locus-tag	class	description
L63ED372_RS00035	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
L63ED372_RS00045	COG2205	protein histidine kinase activity
L63ED372_RS00045	COG0784	Response regulator, receiver
L63ED372_RS00050	COG2197	response regulator
L63ED372_RS00060	COG2211	Major facilitator Superfamily
L63ED372_RS00105	COG0210	DNA helicase
L63ED372_RS00110	COG0679	Auxin Efflux Carrier
L63ED372_RS00115	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
L63ED372_RS00120	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
L63ED372_RS00150	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L63ED372_RS00165	COG0488	(ABC) transporter
L63ED372_RS00250	COG1028	Short-chain dehydrogenase reductase Sdr
L63ED372_RS00260	COG1024	Enoyl-CoA hydratase
L63ED372_RS00265	COG1960	acyl-CoA dehydrogenase activity
L63ED372_RS00305	COG2226	methyltransferase
L63ED372_RS00305	COG1073	alpha beta
L63ED372_RS00320	COG3181	Tripartite tricarboxylate transporter family receptor
L63ED372_RS00325	COG0596	Alpha beta hydrolase
L63ED372_RS00330	COG0653	protein targeting
L63ED372_RS00345	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
L63ED372_RS00350	COG1137	ATPase activity
L63ED372_RS00360	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
L63ED372_RS00370	COG0018	arginyl-trna synthetase
L63ED372_RS00385	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
L63ED372_RS00390	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
L63ED372_RS00410	COG0121	glutamine amidotransferase
L63ED372_RS00415	COG0189	ligase activity
L63ED372_RS00420	COG1597	lipid kinase activity
L63ED372_RS00425	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
L63ED372_RS00430	COG3246	L-lysine catabolic process to acetate
L63ED372_RS00440	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
L63ED372_RS00440	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
L63ED372_RS00440	COG1703	isobutyryl-CoA mutase activity
L63ED372_RS00450	COG0154	amidase activity
L63ED372_RS00455	COG0747	negative chemotaxis
L63ED372_RS00460	COG0601	transmembrane transport
L63ED372_RS00485	COG0739	heme binding
L63ED372_RS00495	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
L63ED372_RS00500	COG1309	transcriptional regulator
L63ED372_RS00515	COG3657	addiction module killer protein
L63ED372_RS00520	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
L63ED372_RS00525	COG1091	dTDP-4-dehydrorhamnose reductase activity
L63ED372_RS00530	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
L63ED372_RS00535	COG1309	transcriptional regulator
L63ED372_RS00600	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
L63ED372_RS00640	COG0438	transferase activity, transferring glycosyl groups
L63ED372_RS00645	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
L63ED372_RS00655	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
L63ED372_RS00695	COG4974	Belongs to the 'phage' integrase family
L63ED372_RS00735	COG1434	Gram-negative-bacterium-type cell wall biogenesis
L63ED372_RS00740	COG0758	DNA mediated transformation
L63ED372_RS00760	COG0242	peptide deformylase activity
L63ED372_RS00765	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
L63ED372_RS00780	COG0126	phosphoglycerate kinase activity
L63ED372_RS00810	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
L63ED372_RS00825	COG3118	belongs to the thioredoxin family
L63ED372_RS00830	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
L63ED372_RS00835	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
L63ED372_RS00840	COG0009	L-threonylcarbamoyladenylate synthase
L63ED372_RS00850	COG4095	Psort location CytoplasmicMembrane, score
L63ED372_RS00855	COG2027	D-alanyl-D-alanine carboxypeptidase
L63ED372_RS00865	COG1214	PFAM Peptidase M22, glycoprotease
L63ED372_RS00870	COG0456	acetyltransferase
L63ED372_RS00875	COG1573	uracil-dna glycosylase
L63ED372_RS00880	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
L63ED372_RS00885	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
L63ED372_RS00895	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
L63ED372_RS00915	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L63ED372_RS00920	COG2175	clavaminate synthase activity
L63ED372_RS00925	COG1012	belongs to the aldehyde dehydrogenase family
L63ED372_RS00925	COG1454	alcohol dehydrogenase
L63ED372_RS00930	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
L63ED372_RS00950	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
L63ED372_RS00955	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
L63ED372_RS00960	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
L63ED372_RS00965	COG0154	amidase activity
L63ED372_RS00970	COG1473	amidohydrolase
L63ED372_RS00975	COG3181	Tripartite tricarboxylate transporter family receptor
L63ED372_RS00980	COG0583	DNA-binding transcription factor activity
L63ED372_RS00985	COG2423	ornithine cyclodeaminase activity
L63ED372_RS00990	COG1522	sequence-specific DNA binding
L63ED372_RS01005	COG0318	PFAM AMP-dependent synthetase and ligase
L63ED372_RS01010	COG0551	DNA topoisomerase type I activity
L63ED372_RS01010	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
L63ED372_RS01020	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
L63ED372_RS01020	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
L63ED372_RS01035	COG0642	Histidine kinase
L63ED372_RS01050	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
L63ED372_RS01055	COG2137	regulation of response to DNA damage stimulus
L63ED372_RS01060	COG4191	Histidine kinase
L63ED372_RS01065	COG0315	cyclic pyranopterin monophosphate synthase activity
L63ED372_RS01070	COG4783	chaperone-mediated protein folding
L63ED372_RS01085	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
L63ED372_RS01090	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
L63ED372_RS01095	COG1862	Preprotein translocase
L63ED372_RS01115	COG5006	permease, DMT superfamily
L63ED372_RS01120	COG0583	DNA-binding transcription factor activity
L63ED372_RS01125	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
L63ED372_RS01170	COG2129	metallophosphoesterase
L63ED372_RS01190	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
L63ED372_RS01190	COG1199	ATP-dependent helicase activity
L63ED372_RS01195	COG1522	sequence-specific DNA binding
L63ED372_RS01205	COG0657	acetylesterase activity
L63ED372_RS01230	COG0697	spore germination
L63ED372_RS01235	COG1136	(ABC) transporter
L63ED372_RS01320	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
L63ED372_RS01330	COG1765	OsmC-like protein
L63ED372_RS01335	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
L63ED372_RS01345	COG3181	Tripartite tricarboxylate transporter family receptor
L63ED372_RS01355	COG0747	negative chemotaxis
L63ED372_RS01365	COG1473	amidohydrolase
L63ED372_RS01370	COG4166	transmembrane transport
L63ED372_RS01375	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L63ED372_RS01380	COG0444	Belongs to the ABC transporter superfamily
L63ED372_RS01385	COG4608	Belongs to the ABC transporter superfamily
L63ED372_RS01445	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
L63ED372_RS01450	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
L63ED372_RS01455	COG0166	Belongs to the GPI family
L63ED372_RS01460	COG0484	heat shock protein binding
L63ED372_RS01490	COG0459	protein refolding
L63ED372_RS01495	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
L63ED372_RS01505	COG2890	protein-(glutamine-N5) methyltransferase activity
L63ED372_RS01510	COG1560	Kdo2-lipid A biosynthetic process
L63ED372_RS01515	COG2267	carboxylic ester hydrolase activity
L63ED372_RS01520	COG0218	Necessary for normal cell division and for the maintenance of normal septation
L63ED372_RS01530	COG1333	cytochrome c biogenesis protein
L63ED372_RS01535	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
L63ED372_RS01545	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
L63ED372_RS01550	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
L63ED372_RS01560	COG1965	Belongs to the frataxin family
L63ED372_RS01590	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
L63ED372_RS01600	COG1960	acyl-CoA dehydrogenase activity
L63ED372_RS01610	COG1024	Enoyl-CoA hydratase
L63ED372_RS01615	COG2050	protein possibly involved in aromatic compounds catabolism
L63ED372_RS01625	COG5265	(ABC) transporter
L63ED372_RS01630	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L63ED372_RS01635	COG2151	metal-sulfur cluster biosynthetic enzyme
L63ED372_RS01640	COG3396	Phenylacetate-CoA oxygenase
L63ED372_RS01645	COG3460	Phenylacetate-CoA oxygenase
L63ED372_RS01650	COG3396	Phenylacetate-CoA oxygenase
L63ED372_RS01655	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
L63ED372_RS01660	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
L63ED372_RS01665	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
L63ED372_RS01670	COG0316	Belongs to the HesB IscA family
L63ED372_RS01675	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
L63ED372_RS01680	COG0739	heme binding
L63ED372_RS01685	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
L63ED372_RS01690	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
L63ED372_RS01695	COG1490	D-aminoacyl-tRNA deacylase activity
L63ED372_RS01700	COG0513	Belongs to the DEAD box helicase family
L63ED372_RS01705	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
L63ED372_RS01710	COG1702	phosphate starvation-inducible protein PhoH
L63ED372_RS01715	COG0632	four-way junction helicase activity
L63ED372_RS01720	COG2255	four-way junction helicase activity
L63ED372_RS01730	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L63ED372_RS01735	COG4597	amino acid ABC transporter
L63ED372_RS01740	COG0765	amino acid transport
L63ED372_RS01745	COG1126	abc transporter atp-binding protein
L63ED372_RS01750	COG0418	dihydroorotase activity
L63ED372_RS01760	COG0501	Belongs to the peptidase M48B family
L63ED372_RS01775	COG0037	tRNA processing
L63ED372_RS01840	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
L63ED372_RS01850	COG0617	tRNA 3'-terminal CCA addition
L63ED372_RS01870	COG1473	amidohydrolase
L63ED372_RS01875	COG0243	molybdopterin cofactor binding
L63ED372_RS01885	COG1196	nuclear chromosome segregation
L63ED372_RS01885	COG0741	lytic transglycosylase activity
L63ED372_RS01885	COG0739	heme binding
L63ED372_RS01890	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
L63ED372_RS01900	COG1660	Displays ATPase and GTPase activities
L63ED372_RS01905	COG0497	DNA recombination
L63ED372_RS01910	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
L63ED372_RS01915	COG1420	regulation of RNA biosynthetic process
L63ED372_RS01955	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
L63ED372_RS01985	COG3191	aminopeptidase activity
L63ED372_RS01995	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L63ED372_RS02005	COG4608	Belongs to the ABC transporter superfamily
L63ED372_RS02010	COG0747	negative chemotaxis
L63ED372_RS02025	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
L63ED372_RS02030	COG1758	RNA polymerase activity
L63ED372_RS02035	COG0194	GDP metabolic process
L63ED372_RS02040	COG1561	YicC-like family, N-terminal region
L63ED372_RS02045	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
L63ED372_RS02050	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
L63ED372_RS02055	COG0635	Involved in the biosynthesis of porphyrin-containing compound
L63ED372_RS02090	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
L63ED372_RS02095	COG0830	nickel cation binding
L63ED372_RS02100	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
L63ED372_RS02105	COG0804	urea catabolic process
L63ED372_RS02110	COG0832	Belongs to the urease beta subunit family
L63ED372_RS02120	COG0831	urea catabolic process
L63ED372_RS02160	COG0300	oxidoreductase activity
L63ED372_RS02175	COG0829	nickel cation binding
L63ED372_RS02180	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L63ED372_RS02185	COG1116	anion transmembrane transporter activity
L63ED372_RS02190	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L63ED372_RS02195	COG2233	PERMEase
L63ED372_RS02210	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
L63ED372_RS02225	COG2186	Transcriptional regulator
L63ED372_RS02240	COG1529	Aldehyde oxidase and xanthine dehydrogenase
L63ED372_RS02255	COG0318	PFAM AMP-dependent synthetase and ligase
