930	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
PX52LOC_RS10935	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
PX52LOC_RS10960	COG4208	sulfate ABC transporter
PX52LOC_RS10965	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
PX52LOC_RS10990	COG4303	Ethanolamine ammonia lyase large subunit
PX52LOC_RS10995	COG0531	amino acid
PX52LOC_RS11000	COG4302	ethanolamine ammonia-lyase activity
PX52LOC_RS11005	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
PX52LOC_RS11010	COG5002	protein histidine kinase activity
PX52LOC_RS11015	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
PX52LOC_RS11015	COG0758	DNA mediated transformation
PX52LOC_RS11050	COG0488	(ABC) transporter
PX52LOC_RS11065	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
PX52LOC_RS11070	COG1131	(ABC) transporter
PX52LOC_RS11130	COG2815	serine threonine protein kinase
PX52LOC_RS11130	COG0515	serine threonine protein kinase
PX52LOC_RS11165	COG0495	leucyl-tRNA aminoacylation
PX52LOC_RS11180	COG0347	Belongs to the P(II) protein family
PX52LOC_RS11185	COG4191	Histidine kinase
PX52LOC_RS11215	COG0437	4 iron, 4 sulfur cluster binding
PX52LOC_RS11250	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
PX52LOC_RS11280	COG0109	protoheme IX farnesyltransferase activity
PX52LOC_RS11285	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
PX52LOC_RS11375	COG0745	RESPONSE REGULATOR receiver
PX52LOC_RS11410	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
PX52LOC_RS11430	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PX52LOC_RS11435	COG1999	signal sequence binding
PX52LOC_RS11440	COG1611	Belongs to the LOG family
PX52LOC_RS11450	COG0408	coproporphyrinogen oxidase activity
PX52LOC_RS11465	COG0789	Transcriptional regulator
PX52LOC_RS11470	COG2319	Wd-40 repeat
PX52LOC_RS11485	COG0745	RESPONSE REGULATOR receiver
PX52LOC_RS11495	COG2165	general secretion pathway protein
PX52LOC_RS11510	COG1131	(ABC) transporter
PX52LOC_RS11515	COG0183	Belongs to the thiolase family
PX52LOC_RS11535	COG0463	Glycosyl transferase, family 2
PX52LOC_RS11545	COG2195	Cleaves the N-terminal amino acid of tripeptides
PX52LOC_RS11550	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
PX52LOC_RS11555	COG0110	maltose O-acetyltransferase activity
PX52LOC_RS11590	COG0438	transferase activity, transferring glycosyl groups
PX52LOC_RS11595	COG0463	Glycosyl transferase, family 2
PX52LOC_RS11635	COG1459	type II secretion system
PX52LOC_RS11650	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
PX52LOC_RS11710	COG2169	Transcriptional regulator
PX52LOC_RS11710	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
PX52LOC_RS11830	COG1595	DNA-templated transcription, initiation
PX52LOC_RS11910	COG1733	regulation of RNA biosynthetic process
PX52LOC_RS11955	COG0515	serine threonine protein kinase
PX52LOC_RS11955	COG2815	serine threonine protein kinase
PX52LOC_RS11960	COG1199	ATP-dependent helicase activity
PX52LOC_RS11965	COG2205	protein histidine kinase activity
PX52LOC_RS12005	COG1918	ferrous iron import across plasma membrane
PX52LOC_RS12005	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
PX52LOC_RS12010	COG1918	ferrous iron import across plasma membrane
PX52LOC_RS12010	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
PX52LOC_RS12050	COG1129	ABC transporter
PX52LOC_RS12050	COG0842	Transport permease protein
PX52LOC_RS12160	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
PX52LOC_RS12180	COG3754	Rhamnan synthesis protein F
PX52LOC_RS12185	COG1215	transferase activity, transferring glycosyl groups
PX52LOC_RS12190	COG1216	Glycosyl transferase, family 2
PX52LOC_RS12195	COG1216	Glycosyl transferase, family 2
PX52LOC_RS12230	COG1215	transferase activity, transferring glycosyl groups
PX52LOC_RS12255	COG0438	transferase activity, transferring glycosyl groups
PX52LOC_RS12265	COG2165	general secretion pathway protein
PX52LOC_RS12285	COG2205	protein histidine kinase activity
PX52LOC_RS12285	COG0784	Response regulator, receiver
PX52LOC_RS12295	COG4251	negative regulation of phosphorylation
PX52LOC_RS12300	COG0784	Response regulator, receiver
PX52LOC_RS12340	COG4372	Transposase
PX52LOC_RS12505	COG0745	RESPONSE REGULATOR receiver
PX52LOC_RS12510	COG0745	RESPONSE REGULATOR receiver
PX52LOC_RS12550	COG0305	Participates in initiation and elongation during chromosome replication
PX52LOC_RS12625	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
PX52LOC_RS12640	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
PX52LOC_RS12650	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
PX52LOC_RS12660	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
PX52LOC_RS12665	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
PX52LOC_RS12675	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
PX52LOC_RS12680	COG3511	phospholipase C
PX52LOC_RS12710	COG0315	cyclic pyranopterin monophosphate synthase activity
PX52LOC_RS12715	COG0142	geranyltranstransferase activity
PX52LOC_RS12720	COG1793	dna ligase
PX52LOC_RS12725	COG1012	belongs to the aldehyde dehydrogenase family
PX52LOC_RS12750	COG1051	belongs to the nudix hydrolase family
PX52LOC_RS12750	COG1056	cytidyltransferase-related domain
PX52LOC_RS12755	COG1335	isochorismatase
PX52LOC_RS12765	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PX52LOC_RS12815	COG0612	Peptidase, M16
PX52LOC_RS12820	COG0456	acetyltransferase
PX52LOC_RS12830	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
PX52LOC_RS12845	COG3386	PFAM SMP-30 Gluconolaconase
PX52LOC_RS12905	COG0515	serine threonine protein kinase
PX52LOC_RS12925	COG0667	Aldo Keto reductase
PX52LOC_RS12940	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
PX52LOC_RS12955	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
PX52LOC_RS12970	COG3119	arylsulfatase activity
PX52LOC_RS12990	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
PX52LOC_RS13015	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
PX52LOC_RS13030	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
PX52LOC_RS13055	COG0602	queuosine metabolic process
PX52LOC_RS13065	COG1132	(ABC) transporter
PX52LOC_RS13080	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
PX52LOC_RS13090	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
PX52LOC_RS13105	COG1196	nuclear chromosome segregation
PX52LOC_RS13120	COG0463	Glycosyl transferase, family 2
PX52LOC_RS13140	COG2813	Specifically methylates the guanine in position
PX52LOC_RS13145	COG0515	serine threonine protein kinase
PX52LOC_RS13145	COG2815	serine threonine protein kinase
PX52LOC_RS13175	COG0824	Thioesterase
PX52LOC_RS13210	COG3706	GGDEF domain
PX52LOC_RS13220	COG0405	Gamma-glutamyltransferase
PX52LOC_RS13240	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
PX52LOC_RS13265	COG2755	lipolytic protein G-D-S-L family
PX52LOC_RS13275	COG3401	FG-GAP repeat protein
PX52LOC_RS13280	COG3119	arylsulfatase activity
PX52LOC_RS13310	COG3501	Rhs element vgr protein
PX52LOC_RS13330	COG1490	D-aminoacyl-tRNA deacylase activity
PX52LOC_RS13360	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
PX52LOC_RS13395	COG1064	alcohol dehydrogenase
PX52LOC_RS13400	COG3604	Transcriptional regulator
PX52LOC_RS13410	COG0667	Aldo Keto reductase
PX52LOC_RS13435	COG5433	transposase activity
PX52LOC_RS13470	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
PX52LOC_RS13485	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
PX52LOC_RS13490	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
PX52LOC_RS13510	COG0175	sulfate reduction
PX52LOC_RS13525	COG1446	asparaginase
PX52LOC_RS13560	COG1028	Short-chain dehydrogenase reductase Sdr
PX52LOC_RS13575	COG0727	PFAM Uncharacterised protein family (UPF0153)
PX52LOC_RS13580	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
PX52LOC_RS13615	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
PX52LOC_RS13620	COG3252	Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT
PX52LOC_RS13625	COG0189	ligase activity
PX52LOC_RS13635	COG4636	protein conserved in cyanobacteria
PX52LOC_RS13640	COG0720	synthase
PX52LOC_RS13650	COG0517	IMP dehydrogenase activity
PX52LOC_RS13655	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
PX52LOC_RS13660	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
PX52LOC_RS13665	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
PX52LOC_RS13670	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
PX52LOC_RS13680	COG2226	methyltransferase
PX52LOC_RS13685	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
PX52LOC_RS13690	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
PX52LOC_RS13730	COG1668	transmembrane transport
PX52LOC_RS13740	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
PX52LOC_RS13945	COG0442	prolyl-tRNA aminoacylation
PX52LOC_RS14025	COG1595	DNA-templated transcription, initiation
PX52LOC_RS14045	COG3746	phosphate-selective porin O and P
PX52LOC_RS14055	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
PX52LOC_RS14095	COG0052	Belongs to the universal ribosomal protein uS2 family
PX52LOC_RS14100	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
PX52LOC_RS14105	COG0268	Binds directly to 16S ribosomal RNA
PX52LOC_RS14125	COG2755	lipolytic protein G-D-S-L family
PX52LOC_RS14125	COG0657	acetylesterase activity
PX52LOC_RS14130	COG0673	inositol 2-dehydrogenase activity
PX52LOC_RS14145	COG3293	Transposase
PX52LOC_RS14155	COG1012	belongs to the aldehyde dehydrogenase family
PX52LOC_RS14165	COG0805	protein transport
PX52LOC_RS14175	COG0673	inositol 2-dehydrogenase activity
PX52LOC_RS14185	COG2226	methyltransferase
PX52LOC_RS14200	COG1331	Highly conserved protein containing a thioredoxin domain
PX52LOC_RS14210	COG1250	3-hydroxyacyl-CoA dehydrogenase
PX52LOC_RS14210	COG1024	Enoyl-CoA hydratase
PX52LOC_RS14220	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
PX52LOC_RS14250	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
PX52LOC_RS14305	COG2304	oxidoreductase activity
PX52LOC_RS14345	COG1397	ADP-ribosylglycohydrolase
PX52LOC_RS14390	COG0165	Argininosuccinate lyase
PX52LOC_RS14430	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
PX52LOC_RS14440	COG0261	This protein binds to 23S rRNA in the presence of protein L20
PX52LOC_RS14460	COG0640	Transcriptional regulator
PX52LOC_RS14470	COG1028	Short-chain dehydrogenase reductase Sdr
PX52LOC_RS14520	COG1595	DNA-templated transcription, initiation
PX52LOC_RS14535	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
PX52LOC_RS14560	COG4106	trans-aconitate 2-methyltransferase activity
PX52LOC_RS14575	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
PX52LOC_RS14585	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
PX52LOC_RS14595	COG1722	exodeoxyribonuclease VII activity
