locus-tag	class	description
BUW47_RS00005	COG2261	transglycosylase associated protein
BUW47_RS00030	COG2801	Transposase and inactivated derivatives
BUW47_RS00035	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BUW47_RS00040	COG0358	DNA primase activity
BUW47_RS00045	COG0751	glycine-tRNA ligase activity
BUW47_RS00050	COG0752	glycyl-tRNA synthetase alpha subunit
BUW47_RS00055	COG1381	Involved in DNA repair and RecF pathway recombination
BUW47_RS00060	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
BUW47_RS00065	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
BUW47_RS00070	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
BUW47_RS00075	COG1702	phosphate starvation-inducible protein PhoH
BUW47_RS00080	COG1610	YqeY-like protein
BUW47_RS00085	COG0828	Belongs to the bacterial ribosomal protein bS21 family
BUW47_RS00095	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
BUW47_RS00100	COG0124	histidyl-tRNA synthetase
BUW47_RS00110	COG0860	N-Acetylmuramoyl-L-alanine amidase
BUW47_RS00115	COG3001	Fructosamine kinase
BUW47_RS00120	COG2040	homocysteine
BUW47_RS00125	COG0833	amino acid
BUW47_RS00130	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
BUW47_RS00135	COG0460	homoserine dehydrogenase
BUW47_RS00160	COG1126	abc transporter atp-binding protein
BUW47_RS00165	COG0765	amino acid transport
BUW47_RS00170	COG0765	amino acid transport
BUW47_RS00175	COG2079	MmgE PrpD family protein
BUW47_RS00180	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BUW47_RS00185	COG1473	amidohydrolase
BUW47_RS00190	COG1126	abc transporter atp-binding protein
BUW47_RS00195	COG0765	amino acid transport
BUW47_RS00200	COG0456	acetyltransferase
BUW47_RS00205	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BUW47_RS00210	COG0626	cystathionine gamma-synthase activity
BUW47_RS00215	COG0626	cystathionine gamma-synthase activity
BUW47_RS00225	COG1490	D-aminoacyl-tRNA deacylase activity
BUW47_RS00230	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BUW47_RS00240	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BUW47_RS00245	COG2264	protein methyltransferase activity
BUW47_RS00260	COG0039	L-malate dehydrogenase activity
BUW47_RS00275	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
BUW47_RS00280	COG0351	phosphomethylpyrimidine kinase
BUW47_RS00285	COG0352	thiamine-phosphate diphosphorylase activity
BUW47_RS00290	COG0351	phosphomethylpyrimidine kinase
BUW47_RS00305	COG0493	'glutamate synthase
BUW47_RS00310	COG0070	glutamate synthase
BUW47_RS00310	COG0069	glutamate synthase activity
BUW47_RS00310	COG0067	glutamate synthase
BUW47_RS00330	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BUW47_RS00335	COG1464	Belongs to the NlpA lipoprotein family
BUW47_RS00340	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BUW47_RS00345	COG1811	Na channel or pump
BUW47_RS00365	COG1104	cysteine desulfurase activity
BUW47_RS00375	COG0745	RESPONSE REGULATOR receiver
BUW47_RS00380	COG5002	protein histidine kinase activity
BUW47_RS00390	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BUW47_RS00390	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BUW47_RS00395	COG0307	riboflavin synthase, alpha
BUW47_RS00405	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
BUW47_RS00420	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BUW47_RS00425	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
BUW47_RS00430	COG0667	Aldo Keto reductase
BUW47_RS00435	COG0406	alpha-ribazole phosphatase activity
BUW47_RS00445	COG0481	GTPase activity
BUW47_RS00450	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BUW47_RS00455	COG0140	phosphoribosyl-ATP diphosphatase activity
BUW47_RS00460	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
BUW47_RS00465	COG0107	imidazoleglycerol-phosphate synthase activity
BUW47_RS00470	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
BUW47_RS00475	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
BUW47_RS00480	COG0131	Imidazoleglycerol-phosphate dehydratase
BUW47_RS00485	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
BUW47_RS00490	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
BUW47_RS00500	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
BUW47_RS00510	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
BUW47_RS00520	COG0484	heat shock protein binding
BUW47_RS00525	COG0443	Heat shock 70 kDa protein
BUW47_RS00530	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BUW47_RS00535	COG1420	regulation of RNA biosynthetic process
BUW47_RS00555	COG2801	Transposase and inactivated derivatives
BUW47_RS00565	COG1113	amino acid transport
BUW47_RS00575	COG3048	D-serine ammonia-lyase activity
BUW47_RS00585	COG3759	membrane
BUW47_RS00610	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BUW47_RS00640	COG2814	Major facilitator Superfamily
BUW47_RS00645	COG0196	riboflavin kinase activity
BUW47_RS00650	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
BUW47_RS00655	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
BUW47_RS00660	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
BUW47_RS00670	COG2740	Nucleic-acid-binding protein implicated in transcription termination
BUW47_RS00675	COG0195	Participates in both transcription termination and antitermination
BUW47_RS00680	COG0779	Required for maturation of 30S ribosomal subunits
BUW47_RS00685	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BUW47_RS00690	COG0505	Belongs to the CarA family
BUW47_RS00695	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
BUW47_RS00700	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
BUW47_RS00705	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BUW47_RS00710	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BUW47_RS00715	COG2176	DNA-directed DNA polymerase activity
BUW47_RS00720	COG0442	prolyl-tRNA aminoacylation
BUW47_RS00725	COG0750	zinc metalloprotease
BUW47_RS00730	COG4589	Belongs to the CDS family
BUW47_RS00735	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BUW47_RS00740	COG0233	cytoplasmic translational termination
BUW47_RS00750	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
BUW47_RS00755	COG0052	Belongs to the universal ribosomal protein uS2 family
BUW47_RS00760	COG2827	Endonuclease containing a URI domain
BUW47_RS00765	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
BUW47_RS00770	COG0204	Acyl-transferase
BUW47_RS00775	COG3763	UPF0154 protein
BUW47_RS00780	COG4224	UPF0291 protein
BUW47_RS00785	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
BUW47_RS00790	COG3425	synthase
BUW47_RS00795	COG0247	lactate metabolic process
BUW47_RS00800	COG1139	Iron-sulfur cluster binding protein
BUW47_RS00805	COG1556	Lactate utilization protein
BUW47_RS00825	COG2151	metal-sulfur cluster biosynthetic enzyme
BUW47_RS00830	COG1760	l-serine dehydratase
BUW47_RS00835	COG1760	l-serine dehydratase
BUW47_RS00880	COG2801	Transposase and inactivated derivatives
BUW47_RS00900	COG4106	trans-aconitate 2-methyltransferase activity
BUW47_RS00955	COG0531	amino acid
BUW47_RS01070	COG3728	DNA packaging
BUW47_RS01070	COG5484	DNA packaging
BUW47_RS01130	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BUW47_RS01245	COG3328	transposase activity
BUW47_RS01255	COG0367	asparagine synthase
BUW47_RS01270	COG1028	Short-chain dehydrogenase reductase Sdr
BUW47_RS01285	COG1396	sequence-specific DNA binding
BUW47_RS01305	COG2249	NAD(P)H dehydrogenase (quinone) activity
BUW47_RS01325	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BUW47_RS01335	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BUW47_RS01340	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
BUW47_RS01340	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
BUW47_RS01345	COG0300	oxidoreductase activity
BUW47_RS01350	COG1234	tRNA 3'-trailer cleavage
BUW47_RS01355	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BUW47_RS01360	COG0322	excinuclease ABC activity
BUW47_RS01365	COG1126	abc transporter atp-binding protein
BUW47_RS01375	COG0218	Necessary for normal cell division and for the maintenance of normal septation
