locus-tag	class	description
ikematsu_RS00005	COG1674	ftsk spoiiie
ikematsu_RS00015	COG0500	methyltransferase
ikematsu_RS00020	COG2706	6-phosphogluconolactonase activity
ikematsu_RS00025	COG0564	pseudouridine synthase activity
ikematsu_RS00030	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ikematsu_RS00035	COG2357	RelA SpoT domain protein
ikematsu_RS00050	COG4862	establishment of competence for transformation
ikematsu_RS00055	COG1393	Belongs to the ArsC family
ikematsu_RS00175	COG0586	Pfam SNARE associated Golgi protein
ikematsu_RS00185	COG0647	UMP catabolic process
ikematsu_RS00190	COG4470	Protein conserved in bacteria
ikematsu_RS00200	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ikematsu_RS00205	COG0827	DNA restriction-modification system
ikematsu_RS00225	COG4537	Required for transformation and DNA binding
ikematsu_RS00235	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ikematsu_RS00245	COG0791	NLP P60 protein
ikematsu_RS00245	COG1388	LysM domain
ikematsu_RS00255	COG0217	transcriptional regulatory protein
ikematsu_RS00265	COG1609	Transcriptional regulator
ikematsu_RS00270	COG0006	proline dipeptidase activity
ikematsu_RS00285	COG0668	transmembrane transport
ikematsu_RS00290	COG0561	phosphatase activity
ikematsu_RS00295	COG0622	Phosphoesterase
ikematsu_RS00300	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ikematsu_RS00305	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
ikematsu_RS00320	COG3118	belongs to the thioredoxin family
ikematsu_RS00325	COG1193	negative regulation of DNA recombination
ikematsu_RS00335	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ikematsu_RS00340	COG3906	Belongs to the UPF0473 family
ikematsu_RS00345	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ikematsu_RS00350	COG4472	Bacterial protein of unknown function (DUF965)
ikematsu_RS00355	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ikematsu_RS00360	COG0513	Belongs to the DEAD box helicase family
ikematsu_RS00365	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
ikematsu_RS00380	COG2255	four-way junction helicase activity
ikematsu_RS00385	COG0632	four-way junction helicase activity
ikematsu_RS00390	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
ikematsu_RS00395	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ikematsu_RS00405	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ikematsu_RS00410	COG1058	Belongs to the CinA family
ikematsu_RS00410	COG1546	Belongs to the CinA family
ikematsu_RS00415	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ikematsu_RS00420	COG1426	Protein conserved in bacteria
ikematsu_RS00425	COG0612	Peptidase, M16
ikematsu_RS00430	COG0612	Peptidase, M16
ikematsu_RS00435	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ikematsu_RS00440	COG1126	abc transporter atp-binding protein
ikematsu_RS00445	COG0765	amino acid transport
ikematsu_RS00455	COG1792	Involved in formation and maintenance of cell shape
ikematsu_RS00460	COG1077	Cell shape determining protein MreB Mrl
ikematsu_RS00470	COG0285	dihydrofolate synthase activity
ikematsu_RS00475	COG0525	valine-tRNA ligase activity
ikematsu_RS00480	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
ikematsu_RS00500	COG1929	Belongs to the glycerate kinase type-1 family
ikematsu_RS00505	COG2610	gluconate transmembrane transporter activity
ikematsu_RS00510	COG0301	tRNA thio-modification
ikematsu_RS00515	COG1104	cysteine desulfurase activity
ikematsu_RS00520	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
ikematsu_RS00525	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ikematsu_RS00540	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ikematsu_RS00560	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ikematsu_RS00580	COG1181	Belongs to the D-alanine--D-alanine ligase family
ikematsu_RS00595	COG0772	Belongs to the SEDS family
ikematsu_RS00605	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
ikematsu_RS00610	COG1077	Cell shape determining protein MreB Mrl
ikematsu_RS00615	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ikematsu_RS00625	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ikematsu_RS00630	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
ikematsu_RS00635	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ikematsu_RS00640	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ikematsu_RS00645	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ikematsu_RS00650	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ikematsu_RS00655	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ikematsu_RS00660	COG0356	it plays a direct role in the translocation of protons across the membrane
ikematsu_RS00665	COG2233	PERMEase
ikematsu_RS00680	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
ikematsu_RS00685	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ikematsu_RS00690	COG0009	L-threonylcarbamoyladenylate synthase
ikematsu_RS00695	COG2890	protein-(glutamine-N5) methyltransferase activity
ikematsu_RS00700	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ikematsu_RS00705	COG1435	thymidine kinase activity
ikematsu_RS00710	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ikematsu_RS00715	COG3442	glutamine amidotransferase
ikematsu_RS00730	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ikematsu_RS00735	COG1132	(ABC) transporter
ikematsu_RS00750	COG3328	transposase activity
ikematsu_RS00775	COG3527	Alpha-acetolactate decarboxylase
ikematsu_RS00780	COG0149	triose-phosphate isomerase activity
ikematsu_RS00785	COG0656	L-ascorbic acid biosynthetic process
ikematsu_RS00815	COG0450	alkyl hydroperoxide reductase
ikematsu_RS00850	COG2115	Belongs to the xylose isomerase family
ikematsu_RS00865	COG4975	Glucose uptake
ikematsu_RS00870	COG5002	protein histidine kinase activity
ikematsu_RS00870	COG3850	Histidine kinase
ikematsu_RS00875	COG0745	RESPONSE REGULATOR receiver
ikematsu_RS00890	COG3716	PTS system mannose fructose sorbose family IID component
ikematsu_RS00895	COG3715	PTS system
ikematsu_RS00915	COG1307	EDD domain protein, DegV family
ikematsu_RS00920	COG1482	cell wall glycoprotein biosynthetic process
ikematsu_RS00930	COG2855	membrane
ikematsu_RS00935	COG3942	CHAP domain
ikematsu_RS00935	COG1388	LysM domain
ikematsu_RS00940	COG0561	phosphatase activity
ikematsu_RS00945	COG2755	lipolytic protein G-D-S-L family
ikematsu_RS00945	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
ikematsu_RS00955	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ikematsu_RS00960	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ikematsu_RS00975	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ikematsu_RS00980	COG2176	DNA-directed DNA polymerase activity
ikematsu_RS00990	COG0802	atpase or kinase
ikematsu_RS00995	COG0280	phosphate acetyltransferase
ikematsu_RS01000	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
ikematsu_RS01010	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ikematsu_RS01015	COG0557	exoribonuclease II activity
ikematsu_RS01030	COG1113	amino acid transport
ikematsu_RS01035	COG0148	phosphopyruvate hydratase activity
ikematsu_RS01040	COG0149	triose-phosphate isomerase activity
ikematsu_RS01045	COG0126	phosphoglycerate kinase activity
ikematsu_RS01055	COG2826	transposase and inactivated derivatives, IS30 family
ikematsu_RS01070	COG0740	serine-type endopeptidase activity
ikematsu_RS01090	COG1481	regulation of sporulation
ikematsu_RS01095	COG0391	Required for morphogenesis under gluconeogenic growth conditions
ikematsu_RS01100	COG1660	Displays ATPase and GTPase activities
ikematsu_RS01110	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ikematsu_RS01115	COG0556	nucleotide-excision repair
ikematsu_RS01130	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ikematsu_RS01135	COG0561	phosphatase activity
ikematsu_RS01145	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ikematsu_RS01150	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ikematsu_RS01155	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
ikematsu_RS01160	COG0492	ferredoxin-NADP+ reductase activity