PX52LOC_RS14605	COG0095	Lipoate-protein ligase
PX52LOC_RS14610	COG2718	Belongs to the UPF0229 family
PX52LOC_RS14615	COG2719	SpoVR family
PX52LOC_RS14635	COG2226	methyltransferase
PX52LOC_RS14640	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
PX52LOC_RS14645	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
PX52LOC_RS14690	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
PX52LOC_RS14700	COG3119	arylsulfatase activity
PX52LOC_RS14735	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
PX52LOC_RS14740	COG0484	heat shock protein binding
PX52LOC_RS14750	COG0459	protein refolding
PX52LOC_RS14755	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
PX52LOC_RS14760	COG0459	protein refolding
PX52LOC_RS14775	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
PX52LOC_RS14805	COG2815	serine threonine protein kinase
PX52LOC_RS14805	COG0515	serine threonine protein kinase
PX52LOC_RS14845	COG2084	Dehydrogenase
PX52LOC_RS14850	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
PX52LOC_RS14875	COG0516	GMP reductase activity
PX52LOC_RS14875	COG0517	IMP dehydrogenase activity
PX52LOC_RS14885	COG3119	arylsulfatase activity
PX52LOC_RS14900	COG1595	DNA-templated transcription, initiation
PX52LOC_RS14910	COG0698	ribose 5-phosphate isomerase
PX52LOC_RS14925	COG0085	RNA polymerase activity
PX52LOC_RS14930	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
PX52LOC_RS14940	COG0515	serine threonine protein kinase
PX52LOC_RS14940	COG2815	serine threonine protein kinase
PX52LOC_RS14945	COG1505	serine-type exopeptidase activity
PX52LOC_RS14970	COG2189	Belongs to the N(4) N(6)-methyltransferase family
PX52LOC_RS14990	COG0577	efflux transmembrane transporter activity
PX52LOC_RS14990	COG1136	(ABC) transporter
PX52LOC_RS15010	COG3119	arylsulfatase activity
PX52LOC_RS15015	COG3119	arylsulfatase activity
PX52LOC_RS15035	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
PX52LOC_RS15035	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
PX52LOC_RS15045	COG2815	serine threonine protein kinase
PX52LOC_RS15045	COG0515	serine threonine protein kinase
PX52LOC_RS15085	COG0347	Belongs to the P(II) protein family
PX52LOC_RS15100	COG0275	rRNA processing
PX52LOC_RS15110	COG0673	inositol 2-dehydrogenase activity
PX52LOC_RS15125	COG0515	serine threonine protein kinase
PX52LOC_RS15125	COG2815	serine threonine protein kinase
PX52LOC_RS15175	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
PX52LOC_RS15180	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
PX52LOC_RS15195	COG1181	Belongs to the D-alanine--D-alanine ligase family
PX52LOC_RS15210	COG0443	Heat shock 70 kDa protein
PX52LOC_RS15230	COG1401	restriction endodeoxyribonuclease activity
PX52LOC_RS15250	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
PX52LOC_RS15255	COG0326	Molecular chaperone. Has ATPase activity
PX52LOC_RS15260	COG1686	Belongs to the peptidase S11 family
PX52LOC_RS15290	COG1774	PSP1 C-terminal conserved region
PX52LOC_RS15295	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
PX52LOC_RS15305	COG3422	double-strand break repair
PX52LOC_RS15320	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
PX52LOC_RS15335	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
PX52LOC_RS15390	COG0515	serine threonine protein kinase
PX52LOC_RS15395	COG1966	Carbon starvation protein
PX52LOC_RS15400	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
PX52LOC_RS15455	COG2226	methyltransferase
PX52LOC_RS15465	COG2226	methyltransferase
PX52LOC_RS15525	COG2226	methyltransferase
PX52LOC_RS15540	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
PX52LOC_RS15595	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
PX52LOC_RS15600	COG1309	transcriptional regulator
PX52LOC_RS15605	COG1028	Short-chain dehydrogenase reductase Sdr
PX52LOC_RS15620	COG2205	protein histidine kinase activity
PX52LOC_RS15620	COG3850	Histidine kinase
PX52LOC_RS15620	COG4999	Histidine kinase
PX52LOC_RS15620	COG3437	response regulator, receiver
PX52LOC_RS15625	COG5002	protein histidine kinase activity
PX52LOC_RS15635	COG2382	esterase
PX52LOC_RS15635	COG3507	Belongs to the glycosyl hydrolase 43 family
PX52LOC_RS15635	COG3693	PFAM glycoside hydrolase, family 10
PX52LOC_RS15645	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
PX52LOC_RS15650	COG0784	Response regulator, receiver
PX52LOC_RS15650	COG2205	protein histidine kinase activity
PX52LOC_RS15705	COG2815	serine threonine protein kinase
PX52LOC_RS15705	COG0515	serine threonine protein kinase
PX52LOC_RS15745	COG0515	serine threonine protein kinase
PX52LOC_RS15755	COG1262	PFAM Formylglycine-generating sulfatase enzyme
PX52LOC_RS15755	COG0515	serine threonine protein kinase
PX52LOC_RS15770	COG0515	serine threonine protein kinase
PX52LOC_RS15785	COG4968	Prepilin-type N-terminal cleavage methylation domain
PX52LOC_RS15810	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
PX52LOC_RS15835	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
PX52LOC_RS15845	COG1297	OPT oligopeptide transporter protein
PX52LOC_RS15850	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
PX52LOC_RS15860	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
PX52LOC_RS15870	COG1482	cell wall glycoprotein biosynthetic process
PX52LOC_RS15890	COG2183	response to ionizing radiation
PX52LOC_RS16040	COG0488	(ABC) transporter
PX52LOC_RS16060	COG2815	serine threonine protein kinase
PX52LOC_RS16060	COG0515	serine threonine protein kinase
PX52LOC_RS16070	COG2373	Large extracellular alpha-helical protein
PX52LOC_RS16080	COG5433	transposase activity
PX52LOC_RS16100	COG1484	DNA-dependent DNA replication
PX52LOC_RS16145	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
PX52LOC_RS16150	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PX52LOC_RS16155	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
PX52LOC_RS16160	COG1116	anion transmembrane transporter activity
PX52LOC_RS16170	COG1959	2 iron, 2 sulfur cluster binding
PX52LOC_RS16185	COG3119	arylsulfatase activity
PX52LOC_RS16245	COG1942	4-Oxalocrotonate Tautomerase
PX52LOC_RS16340	COG2815	serine threonine protein kinase
PX52LOC_RS16340	COG0515	serine threonine protein kinase
PX52LOC_RS16365	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
PX52LOC_RS16385	COG2070	2-Nitropropane dioxygenase
PX52LOC_RS16390	COG1942	4-Oxalocrotonate Tautomerase
PX52LOC_RS16395	COG1028	Short-chain dehydrogenase reductase Sdr
PX52LOC_RS16400	COG1764	response to oxidative stress
PX52LOC_RS16415	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PX52LOC_RS16435	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
PX52LOC_RS16440	COG1185	polyribonucleotide nucleotidyltransferase activity
PX52LOC_RS16455	COG2815	serine threonine protein kinase
PX52LOC_RS16455	COG0515	serine threonine protein kinase
PX52LOC_RS16465	COG0596	Alpha beta hydrolase
PX52LOC_RS16490	COG2205	protein histidine kinase activity
PX52LOC_RS16500	COG2755	lipolytic protein G-D-S-L family
PX52LOC_RS16550	COG2514	catechol 2,3-dioxygenase activity
PX52LOC_RS16555	COG4106	trans-aconitate 2-methyltransferase activity
PX52LOC_RS16565	COG4762	Protein conserved in bacteria
PX52LOC_RS16570	COG0702	epimerase
PX52LOC_RS16575	COG4106	trans-aconitate 2-methyltransferase activity
PX52LOC_RS16655	COG2124	cytochrome p450
PX52LOC_RS16665	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PX52LOC_RS16770	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
PX52LOC_RS16805	COG5002	protein histidine kinase activity
PX52LOC_RS16810	COG4251	negative regulation of phosphorylation
PX52LOC_RS16815	COG2204	response regulator
PX52LOC_RS16825	COG5487	UPF0391 membrane protein
PX52LOC_RS16840	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
PX52LOC_RS16845	COG1760	l-serine dehydratase
PX52LOC_RS16855	COG0628	permease
PX52LOC_RS16860	COG0635	Involved in the biosynthesis of porphyrin-containing compound
PX52LOC_RS16865	COG0509	glycine decarboxylation via glycine cleavage system
PX52LOC_RS16895	COG0142	geranyltranstransferase activity
PX52LOC_RS16920	COG1752	Esterase of the alpha-beta hydrolase superfamily
PX52LOC_RS16930	COG4191	Histidine kinase
PX52LOC_RS16950	COG1064	alcohol dehydrogenase
PX52LOC_RS16965	COG0456	acetyltransferase
PX52LOC_RS17005	COG0515	serine threonine protein kinase
PX52LOC_RS17005	COG2815	serine threonine protein kinase
PX52LOC_RS17030	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
PX52LOC_RS17035	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PX52LOC_RS17040	COG2815	serine threonine protein kinase
PX52LOC_RS17040	COG0515	serine threonine protein kinase
PX52LOC_RS17055	COG1233	COG1233 Phytoene dehydrogenase and related
PX52LOC_RS17075	COG1355	regulation of microtubule-based process
PX52LOC_RS17095	COG2815	serine threonine protein kinase
PX52LOC_RS17095	COG0515	serine threonine protein kinase
PX52LOC_RS17100	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
PX52LOC_RS17110	COG1555	photosystem II stabilization
PX52LOC_RS17115	COG1131	(ABC) transporter
PX52LOC_RS17180	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
PX52LOC_RS17180	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
PX52LOC_RS17290	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
PX52LOC_RS17300	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
PX52LOC_RS17305	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
PX52LOC_RS17310	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
PX52LOC_RS17315	COG3590	peptidase
PX52LOC_RS17335	COG0861	Integral membrane protein TerC family
PX52LOC_RS17340	COG1131	(ABC) transporter
PX52LOC_RS17355	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
PX52LOC_RS17380	COG4191	Histidine kinase
PX52LOC_RS17385	COG2204	response regulator
PX52LOC_RS17390	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
PX52LOC_RS17425	COG2226	methyltransferase
PX52LOC_RS17435	COG1136	(ABC) transporter
PX52LOC_RS17435	COG0577	efflux transmembrane transporter activity
PX52LOC_RS17445	COG0473	3-isopropylmalate dehydrogenase activity
PX52LOC_RS17500	COG0443	Heat shock 70 kDa protein
PX52LOC_RS17505	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
PX52LOC_RS17515	COG0626	cystathionine gamma-synthase activity
PX52LOC_RS17545	COG2198	Histidine kinase
PX52LOC_RS17545	COG0643	Histidine kinase
PX52LOC_RS17565	COG0517	IMP dehydrogenase activity
PX52LOC_RS17565	COG1125	glycine betaine transport
PX52LOC_RS17575	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
PX52LOC_RS17580	COG1262	PFAM Formylglycine-generating sulfatase enzyme
PX52LOC_RS17590	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
PX52LOC_RS17595	COG3604	Transcriptional regulator
PX52LOC_RS17615	COG2204	response regulator