L63ED372_RS02260	COG0385	Bile acid
L63ED372_RS02295	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
L63ED372_RS02310	COG1473	amidohydrolase
L63ED372_RS02315	COG0583	DNA-binding transcription factor activity
L63ED372_RS02360	COG3118	belongs to the thioredoxin family
L63ED372_RS02370	COG0402	S-adenosylhomocysteine deaminase activity
L63ED372_RS02375	COG1529	Aldehyde oxidase and xanthine dehydrogenase
L63ED372_RS02390	COG3845	ABC transporter
L63ED372_RS02395	COG4603	Belongs to the binding-protein-dependent transport system permease family
L63ED372_RS02425	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
L63ED372_RS02435	COG2079	MmgE PrpD family protein
L63ED372_RS02455	COG0717	Belongs to the dCTP deaminase family
L63ED372_RS02475	COG0446	pyridine nucleotide-disulphide oxidoreductase
L63ED372_RS02485	COG2391	methyltransferase activity
L63ED372_RS02490	COG2391	methyltransferase activity
L63ED372_RS02500	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
L63ED372_RS02515	COG0446	pyridine nucleotide-disulphide oxidoreductase
L63ED372_RS02525	COG0583	DNA-binding transcription factor activity
L63ED372_RS02540	COG4451	ribulose bisphosphate carboxylase, small
L63ED372_RS02570	COG0450	alkyl hydroperoxide reductase
L63ED372_RS02585	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
L63ED372_RS02590	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
L63ED372_RS02595	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
L63ED372_RS02600	COG3954	Phosphoribulokinase
L63ED372_RS02605	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
L63ED372_RS02610	COG0546	phosphoglycolate phosphatase activity
L63ED372_RS02615	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
L63ED372_RS02620	COG0126	phosphoglycerate kinase activity
L63ED372_RS02625	COG0191	fructose-bisphosphate aldolase activity
L63ED372_RS02665	COG1937	Protein conserved in bacteria
L63ED372_RS02670	COG0640	Transcriptional regulator
L63ED372_RS02710	COG3439	Domain of unknown function DUF302
L63ED372_RS02725	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
L63ED372_RS02730	COG4654	Cytochrome c, class I
L63ED372_RS02840	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
L63ED372_RS02845	COG1061	Type III restriction enzyme res subunit
L63ED372_RS02850	COG1002	Type II restriction enzyme, methylase subunits
L63ED372_RS02860	COG1002	Type II restriction enzyme, methylase subunits
L63ED372_RS02920	COG0183	Belongs to the thiolase family
L63ED372_RS02935	COG0559	Belongs to the binding-protein-dependent transport system permease family
L63ED372_RS02940	COG1172	Belongs to the binding-protein-dependent transport system permease family
L63ED372_RS02955	COG1022	Amp-dependent synthetase and ligase
L63ED372_RS02965	COG0861	Integral membrane protein TerC family
L63ED372_RS02970	COG0583	DNA-binding transcription factor activity
L63ED372_RS02980	COG1960	acyl-CoA dehydrogenase activity
L63ED372_RS02990	COG1024	Enoyl-CoA hydratase
L63ED372_RS02995	COG1960	acyl-CoA dehydrogenase activity
L63ED372_RS03000	COG4335	DNA alkylation repair
L63ED372_RS03005	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
L63ED372_RS03015	COG1309	transcriptional regulator
L63ED372_RS03025	COG0183	Belongs to the thiolase family
L63ED372_RS03065	COG1944	ATP diphosphatase activity
L63ED372_RS03070	COG0697	spore germination
L63ED372_RS03080	COG0415	Belongs to the DNA photolyase family
L63ED372_RS03085	COG0415	Belongs to the DNA photolyase family
L63ED372_RS03095	COG1959	2 iron, 2 sulfur cluster binding
L63ED372_RS03110	COG0604	alcohol dehydrogenase
L63ED372_RS03115	COG1132	(ABC) transporter
L63ED372_RS03125	COG0142	geranyltranstransferase activity
L63ED372_RS03130	COG0500	methyltransferase
L63ED372_RS03135	COG1063	alcohol dehydrogenase
L63ED372_RS03140	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
L63ED372_RS03145	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
L63ED372_RS03150	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
L63ED372_RS03205	COG2814	Major facilitator Superfamily
L63ED372_RS03210	COG0724	RNA recognition motif
L63ED372_RS03225	COG1562	ergosterol biosynthetic process
L63ED372_RS03230	COG1233	COG1233 Phytoene dehydrogenase and related
L63ED372_RS03240	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
L63ED372_RS03270	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
L63ED372_RS03275	COG1429	ligase activity, forming nitrogen-metal bonds
L63ED372_RS03280	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
L63ED372_RS03305	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
L63ED372_RS03310	COG2211	Major facilitator Superfamily
L63ED372_RS03315	COG0644	oxidoreductase
L63ED372_RS03330	COG0596	Alpha beta hydrolase
L63ED372_RS03335	COG2267	carboxylic ester hydrolase activity
L63ED372_RS03340	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
L63ED372_RS03350	COG1035	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus
L63ED372_RS03365	COG4133	protoheme IX ABC transporter activity
L63ED372_RS03385	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
L63ED372_RS03400	COG3088	subunit of a heme lyase
L63ED372_RS03410	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
L63ED372_RS03435	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
L63ED372_RS03440	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
L63ED372_RS03450	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
L63ED372_RS03455	COG2003	Belongs to the UPF0758 family
L63ED372_RS03460	COG1047	Peptidyl-prolyl cis-trans
L63ED372_RS03465	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
L63ED372_RS03470	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
L63ED372_RS03485	COG2197	response regulator
L63ED372_RS03490	COG0180	Tryptophanyl-tRNA synthetase
L63ED372_RS03495	COG1994	Peptidase M50
L63ED372_RS03500	COG1473	amidohydrolase
L63ED372_RS03520	COG0516	GMP reductase activity
L63ED372_RS03530	COG0210	DNA helicase
L63ED372_RS03545	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
L63ED372_RS03560	COG0625	glutathione transferase activity
L63ED372_RS03565	COG0412	Dienelactone hydrolase
L63ED372_RS03580	COG0697	spore germination
L63ED372_RS03590	COG1722	exodeoxyribonuclease VII activity
L63ED372_RS03595	COG0142	geranyltranstransferase activity
L63ED372_RS03600	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
L63ED372_RS03605	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
L63ED372_RS03615	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
L63ED372_RS03620	COG1910	domain protein
L63ED372_RS03645	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
L63ED372_RS03650	COG2414	aldehyde ferredoxin oxidoreductase
L63ED372_RS03675	COG3158	transport of potassium into the cell
L63ED372_RS03680	COG0745	RESPONSE REGULATOR receiver
L63ED372_RS03685	COG2205	protein histidine kinase activity
L63ED372_RS03690	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
L63ED372_RS03695	COG2974	May be involved in recombination
L63ED372_RS03710	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
L63ED372_RS03735	COG0318	PFAM AMP-dependent synthetase and ligase
L63ED372_RS03740	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L63ED372_RS03755	COG1666	GTP binding
L63ED372_RS03760	COG0812	UDP-N-acetylmuramate dehydrogenase activity
L63ED372_RS03770	COG0137	argininosuccinate synthase activity
L63ED372_RS03775	COG3123	guanosine phosphorylase activity
L63ED372_RS03785	COG1393	Belongs to the ArsC family
L63ED372_RS03790	COG0285	dihydrofolate synthase activity
L63ED372_RS03815	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
L63ED372_RS03865	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
L63ED372_RS03875	COG2175	clavaminate synthase activity
L63ED372_RS03925	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
L63ED372_RS03925	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
L63ED372_RS03930	COG1643	Atp-dependent helicase
L63ED372_RS03950	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
L63ED372_RS03970	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
L63ED372_RS03975	COG0181	hydroxymethylbilane synthase activity
L63ED372_RS03995	COG1530	ribonuclease E activity
L63ED372_RS04005	COG0564	pseudouridine synthase activity
L63ED372_RS04020	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
L63ED372_RS04020	COG0616	signal peptide processing
L63ED372_RS04025	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
L63ED372_RS04030	COG0424	maF-like protein
L63ED372_RS04035	COG1399	metal-binding, possibly nucleic acid-binding protein
L63ED372_RS04040	COG0333	Belongs to the bacterial ribosomal protein bL32 family
L63ED372_RS04045	COG0416	fatty acid biosynthetic process
L63ED372_RS04050	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
L63ED372_RS04055	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
L63ED372_RS04060	COG1028	Short-chain dehydrogenase reductase Sdr
L63ED372_RS04070	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
L63ED372_RS04080	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L63ED372_RS04085	COG0481	GTPase activity
L63ED372_RS04090	COG0681	Belongs to the peptidase S26 family
L63ED372_RS04095	COG0571	ribonuclease III activity
L63ED372_RS04100	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
L63ED372_RS04105	COG1381	Involved in DNA repair and RecF pathway recombination
L63ED372_RS04110	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
L63ED372_RS04115	COG0736	holo-[acyl-carrier-protein] synthase activity
L63ED372_RS04120	COG1472	Belongs to the glycosyl hydrolase 3 family
L63ED372_RS04130	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
L63ED372_RS04140	COG0762	integral membrane protein
L63ED372_RS04145	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
L63ED372_RS04150	COG0159	tryptophan synthase activity
L63ED372_RS04155	COG0133	tryptophan synthase activity
L63ED372_RS04160	COG0135	phosphoribosylanthranilate isomerase activity
L63ED372_RS04165	COG0101	tRNA pseudouridine synthase activity
L63ED372_RS04175	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
L63ED372_RS04180	COG0385	Bile acid
L63ED372_RS04190	COG0473	3-isopropylmalate dehydrogenase activity
L63ED372_RS04195	COG0066	3-isopropylmalate dehydratase activity
L63ED372_RS04200	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
L63ED372_RS04205	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
L63ED372_RS04215	COG0776	regulation of translation
L63ED372_RS04225	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
L63ED372_RS04230	COG0287	Prephenate dehydrogenase
L63ED372_RS04240	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
L63ED372_RS04260	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
L63ED372_RS04265	COG0546	phosphoglycolate phosphatase activity
L63ED372_RS04280	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
L63ED372_RS04290	COG0820	rRNA (adenine-C2-)-methyltransferase activity
L63ED372_RS04345	COG1538	Outer membrane efflux protein
L63ED372_RS04355	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
L63ED372_RS04370	COG1309	transcriptional regulator
L63ED372_RS04410	COG1960	acyl-CoA dehydrogenase activity
L63ED372_RS04415	COG0583	DNA-binding transcription factor activity
L63ED372_RS04420	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
L63ED372_RS04435	COG4206	TonB-dependent receptor
L63ED372_RS04445	COG0483	inositol monophosphate 1-phosphatase activity
L63ED372_RS04450	COG2188	Transcriptional regulator
L63ED372_RS04455	COG2855	membrane
L63ED372_RS04460	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
L63ED372_RS04470	COG2721	sulfolactate sulfo-lyase activity
L63ED372_RS04485	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
L63ED372_RS04490	COG1028	Short-chain dehydrogenase reductase Sdr
L63ED372_RS04495	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
L63ED372_RS04510	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L63ED372_RS04515	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L63ED372_RS04520	COG1609	Transcriptional regulator
L63ED372_RS04525	COG0259	pyridoxamine-phosphate oxidase activity
L63ED372_RS04545	COG0800	Aldolase
L63ED372_RS04555	COG0346	lactoylglutathione lyase activity
L63ED372_RS04565	COG1028	Short-chain dehydrogenase reductase Sdr
L63ED372_RS04580	COG3148	PFAM DTW domain containing protein
L63ED372_RS04595	COG0800	Aldolase