BUW47_RS01380	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
BUW47_RS01385	COG0544	peptidyl-prolyl cis-trans isomerase activity
BUW47_RS01390	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BUW47_RS01410	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BUW47_RS01415	COG0268	Binds directly to 16S ribosomal RNA
BUW47_RS01420	COG1466	dna polymerase III delta subunit
BUW47_RS01425	COG0658	competence protein
BUW47_RS01425	COG2333	competence protein COMEC
BUW47_RS01430	COG2131	deaminase
BUW47_RS01435	COG1555	photosystem II stabilization
BUW47_RS01435	COG1596	polysaccharide export
BUW47_RS01440	COG3480	Lon protease (S16) C-terminal proteolytic domain
BUW47_RS01445	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
BUW47_RS01450	COG0742	ribosomal rna small subunit methyltransferase
BUW47_RS01465	COG1217	gtp-binding protein TYPA
BUW47_RS01470	COG0483	inositol monophosphate 1-phosphatase activity
BUW47_RS01475	COG4476	Belongs to the UPF0223 family
BUW47_RS01480	COG0242	peptide deformylase activity
BUW47_RS01500	COG5503	Protein of unknown function (DUF1447)
BUW47_RS01505	COG1597	lipid kinase activity
BUW47_RS01510	COG1393	Belongs to the ArsC family
BUW47_RS01515	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BUW47_RS01520	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BUW47_RS01530	COG0406	alpha-ribazole phosphatase activity
BUW47_RS01545	COG0482	sulfurtransferase activity
BUW47_RS01555	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BUW47_RS01570	COG1278	Cold shock
BUW47_RS01575	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
BUW47_RS01580	COG3599	regulation of cell shape
BUW47_RS01595	COG1799	cell septum assembly
BUW47_RS01600	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
BUW47_RS01605	COG0849	cell division
BUW47_RS01615	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BUW47_RS01620	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BUW47_RS01625	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BUW47_RS01630	COG0768	penicillin binding
BUW47_RS01640	COG0275	rRNA processing
BUW47_RS01645	COG2001	Belongs to the MraZ family
BUW47_RS01660	COG1674	ftsk spoiiie
BUW47_RS01670	COG0500	methyltransferase
BUW47_RS01675	COG2706	6-phosphogluconolactonase activity
BUW47_RS01680	COG0564	pseudouridine synthase activity
BUW47_RS01685	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BUW47_RS01690	COG2357	RelA SpoT domain protein
BUW47_RS01705	COG4862	establishment of competence for transformation
BUW47_RS01710	COG1393	Belongs to the ArsC family
BUW47_RS01830	COG0586	Pfam SNARE associated Golgi protein
BUW47_RS01840	COG0647	UMP catabolic process
BUW47_RS01845	COG4470	Protein conserved in bacteria
BUW47_RS01855	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
BUW47_RS01860	COG0827	DNA restriction-modification system
BUW47_RS01880	COG4537	Required for transformation and DNA binding
BUW47_RS01900	COG3942	CHAP domain
BUW47_RS01900	COG1388	LysM domain
BUW47_RS01945	COG0791	NLP P60 protein
BUW47_RS01945	COG1388	LysM domain
BUW47_RS02140	COG3646	Phage regulatory protein
BUW47_RS02140	COG3645	SOS response
BUW47_RS02150	COG1396	sequence-specific DNA binding
BUW47_RS02175	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
BUW47_RS02185	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BUW47_RS02195	COG0791	NLP P60 protein
BUW47_RS02195	COG1388	LysM domain
BUW47_RS02200	COG0217	transcriptional regulatory protein
BUW47_RS02210	COG1609	Transcriptional regulator
BUW47_RS02215	COG0006	proline dipeptidase activity
BUW47_RS02230	COG0668	transmembrane transport
BUW47_RS02235	COG0561	phosphatase activity
BUW47_RS02250	COG0622	Phosphoesterase
BUW47_RS02255	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
BUW47_RS02260	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
BUW47_RS02275	COG3118	belongs to the thioredoxin family
BUW47_RS02280	COG1193	negative regulation of DNA recombination
BUW47_RS02290	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BUW47_RS02295	COG3906	Belongs to the UPF0473 family
BUW47_RS02300	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
BUW47_RS02305	COG4472	Bacterial protein of unknown function (DUF965)
BUW47_RS02310	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BUW47_RS02315	COG0513	Belongs to the DEAD box helicase family
BUW47_RS02320	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
BUW47_RS02335	COG2255	four-way junction helicase activity
BUW47_RS02340	COG0632	four-way junction helicase activity
BUW47_RS02345	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
BUW47_RS02350	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
BUW47_RS02360	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
BUW47_RS02365	COG1058	Belongs to the CinA family
BUW47_RS02365	COG1546	Belongs to the CinA family
BUW47_RS02370	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BUW47_RS02375	COG1426	Protein conserved in bacteria
BUW47_RS02380	COG0612	Peptidase, M16
BUW47_RS02385	COG0612	Peptidase, M16
BUW47_RS02390	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BUW47_RS02395	COG1126	abc transporter atp-binding protein
BUW47_RS02400	COG0765	amino acid transport
BUW47_RS02410	COG1792	Involved in formation and maintenance of cell shape
BUW47_RS02415	COG1077	Cell shape determining protein MreB Mrl
BUW47_RS02425	COG0285	dihydrofolate synthase activity
BUW47_RS02430	COG0525	valine-tRNA ligase activity
BUW47_RS02435	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
BUW47_RS02465	COG1929	Belongs to the glycerate kinase type-1 family
BUW47_RS02470	COG2610	gluconate transmembrane transporter activity
BUW47_RS02475	COG0301	tRNA thio-modification
BUW47_RS02480	COG1104	cysteine desulfurase activity
BUW47_RS02485	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
BUW47_RS02490	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BUW47_RS02505	COG3942	CHAP domain
BUW47_RS02505	COG1388	LysM domain
BUW47_RS02570	COG5280	Phage tail tape measure protein TP901
BUW47_RS02570	COG3953	SLT domain
BUW47_RS02670	COG0629	single-stranded DNA binding
BUW47_RS02705	COG1396	sequence-specific DNA binding
BUW47_RS02740	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BUW47_RS02760	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BUW47_RS02770	COG0589	response to stress
BUW47_RS02785	COG1181	Belongs to the D-alanine--D-alanine ligase family
BUW47_RS02800	COG0772	Belongs to the SEDS family
BUW47_RS02810	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
BUW47_RS02815	COG1077	Cell shape determining protein MreB Mrl
BUW47_RS02820	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BUW47_RS02830	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BUW47_RS02835	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
BUW47_RS02840	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
BUW47_RS02845	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
BUW47_RS02850	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BUW47_RS02855	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BUW47_RS02860	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BUW47_RS02865	COG0356	it plays a direct role in the translocation of protons across the membrane
BUW47_RS02870	COG2233	PERMEase
BUW47_RS02885	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
BUW47_RS02890	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BUW47_RS02895	COG0009	L-threonylcarbamoyladenylate synthase
BUW47_RS02900	COG2890	protein-(glutamine-N5) methyltransferase activity
BUW47_RS02905	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BUW47_RS02910	COG1435	thymidine kinase activity
BUW47_RS02915	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BUW47_RS02920	COG3442	glutamine amidotransferase
BUW47_RS02935	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BUW47_RS02940	COG1132	(ABC) transporter
BUW47_RS02975	COG3527	Alpha-acetolactate decarboxylase
BUW47_RS02980	COG0149	triose-phosphate isomerase activity
BUW47_RS02985	COG0656	L-ascorbic acid biosynthetic process
BUW47_RS03015	COG0450	alkyl hydroperoxide reductase
BUW47_RS03050	COG2115	Belongs to the xylose isomerase family
BUW47_RS03065	COG4975	Glucose uptake
BUW47_RS03070	COG3850	Histidine kinase
BUW47_RS03070	COG5002	protein histidine kinase activity
BUW47_RS03075	COG0745	RESPONSE REGULATOR receiver
BUW47_RS03095	COG3716	PTS system mannose fructose sorbose family IID component
BUW47_RS03100	COG3715	PTS system
BUW47_RS03120	COG1307	EDD domain protein, DegV family
BUW47_RS03125	COG1482	cell wall glycoprotein biosynthetic process
BUW47_RS03130	COG0583	DNA-binding transcription factor activity
BUW47_RS03135	COG2855	membrane
BUW47_RS03145	COG0561	phosphatase activity
BUW47_RS03150	COG2755	lipolytic protein G-D-S-L family
BUW47_RS03150	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
BUW47_RS03160	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BUW47_RS03165	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BUW47_RS03180	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BUW47_RS03185	COG2176	DNA-directed DNA polymerase activity
BUW47_RS03195	COG0802	atpase or kinase
BUW47_RS03200	COG0280	phosphate acetyltransferase
BUW47_RS03205	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
BUW47_RS03215	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
BUW47_RS03220	COG0557	exoribonuclease II activity
BUW47_RS03235	COG1113	amino acid transport
BUW47_RS03240	COG0148	phosphopyruvate hydratase activity
BUW47_RS03245	COG0149	triose-phosphate isomerase activity
BUW47_RS03250	COG0126	phosphoglycerate kinase activity
BUW47_RS03270	COG0740	serine-type endopeptidase activity
BUW47_RS03275	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
BUW47_RS03280	COG1481	regulation of sporulation
BUW47_RS03285	COG0391	Required for morphogenesis under gluconeogenic growth conditions
BUW47_RS03290	COG1660	Displays ATPase and GTPase activities
BUW47_RS03300	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BUW47_RS03305	COG0556	nucleotide-excision repair
BUW47_RS03320	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BUW47_RS03325	COG0561	phosphatase activity
BUW47_RS03335	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BUW47_RS03340	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BUW47_RS03345	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
BUW47_RS03350	COG0492	ferredoxin-NADP+ reductase activity
BUW47_RS03370	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BUW47_RS03375	COG0436	Aminotransferase
BUW47_RS03380	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BUW47_RS03390	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
BUW47_RS03395	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BUW47_RS03400	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
BUW47_RS03405	COG1950	PFAM Membrane protein of
BUW47_RS03420	COG0653	protein targeting
BUW47_RS03440	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
BUW47_RS03445	COG1739	Uncharacterized protein family UPF0029
BUW47_RS03460	COG0531	amino acid
BUW47_RS03465	COG0459	protein refolding
BUW47_RS03470	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
BUW47_RS03475	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
BUW47_RS03480	COG0488	(ABC) transporter
BUW47_RS03490	COG1268	BioY protein
BUW47_RS03495	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
BUW47_RS03500	COG0825	malonyl-CoA metabolic process
BUW47_RS03505	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
BUW47_RS03510	COG0439	Biotin carboxylase
BUW47_RS03520	COG0511	ligase activity, forming carbon-carbon bonds
BUW47_RS03525	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BUW47_RS03530	COG1028	Short-chain dehydrogenase reductase Sdr
BUW47_RS03535	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
BUW47_RS03545	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BUW47_RS03550	COG1846	Transcriptional regulator
BUW47_RS03555	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BUW47_RS03565	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BUW47_RS03575	COG1214	PFAM Peptidase M22, glycoprotease
BUW47_RS03580	COG0436	Aminotransferase
BUW47_RS03585	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
BUW47_RS03595	COG2235	arginine
BUW47_RS03605	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
BUW47_RS03615	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BUW47_RS03620	COG0248	Ppx GppA phosphatase
BUW47_RS03625	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
BUW47_RS03645	COG4467	Involved in initiation control of chromosome replication
BUW47_RS03650	COG0470	DNA polymerase III
BUW47_RS03655	COG3870	Protein conserved in bacteria
BUW47_RS03660	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
BUW47_RS03670	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
BUW47_RS03675	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
BUW47_RS03680	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
BUW47_RS03690	COG0590	tRNA wobble adenosine to inosine editing
BUW47_RS03695	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
BUW47_RS03700	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BUW47_RS03705	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BUW47_RS03710	COG1114	Component of the transport system for branched-chain amino acids
BUW47_RS03715	COG1012	belongs to the aldehyde dehydrogenase family
BUW47_RS03715	COG1454	alcohol dehydrogenase
BUW47_RS03720	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
BUW47_RS03725	COG4988	ABC transporter
BUW47_RS03730	COG1294	oxidase, subunit
BUW47_RS03735	COG1271	oxidase subunit
BUW47_RS03740	COG0222	ribosome binding
BUW47_RS03745	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BUW47_RS03750	COG0531	amino acid
BUW47_RS03755	COG0081	regulation of translation
BUW47_RS03760	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BUW47_RS03765	COG0250	Participates in transcription elongation, termination and antitermination
BUW47_RS03775	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BUW47_RS03785	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BUW47_RS03790	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
BUW47_RS03795	COG0215	cysteine-tRNA ligase activity
BUW47_RS03805	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BUW47_RS03810	COG4956	integral membrane protein (PIN domain superfamily)
BUW47_RS03815	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
BUW47_RS03820	COG0756	dUTP diphosphatase activity
BUW47_RS03835	COG0110	maltose O-acetyltransferase activity
BUW47_RS03855	COG3250	beta-galactosidase activity
BUW47_RS03860	COG3250	beta-galactosidase activity
BUW47_RS03870	COG3091	SprT-like family
BUW47_RS03875	COG2183	response to ionizing radiation
BUW47_RS03880	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
BUW47_RS03885	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
BUW47_RS03890	COG2188	Transcriptional regulator
BUW47_RS03895	COG1794	racemase activity, acting on amino acids and derivatives
BUW47_RS03920	COG3104	oligopeptide transport
BUW47_RS03955	COG0477	Major facilitator Superfamily
BUW47_RS04010	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BUW47_RS04015	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BUW47_RS04020	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
BUW47_RS04035	COG0037	tRNA processing
BUW47_RS04040	COG1098	S1 RNA binding domain
BUW47_RS04050	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
BUW47_RS04055	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BUW47_RS04060	COG0193	aminoacyl-tRNA hydrolase activity
BUW47_RS04070	COG2337	Toxic component of a toxin-antitoxin (TA) module
BUW47_RS04075	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BUW47_RS04080	COG0736	holo-[acyl-carrier-protein] synthase activity
BUW47_RS04090	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BUW47_RS04095	COG0501	Belongs to the peptidase M48B family
BUW47_RS04100	COG1704	LemA family
BUW47_RS04105	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BUW47_RS04110	COG3764	Sortase (surface protein transpeptidase)
BUW47_RS04120	COG0254	rRNA binding
BUW47_RS04125	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BUW47_RS04130	COG0504	CTP synthase activity
BUW47_RS04135	COG3343	RNA polymerase activity
BUW47_RS04145	COG1078	dGTPase activity
BUW47_RS04150	COG0561	phosphatase activity
BUW47_RS04160	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BUW47_RS04165	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BUW47_RS04170	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BUW47_RS04175	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BUW47_RS04180	COG1121	(ABC) transporter
BUW47_RS04190	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
BUW47_RS04195	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BUW47_RS04200	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
BUW47_RS04205	COG0084	hydrolase, TatD family'
BUW47_RS04210	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BUW47_RS04210	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BUW47_RS04215	COG1801	Protein of unknown function DUF72
BUW47_RS04225	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BUW47_RS04240	COG0248	Ppx GppA phosphatase
BUW47_RS04245	COG3973	AAA domain
BUW47_RS04255	COG1464	Belongs to the NlpA lipoprotein family
BUW47_RS04265	COG0778	Nitroreductase
BUW47_RS04285	COG1063	alcohol dehydrogenase
BUW47_RS04290	COG0675	Transposase, IS605 OrfB family
BUW47_RS04340	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
BUW47_RS04370	COG0708	Exodeoxyribonuclease III
BUW47_RS04390	COG0477	Major facilitator Superfamily
BUW47_RS04395	COG1120	ATPase activity
BUW47_RS04440	COG0667	Aldo Keto reductase
BUW47_RS04450	COG0656	L-ascorbic acid biosynthetic process
BUW47_RS04470	COG0596	Alpha beta hydrolase
BUW47_RS04485	COG0675	Transposase, IS605 OrfB family
BUW47_RS04545	COG0436	Aminotransferase
BUW47_RS04550	COG0588	phosphoglycerate mutase activity
BUW47_RS04555	COG0151	Belongs to the GarS family
BUW47_RS04560	COG0138	bifunctional purine biosynthesis protein purh
BUW47_RS04565	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
BUW47_RS04570	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
BUW47_RS04580	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BUW47_RS04585	COG0047	phosphoribosylformylglycinamidine synthase activity
BUW47_RS04590	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BUW47_RS04595	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
BUW47_RS04600	COG1472	Belongs to the glycosyl hydrolase 3 family
BUW47_RS04615	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BUW47_RS04620	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
BUW47_RS04625	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
BUW47_RS04630	COG2759	Belongs to the formate--tetrahydrofolate ligase family
BUW47_RS04635	COG0628	permease
BUW47_RS04655	COG0675	Transposase, IS605 OrfB family
BUW47_RS04660	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
BUW47_RS04680	COG1686	Belongs to the peptidase S11 family
BUW47_RS04685	COG5002	protein histidine kinase activity
BUW47_RS04690	COG0745	RESPONSE REGULATOR receiver
BUW47_RS04725	COG5039	Polysaccharide pyruvyl transferase
BUW47_RS04730	COG1215	transferase activity, transferring glycosyl groups
BUW47_RS04740	COG0438	transferase activity, transferring glycosyl groups
BUW47_RS04745	COG0297	glycogen (starch) synthase activity
BUW47_RS04770	COG4464	protein tyrosine phosphatase activity
BUW47_RS04775	COG0489	protein tyrosine kinase activity
BUW47_RS04785	COG1316	TRANSCRIPTIONal
BUW47_RS04790	COG0516	GMP reductase activity
BUW47_RS04790	COG0517	IMP dehydrogenase activity
BUW47_RS04800	COG0012	GTP binding
BUW47_RS04805	COG4481	Protein conserved in bacteria
BUW47_RS04810	COG1475	DNA binding
BUW47_RS04820	COG0357	Ribosomal RNA small subunit methyltransferase G
BUW47_RS04830	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BUW47_RS04835	COG1113	amino acid transport
BUW47_RS04845	COG0765	amino acid transport
BUW47_RS04850	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BUW47_RS04865	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
BUW47_RS04870	COG0419	ATPase involved in DNA repair
BUW47_RS04875	COG0420	3'-5' exonuclease activity
BUW47_RS04885	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BUW47_RS04890	COG1696	Membrane protein involved in D-alanine export
BUW47_RS04900	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
BUW47_RS04910	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BUW47_RS04915	COG0675	Transposase, IS605 OrfB family
BUW47_RS04950	COG0438	transferase activity, transferring glycosyl groups
BUW47_RS04965	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
BUW47_RS04970	COG0284	orotidine-5'-phosphate decarboxylase activity
BUW47_RS04975	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
BUW47_RS04980	COG1012	belongs to the aldehyde dehydrogenase family
BUW47_RS04985	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
BUW47_RS05020	COG0656	L-ascorbic acid biosynthetic process
BUW47_RS05025	COG1074	ATP-dependent DNA helicase activity
BUW47_RS05030	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
BUW47_RS05050	COG0436	Aminotransferase
BUW47_RS05075	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BUW47_RS05090	COG1609	Transcriptional regulator
BUW47_RS05095	COG1959	2 iron, 2 sulfur cluster binding
BUW47_RS05100	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
BUW47_RS05105	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BUW47_RS05110	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
BUW47_RS05130	COG0745	RESPONSE REGULATOR receiver
BUW47_RS05155	COG0305	Participates in initiation and elongation during chromosome replication
BUW47_RS05160	COG0359	binds to the 23S rRNA
BUW47_RS05170	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
BUW47_RS05175	COG0629	single-stranded DNA binding
BUW47_RS05180	COG0360	Binds together with S18 to 16S ribosomal RNA
BUW47_RS05190	COG0187	DNA topoisomerase II activity
BUW47_RS05195	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BUW47_RS05200	COG2501	S4 domain
BUW47_RS05205	COG0592	DNA-directed DNA polymerase activity
BUW47_RS05210	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BUW47_RS05220	COG0230	Belongs to the bacterial ribosomal protein bL34 family
BUW47_RS05225	COG0594	ribonuclease P activity
BUW47_RS05230	COG0706	membrane insertase activity
BUW47_RS05240	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BUW47_RS05245	COG0445	tRNA wobble uridine modification
BUW47_RS05260	COG1970	mechanosensitive ion channel activity
BUW47_RS05265	COG0833	amino acid
BUW47_RS05270	COG0367	asparagine synthase
BUW47_RS05275	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BUW47_RS05290	COG2801	Transposase and inactivated derivatives
BUW47_RS05305	COG0675	Transposase, IS605 OrfB family
BUW47_RS05320	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BUW47_RS05335	COG1063	alcohol dehydrogenase
BUW47_RS05365	COG0640	Transcriptional regulator
BUW47_RS05370	COG1388	LysM domain
BUW47_RS05370	COG1705	Flagellar rod assembly protein muramidase FlgJ
BUW47_RS05390	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BUW47_RS05395	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
BUW47_RS05405	COG2249	NAD(P)H dehydrogenase (quinone) activity
BUW47_RS05415	COG3189	MarR family transcriptional regulator
BUW47_RS05420	COG2094	Belongs to the DNA glycosylase MPG family
BUW47_RS05440	COG2252	PERMEase
BUW47_RS05445	COG3590	peptidase
BUW47_RS05450	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
BUW47_RS05460	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BUW47_RS05465	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BUW47_RS05475	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BUW47_RS05480	COG0765	amino acid transport
BUW47_RS05485	COG1126	abc transporter atp-binding protein
BUW47_RS05500	COG1881	PFAM PEBP family protein
BUW47_RS05505	COG2365	Tyrosine phosphatase family
BUW47_RS05515	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
BUW47_RS05520	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
BUW47_RS05525	COG1609	Transcriptional regulator
BUW47_RS05570	COG0577	efflux transmembrane transporter activity
BUW47_RS05590	COG0277	FAD linked oxidase domain protein
BUW47_RS05610	COG1301	dicarboxylic acid transport
BUW47_RS05615	COG1164	Oligoendopeptidase f
BUW47_RS05620	COG1609	Transcriptional regulator
BUW47_RS05625	COG1028	Short-chain dehydrogenase reductase Sdr
BUW47_RS05630	COG1522	sequence-specific DNA binding
BUW47_RS05635	COG0589	response to stress
BUW47_RS05640	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
BUW47_RS05650	COG2807	transmembrane transport
BUW47_RS05665	COG1253	flavin adenine dinucleotide binding
BUW47_RS05695	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BUW47_RS05700	COG2188	Transcriptional regulator
BUW47_RS05705	COG0561	phosphatase activity
BUW47_RS05725	COG1609	Transcriptional regulator
BUW47_RS05740	COG1070	Carbohydrate kinase
BUW47_RS05745	COG3623	hexulose-6-phosphate isomerase
BUW47_RS05760	COG3775	system Galactitol-specific IIC component
BUW47_RS05770	COG2731	YhcH YjgK YiaL family protein
BUW47_RS05775	COG2814	Major facilitator Superfamily
BUW47_RS05800	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BUW47_RS05805	COG3037	sugar-specific permease SgaT UlaA
BUW47_RS05840	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BUW47_RS05845	COG3875	lactate racemase activity
BUW47_RS05850	COG1691	(AIR) carboxylase
BUW47_RS05855	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
BUW47_RS05860	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BUW47_RS05865	COG1606	tRNA processing
BUW47_RS05870	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
BUW47_RS05890	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
BUW47_RS05895	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BUW47_RS05920	COG0589	response to stress
BUW47_RS05940	COG1396	sequence-specific DNA binding
BUW47_RS05955	COG0095	Lipoate-protein ligase
BUW47_RS05975	COG1122	ATPase activity
BUW47_RS05985	COG1957	nucleoside hydrolase
BUW47_RS05990	COG0492	ferredoxin-NADP+ reductase activity
BUW47_RS05995	COG2217	Heavy metal translocating P-type atpase
BUW47_RS06000	COG2608	mercury ion transmembrane transporter activity
BUW47_RS06010	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BUW47_RS06020	COG1368	sulfuric ester hydrolase activity
BUW47_RS06030	COG0702	epimerase
BUW47_RS06035	COG2233	PERMEase
BUW47_RS06045	COG0564	pseudouridine synthase activity
BUW47_RS06050	COG0861	Integral membrane protein TerC family
BUW47_RS06055	COG3118	belongs to the thioredoxin family
BUW47_RS06080	COG2084	Dehydrogenase
BUW47_RS06085	COG1609	Transcriptional regulator
BUW47_RS06095	COG1940	carbohydrate kinase activity
BUW47_RS06100	COG0534	Mate efflux family protein
BUW47_RS06105	COG0004	ammonium transporteR
BUW47_RS06115	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
BUW47_RS06120	COG4120	Belongs to the binding-protein-dependent transport system permease family
BUW47_RS06130	COG0488	(ABC) transporter
BUW47_RS06140	COG1376	ErfK ybiS ycfS ynhG family protein
BUW47_RS06150	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BUW47_RS06155	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BUW47_RS06160	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BUW47_RS06175	COG2267	carboxylic ester hydrolase activity
BUW47_RS06180	COG2936	dipeptidyl-peptidase activity
BUW47_RS06185	COG0531	amino acid
BUW47_RS06195	COG0194	GDP metabolic process
BUW47_RS06200	COG0735	belongs to the Fur family
BUW47_RS06215	COG2017	converts alpha-aldose to the beta-anomer
BUW47_RS06225	COG1511	domain protein
BUW47_RS06245	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
BUW47_RS06265	COG0531	amino acid
BUW47_RS06275	COG4948	Mandelate Racemase Muconate Lactonizing
BUW47_RS06280	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BUW47_RS06290	COG0586	Pfam SNARE associated Golgi protein
BUW47_RS06295	COG3973	AAA domain
BUW47_RS06305	COG1368	sulfuric ester hydrolase activity
BUW47_RS06310	COG1028	Short-chain dehydrogenase reductase Sdr
BUW47_RS06320	COG1072	(Pantothenic acid kinase))
BUW47_RS06325	COG5002	protein histidine kinase activity
BUW47_RS06330	COG0745	RESPONSE REGULATOR receiver
BUW47_RS06335	COG2357	RelA SpoT domain protein
BUW47_RS06340	COG0519	Catalyzes the synthesis of GMP from XMP
BUW47_RS06350	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BUW47_RS06365	COG0640	Transcriptional regulator
BUW47_RS06370	COG2070	2-Nitropropane dioxygenase
BUW47_RS06380	COG0393	Putative heavy-metal-binding
BUW47_RS06395	COG3328	transposase activity
BUW47_RS06410	COG1136	(ABC) transporter
BUW47_RS06420	COG0745	RESPONSE REGULATOR receiver
BUW47_RS06435	COG1136	(ABC) transporter
BUW47_RS06435	COG0577	efflux transmembrane transporter activity
BUW47_RS06450	COG1136	(ABC) transporter
BUW47_RS06470	COG0165	Argininosuccinate lyase
BUW47_RS06475	COG0110	maltose O-acetyltransferase activity
BUW47_RS06480	COG0494	nUDIX hydrolase
BUW47_RS06490	COG0531	amino acid
BUW47_RS06520	COG3118	belongs to the thioredoxin family
BUW47_RS06535	COG1914	H( )-stimulated, divalent metal cation uptake system
BUW47_RS06540	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
BUW47_RS06545	COG0439	Biotin carboxylase
BUW47_RS06555	COG1984	allophanate hydrolase subunit 2
BUW47_RS06560	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
BUW47_RS06565	COG0789	Transcriptional regulator
BUW47_RS06575	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BUW47_RS06590	COG2502	aspartate--ammonia ligase
BUW47_RS06595	COG1011	Hydrolase
BUW47_RS06600	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
BUW47_RS06605	COG1854	S-ribosylhomocysteine lyase activity
BUW47_RS06630	COG2814	Major facilitator Superfamily
BUW47_RS06640	COG0494	nUDIX hydrolase
BUW47_RS06660	COG2706	6-phosphogluconolactonase activity
BUW47_RS06670	COG1686	Belongs to the peptidase S11 family
BUW47_RS06690	COG2326	polyphosphate kinase activity
BUW47_RS06695	COG0583	DNA-binding transcription factor activity
BUW47_RS06715	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BUW47_RS06715	COG1263	PTS System
BUW47_RS06715	COG2190	(PTS) system
BUW47_RS06745	COG1917	Cupin 2, conserved barrel domain protein
BUW47_RS06745	COG2207	Transcriptional regulator
BUW47_RS06755	COG3507	Belongs to the glycosyl hydrolase 43 family
BUW47_RS06760	COG2814	Major facilitator Superfamily
BUW47_RS06765	COG3250	beta-galactosidase activity
BUW47_RS06770	COG0657	acetylesterase activity
BUW47_RS06785	COG0583	DNA-binding transcription factor activity
BUW47_RS06790	COG0281	malic enzyme
BUW47_RS06795	COG3976	FMN-binding domain protein
BUW47_RS06795	COG1053	succinate dehydrogenase
BUW47_RS06795	COG0431	NADPH-dependent FMN reductase
BUW47_RS06800	COG0431	NADPH-dependent FMN reductase
BUW47_RS06800	COG3976	FMN-binding domain protein
BUW47_RS06800	COG1053	succinate dehydrogenase
BUW47_RS06805	COG0114	fumarate hydratase activity
BUW47_RS06810	COG1053	succinate dehydrogenase
BUW47_RS06815	COG0471	metal ion transport
BUW47_RS06835	COG0657	acetylesterase activity
BUW47_RS06840	COG0693	protein deglycase activity
BUW47_RS06845	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
BUW47_RS06845	COG0392	lysyltransferase activity
BUW47_RS06855	COG0564	pseudouridine synthase activity
BUW47_RS06870	COG1609	Transcriptional regulator
BUW47_RS06880	COG2160	L-arabinose isomerase activity
BUW47_RS06890	COG2814	Major facilitator Superfamily
BUW47_RS06945	COG1278	Cold shock
BUW47_RS06975	COG0833	amino acid
BUW47_RS06980	COG1428	Deoxynucleoside kinase
BUW47_RS07010	COG1028	Short-chain dehydrogenase reductase Sdr
BUW47_RS07015	COG1028	Short-chain dehydrogenase reductase Sdr
BUW47_RS07025	COG1968	undecaprenyl-diphosphatase activity
BUW47_RS07040	COG0789	Transcriptional regulator
BUW47_RS07045	COG1028	Short-chain dehydrogenase reductase Sdr
BUW47_RS07050	COG0110	maltose O-acetyltransferase activity
BUW47_RS07065	COG1064	alcohol dehydrogenase
BUW47_RS07070	COG4463	regulation of RNA biosynthetic process
BUW47_RS07075	COG0542	response to heat
BUW47_RS07085	COG0085	RNA polymerase activity
BUW47_RS07090	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BUW47_RS07095	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
BUW47_RS07105	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
BUW47_RS07110	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BUW47_RS07115	COG0049	tRNA binding
BUW47_RS07120	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BUW47_RS07130	COG0051	transcription antitermination factor activity, RNA binding
BUW47_RS07135	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BUW47_RS07140	COG0088	Forms part of the polypeptide exit tunnel
BUW47_RS07145	COG0089	rRNA binding
BUW47_RS07150	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
BUW47_RS07155	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
BUW47_RS07160	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
BUW47_RS07165	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
BUW47_RS07170	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BUW47_RS07175	COG0255	Belongs to the universal ribosomal protein uL29 family
BUW47_RS07185	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
BUW47_RS07190	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
BUW47_RS07195	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
BUW47_RS07200	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BUW47_RS07205	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
BUW47_RS07210	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
BUW47_RS07215	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
BUW47_RS07220	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
BUW47_RS07225	COG1841	ribosomal large subunit assembly
BUW47_RS07230	COG0200	Binds to the 23S rRNA
BUW47_RS07240	COG0563	adenylate kinase activity
BUW47_RS07245	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
BUW47_RS07250	COG0257	Belongs to the bacterial ribosomal protein bL36 family
BUW47_RS07255	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
BUW47_RS07260	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
BUW47_RS07265	COG0202	RNA polymerase activity
BUW47_RS07270	COG0203	ribosomal protein L17
BUW47_RS07275	COG1122	ATPase activity
BUW47_RS07280	COG1122	ATPase activity
BUW47_RS07290	COG0101	tRNA pseudouridine synthase activity
BUW47_RS07295	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
BUW47_RS07300	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BUW47_RS07315	COG1705	Flagellar rod assembly protein muramidase FlgJ
BUW47_RS07320	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BUW47_RS07335	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BUW47_RS07340	COG4851	CamS sex pheromone cAM373 precursor
BUW47_RS07345	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BUW47_RS07350	COG0154	amidase activity
BUW47_RS07355	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BUW47_RS07360	COG1597	lipid kinase activity
BUW47_RS07365	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BUW47_RS07380	COG2226	methyltransferase
BUW47_RS07430	COG0740	serine-type endopeptidase activity
BUW47_RS07435	COG4695	Portal protein
BUW47_RS07505	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BUW47_RS07505	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BUW47_RS07585	COG3620	sequence-specific DNA binding
BUW47_RS07600	COG2315	Protein conserved in bacteria
BUW47_RS07610	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BUW47_RS07610	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BUW47_RS07615	COG2723	6-phospho-beta-galactosidase activity
BUW47_RS07680	COG2801	Transposase and inactivated derivatives
BUW47_RS07700	COG1757	Na H antiporter
BUW47_RS07710	COG3760	aminoacyl-tRNA metabolism involved in translational fidelity
BUW47_RS07730	COG2226	methyltransferase
BUW47_RS07745	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BUW47_RS07755	COG1846	Transcriptional regulator
BUW47_RS07760	COG1316	TRANSCRIPTIONal
BUW47_RS07770	COG0783	Belongs to the Dps family
BUW47_RS07775	COG0488	(ABC) transporter
BUW47_RS07790	COG4841	protein insertion into membrane
BUW47_RS07800	COG2918	glutathione biosynthetic process
BUW47_RS07825	COG0513	Belongs to the DEAD box helicase family
BUW47_RS07835	COG2246	polysaccharide biosynthetic process
BUW47_RS07840	COG0716	FMN binding
BUW47_RS07845	COG0024	Methionine aminopeptidase
BUW47_RS07855	COG1295	ribonuclease BN
BUW47_RS07870	COG2137	regulation of response to DNA damage stimulus
BUW47_RS07875	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BUW47_RS07900	COG0438	transferase activity, transferring glycosyl groups
BUW47_RS07910	COG0562	UDP-galactopyranose mutase
BUW47_RS07920	COG0438	transferase activity, transferring glycosyl groups
BUW47_RS07930	COG1705	Flagellar rod assembly protein muramidase FlgJ
BUW47_RS07945	COG0791	NLP P60 protein
BUW47_RS07955	COG0463	Glycosyl transferase, family 2
BUW47_RS07960	COG0628	permease
BUW47_RS07970	COG0463	Glycosyl transferase, family 2
BUW47_RS07980	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
BUW47_RS07990	COG1216	Glycosyl transferase, family 2
BUW47_RS08000	COG1088	dTDP-glucose 4,6-dehydratase activity
BUW47_RS08010	COG2801	Transposase and inactivated derivatives
BUW47_RS08015	COG2188	Transcriptional regulator
BUW47_RS08020	COG1131	(ABC) transporter
BUW47_RS08040	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BUW47_RS08055	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
BUW47_RS08060	COG1335	isochorismatase
BUW47_RS08070	COG0542	response to heat
BUW47_RS08085	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BUW47_RS08090	COG0438	transferase activity, transferring glycosyl groups
BUW47_RS08095	COG0438	transferase activity, transferring glycosyl groups
BUW47_RS08185	COG2076	Multidrug Resistance protein
BUW47_RS08190	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BUW47_RS08195	COG0765	amino acid transport
BUW47_RS08205	COG0602	queuosine metabolic process
BUW47_RS08215	COG2233	PERMEase
BUW47_RS08235	COG1607	acyl-coa hydrolase
BUW47_RS08260	COG0675	Transposase, IS605 OrfB family
BUW47_RS08275	COG1113	amino acid transport
BUW47_RS08285	COG2814	Major facilitator Superfamily
BUW47_RS08290	COG2818	Glycosylase
BUW47_RS08300	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BUW47_RS08305	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
BUW47_RS08310	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
BUW47_RS08315	COG0671	phosphoesterase, PA-phosphatase related
BUW47_RS08320	COG0495	leucyl-tRNA aminoacylation
BUW47_RS08330	COG2244	polysaccharide biosynthetic process
BUW47_RS08340	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
BUW47_RS08345	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BUW47_RS08350	COG0589	response to stress
BUW47_RS08360	COG1388	LysM domain
BUW47_RS08360	COG1705	Flagellar rod assembly protein muramidase FlgJ
BUW47_RS08365	COG1428	Deoxynucleoside kinase
BUW47_RS08375	COG1609	Transcriptional regulator
BUW47_RS08390	COG0302	gtp cyclohydrolase
BUW47_RS08390	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BUW47_RS08395	COG0302	gtp cyclohydrolase
BUW47_RS08405	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
BUW47_RS08410	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
BUW47_RS08430	COG0018	arginyl-trna synthetase
BUW47_RS08435	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BUW47_RS08440	COG3679	Belongs to the UPF0342 family
BUW47_RS08445	COG3481	metal-dependent phosphohydrolase, HD sub domain
BUW47_RS08460	COG0537	adenosine 5'-monophosphoramidase activity
BUW47_RS08465	COG1131	(ABC) transporter
BUW47_RS08475	COG0220	tRNA (guanine-N7-)-methyltransferase activity
BUW47_RS08485	COG3118	belongs to the thioredoxin family
BUW47_RS08490	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BUW47_RS08495	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BUW47_RS08500	COG0670	Belongs to the BI1 family
BUW47_RS08515	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BUW47_RS08520	COG0237	dephospho-CoA kinase activity
BUW47_RS08525	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