PX52LOC_RS17685	COG3293	Transposase
PX52LOC_RS17760	COG2815	serine threonine protein kinase
PX52LOC_RS17760	COG0515	serine threonine protein kinase
PX52LOC_RS17770	COG2202	Pas domain
PX52LOC_RS17770	COG2205	protein histidine kinase activity
PX52LOC_RS17795	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
PX52LOC_RS17815	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
PX52LOC_RS17820	COG2207	Transcriptional regulator
PX52LOC_RS17830	COG0668	transmembrane transport
PX52LOC_RS17845	COG0517	IMP dehydrogenase activity
PX52LOC_RS17845	COG0516	GMP reductase activity
PX52LOC_RS17895	COG4372	Transposase
PX52LOC_RS17930	COG0515	serine threonine protein kinase
PX52LOC_RS17930	COG2815	serine threonine protein kinase
PX52LOC_RS18025	COG2897	thiosulfate sulfurtransferase activity
PX52LOC_RS18070	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
PX52LOC_RS18075	COG0589	response to stress
PX52LOC_RS18085	COG0589	response to stress
PX52LOC_RS18090	COG0517	IMP dehydrogenase activity
PX52LOC_RS18090	COG0516	GMP reductase activity
PX52LOC_RS18110	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
PX52LOC_RS18115	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
PX52LOC_RS18120	COG0058	SHG alpha-glucan phosphorylase activity
PX52LOC_RS18145	COG2203	Gaf domain
PX52LOC_RS18145	COG3706	GGDEF domain
PX52LOC_RS18145	COG5001	Diguanylate cyclase
PX52LOC_RS18145	COG4251	negative regulation of phosphorylation
PX52LOC_RS18150	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
PX52LOC_RS18190	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PX52LOC_RS18195	COG4191	Histidine kinase
PX52LOC_RS18435	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
PX52LOC_RS18440	COG0557	exoribonuclease II activity
PX52LOC_RS18455	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
PX52LOC_RS18465	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
PX52LOC_RS18480	COG4585	Histidine kinase
PX52LOC_RS18525	COG0443	Heat shock 70 kDa protein
PX52LOC_RS18535	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
PX52LOC_RS18540	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
PX52LOC_RS18550	COG2801	Transposase and inactivated derivatives
PX52LOC_RS18590	COG4251	negative regulation of phosphorylation
PX52LOC_RS18595	COG0784	Response regulator, receiver
PX52LOC_RS18600	COG0784	Response regulator, receiver
PX52LOC_RS18600	COG4191	Histidine kinase
PX52LOC_RS18625	COG0489	protein tyrosine kinase activity
PX52LOC_RS18630	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
PX52LOC_RS18640	COG4191	Histidine kinase
PX52LOC_RS18640	COG0784	Response regulator, receiver
PX52LOC_RS18645	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
PX52LOC_RS18655	COG0745	RESPONSE REGULATOR receiver
PX52LOC_RS18660	COG3293	Transposase
PX52LOC_RS18705	COG2801	Transposase and inactivated derivatives
PX52LOC_RS18830	COG1234	tRNA 3'-trailer cleavage
PX52LOC_RS18840	COG1058	Belongs to the CinA family
PX52LOC_RS18840	COG1546	Belongs to the CinA family
PX52LOC_RS18845	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
PX52LOC_RS18850	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
PX52LOC_RS18860	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PX52LOC_RS18865	COG0649	NAD binding
PX52LOC_RS18895	COG0811	peptide transport
PX52LOC_RS18910	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
PX52LOC_RS18920	COG2081	HI0933 family
PX52LOC_RS18925	COG0484	heat shock protein binding
PX52LOC_RS18930	COG0594	ribonuclease P activity
PX52LOC_RS18935	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
PX52LOC_RS18945	COG0750	zinc metalloprotease
PX52LOC_RS18965	COG0084	hydrolase, TatD family'
PX52LOC_RS19185	COG0706	membrane insertase activity
PX52LOC_RS19190	COG0693	protein deglycase activity
PX52LOC_RS19195	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PX52LOC_RS19195	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PX52LOC_RS19200	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
PX52LOC_RS19240	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
PX52LOC_RS19240	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
PX52LOC_RS19270	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
PX52LOC_RS19285	COG1136	(ABC) transporter
PX52LOC_RS19295	COG0824	Thioesterase
PX52LOC_RS19310	COG2271	Major facilitator Superfamily
PX52LOC_RS19355	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
PX52LOC_RS19365	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
PX52LOC_RS19365	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
PX52LOC_RS19380	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
PX52LOC_RS19420	COG0352	thiamine-phosphate diphosphorylase activity
PX52LOC_RS19435	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
PX52LOC_RS19440	COG0187	DNA topoisomerase II activity
PX52LOC_RS19445	COG1725	Transcriptional regulator
PX52LOC_RS19450	COG1131	(ABC) transporter
PX52LOC_RS19515	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
PX52LOC_RS19535	COG1007	ATP synthesis coupled electron transport
PX52LOC_RS19545	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
PX52LOC_RS19550	COG0713	ATP synthesis coupled electron transport
PX52LOC_RS19555	COG0839	Belongs to the complex I subunit 6 family
PX52LOC_RS19560	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PX52LOC_RS19565	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
PX52LOC_RS19575	COG1034	ATP synthesis coupled electron transport
PX52LOC_RS19590	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
PX52LOC_RS19600	COG0649	NAD binding
PX52LOC_RS19605	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PX52LOC_RS19610	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PX52LOC_RS19615	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PX52LOC_RS19625	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
PX52LOC_RS19635	COG0713	ATP synthesis coupled electron transport
PX52LOC_RS19660	COG0355	proton-transporting ATP synthase activity, rotational mechanism
PX52LOC_RS19665	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
PX52LOC_RS19680	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
PX52LOC_RS19685	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
PX52LOC_RS19705	COG0356	it plays a direct role in the translocation of protons across the membrane
PX52LOC_RS19720	COG0501	Belongs to the peptidase M48B family
PX52LOC_RS19735	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
PX52LOC_RS19740	COG1012	belongs to the aldehyde dehydrogenase family
PX52LOC_RS19810	COG0489	protein tyrosine kinase activity
PX52LOC_RS19840	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
PX52LOC_RS19845	COG0358	DNA primase activity
PX52LOC_RS19855	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
PX52LOC_RS19925	COG0070	glutamate synthase
PX52LOC_RS19925	COG0069	glutamate synthase activity
PX52LOC_RS19925	COG0067	glutamate synthase
PX52LOC_RS19945	COG0515	serine threonine protein kinase
PX52LOC_RS19945	COG2815	serine threonine protein kinase
PX52LOC_RS19970	COG2304	oxidoreductase activity
PX52LOC_RS20060	COG1573	uracil-dna glycosylase
PX52LOC_RS20090	COG2226	methyltransferase
PX52LOC_RS20090	COG2867	negative regulation of translational initiation
PX52LOC_RS20105	COG2268	Band 7 protein
PX52LOC_RS20120	COG1621	beta-fructofuranosidase activity
PX52LOC_RS20135	COG1879	ABC-type sugar transport system periplasmic component
PX52LOC_RS20140	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PX52LOC_RS20160	COG0438	transferase activity, transferring glycosyl groups
PX52LOC_RS20315	COG4712	double-strand break repair protein
PX52LOC_RS20320	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
PX52LOC_RS20330	COG1215	transferase activity, transferring glycosyl groups
PX52LOC_RS20340	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PX52LOC_RS20365	COG0515	serine threonine protein kinase
PX52LOC_RS20365	COG2815	serine threonine protein kinase
PX52LOC_RS20375	COG1846	Transcriptional regulator
PX52LOC_RS20375	COG1940	carbohydrate kinase activity
PX52LOC_RS20395	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
PX52LOC_RS20400	COG0515	serine threonine protein kinase
PX52LOC_RS20400	COG2815	serine threonine protein kinase
PX52LOC_RS20415	COG0778	Nitroreductase
PX52LOC_RS20420	COG0745	RESPONSE REGULATOR receiver
PX52LOC_RS20435	COG0571	ribonuclease III activity
PX52LOC_RS20445	COG0275	rRNA processing
PX52LOC_RS20455	COG1285	pathogenesis
PX52LOC_RS20470	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
PX52LOC_RS20475	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
PX52LOC_RS20480	COG0811	peptide transport
PX52LOC_RS20500	COG0443	Heat shock 70 kDa protein
PX52LOC_RS20505	COG0077	Prephenate dehydratase
PX52LOC_RS20505	COG1605	Chorismate mutase
PX52LOC_RS20520	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PX52LOC_RS20525	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
PX52LOC_RS20555	COG0438	transferase activity, transferring glycosyl groups
PX52LOC_RS20565	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
PX52LOC_RS20575	COG0489	protein tyrosine kinase activity
PX52LOC_RS20605	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PX52LOC_RS20655	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
PX52LOC_RS20670	COG0673	inositol 2-dehydrogenase activity
PX52LOC_RS20675	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
PX52LOC_RS20690	COG3684	Belongs to the aldolase LacD family
PX52LOC_RS20700	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
PX52LOC_RS20700	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
PX52LOC_RS20710	COG1758	RNA polymerase activity
PX52LOC_RS20715	COG0194	GDP metabolic process
PX52LOC_RS20720	COG1561	YicC-like family, N-terminal region
PX52LOC_RS20730	COG0149	triose-phosphate isomerase activity
PX52LOC_RS20735	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
PX52LOC_RS20765	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
PX52LOC_RS20780	COG0023	Translation Initiation Factor
PX52LOC_RS20800	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
PX52LOC_RS20815	COG1136	(ABC) transporter
PX52LOC_RS20815	COG0577	efflux transmembrane transporter activity
PX52LOC_RS20825	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
PX52LOC_RS20865	COG0363	glucosamine-6-phosphate deaminase activity
PX52LOC_RS20880	COG1172	Belongs to the binding-protein-dependent transport system permease family
PX52LOC_RS20930	COG0574	Belongs to the PEP-utilizing enzyme family
PX52LOC_RS20930	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
PX52LOC_RS20945	COG1082	Xylose isomerase domain protein TIM barrel
PX52LOC_RS20950	COG1063	alcohol dehydrogenase