L63ED372_RS04615	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
L63ED372_RS04620	COG0129	dihydroxy-acid dehydratase activity
L63ED372_RS04625	COG2186	Transcriptional regulator
L63ED372_RS04630	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
L63ED372_RS04635	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
L63ED372_RS04640	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
L63ED372_RS04645	COG4948	Mandelate Racemase Muconate Lactonizing
L63ED372_RS04650	COG1028	Short-chain dehydrogenase reductase Sdr
L63ED372_RS04655	COG1063	alcohol dehydrogenase
L63ED372_RS04660	COG1028	Short-chain dehydrogenase reductase Sdr
L63ED372_RS04665	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
L63ED372_RS04670	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
L63ED372_RS04675	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
L63ED372_RS04685	COG3265	gluconokinase activity
L63ED372_RS04690	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
L63ED372_RS04695	COG1609	Transcriptional regulator
L63ED372_RS04700	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
L63ED372_RS04710	COG0513	Belongs to the DEAD box helicase family
L63ED372_RS04715	COG3181	Tripartite tricarboxylate transporter family receptor
L63ED372_RS04720	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
L63ED372_RS04725	COG0488	(ABC) transporter
L63ED372_RS04740	COG1028	Short-chain dehydrogenase reductase Sdr
L63ED372_RS04745	COG0840	transmembrane signaling receptor activity
L63ED372_RS04765	COG2951	lytic endotransglycosylase activity
L63ED372_RS04770	COG0123	including yeast histone deacetylase and acetoin utilization protein
L63ED372_RS04780	COG1196	nuclear chromosome segregation
L63ED372_RS04780	COG3264	Mechanosensitive ion channel
L63ED372_RS04810	COG1960	acyl-CoA dehydrogenase activity
L63ED372_RS04825	COG0189	ligase activity
L63ED372_RS04825	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
L63ED372_RS04830	COG1181	Belongs to the D-alanine--D-alanine ligase family
L63ED372_RS04830	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
L63ED372_RS04835	COG1132	(ABC) transporter
L63ED372_RS04845	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
L63ED372_RS04850	COG0484	heat shock protein binding
L63ED372_RS04855	COG0443	Heat shock 70 kDa protein
L63ED372_RS04860	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
L63ED372_RS04875	COG2885	chlorophyll binding
L63ED372_RS04885	COG1960	acyl-CoA dehydrogenase activity
L63ED372_RS04900	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L63ED372_RS04915	COG0183	Belongs to the thiolase family
L63ED372_RS04925	COG1024	Enoyl-CoA hydratase
L63ED372_RS04930	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
L63ED372_RS05005	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
L63ED372_RS05010	COG1684	flagellar biosynthetic protein fliR
L63ED372_RS05025	COG3190	flagellar
L63ED372_RS05025	COG1338	Plays a role in the flagellum-specific transport system
L63ED372_RS05050	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
L63ED372_RS05095	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
L63ED372_RS05105	COG0625	glutathione transferase activity
L63ED372_RS05110	COG1562	ergosterol biosynthetic process
L63ED372_RS05125	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
L63ED372_RS05135	COG0544	peptidyl-prolyl cis-trans isomerase activity
L63ED372_RS05140	COG0740	serine-type endopeptidase activity
L63ED372_RS05145	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
L63ED372_RS05150	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
L63ED372_RS05175	COG0436	Aminotransferase
L63ED372_RS05180	COG0545	Peptidyl-prolyl cis-trans isomerase
L63ED372_RS05190	COG0625	glutathione transferase activity
L63ED372_RS05215	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
L63ED372_RS05230	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L63ED372_RS05245	COG1752	Esterase of the alpha-beta hydrolase superfamily
L63ED372_RS05265	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
L63ED372_RS05315	COG3128	pkhd-type hydroxylase
L63ED372_RS05325	COG1840	ABC-type Fe3 transport system, periplasmic component
L63ED372_RS05330	COG1752	Esterase of the alpha-beta hydrolase superfamily
L63ED372_RS05340	COG0123	including yeast histone deacetylase and acetoin utilization protein
L63ED372_RS05345	COG0824	Thioesterase
L63ED372_RS05355	COG0559	Belongs to the binding-protein-dependent transport system permease family
L63ED372_RS05360	COG1137	ATPase activity
L63ED372_RS05370	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
L63ED372_RS05395	COG1611	Belongs to the LOG family
L63ED372_RS05400	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
L63ED372_RS05435	COG0322	excinuclease ABC activity
L63ED372_RS05440	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
L63ED372_RS05450	COG0473	3-isopropylmalate dehydrogenase activity
L63ED372_RS05465	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
L63ED372_RS05475	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
L63ED372_RS05480	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
L63ED372_RS05480	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
L63ED372_RS05485	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
L63ED372_RS05485	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
L63ED372_RS05490	COG0521	Mo-molybdopterin cofactor biosynthetic process
L63ED372_RS05500	COG0312	modulator of DNA gyrase
L63ED372_RS05515	COG0828	Belongs to the bacterial ribosomal protein bS21 family
L63ED372_RS05525	COG2081	HI0933 family
L63ED372_RS05540	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
L63ED372_RS05545	COG0683	leucine binding
L63ED372_RS05555	COG3181	Tripartite tricarboxylate transporter family receptor
L63ED372_RS05570	COG2271	Major facilitator Superfamily
L63ED372_RS05610	COG0322	excinuclease ABC activity
L63ED372_RS05635	COG1403	HNH endonuclease
L63ED372_RS05680	COG2159	amidohydrolase
L63ED372_RS05715	COG0477	Major facilitator Superfamily
L63ED372_RS05725	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
L63ED372_RS05730	COG2084	Dehydrogenase
L63ED372_RS05735	COG1309	transcriptional regulator
L63ED372_RS05740	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
L63ED372_RS05745	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
L63ED372_RS05750	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
L63ED372_RS05755	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
L63ED372_RS05780	COG0642	Histidine kinase
L63ED372_RS05790	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
L63ED372_RS05810	COG3119	arylsulfatase activity
L63ED372_RS05815	COG3181	Tripartite tricarboxylate transporter family receptor
L63ED372_RS05825	COG0667	Aldo Keto reductase
L63ED372_RS05835	COG2188	Transcriptional regulator
L63ED372_RS05860	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L63ED372_RS05865	COG1012	belongs to the aldehyde dehydrogenase family
L63ED372_RS05865	COG2030	dehydratase
L63ED372_RS05905	COG1028	Short-chain dehydrogenase reductase Sdr
L63ED372_RS05915	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
L63ED372_RS05935	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
L63ED372_RS05940	COG4566	intracellular signal transduction
L63ED372_RS05950	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
L63ED372_RS05955	COG0508	dehydrogenase complex catalyzes the overall conversion of
L63ED372_RS05960	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L63ED372_RS05995	COG3932	Exopolysaccharide synthesis, ExoD
L63ED372_RS06010	COG2205	protein histidine kinase activity
L63ED372_RS06020	COG4143	(ABC) transporter
L63ED372_RS06030	COG3842	ATPase activity
L63ED372_RS06040	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L63ED372_RS06045	COG3485	protocatechuate 3,4-dioxygenase
L63ED372_RS06050	COG0179	Fumarylacetoacetate (FAA) hydrolase
L63ED372_RS06055	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
L63ED372_RS06060	COG1487	ribonuclease activity
L63ED372_RS06065	COG2272	Belongs to the type-B carboxylesterase lipase family
L63ED372_RS06070	COG3181	Tripartite tricarboxylate transporter family receptor
L63ED372_RS06080	COG0514	ATP-dependent DNA helicase (RecQ)
L63ED372_RS06095	COG1473	amidohydrolase
L63ED372_RS06110	COG0601	transmembrane transport
L63ED372_RS06115	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L63ED372_RS06120	COG0444	Belongs to the ABC transporter superfamily
L63ED372_RS06125	COG4608	Belongs to the ABC transporter superfamily
L63ED372_RS06130	COG1446	asparaginase
L63ED372_RS06135	COG1804	L-carnitine dehydratase bile acid-inducible protein F
L63ED372_RS06145	COG3181	Tripartite tricarboxylate transporter family receptor
L63ED372_RS06160	COG0791	NLP P60 protein
L63ED372_RS06175	COG0567	Dehydrogenase, E1 component
L63ED372_RS06180	COG0508	dehydrogenase complex catalyzes the overall conversion of
L63ED372_RS06185	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L63ED372_RS06190	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
L63ED372_RS06205	COG1199	ATP-dependent helicase activity
L63ED372_RS06215	COG0564	pseudouridine synthase activity
L63ED372_RS06220	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
L63ED372_RS06225	COG1187	pseudouridine synthase activity
L63ED372_RS06230	COG0105	UTP biosynthetic process
L63ED372_RS06235	COG0820	rRNA (adenine-C2-)-methyltransferase activity
L63ED372_RS06245	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
L63ED372_RS06250	COG0124	histidyl-tRNA synthetase
L63ED372_RS06265	COG1160	GTP binding
L63ED372_RS06270	COG1923	regulation of RNA biosynthetic process
L63ED372_RS06275	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
L63ED372_RS06280	COG0330	HflC and HflK could
L63ED372_RS06285	COG0330	HflC and HflK could
L63ED372_RS06290	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
L63ED372_RS06295	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
L63ED372_RS06320	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
L63ED372_RS06330	COG4181	ATPase activity
L63ED372_RS06335	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
L63ED372_RS06345	COG2059	Chromate
L63ED372_RS06355	COG1739	Uncharacterized protein family UPF0029
L63ED372_RS06385	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
L63ED372_RS06390	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
L63ED372_RS06410	COG1262	PFAM Formylglycine-generating sulfatase enzyme
L63ED372_RS06425	COG0784	Response regulator, receiver
L63ED372_RS06425	COG2205	protein histidine kinase activity
L63ED372_RS06430	COG1280	lysine exporter protein (LysE YggA)
L63ED372_RS06455	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
L63ED372_RS06455	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
L63ED372_RS06460	COG0509	glycine decarboxylation via glycine cleavage system
L63ED372_RS06465	COG0404	The glycine cleavage system catalyzes the degradation of glycine
L63ED372_RS06470	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
L63ED372_RS06470	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
L63ED372_RS06480	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
L63ED372_RS06490	COG1028	Short-chain dehydrogenase reductase Sdr
L63ED372_RS06515	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
L63ED372_RS06520	COG1960	acyl-CoA dehydrogenase activity
L63ED372_RS06535	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
L63ED372_RS06555	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
L63ED372_RS06565	COG1802	Transcriptional regulator
L63ED372_RS06570	COG0247	lactate metabolic process
L63ED372_RS06580	COG0220	tRNA (guanine-N7-)-methyltransferase activity
L63ED372_RS06585	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
L63ED372_RS06590	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L63ED372_RS06605	COG0242	peptide deformylase activity
L63ED372_RS06615	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L63ED372_RS06625	COG0436	Aminotransferase
L63ED372_RS06630	COG0583	DNA-binding transcription factor activity
L63ED372_RS06640	COG0795	lipopolysaccharide-transporting ATPase activity
L63ED372_RS06650	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
L63ED372_RS06685	COG4166	transmembrane transport
L63ED372_RS06690	COG4174	ABC transporter (Permease)
L63ED372_RS06695	COG4239	(ABC) transporter, permease