BUW47_RS08535	COG1484	DNA-dependent DNA replication
BUW47_RS08540	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BUW47_RS08545	COG0291	Belongs to the bacterial ribosomal protein bL35 family
BUW47_RS08550	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
BUW47_RS08570	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
BUW47_RS08580	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BUW47_RS08590	COG0799	negative regulation of ribosome biogenesis
BUW47_RS08595	COG2226	methyltransferase
BUW47_RS08600	COG1323	Belongs to the UPF0348 family
BUW47_RS08610	COG0333	Belongs to the bacterial ribosomal protein bL32 family
BUW47_RS08615	COG0745	RESPONSE REGULATOR receiver
BUW47_RS08620	COG5002	protein histidine kinase activity
BUW47_RS08630	COG0242	peptide deformylase activity
BUW47_RS08635	COG0706	membrane insertase activity
BUW47_RS08640	COG1254	Belongs to the acylphosphatase family
BUW47_RS08645	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BUW47_RS08655	COG1733	regulation of RNA biosynthetic process
BUW47_RS08660	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
BUW47_RS08665	COG0072	phenylalanine-tRNA ligase activity
BUW47_RS08665	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BUW47_RS08670	COG0572	uridine kinase
BUW47_RS08675	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BUW47_RS08685	COG0768	penicillin binding
BUW47_RS08690	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BUW47_RS08695	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BUW47_RS08710	COG1940	carbohydrate kinase activity
BUW47_RS08715	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BUW47_RS08725	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BUW47_RS08755	COG1309	transcriptional regulator
BUW47_RS08760	COG0261	This protein binds to 23S rRNA in the presence of protein L20
BUW47_RS08770	COG0211	Belongs to the bacterial ribosomal protein bL27 family
BUW47_RS08775	COG0006	proline dipeptidase activity
BUW47_RS08780	COG1302	Protein conserved in bacteria
BUW47_RS08785	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BUW47_RS08790	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BUW47_RS08795	COG1570	exodeoxyribonuclease VII activity
BUW47_RS08810	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
BUW47_RS08815	COG1438	arginine binding
BUW47_RS08820	COG0497	DNA recombination
BUW47_RS08835	COG1758	RNA polymerase activity
BUW47_RS08840	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BUW47_RS08845	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BUW47_RS08850	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BUW47_RS08855	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BUW47_RS08855	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BUW47_RS08865	COG0515	serine threonine protein kinase
BUW47_RS08865	COG2815	serine threonine protein kinase
BUW47_RS08870	COG1162	GTPase activity
BUW47_RS08875	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BUW47_RS08880	COG1564	THIamine pyrophosphokinase
BUW47_RS08885	COG0227	Belongs to the bacterial ribosomal protein bL28 family
BUW47_RS08900	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BUW47_RS08905	COG0416	fatty acid biosynthetic process
BUW47_RS08910	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BUW47_RS08915	COG0571	ribonuclease III activity
BUW47_RS08920	COG1196	nuclear chromosome segregation
BUW47_RS08925	COG0552	protein localization to endoplasmic reticulum
BUW47_RS08930	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
BUW47_RS08940	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BUW47_RS08955	COG0745	RESPONSE REGULATOR receiver
BUW47_RS08960	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
BUW47_RS08965	COG0573	inorganic phosphate transmembrane transporter activity
BUW47_RS08970	COG0581	inorganic phosphate transmembrane transporter activity
BUW47_RS08985	COG0228	four-way junction DNA binding
BUW47_RS08990	COG1837	Belongs to the UPF0109 family
BUW47_RS09000	COG0336	Belongs to the RNA methyltransferase TrmD family
BUW47_RS09005	COG0531	amino acid
BUW47_RS09010	COG0335	large ribosomal subunit rRNA binding
BUW47_RS09030	COG1857	crispr-associated protein
BUW47_RS09045	COG1518	maintenance of DNA repeat elements
BUW47_RS09065	COG4336	lyase activity
BUW47_RS09075	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BUW47_RS09080	COG0505	Belongs to the CarA family
BUW47_RS09085	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BUW47_RS09090	COG0167	dihydroorotate dehydrogenase activity
BUW47_RS09095	COG0561	phosphatase activity
BUW47_RS09100	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
BUW47_RS09100	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BUW47_RS09110	COG0675	Transposase, IS605 OrfB family
BUW47_RS09115	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BUW47_RS09140	COG1199	ATP-dependent helicase activity
BUW47_RS09140	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BUW47_RS09165	COG0667	Aldo Keto reductase
BUW47_RS09170	COG0697	spore germination
BUW47_RS09180	COG3331	DNA recombination
BUW47_RS09185	COG4474	Belongs to the UPF0398 family
BUW47_RS09190	COG3599	regulation of cell shape
BUW47_RS09210	COG1051	belongs to the nudix hydrolase family
BUW47_RS09215	COG0116	Belongs to the methyltransferase superfamily
BUW47_RS09225	COG1288	antiporter activity
BUW47_RS09230	COG0154	amidase activity
BUW47_RS09245	COG3328	transposase activity
BUW47_RS09250	COG0765	amino acid transport
BUW47_RS09255	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BUW47_RS09265	COG0328	RNA-DNA hybrid ribonuclease activity
BUW47_RS09280	COG0564	pseudouridine synthase activity
BUW47_RS09285	COG0505	Belongs to the CarA family
BUW47_RS09290	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BUW47_RS09300	COG0583	DNA-binding transcription factor activity
BUW47_RS09305	COG0300	oxidoreductase activity
BUW47_RS09325	COG0798	PFAM Bile acid sodium symporter
BUW47_RS09330	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BUW47_RS09345	COG1293	RNA-binding protein homologous to eukaryotic snRNP
BUW47_RS09350	COG1307	EDD domain protein, DegV family
BUW47_RS09360	COG3022	response to hydroperoxide
BUW47_RS09365	COG1418	mRNA catabolic process
BUW47_RS09370	COG0702	epimerase
BUW47_RS09380	COG0083	homoserine kinase activity
BUW47_RS09385	COG0460	homoserine dehydrogenase
BUW47_RS09395	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
BUW47_RS09400	COG1687	branched-chain amino acid
BUW47_RS09430	COG0095	Lipoate-protein ligase
BUW47_RS09445	COG2814	Major facilitator Superfamily
BUW47_RS09450	COG1253	flavin adenine dinucleotide binding
BUW47_RS09460	COG2814	Major facilitator Superfamily
BUW47_RS09470	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BUW47_RS09490	COG0569	domain protein
BUW47_RS09490	COG0475	glutathione-regulated potassium exporter activity
BUW47_RS09495	COG1942	4-Oxalocrotonate Tautomerase
BUW47_RS09500	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
BUW47_RS09530	COG0477	Major facilitator Superfamily
BUW47_RS09545	COG0561	phosphatase activity
BUW47_RS09555	COG3104	oligopeptide transport
BUW47_RS09560	COG0738	Major facilitator superfamily
BUW47_RS09565	COG1605	Chorismate mutase
BUW47_RS09565	COG0077	Prephenate dehydratase
BUW47_RS09570	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
BUW47_RS09580	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
BUW47_RS09585	COG0287	Prephenate dehydrogenase
BUW47_RS09590	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BUW47_RS09595	COG0436	Aminotransferase
BUW47_RS09600	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BUW47_RS09635	COG0719	Fe-S assembly protein
BUW47_RS09640	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BUW47_RS09645	COG0822	iron-sulfur transferase activity
BUW47_RS09650	COG0719	Fe-S assembly protein
BUW47_RS09675	COG2151	metal-sulfur cluster biosynthetic enzyme
BUW47_RS09680	COG1252	NADH dehydrogenase
BUW47_RS09685	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