ikematsu_RS01170	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ikematsu_RS01175	COG0436	Aminotransferase
ikematsu_RS01180	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ikematsu_RS01190	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ikematsu_RS01195	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
ikematsu_RS01200	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
ikematsu_RS01205	COG1950	PFAM Membrane protein of
ikematsu_RS01220	COG0653	protein targeting
ikematsu_RS01235	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
ikematsu_RS01240	COG1739	Uncharacterized protein family UPF0029
ikematsu_RS01250	COG0531	amino acid
ikematsu_RS01255	COG0459	protein refolding
ikematsu_RS01260	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
ikematsu_RS01265	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
ikematsu_RS01270	COG0488	(ABC) transporter
ikematsu_RS01280	COG1268	BioY protein
ikematsu_RS01285	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
ikematsu_RS01290	COG0825	malonyl-CoA metabolic process
ikematsu_RS01295	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
ikematsu_RS01300	COG0439	Biotin carboxylase
ikematsu_RS01310	COG0511	ligase activity, forming carbon-carbon bonds
ikematsu_RS01315	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ikematsu_RS01320	COG1028	Short-chain dehydrogenase reductase Sdr
ikematsu_RS01325	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ikematsu_RS01335	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ikematsu_RS01340	COG1846	Transcriptional regulator
ikematsu_RS01345	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ikematsu_RS01355	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ikematsu_RS01365	COG1214	PFAM Peptidase M22, glycoprotease
ikematsu_RS01370	COG0436	Aminotransferase
ikematsu_RS01375	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ikematsu_RS01385	COG2235	arginine
ikematsu_RS01405	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ikematsu_RS01410	COG0248	Ppx GppA phosphatase
ikematsu_RS01415	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
ikematsu_RS01435	COG4467	Involved in initiation control of chromosome replication
ikematsu_RS01440	COG0470	DNA polymerase III
ikematsu_RS01445	COG3870	Protein conserved in bacteria
ikematsu_RS01450	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ikematsu_RS01460	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
ikematsu_RS01465	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
ikematsu_RS01470	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
ikematsu_RS01480	COG0590	tRNA wobble adenosine to inosine editing
ikematsu_RS01485	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ikematsu_RS01490	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ikematsu_RS01495	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ikematsu_RS01500	COG1114	Component of the transport system for branched-chain amino acids
ikematsu_RS01505	COG1454	alcohol dehydrogenase
ikematsu_RS01505	COG1012	belongs to the aldehyde dehydrogenase family
ikematsu_RS01510	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
ikematsu_RS01515	COG4988	ABC transporter
ikematsu_RS01525	COG1271	oxidase subunit
ikematsu_RS01530	COG0222	ribosome binding
ikematsu_RS01535	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ikematsu_RS01540	COG0531	amino acid
ikematsu_RS01545	COG0081	regulation of translation
ikematsu_RS01550	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
ikematsu_RS01555	COG0250	Participates in transcription elongation, termination and antitermination
ikematsu_RS01565	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ikematsu_RS01575	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ikematsu_RS01580	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
ikematsu_RS01585	COG0215	cysteine-tRNA ligase activity
ikematsu_RS01595	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ikematsu_RS01600	COG4956	integral membrane protein (PIN domain superfamily)
ikematsu_RS01605	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
ikematsu_RS01610	COG0756	dUTP diphosphatase activity
ikematsu_RS01625	COG0110	maltose O-acetyltransferase activity
ikematsu_RS01635	COG0657	acetylesterase activity
ikematsu_RS01640	COG0588	phosphoglycerate mutase activity
ikematsu_RS01650	COG3250	beta-galactosidase activity
ikematsu_RS01655	COG3250	beta-galactosidase activity
ikematsu_RS01665	COG3091	SprT-like family
ikematsu_RS01670	COG2183	response to ionizing radiation
ikematsu_RS01675	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ikematsu_RS01680	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
ikematsu_RS01685	COG2188	Transcriptional regulator
ikematsu_RS01690	COG1794	racemase activity, acting on amino acids and derivatives
ikematsu_RS01715	COG3104	oligopeptide transport
ikematsu_RS01775	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
ikematsu_RS01780	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ikematsu_RS01785	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
ikematsu_RS01800	COG0037	tRNA processing
ikematsu_RS01805	COG1098	S1 RNA binding domain
ikematsu_RS01815	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
ikematsu_RS01820	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ikematsu_RS01825	COG0193	aminoacyl-tRNA hydrolase activity
ikematsu_RS01835	COG2337	Toxic component of a toxin-antitoxin (TA) module
ikematsu_RS01840	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ikematsu_RS01845	COG0736	holo-[acyl-carrier-protein] synthase activity
ikematsu_RS01855	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ikematsu_RS01860	COG0501	Belongs to the peptidase M48B family
ikematsu_RS01865	COG1704	LemA family
ikematsu_RS01870	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ikematsu_RS01875	COG3764	Sortase (surface protein transpeptidase)
ikematsu_RS01880	COG0675	Transposase, IS605 OrfB family
ikematsu_RS01895	COG0254	rRNA binding
ikematsu_RS01900	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ikematsu_RS01905	COG0504	CTP synthase activity
ikematsu_RS01910	COG3343	RNA polymerase activity
ikematsu_RS01920	COG1078	dGTPase activity
ikematsu_RS01925	COG0561	phosphatase activity
ikematsu_RS01935	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ikematsu_RS01940	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ikematsu_RS01945	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ikematsu_RS01950	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ikematsu_RS01965	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
ikematsu_RS01970	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ikematsu_RS01975	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
ikematsu_RS01980	COG0084	hydrolase, TatD family'
ikematsu_RS01985	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ikematsu_RS01985	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ikematsu_RS01990	COG1801	Protein of unknown function DUF72
ikematsu_RS02010	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
ikematsu_RS02025	COG0248	Ppx GppA phosphatase
ikematsu_RS02030	COG3973	AAA domain
ikematsu_RS02040	COG1464	Belongs to the NlpA lipoprotein family
ikematsu_RS02050	COG0778	Nitroreductase
ikematsu_RS02070	COG1063	alcohol dehydrogenase
ikematsu_RS02075	COG0675	Transposase, IS605 OrfB family
ikematsu_RS02120	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
ikematsu_RS02130	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
ikematsu_RS02155	COG0708	Exodeoxyribonuclease III
ikematsu_RS02170	COG0477	Major facilitator Superfamily
ikematsu_RS02175	COG1120	ATPase activity
ikematsu_RS02225	COG0667	Aldo Keto reductase
ikematsu_RS02230	COG0667	Aldo Keto reductase
ikematsu_RS02240	COG0656	L-ascorbic acid biosynthetic process
ikematsu_RS02245	COG4221	oxidoreductase activity
ikematsu_RS02260	COG1942	4-Oxalocrotonate Tautomerase
ikematsu_RS02300	COG0477	Major facilitator Superfamily
ikematsu_RS02325	COG0436	Aminotransferase
ikematsu_RS02330	COG0588	phosphoglycerate mutase activity
ikematsu_RS02335	COG0151	Belongs to the GarS family
ikematsu_RS02340	COG0138	bifunctional purine biosynthesis protein purh
ikematsu_RS02345	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ikematsu_RS02350	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
ikematsu_RS02360	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ikematsu_RS02365	COG0047	phosphoribosylformylglycinamidine synthase activity
ikematsu_RS02370	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ikematsu_RS02375	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
ikematsu_RS02390	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ikematsu_RS02395	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
ikematsu_RS02400	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ikematsu_RS02405	COG2759	Belongs to the formate--tetrahydrofolate ligase family
ikematsu_RS02410	COG0628	permease
ikematsu_RS02420	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ikematsu_RS02440	COG1686	Belongs to the peptidase S11 family
ikematsu_RS02445	COG5002	protein histidine kinase activity
ikematsu_RS02450	COG0745	RESPONSE REGULATOR receiver
ikematsu_RS02460	COG3328	transposase activity
ikematsu_RS02465	COG0517	IMP dehydrogenase activity
ikematsu_RS02465	COG0516	GMP reductase activity
ikematsu_RS02475	COG0012	GTP binding
ikematsu_RS02480	COG4481	Protein conserved in bacteria
ikematsu_RS02485	COG1475	DNA binding
ikematsu_RS02495	COG0357	Ribosomal RNA small subunit methyltransferase G
ikematsu_RS02505	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ikematsu_RS02510	COG1113	amino acid transport
ikematsu_RS02520	COG0765	amino acid transport
ikematsu_RS02525	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ikematsu_RS02540	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
ikematsu_RS02545	COG0419	ATPase involved in DNA repair
ikematsu_RS02550	COG0420	3'-5' exonuclease activity
ikematsu_RS02560	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ikematsu_RS02565	COG1696	Membrane protein involved in D-alanine export
ikematsu_RS02575	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
ikematsu_RS02580	COG0667	Aldo Keto reductase
ikematsu_RS02585	COG1114	Component of the transport system for branched-chain amino acids
ikematsu_RS02590	COG3328	transposase activity
ikematsu_RS02595	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ikematsu_RS02625	COG0438	transferase activity, transferring glycosyl groups
ikematsu_RS02645	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ikematsu_RS02650	COG0284	orotidine-5'-phosphate decarboxylase activity
ikematsu_RS02655	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
ikematsu_RS02660	COG1012	belongs to the aldehyde dehydrogenase family
ikematsu_RS02665	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ikematsu_RS02705	COG0656	L-ascorbic acid biosynthetic process
ikematsu_RS02710	COG1074	ATP-dependent DNA helicase activity
ikematsu_RS02715	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
ikematsu_RS02735	COG0436	Aminotransferase
ikematsu_RS02760	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ikematsu_RS02775	COG1609	Transcriptional regulator
ikematsu_RS02780	COG1959	2 iron, 2 sulfur cluster binding
ikematsu_RS02785	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
ikematsu_RS02795	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
ikematsu_RS02815	COG0745	RESPONSE REGULATOR receiver
ikematsu_RS02840	COG0305	Participates in initiation and elongation during chromosome replication
ikematsu_RS02845	COG0359	binds to the 23S rRNA
ikematsu_RS02855	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ikematsu_RS02860	COG0629	single-stranded DNA binding
ikematsu_RS02865	COG0360	Binds together with S18 to 16S ribosomal RNA
ikematsu_RS02875	COG0187	DNA topoisomerase II activity
ikematsu_RS02880	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ikematsu_RS02885	COG2501	S4 domain
ikematsu_RS02890	COG0592	DNA-directed DNA polymerase activity
ikematsu_RS02895	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ikematsu_RS02905	COG0230	Belongs to the bacterial ribosomal protein bL34 family
ikematsu_RS02910	COG0594	ribonuclease P activity
ikematsu_RS02915	COG0706	membrane insertase activity
ikematsu_RS02925	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
ikematsu_RS02930	COG0445	tRNA wobble uridine modification
ikematsu_RS02955	COG1970	mechanosensitive ion channel activity
ikematsu_RS02960	COG0833	amino acid
ikematsu_RS02965	COG0367	asparagine synthase
ikematsu_RS02970	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ikematsu_RS02995	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ikematsu_RS03010	COG1063	alcohol dehydrogenase
ikematsu_RS03035	COG0640	Transcriptional regulator
ikematsu_RS03040	COG1388	LysM domain
ikematsu_RS03040	COG1705	Flagellar rod assembly protein muramidase FlgJ
ikematsu_RS03045	COG1609	Transcriptional regulator
ikematsu_RS03060	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ikematsu_RS03065	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
ikematsu_RS03075	COG2249	NAD(P)H dehydrogenase (quinone) activity
ikematsu_RS03085	COG3189	MarR family transcriptional regulator
ikematsu_RS03090	COG2094	Belongs to the DNA glycosylase MPG family
ikematsu_RS03110	COG2252	PERMEase
ikematsu_RS03115	COG3590	peptidase
ikematsu_RS03120	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
ikematsu_RS03130	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ikematsu_RS03135	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ikematsu_RS03145	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ikematsu_RS03150	COG0765	amino acid transport
ikematsu_RS03155	COG1126	abc transporter atp-binding protein
ikematsu_RS03165	COG1881	PFAM PEBP family protein
ikematsu_RS03170	COG2365	Tyrosine phosphatase family
ikematsu_RS03180	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
ikematsu_RS03185	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
ikematsu_RS03190	COG1609	Transcriptional regulator
ikematsu_RS03200	COG2211	Major facilitator Superfamily
ikematsu_RS03200	COG2190	(PTS) system
ikematsu_RS03220	COG0577	efflux transmembrane transporter activity
ikematsu_RS03260	COG0477	Major facilitator Superfamily
ikematsu_RS03270	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ikematsu_RS03270	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ikematsu_RS03280	COG0277	FAD linked oxidase domain protein
ikematsu_RS03300	COG1301	dicarboxylic acid transport
ikematsu_RS03305	COG1164	Oligoendopeptidase f
ikematsu_RS03310	COG1609	Transcriptional regulator
ikematsu_RS03315	COG1028	Short-chain dehydrogenase reductase Sdr
ikematsu_RS03320	COG1522	sequence-specific DNA binding
ikematsu_RS03325	COG0589	response to stress
ikematsu_RS03330	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
ikematsu_RS03340	COG2807	transmembrane transport
ikematsu_RS03355	COG1253	flavin adenine dinucleotide binding
ikematsu_RS03385	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ikematsu_RS03390	COG2188	Transcriptional regulator
ikematsu_RS03395	COG0561	phosphatase activity
ikematsu_RS03415	COG1609	Transcriptional regulator
ikematsu_RS03420	COG3775	system Galactitol-specific IIC component
ikematsu_RS03425	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ikematsu_RS03435	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
ikematsu_RS03440	COG2390	Transcriptional regulator
ikematsu_RS03450	COG1869	D-ribose catabolic process
ikematsu_RS03475	COG2826	transposase and inactivated derivatives, IS30 family
ikematsu_RS03480	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ikematsu_RS03485	COG3875	lactate racemase activity
ikematsu_RS03490	COG1691	(AIR) carboxylase
ikematsu_RS03495	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
ikematsu_RS03500	COG1606	tRNA processing
ikematsu_RS03505	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ikematsu_RS03510	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
ikematsu_RS03525	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
ikematsu_RS03530	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ikematsu_RS03555	COG0589	response to stress
ikematsu_RS03575	COG1396	sequence-specific DNA binding
ikematsu_RS03590	COG0095	Lipoate-protein ligase
ikematsu_RS03610	COG1122	ATPase activity
ikematsu_RS03620	COG1957	nucleoside hydrolase
ikematsu_RS03625	COG0492	ferredoxin-NADP+ reductase activity
ikematsu_RS03630	COG2217	Heavy metal translocating P-type atpase
ikematsu_RS03635	COG2608	mercury ion transmembrane transporter activity
ikematsu_RS03645	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ikematsu_RS03655	COG1368	sulfuric ester hydrolase activity
ikematsu_RS03660	COG0406	alpha-ribazole phosphatase activity
ikematsu_RS03665	COG0702	epimerase
ikematsu_RS03670	COG2233	PERMEase
ikematsu_RS03680	COG0564	pseudouridine synthase activity
ikematsu_RS03685	COG0861	Integral membrane protein TerC family
ikematsu_RS03690	COG3118	belongs to the thioredoxin family
ikematsu_RS03710	COG2084	Dehydrogenase
ikematsu_RS03715	COG1609	Transcriptional regulator
ikematsu_RS03725	COG1940	carbohydrate kinase activity
ikematsu_RS03730	COG0534	Mate efflux family protein
ikematsu_RS03735	COG0004	ammonium transporteR
ikematsu_RS03745	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
ikematsu_RS03750	COG4120	Belongs to the binding-protein-dependent transport system permease family
ikematsu_RS03760	COG0488	(ABC) transporter
ikematsu_RS03775	COG1376	ErfK ybiS ycfS ynhG family protein
ikematsu_RS03785	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ikematsu_RS03790	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ikematsu_RS03795	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ikematsu_RS03810	COG2267	carboxylic ester hydrolase activity
ikematsu_RS03815	COG2936	dipeptidyl-peptidase activity
ikematsu_RS03820	COG0531	amino acid
ikematsu_RS03830	COG0194	GDP metabolic process
ikematsu_RS03835	COG0735	belongs to the Fur family
ikematsu_RS03850	COG2017	converts alpha-aldose to the beta-anomer
ikematsu_RS03875	COG3328	transposase activity
ikematsu_RS03900	COG0531	amino acid
ikematsu_RS03910	COG4948	Mandelate Racemase Muconate Lactonizing
ikematsu_RS03925	COG0586	Pfam SNARE associated Golgi protein
ikematsu_RS03930	COG3973	AAA domain
ikematsu_RS03940	COG1368	sulfuric ester hydrolase activity
ikematsu_RS03950	COG1072	(Pantothenic acid kinase))
ikematsu_RS03955	COG5002	protein histidine kinase activity
ikematsu_RS03960	COG0745	RESPONSE REGULATOR receiver
ikematsu_RS03965	COG2357	RelA SpoT domain protein
ikematsu_RS03970	COG0519	Catalyzes the synthesis of GMP from XMP
ikematsu_RS03980	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
ikematsu_RS04010	COG0640	Transcriptional regulator
ikematsu_RS04015	COG2070	2-Nitropropane dioxygenase
ikematsu_RS04025	COG0393	Putative heavy-metal-binding
ikematsu_RS04040	COG1136	(ABC) transporter
ikematsu_RS04040	COG0577	efflux transmembrane transporter activity
ikematsu_RS04075	COG0165	Argininosuccinate lyase
ikematsu_RS04085	COG0494	nUDIX hydrolase
ikematsu_RS04095	COG0531	amino acid
ikematsu_RS04115	COG3118	belongs to the thioredoxin family
ikematsu_RS04130	COG1914	H( )-stimulated, divalent metal cation uptake system
ikematsu_RS04135	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
ikematsu_RS04140	COG0439	Biotin carboxylase
ikematsu_RS04155	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
ikematsu_RS04160	COG0789	Transcriptional regulator
ikematsu_RS04170	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ikematsu_RS04185	COG2502	aspartate--ammonia ligase
ikematsu_RS04190	COG1011	Hydrolase
ikematsu_RS04195	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ikematsu_RS04200	COG1854	S-ribosylhomocysteine lyase activity
ikematsu_RS04275	COG2706	6-phosphogluconolactonase activity
ikematsu_RS04285	COG1686	Belongs to the peptidase S11 family
ikematsu_RS04305	COG2326	polyphosphate kinase activity
ikematsu_RS04310	COG0583	DNA-binding transcription factor activity
ikematsu_RS04330	COG1263	PTS System
ikematsu_RS04330	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ikematsu_RS04330	COG2190	(PTS) system
ikematsu_RS04350	COG0583	DNA-binding transcription factor activity
ikematsu_RS04355	COG0281	malic enzyme
ikematsu_RS04365	COG3976	FMN-binding domain protein
ikematsu_RS04365	COG0431	NADPH-dependent FMN reductase
ikematsu_RS04365	COG1053	succinate dehydrogenase
ikematsu_RS04370	COG0114	fumarate hydratase activity
ikematsu_RS04375	COG1053	succinate dehydrogenase
ikematsu_RS04380	COG0471	metal ion transport
ikematsu_RS04385	COG0583	DNA-binding transcription factor activity
ikematsu_RS04400	COG0657	acetylesterase activity
ikematsu_RS04405	COG0693	protein deglycase activity
ikematsu_RS04410	COG0392	lysyltransferase activity
ikematsu_RS04410	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
ikematsu_RS04420	COG0564	pseudouridine synthase activity
ikematsu_RS04435	COG2814	Major facilitator Superfamily
ikematsu_RS04490	COG1278	Cold shock
ikematsu_RS04520	COG0833	amino acid
ikematsu_RS04525	COG1428	Deoxynucleoside kinase
ikematsu_RS04555	COG1028	Short-chain dehydrogenase reductase Sdr
ikematsu_RS04560	COG1028	Short-chain dehydrogenase reductase Sdr
ikematsu_RS04570	COG1968	undecaprenyl-diphosphatase activity
ikematsu_RS04585	COG2171	N-acyltransferase activity
ikematsu_RS04600	COG1064	alcohol dehydrogenase
ikematsu_RS04605	COG4463	regulation of RNA biosynthetic process
ikematsu_RS04610	COG0542	response to heat
ikematsu_RS04620	COG0085	RNA polymerase activity
ikematsu_RS04625	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ikematsu_RS04630	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
ikematsu_RS04640	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
ikematsu_RS04645	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
ikematsu_RS04650	COG0049	tRNA binding
ikematsu_RS04655	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ikematsu_RS04660	COG0051	transcription antitermination factor activity, RNA binding
ikematsu_RS04665	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ikematsu_RS04670	COG0088	Forms part of the polypeptide exit tunnel
ikematsu_RS04675	COG0089	rRNA binding
ikematsu_RS04680	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ikematsu_RS04685	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ikematsu_RS04690	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
ikematsu_RS04695	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
ikematsu_RS04700	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ikematsu_RS04705	COG0255	Belongs to the universal ribosomal protein uL29 family
ikematsu_RS04715	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ikematsu_RS04720	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
ikematsu_RS04725	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ikematsu_RS04730	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
ikematsu_RS04735	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
ikematsu_RS04740	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
ikematsu_RS04745	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
ikematsu_RS04750	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ikematsu_RS04755	COG1841	ribosomal large subunit assembly
ikematsu_RS04760	COG0200	Binds to the 23S rRNA
ikematsu_RS04770	COG0563	adenylate kinase activity
ikematsu_RS04775	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ikematsu_RS04780	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ikematsu_RS04785	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ikematsu_RS04790	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
ikematsu_RS04795	COG0202	RNA polymerase activity
ikematsu_RS04800	COG0203	ribosomal protein L17
ikematsu_RS04805	COG1122	ATPase activity
ikematsu_RS04820	COG0101	tRNA pseudouridine synthase activity
ikematsu_RS04825	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
ikematsu_RS04830	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ikematsu_RS04845	COG1705	Flagellar rod assembly protein muramidase FlgJ
ikematsu_RS04850	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ikematsu_RS04865	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ikematsu_RS04870	COG4851	CamS sex pheromone cAM373 precursor
ikematsu_RS04875	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ikematsu_RS04880	COG0154	amidase activity
ikematsu_RS04885	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ikematsu_RS04890	COG1597	lipid kinase activity
ikematsu_RS04895	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ikematsu_RS04905	COG3328	transposase activity
ikematsu_RS04940	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ikematsu_RS04950	COG3328	transposase activity
ikematsu_RS04960	COG2801	Transposase and inactivated derivatives
ikematsu_RS04975	COG2801	Transposase and inactivated derivatives
ikematsu_RS04990	COG2801	Transposase and inactivated derivatives
ikematsu_RS05020	COG0673	inositol 2-dehydrogenase activity
ikematsu_RS05025	COG1757	Na H antiporter
ikematsu_RS05035	COG3760	aminoacyl-tRNA metabolism involved in translational fidelity
ikematsu_RS05055	COG2226	methyltransferase
ikematsu_RS05070	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ikematsu_RS05085	COG2814	Major facilitator Superfamily
ikematsu_RS05090	COG1846	Transcriptional regulator
ikematsu_RS05095	COG1316	TRANSCRIPTIONal
ikematsu_RS05105	COG0783	Belongs to the Dps family
ikematsu_RS05110	COG0488	(ABC) transporter
ikematsu_RS05115	COG4841	protein insertion into membrane
ikematsu_RS05150	COG0513	Belongs to the DEAD box helicase family
ikematsu_RS05165	COG2826	transposase and inactivated derivatives, IS30 family
ikematsu_RS05175	COG2246	polysaccharide biosynthetic process
ikematsu_RS05180	COG0716	FMN binding
ikematsu_RS05185	COG0024	Methionine aminopeptidase
ikematsu_RS05190	COG1368	sulfuric ester hydrolase activity
ikematsu_RS05195	COG1295	ribonuclease BN
ikematsu_RS05210	COG2137	regulation of response to DNA damage stimulus
ikematsu_RS05215	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ikematsu_RS05240	COG0562	UDP-galactopyranose mutase
ikematsu_RS05260	COG3328	transposase activity
ikematsu_RS05265	COG1705	Flagellar rod assembly protein muramidase FlgJ
ikematsu_RS05270	COG0791	NLP P60 protein
ikematsu_RS05280	COG0463	Glycosyl transferase, family 2
ikematsu_RS05285	COG0628	permease
ikematsu_RS05290	COG0463	Glycosyl transferase, family 2
ikematsu_RS05295	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
ikematsu_RS05300	COG0438	transferase activity, transferring glycosyl groups
ikematsu_RS05305	COG1215	transferase activity, transferring glycosyl groups
ikematsu_RS05315	COG1088	dTDP-glucose 4,6-dehydratase activity
ikematsu_RS05320	COG2188	Transcriptional regulator
ikematsu_RS05325	COG1131	(ABC) transporter
ikematsu_RS05345	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ikematsu_RS05360	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
ikematsu_RS05365	COG1335	isochorismatase
ikematsu_RS05375	COG0542	response to heat
ikematsu_RS05390	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ikematsu_RS05395	COG0438	transferase activity, transferring glycosyl groups
ikematsu_RS05400	COG0438	transferase activity, transferring glycosyl groups
ikematsu_RS05485	COG2826	transposase and inactivated derivatives, IS30 family
ikematsu_RS05500	COG2076	Multidrug Resistance protein
ikematsu_RS05505	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ikematsu_RS05510	COG0765	amino acid transport
ikematsu_RS05520	COG0602	queuosine metabolic process
ikematsu_RS05530	COG2233	PERMEase
ikematsu_RS05545	COG1607	acyl-coa hydrolase
ikematsu_RS05595	COG1113	amino acid transport
ikematsu_RS05605	COG2814	Major facilitator Superfamily
ikematsu_RS05610	COG2818	Glycosylase
ikematsu_RS05620	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ikematsu_RS05625	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
ikematsu_RS05630	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ikematsu_RS05635	COG0671	phosphoesterase, PA-phosphatase related
ikematsu_RS05640	COG0675	Transposase, IS605 OrfB family
ikematsu_RS05650	COG0495	leucyl-tRNA aminoacylation
ikematsu_RS05660	COG2244	polysaccharide biosynthetic process
ikematsu_RS05670	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ikematsu_RS05675	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ikematsu_RS05680	COG0589	response to stress
ikematsu_RS05690	COG1705	Flagellar rod assembly protein muramidase FlgJ
ikematsu_RS05690	COG1388	LysM domain
ikematsu_RS05695	COG1428	Deoxynucleoside kinase
ikematsu_RS05705	COG1609	Transcriptional regulator
ikematsu_RS05720	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ikematsu_RS05720	COG0302	gtp cyclohydrolase
ikematsu_RS05725	COG0302	gtp cyclohydrolase
ikematsu_RS05735	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ikematsu_RS05740	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ikematsu_RS05760	COG0018	arginyl-trna synthetase
ikematsu_RS05765	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ikematsu_RS05770	COG3679	Belongs to the UPF0342 family
ikematsu_RS05775	COG3481	metal-dependent phosphohydrolase, HD sub domain
ikematsu_RS05790	COG0537	adenosine 5'-monophosphoramidase activity
ikematsu_RS05795	COG1131	(ABC) transporter
ikematsu_RS05805	COG0220	tRNA (guanine-N7-)-methyltransferase activity
ikematsu_RS05815	COG3118	belongs to the thioredoxin family
ikematsu_RS05820	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ikematsu_RS05825	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ikematsu_RS05830	COG0670	Belongs to the BI1 family
ikematsu_RS05835	COG2826	transposase and inactivated derivatives, IS30 family
ikematsu_RS05850	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ikematsu_RS05855	COG0237	dephospho-CoA kinase activity
ikematsu_RS05860	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ikematsu_RS05870	COG1484	DNA-dependent DNA replication
ikematsu_RS05875	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
ikematsu_RS05880	COG0291	Belongs to the bacterial ribosomal protein bL35 family
ikematsu_RS05885	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
ikematsu_RS05905	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
ikematsu_RS05915	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ikematsu_RS05925	COG0799	negative regulation of ribosome biogenesis
ikematsu_RS05930	COG2226	methyltransferase
ikematsu_RS05935	COG1323	Belongs to the UPF0348 family
ikematsu_RS05945	COG0333	Belongs to the bacterial ribosomal protein bL32 family
ikematsu_RS05950	COG0745	RESPONSE REGULATOR receiver
ikematsu_RS05955	COG5002	protein histidine kinase activity
ikematsu_RS05965	COG0242	peptide deformylase activity
ikematsu_RS05970	COG0706	membrane insertase activity
ikematsu_RS05975	COG1254	Belongs to the acylphosphatase family
ikematsu_RS05980	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ikematsu_RS05990	COG1733	regulation of RNA biosynthetic process
ikematsu_RS05995	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
ikematsu_RS06000	COG0072	phenylalanine-tRNA ligase activity
ikematsu_RS06000	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ikematsu_RS06005	COG0572	uridine kinase
ikematsu_RS06010	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ikematsu_RS06020	COG0768	penicillin binding
ikematsu_RS06025	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ikematsu_RS06030	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ikematsu_RS06045	COG1940	carbohydrate kinase activity
ikematsu_RS06050	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ikematsu_RS06060	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ikematsu_RS06090	COG1309	transcriptional regulator
ikematsu_RS06095	COG0261	This protein binds to 23S rRNA in the presence of protein L20
ikematsu_RS06105	COG0211	Belongs to the bacterial ribosomal protein bL27 family
ikematsu_RS06110	COG0006	proline dipeptidase activity
ikematsu_RS06115	COG1302	Protein conserved in bacteria
ikematsu_RS06120	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ikematsu_RS06125	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ikematsu_RS06130	COG1570	exodeoxyribonuclease VII activity
ikematsu_RS06150	COG1438	arginine binding
ikematsu_RS06155	COG0497	DNA recombination
ikematsu_RS06170	COG1758	RNA polymerase activity
ikematsu_RS06175	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ikematsu_RS06180	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ikematsu_RS06185	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ikematsu_RS06190	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ikematsu_RS06190	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ikematsu_RS06200	COG0515	serine threonine protein kinase
ikematsu_RS06200	COG2815	serine threonine protein kinase
ikematsu_RS06205	COG1162	GTPase activity
ikematsu_RS06210	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ikematsu_RS06220	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ikematsu_RS06230	COG1461	Dihydroxyacetone kinase
ikematsu_RS06235	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ikematsu_RS06240	COG0416	fatty acid biosynthetic process
ikematsu_RS06245	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ikematsu_RS06250	COG0571	ribonuclease III activity
ikematsu_RS06255	COG1196	nuclear chromosome segregation
ikematsu_RS06260	COG0552	protein localization to endoplasmic reticulum
ikematsu_RS06265	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
ikematsu_RS06270	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ikematsu_RS06285	COG0745	RESPONSE REGULATOR receiver
ikematsu_RS06290	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ikematsu_RS06295	COG0573	inorganic phosphate transmembrane transporter activity
ikematsu_RS06300	COG0581	inorganic phosphate transmembrane transporter activity
ikematsu_RS06305	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ikematsu_RS06315	COG0228	four-way junction DNA binding
ikematsu_RS06320	COG1837	Belongs to the UPF0109 family
ikematsu_RS06325	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ikematsu_RS06330	COG0336	Belongs to the RNA methyltransferase TrmD family
ikematsu_RS06335	COG0531	amino acid
ikematsu_RS06340	COG0335	large ribosomal subunit rRNA binding
ikematsu_RS06360	COG1857	crispr-associated protein
ikematsu_RS06375	COG1518	maintenance of DNA repeat elements
ikematsu_RS06410	COG0163	prenyltransferase activity
ikematsu_RS06415	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
ikematsu_RS06465	COG4336	lyase activity
ikematsu_RS06475	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ikematsu_RS06480	COG0505	Belongs to the CarA family
ikematsu_RS06485	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ikematsu_RS06490	COG0167	dihydroorotate dehydrogenase activity
ikematsu_RS06495	COG0561	phosphatase activity
ikematsu_RS06500	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
ikematsu_RS06500	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ikematsu_RS06510	COG3328	transposase activity
ikematsu_RS06515	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ikematsu_RS06540	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ikematsu_RS06540	COG1199	ATP-dependent helicase activity
ikematsu_RS06565	COG0667	Aldo Keto reductase
ikematsu_RS06570	COG0697	spore germination
ikematsu_RS06575	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ikematsu_RS06580	COG3331	DNA recombination
ikematsu_RS06585	COG4474	Belongs to the UPF0398 family
ikematsu_RS06590	COG3599	regulation of cell shape
ikematsu_RS06610	COG1051	belongs to the nudix hydrolase family
ikematsu_RS06615	COG0116	Belongs to the methyltransferase superfamily
ikematsu_RS06640	COG0328	RNA-DNA hybrid ribonuclease activity
ikematsu_RS06655	COG0564	pseudouridine synthase activity
ikematsu_RS06660	COG0505	Belongs to the CarA family
ikematsu_RS06665	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ikematsu_RS06675	COG0583	DNA-binding transcription factor activity
ikematsu_RS06680	COG0300	oxidoreductase activity
ikematsu_RS06700	COG0798	PFAM Bile acid sodium symporter
ikematsu_RS06705	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ikematsu_RS06720	COG1293	RNA-binding protein homologous to eukaryotic snRNP
ikematsu_RS06725	COG1307	EDD domain protein, DegV family
ikematsu_RS06735	COG3022	response to hydroperoxide
ikematsu_RS06740	COG1418	mRNA catabolic process
ikematsu_RS06745	COG0702	epimerase
ikematsu_RS06755	COG0083	homoserine kinase activity
ikematsu_RS06760	COG0460	homoserine dehydrogenase
ikematsu_RS06770	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
ikematsu_RS06775	COG1687	branched-chain amino acid
ikematsu_RS06780	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ikematsu_RS06805	COG0095	Lipoate-protein ligase
ikematsu_RS06815	COG0583	DNA-binding transcription factor activity
ikematsu_RS06820	COG2814	Major facilitator Superfamily
ikematsu_RS06825	COG1253	flavin adenine dinucleotide binding
ikematsu_RS06835	COG0477	Major facilitator Superfamily
ikematsu_RS06845	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
ikematsu_RS06850	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ikematsu_RS06865	COG0475	glutathione-regulated potassium exporter activity
ikematsu_RS06865	COG0569	domain protein
ikematsu_RS06870	COG1942	4-Oxalocrotonate Tautomerase
ikematsu_RS06875	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ikematsu_RS06895	COG0675	Transposase, IS605 OrfB family
ikematsu_RS06915	COG0477	Major facilitator Superfamily
ikematsu_RS06935	COG0561	phosphatase activity
ikematsu_RS06945	COG3104	oligopeptide transport
ikematsu_RS06950	COG0738	Major facilitator superfamily
ikematsu_RS06955	COG0077	Prephenate dehydratase
ikematsu_RS06955	COG1605	Chorismate mutase
ikematsu_RS06960	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
ikematsu_RS06970	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
ikematsu_RS06975	COG0287	Prephenate dehydrogenase
ikematsu_RS06980	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ikematsu_RS06985	COG0436	Aminotransferase
ikematsu_RS06990	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ikematsu_RS07030	COG0719	Fe-S assembly protein
ikematsu_RS07035	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ikematsu_RS07040	COG0822	iron-sulfur transferase activity
ikematsu_RS07045	COG0719	Fe-S assembly protein
ikematsu_RS07055	COG2826	transposase and inactivated derivatives, IS30 family
ikematsu_RS07075	COG2151	metal-sulfur cluster biosynthetic enzyme
ikematsu_RS07080	COG1252	NADH dehydrogenase
ikematsu_RS07090	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ikematsu_RS07110	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ikematsu_RS07115	COG2223	nitrite transmembrane transporter activity
ikematsu_RS07120	COG2151	metal-sulfur cluster biosynthetic enzyme
ikematsu_RS07130	COG2226	methyltransferase
ikematsu_RS07135	COG0675	Transposase, IS605 OrfB family
ikematsu_RS07150	COG0436	Aminotransferase
ikematsu_RS07160	COG1609	Transcriptional regulator
ikematsu_RS07165	COG2610	gluconate transmembrane transporter activity
ikematsu_RS07185	COG3682	Transcriptional regulator
ikematsu_RS07225	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ikematsu_RS07265	COG0028	Belongs to the TPP enzyme family
ikematsu_RS07270	COG4619	ABC transporter
ikematsu_RS07275	COG0390	transport system, permease component
ikematsu_RS07280	COG0584	glycerophosphoryl diester phosphodiesterase
ikematsu_RS07285	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ikematsu_RS07300	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ikematsu_RS07305	COG0402	S-adenosylhomocysteine deaminase activity
ikematsu_RS07335	COG0076	glutamate decarboxylase activity
ikematsu_RS07365	COG3328	transposase activity
ikematsu_RS07385	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ikematsu_RS07390	COG2918	glutathione biosynthetic process
ikematsu_RS07390	COG1181	Belongs to the D-alanine--D-alanine ligase family
ikematsu_RS07395	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ikematsu_RS07400	COG3328	transposase activity
ikematsu_RS07430	COG3479	Phenolic acid decarboxylase
ikematsu_RS07435	COG1695	Transcriptional regulator
ikematsu_RS07440	COG0105	UTP biosynthetic process
ikematsu_RS07455	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ikematsu_RS07465	COG1113	amino acid transport
ikematsu_RS07470	COG2826	transposase and inactivated derivatives, IS30 family
ikematsu_RS07480	COG4690	dipeptidase activity
ikematsu_RS07490	COG1250	3-hydroxyacyl-CoA dehydrogenase
ikematsu_RS07520	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
ikematsu_RS07525	COG0730	response to heat
ikematsu_RS07530	COG0628	permease
ikematsu_RS07535	COG0183	Belongs to the thiolase family
ikematsu_RS07550	COG1053	succinate dehydrogenase
ikematsu_RS07550	COG3976	FMN-binding domain protein
ikematsu_RS07560	COG0697	spore germination
ikematsu_RS07575	COG2826	transposase and inactivated derivatives, IS30 family
ikematsu_RS07600	COG2848	UPF0210 protein
ikematsu_RS07610	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ikematsu_RS07615	COG0626	cystathionine gamma-synthase activity
ikematsu_RS07645	COG2271	Major facilitator Superfamily
ikematsu_RS07650	COG0318	PFAM AMP-dependent synthetase and ligase
ikematsu_RS07700	COG2390	Transcriptional regulator
ikematsu_RS07720	COG3052	prosthetic group binding
ikematsu_RS07780	COG1732	Glycine betaine
ikematsu_RS07810	COG1063	alcohol dehydrogenase
ikematsu_RS07815	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
ikematsu_RS07820	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
ikematsu_RS07825	COG4974	Belongs to the 'phage' integrase family
ikematsu_RS07845	COG4720	Psort location CytoplasmicMembrane, score
ikematsu_RS07850	COG0656	L-ascorbic acid biosynthetic process
ikematsu_RS07900	COG0477	Major facilitator Superfamily
ikematsu_RS07905	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ikematsu_RS07925	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ikematsu_RS07955	COG2814	Major facilitator Superfamily
ikematsu_RS07970	COG2223	nitrite transmembrane transporter activity
ikematsu_RS07975	COG1811	Na channel or pump
ikematsu_RS07980	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ikematsu_RS07995	COG0402	S-adenosylhomocysteine deaminase activity
ikematsu_RS08005	COG1956	GAF domain-containing protein
ikematsu_RS08015	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ikematsu_RS08035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ikematsu_RS08040	COG0187	DNA topoisomerase II activity
ikematsu_RS08045	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
ikematsu_RS08060	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ikematsu_RS08065	COG0758	DNA mediated transformation
ikematsu_RS08070	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ikematsu_RS08080	COG4479	Belongs to the UPF0346 family
ikematsu_RS08085	COG4698	Protein conserved in bacteria
ikematsu_RS08090	COG2755	lipolytic protein G-D-S-L family
ikematsu_RS08100	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ikematsu_RS08105	COG1307	EDD domain protein, DegV family
ikematsu_RS08110	COG1272	protein, Hemolysin III
ikematsu_RS08115	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
ikematsu_RS08120	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
ikematsu_RS08125	COG0488	(ABC) transporter
ikematsu_RS08130	COG0617	tRNA 3'-terminal CCA addition
ikematsu_RS08140	COG0457	Tetratricopeptide repeat
ikematsu_RS08150	COG1160	GTP binding
ikematsu_RS08155	COG0539	negative regulation of cytoplasmic translation
ikematsu_RS08160	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
ikematsu_RS08170	COG0514	ATP-dependent DNA helicase (RecQ)
ikematsu_RS08180	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
ikematsu_RS08185	COG1187	pseudouridine synthase activity
ikematsu_RS08190	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
ikematsu_RS08195	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
ikematsu_RS08205	COG4974	Belongs to the 'phage' integrase family
ikematsu_RS08220	COG0587	DNA-directed DNA polymerase activity
ikematsu_RS08230	COG2195	Cleaves the N-terminal amino acid of tripeptides
ikematsu_RS08235	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
ikematsu_RS08240	COG2384	SAM-dependent methyltransferase
ikematsu_RS08245	COG0569	domain protein
ikematsu_RS08250	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ikematsu_RS08255	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ikematsu_RS08260	COG0436	Aminotransferase
ikematsu_RS08265	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
ikematsu_RS08270	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ikematsu_RS08275	COG1473	amidohydrolase
ikematsu_RS08280	COG2171	N-acyltransferase activity
ikematsu_RS08285	COG0019	diaminopimelate decarboxylase activity
ikematsu_RS08290	COG0527	aspartate kinase activity
ikematsu_RS08295	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
ikematsu_RS08315	COG2826	transposase and inactivated derivatives, IS30 family
ikematsu_RS08320	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ikematsu_RS08325	COG0358	DNA primase activity
ikematsu_RS08330	COG0751	glycine-tRNA ligase activity
ikematsu_RS08335	COG0752	glycyl-tRNA synthetase alpha subunit
ikematsu_RS08340	COG1381	Involved in DNA repair and RecF pathway recombination
ikematsu_RS08345	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ikematsu_RS08350	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
ikematsu_RS08355	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
ikematsu_RS08360	COG1702	phosphate starvation-inducible protein PhoH
ikematsu_RS08365	COG1610	YqeY-like protein
ikematsu_RS08370	COG0828	Belongs to the bacterial ribosomal protein bS21 family
ikematsu_RS08380	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
ikematsu_RS08385	COG0124	histidyl-tRNA synthetase
ikematsu_RS08395	COG0860	N-Acetylmuramoyl-L-alanine amidase
ikematsu_RS08400	COG3001	Fructosamine kinase
ikematsu_RS08405	COG2040	homocysteine
ikematsu_RS08410	COG0833	amino acid
ikematsu_RS08415	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
ikematsu_RS08420	COG0460	homoserine dehydrogenase
ikematsu_RS08435	COG1126	abc transporter atp-binding protein
ikematsu_RS08440	COG0765	amino acid transport
ikematsu_RS08445	COG0765	amino acid transport
ikematsu_RS08450	COG2079	MmgE PrpD family protein
ikematsu_RS08455	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ikematsu_RS08460	COG1473	amidohydrolase
ikematsu_RS08465	COG1126	abc transporter atp-binding protein
ikematsu_RS08470	COG0765	amino acid transport
ikematsu_RS08475	COG0456	acetyltransferase
ikematsu_RS08480	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ikematsu_RS08485	COG0626	cystathionine gamma-synthase activity
ikematsu_RS08490	COG0626	cystathionine gamma-synthase activity
ikematsu_RS08500	COG1490	D-aminoacyl-tRNA deacylase activity
ikematsu_RS08505	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ikematsu_RS08515	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ikematsu_RS08520	COG2264	protein methyltransferase activity
ikematsu_RS08530	COG0675	Transposase, IS605 OrfB family
ikematsu_RS08540	COG0039	L-malate dehydrogenase activity
ikematsu_RS08560	COG1609	Transcriptional regulator
ikematsu_RS08565	COG1621	beta-fructofuranosidase activity
ikematsu_RS08585	COG0657	acetylesterase activity
ikematsu_RS08590	COG0657	acetylesterase activity
ikematsu_RS08605	COG1518	maintenance of DNA repeat elements
ikematsu_RS08620	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
ikematsu_RS08625	COG0351	phosphomethylpyrimidine kinase
ikematsu_RS08630	COG0352	thiamine-phosphate diphosphorylase activity
ikematsu_RS08635	COG0351	phosphomethylpyrimidine kinase
ikematsu_RS08650	COG0493	'glutamate synthase
ikematsu_RS08655	COG0067	glutamate synthase
ikematsu_RS08655	COG0069	glutamate synthase activity
ikematsu_RS08655	COG0070	glutamate synthase
ikematsu_RS08675	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ikematsu_RS08680	COG1464	Belongs to the NlpA lipoprotein family
ikematsu_RS08690	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ikematsu_RS08695	COG1811	Na channel or pump
ikematsu_RS08715	COG1104	cysteine desulfurase activity
ikematsu_RS08725	COG0745	RESPONSE REGULATOR receiver
ikematsu_RS08740	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ikematsu_RS08740	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ikematsu_RS08745	COG0307	riboflavin synthase, alpha
ikematsu_RS08755	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
ikematsu_RS08770	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ikematsu_RS08775	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
ikematsu_RS08780	COG0667	Aldo Keto reductase
ikematsu_RS08785	COG0406	alpha-ribazole phosphatase activity
ikematsu_RS08795	COG0481	GTPase activity
ikematsu_RS08800	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ikematsu_RS08805	COG0140	phosphoribosyl-ATP diphosphatase activity
ikematsu_RS08810	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ikematsu_RS08815	COG0107	imidazoleglycerol-phosphate synthase activity
ikematsu_RS08820	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
ikematsu_RS08825	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ikematsu_RS08830	COG0131	Imidazoleglycerol-phosphate dehydratase
ikematsu_RS08835	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ikematsu_RS08840	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
ikematsu_RS08845	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
ikematsu_RS08850	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
ikematsu_RS08860	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ikematsu_RS08865	COG0484	heat shock protein binding
ikematsu_RS08870	COG0443	Heat shock 70 kDa protein
ikematsu_RS08875	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ikematsu_RS08880	COG1420	regulation of RNA biosynthetic process
ikematsu_RS08900	COG2801	Transposase and inactivated derivatives
ikematsu_RS08910	COG1113	amino acid transport
ikematsu_RS08915	COG3048	D-serine ammonia-lyase activity
ikematsu_RS08920	COG2826	transposase and inactivated derivatives, IS30 family
ikematsu_RS08930	COG3759	membrane
ikematsu_RS08985	COG3328	transposase activity
ikematsu_RS08990	COG2814	Major facilitator Superfamily
ikematsu_RS08995	COG0196	riboflavin kinase activity
ikematsu_RS09000	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
ikematsu_RS09005	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
ikematsu_RS09010	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
ikematsu_RS09020	COG2740	Nucleic-acid-binding protein implicated in transcription termination
ikematsu_RS09025	COG0195	Participates in both transcription termination and antitermination
ikematsu_RS09030	COG0779	Required for maturation of 30S ribosomal subunits
ikematsu_RS09035	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ikematsu_RS09040	COG0505	Belongs to the CarA family
ikematsu_RS09045	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ikematsu_RS09050	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
ikematsu_RS09055	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ikematsu_RS09060	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ikematsu_RS09065	COG2176	DNA-directed DNA polymerase activity
ikematsu_RS09070	COG0442	prolyl-tRNA aminoacylation
ikematsu_RS09075	COG0750	zinc metalloprotease
ikematsu_RS09080	COG4589	Belongs to the CDS family
ikematsu_RS09085	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ikematsu_RS09090	COG0233	cytoplasmic translational termination
ikematsu_RS09100	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ikematsu_RS09105	COG0052	Belongs to the universal ribosomal protein uS2 family
ikematsu_RS09110	COG2827	Endonuclease containing a URI domain
ikematsu_RS09115	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
ikematsu_RS09120	COG0204	Acyl-transferase
ikematsu_RS09125	COG3763	UPF0154 protein
ikematsu_RS09130	COG4224	UPF0291 protein
ikematsu_RS09135	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ikematsu_RS09140	COG3425	synthase
ikematsu_RS09145	COG0247	lactate metabolic process
ikematsu_RS09150	COG1139	Iron-sulfur cluster binding protein
ikematsu_RS09155	COG1556	Lactate utilization protein
ikematsu_RS09170	COG2151	metal-sulfur cluster biosynthetic enzyme
ikematsu_RS09175	COG1760	l-serine dehydratase
ikematsu_RS09180	COG1760	l-serine dehydratase
ikematsu_RS09205	COG2826	transposase and inactivated derivatives, IS30 family
ikematsu_RS09250	COG3328	transposase activity
ikematsu_RS09255	COG0367	asparagine synthase
ikematsu_RS09260	COG2814	Major facilitator Superfamily
ikematsu_RS09290	COG1396	sequence-specific DNA binding
ikematsu_RS09310	COG2249	NAD(P)H dehydrogenase (quinone) activity
ikematsu_RS09330	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ikematsu_RS09340	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ikematsu_RS09345	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
ikematsu_RS09345	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ikematsu_RS09350	COG0300	oxidoreductase activity
ikematsu_RS09355	COG1234	tRNA 3'-trailer cleavage
ikematsu_RS09360	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ikematsu_RS09365	COG0322	excinuclease ABC activity
ikematsu_RS09370	COG1126	abc transporter atp-binding protein
ikematsu_RS09385	COG0218	Necessary for normal cell division and for the maintenance of normal septation
ikematsu_RS09390	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ikematsu_RS09395	COG0544	peptidyl-prolyl cis-trans isomerase activity
ikematsu_RS09400	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ikematsu_RS09430	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
ikematsu_RS09435	COG0268	Binds directly to 16S ribosomal RNA
ikematsu_RS09440	COG1466	dna polymerase III delta subunit
ikematsu_RS09445	COG0582	viral genome integration into host DNA
ikematsu_RS09535	COG0366	Alpha amylase catalytic
ikematsu_RS09535	COG5263	repeat protein
ikematsu_RS09560	COG2333	competence protein COMEC
ikematsu_RS09560	COG0658	competence protein
ikematsu_RS09565	COG2131	deaminase
ikematsu_RS09570	COG1596	polysaccharide export
ikematsu_RS09570	COG1555	photosystem II stabilization
ikematsu_RS09575	COG3480	Lon protease (S16) C-terminal proteolytic domain
ikematsu_RS09580	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
ikematsu_RS09585	COG0742	ribosomal rna small subunit methyltransferase
ikematsu_RS09590	COG4471	UPF0298 protein
ikematsu_RS09600	COG1217	gtp-binding protein TYPA
ikematsu_RS09605	COG0483	inositol monophosphate 1-phosphatase activity
ikematsu_RS09610	COG4476	Belongs to the UPF0223 family
ikematsu_RS09615	COG0242	peptide deformylase activity
ikematsu_RS09625	COG5503	Protein of unknown function (DUF1447)
ikematsu_RS09630	COG1597	lipid kinase activity
ikematsu_RS09635	COG1393	Belongs to the ArsC family
ikematsu_RS09640	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ikematsu_RS09655	COG0406	alpha-ribazole phosphatase activity
ikematsu_RS09670	COG0482	sulfurtransferase activity
ikematsu_RS09680	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
ikematsu_RS09695	COG1278	Cold shock
ikematsu_RS09700	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
ikematsu_RS09705	COG3599	regulation of cell shape
ikematsu_RS09720	COG1799	cell septum assembly
ikematsu_RS09725	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ikematsu_RS09730	COG0849	cell division
ikematsu_RS09740	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ikematsu_RS09745	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ikematsu_RS09750	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ikematsu_RS09755	COG0768	penicillin binding
ikematsu_RS09765	COG0275	rRNA processing
ikematsu_RS09770	COG2001	Belongs to the MraZ family
ikematsu_RS09790	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
ikematsu_RS09810	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ikematsu_RS09840	COG3775	system Galactitol-specific IIC component
ikematsu_RS09845	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ikematsu_RS09850	COG0446	pyridine nucleotide-disulphide oxidoreductase
ikematsu_RS09870	COG0582	viral genome integration into host DNA
ikematsu_RS09875	COG1192	Involved in chromosome partitioning
ikematsu_RS09900	COG2217	Heavy metal translocating P-type atpase