L63ED372_RS06700	COG4172	Belongs to the ABC transporter superfamily
L63ED372_RS06705	COG0779	Required for maturation of 30S ribosomal subunits
L63ED372_RS06710	COG0195	Participates in both transcription termination and antitermination
L63ED372_RS06710	COG2251	uridine kinase activity
L63ED372_RS06715	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
L63ED372_RS06720	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
L63ED372_RS06725	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
L63ED372_RS06730	COG1217	gtp-binding protein TYPA
L63ED372_RS06740	COG1024	Enoyl-CoA hydratase
L63ED372_RS06745	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
L63ED372_RS06750	COG2867	negative regulation of translational initiation
L63ED372_RS06755	COG2914	Belongs to the UPF0125 (RnfH) family
L63ED372_RS06760	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
L63ED372_RS06770	COG0518	GMP synthase (glutamine-hydrolyzing) activity
L63ED372_RS06770	COG0519	Catalyzes the synthesis of GMP from XMP
L63ED372_RS06785	COG1619	proteins homologs of microcin C7 resistance protein MccF
L63ED372_RS06800	COG0084	hydrolase, TatD family'
L63ED372_RS06805	COG0470	DNA polymerase III
L63ED372_RS06810	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
L63ED372_RS06815	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
L63ED372_RS06820	COG0354	folic acid binding
L63ED372_RS06830	COG0657	acetylesterase activity
L63ED372_RS06845	COG1054	Belongs to the UPF0176 family
L63ED372_RS06860	COG2183	response to ionizing radiation
L63ED372_RS06885	COG2130	NADP-dependent
L63ED372_RS06895	COG1028	Short-chain dehydrogenase reductase Sdr
L63ED372_RS06905	COG1960	acyl-CoA dehydrogenase activity
L63ED372_RS06910	COG0183	Belongs to the thiolase family
L63ED372_RS06915	COG1250	3-hydroxyacyl-CoA dehydrogenase
L63ED372_RS06915	COG1024	Enoyl-CoA hydratase
L63ED372_RS06925	COG0411	ABC transporter
L63ED372_RS06945	COG0318	PFAM AMP-dependent synthetase and ligase
L63ED372_RS06950	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
L63ED372_RS06955	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
L63ED372_RS06960	COG2917	probably involved in intracellular septation
L63ED372_RS06965	COG0271	Belongs to the BolA IbaG family
L63ED372_RS06970	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
L63ED372_RS06975	COG0826	peptidase U32
L63ED372_RS06985	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
L63ED372_RS06990	COG0047	phosphoribosylformylglycinamidine synthase activity
L63ED372_RS06990	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
L63ED372_RS06995	COG0460	homoserine dehydrogenase
L63ED372_RS07000	COG5285	phytanoyl-CoA dioxygenase
L63ED372_RS07010	COG0024	Methionine aminopeptidase
L63ED372_RS07015	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
L63ED372_RS07025	COG2814	Major facilitator Superfamily
L63ED372_RS07030	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
L63ED372_RS07035	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L63ED372_RS07050	COG2239	Acts as a magnesium transporter
L63ED372_RS07065	COG2267	carboxylic ester hydrolase activity
L63ED372_RS07070	COG2124	cytochrome p450
L63ED372_RS07080	COG1295	ribonuclease BN
L63ED372_RS07090	COG0277	FAD linked oxidase domain protein
L63ED372_RS07095	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
L63ED372_RS07105	COG0708	Exodeoxyribonuclease III
L63ED372_RS07115	COG2308	Evidence 4 Homologs of previously reported genes of
L63ED372_RS07175	COG0275	rRNA processing
L63ED372_RS07180	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L63ED372_RS07185	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
L63ED372_RS07190	COG2850	peptidyl-arginine hydroxylation
L63ED372_RS07195	COG1047	Peptidyl-prolyl cis-trans
L63ED372_RS07200	COG0756	dUTP diphosphatase activity
L63ED372_RS07205	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
L63ED372_RS07210	COG0504	CTP synthase activity
L63ED372_RS07215	COG2877	3-deoxy-8-phosphooctulonate synthase activity
L63ED372_RS07225	COG0148	phosphopyruvate hydratase activity
L63ED372_RS07230	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
L63ED372_RS07255	COG3842	ATPase activity
L63ED372_RS07265	COG1840	ABC-type Fe3 transport system, periplasmic component
L63ED372_RS07300	COG2204	response regulator
L63ED372_RS07310	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L63ED372_RS07330	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
L63ED372_RS07330	COG2885	chlorophyll binding
L63ED372_RS07335	COG0560	Phosphoserine phosphatase
L63ED372_RS07340	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
L63ED372_RS07350	COG1196	nuclear chromosome segregation
L63ED372_RS07355	COG0436	Aminotransferase
L63ED372_RS07360	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
L63ED372_RS07365	COG2890	protein-(glutamine-N5) methyltransferase activity
L63ED372_RS07370	COG0488	(ABC) transporter
L63ED372_RS07380	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
L63ED372_RS07385	COG2391	methyltransferase activity
L63ED372_RS07400	COG0823	Involved in the tonB-independent uptake of proteins
L63ED372_RS07405	COG1132	(ABC) transporter
L63ED372_RS07415	COG0424	maF-like protein
L63ED372_RS07420	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
L63ED372_RS07425	COG0799	negative regulation of ribosome biogenesis
L63ED372_RS07430	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
L63ED372_RS07435	COG0408	coproporphyrinogen oxidase activity
L63ED372_RS07445	COG0151	Belongs to the GarS family
L63ED372_RS07450	COG0217	transcriptional regulatory protein
L63ED372_RS07455	COG0433	COG0433 Predicted ATPase
L63ED372_RS07460	COG0542	response to heat
L63ED372_RS07465	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
L63ED372_RS07470	COG1278	Cold shock
L63ED372_RS07485	COG0776	regulation of translation
L63ED372_RS07490	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L63ED372_RS07490	COG0072	phenylalanine-tRNA ligase activity
L63ED372_RS07495	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
L63ED372_RS07500	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
L63ED372_RS07505	COG0291	Belongs to the bacterial ribosomal protein bL35 family
L63ED372_RS07510	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
L63ED372_RS07515	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
L63ED372_RS07535	COG0028	Belongs to the TPP enzyme family
L63ED372_RS07540	COG0542	response to heat
L63ED372_RS07550	COG0314	molybdopterin synthase activity
L63ED372_RS07555	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
L63ED372_RS07560	COG0303	'Molybdopterin
L63ED372_RS07575	COG0436	Aminotransferase
L63ED372_RS07585	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
L63ED372_RS07590	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
L63ED372_RS07600	COG0359	binds to the 23S rRNA
L63ED372_RS07605	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
L63ED372_RS07610	COG2965	DNA replication, synthesis of RNA primer
L63ED372_RS07615	COG0360	Binds together with S18 to 16S ribosomal RNA
L63ED372_RS07620	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L63ED372_RS07630	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
L63ED372_RS07635	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
L63ED372_RS07645	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
L63ED372_RS07650	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
L63ED372_RS07655	COG1534	Rna-binding protein
L63ED372_RS07660	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
L63ED372_RS07665	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
L63ED372_RS07670	COG0505	Belongs to the CarA family
L63ED372_RS07675	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
L63ED372_RS07680	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
L63ED372_RS07685	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
L63ED372_RS07690	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
L63ED372_RS07695	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
L63ED372_RS07700	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
L63ED372_RS07715	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
L63ED372_RS07720	COG0575	Belongs to the CDS family
L63ED372_RS07725	COG0233	cytoplasmic translational termination
L63ED372_RS07730	COG0528	UMP kinase activity
L63ED372_RS07735	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
L63ED372_RS07740	COG0052	Belongs to the universal ribosomal protein uS2 family
L63ED372_RS07750	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
L63ED372_RS07750	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
L63ED372_RS07755	COG0557	exoribonuclease II activity
L63ED372_RS07765	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
L63ED372_RS07770	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
L63ED372_RS07785	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
L63ED372_RS07790	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
L63ED372_RS07795	COG0436	Aminotransferase
L63ED372_RS07800	COG0824	Thioesterase
L63ED372_RS07840	COG1741	Belongs to the pirin family
L63ED372_RS07850	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
L63ED372_RS07855	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
L63ED372_RS07885	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
L63ED372_RS07890	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L63ED372_RS07905	COG4206	TonB-dependent receptor
L63ED372_RS07920	COG0730	response to heat
L63ED372_RS07935	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
L63ED372_RS07970	COG3278	Belongs to the heme-copper respiratory oxidase family
L63ED372_RS07980	COG2217	Heavy metal translocating P-type atpase
L63ED372_RS07985	COG0589	response to stress
L63ED372_RS07995	COG0318	PFAM AMP-dependent synthetase and ligase
L63ED372_RS08010	COG5441	Belongs to the UPF0261 family
L63ED372_RS08020	COG1012	belongs to the aldehyde dehydrogenase family
L63ED372_RS08030	COG0174	glutamine synthetase
L63ED372_RS08040	COG0518	GMP synthase (glutamine-hydrolyzing) activity
L63ED372_RS08040	COG0519	Catalyzes the synthesis of GMP from XMP
L63ED372_RS08055	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
L63ED372_RS08060	COG0129	dihydroxy-acid dehydratase activity
L63ED372_RS08065	COG3193	protein, possibly involved in utilization of glycolate and propanediol
L63ED372_RS08070	COG0670	Belongs to the BI1 family
L63ED372_RS08075	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
L63ED372_RS08085	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
L63ED372_RS08090	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
L63ED372_RS08100	COG1028	Short-chain dehydrogenase reductase Sdr
L63ED372_RS08115	COG0037	tRNA processing
L63ED372_RS08120	COG0825	malonyl-CoA metabolic process
L63ED372_RS08130	COG0215	cysteine-tRNA ligase activity
L63ED372_RS08150	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
L63ED372_RS08160	COG0741	lytic transglycosylase activity
L63ED372_RS08165	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
L63ED372_RS08170	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
L63ED372_RS08175	COG4970	Tfp pilus assembly protein FimT
L63ED372_RS08200	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
L63ED372_RS08200	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
L63ED372_RS08205	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
L63ED372_RS08210	COG0167	dihydroorotate dehydrogenase activity
L63ED372_RS08225	COG0579	oxidoreductase
L63ED372_RS08230	COG1028	Short-chain dehydrogenase reductase Sdr
L63ED372_RS08235	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
L63ED372_RS08240	COG1570	exodeoxyribonuclease VII activity
L63ED372_RS08245	COG0811	peptide transport
L63ED372_RS08250	COG0848	biopolymer transport protein
L63ED372_RS08255	COG1663	tetraacyldisaccharide 4'-kinase activity
L63ED372_RS08260	COG2835	tetraacyldisaccharide 4'-kinase activity
L63ED372_RS08265	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
L63ED372_RS08270	COG0563	adenylate kinase activity
L63ED372_RS08275	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
L63ED372_RS08285	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
L63ED372_RS08290	COG1250	3-hydroxyacyl-CoA dehydrogenase
L63ED372_RS08295	COG1024	Enoyl-CoA hydratase
L63ED372_RS08300	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