BUW47_RS09690	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BUW47_RS09710	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BUW47_RS09715	COG2223	nitrite transmembrane transporter activity
BUW47_RS09720	COG2151	metal-sulfur cluster biosynthetic enzyme
BUW47_RS09730	COG2226	methyltransferase
BUW47_RS09755	COG2197	response regulator
BUW47_RS09780	COG0315	cyclic pyranopterin monophosphate synthase activity
BUW47_RS09795	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BUW47_RS09800	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
BUW47_RS09805	COG1140	nitrate reductase beta subunit
BUW47_RS09815	COG2181	nitrate reductase activity
BUW47_RS09850	COG0436	Aminotransferase
BUW47_RS09860	COG1609	Transcriptional regulator
BUW47_RS09865	COG2610	gluconate transmembrane transporter activity
BUW47_RS09895	COG3682	Transcriptional regulator
BUW47_RS09935	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BUW47_RS09955	COG0366	Alpha amylase catalytic
BUW47_RS09960	COG2188	Transcriptional regulator
BUW47_RS09965	COG2190	(PTS) system
BUW47_RS09965	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BUW47_RS09965	COG1263	PTS System
BUW47_RS10000	COG0028	Belongs to the TPP enzyme family
BUW47_RS10005	COG4619	ABC transporter
BUW47_RS10025	COG0584	glycerophosphoryl diester phosphodiesterase
BUW47_RS10030	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BUW47_RS10035	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BUW47_RS10040	COG0402	S-adenosylhomocysteine deaminase activity
BUW47_RS10055	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BUW47_RS10060	COG2918	glutathione biosynthetic process
BUW47_RS10060	COG1181	Belongs to the D-alanine--D-alanine ligase family
BUW47_RS10065	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BUW47_RS10085	COG3479	Phenolic acid decarboxylase
BUW47_RS10090	COG1695	Transcriptional regulator
BUW47_RS10095	COG0105	UTP biosynthetic process
BUW47_RS10110	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BUW47_RS10120	COG1113	amino acid transport
BUW47_RS10140	COG1250	3-hydroxyacyl-CoA dehydrogenase
BUW47_RS10160	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BUW47_RS10165	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
BUW47_RS10170	COG0730	response to heat
BUW47_RS10175	COG0628	permease
BUW47_RS10180	COG0183	Belongs to the thiolase family
BUW47_RS10190	COG0583	DNA-binding transcription factor activity
BUW47_RS10195	COG3976	FMN-binding domain protein
BUW47_RS10195	COG1053	succinate dehydrogenase
BUW47_RS10205	COG0697	spore germination
BUW47_RS10240	COG2848	UPF0210 protein
BUW47_RS10250	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BUW47_RS10255	COG0626	cystathionine gamma-synthase activity
BUW47_RS10265	COG2271	Major facilitator Superfamily
BUW47_RS10270	COG0318	PFAM AMP-dependent synthetase and ligase
BUW47_RS10295	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
BUW47_RS10315	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
BUW47_RS10325	COG1119	ATPase activity
BUW47_RS10360	COG0129	dihydroxy-acid dehydratase activity
BUW47_RS10365	COG2151	metal-sulfur cluster biosynthetic enzyme
BUW47_RS10370	COG0385	Bile acid
BUW47_RS10375	COG2814	Major facilitator Superfamily
BUW47_RS10385	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
BUW47_RS10390	COG0066	3-isopropylmalate dehydratase activity
BUW47_RS10475	COG1732	Glycine betaine
BUW47_RS10500	COG1063	alcohol dehydrogenase
BUW47_RS10520	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
BUW47_RS10525	COG4974	Belongs to the 'phage' integrase family
BUW47_RS10535	COG0538	isocitrate dehydrogenase activity
BUW47_RS10545	COG4720	Psort location CytoplasmicMembrane, score
BUW47_RS10600	COG0477	Major facilitator Superfamily
BUW47_RS10605	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BUW47_RS10620	COG0110	maltose O-acetyltransferase activity
BUW47_RS10625	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BUW47_RS10665	COG2814	Major facilitator Superfamily
BUW47_RS10675	COG2223	nitrite transmembrane transporter activity
BUW47_RS10680	COG1811	Na channel or pump
BUW47_RS10685	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BUW47_RS10700	COG0402	S-adenosylhomocysteine deaminase activity
BUW47_RS10710	COG1956	GAF domain-containing protein
BUW47_RS10720	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BUW47_RS10740	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BUW47_RS10745	COG0187	DNA topoisomerase II activity
BUW47_RS10750	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
BUW47_RS10765	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BUW47_RS10770	COG0758	DNA mediated transformation
BUW47_RS10775	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BUW47_RS10785	COG4479	Belongs to the UPF0346 family
BUW47_RS10790	COG4698	Protein conserved in bacteria
BUW47_RS10795	COG2755	lipolytic protein G-D-S-L family
BUW47_RS10805	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BUW47_RS10810	COG1307	EDD domain protein, DegV family
BUW47_RS10815	COG1272	protein, Hemolysin III
BUW47_RS10820	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
BUW47_RS10825	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
BUW47_RS10830	COG0488	(ABC) transporter
BUW47_RS10835	COG0617	tRNA 3'-terminal CCA addition
BUW47_RS10845	COG0457	Tetratricopeptide repeat
BUW47_RS10855	COG1160	GTP binding
BUW47_RS10860	COG0539	negative regulation of cytoplasmic translation
BUW47_RS10865	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
BUW47_RS10875	COG0514	ATP-dependent DNA helicase (RecQ)
BUW47_RS10885	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
BUW47_RS10890	COG1187	pseudouridine synthase activity
BUW47_RS10895	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
BUW47_RS10900	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
BUW47_RS10925	COG0587	DNA-directed DNA polymerase activity
BUW47_RS10935	COG2195	Cleaves the N-terminal amino acid of tripeptides
BUW47_RS10940	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
BUW47_RS10945	COG2384	SAM-dependent methyltransferase
BUW47_RS10950	COG0569	domain protein
BUW47_RS10955	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BUW47_RS10960	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BUW47_RS10965	COG0436	Aminotransferase
BUW47_RS10970	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
BUW47_RS10975	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BUW47_RS10980	COG1473	amidohydrolase
BUW47_RS10985	COG2171	N-acyltransferase activity
BUW47_RS10990	COG0019	diaminopimelate decarboxylase activity
BUW47_RS10995	COG0527	aspartate kinase activity
BUW47_RS11000	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
BUW47_RS11140	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BUW47_RS11160	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BUW47_RS11160	COG0551	DNA topoisomerase type I activity
BUW47_RS11240	COG0745	RESPONSE REGULATOR receiver
BUW47_RS11255	COG3328	transposase activity
BUW47_RS11325	COG1733	regulation of RNA biosynthetic process
BUW47_RS11335	COG1914	H( )-stimulated, divalent metal cation uptake system
BUW47_RS11345	COG2801	Transposase and inactivated derivatives
BUW47_RS11355	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
BUW47_RS11360	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BUW47_RS11445	COG1674	ftsk spoiiie
BUW47_RS11470	COG4842	Belongs to the WXG100 family
BUW47_RS11490	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BUW47_RS11550	COG2814	Major facilitator Superfamily
BUW47_RS11560	COG0745	RESPONSE REGULATOR receiver
BUW47_RS11575	COG2801	Transposase and inactivated derivatives
BUW47_RS11600	COG2801	Transposase and inactivated derivatives
BUW47_RS11650	COG4221	oxidoreductase activity
BUW47_RS11800	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BUW47_RS11840	COG2223	nitrite transmembrane transporter activity
BUW47_RS11965	COG0657	acetylesterase activity
BUW47_RS11970	COG0588	phosphoglycerate mutase activity
BUW47_RS12005	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)