PX52LOC_RS20975	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
PX52LOC_RS20990	COG0674	pyruvate-flavodoxin oxidoreductase activity
PX52LOC_RS20990	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
PX52LOC_RS20995	COG1013	pyruvate-flavodoxin oxidoreductase activity
PX52LOC_RS21015	COG3250	beta-galactosidase activity
PX52LOC_RS21060	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
PX52LOC_RS21080	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
PX52LOC_RS21110	COG0823	Involved in the tonB-independent uptake of proteins
PX52LOC_RS21130	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
PX52LOC_RS21150	COG0163	prenyltransferase activity
PX52LOC_RS21175	COG1191	sigma factor activity
PX52LOC_RS21185	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
PX52LOC_RS21195	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
PX52LOC_RS21220	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
PX52LOC_RS21250	COG1164	Oligoendopeptidase f
PX52LOC_RS21265	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
PX52LOC_RS21290	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
PX52LOC_RS21300	COG1984	allophanate hydrolase subunit 2
PX52LOC_RS21320	COG0492	ferredoxin-NADP+ reductase activity
PX52LOC_RS21355	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
PX52LOC_RS21395	COG0210	DNA helicase
PX52LOC_RS21815	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
PX52LOC_RS21840	COG1834	amidinotransferase
PX52LOC_RS21855	COG3604	Transcriptional regulator
PX52LOC_RS21865	COG3059	membrane
PX52LOC_RS21895	COG2770	Histidine kinase
PX52LOC_RS21895	COG2208	phosphoserine phosphatase activity
PX52LOC_RS21910	COG2204	response regulator
PX52LOC_RS21915	COG3852	Histidine kinase
PX52LOC_RS21925	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
PX52LOC_RS21945	COG0477	Major facilitator Superfamily
PX52LOC_RS21980	COG4191	Histidine kinase
PX52LOC_RS21985	COG2204	response regulator
PX52LOC_RS22000	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
PX52LOC_RS22340	COG0640	Transcriptional regulator
PX52LOC_RS22475	COG3685	Protein conserved in bacteria
PX52LOC_RS22480	COG0028	Belongs to the TPP enzyme family
PX52LOC_RS22485	COG0300	oxidoreductase activity
PX52LOC_RS22500	COG2197	response regulator
PX52LOC_RS22505	COG4585	Histidine kinase
PX52LOC_RS22515	COG0753	catalase activity
PX52LOC_RS22525	COG0546	phosphoglycolate phosphatase activity
PX52LOC_RS22530	COG0673	inositol 2-dehydrogenase activity
PX52LOC_RS22655	COG0745	RESPONSE REGULATOR receiver
PX52LOC_RS22785	COG1595	DNA-templated transcription, initiation
PX52LOC_RS22860	COG1132	(ABC) transporter
PX52LOC_RS22870	COG0515	serine threonine protein kinase
PX52LOC_RS22915	COG2198	Histidine kinase
PX52LOC_RS22915	COG0784	Response regulator, receiver
PX52LOC_RS22915	COG2205	protein histidine kinase activity
PX52LOC_RS23025	COG0305	Participates in initiation and elongation during chromosome replication
PX52LOC_RS23060	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
PX52LOC_RS23080	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
PX52LOC_RS23085	COG5002	protein histidine kinase activity
PX52LOC_RS23100	COG2205	protein histidine kinase activity
PX52LOC_RS23100	COG0784	Response regulator, receiver
PX52LOC_RS23130	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
PX52LOC_RS23155	COG2205	protein histidine kinase activity
PX52LOC_RS23155	COG0784	Response regulator, receiver
PX52LOC_RS23155	COG2198	Histidine kinase
PX52LOC_RS23165	COG2205	protein histidine kinase activity
PX52LOC_RS23170	COG2204	response regulator
PX52LOC_RS23185	COG1595	DNA-templated transcription, initiation
PX52LOC_RS23190	COG2706	6-phosphogluconolactonase activity
PX52LOC_RS23205	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
PX52LOC_RS23340	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
PX52LOC_RS23340	COG1672	PFAM Archaeal ATPase
PX52LOC_RS23345	COG1285	pathogenesis
PX52LOC_RS23360	COG0515	serine threonine protein kinase
PX52LOC_RS23375	COG0515	serine threonine protein kinase
PX52LOC_RS23375	COG2815	serine threonine protein kinase
PX52LOC_RS23390	COG2813	Specifically methylates the guanine in position
PX52LOC_RS23395	COG4106	trans-aconitate 2-methyltransferase activity
PX52LOC_RS23445	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
PX52LOC_RS23495	COG5002	protein histidine kinase activity
PX52LOC_RS23510	COG0784	Response regulator, receiver
PX52LOC_RS23510	COG4191	Histidine kinase
PX52LOC_RS23550	COG1902	pentaerythritol trinitrate reductase activity
PX52LOC_RS23585	COG1201	RNA secondary structure unwinding
PX52LOC_RS23650	COG0346	lactoylglutathione lyase activity
PX52LOC_RS23745	COG2255	four-way junction helicase activity
PX52LOC_RS23805	COG1191	sigma factor activity
PX52LOC_RS23810	COG0515	serine threonine protein kinase
PX52LOC_RS23810	COG2815	serine threonine protein kinase
PX52LOC_RS23830	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
PX52LOC_RS23850	COG0673	inositol 2-dehydrogenase activity
PX52LOC_RS23860	COG0585	pseudouridine synthase activity
PX52LOC_RS23870	COG1082	Xylose isomerase domain protein TIM barrel
PX52LOC_RS23875	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PX52LOC_RS23880	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
PX52LOC_RS23885	COG2226	methyltransferase
PX52LOC_RS23890	COG0006	proline dipeptidase activity
PX52LOC_RS23905	COG0129	dihydroxy-acid dehydratase activity
PX52LOC_RS23915	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
PX52LOC_RS23920	COG0156	8-amino-7-oxononanoate synthase activity
PX52LOC_RS23925	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
PX52LOC_RS23965	COG2814	Major facilitator Superfamily
PX52LOC_RS23980	COG0386	Belongs to the glutathione peroxidase family
PX52LOC_RS24005	COG2308	Evidence 4 Homologs of previously reported genes of
PX52LOC_RS24030	COG1899	peptidyl-lysine modification to peptidyl-hypusine
PX52LOC_RS24055	COG0579	oxidoreductase
PX52LOC_RS24065	COG0463	Glycosyl transferase, family 2
PX52LOC_RS24065	COG0457	Tetratricopeptide repeat
PX52LOC_RS24130	COG0531	amino acid
PX52LOC_RS24135	COG5285	phytanoyl-CoA dioxygenase
PX52LOC_RS24280	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
PX52LOC_RS24315	COG0635	Involved in the biosynthesis of porphyrin-containing compound
PX52LOC_RS24365	COG2211	Major facilitator Superfamily
PX52LOC_RS24375	COG2205	protein histidine kinase activity
PX52LOC_RS24390	COG1606	tRNA processing
PX52LOC_RS24400	COG1136	(ABC) transporter
PX52LOC_RS24490	COG0484	heat shock protein binding
PX52LOC_RS24505	COG0443	Heat shock 70 kDa protein
PX52LOC_RS24510	COG2819	hydrolase of the alpha beta superfamily
PX52LOC_RS24565	COG2814	Major facilitator Superfamily
PX52LOC_RS24580	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
PX52LOC_RS24595	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
PX52LOC_RS24600	COG1131	(ABC) transporter
PX52LOC_RS24610	COG0420	3'-5' exonuclease activity
PX52LOC_RS24615	COG0419	ATPase involved in DNA repair
PX52LOC_RS24630	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
PX52LOC_RS24635	COG0529	Catalyzes the synthesis of activated sulfate
PX52LOC_RS24675	COG1214	PFAM Peptidase M22, glycoprotease
PX52LOC_RS24685	COG0574	Belongs to the PEP-utilizing enzyme family
PX52LOC_RS24685	COG3848	Pyruvate phosphate dikinase
PX52LOC_RS24700	COG2815	serine threonine protein kinase
PX52LOC_RS24700	COG0515	serine threonine protein kinase
PX52LOC_RS24725	COG5002	protein histidine kinase activity
PX52LOC_RS24725	COG5001	Diguanylate cyclase
PX52LOC_RS24730	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
PX52LOC_RS24740	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PX52LOC_RS24745	COG1193	negative regulation of DNA recombination
PX52LOC_RS24750	COG0310	cobalt ion transport
PX52LOC_RS24780	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
PX52LOC_RS24785	COG1321	iron dependent repressor
PX52LOC_RS24790	COG0107	imidazoleglycerol-phosphate synthase activity
PX52LOC_RS24805	COG0443	Heat shock 70 kDa protein
PX52LOC_RS24810	COG2975	iron-sulfur cluster assembly
PX52LOC_RS24830	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
PX52LOC_RS24835	COG2815	serine threonine protein kinase
PX52LOC_RS24835	COG0515	serine threonine protein kinase
PX52LOC_RS24845	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
PX52LOC_RS24850	COG0803	Belongs to the bacterial solute-binding protein 9 family
PX52LOC_RS24855	COG1121	(ABC) transporter
PX52LOC_RS24860	COG1473	amidohydrolase
PX52LOC_RS24880	COG0659	secondary active sulfate transmembrane transporter activity
PX52LOC_RS24885	COG2204	response regulator
PX52LOC_RS24890	COG4191	Histidine kinase
PX52LOC_RS24915	COG2897	thiosulfate sulfurtransferase activity
PX52LOC_RS24935	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
PX52LOC_RS24940	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
PX52LOC_RS24945	COG1573	uracil-dna glycosylase
PX52LOC_RS24950	COG2815	serine threonine protein kinase
PX52LOC_RS24950	COG0515	serine threonine protein kinase
PX52LOC_RS24975	COG0440	acetolactate synthase activity
PX52LOC_RS24995	COG1309	transcriptional regulator
PX52LOC_RS25005	COG1136	(ABC) transporter
PX52LOC_RS25015	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
PX52LOC_RS25025	COG0724	RNA recognition motif
PX52LOC_RS25035	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
PX52LOC_RS25045	COG0404	The glycine cleavage system catalyzes the degradation of glycine
PX52LOC_RS25080	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
PX52LOC_RS25085	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
PX52LOC_RS25090	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
PX52LOC_RS25095	COG0525	valine-tRNA ligase activity
PX52LOC_RS25105	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
PX52LOC_RS25110	COG0151	Belongs to the GarS family
PX52LOC_RS25125	COG3132	Protein of unknown function, DUF480
PX52LOC_RS25155	COG0489	protein tyrosine kinase activity
PX52LOC_RS25165	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
PX52LOC_RS25170	COG1030	water channel activity
PX52LOC_RS25175	COG1030	water channel activity
PX52LOC_RS25180	COG4864	UPF0365 protein
PX52LOC_RS25200	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
PX52LOC_RS25210	COG0335	large ribosomal subunit rRNA binding
PX52LOC_RS25215	COG0336	Belongs to the RNA methyltransferase TrmD family
PX52LOC_RS25220	COG0228	four-way junction DNA binding
PX52LOC_RS25230	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
PX52LOC_RS25275	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PX52LOC_RS25280	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
PX52LOC_RS25300	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