L63ED372_RS08315	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
L63ED372_RS08325	COG2833	Protein of unknown function (DUF455)
L63ED372_RS08330	COG4974	Belongs to the 'phage' integrase family
L63ED372_RS08335	COG3181	Tripartite tricarboxylate transporter family receptor
L63ED372_RS08345	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
L63ED372_RS08355	COG0860	N-Acetylmuramoyl-L-alanine amidase
L63ED372_RS08360	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
L63ED372_RS08385	COG1172	Belongs to the binding-protein-dependent transport system permease family
L63ED372_RS08390	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
L63ED372_RS08395	COG0436	Aminotransferase
L63ED372_RS08405	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
L63ED372_RS08410	COG1074	ATP-dependent DNA helicase activity
L63ED372_RS08415	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
L63ED372_RS08430	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L63ED372_RS08435	COG0318	PFAM AMP-dependent synthetase and ligase
L63ED372_RS08440	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L63ED372_RS08450	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
L63ED372_RS08460	COG0438	transferase activity, transferring glycosyl groups
L63ED372_RS08465	COG0679	Auxin Efflux Carrier
L63ED372_RS08485	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
L63ED372_RS08495	COG0121	glutamine amidotransferase
L63ED372_RS08500	COG1794	racemase activity, acting on amino acids and derivatives
L63ED372_RS08505	COG1522	sequence-specific DNA binding
L63ED372_RS08510	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
L63ED372_RS08520	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
L63ED372_RS08525	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L63ED372_RS08525	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
L63ED372_RS08530	COG0069	glutamate synthase activity
L63ED372_RS08560	COG0175	sulfate reduction
L63ED372_RS08570	COG2895	sulfate adenylyltransferase (ATP) activity
L63ED372_RS08580	COG0492	ferredoxin-NADP+ reductase activity
L63ED372_RS08600	COG0300	oxidoreductase activity
L63ED372_RS08625	COG2824	Alkylphosphonate utilization operon protein PhnA
L63ED372_RS08665	COG1558	bacterial-type flagellum-dependent cell motility
L63ED372_RS08670	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
L63ED372_RS08675	COG4786	Flagellar basal body rod
L63ED372_RS08675	COG4786	Flagellar basal body rod
L63ED372_RS08680	COG4787	bacterial-type flagellum-dependent cell motility
L63ED372_RS08695	COG1706	bacterial-type flagellum-dependent cell motility
L63ED372_RS08705	COG1256	bacterial-type flagellum assembly
L63ED372_RS08710	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
L63ED372_RS08770	COG0840	transmembrane signaling receptor activity
L63ED372_RS08775	COG0835	chemotaxis
L63ED372_RS08780	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
L63ED372_RS08785	COG2201	protein-glutamate methylesterase activity
L63ED372_RS08790	COG2201	protein-glutamate methylesterase activity
L63ED372_RS08795	COG0643	Histidine kinase
L63ED372_RS08795	COG0784	Response regulator, receiver
L63ED372_RS08795	COG2198	Histidine kinase
L63ED372_RS08810	COG1334	flagellar protein FlaG
L63ED372_RS08815	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
L63ED372_RS08820	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
L63ED372_RS08850	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
L63ED372_RS08875	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
L63ED372_RS08890	COG0840	transmembrane signaling receptor activity
L63ED372_RS08905	COG3290	protein histidine kinase activity
L63ED372_RS08905	COG0840	transmembrane signaling receptor activity
L63ED372_RS08935	COG1414	Transcriptional regulator
L63ED372_RS08940	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L63ED372_RS08945	COG0586	Pfam SNARE associated Golgi protein
L63ED372_RS08950	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
L63ED372_RS08955	COG2814	Major facilitator Superfamily
L63ED372_RS08960	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
L63ED372_RS08975	COG1051	belongs to the nudix hydrolase family
L63ED372_RS08985	COG1007	ATP synthesis coupled electron transport
L63ED372_RS09000	COG0713	ATP synthesis coupled electron transport
L63ED372_RS09010	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
L63ED372_RS09015	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
L63ED372_RS09020	COG1034	ATP synthesis coupled electron transport
L63ED372_RS09035	COG0649	NAD binding
L63ED372_RS09040	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
L63ED372_RS09045	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
L63ED372_RS09050	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
L63ED372_RS09065	COG0149	triose-phosphate isomerase activity
L63ED372_RS09070	COG3321	synthase
L63ED372_RS09070	COG1028	Short-chain dehydrogenase reductase Sdr
L63ED372_RS09070	COG0604	alcohol dehydrogenase
L63ED372_RS09075	COG1185	polyribonucleotide nucleotidyltransferase activity
L63ED372_RS09080	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
L63ED372_RS09095	COG0165	Argininosuccinate lyase
L63ED372_RS09110	COG0778	Nitroreductase
L63ED372_RS09135	COG0633	Ferredoxin
L63ED372_RS09155	COG0174	glutamine synthetase
L63ED372_RS09190	COG1187	pseudouridine synthase activity
L63ED372_RS09220	COG1028	Short-chain dehydrogenase reductase Sdr
L63ED372_RS09225	COG0183	Belongs to the thiolase family
L63ED372_RS09230	COG0251	oxidation-reduction process
L63ED372_RS09235	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
L63ED372_RS09240	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
L63ED372_RS09245	COG0667	Aldo Keto reductase
L63ED372_RS09250	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L63ED372_RS09255	COG2267	carboxylic ester hydrolase activity
L63ED372_RS09265	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
L63ED372_RS09270	COG0308	aminopeptidase N
L63ED372_RS09275	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
L63ED372_RS09295	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
L63ED372_RS09300	COG1162	GTPase activity
L63ED372_RS09305	COG2154	pterin-4-alpha-carbinolamine dehydratase
L63ED372_RS09310	COG0501	Belongs to the peptidase M48B family
L63ED372_RS09315	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
L63ED372_RS09320	COG0513	Belongs to the DEAD box helicase family
L63ED372_RS09325	COG0335	large ribosomal subunit rRNA binding
L63ED372_RS09330	COG0336	Belongs to the RNA methyltransferase TrmD family
L63ED372_RS09335	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
L63ED372_RS09340	COG0228	four-way junction DNA binding
L63ED372_RS09360	COG0617	tRNA 3'-terminal CCA addition
L63ED372_RS09370	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
L63ED372_RS09375	COG0628	permease
L63ED372_RS09380	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
L63ED372_RS09390	COG0728	peptidoglycan biosynthetic process
L63ED372_RS09395	COG0268	Binds directly to 16S ribosomal RNA
L63ED372_RS09405	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
L63ED372_RS09410	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
L63ED372_RS09420	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
L63ED372_RS09430	COG3483	tryptophan 2,3-dioxygenase activity
L63ED372_RS09445	COG2951	lytic endotransglycosylase activity
L63ED372_RS09465	COG0667	Aldo Keto reductase
L63ED372_RS09470	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
L63ED372_RS09480	COG3268	Saccharopine dehydrogenase
L63ED372_RS09485	COG1049	propionate catabolic process, 2-methylcitrate cycle
L63ED372_RS09500	COG0039	L-malate dehydrogenase activity
L63ED372_RS09505	COG2188	Transcriptional regulator
L63ED372_RS09510	COG2009	succinate dehydrogenase
L63ED372_RS09520	COG1053	succinate dehydrogenase
L63ED372_RS09525	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
L63ED372_RS09530	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
L63ED372_RS09535	COG0372	Belongs to the citrate synthase family
L63ED372_RS09545	COG2135	peptidase activity
L63ED372_RS09595	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
L63ED372_RS09600	COG0789	Transcriptional regulator
L63ED372_RS09625	COG2010	Cytochrome c
L63ED372_RS09675	COG2855	membrane
L63ED372_RS09765	COG0633	Ferredoxin
L63ED372_RS09770	COG0443	Heat shock 70 kDa protein
L63ED372_RS09785	COG0822	iron-sulfur transferase activity
L63ED372_RS09790	COG1104	cysteine desulfurase activity
L63ED372_RS09795	COG1959	2 iron, 2 sulfur cluster binding
L63ED372_RS09800	COG0556	nucleotide-excision repair
L63ED372_RS09815	COG2878	Part of a membrane complex involved in electron transport
L63ED372_RS09825	COG4770	biotin carboxylase activity
L63ED372_RS09830	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
L63ED372_RS09835	COG1703	isobutyryl-CoA mutase activity
L63ED372_RS09840	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
L63ED372_RS09840	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
L63ED372_RS09845	COG1802	Transcriptional regulator
L63ED372_RS09865	COG1028	Short-chain dehydrogenase reductase Sdr
L63ED372_RS09870	COG0183	Belongs to the thiolase family
L63ED372_RS09875	COG3243	poly(R)-hydroxyalkanoic acid synthase
L63ED372_RS09890	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
L63ED372_RS09895	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
L63ED372_RS09900	COG1414	Transcriptional regulator
L63ED372_RS09910	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
L63ED372_RS09915	COG1183	phosphatidylcholine synthase activity
L63ED372_RS09920	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
L63ED372_RS09925	COG0440	acetolactate synthase activity
L63ED372_RS09930	COG0028	Belongs to the TPP enzyme family
L63ED372_RS09960	COG0347	Belongs to the P(II) protein family
L63ED372_RS09965	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
L63ED372_RS09965	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
L63ED372_RS09975	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
L63ED372_RS09980	COG1012	belongs to the aldehyde dehydrogenase family
L63ED372_RS09985	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
L63ED372_RS09990	COG0746	molybdenum cofactor guanylyltransferase activity
L63ED372_RS09995	COG0303	'Molybdopterin
L63ED372_RS10000	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
L63ED372_RS10010	COG0328	RNA-DNA hybrid ribonuclease activity
L63ED372_RS10020	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L63ED372_RS10025	COG1388	LysM domain
L63ED372_RS10025	COG0741	lytic transglycosylase activity
L63ED372_RS10035	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
L63ED372_RS10040	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
L63ED372_RS10045	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
L63ED372_RS10075	COG3181	Tripartite tricarboxylate transporter family receptor
L63ED372_RS10080	COG2721	sulfolactate sulfo-lyase activity
L63ED372_RS10085	COG4948	Mandelate Racemase Muconate Lactonizing
L63ED372_RS10100	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
L63ED372_RS10110	COG2186	Transcriptional regulator
L63ED372_RS10115	COG4948	Mandelate Racemase Muconate Lactonizing
L63ED372_RS10120	COG2084	Dehydrogenase
L63ED372_RS10130	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
L63ED372_RS10135	COG1304	FMN binding
L63ED372_RS10140	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
L63ED372_RS10145	COG1024	Enoyl-CoA hydratase
L63ED372_RS10145	COG1250	3-hydroxyacyl-CoA dehydrogenase
L63ED372_RS10170	COG3093	addiction module antidote protein HigA
L63ED372_RS10175	COG1002	Type II restriction enzyme, methylase subunits
L63ED372_RS10215	COG4456	Virulence-associated protein
L63ED372_RS10220	COG1487	ribonuclease activity
L63ED372_RS10230	COG3177	Filamentation induced by cAMP protein fic
L63ED372_RS10250	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
L63ED372_RS10255	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
L63ED372_RS10270	COG2337	Toxic component of a toxin-antitoxin (TA) module
L63ED372_RS10290	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
L63ED372_RS10290	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
L63ED372_RS10295	COG3022	response to hydroperoxide
L63ED372_RS10300	COG0564	pseudouridine synthase activity
L63ED372_RS10305	COG1902	pentaerythritol trinitrate reductase activity
L63ED372_RS10325	COG0513	Belongs to the DEAD box helicase family
L63ED372_RS10335	COG0644	oxidoreductase
L63ED372_RS10345	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
L63ED372_RS10350	COG0254	rRNA binding
L63ED372_RS10360	COG0534	Mate efflux family protein
L63ED372_RS10370	COG0688	phosphatidylethanolamine metabolic process
L63ED372_RS10390	COG0477	Major facilitator Superfamily
L63ED372_RS10415	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
L63ED372_RS10420	COG0581	inorganic phosphate transmembrane transporter activity
L63ED372_RS10425	COG0573	inorganic phosphate transmembrane transporter activity
L63ED372_RS10470	COG1404	Belongs to the peptidase S8 family
L63ED372_RS10470	COG4935	Belongs to the peptidase S8 family
L63ED372_RS10485	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
L63ED372_RS10505	COG0798	PFAM Bile acid sodium symporter
L63ED372_RS10510	COG0248	Ppx GppA phosphatase
L63ED372_RS10525	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
L63ED372_RS10530	COG0438	transferase activity, transferring glycosyl groups
L63ED372_RS10550	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
L63ED372_RS10555	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
L63ED372_RS10560	COG3639	organic phosphonate transmembrane transporter activity
L63ED372_RS10565	COG1454	alcohol dehydrogenase
L63ED372_RS10565	COG1012	belongs to the aldehyde dehydrogenase family
L63ED372_RS10570	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L63ED372_RS10575	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
L63ED372_RS10585	COG2329	Antibiotic biosynthesis monooxygenase
L63ED372_RS10600	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
L63ED372_RS10625	COG0318	PFAM AMP-dependent synthetase and ligase
L63ED372_RS10635	COG1045	serine acetyltransferase
L63ED372_RS10645	COG0483	inositol monophosphate 1-phosphatase activity
L63ED372_RS10650	COG1253	flavin adenine dinucleotide binding
L63ED372_RS10655	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
L63ED372_RS10670	COG1804	L-carnitine dehydratase bile acid-inducible protein F
L63ED372_RS10675	COG1024	Enoyl-CoA hydratase
L63ED372_RS10690	COG1968	undecaprenyl-diphosphatase activity
L63ED372_RS10725	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
L63ED372_RS10850	COG1178	ABC-type Fe3 transport system permease component
L63ED372_RS10855	COG3842	ATPase activity
L63ED372_RS10875	COG0540	Belongs to the ATCase OTCase family
L63ED372_RS10880	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
L63ED372_RS10885	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
L63ED372_RS10890	COG1678	Uncharacterized ACR, COG1678
L63ED372_RS10895	COG0415	Belongs to the DNA photolyase family
L63ED372_RS10900	COG1773	rubredoxin
L63ED372_RS10910	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
L63ED372_RS10940	COG0513	Belongs to the DEAD box helicase family
L63ED372_RS10945	COG0138	bifunctional purine biosynthesis protein purh
L63ED372_RS10955	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
L63ED372_RS10960	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
L63ED372_RS10965	COG3181	Tripartite tricarboxylate transporter family receptor
L63ED372_RS10970	COG0235	Class ii aldolase
L63ED372_RS10975	COG3181	Tripartite tricarboxylate transporter family receptor
L63ED372_RS10980	COG3321	synthase
L63ED372_RS10980	COG1028	Short-chain dehydrogenase reductase Sdr
L63ED372_RS10980	COG0604	alcohol dehydrogenase
L63ED372_RS10985	COG1024	Enoyl-CoA hydratase
L63ED372_RS11010	COG0012	GTP binding
L63ED372_RS11015	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L63ED372_RS11040	COG2050	protein possibly involved in aromatic compounds catabolism
L63ED372_RS11045	COG1024	Enoyl-CoA hydratase
L63ED372_RS11055	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
L63ED372_RS11075	COG0437	4 iron, 4 sulfur cluster binding
L63ED372_RS11080	COG3383	formate dehydrogenase (NAD+) activity
L63ED372_RS11080	COG0243	molybdopterin cofactor binding
L63ED372_RS11100	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
L63ED372_RS11110	COG0437	4 iron, 4 sulfur cluster binding
L63ED372_RS11125	COG4191	Histidine kinase
L63ED372_RS11130	COG3383	formate dehydrogenase (NAD+) activity
L63ED372_RS11155	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
L63ED372_RS11170	COG2205	protein histidine kinase activity
L63ED372_RS11170	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L63ED372_RS11175	COG0489	protein tyrosine kinase activity
L63ED372_RS11185	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L63ED372_RS11185	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L63ED372_RS11190	COG0659	secondary active sulfate transmembrane transporter activity
L63ED372_RS11205	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
L63ED372_RS11210	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
L63ED372_RS11220	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
L63ED372_RS11225	COG3150	esterase
L63ED372_RS11230	COG3158	transport of potassium into the cell
L63ED372_RS11240	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
L63ED372_RS11255	COG0495	leucyl-tRNA aminoacylation
L63ED372_RS11270	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
L63ED372_RS11275	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
L63ED372_RS11280	COG0735	belongs to the Fur family
L63ED372_RS11285	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
L63ED372_RS11295	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
L63ED372_RS11315	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
L63ED372_RS11320	COG0318	PFAM AMP-dependent synthetase and ligase
L63ED372_RS11325	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
L63ED372_RS11330	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
L63ED372_RS11355	COG1696	Membrane protein involved in D-alanine export
L63ED372_RS11365	COG0482	sulfurtransferase activity
L63ED372_RS11375	COG3976	FMN-binding domain protein
L63ED372_RS11375	COG1053	succinate dehydrogenase
L63ED372_RS11380	COG1028	Short-chain dehydrogenase reductase Sdr
L63ED372_RS11400	COG0629	single-stranded DNA binding
L63ED372_RS11405	COG2814	Major facilitator Superfamily
L63ED372_RS11450	COG1960	acyl-CoA dehydrogenase activity
L63ED372_RS11460	COG2814	Major facilitator Superfamily
L63ED372_RS11465	COG0284	orotidine-5'-phosphate decarboxylase activity
L63ED372_RS11475	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
L63ED372_RS11490	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
L63ED372_RS11495	COG1181	Belongs to the D-alanine--D-alanine ligase family
L63ED372_RS11500	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
L63ED372_RS11505	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
L63ED372_RS11510	COG0772	Belongs to the SEDS family
L63ED372_RS11515	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
L63ED372_RS11520	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
L63ED372_RS11525	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
L63ED372_RS11530	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
L63ED372_RS11540	COG3116	cell division
L63ED372_RS11545	COG0275	rRNA processing
L63ED372_RS11550	COG2001	Belongs to the MraZ family
L63ED372_RS11565	COG0523	cobalamin synthesis protein
L63ED372_RS11570	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
L63ED372_RS11580	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
L63ED372_RS11585	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L63ED372_RS11595	COG1959	2 iron, 2 sulfur cluster binding
L63ED372_RS11610	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
L63ED372_RS11615	COG4628	conserved protein (DUF2132)
L63ED372_RS11630	COG1522	sequence-specific DNA binding
L63ED372_RS11635	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
L63ED372_RS11655	COG1194	a g-specific adenine glycosylase
L63ED372_RS11660	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
L63ED372_RS11670	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
L63ED372_RS11675	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
L63ED372_RS11685	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
L63ED372_RS11690	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
L63ED372_RS11695	COG0193	aminoacyl-tRNA hydrolase activity
L63ED372_RS11700	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
L63ED372_RS11705	COG0613	PHP domain protein
L63ED372_RS11715	COG0009	L-threonylcarbamoyladenylate synthase
L63ED372_RS11725	COG0247	lactate metabolic process
L63ED372_RS11730	COG1592	Rubrerythrin
L63ED372_RS11735	COG0525	valine-tRNA ligase activity
L63ED372_RS11745	COG0425	Belongs to the sulfur carrier protein TusA family
L63ED372_RS11805	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
L63ED372_RS11810	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
L63ED372_RS11815	COG1674	ftsk spoiiie
L63ED372_RS11820	COG0492	ferredoxin-NADP+ reductase activity
L63ED372_RS11825	COG0227	Belongs to the bacterial ribosomal protein bL28 family
L63ED372_RS11830	COG0267	Belongs to the bacterial ribosomal protein bL33 family
L63ED372_RS11840	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
L63ED372_RS11840	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
L63ED372_RS11850	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
L63ED372_RS11855	COG1960	acyl-CoA dehydrogenase activity
L63ED372_RS11875	COG0196	riboflavin kinase activity
L63ED372_RS11880	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
L63ED372_RS11885	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
L63ED372_RS11890	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
L63ED372_RS11895	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
L63ED372_RS11915	COG1028	Short-chain dehydrogenase reductase Sdr
L63ED372_RS11920	COG0697	spore germination
L63ED372_RS11945	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
L63ED372_RS11950	COG0084	hydrolase, TatD family'
L63ED372_RS11955	COG1136	(ABC) transporter
L63ED372_RS11975	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
L63ED372_RS11980	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
L63ED372_RS11985	COG0742	ribosomal rna small subunit methyltransferase
L63ED372_RS11990	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L63ED372_RS12000	COG0612	Peptidase, M16
L63ED372_RS12005	COG0612	Peptidase, M16
L63ED372_RS12015	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
L63ED372_RS12020	COG3181	Tripartite tricarboxylate transporter family receptor
L63ED372_RS12025	COG1999	signal sequence binding
L63ED372_RS12030	COG0109	protoheme IX farnesyltransferase activity
L63ED372_RS12065	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
L63ED372_RS12070	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
L63ED372_RS12085	COG2226	methyltransferase
L63ED372_RS12090	COG1040	competence protein
L63ED372_RS12095	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
L63ED372_RS12110	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
L63ED372_RS12125	COG2916	Histone family protein nucleoid-structuring protein H-NS
L63ED372_RS12130	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
L63ED372_RS12145	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
L63ED372_RS12160	COG0252	asparaginase activity
L63ED372_RS12180	COG0625	glutathione transferase activity
L63ED372_RS12190	COG0456	acetyltransferase
L63ED372_RS12200	COG1053	succinate dehydrogenase
L63ED372_RS12220	COG0066	3-isopropylmalate dehydratase activity
L63ED372_RS12225	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
L63ED372_RS12230	COG3181	Tripartite tricarboxylate transporter family receptor
L63ED372_RS12260	COG2188	Transcriptional regulator
L63ED372_RS12275	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
L63ED372_RS12285	COG4638	Rieske (2fe-2S)
L63ED372_RS12300	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
L63ED372_RS12325	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
L63ED372_RS12340	COG2264	protein methyltransferase activity
L63ED372_RS12345	COG0439	Biotin carboxylase
L63ED372_RS12350	COG0511	ligase activity, forming carbon-carbon bonds
L63ED372_RS12355	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
L63ED372_RS12365	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