PX52LOC_RS25310	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
PX52LOC_RS25355	COG0612	Peptidase, M16
PX52LOC_RS25360	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
PX52LOC_RS25370	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
PX52LOC_RS25375	COG0423	glycine-tRNA ligase activity
PX52LOC_RS25385	COG0025	NhaP-type Na H and K H
PX52LOC_RS25425	COG0318	PFAM AMP-dependent synthetase and ligase
PX52LOC_RS25425	COG0204	Acyl-transferase
PX52LOC_RS25455	COG2815	serine threonine protein kinase
PX52LOC_RS25455	COG0515	serine threonine protein kinase
PX52LOC_RS25485	COG4232	protein-disulfide reductase activity
PX52LOC_RS25500	COG4946	Tricorn protease homolog
PX52LOC_RS25500	COG0823	Involved in the tonB-independent uptake of proteins
PX52LOC_RS25500	COG1506	peptidase
PX52LOC_RS25510	COG0714	Associated with various cellular activities
PX52LOC_RS25550	COG1403	HNH endonuclease
PX52LOC_RS25575	COG0047	phosphoribosylformylglycinamidine synthase activity
PX52LOC_RS25590	COG0736	holo-[acyl-carrier-protein] synthase activity
PX52LOC_RS25615	COG0745	RESPONSE REGULATOR receiver
PX52LOC_RS25620	COG1408	metallophosphoesterase
PX52LOC_RS25630	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
PX52LOC_RS25635	COG0287	Prephenate dehydrogenase
PX52LOC_RS25640	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
PX52LOC_RS25660	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
PX52LOC_RS25665	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
PX52LOC_RS25670	COG0310	cobalt ion transport
PX52LOC_RS25675	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
PX52LOC_RS25685	COG1122	ATPase activity
PX52LOC_RS25700	COG1492	cobalamin metabolic process
PX52LOC_RS25710	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
PX52LOC_RS25720	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
PX52LOC_RS25745	COG2165	general secretion pathway protein
PX52LOC_RS25755	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
PX52LOC_RS25780	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
PX52LOC_RS25785	COG2815	serine threonine protein kinase
PX52LOC_RS25785	COG0515	serine threonine protein kinase
PX52LOC_RS25795	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
PX52LOC_RS25800	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
PX52LOC_RS25820	COG0714	Associated with various cellular activities
PX52LOC_RS25880	COG0297	glycogen (starch) synthase activity
PX52LOC_RS25885	COG0438	transferase activity, transferring glycosyl groups
PX52LOC_RS25890	COG1957	nucleoside hydrolase
PX52LOC_RS25895	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
PX52LOC_RS25900	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
PX52LOC_RS26020	COG4397	Mu-like prophage major head subunit gpT
PX52LOC_RS26185	COG0305	Participates in initiation and elongation during chromosome replication
PX52LOC_RS26215	COG3293	Transposase
PX52LOC_RS26225	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
PX52LOC_RS26230	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
PX52LOC_RS26235	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
PX52LOC_RS26245	COG1607	acyl-coa hydrolase
PX52LOC_RS26260	COG0515	serine threonine protein kinase
PX52LOC_RS26260	COG2815	serine threonine protein kinase
PX52LOC_RS26275	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
PX52LOC_RS26300	COG2207	Transcriptional regulator
PX52LOC_RS26355	COG0463	Glycosyl transferase, family 2
PX52LOC_RS26395	COG0438	transferase activity, transferring glycosyl groups
PX52LOC_RS26400	COG1215	transferase activity, transferring glycosyl groups
PX52LOC_RS26420	COG2165	general secretion pathway protein
PX52LOC_RS26460	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
PX52LOC_RS26470	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PX52LOC_RS26485	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
PX52LOC_RS26565	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
PX52LOC_RS26575	COG2304	oxidoreductase activity
PX52LOC_RS26580	COG0473	3-isopropylmalate dehydrogenase activity
PX52LOC_RS26585	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
PX52LOC_RS26605	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
PX52LOC_RS26620	COG0473	3-isopropylmalate dehydrogenase activity
PX52LOC_RS26635	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
PX52LOC_RS26650	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
PX52LOC_RS26670	COG0745	RESPONSE REGULATOR receiver
PX52LOC_RS26675	COG0445	tRNA wobble uridine modification
PX52LOC_RS26680	COG0673	inositol 2-dehydrogenase activity
PX52LOC_RS26690	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
PX52LOC_RS26715	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
PX52LOC_RS26720	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
PX52LOC_RS26725	COG4589	Belongs to the CDS family
PX52LOC_RS26730	COG1702	phosphate starvation-inducible protein PhoH
PX52LOC_RS26745	COG0300	oxidoreductase activity
PX52LOC_RS26750	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
PX52LOC_RS26755	COG0742	ribosomal rna small subunit methyltransferase
PX52LOC_RS26760	COG0527	aspartate kinase activity
PX52LOC_RS26770	COG0745	RESPONSE REGULATOR receiver
PX52LOC_RS26775	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
PX52LOC_RS26795	COG1132	(ABC) transporter
PX52LOC_RS26805	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
PX52LOC_RS26810	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
PX52LOC_RS26825	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
PX52LOC_RS26830	COG2226	methyltransferase
PX52LOC_RS26840	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
PX52LOC_RS26875	COG1477	protein flavinylation
PX52LOC_RS26890	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
PX52LOC_RS26910	COG0825	malonyl-CoA metabolic process
PX52LOC_RS26915	COG0515	serine threonine protein kinase
PX52LOC_RS26915	COG2815	serine threonine protein kinase
PX52LOC_RS26930	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
PX52LOC_RS26945	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
PX52LOC_RS26955	COG0180	Tryptophanyl-tRNA synthetase
PX52LOC_RS26965	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
PX52LOC_RS26970	COG1073	alpha beta
PX52LOC_RS27250	COG4372	Transposase
PX52LOC_RS27260	COG3676	manually curated
PX52LOC_RS27280	COG3963	phosphatidate phosphatase activity
PX52LOC_RS27285	COG0688	phosphatidylethanolamine metabolic process
PX52LOC_RS27345	COG0515	serine threonine protein kinase
PX52LOC_RS27350	COG0515	serine threonine protein kinase
PX52LOC_RS27350	COG2815	serine threonine protein kinase
PX52LOC_RS27360	COG3979	chitinase
PX52LOC_RS27455	COG4974	Belongs to the 'phage' integrase family
PX52LOC_RS27480	COG0515	serine threonine protein kinase
PX52LOC_RS27490	COG3293	Transposase
PX52LOC_RS27530	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
PX52LOC_RS27680	COG0640	Transcriptional regulator
PX52LOC_RS27760	COG0475	glutathione-regulated potassium exporter activity
PX52LOC_RS27765	COG0515	serine threonine protein kinase
PX52LOC_RS27765	COG2815	serine threonine protein kinase
PX52LOC_RS27800	COG0679	Auxin Efflux Carrier
PX52LOC_RS27835	COG0596	Alpha beta hydrolase
PX52LOC_RS27840	COG5002	protein histidine kinase activity
PX52LOC_RS27885	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
PX52LOC_RS27890	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
PX52LOC_RS27915	COG1301	dicarboxylic acid transport
PX52LOC_RS28120	COG3728	DNA packaging
PX52LOC_RS28120	COG5484	DNA packaging
PX52LOC_RS28180	COG0629	single-stranded DNA binding
PX52LOC_RS28185	COG3750	Belongs to the UPF0335 family
PX52LOC_RS28305	COG1475	DNA binding
PX52LOC_RS28375	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
PX52LOC_RS28385	COG0497	DNA recombination
PX52LOC_RS28415	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
PX52LOC_RS28485	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
PX52LOC_RS28490	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
PX52LOC_RS28490	COG0662	Cupin 2, conserved barrel domain protein
PX52LOC_RS28495	COG4284	Utp--glucose-1-phosphate uridylyltransferase
PX52LOC_RS28500	COG0321	lipoyl(octanoyl) transferase activity
PX52LOC_RS28500	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
PX52LOC_RS28515	COG4974	Belongs to the 'phage' integrase family
PX52LOC_RS28530	COG0542	response to heat
PX52LOC_RS28535	COG0673	inositol 2-dehydrogenase activity
PX52LOC_RS28550	COG0564	pseudouridine synthase activity
PX52LOC_RS28555	COG0745	RESPONSE REGULATOR receiver
PX52LOC_RS28560	COG5002	protein histidine kinase activity
PX52LOC_RS28570	COG1216	Glycosyl transferase, family 2
PX52LOC_RS28570	COG0438	transferase activity, transferring glycosyl groups
PX52LOC_RS28575	COG1262	PFAM Formylglycine-generating sulfatase enzyme
PX52LOC_RS28580	COG2010	Cytochrome c
PX52LOC_RS28585	COG0742	ribosomal rna small subunit methyltransferase
PX52LOC_RS28590	COG1119	ATPase activity
PX52LOC_RS28630	COG4974	Belongs to the 'phage' integrase family
PX52LOC_RS28850	COG3676	manually curated
PX52LOC_RS28855	COG0412	Dienelactone hydrolase
PX52LOC_RS28860	COG4977	sequence-specific DNA binding
PX52LOC_RS28895	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
PX52LOC_RS29005	COG3293	Transposase
PX52LOC_RS29100	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
PX52LOC_RS29110	COG4235	cytochrome complex assembly
PX52LOC_RS29120	COG0803	Belongs to the bacterial solute-binding protein 9 family
PX52LOC_RS29125	COG1121	(ABC) transporter
PX52LOC_RS29140	COG1621	beta-fructofuranosidase activity
PX52LOC_RS29160	COG0457	Tetratricopeptide repeat
PX52LOC_RS29160	COG0515	serine threonine protein kinase
PX52LOC_RS29165	COG0724	RNA recognition motif
PX52LOC_RS29190	COG0438	transferase activity, transferring glycosyl groups
PX52LOC_RS29195	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
PX52LOC_RS29210	COG0124	histidyl-tRNA synthetase
PX52LOC_RS29225	COG1921	L-seryl-tRNASec selenium transferase activity
PX52LOC_RS29235	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
PX52LOC_RS29260	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
PX52LOC_RS29270	COG4555	ABC transporter
PX52LOC_RS29315	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
PX52LOC_RS29320	COG0492	ferredoxin-NADP+ reductase activity
PX52LOC_RS29325	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
PX52LOC_RS29330	COG0799	negative regulation of ribosome biogenesis
PX52LOC_RS29335	COG0018	arginyl-trna synthetase
PX52LOC_RS29340	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
PX52LOC_RS29345	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
PX52LOC_RS29350	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
PX52LOC_RS29370	COG0820	rRNA (adenine-C2-)-methyltransferase activity
PX52LOC_RS29375	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
PX52LOC_RS29380	COG0508	dehydrogenase complex catalyzes the overall conversion of
PX52LOC_RS29395	COG0137	argininosuccinate synthase activity
PX52LOC_RS29415	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
PX52LOC_RS29420	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
PX52LOC_RS29425	COG0438	transferase activity, transferring glycosyl groups
PX52LOC_RS29430	COG0631	protein serine/threonine phosphatase activity
PX52LOC_RS29445	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
PX52LOC_RS29465	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
PX52LOC_RS29470	COG0504	CTP synthase activity
PX52LOC_RS29500	COG3293	Transposase
PX52LOC_RS29610	COG2815	serine threonine protein kinase
PX52LOC_RS29610	COG0515	serine threonine protein kinase
PX52LOC_RS29625	COG0812	UDP-N-acetylmuramate dehydrogenase activity
PX52LOC_RS29635	COG1024	Enoyl-CoA hydratase
PX52LOC_RS29635	COG1250	3-hydroxyacyl-CoA dehydrogenase
PX52LOC_RS29645	COG0463	Glycosyl transferase, family 2
PX52LOC_RS29660	COG0653	protein targeting
PX52LOC_RS29690	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
PX52LOC_RS29710	COG1524	type I phosphodiesterase nucleotide pyrophosphatase
PX52LOC_RS29715	COG1643	Atp-dependent helicase
PX52LOC_RS29745	COG1381	Involved in DNA repair and RecF pathway recombination
PX52LOC_RS29750	COG0259	pyridoxamine-phosphate oxidase activity
PX52LOC_RS29755	COG0386	Belongs to the glutathione peroxidase family
PX52LOC_RS29760	COG0714	Associated with various cellular activities
PX52LOC_RS29790	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PX52LOC_RS29970	COG2211	Major facilitator Superfamily
PX52LOC_RS29990	COG1063	alcohol dehydrogenase
PX52LOC_RS30005	COG2706	6-phosphogluconolactonase activity
PX52LOC_RS30015	COG0714	Associated with various cellular activities
PX52LOC_RS30030	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
PX52LOC_RS30035	COG0508	dehydrogenase complex catalyzes the overall conversion of
PX52LOC_RS30040	COG0167	dihydroorotate dehydrogenase activity
PX52LOC_RS30045	COG1028	Short-chain dehydrogenase reductase Sdr
PX52LOC_RS30055	COG0667	Aldo Keto reductase
PX52LOC_RS30110	COG0432	Pfam Uncharacterised protein family UPF0047
PX52LOC_RS30120	COG2258	MOSC domain
PX52LOC_RS30195	COG0640	Transcriptional regulator
PX52LOC_RS30200	COG2267	carboxylic ester hydrolase activity
PX52LOC_RS30375	COG3693	PFAM glycoside hydrolase, family 10
PX52LOC_RS30375	COG2382	esterase
PX52LOC_RS30375	COG3507	Belongs to the glycosyl hydrolase 43 family
PX52LOC_RS30405	COG5433	transposase activity
PX52LOC_RS30495	COG0640	Transcriptional regulator
PX52LOC_RS30550	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
PX52LOC_RS30630	COG2205	protein histidine kinase activity
PX52LOC_RS30630	COG2198	Histidine kinase
PX52LOC_RS30630	COG0784	Response regulator, receiver
PX52LOC_RS30765	COG3940	Belongs to the glycosyl hydrolase 43 family
PX52LOC_RS30865	COG0305	Participates in initiation and elongation during chromosome replication
PX52LOC_RS31015	COG0515	serine threonine protein kinase
PX52LOC_RS31040	COG0629	single-stranded DNA binding
PX52LOC_RS31115	COG3728	DNA packaging
PX52LOC_RS31285	COG5433	transposase activity
PX52LOC_RS31330	COG0590	tRNA wobble adenosine to inosine editing
PX52LOC_RS31370	COG3459	Glycosyltransferase 36 associated
PX52LOC_RS31380	COG1132	(ABC) transporter
PX52LOC_RS31415	COG1940	carbohydrate kinase activity
PX52LOC_RS31420	COG0135	phosphoribosylanthranilate isomerase activity
PX52LOC_RS31425	COG1940	carbohydrate kinase activity
PX52LOC_RS31430	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
PX52LOC_RS31460	COG2208	phosphoserine phosphatase activity
PX52LOC_RS31460	COG2770	Histidine kinase
PX52LOC_RS31550	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
PX52LOC_RS31555	COG0316	Belongs to the HesB IscA family
PX52LOC_RS31610	COG2205	protein histidine kinase activity
PX52LOC_RS31650	COG3501	Rhs element vgr protein
PX52LOC_RS31755	COG0515	serine threonine protein kinase
PX52LOC_RS31755	COG1262	PFAM Formylglycine-generating sulfatase enzyme
PX52LOC_RS31790	COG0745	RESPONSE REGULATOR receiver
PX52LOC_RS31795	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
PX52LOC_RS31810	COG3119	arylsulfatase activity
PX52LOC_RS31825	COG0745	RESPONSE REGULATOR receiver
PX52LOC_RS31905	COG4282	regulation of fungal-type cell wall biogenesis
PX52LOC_RS31945	COG1061	Type III restriction enzyme res subunit
PX52LOC_RS32040	COG0612	Peptidase, M16
PX52LOC_RS32055	COG0243	molybdopterin cofactor binding
PX52LOC_RS32060	COG2815	serine threonine protein kinase
PX52LOC_RS32060	COG0515	serine threonine protein kinase
PX52LOC_RS32065	COG2815	serine threonine protein kinase
PX52LOC_RS32065	COG0515	serine threonine protein kinase
PX52LOC_RS32085	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
PX52LOC_RS32090	COG0154	amidase activity
PX52LOC_RS32095	COG0564	pseudouridine synthase activity
PX52LOC_RS32105	COG4336	lyase activity
PX52LOC_RS32110	COG0673	inositol 2-dehydrogenase activity
PX52LOC_RS32120	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
PX52LOC_RS32135	COG0528	UMP kinase activity
PX52LOC_RS32140	COG0233	cytoplasmic translational termination
PX52LOC_RS32145	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
PX52LOC_RS32175	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PX52LOC_RS32180	COG1187	pseudouridine synthase activity
PX52LOC_RS32190	COG1194	a g-specific adenine glycosylase
PX52LOC_RS32205	COG3119	arylsulfatase activity
PX52LOC_RS32350	COG5002	protein histidine kinase activity
PX52LOC_RS32375	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
PX52LOC_RS32395	COG0671	phosphoesterase, PA-phosphatase related
PX52LOC_RS32410	COG0577	efflux transmembrane transporter activity
PX52LOC_RS32410	COG1136	(ABC) transporter
PX52LOC_RS32450	COG2815	serine threonine protein kinase
PX52LOC_RS32450	COG0515	serine threonine protein kinase
PX52LOC_RS32465	COG2226	methyltransferase
PX52LOC_RS32500	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PX52LOC_RS32555	COG1253	flavin adenine dinucleotide binding
PX52LOC_RS32590	COG4372	Transposase
PX52LOC_RS32610	COG0714	Associated with various cellular activities
PX52LOC_RS32640	COG4999	Histidine kinase
PX52LOC_RS32640	COG2205	protein histidine kinase activity
PX52LOC_RS32640	COG3850	Histidine kinase
PX52LOC_RS32640	COG3437	response regulator, receiver
PX52LOC_RS32675	COG1201	RNA secondary structure unwinding
PX52LOC_RS32680	COG1793	dna ligase
PX52LOC_RS32685	COG1793	dna ligase
PX52LOC_RS32685	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
PX52LOC_RS32705	COG0537	adenosine 5'-monophosphoramidase activity
PX52LOC_RS32710	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
PX52LOC_RS32715	COG1872	DUF167
PX52LOC_RS32720	COG4946	Tricorn protease homolog
PX52LOC_RS32720	COG1506	peptidase
PX52LOC_RS32720	COG0823	Involved in the tonB-independent uptake of proteins
PX52LOC_RS32750	COG0714	Associated with various cellular activities
PX52LOC_RS32810	COG0402	S-adenosylhomocysteine deaminase activity
PX52LOC_RS32830	COG2062	phosphohistidine phosphatase, SixA
PX52LOC_RS32860	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
PX52LOC_RS32870	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
PX52LOC_RS32900	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
PX52LOC_RS32935	COG1410	methionine synthase
PX52LOC_RS32935	COG0646	methionine synthase
PX52LOC_RS32940	COG1131	(ABC) transporter
PX52LOC_RS32955	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
PX52LOC_RS32970	COG0443	Heat shock 70 kDa protein
PX52LOC_RS32975	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
PX52LOC_RS32980	COG0484	heat shock protein binding
PX52LOC_RS32995	COG1108	ABC-type Mn2 Zn2 transport systems permease components
PX52LOC_RS33000	COG1108	ABC-type Mn2 Zn2 transport systems permease components
PX52LOC_RS33005	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
PX52LOC_RS33015	COG4956	integral membrane protein (PIN domain superfamily)
PX52LOC_RS33020	COG0232	Belongs to the dGTPase family. Type 2 subfamily
PX52LOC_RS33030	COG0333	Belongs to the bacterial ribosomal protein bL32 family
PX52LOC_RS33035	COG0416	fatty acid biosynthetic process
PX52LOC_RS33040	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
PX52LOC_RS33045	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
PX52LOC_RS33050	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
PX52LOC_RS33075	COG0501	Belongs to the peptidase M48B family
PX52LOC_RS33100	COG0714	Associated with various cellular activities
PX52LOC_RS33110	COG2304	oxidoreductase activity
PX52LOC_RS33130	COG0456	acetyltransferase
PX52LOC_RS33135	COG2205	protein histidine kinase activity
PX52LOC_RS33135	COG5002	protein histidine kinase activity
PX52LOC_RS33135	COG0784	Response regulator, receiver
PX52LOC_RS33145	COG0133	tryptophan synthase activity
PX52LOC_RS33160	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
PX52LOC_RS33170	COG1940	carbohydrate kinase activity
PX52LOC_RS33220	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
PX52LOC_RS33265	COG1247	-acetyltransferase
PX52LOC_RS33280	COG2165	general secretion pathway protein
PX52LOC_RS33295	COG1609	Transcriptional regulator
PX52LOC_RS33305	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PX52LOC_RS33310	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
PX52LOC_RS33315	COG4977	sequence-specific DNA binding
PX52LOC_RS33315	COG1917	Cupin 2, conserved barrel domain protein
PX52LOC_RS33330	COG1012	belongs to the aldehyde dehydrogenase family
PX52LOC_RS33355	COG2755	lipolytic protein G-D-S-L family
PX52LOC_RS33355	COG0657	acetylesterase activity
PX52LOC_RS33365	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
PX52LOC_RS33375	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PX52LOC_RS33385	COG0322	excinuclease ABC activity
PX52LOC_RS33395	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
PX52LOC_RS33410	COG0515	serine threonine protein kinase
PX52LOC_RS33410	COG2815	serine threonine protein kinase
PX52LOC_RS33415	COG3591	Belongs to the peptidase S1B family
PX52LOC_RS33455	COG1131	(ABC) transporter
PX52LOC_RS33485	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
PX52LOC_RS33565	COG2197	response regulator
PX52LOC_RS33645	COG0758	DNA mediated transformation
PX52LOC_RS33645	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
PX52LOC_RS33780	COG0783	Belongs to the Dps family
PX52LOC_RS33790	COG2202	Pas domain
PX52LOC_RS33790	COG2205	protein histidine kinase activity
PX52LOC_RS33815	COG0577	efflux transmembrane transporter activity
PX52LOC_RS33815	COG1136	(ABC) transporter
PX52LOC_RS33825	COG2217	Heavy metal translocating P-type atpase
PX52LOC_RS33835	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
PX52LOC_RS33840	COG0557	exoribonuclease II activity
PX52LOC_RS33845	COG5609	conserved protein (DUF2294)
PX52LOC_RS33865	COG0745	RESPONSE REGULATOR receiver
PX52LOC_RS33865	COG4566	intracellular signal transduction
PX52LOC_RS33900	COG0443	Heat shock 70 kDa protein
PX52LOC_RS33930	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
PX52LOC_RS34010	COG1061	Type III restriction enzyme res subunit
PX52LOC_RS34075	COG5433	transposase activity
PX52LOC_RS34140	COG1396	sequence-specific DNA binding
PX52LOC_RS34140	COG1917	Cupin 2, conserved barrel domain protein
PX52LOC_RS34150	COG4191	Histidine kinase
PX52LOC_RS34150	COG0784	Response regulator, receiver
PX52LOC_RS34185	COG2801	Transposase and inactivated derivatives
PX52LOC_RS34210	COG0534	Mate efflux family protein
PX52LOC_RS34225	COG3293	Transposase
PX52LOC_RS34285	COG2037	Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT)
PX52LOC_RS34295	COG1029	Formylmethanofuran dehydrogenase, subunit B
PX52LOC_RS34300	COG1229	Formylmethanofuran dehydrogenase subunit A
PX52LOC_RS34305	COG1741	Belongs to the pirin family
PX52LOC_RS34315	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
PX52LOC_RS34315	COG4797	methyltransferase
PX52LOC_RS34320	COG1959	2 iron, 2 sulfur cluster binding
PX52LOC_RS34325	COG1968	undecaprenyl-diphosphatase activity
PX52LOC_RS34335	COG0217	transcriptional regulatory protein
PX52LOC_RS34340	COG0201	protein transport
PX52LOC_RS34345	COG0200	Binds to the 23S rRNA
PX52LOC_RS34350	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
PX52LOC_RS34355	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
PX52LOC_RS34360	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
PX52LOC_RS34365	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
PX52LOC_RS34370	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
PX52LOC_RS34375	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
PX52LOC_RS34380	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
PX52LOC_RS34385	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
PX52LOC_RS34390	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
PX52LOC_RS34395	COG0255	Belongs to the universal ribosomal protein uL29 family
PX52LOC_RS34400	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
PX52LOC_RS34405	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
PX52LOC_RS34410	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
PX52LOC_RS34415	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
PX52LOC_RS34420	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
PX52LOC_RS34425	COG0089	rRNA binding
PX52LOC_RS34430	COG0088	Forms part of the polypeptide exit tunnel
PX52LOC_RS34435	COG0051	transcription antitermination factor activity, RNA binding
PX52LOC_RS34455	COG0505	Belongs to the CarA family
PX52LOC_RS34460	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
PX52LOC_RS34480	COG2204	response regulator
PX52LOC_RS34495	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
PX52LOC_RS34530	COG1108	ABC-type Mn2 Zn2 transport systems permease components
PX52LOC_RS34535	COG0701	Predicted permease
PX52LOC_RS34550	COG0488	(ABC) transporter
PX52LOC_RS34565	COG1166	arginine decarboxylase activity
PX52LOC_RS34580	COG0653	protein targeting
PX52LOC_RS34595	COG0285	dihydrofolate synthase activity
PX52LOC_RS34615	COG0012	GTP binding
PX52LOC_RS34625	COG0515	serine threonine protein kinase
PX52LOC_RS34625	COG2815	serine threonine protein kinase
PX52LOC_RS34630	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
PX52LOC_RS34705	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PX52LOC_RS34710	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PX52LOC_RS34715	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PX52LOC_RS34720	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PX52LOC_RS34740	COG0138	bifunctional purine biosynthesis protein purh
PX52LOC_RS34745	COG1131	(ABC) transporter
PX52LOC_RS34750	COG0657	acetylesterase activity
PX52LOC_RS34750	COG2755	lipolytic protein G-D-S-L family
PX52LOC_RS34755	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PX52LOC_RS34760	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PX52LOC_RS34775	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
PX52LOC_RS34795	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
PX52LOC_RS34810	COG0148	phosphopyruvate hydratase activity
PX52LOC_RS34815	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
PX52LOC_RS34825	COG0723	plastoquinol--plastocyanin reductase activity
PX52LOC_RS34830	COG4251	negative regulation of phosphorylation
PX52LOC_RS34835	COG0784	Response regulator, receiver
PX52LOC_RS34885	COG0778	Nitroreductase
PX52LOC_RS34895	COG0673	inositol 2-dehydrogenase activity
PX52LOC_RS34900	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
PX52LOC_RS34910	COG1295	ribonuclease BN
PX52LOC_RS34940	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
PX52LOC_RS34985	COG0006	proline dipeptidase activity
PX52LOC_RS34990	COG2962	Rard protein
PX52LOC_RS35010	COG4221	oxidoreductase activity
PX52LOC_RS35015	COG0367	asparagine synthase
PX52LOC_RS35040	COG0515	serine threonine protein kinase
PX52LOC_RS35040	COG2815	serine threonine protein kinase
PX52LOC_RS35045	COG0704	Plays a role in the regulation of phosphate uptake
PX52LOC_RS35060	COG1937	Protein conserved in bacteria
PX52LOC_RS35065	COG2217	Heavy metal translocating P-type atpase
PX52LOC_RS35110	COG0515	serine threonine protein kinase
PX52LOC_RS35145	COG0714	Associated with various cellular activities
PX52LOC_RS35150	COG2425	protein containing a von Willebrand factor type A (vWA) domain
PX52LOC_RS35155	COG3552	Protein containing von Willebrand factor type A (VWA) domain
PX52LOC_RS35160	COG0724	RNA recognition motif
PX52LOC_RS35170	COG0828	Belongs to the bacterial ribosomal protein bS21 family
PX52LOC_RS35175	COG0673	inositol 2-dehydrogenase activity
PX52LOC_RS35180	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
PX52LOC_RS35195	COG0346	lactoylglutathione lyase activity
PX52LOC_RS35215	COG1122	ATPase activity
PX52LOC_RS35240	COG1024	Enoyl-CoA hydratase
PX52LOC_RS35285	COG3706	GGDEF domain
PX52LOC_RS35350	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
PX52LOC_RS35355	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
PX52LOC_RS35360	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
PX52LOC_RS35375	COG0463	Glycosyl transferase, family 2
PX52LOC_RS35400	COG0406	alpha-ribazole phosphatase activity
PX52LOC_RS35430	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
PX52LOC_RS35435	COG0436	Aminotransferase
PX52LOC_RS35460	COG0793	Belongs to the peptidase S41A family
PX52LOC_RS35460	COG3409	Peptidoglycan-binding domain 1 protein
PX52LOC_RS35470	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
PX52LOC_RS35480	COG2204	response regulator
PX52LOC_RS35490	COG0793	Belongs to the peptidase S41A family
PX52LOC_RS35490	COG4946	Tricorn protease homolog
PX52LOC_RS35520	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PX52LOC_RS35530	COG1028	Short-chain dehydrogenase reductase Sdr
PX52LOC_RS35565	COG1691	(AIR) carboxylase
PX52LOC_RS35575	COG5002	protein histidine kinase activity
PX52LOC_RS35585	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
PX52LOC_RS35590	COG2198	Histidine kinase
PX52LOC_RS35590	COG0784	Response regulator, receiver
PX52LOC_RS35590	COG2205	protein histidine kinase activity
PX52LOC_RS35595	COG2205	protein histidine kinase activity
PX52LOC_RS35595	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PX52LOC_RS35600	COG1366	Belongs to the anti-sigma-factor antagonist family
PX52LOC_RS35605	COG1366	Belongs to the anti-sigma-factor antagonist family
PX52LOC_RS35610	COG2172	sigma factor antagonist activity
PX52LOC_RS35625	COG2205	protein histidine kinase activity
PX52LOC_RS35625	COG0784	Response regulator, receiver
PX52LOC_RS35630	COG1671	Belongs to the UPF0178 family
PX52LOC_RS35645	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
PX52LOC_RS35650	COG1595	DNA-templated transcription, initiation
PX52LOC_RS35655	COG1028	Short-chain dehydrogenase reductase Sdr
PX52LOC_RS35665	COG1802	Transcriptional regulator
PX52LOC_RS35680	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
PX52LOC_RS35760	COG3485	protocatechuate 3,4-dioxygenase
PX52LOC_RS35765	COG2022	thiamine diphosphate biosynthetic process
PX52LOC_RS35780	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
PX52LOC_RS35795	COG2264	protein methyltransferase activity
PX52LOC_RS35820	COG0753	catalase activity
PX52LOC_RS35865	COG0563	adenylate kinase activity
PX52LOC_RS35895	COG2154	pterin-4-alpha-carbinolamine dehydratase
PX52LOC_RS35900	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
PX52LOC_RS35935	COG3265	gluconokinase activity
PX52LOC_RS35945	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
PX52LOC_RS35955	COG1090	epimerase
PX52LOC_RS35960	COG0114	fumarate hydratase activity
PX52LOC_RS35985	COG1160	GTP binding
PX52LOC_RS36005	COG0134	indole-3-glycerol-phosphate synthase activity
PX52LOC_RS36020	COG0544	peptidyl-prolyl cis-trans isomerase activity
PX52LOC_RS36025	COG0740	serine-type endopeptidase activity
PX52LOC_RS36030	COG0740	serine-type endopeptidase activity
PX52LOC_RS36040	COG0635	Involved in the biosynthesis of porphyrin-containing compound
PX52LOC_RS36060	COG0515	serine threonine protein kinase
PX52LOC_RS36060	COG2815	serine threonine protein kinase
PX52LOC_RS36065	COG2239	Acts as a magnesium transporter
PX52LOC_RS36070	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
PX52LOC_RS36075	COG1127	ABC transporter
PX52LOC_RS36095	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
PX52LOC_RS36100	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
PX52LOC_RS36105	COG0237	dephospho-CoA kinase activity
PX52LOC_RS36115	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
PX52LOC_RS36115	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
PX52LOC_RS36125	COG0736	holo-[acyl-carrier-protein] synthase activity
PX52LOC_RS36135	COG0430	RNA-3'-phosphate cyclase activity
PX52LOC_RS36140	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PX52LOC_RS36150	COG0436	Aminotransferase
PX52LOC_RS36160	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
PX52LOC_RS36180	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
PX52LOC_RS36205	COG0616	signal peptide processing
PX52LOC_RS36220	COG0220	tRNA (guanine-N7-)-methyltransferase activity
PX52LOC_RS36225	COG0438	transferase activity, transferring glycosyl groups
PX52LOC_RS36225	COG1216	Glycosyl transferase, family 2
PX52LOC_RS36240	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PX52LOC_RS36255	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
PX52LOC_RS36260	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
PX52LOC_RS36270	COG0552	protein localization to endoplasmic reticulum
PX52LOC_RS36295	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
PX52LOC_RS36300	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
PX52LOC_RS36305	COG0515	serine threonine protein kinase
PX52LOC_RS36305	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
PX52LOC_RS36325	COG0561	phosphatase activity
PX52LOC_RS36360	COG1858	cytochrome C peroxidase
PX52LOC_RS36375	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
PX52LOC_RS36380	COG0069	glutamate synthase activity
PX52LOC_RS36380	COG0067	glutamate synthase
PX52LOC_RS36380	COG0070	glutamate synthase
PX52LOC_RS36395	COG1331	Highly conserved protein containing a thioredoxin domain
PX52LOC_RS36410	COG1073	alpha beta
PX52LOC_RS36415	COG0523	cobalamin synthesis protein
PX52LOC_RS36430	COG0220	tRNA (guanine-N7-)-methyltransferase activity
PX52LOC_RS36435	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
PX52LOC_RS36460	COG0793	Belongs to the peptidase S41A family
PX52LOC_RS36470	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
PX52LOC_RS36480	COG0746	molybdenum cofactor guanylyltransferase activity
PX52LOC_RS36500	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
PX52LOC_RS36635	COG4968	Prepilin-type N-terminal cleavage methylation domain
PX52LOC_RS36755	COG1695	Transcriptional regulator
PX52LOC_RS36790	COG0745	RESPONSE REGULATOR receiver
PX52LOC_RS36795	COG0515	serine threonine protein kinase
PX52LOC_RS36795	COG2815	serine threonine protein kinase
PX52LOC_RS36945	COG0745	RESPONSE REGULATOR receiver
PX52LOC_RS36950	COG2197	response regulator
PX52LOC_RS36955	COG4585	Histidine kinase
PX52LOC_RS36970	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
PX52LOC_RS36985	COG4566	intracellular signal transduction
PX52LOC_RS36985	COG0745	RESPONSE REGULATOR receiver
PX52LOC_RS37010	COG2197	response regulator
PX52LOC_RS37120	COG2261	transglycosylase associated protein
PX52LOC_RS37235	COG0745	RESPONSE REGULATOR receiver
PX52LOC_RS37265	COG2205	protein histidine kinase activity
PX52LOC_RS37265	COG2198	Histidine kinase
PX52LOC_RS37265	COG0784	Response regulator, receiver
PX52LOC_RS37275	COG2815	serine threonine protein kinase
PX52LOC_RS37275	COG0515	serine threonine protein kinase
PX52LOC_RS37345	COG4584	PFAM Integrase catalytic
PX52LOC_RS37365	COG3852	Histidine kinase
PX52LOC_RS37390	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
PX52LOC_RS37415	COG2198	Histidine kinase
PX52LOC_RS37415	COG0643	Histidine kinase
PX52LOC_RS37420	COG0745	RESPONSE REGULATOR receiver
PX52LOC_RS37430	COG5001	Diguanylate cyclase
PX52LOC_RS37455	COG0643	Histidine kinase
PX52LOC_RS37455	COG2198	Histidine kinase
PX52LOC_RS37475	COG2201	protein-glutamate methylesterase activity
PX52LOC_RS37480	COG2201	protein-glutamate methylesterase activity
PX52LOC_RS37490	COG2205	protein histidine kinase activity
PX52LOC_RS37515	COG2198	Histidine kinase
PX52LOC_RS37515	COG2205	protein histidine kinase activity
PX52LOC_RS37515	COG0784	Response regulator, receiver
PX52LOC_RS37525	COG0724	RNA recognition motif
PX52LOC_RS37560	COG0745	RESPONSE REGULATOR receiver
PX52LOC_RS37560	COG4566	intracellular signal transduction
PX52LOC_RS37710	COG1028	Short-chain dehydrogenase reductase Sdr
PX52LOC_RS37715	COG0753	catalase activity
PX52LOC_RS37730	COG0667	Aldo Keto reductase
PX52LOC_RS37750	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
PX52LOC_RS37750	COG3608	succinylglutamate desuccinylase aspartoacylase
PX52LOC_RS37760	COG2080	2 iron, 2 sulfur cluster binding
PX52LOC_RS37765	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
PX52LOC_RS37770	COG1529	Aldehyde oxidase and xanthine dehydrogenase
PX52LOC_RS37985	COG1404	Belongs to the peptidase S8 family
PX52LOC_RS38090	COG0745	RESPONSE REGULATOR receiver
PX52LOC_RS38095	COG4251	negative regulation of phosphorylation
PX52LOC_RS38190	COG0457	Tetratricopeptide repeat
PX52LOC_RS38190	COG0515	serine threonine protein kinase
PX52LOC_RS38260	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
PX52LOC_RS38400	COG4968	Prepilin-type N-terminal cleavage methylation domain
PX52LOC_RS38405	COG2207	Transcriptional regulator
PX52LOC_RS38405	COG1609	Transcriptional regulator
PX52LOC_RS38410	COG3693	PFAM glycoside hydrolase, family 10
PX52LOC_RS38410	COG2382	esterase
PX52LOC_RS38440	COG0457	Tetratricopeptide repeat
PX52LOC_RS38440	COG0515	serine threonine protein kinase
PX52LOC_RS38445	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
PX52LOC_RS38445	COG0515	serine threonine protein kinase
PX52LOC_RS38470	COG4977	sequence-specific DNA binding
PX52LOC_RS38490	COG3437	response regulator, receiver
PX52LOC_RS38490	COG4999	Histidine kinase
PX52LOC_RS38490	COG3850	Histidine kinase
PX52LOC_RS38490	COG2205	protein histidine kinase activity
PX52LOC_RS38540	COG0300	oxidoreductase activity
PX52LOC_RS38545	COG0156	8-amino-7-oxononanoate synthase activity
PX52LOC_RS38620	COG4260	virion core protein, lumpy skin disease virus
PX52LOC_RS38635	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
PX52LOC_RS38660	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
PX52LOC_RS38660	COG4651	solute:proton antiporter activity
PX52LOC_RS38665	COG1902	pentaerythritol trinitrate reductase activity
PX52LOC_RS38680	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
PX52LOC_RS38710	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
PX52LOC_RS38760	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
PX52LOC_RS38760	COG0515	serine threonine protein kinase
PX52LOC_RS38780	COG4968	Prepilin-type N-terminal cleavage methylation domain
PX52LOC_RS38835	COG2226	methyltransferase
PX52LOC_RS38840	COG2226	methyltransferase
PX52LOC_RS38845	COG0702	epimerase
PX52LOC_RS38875	COG2165	general secretion pathway protein
PX52LOC_RS38925	COG2815	serine threonine protein kinase
PX52LOC_RS38925	COG0515	serine threonine protein kinase
PX52LOC_RS38950	COG0346	lactoylglutathione lyase activity
PX52LOC_RS39085	COG3664	PFAM glycoside hydrolase family 39
PX52LOC_RS39170	COG0515	serine threonine protein kinase
PX52LOC_RS39180	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
PX52LOC_RS39185	COG0544	peptidyl-prolyl cis-trans isomerase activity
PX52LOC_RS39200	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
PX52LOC_RS39230	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
PX52LOC_RS39230	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
PX52LOC_RS39300	COG3541	Predicted nucleotidyltransferase
PX52LOC_RS39315	COG0673	inositol 2-dehydrogenase activity
PX52LOC_RS39320	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
PX52LOC_RS39320	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
PX52LOC_RS39330	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
PX52LOC_RS39330	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
PX52LOC_RS39335	COG0714	Associated with various cellular activities
PX52LOC_RS39365	COG0673	inositol 2-dehydrogenase activity
PX52LOC_RS39380	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
PX52LOC_RS39410	COG0564	pseudouridine synthase activity
PX52LOC_RS39435	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
PX52LOC_RS39440	COG0515	serine threonine protein kinase
PX52LOC_RS39440	COG2815	serine threonine protein kinase
PX52LOC_RS39460	COG0754	glutathionylspermidine amidase activity
PX52LOC_RS39495	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
PX52LOC_RS39500	COG0788	formyltetrahydrofolate deformylase activity
PX52LOC_RS39515	COG0745	RESPONSE REGULATOR receiver
PX52LOC_RS39525	COG0709	Synthesizes selenophosphate from selenide and ATP
PX52LOC_RS39585	COG2815	serine threonine protein kinase
PX52LOC_RS39585	COG0515	serine threonine protein kinase
PX52LOC_RS39590	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
PX52LOC_RS39600	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
PX52LOC_RS39600	COG2755	lipolytic protein G-D-S-L family
PX52LOC_RS39610	COG1215	transferase activity, transferring glycosyl groups
PX52LOC_RS39625	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
PX52LOC_RS39635	COG0436	Aminotransferase
PX52LOC_RS39655	COG1053	succinate dehydrogenase
PX52LOC_RS39670	COG0167	dihydroorotate dehydrogenase activity
PX52LOC_RS39695	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
PX52LOC_RS39705	COG1120	ATPase activity
PX52LOC_RS39715	COG4249	Peptidase C14 caspase catalytic subunit p20
PX52LOC_RS39715	COG2319	Wd-40 repeat
PX52LOC_RS39725	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PX52LOC_RS39735	COG2815	serine threonine protein kinase
PX52LOC_RS39735	COG0515	serine threonine protein kinase
PX52LOC_RS39780	COG0443	Heat shock 70 kDa protein
PX52LOC_RS39800	COG4948	Mandelate Racemase Muconate Lactonizing
PX52LOC_RS39850	COG0166	Belongs to the GPI family
PX52LOC_RS39855	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
PX52LOC_RS39860	COG0515	serine threonine protein kinase
PX52LOC_RS39875	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
PX52LOC_RS39880	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
PX52LOC_RS39885	COG2195	Cleaves the N-terminal amino acid of tripeptides
PX52LOC_RS39915	COG0459	protein refolding
PX52LOC_RS39920	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
PX52LOC_RS39930	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
PX52LOC_RS40090	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
PX52LOC_RS40130	COG0673	inositol 2-dehydrogenase activity
PX52LOC_RS40140	COG0633	Ferredoxin
PX52LOC_RS40155	COG4464	protein tyrosine phosphatase activity
PX52LOC_RS40225	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
PX52LOC_RS40240	COG4372	Transposase
PX52LOC_RS40245	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PX52LOC_RS40290	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
PX52LOC_RS40530	COG0004	ammonium transporteR
PX52LOC_RS40805	COG0640	Transcriptional regulator
PX52LOC_RS40875	COG5002	protein histidine kinase activity
PX52LOC_RS40890	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PX52LOC_RS40890	COG2205	protein histidine kinase activity
PX52LOC_RS40935	COG0411	ABC transporter
PX52LOC_RS40960	COG1040	competence protein
PX52LOC_RS41125	COG0457	Tetratricopeptide repeat
PX52LOC_RS41125	COG0515	serine threonine protein kinase
PX52LOC_RS41365	COG0745	RESPONSE REGULATOR receiver
PX52LOC_RS41455	COG2162	N-hydroxyarylamine O-acetyltransferase activity
PX52LOC_RS41515	COG2382	esterase