L63ED372_RS12370	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
L63ED372_RS12375	COG0312	modulator of DNA gyrase
L63ED372_RS12380	COG2084	Dehydrogenase
L63ED372_RS12385	COG0772	Belongs to the SEDS family
L63ED372_RS12390	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
L63ED372_RS12395	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
L63ED372_RS12400	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
L63ED372_RS12410	COG0588	phosphoglycerate mutase activity
L63ED372_RS12415	COG0793	Belongs to the peptidase S41A family
L63ED372_RS12420	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
L63ED372_RS12425	COG1525	nuclease
L63ED372_RS12435	COG3181	Tripartite tricarboxylate transporter family receptor
L63ED372_RS12455	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
L63ED372_RS12465	COG0456	acetyltransferase
L63ED372_RS12495	COG0302	gtp cyclohydrolase
L63ED372_RS12500	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
L63ED372_RS12505	COG3568	Endonuclease Exonuclease Phosphatase
L63ED372_RS12510	COG0494	nUDIX hydrolase
L63ED372_RS12515	COG2198	Histidine kinase
L63ED372_RS12515	COG2205	protein histidine kinase activity
L63ED372_RS12515	COG0784	Response regulator, receiver
L63ED372_RS12525	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
L63ED372_RS12535	COG0724	RNA recognition motif
L63ED372_RS12540	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
L63ED372_RS12560	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
L63ED372_RS12575	COG2226	methyltransferase
L63ED372_RS12595	COG1175	transmembrane transport
L63ED372_RS12600	COG0395	ABC-type sugar transport system, permease component
L63ED372_RS12605	COG3842	ATPase activity
L63ED372_RS12610	COG0584	glycerophosphoryl diester phosphodiesterase
L63ED372_RS12620	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
L63ED372_RS12625	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
L63ED372_RS12630	COG2890	protein-(glutamine-N5) methyltransferase activity
L63ED372_RS12635	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
L63ED372_RS12645	COG1131	(ABC) transporter
L63ED372_RS12650	COG1725	Transcriptional regulator
L63ED372_RS12660	COG0442	prolyl-tRNA aminoacylation
L63ED372_RS12665	COG0494	nUDIX hydrolase
L63ED372_RS12670	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
L63ED372_RS12675	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
L63ED372_RS12680	COG0211	Belongs to the bacterial ribosomal protein bL27 family
L63ED372_RS12685	COG0261	This protein binds to 23S rRNA in the presence of protein L20
L63ED372_RS12690	COG0142	geranyltranstransferase activity
L63ED372_RS12705	COG1459	type II secretion system
L63ED372_RS12715	COG0237	dephospho-CoA kinase activity
L63ED372_RS12720	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
L63ED372_RS12725	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
L63ED372_RS12730	COG0494	nUDIX hydrolase
L63ED372_RS12740	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
L63ED372_RS12745	COG0653	protein targeting
L63ED372_RS12760	COG2969	positive regulation of protein catabolic process
L63ED372_RS12765	COG0625	glutathione transferase activity
L63ED372_RS12770	COG2857	Cytochrome c1
L63ED372_RS12775	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
L63ED372_RS12780	COG0723	plastoquinol--plastocyanin reductase activity
L63ED372_RS12785	COG1970	mechanosensitive ion channel activity
L63ED372_RS12790	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
L63ED372_RS12795	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
L63ED372_RS12800	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L63ED372_RS12805	COG0805	protein transport
L63ED372_RS12810	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
L63ED372_RS12815	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
L63ED372_RS12820	COG0537	adenosine 5'-monophosphoramidase activity
L63ED372_RS12830	COG0140	phosphoribosyl-ATP diphosphatase activity
L63ED372_RS12835	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
L63ED372_RS12840	COG4115	mRNA cleavage
L63ED372_RS12845	COG2161	toxin-antitoxin pair type II binding
L63ED372_RS12855	COG0107	imidazoleglycerol-phosphate synthase activity
L63ED372_RS12865	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
L63ED372_RS12875	COG0131	Imidazoleglycerol-phosphate dehydratase
L63ED372_RS12880	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
L63ED372_RS12885	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
L63ED372_RS12890	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
L63ED372_RS12895	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
L63ED372_RS12900	COG5007	Belongs to the BolA IbaG family
L63ED372_RS12905	COG0842	Transport permease protein
L63ED372_RS12910	COG1131	(ABC) transporter
L63ED372_RS12925	COG2853	Lipoprotein
L63ED372_RS12930	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
L63ED372_RS12935	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
L63ED372_RS12940	COG1127	ABC transporter
L63ED372_RS12950	COG0070	glutamate synthase
L63ED372_RS12950	COG0069	glutamate synthase activity
L63ED372_RS12950	COG0067	glutamate synthase
L63ED372_RS12995	COG0232	Belongs to the dGTPase family. Type 2 subfamily
L63ED372_RS13000	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
L63ED372_RS13005	COG0179	Fumarylacetoacetate (FAA) hydrolase
L63ED372_RS13010	COG1028	Short-chain dehydrogenase reductase Sdr
L63ED372_RS13015	COG1028	Short-chain dehydrogenase reductase Sdr
L63ED372_RS13020	COG4948	Mandelate Racemase Muconate Lactonizing
L63ED372_RS13025	COG2186	Transcriptional regulator
L63ED372_RS13030	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
L63ED372_RS13040	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
L63ED372_RS13045	COG2721	sulfolactate sulfo-lyase activity
L63ED372_RS13050	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
L63ED372_RS13055	COG0246	Mannitol dehydrogenase
L63ED372_RS13060	COG4948	Mandelate Racemase Muconate Lactonizing
L63ED372_RS13065	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
L63ED372_RS13070	COG2814	Major facilitator Superfamily
L63ED372_RS13075	COG2267	carboxylic ester hydrolase activity
L63ED372_RS13090	COG3608	succinylglutamate desuccinylase aspartoacylase
L63ED372_RS13090	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
L63ED372_RS13105	COG3622	Belongs to the hyi family
L63ED372_RS13110	COG0235	Class ii aldolase
L63ED372_RS13115	COG3395	kinase activity
L63ED372_RS13120	COG2084	Dehydrogenase
L63ED372_RS13130	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
L63ED372_RS13140	COG1028	Short-chain dehydrogenase reductase Sdr
L63ED372_RS13190	COG2353	YceI-like domain
L63ED372_RS13200	COG3038	cytochrome b561
L63ED372_RS13205	COG3384	dioxygenase
L63ED372_RS13210	COG0583	DNA-binding transcription factor activity
L63ED372_RS13220	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
L63ED372_RS13240	COG3040	lipid binding
L63ED372_RS13245	COG1028	Short-chain dehydrogenase reductase Sdr
L63ED372_RS13260	COG2186	Transcriptional regulator
L63ED372_RS13275	COG0346	lactoylglutathione lyase activity
L63ED372_RS13290	COG3181	Tripartite tricarboxylate transporter family receptor
L63ED372_RS13295	COG1804	L-carnitine dehydratase bile acid-inducible protein F
L63ED372_RS13300	COG2301	Belongs to the HpcH HpaI aldolase family
L63ED372_RS13310	COG2814	Major facilitator Superfamily
L63ED372_RS13315	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
L63ED372_RS13315	COG2813	Specifically methylates the guanine in position
L63ED372_RS13320	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
L63ED372_RS13325	COG2119	membrane
L63ED372_RS13330	COG0004	ammonium transporteR
L63ED372_RS13335	COG0724	RNA recognition motif
L63ED372_RS13345	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
L63ED372_RS13360	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
L63ED372_RS13370	COG4214	carbohydrate transport
L63ED372_RS13375	COG0559	Belongs to the binding-protein-dependent transport system permease family
L63ED372_RS13395	COG0318	PFAM AMP-dependent synthetase and ligase
L63ED372_RS13400	COG1028	Short-chain dehydrogenase reductase Sdr
L63ED372_RS13425	COG0179	Fumarylacetoacetate (FAA) hydrolase
L63ED372_RS13440	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
L63ED372_RS13445	COG0706	membrane insertase activity
L63ED372_RS13450	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
L63ED372_RS13455	COG0594	ribonuclease P activity
L63ED372_RS13460	COG0230	Belongs to the bacterial ribosomal protein bL34 family
L63ED372_RS13470	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
L63ED372_RS13475	COG0592	DNA-directed DNA polymerase activity
L63ED372_RS13485	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
L63ED372_RS13510	COG0343	queuine tRNA-ribosyltransferase activity
L63ED372_RS13530	COG4208	sulfate ABC transporter
L63ED372_RS13535	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
L63ED372_RS13540	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
L63ED372_RS13545	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
L63ED372_RS13550	COG2175	clavaminate synthase activity
L63ED372_RS13610	COG4772	TonB-dependent receptor
L63ED372_RS13615	COG0625	glutathione transferase activity
L63ED372_RS13630	COG0768	penicillin binding
L63ED372_RS13640	COG1792	Involved in formation and maintenance of cell shape
L63ED372_RS13645	COG1077	Cell shape determining protein MreB Mrl
L63ED372_RS13650	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
L63ED372_RS13655	COG0154	amidase activity
L63ED372_RS13660	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
L63ED372_RS13705	COG3180	Ammonia monooxygenase
L63ED372_RS13710	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
L63ED372_RS13720	COG0583	DNA-binding transcription factor activity
L63ED372_RS13725	COG0277	FAD linked oxidase domain protein
L63ED372_RS13735	COG2070	2-Nitropropane dioxygenase
L63ED372_RS13740	COG3437	response regulator, receiver
L63ED372_RS13740	COG3850	Histidine kinase
L63ED372_RS13740	COG4999	Histidine kinase
L63ED372_RS13740	COG2205	protein histidine kinase activity
L63ED372_RS13745	COG1846	Transcriptional regulator
L63ED372_RS13760	COG1012	belongs to the aldehyde dehydrogenase family
L63ED372_RS13770	COG3384	dioxygenase
L63ED372_RS13780	COG3971	2-oxopent-4-enoate hydratase activity
L63ED372_RS13795	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
L63ED372_RS13805	COG2084	Dehydrogenase
L63ED372_RS13825	COG2823	Periplasmic or secreted lipoprotein
L63ED372_RS13830	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
L63ED372_RS13835	COG0792	nuclease activity
L63ED372_RS13840	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
L63ED372_RS13860	COG2205	protein histidine kinase activity
L63ED372_RS13865	COG0745	RESPONSE REGULATOR receiver
L63ED372_RS13870	COG2211	Major facilitator Superfamily
L63ED372_RS13880	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L63ED372_RS13885	COG2264	protein methyltransferase activity
L63ED372_RS13890	COG0708	Exodeoxyribonuclease III
L63ED372_RS13895	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
L63ED372_RS13910	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L63ED372_RS13945	COG0355	proton-transporting ATP synthase activity, rotational mechanism
L63ED372_RS13950	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
L63ED372_RS13955	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
L63ED372_RS13960	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
L63ED372_RS13965	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
L63ED372_RS13970	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
L63ED372_RS13980	COG0356	it plays a direct role in the translocation of protons across the membrane
L63ED372_RS13995	COG2921	Belongs to the UPF0250 family
L63ED372_RS14000	COG0321	lipoyl(octanoyl) transferase activity
L63ED372_RS14005	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
L63ED372_RS14015	COG0625	glutathione transferase activity
L63ED372_RS14020	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
L63ED372_RS14025	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
L63ED372_RS14060	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
L63ED372_RS14065	COG3909	cytochrome
L63ED372_RS14075	COG0456	acetyltransferase
L63ED372_RS14080	COG0678	peroxiredoxin activity
L63ED372_RS14085	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
L63ED372_RS14090	COG0255	Belongs to the universal ribosomal protein uL29 family
L63ED372_RS14095	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
L63ED372_RS14100	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
L63ED372_RS14105	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
L63ED372_RS14110	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
L63ED372_RS14115	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
L63ED372_RS14120	COG0089	rRNA binding
L63ED372_RS14125	COG0088	Forms part of the polypeptide exit tunnel
L63ED372_RS14130	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
L63ED372_RS14135	COG0051	transcription antitermination factor activity, RNA binding
L63ED372_RS14140	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
L63ED372_RS14145	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
L63ED372_RS14150	COG0049	tRNA binding
L63ED372_RS14155	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
L63ED372_RS14160	COG1686	Belongs to the peptidase S11 family
L63ED372_RS14165	COG2945	thiolester hydrolase activity
L63ED372_RS14180	COG1981	membrane
L63ED372_RS14190	COG0598	Magnesium transport protein CorA
L63ED372_RS14195	COG0412	Dienelactone hydrolase
L63ED372_RS14205	COG1028	Short-chain dehydrogenase reductase Sdr
L63ED372_RS14210	COG2030	dehydratase
L63ED372_RS14215	COG2095	MarC family integral membrane protein
L63ED372_RS14220	COG3609	addiction module antidote protein, CC2985 family
L63ED372_RS14250	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
L63ED372_RS14255	COG0586	Pfam SNARE associated Golgi protein
L63ED372_RS14265	COG0386	Belongs to the glutathione peroxidase family
L63ED372_RS14275	COG0247	lactate metabolic process
L63ED372_RS14280	COG0277	FAD linked oxidase domain protein
L63ED372_RS14305	COG0004	ammonium transporteR
L63ED372_RS14310	COG0347	Belongs to the P(II) protein family
L63ED372_RS14320	COG0606	chelatase, subunit chli
L63ED372_RS14330	COG2897	thiosulfate sulfurtransferase activity
L63ED372_RS14350	COG3639	organic phosphonate transmembrane transporter activity
L63ED372_RS14360	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
L63ED372_RS14370	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
L63ED372_RS14375	COG1262	PFAM Formylglycine-generating sulfatase enzyme
L63ED372_RS14385	COG0709	Synthesizes selenophosphate from selenide and ATP
L63ED372_RS14410	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
L63ED372_RS14440	COG0732	type I restriction modification DNA specificity domain
L63ED372_RS14455	COG2365	Tyrosine phosphatase family
L63ED372_RS14465	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
L63ED372_RS14490	COG1804	L-carnitine dehydratase bile acid-inducible protein F
L63ED372_RS14500	COG0443	Heat shock 70 kDa protein
L63ED372_RS14520	COG1832	CoA-binding protein
L63ED372_RS14540	COG0217	transcriptional regulatory protein
L63ED372_RS14545	COG3181	Tripartite tricarboxylate transporter family receptor
L63ED372_RS14560	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
L63ED372_RS14575	COG3842	ATPase activity
L63ED372_RS14590	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
L63ED372_RS14625	COG2723	6-phospho-beta-galactosidase activity
L63ED372_RS14630	COG0395	ABC-type sugar transport system, permease component
L63ED372_RS14670	COG3540	Alkaline phosphatase
L63ED372_RS14680	COG0604	alcohol dehydrogenase
L63ED372_RS14685	COG1686	Belongs to the peptidase S11 family
L63ED372_RS14690	COG0583	DNA-binding transcription factor activity
L63ED372_RS14695	COG2301	Belongs to the HpcH HpaI aldolase family
L63ED372_RS14710	COG1960	acyl-CoA dehydrogenase activity
L63ED372_RS14715	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
L63ED372_RS14720	COG0318	PFAM AMP-dependent synthetase and ligase
L63ED372_RS14740	COG1960	acyl-CoA dehydrogenase activity
L63ED372_RS14745	COG0183	Belongs to the thiolase family
L63ED372_RS14750	COG1028	Short-chain dehydrogenase reductase Sdr
L63ED372_RS14760	COG1024	Enoyl-CoA hydratase
L63ED372_RS14765	COG1028	Short-chain dehydrogenase reductase Sdr
L63ED372_RS14770	COG0318	PFAM AMP-dependent synthetase and ligase
L63ED372_RS14780	COG1028	Short-chain dehydrogenase reductase Sdr
L63ED372_RS14790	COG2030	dehydratase
L63ED372_RS14805	COG1804	L-carnitine dehydratase bile acid-inducible protein F
L63ED372_RS14810	COG0318	PFAM AMP-dependent synthetase and ligase
L63ED372_RS14815	COG2171	N-acyltransferase activity
L63ED372_RS14830	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L63ED372_RS14840	COG2096	Adenosyltransferase
L63ED372_RS14845	COG0277	FAD linked oxidase domain protein
L63ED372_RS14855	COG2909	trisaccharide binding
L63ED372_RS14860	COG3135	benzoate transporter
L63ED372_RS14870	COG0784	Response regulator, receiver
L63ED372_RS14870	COG2205	protein histidine kinase activity
L63ED372_RS14875	COG1475	DNA binding
L63ED372_RS14885	COG1192	Involved in chromosome partitioning
L63ED372_RS14900	COG0357	Ribosomal RNA small subunit methyltransferase G
L63ED372_RS14905	COG0445	tRNA wobble uridine modification
L63ED372_RS14920	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
L63ED372_RS14930	COG0850	regulation of cytokinetic process
L63ED372_RS14960	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
L63ED372_RS14965	COG1902	pentaerythritol trinitrate reductase activity
L63ED372_RS14995	COG0791	NLP P60 protein
L63ED372_RS15000	COG4566	intracellular signal transduction
L63ED372_RS15015	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
L63ED372_RS15035	COG2194	sulfuric ester hydrolase activity
L63ED372_RS15040	COG1028	Short-chain dehydrogenase reductase Sdr
L63ED372_RS15055	COG0583	DNA-binding transcription factor activity
L63ED372_RS15065	COG3046	protein related to deoxyribodipyrimidine photolyase
L63ED372_RS15085	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
L63ED372_RS15105	COG0300	oxidoreductase activity
L63ED372_RS15115	COG0625	glutathione transferase activity
L63ED372_RS15130	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
L63ED372_RS15135	COG0045	succinate-CoA ligase (ADP-forming) activity
L63ED372_RS15140	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
L63ED372_RS15145	COG0861	Integral membrane protein TerC family
L63ED372_RS15150	COG4969	Belongs to the N-Me-Phe pilin family
L63ED372_RS15165	COG4566	intracellular signal transduction
L63ED372_RS15170	COG0646	methionine synthase
L63ED372_RS15170	COG1410	methionine synthase
L63ED372_RS15185	COG1595	DNA-templated transcription, initiation
L63ED372_RS15195	COG3220	belongs to the UPF0276 family
L63ED372_RS15205	COG2259	Doxx family
L63ED372_RS15210	COG4134	Bacterial extracellular solute-binding protein
L63ED372_RS15215	COG4135	transport system, permease component
L63ED372_RS15220	COG4136	ATPase activity
L63ED372_RS15225	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
L63ED372_RS15255	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L63ED372_RS15280	COG1028	Short-chain dehydrogenase reductase Sdr
L63ED372_RS15295	COG3047	cAMP biosynthetic process
L63ED372_RS15300	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
L63ED372_RS15315	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
L63ED372_RS15320	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
L63ED372_RS15325	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
L63ED372_RS15330	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
L63ED372_RS15335	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
L63ED372_RS15340	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
L63ED372_RS15345	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
L63ED372_RS15350	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
L63ED372_RS15355	COG1841	ribosomal large subunit assembly
L63ED372_RS15360	COG0200	Binds to the 23S rRNA
L63ED372_RS15365	COG0201	protein transport
L63ED372_RS15370	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
L63ED372_RS15375	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
L63ED372_RS15380	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
L63ED372_RS15385	COG0202	RNA polymerase activity
L63ED372_RS15390	COG0203	ribosomal protein L17
L63ED372_RS15405	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
L63ED372_RS15415	COG2967	ApaG domain
L63ED372_RS15420	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
L63ED372_RS15425	COG0546	phosphoglycolate phosphatase activity
L63ED372_RS15435	COG0512	Glutamine amidotransferase of anthranilate synthase
L63ED372_RS15440	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
L63ED372_RS15445	COG1280	lysine exporter protein (LysE YggA)
L63ED372_RS15450	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
L63ED372_RS15455	COG0134	indole-3-glycerol-phosphate synthase activity
L63ED372_RS15460	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
L63ED372_RS15480	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
L63ED372_RS15500	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
L63ED372_RS15505	COG0081	regulation of translation
L63ED372_RS15510	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
L63ED372_RS15515	COG0222	ribosome binding
L63ED372_RS15520	COG0085	RNA polymerase activity
L63ED372_RS15525	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
L63ED372_RS15535	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
L63ED372_RS15535	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
L63ED372_RS15545	COG5000	phosphorelay sensor kinase activity
L63ED372_RS15550	COG2204	response regulator
L63ED372_RS15595	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
L63ED372_RS15685	COG0318	PFAM AMP-dependent synthetase and ligase
L63ED372_RS15695	COG4535	Mg2 and Co2 transporter CorC
L63ED372_RS15700	COG0815	Transfers the fatty acyl group on membrane lipoproteins
L63ED372_RS15705	COG0752	glycyl-tRNA synthetase alpha subunit
L63ED372_RS15710	COG0751	glycine-tRNA ligase activity
L63ED372_RS15715	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
L63ED372_RS15720	COG0204	Acyl-transferase
L63ED372_RS15735	COG0789	Transcriptional regulator
L63ED372_RS15745	COG1960	acyl-CoA dehydrogenase activity
L63ED372_RS15750	COG0288	reversible hydration of carbon dioxide
L63ED372_RS15760	COG0183	Belongs to the thiolase family
L63ED372_RS15770	COG1960	acyl-CoA dehydrogenase activity
L63ED372_RS15775	COG0569	domain protein
L63ED372_RS15790	COG3012	SEC-C Motif Domain Protein
L63ED372_RS15795	COG0346	lactoylglutathione lyase activity
L63ED372_RS15800	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
L63ED372_RS15805	COG2207	Transcriptional regulator
L63ED372_RS15810	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
L63ED372_RS15830	COG1024	Enoyl-CoA hydratase
L63ED372_RS15840	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
L63ED372_RS15870	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L63ED372_RS15910	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
L63ED372_RS15920	COG2264	protein methyltransferase activity
L63ED372_RS15930	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
L63ED372_RS15940	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
L63ED372_RS15945	COG1385	rRNA (uridine-N3-)-methyltransferase activity
L63ED372_RS15955	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
L63ED372_RS15960	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
L63ED372_RS15965	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
L63ED372_RS15980	COG0281	malic enzyme
L63ED372_RS15980	COG0280	phosphate acetyltransferase
L63ED372_RS15985	COG2258	MOSC domain
L63ED372_RS15990	COG0006	proline dipeptidase activity
L63ED372_RS15995	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
L63ED372_RS16005	COG0688	phosphatidylethanolamine metabolic process
L63ED372_RS16010	COG1131	(ABC) transporter
L63ED372_RS16015	COG0842	Transport permease protein
L63ED372_RS16025	COG1250	3-hydroxyacyl-CoA dehydrogenase
L63ED372_RS16030	COG1024	Enoyl-CoA hydratase
L63ED372_RS16040	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
L63ED372_RS16045	COG0837	glucose binding
L63ED372_RS16055	COG0326	Molecular chaperone. Has ATPase activity
L63ED372_RS16060	COG1840	ABC-type Fe3 transport system, periplasmic component
L63ED372_RS16080	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein