locus-tag	class	description
LRIRT_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
LRIRT_RS00010	COG0592	DNA-directed DNA polymerase activity
LRIRT_RS00015	COG2501	S4 domain
LRIRT_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
LRIRT_RS00025	COG0187	DNA topoisomerase II activity
LRIRT_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
LRIRT_RS00035	COG0360	Binds together with S18 to 16S ribosomal RNA
LRIRT_RS00040	COG0629	single-stranded DNA binding
LRIRT_RS00045	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
LRIRT_RS00055	COG0359	binds to the 23S rRNA
LRIRT_RS00060	COG0305	Participates in initiation and elongation during chromosome replication
LRIRT_RS00065	COG2814	Major facilitator Superfamily
LRIRT_RS00075	COG2326	polyphosphate kinase activity
LRIRT_RS00095	COG1132	(ABC) transporter
LRIRT_RS00105	COG0745	RESPONSE REGULATOR receiver
LRIRT_RS00120	COG4853	Protein conserved in bacteria
LRIRT_RS00125	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
LRIRT_RS00130	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LRIRT_RS00135	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
LRIRT_RS00145	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
LRIRT_RS00165	COG4975	Glucose uptake
LRIRT_RS00175	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
LRIRT_RS00180	COG1012	belongs to the aldehyde dehydrogenase family
LRIRT_RS00190	COG1136	(ABC) transporter
LRIRT_RS00195	COG0577	efflux transmembrane transporter activity
LRIRT_RS00225	COG0436	Aminotransferase
LRIRT_RS00250	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LRIRT_RS00255	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
LRIRT_RS00260	COG1074	ATP-dependent DNA helicase activity
LRIRT_RS00265	COG1609	Transcriptional regulator
LRIRT_RS00270	COG0183	Belongs to the thiolase family
LRIRT_RS00280	COG1554	hydrolase, family 65, central catalytic
LRIRT_RS00285	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LRIRT_RS00295	COG2357	RelA SpoT domain protein
LRIRT_RS00300	COG0745	RESPONSE REGULATOR receiver
LRIRT_RS00305	COG5002	protein histidine kinase activity
LRIRT_RS00325	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
LRIRT_RS00330	COG0656	L-ascorbic acid biosynthetic process
LRIRT_RS00345	COG0446	pyridine nucleotide-disulphide oxidoreductase
LRIRT_RS00355	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
LRIRT_RS00375	COG0675	Transposase, IS605 OrfB family
LRIRT_RS00385	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
LRIRT_RS00415	COG0438	transferase activity, transferring glycosyl groups
LRIRT_RS00425	COG0366	Alpha amylase catalytic
LRIRT_RS00435	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
LRIRT_RS00440	COG0505	Belongs to the CarA family
LRIRT_RS00455	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LRIRT_RS00460	COG0431	NADPH-dependent FMN reductase
LRIRT_RS00460	COG3976	FMN-binding domain protein
LRIRT_RS00460	COG1053	succinate dehydrogenase
LRIRT_RS00465	COG0431	NADPH-dependent FMN reductase
LRIRT_RS00495	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
LRIRT_RS00500	COG0765	amino acid transport
LRIRT_RS00510	COG1113	amino acid transport
LRIRT_RS00515	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LRIRT_RS00525	COG1250	3-hydroxyacyl-CoA dehydrogenase
LRIRT_RS00530	COG0357	Ribosomal RNA small subunit methyltransferase G
LRIRT_RS00535	COG1475	DNA binding
LRIRT_RS00540	COG1192	Involved in chromosome partitioning
LRIRT_RS00545	COG1475	DNA binding
LRIRT_RS00555	COG0012	GTP binding
LRIRT_RS00570	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
LRIRT_RS00575	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
LRIRT_RS00580	COG0813	purine-nucleoside phosphorylase activity
LRIRT_RS00585	COG2390	Transcriptional regulator
LRIRT_RS00590	COG0517	IMP dehydrogenase activity
LRIRT_RS00590	COG0516	GMP reductase activity
LRIRT_RS00595	COG0745	RESPONSE REGULATOR receiver
LRIRT_RS00600	COG5002	protein histidine kinase activity
LRIRT_RS00620	COG0540	Belongs to the ATCase OTCase family
LRIRT_RS00630	COG0167	dihydroorotate dehydrogenase activity
LRIRT_RS00635	COG0284	orotidine-5'-phosphate decarboxylase activity
LRIRT_RS00640	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
LRIRT_RS00650	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LRIRT_RS00655	COG0628	permease
LRIRT_RS00660	COG2759	Belongs to the formate--tetrahydrofolate ligase family
LRIRT_RS00665	COG0028	Belongs to the TPP enzyme family
LRIRT_RS00670	COG3527	Alpha-acetolactate decarboxylase
LRIRT_RS00675	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
LRIRT_RS00680	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
LRIRT_RS00685	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
LRIRT_RS00690	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
LRIRT_RS00695	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LRIRT_RS00700	COG0047	phosphoribosylformylglycinamidine synthase activity
LRIRT_RS00705	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LRIRT_RS00710	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
LRIRT_RS00715	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
LRIRT_RS00720	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
LRIRT_RS00725	COG0138	bifunctional purine biosynthesis protein purh
LRIRT_RS00730	COG0151	Belongs to the GarS family
LRIRT_RS00735	COG0588	phosphoglycerate mutase activity
LRIRT_RS00745	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
LRIRT_RS00800	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
LRIRT_RS00805	COG1335	isochorismatase
LRIRT_RS00810	COG1397	ADP-ribosylglycohydrolase
LRIRT_RS00820	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LRIRT_RS00825	COG1733	regulation of RNA biosynthetic process
LRIRT_RS00830	COG0477	Major facilitator Superfamily
LRIRT_RS00855	COG1757	Na H antiporter
LRIRT_RS00865	COG3545	Serine hydrolase
LRIRT_RS00875	COG0149	triose-phosphate isomerase activity
LRIRT_RS00885	COG4989	oxidoreductase activity
LRIRT_RS00905	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LRIRT_RS00930	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
LRIRT_RS00940	COG1959	2 iron, 2 sulfur cluster binding
LRIRT_RS00950	COG1174	glycine betaine transport
LRIRT_RS00955	COG1125	glycine betaine transport
LRIRT_RS00955	COG0517	IMP dehydrogenase activity
LRIRT_RS01000	COG2814	Major facilitator Superfamily
LRIRT_RS01005	COG1053	succinate dehydrogenase
LRIRT_RS01005	COG3976	FMN-binding domain protein
LRIRT_RS01010	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
LRIRT_RS01015	COG0531	amino acid
LRIRT_RS01035	COG3973	AAA domain
LRIRT_RS01055	COG0248	Ppx GppA phosphatase
LRIRT_RS01070	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
LRIRT_RS01075	COG1801	Protein of unknown function DUF72
LRIRT_RS01080	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LRIRT_RS01080	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LRIRT_RS01085	COG0084	hydrolase, TatD family'
LRIRT_RS01090	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
LRIRT_RS01095	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
LRIRT_RS01100	COG4466	Protein conserved in bacteria
LRIRT_RS01105	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
LRIRT_RS01115	COG1121	(ABC) transporter
LRIRT_RS01120	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LRIRT_RS01125	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LRIRT_RS01130	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
LRIRT_RS01135	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
LRIRT_RS01150	COG1078	dGTPase activity
LRIRT_RS01155	COG0095	Lipoate-protein ligase
LRIRT_RS01175	COG3343	RNA polymerase activity
LRIRT_RS01180	COG0504	CTP synthase activity
LRIRT_RS01190	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LRIRT_RS01195	COG0254	rRNA binding
LRIRT_RS01200	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LRIRT_RS01215	COG0149	triose-phosphate isomerase activity
LRIRT_RS01220	COG0191	fructose-bisphosphate aldolase activity
LRIRT_RS01225	COG0406	alpha-ribazole phosphatase activity
LRIRT_RS01230	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LRIRT_RS01235	COG1704	LemA family
LRIRT_RS01240	COG0501	Belongs to the peptidase M48B family
LRIRT_RS01245	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LRIRT_RS01275	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
LRIRT_RS01285	COG1696	Membrane protein involved in D-alanine export
LRIRT_RS01290	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LRIRT_RS01300	COG0736	holo-[acyl-carrier-protein] synthase activity
LRIRT_RS01305	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LRIRT_RS01310	COG2337	Toxic component of a toxin-antitoxin (TA) module
LRIRT_RS01320	COG0402	S-adenosylhomocysteine deaminase activity
LRIRT_RS01335	COG0193	aminoacyl-tRNA hydrolase activity
LRIRT_RS01340	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
LRIRT_RS01345	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
LRIRT_RS01355	COG1098	S1 RNA binding domain
LRIRT_RS01360	COG0037	tRNA processing
LRIRT_RS01375	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
LRIRT_RS01380	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LRIRT_RS01385	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
LRIRT_RS01430	COG4372	Transposase
LRIRT_RS01445	COG3104	oligopeptide transport
LRIRT_RS01470	COG2814	Major facilitator Superfamily
LRIRT_RS01480	COG1794	racemase activity, acting on amino acids and derivatives
LRIRT_RS01485	COG2188	Transcriptional regulator
LRIRT_RS01490	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
LRIRT_RS01495	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
LRIRT_RS01500	COG2183	response to ionizing radiation
LRIRT_RS01505	COG3091	SprT-like family
LRIRT_RS01515	COG3250	beta-galactosidase activity
LRIRT_RS01520	COG3250	beta-galactosidase activity
LRIRT_RS01530	COG0588	phosphoglycerate mutase activity
LRIRT_RS01540	COG0626	cystathionine gamma-synthase activity
LRIRT_RS01545	COG0765	amino acid transport
LRIRT_RS01550	COG1126	abc transporter atp-binding protein
LRIRT_RS01555	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LRIRT_RS01565	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
LRIRT_RS01575	COG0756	dUTP diphosphatase activity
LRIRT_RS01580	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
LRIRT_RS01585	COG4956	integral membrane protein (PIN domain superfamily)
LRIRT_RS01590	COG0215	cysteine-tRNA ligase activity
LRIRT_RS01595	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
LRIRT_RS01600	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LRIRT_RS01610	COG0250	Participates in transcription elongation, termination and antitermination
LRIRT_RS01615	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
LRIRT_RS01625	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LRIRT_RS01630	COG1215	transferase activity, transferring glycosyl groups
LRIRT_RS01635	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
LRIRT_RS01640	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
LRIRT_RS01645	COG0222	ribosome binding
LRIRT_RS01660	COG1970	mechanosensitive ion channel activity
LRIRT_RS01665	COG1695	Transcriptional regulator
LRIRT_RS01680	COG1012	belongs to the aldehyde dehydrogenase family
LRIRT_RS01680	COG1454	alcohol dehydrogenase
LRIRT_RS01690	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LRIRT_RS01695	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
LRIRT_RS01700	COG0590	tRNA wobble adenosine to inosine editing
LRIRT_RS01705	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
LRIRT_RS01715	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
LRIRT_RS01725	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
LRIRT_RS01730	COG3870	Protein conserved in bacteria
LRIRT_RS01735	COG0470	DNA polymerase III
LRIRT_RS01740	COG4467	Involved in initiation control of chromosome replication
LRIRT_RS01760	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
LRIRT_RS01770	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LRIRT_RS01785	COG1214	PFAM Peptidase M22, glycoprotease
LRIRT_RS01795	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
LRIRT_RS01800	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
LRIRT_RS01805	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
LRIRT_RS01815	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LRIRT_RS01820	COG0436	Aminotransferase
LRIRT_RS01825	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
LRIRT_RS01835	COG0488	(ABC) transporter
LRIRT_RS01840	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
LRIRT_RS01850	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
LRIRT_RS01855	COG0459	protein refolding
LRIRT_RS01865	COG0531	amino acid
LRIRT_RS01870	COG0531	amino acid
LRIRT_RS01880	COG1846	Transcriptional regulator
LRIRT_RS01885	COG0477	Major facilitator Superfamily
LRIRT_RS01890	COG1739	Uncharacterized protein family UPF0029
LRIRT_RS01895	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
LRIRT_RS01910	COG0653	protein targeting
LRIRT_RS01925	COG1950	PFAM Membrane protein of
LRIRT_RS01930	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
LRIRT_RS01935	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
LRIRT_RS01940	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
LRIRT_RS01945	COG1210	Utp--glucose-1-phosphate uridylyltransferase
LRIRT_RS01950	COG1556	Lactate utilization protein
LRIRT_RS01955	COG1139	Iron-sulfur cluster binding protein
LRIRT_RS01960	COG0247	lactate metabolic process
LRIRT_RS01965	COG0492	ferredoxin-NADP+ reductase activity
LRIRT_RS01970	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LRIRT_RS01975	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LRIRT_RS01980	COG1607	acyl-coa hydrolase
LRIRT_RS01985	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LRIRT_RS02000	COG0556	nucleotide-excision repair
LRIRT_RS02005	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LRIRT_RS02010	COG0531	amino acid
LRIRT_RS02015	COG1660	Displays ATPase and GTPase activities
LRIRT_RS02020	COG0391	Required for morphogenesis under gluconeogenic growth conditions
LRIRT_RS02025	COG1481	regulation of sporulation
LRIRT_RS02030	COG0740	serine-type endopeptidase activity
LRIRT_RS02055	COG0149	triose-phosphate isomerase activity
LRIRT_RS02060	COG0148	phosphopyruvate hydratase activity
LRIRT_RS02070	COG1113	amino acid transport
LRIRT_RS02075	COG0038	chloride channel
LRIRT_RS02090	COG0557	exoribonuclease II activity
LRIRT_RS02095	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
LRIRT_RS02105	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
LRIRT_RS02110	COG0280	phosphate acetyltransferase
LRIRT_RS02115	COG0802	atpase or kinase
LRIRT_RS02130	COG2176	DNA-directed DNA polymerase activity
LRIRT_RS02135	COG0812	UDP-N-acetylmuramate dehydrogenase activity
LRIRT_RS02145	COG1869	D-ribose catabolic process
LRIRT_RS02150	COG0738	Major facilitator superfamily
LRIRT_RS02165	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LRIRT_RS02170	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LRIRT_RS02180	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
LRIRT_RS02180	COG2755	lipolytic protein G-D-S-L family
LRIRT_RS02190	COG0561	phosphatase activity
LRIRT_RS02200	COG0745	RESPONSE REGULATOR receiver
LRIRT_RS02205	COG3850	Histidine kinase
LRIRT_RS02205	COG5002	protein histidine kinase activity
LRIRT_RS02210	COG4975	Glucose uptake
LRIRT_RS02215	COG0110	maltose O-acetyltransferase activity
LRIRT_RS02220	COG0166	Belongs to the GPI family
LRIRT_RS02245	COG2201	protein-glutamate methylesterase activity
LRIRT_RS02250	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
LRIRT_RS02365	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LRIRT_RS02370	COG2235	arginine
LRIRT_RS02395	COG3442	glutamine amidotransferase
LRIRT_RS02400	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LRIRT_RS02405	COG1435	thymidine kinase activity
LRIRT_RS02415	COG2890	protein-(glutamine-N5) methyltransferase activity
LRIRT_RS02420	COG0009	L-threonylcarbamoyladenylate synthase
LRIRT_RS02425	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LRIRT_RS02430	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
LRIRT_RS02450	COG2233	PERMEase
LRIRT_RS02455	COG0356	it plays a direct role in the translocation of protons across the membrane
LRIRT_RS02460	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LRIRT_RS02465	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
LRIRT_RS02470	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LRIRT_RS02475	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
LRIRT_RS02480	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
LRIRT_RS02485	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
LRIRT_RS02490	COG0355	proton-transporting ATP synthase activity, rotational mechanism
LRIRT_RS02500	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LRIRT_RS02505	COG1077	Cell shape determining protein MreB Mrl
LRIRT_RS02515	COG0772	Belongs to the SEDS family
LRIRT_RS02530	COG1181	Belongs to the D-alanine--D-alanine ligase family
LRIRT_RS02550	COG0235	Class ii aldolase
LRIRT_RS02555	COG2160	L-arabinose isomerase activity
LRIRT_RS02560	COG0110	maltose O-acetyltransferase activity
LRIRT_RS02565	COG0656	L-ascorbic acid biosynthetic process
LRIRT_RS02570	COG1609	Transcriptional regulator
LRIRT_RS02575	COG0589	response to stress
LRIRT_RS02585	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
LRIRT_RS02600	COG0346	lactoylglutathione lyase activity
LRIRT_RS02610	COG3022	response to hydroperoxide
LRIRT_RS02615	COG0028	Belongs to the TPP enzyme family
LRIRT_RS02640	COG2252	PERMEase
LRIRT_RS02645	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
LRIRT_RS02650	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
LRIRT_RS02655	COG1104	cysteine desulfurase activity
LRIRT_RS02660	COG0301	tRNA thio-modification
LRIRT_RS02665	COG0525	valine-tRNA ligase activity
LRIRT_RS02670	COG1271	oxidase subunit
LRIRT_RS02675	COG1294	oxidase, subunit
LRIRT_RS02680	COG4988	ABC transporter
LRIRT_RS02685	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
LRIRT_RS02690	COG1252	NADH dehydrogenase
LRIRT_RS02695	COG0285	dihydrofolate synthase activity
LRIRT_RS02705	COG1077	Cell shape determining protein MreB Mrl
LRIRT_RS02710	COG1792	Involved in formation and maintenance of cell shape
LRIRT_RS02720	COG0765	amino acid transport
LRIRT_RS02730	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LRIRT_RS02735	COG0612	Peptidase, M16
LRIRT_RS02740	COG0612	Peptidase, M16
LRIRT_RS02745	COG1426	Protein conserved in bacteria
LRIRT_RS02750	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
LRIRT_RS02755	COG1058	Belongs to the CinA family
LRIRT_RS02755	COG1546	Belongs to the CinA family
LRIRT_RS02760	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
LRIRT_RS02770	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
LRIRT_RS02775	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
LRIRT_RS02780	COG0632	four-way junction helicase activity
LRIRT_RS02785	COG2255	four-way junction helicase activity
LRIRT_RS02790	COG0343	queuine tRNA-ribosyltransferase activity
LRIRT_RS02795	COG1862	Preprotein translocase
LRIRT_RS02800	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
LRIRT_RS02805	COG0513	Belongs to the DEAD box helicase family
LRIRT_RS02810	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LRIRT_RS02815	COG4472	Bacterial protein of unknown function (DUF965)
LRIRT_RS02820	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
LRIRT_RS02825	COG3906	Belongs to the UPF0473 family
LRIRT_RS02835	COG1193	negative regulation of DNA recombination
LRIRT_RS02840	COG3118	belongs to the thioredoxin family
LRIRT_RS02850	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
LRIRT_RS02855	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
LRIRT_RS02860	COG0622	Phosphoesterase
LRIRT_RS02870	COG0561	phosphatase activity
LRIRT_RS02875	COG0668	transmembrane transport
LRIRT_RS02895	COG1609	Transcriptional regulator
LRIRT_RS02905	COG0217	transcriptional regulatory protein
LRIRT_RS02910	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LRIRT_RS02915	COG1459	type II secretion system
LRIRT_RS02920	COG4537	Required for transformation and DNA binding
LRIRT_RS02940	COG0827	DNA restriction-modification system
LRIRT_RS02945	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
LRIRT_RS02955	COG4470	Protein conserved in bacteria
LRIRT_RS02960	COG0647	UMP catabolic process
LRIRT_RS02970	COG0586	Pfam SNARE associated Golgi protein
LRIRT_RS03105	COG1393	Belongs to the ArsC family
LRIRT_RS03110	COG4862	establishment of competence for transformation
LRIRT_RS03120	COG4690	dipeptidase activity
LRIRT_RS03130	COG2357	RelA SpoT domain protein
LRIRT_RS03135	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
LRIRT_RS03140	COG0564	pseudouridine synthase activity
LRIRT_RS03170	COG4372	Transposase
LRIRT_RS03190	COG2706	6-phosphogluconolactonase activity
LRIRT_RS03195	COG2226	methyltransferase
LRIRT_RS03200	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
LRIRT_RS03205	COG1674	ftsk spoiiie
LRIRT_RS03215	COG2001	Belongs to the MraZ family
LRIRT_RS03220	COG0275	rRNA processing
LRIRT_RS03230	COG0768	penicillin binding
LRIRT_RS03235	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LRIRT_RS03240	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
LRIRT_RS03245	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
LRIRT_RS03255	COG0849	cell division
LRIRT_RS03265	COG1799	cell septum assembly
LRIRT_RS03275	COG2302	S4 RNA-binding domain
LRIRT_RS03280	COG3599	regulation of cell shape
LRIRT_RS03290	COG1278	Cold shock
LRIRT_RS03295	COG0494	nUDIX hydrolase
LRIRT_RS03305	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
LRIRT_RS03310	COG1104	cysteine desulfurase activity
LRIRT_RS03320	COG0482	sulfurtransferase activity
LRIRT_RS03325	COG0406	alpha-ribazole phosphatase activity
LRIRT_RS03335	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LRIRT_RS03340	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
LRIRT_RS03350	COG0527	aspartate kinase activity
LRIRT_RS03355	COG0019	diaminopimelate decarboxylase activity
LRIRT_RS03360	COG2171	N-acyltransferase activity
LRIRT_RS03365	COG1473	amidohydrolase
LRIRT_RS03370	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LRIRT_RS03375	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
LRIRT_RS03380	COG0436	Aminotransferase
LRIRT_RS03385	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
LRIRT_RS03400	COG2610	gluconate transmembrane transporter activity
LRIRT_RS03405	COG1929	Belongs to the glycerate kinase type-1 family
LRIRT_RS03430	COG1597	lipid kinase activity
LRIRT_RS03435	COG5503	Protein of unknown function (DUF1447)
LRIRT_RS03445	COG0242	peptide deformylase activity
LRIRT_RS03450	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
LRIRT_RS03475	COG0483	inositol monophosphate 1-phosphatase activity
LRIRT_RS03480	COG1217	gtp-binding protein TYPA
LRIRT_RS03485	COG0772	Belongs to the SEDS family
LRIRT_RS03490	COG4471	UPF0298 protein
LRIRT_RS03495	COG0742	ribosomal rna small subunit methyltransferase
LRIRT_RS03500	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
LRIRT_RS03505	COG3480	Lon protease (S16) C-terminal proteolytic domain
LRIRT_RS03510	COG1555	photosystem II stabilization
LRIRT_RS03515	COG2131	deaminase
LRIRT_RS03520	COG2333	competence protein COMEC
LRIRT_RS03520	COG0658	competence protein
LRIRT_RS03525	COG1466	dna polymerase III delta subunit
LRIRT_RS03530	COG0268	Binds directly to 16S ribosomal RNA
LRIRT_RS03535	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
LRIRT_RS03550	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LRIRT_RS03555	COG0544	peptidyl-prolyl cis-trans isomerase activity
LRIRT_RS03560	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
LRIRT_RS03565	COG0218	Necessary for normal cell division and for the maintenance of normal septation
LRIRT_RS03575	COG0322	excinuclease ABC activity
LRIRT_RS03580	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
LRIRT_RS03585	COG1234	tRNA 3'-trailer cleavage
LRIRT_RS03590	COG0300	oxidoreductase activity
LRIRT_RS03595	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
LRIRT_RS03595	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
LRIRT_RS03650	COG4695	Portal protein
LRIRT_RS03675	COG0328	RNA-DNA hybrid ribonuclease activity
LRIRT_RS03680	COG3425	synthase
LRIRT_RS03685	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LRIRT_RS03690	COG4224	UPF0291 protein
LRIRT_RS03695	COG3763	UPF0154 protein
LRIRT_RS03700	COG0204	Acyl-transferase
LRIRT_RS03705	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
LRIRT_RS03710	COG2827	Endonuclease containing a URI domain
LRIRT_RS03715	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LRIRT_RS03720	COG0052	Belongs to the universal ribosomal protein uS2 family
LRIRT_RS03725	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
LRIRT_RS03730	COG0528	UMP kinase activity
LRIRT_RS03735	COG0233	cytoplasmic translational termination
LRIRT_RS03750	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
LRIRT_RS03755	COG4589	Belongs to the CDS family
LRIRT_RS03760	COG0750	zinc metalloprotease
LRIRT_RS03765	COG0442	prolyl-tRNA aminoacylation
LRIRT_RS03770	COG2176	DNA-directed DNA polymerase activity
LRIRT_RS03775	COG0779	Required for maturation of 30S ribosomal subunits
LRIRT_RS03780	COG0195	Participates in both transcription termination and antitermination
LRIRT_RS03785	COG2740	Nucleic-acid-binding protein implicated in transcription termination
LRIRT_RS03790	COG1358	cellular component organization or biogenesis
LRIRT_RS03795	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
LRIRT_RS03800	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
LRIRT_RS03805	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
LRIRT_RS03810	COG0196	riboflavin kinase activity
LRIRT_RS03820	COG1420	regulation of RNA biosynthetic process
LRIRT_RS03825	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
LRIRT_RS03830	COG0443	Heat shock 70 kDa protein
LRIRT_RS03835	COG0484	heat shock protein binding
LRIRT_RS03840	COG0481	GTPase activity
LRIRT_RS03845	COG4974	Belongs to the 'phage' integrase family
LRIRT_RS03880	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
LRIRT_RS03885	COG0039	L-malate dehydrogenase activity
LRIRT_RS03900	COG2264	protein methyltransferase activity
LRIRT_RS03905	COG1385	rRNA (uridine-N3-)-methyltransferase activity
LRIRT_RS03915	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LRIRT_RS03920	COG1490	D-aminoacyl-tRNA deacylase activity
LRIRT_RS03925	COG3001	Fructosamine kinase
LRIRT_RS03930	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
LRIRT_RS03940	COG1126	abc transporter atp-binding protein
LRIRT_RS03945	COG0765	amino acid transport
LRIRT_RS03950	COG0828	Belongs to the bacterial ribosomal protein bS21 family
LRIRT_RS03955	COG1610	YqeY-like protein
LRIRT_RS03960	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
LRIRT_RS03965	COG0137	argininosuccinate synthase activity
LRIRT_RS03970	COG0165	Argininosuccinate lyase
LRIRT_RS03975	COG1268	BioY protein
LRIRT_RS03980	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
LRIRT_RS03980	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
LRIRT_RS03985	COG1702	phosphate starvation-inducible protein PhoH
LRIRT_RS03990	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
LRIRT_RS03995	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
LRIRT_RS04000	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
LRIRT_RS04005	COG1381	Involved in DNA repair and RecF pathway recombination
LRIRT_RS04010	COG0752	glycyl-tRNA synthetase alpha subunit
LRIRT_RS04015	COG0751	glycine-tRNA ligase activity
LRIRT_RS04020	COG0358	DNA primase activity
LRIRT_RS04025	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LRIRT_RS04030	COG0436	Aminotransferase
LRIRT_RS04040	COG2384	SAM-dependent methyltransferase
LRIRT_RS04045	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
LRIRT_RS04050	COG2195	Cleaves the N-terminal amino acid of tripeptides
LRIRT_RS04060	COG0587	DNA-directed DNA polymerase activity
LRIRT_RS04070	COG2996	Protein conserved in bacteria
LRIRT_RS04085	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
LRIRT_RS04090	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
LRIRT_RS04095	COG1187	pseudouridine synthase activity
LRIRT_RS04100	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
LRIRT_RS04110	COG0514	ATP-dependent DNA helicase (RecQ)
LRIRT_RS04120	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
LRIRT_RS04125	COG0539	negative regulation of cytoplasmic translation
LRIRT_RS04130	COG1160	GTP binding
LRIRT_RS04135	COG0776	regulation of translation
LRIRT_RS04145	COG0617	tRNA 3'-terminal CCA addition
LRIRT_RS04150	COG0488	(ABC) transporter
LRIRT_RS04155	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
LRIRT_RS04160	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
LRIRT_RS04165	COG1272	protein, Hemolysin III
LRIRT_RS04170	COG1307	EDD domain protein, DegV family
LRIRT_RS04180	COG4698	Protein conserved in bacteria
LRIRT_RS04185	COG4479	Belongs to the UPF0346 family
LRIRT_RS04190	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
LRIRT_RS04195	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
LRIRT_RS04200	COG0758	DNA mediated transformation
LRIRT_RS04205	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LRIRT_RS04215	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
LRIRT_RS04220	COG0187	DNA topoisomerase II activity
LRIRT_RS04235	COG1227	inorganic diphosphatase activity
LRIRT_RS04260	COG1247	-acetyltransferase
LRIRT_RS04280	COG1070	Carbohydrate kinase
LRIRT_RS04285	COG1609	Transcriptional regulator
LRIRT_RS04290	COG2610	gluconate transmembrane transporter activity
LRIRT_RS04325	COG1396	sequence-specific DNA binding
LRIRT_RS04360	COG3723	Recombinational DNA repair protein, rece pathway
LRIRT_RS04525	COG5280	Phage tail tape measure protein TP901
LRIRT_RS04525	COG3953	SLT domain
LRIRT_RS04580	COG4824	toxin secretion phage lysis holin
LRIRT_RS04585	COG5263	repeat protein
LRIRT_RS04585	COG5632	N-Acetylmuramoyl-L-alanine amidase
LRIRT_RS04590	COG1070	Carbohydrate kinase
LRIRT_RS04610	COG0154	amidase activity
LRIRT_RS04625	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
LRIRT_RS04640	COG4974	Belongs to the 'phage' integrase family
LRIRT_RS04650	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
LRIRT_RS04665	COG1957	nucleoside hydrolase
LRIRT_RS04670	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LRIRT_RS04670	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LRIRT_RS04675	COG0307	riboflavin synthase, alpha
LRIRT_RS04680	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LRIRT_RS04680	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LRIRT_RS04685	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
LRIRT_RS04690	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LRIRT_RS04700	COG2271	Major facilitator Superfamily
LRIRT_RS04715	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
LRIRT_RS04720	COG0318	PFAM AMP-dependent synthetase and ligase
LRIRT_RS04735	COG0396	ATPase activity
LRIRT_RS04740	COG0719	Fe-S assembly protein
LRIRT_RS04745	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
LRIRT_RS04755	COG0719	Fe-S assembly protein
LRIRT_RS04760	COG2151	metal-sulfur cluster biosynthetic enzyme
LRIRT_RS04770	COG2197	response regulator
LRIRT_RS04780	COG0561	phosphatase activity
LRIRT_RS04785	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
LRIRT_RS04785	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LRIRT_RS04795	COG3275	phosphorelay sensor kinase activity
LRIRT_RS04810	COG1346	cytolysis
LRIRT_RS04825	COG1609	Transcriptional regulator
LRIRT_RS04860	COG1199	ATP-dependent helicase activity
LRIRT_RS04860	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LRIRT_RS04870	COG3935	DnaD domain protein
LRIRT_RS04875	COG0697	spore germination
LRIRT_RS04880	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LRIRT_RS04885	COG3331	DNA recombination
LRIRT_RS04890	COG4474	Belongs to the UPF0398 family
LRIRT_RS04895	COG3599	regulation of cell shape
LRIRT_RS04900	COG1780	Probably involved in ribonucleotide reductase function
LRIRT_RS04905	COG0116	Belongs to the methyltransferase superfamily
LRIRT_RS04910	COG0328	RNA-DNA hybrid ribonuclease activity
LRIRT_RS04925	COG0564	pseudouridine synthase activity
LRIRT_RS04930	COG0505	Belongs to the CarA family
LRIRT_RS04935	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
LRIRT_RS04940	COG1293	RNA-binding protein homologous to eukaryotic snRNP
LRIRT_RS04945	COG1307	EDD domain protein, DegV family
LRIRT_RS04955	COG1418	mRNA catabolic process
LRIRT_RS04980	COG2848	UPF0210 protein
LRIRT_RS04985	COG3830	Belongs to the UPF0237 family
LRIRT_RS04990	COG0656	L-ascorbic acid biosynthetic process
LRIRT_RS04995	COG0583	DNA-binding transcription factor activity
LRIRT_RS05010	COG2707	UPF0756 membrane protein
LRIRT_RS05015	COG2814	Major facilitator Superfamily
LRIRT_RS05025	COG1253	flavin adenine dinucleotide binding
LRIRT_RS05055	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LRIRT_RS05070	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
LRIRT_RS05080	COG1113	amino acid transport
LRIRT_RS05125	COG0561	phosphatase activity
LRIRT_RS05215	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
LRIRT_RS05230	COG0439	Biotin carboxylase
LRIRT_RS05245	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LRIRT_RS05250	COG1028	Short-chain dehydrogenase reductase Sdr
LRIRT_RS05255	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
LRIRT_RS05260	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LRIRT_RS05265	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LRIRT_RS05270	COG1846	Transcriptional regulator
LRIRT_RS05275	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LRIRT_RS05285	COG4974	Belongs to the 'phage' integrase family
LRIRT_RS05295	COG1752	Esterase of the alpha-beta hydrolase superfamily
LRIRT_RS05320	COG2181	nitrate reductase activity
LRIRT_RS05330	COG1140	nitrate reductase beta subunit
LRIRT_RS05335	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
LRIRT_RS05340	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
LRIRT_RS05375	COG2197	response regulator
LRIRT_RS05395	COG2223	nitrite transmembrane transporter activity
LRIRT_RS05415	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LRIRT_RS05420	COG1120	ATPase activity
LRIRT_RS05485	COG4372	Transposase
LRIRT_RS05500	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
LRIRT_RS05505	COG0351	phosphomethylpyrimidine kinase
LRIRT_RS05510	COG0352	thiamine-phosphate diphosphorylase activity
LRIRT_RS05580	COG0363	glucosamine-6-phosphate deaminase activity
LRIRT_RS05585	COG2184	nucleotidyltransferase activity
LRIRT_RS05595	COG0737	Belongs to the 5'-nucleotidase family
LRIRT_RS05605	COG0419	ATPase involved in DNA repair
LRIRT_RS05615	COG4464	protein tyrosine phosphatase activity
LRIRT_RS05650	COG0833	amino acid
LRIRT_RS05655	COG2040	homocysteine
LRIRT_RS05690	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
LRIRT_RS05710	COG1091	dTDP-4-dehydrorhamnose reductase activity
LRIRT_RS05725	COG1316	TRANSCRIPTIONal
LRIRT_RS05770	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
LRIRT_RS05775	COG1942	4-Oxalocrotonate Tautomerase
LRIRT_RS05780	COG0569	domain protein
LRIRT_RS05780	COG0475	glutathione-regulated potassium exporter activity
LRIRT_RS05805	COG0450	alkyl hydroperoxide reductase
LRIRT_RS05810	COG1760	l-serine dehydratase
LRIRT_RS05815	COG1760	l-serine dehydratase
LRIRT_RS05830	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
LRIRT_RS05845	COG2226	methyltransferase
LRIRT_RS05850	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
LRIRT_RS05870	COG1874	Beta-galactosidase
LRIRT_RS05875	COG2190	(PTS) system
LRIRT_RS05875	COG2211	Major facilitator Superfamily
LRIRT_RS05880	COG1609	Transcriptional regulator
LRIRT_RS05895	COG0708	Exodeoxyribonuclease III
LRIRT_RS05915	COG0335	large ribosomal subunit rRNA binding
LRIRT_RS05920	COG0531	amino acid
LRIRT_RS05925	COG0336	Belongs to the RNA methyltransferase TrmD family
LRIRT_RS05930	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
LRIRT_RS05935	COG1837	Belongs to the UPF0109 family
LRIRT_RS05940	COG0228	four-way junction DNA binding
LRIRT_RS05945	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
LRIRT_RS05950	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
LRIRT_RS05955	COG0552	protein localization to endoplasmic reticulum
LRIRT_RS05960	COG1196	nuclear chromosome segregation
LRIRT_RS05965	COG0571	ribonuclease III activity
LRIRT_RS05970	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LRIRT_RS05975	COG0416	fatty acid biosynthetic process
LRIRT_RS05980	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
LRIRT_RS05990	COG1302	Protein conserved in bacteria
LRIRT_RS05995	COG0227	Belongs to the bacterial ribosomal protein bL28 family
LRIRT_RS06000	COG1564	THIamine pyrophosphokinase
LRIRT_RS06005	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
LRIRT_RS06010	COG1162	GTPase activity
LRIRT_RS06015	COG2815	serine threonine protein kinase
LRIRT_RS06015	COG0515	serine threonine protein kinase
LRIRT_RS06020	COG0631	protein serine/threonine phosphatase activity
LRIRT_RS06025	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LRIRT_RS06025	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LRIRT_RS06030	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
LRIRT_RS06035	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
LRIRT_RS06040	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
LRIRT_RS06045	COG1758	RNA polymerase activity
LRIRT_RS06050	COG0194	GDP metabolic process
LRIRT_RS06060	COG0497	DNA recombination
LRIRT_RS06065	COG1438	arginine binding
LRIRT_RS06070	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
LRIRT_RS06080	COG1722	exodeoxyribonuclease VII activity
LRIRT_RS06085	COG1570	exodeoxyribonuclease VII activity
LRIRT_RS06090	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
LRIRT_RS06095	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LRIRT_RS06100	COG1302	Protein conserved in bacteria
LRIRT_RS06110	COG0006	proline dipeptidase activity
LRIRT_RS06115	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
LRIRT_RS06120	COG0211	Belongs to the bacterial ribosomal protein bL27 family
LRIRT_RS06130	COG0261	This protein binds to 23S rRNA in the presence of protein L20
LRIRT_RS06135	COG1309	transcriptional regulator
LRIRT_RS06160	COG2151	metal-sulfur cluster biosynthetic enzyme
LRIRT_RS06165	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LRIRT_RS06170	COG1464	Belongs to the NlpA lipoprotein family
LRIRT_RS06175	COG0436	Aminotransferase
LRIRT_RS06180	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LRIRT_RS06190	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
LRIRT_RS06200	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LRIRT_RS06205	COG1940	carbohydrate kinase activity
LRIRT_RS06215	COG0457	Tetratricopeptide repeat
LRIRT_RS06215	COG0705	Rhomboid family
LRIRT_RS06220	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
LRIRT_RS06225	COG0267	Belongs to the bacterial ribosomal protein bL33 family
LRIRT_RS06230	COG0768	penicillin binding
LRIRT_RS06245	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LRIRT_RS06250	COG0572	uridine kinase
LRIRT_RS06260	COG0072	phenylalanine-tRNA ligase activity
LRIRT_RS06260	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LRIRT_RS06265	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
LRIRT_RS06270	COG1733	regulation of RNA biosynthetic process
LRIRT_RS06280	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LRIRT_RS06285	COG1254	Belongs to the acylphosphatase family
LRIRT_RS06290	COG0706	membrane insertase activity
LRIRT_RS06295	COG0242	peptide deformylase activity
LRIRT_RS06310	COG5002	protein histidine kinase activity
LRIRT_RS06315	COG0745	RESPONSE REGULATOR receiver
LRIRT_RS06320	COG0333	Belongs to the bacterial ribosomal protein bL32 family
LRIRT_RS06330	COG1323	Belongs to the UPF0348 family
LRIRT_RS06340	COG0799	negative regulation of ribosome biogenesis
LRIRT_RS06345	COG1713	HD superfamily hydrolase involved in NAD metabolism
LRIRT_RS06350	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
LRIRT_RS06355	COG1534	Rna-binding protein
LRIRT_RS06360	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
LRIRT_RS06365	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
LRIRT_RS06370	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
LRIRT_RS06375	COG0291	Belongs to the bacterial ribosomal protein bL35 family
LRIRT_RS06380	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
LRIRT_RS06385	COG1484	DNA-dependent DNA replication
LRIRT_RS06395	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
LRIRT_RS06400	COG0237	dephospho-CoA kinase activity
LRIRT_RS06405	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LRIRT_RS06410	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LRIRT_RS06410	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LRIRT_RS06425	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LRIRT_RS06435	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LRIRT_RS06450	COG0667	Aldo Keto reductase
LRIRT_RS06455	COG0438	transferase activity, transferring glycosyl groups
LRIRT_RS06475	COG0220	tRNA (guanine-N7-)-methyltransferase activity
LRIRT_RS06480	COG4473	ABC transporter
LRIRT_RS06485	COG1131	(ABC) transporter
LRIRT_RS06490	COG0537	adenosine 5'-monophosphoramidase activity
LRIRT_RS06505	COG4717	serine-type aminopeptidase activity
LRIRT_RS06510	COG0420	3'-5' exonuclease activity
LRIRT_RS06515	COG3679	Belongs to the UPF0342 family
LRIRT_RS06520	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LRIRT_RS06525	COG0018	arginyl-trna synthetase
LRIRT_RS06530	COG0351	phosphomethylpyrimidine kinase
LRIRT_RS06535	COG0039	L-malate dehydrogenase activity
LRIRT_RS06555	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
LRIRT_RS06560	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
LRIRT_RS06565	COG0285	dihydrofolate synthase activity
LRIRT_RS06570	COG0302	gtp cyclohydrolase
LRIRT_RS06575	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
LRIRT_RS06575	COG0302	gtp cyclohydrolase
LRIRT_RS06580	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
LRIRT_RS06625	COG1428	Deoxynucleoside kinase
LRIRT_RS06630	COG1388	LysM domain
LRIRT_RS06630	COG1705	Flagellar rod assembly protein muramidase FlgJ
LRIRT_RS06635	COG0589	response to stress
LRIRT_RS06640	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LRIRT_RS06645	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
LRIRT_RS06650	COG2244	polysaccharide biosynthetic process
LRIRT_RS06660	COG0495	leucyl-tRNA aminoacylation
LRIRT_RS06665	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
LRIRT_RS06670	COG2818	Glycosylase
LRIRT_RS06680	COG2814	Major facilitator Superfamily
LRIRT_RS06690	COG1113	amino acid transport
LRIRT_RS06710	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LRIRT_RS06715	COG0071	Belongs to the small heat shock protein (HSP20) family
LRIRT_RS06720	COG0656	L-ascorbic acid biosynthetic process
LRIRT_RS06725	COG0167	dihydroorotate dehydrogenase activity
LRIRT_RS06725	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
LRIRT_RS06730	COG0493	'glutamate synthase
LRIRT_RS06735	COG0708	Exodeoxyribonuclease III
LRIRT_RS06760	COG0602	queuosine metabolic process
LRIRT_RS06770	COG0477	Major facilitator Superfamily
LRIRT_RS06860	COG0438	transferase activity, transferring glycosyl groups
LRIRT_RS06865	COG0438	transferase activity, transferring glycosyl groups
LRIRT_RS06870	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LRIRT_RS06875	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LRIRT_RS06885	COG0542	response to heat
LRIRT_RS06905	COG1131	(ABC) transporter
LRIRT_RS06910	COG1725	Transcriptional regulator
LRIRT_RS06915	COG3867	Arabinogalactan endo-beta-1,4-galactanase
LRIRT_RS06920	COG3867	Arabinogalactan endo-beta-1,4-galactanase
LRIRT_RS06975	COG0366	Alpha amylase catalytic
LRIRT_RS06975	COG5263	repeat protein
LRIRT_RS06980	COG0791	NLP P60 protein
LRIRT_RS06980	COG3883	PFAM NLP P60 protein
LRIRT_RS06995	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
LRIRT_RS07000	COG1316	TRANSCRIPTIONal
LRIRT_RS07010	COG0628	permease
LRIRT_RS07040	COG1216	Glycosyl transferase, family 2
LRIRT_RS07040	COG1442	glycosyl transferase family 8
LRIRT_RS07055	COG5632	N-Acetylmuramoyl-L-alanine amidase
LRIRT_RS07055	COG3266	domain, Protein
LRIRT_RS07055	COG4193	domain, Protein
LRIRT_RS07065	COG1705	Flagellar rod assembly protein muramidase FlgJ
LRIRT_RS07075	COG0438	transferase activity, transferring glycosyl groups
LRIRT_RS07080	COG0438	transferase activity, transferring glycosyl groups
LRIRT_RS07100	COG0562	UDP-galactopyranose mutase
LRIRT_RS07110	COG0463	Glycosyl transferase, family 2
LRIRT_RS07120	COG2137	regulation of response to DNA damage stimulus
LRIRT_RS07135	COG1295	ribonuclease BN
LRIRT_RS07150	COG0436	Aminotransferase
LRIRT_RS07155	COG0024	Methionine aminopeptidase
LRIRT_RS07160	COG0716	FMN binding
LRIRT_RS07165	COG2246	polysaccharide biosynthetic process
LRIRT_RS07175	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
LRIRT_RS07190	COG0673	inositol 2-dehydrogenase activity
LRIRT_RS07210	COG2918	glutathione biosynthetic process
LRIRT_RS07210	COG1181	Belongs to the D-alanine--D-alanine ligase family
LRIRT_RS07235	COG0454	-acetyltransferase
LRIRT_RS07265	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LRIRT_RS07280	COG0456	acetyltransferase
LRIRT_RS07290	COG0004	ammonium transporteR
LRIRT_RS07320	COG1131	(ABC) transporter
LRIRT_RS07340	COG3012	SEC-C Motif Domain Protein
LRIRT_RS07355	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LRIRT_RS07390	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
LRIRT_RS07400	COG4974	Belongs to the 'phage' integrase family
LRIRT_RS07410	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
LRIRT_RS07420	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LRIRT_RS07425	COG1597	lipid kinase activity
LRIRT_RS07430	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LRIRT_RS07435	COG0154	amidase activity
LRIRT_RS07440	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LRIRT_RS07445	COG4851	CamS sex pheromone cAM373 precursor
LRIRT_RS07450	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
LRIRT_RS07465	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LRIRT_RS07470	COG1705	Flagellar rod assembly protein muramidase FlgJ
LRIRT_RS07480	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
LRIRT_RS07485	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
LRIRT_RS07490	COG0101	tRNA pseudouridine synthase activity
LRIRT_RS07510	COG0203	ribosomal protein L17
LRIRT_RS07515	COG0202	RNA polymerase activity
LRIRT_RS07520	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
LRIRT_RS07525	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
LRIRT_RS07530	COG0257	Belongs to the bacterial ribosomal protein bL36 family
LRIRT_RS07535	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
LRIRT_RS07550	COG0200	Binds to the 23S rRNA
LRIRT_RS07555	COG1841	ribosomal large subunit assembly
LRIRT_RS07560	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
LRIRT_RS07565	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
LRIRT_RS07570	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
LRIRT_RS07575	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
LRIRT_RS07580	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
LRIRT_RS07585	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
LRIRT_RS07590	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
LRIRT_RS07595	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
LRIRT_RS07605	COG0255	Belongs to the universal ribosomal protein uL29 family
LRIRT_RS07610	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
LRIRT_RS07615	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
LRIRT_RS07620	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
LRIRT_RS07625	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
LRIRT_RS07630	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
LRIRT_RS07635	COG0089	rRNA binding
LRIRT_RS07640	COG0088	Forms part of the polypeptide exit tunnel
LRIRT_RS07645	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
LRIRT_RS07650	COG0051	transcription antitermination factor activity, RNA binding
LRIRT_RS07660	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
LRIRT_RS07665	COG0049	tRNA binding
LRIRT_RS07670	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
LRIRT_RS07685	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
LRIRT_RS07690	COG0085	RNA polymerase activity
LRIRT_RS07700	COG0542	response to heat
LRIRT_RS07705	COG4463	regulation of RNA biosynthetic process
LRIRT_RS07710	COG1064	alcohol dehydrogenase
LRIRT_RS07745	COG1428	Deoxynucleoside kinase
LRIRT_RS07755	COG0833	amino acid
LRIRT_RS07780	COG1278	Cold shock
LRIRT_RS07815	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LRIRT_RS07820	COG0765	amino acid transport
LRIRT_RS07825	COG0765	amino acid transport
LRIRT_RS07850	COG2814	Major facilitator Superfamily
LRIRT_RS07860	COG0564	pseudouridine synthase activity
LRIRT_RS07870	COG0392	lysyltransferase activity
LRIRT_RS07870	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
LRIRT_RS07875	COG0693	protein deglycase activity
LRIRT_RS07885	COG2814	Major facilitator Superfamily
LRIRT_RS07900	COG0583	DNA-binding transcription factor activity
LRIRT_RS07905	COG0471	metal ion transport
LRIRT_RS07915	COG0114	fumarate hydratase activity
LRIRT_RS07920	COG0281	malic enzyme
LRIRT_RS07925	COG0583	DNA-binding transcription factor activity
LRIRT_RS07955	COG2017	converts alpha-aldose to the beta-anomer
LRIRT_RS07965	COG1686	Belongs to the peptidase S11 family
LRIRT_RS07985	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LRIRT_RS07990	COG1288	antiporter activity
LRIRT_RS08020	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
LRIRT_RS08025	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
LRIRT_RS08030	COG1914	H( )-stimulated, divalent metal cation uptake system
LRIRT_RS08035	COG2226	methyltransferase
LRIRT_RS08040	COG0569	domain protein
LRIRT_RS08045	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
LRIRT_RS08055	COG0778	Nitroreductase
LRIRT_RS08065	COG1215	transferase activity, transferring glycosyl groups
LRIRT_RS08075	COG0704	Plays a role in the regulation of phosphate uptake
LRIRT_RS08080	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
LRIRT_RS08085	COG0581	inorganic phosphate transmembrane transporter activity
LRIRT_RS08090	COG0573	inorganic phosphate transmembrane transporter activity
LRIRT_RS08095	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
LRIRT_RS08100	COG0745	RESPONSE REGULATOR receiver
LRIRT_RS08130	COG1482	cell wall glycoprotein biosynthetic process
LRIRT_RS08135	COG1482	cell wall glycoprotein biosynthetic process
LRIRT_RS08140	COG0583	DNA-binding transcription factor activity
LRIRT_RS08150	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LRIRT_RS08160	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
LRIRT_RS08175	COG1464	Belongs to the NlpA lipoprotein family
LRIRT_RS08180	COG1854	S-ribosylhomocysteine lyase activity
LRIRT_RS08195	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
LRIRT_RS08205	COG2801	Transposase and inactivated derivatives
LRIRT_RS08255	COG2814	Major facilitator Superfamily
LRIRT_RS08260	COG4475	Protein of unknown function (DUF436)
LRIRT_RS08275	COG2223	nitrite transmembrane transporter activity
LRIRT_RS08280	COG4974	Belongs to the 'phage' integrase family
LRIRT_RS08320	COG1002	Type II restriction enzyme, methylase subunits
LRIRT_RS08330	COG0519	Catalyzes the synthesis of GMP from XMP
LRIRT_RS08340	COG1072	(Pantothenic acid kinase))
LRIRT_RS08345	COG1368	sulfuric ester hydrolase activity
LRIRT_RS08355	COG0446	pyridine nucleotide-disulphide oxidoreductase
LRIRT_RS08370	COG3973	AAA domain
LRIRT_RS08375	COG0586	Pfam SNARE associated Golgi protein
LRIRT_RS08385	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
LRIRT_RS08390	COG2261	transglycosylase associated protein
LRIRT_RS08400	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LRIRT_RS08405	COG1511	domain protein
LRIRT_RS08430	COG0735	belongs to the Fur family
LRIRT_RS08435	COG0194	GDP metabolic process
LRIRT_RS08440	COG2816	NAD+ diphosphatase activity
LRIRT_RS08445	COG0531	amino acid
LRIRT_RS08450	COG0477	Major facilitator Superfamily
LRIRT_RS08465	COG1177	transmembrane transport
LRIRT_RS08475	COG3842	ATPase activity
LRIRT_RS08480	COG2936	dipeptidyl-peptidase activity
LRIRT_RS08485	COG2267	carboxylic ester hydrolase activity
LRIRT_RS08495	COG0783	Belongs to the Dps family
LRIRT_RS08530	COG0492	ferredoxin-NADP+ reductase activity
LRIRT_RS08555	COG1122	ATPase activity
LRIRT_RS08575	COG3759	membrane
LRIRT_RS08585	COG1396	sequence-specific DNA binding
LRIRT_RS08595	COG3321	synthase
LRIRT_RS08595	COG0604	alcohol dehydrogenase
LRIRT_RS08600	COG3775	system Galactitol-specific IIC component
LRIRT_RS08605	COG2814	Major facilitator Superfamily
LRIRT_RS08610	COG1131	(ABC) transporter
LRIRT_RS08630	COG0095	Lipoate-protein ligase
LRIRT_RS08635	COG0589	response to stress
LRIRT_RS08645	COG1940	carbohydrate kinase activity
LRIRT_RS08650	COG1114	Component of the transport system for branched-chain amino acids
LRIRT_RS08660	COG0675	Transposase, IS605 OrfB family
LRIRT_RS08680	COG2188	Transcriptional regulator
LRIRT_RS08685	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
LRIRT_RS08705	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LRIRT_RS08720	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
LRIRT_RS08735	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
LRIRT_RS08740	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
LRIRT_RS08745	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
LRIRT_RS08750	COG0113	porphobilinogen synthase activity
LRIRT_RS08755	COG0181	hydroxymethylbilane synthase activity
LRIRT_RS08760	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
LRIRT_RS08770	COG1492	cobalamin metabolic process
LRIRT_RS08775	COG1122	ATPase activity
LRIRT_RS08785	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
LRIRT_RS08790	COG0310	cobalt ion transport
LRIRT_RS08805	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LRIRT_RS08805	COG1587	Uroporphyrinogen-III synthase
LRIRT_RS08840	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
LRIRT_RS08855	COG1797	cobyrinic acid a,c-diamide synthase activity
LRIRT_RS08860	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LRIRT_RS08870	COG2096	Adenosyltransferase
LRIRT_RS08875	COG0431	NADPH-dependent FMN reductase
LRIRT_RS08880	COG0716	FMN binding
LRIRT_RS08895	COG0588	phosphoglycerate mutase activity
LRIRT_RS08900	COG2365	Tyrosine phosphatase family
LRIRT_RS08910	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
LRIRT_RS08935	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
LRIRT_RS08945	COG4869	propanediol catabolic process
LRIRT_RS09000	COG0849	cell division
LRIRT_RS09005	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
LRIRT_RS09020	COG0628	permease
LRIRT_RS09030	COG1846	Transcriptional regulator
LRIRT_RS09050	COG1253	flavin adenine dinucleotide binding
LRIRT_RS09065	COG2807	transmembrane transport
LRIRT_RS09075	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
LRIRT_RS09085	COG2190	(PTS) system
LRIRT_RS09085	COG2211	Major facilitator Superfamily
LRIRT_RS09105	COG0586	Pfam SNARE associated Golgi protein
LRIRT_RS09115	COG1609	Transcriptional regulator
LRIRT_RS09120	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
LRIRT_RS09125	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
LRIRT_RS09135	COG2365	Tyrosine phosphatase family
LRIRT_RS09140	COG1881	PFAM PEBP family protein
LRIRT_RS09160	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LRIRT_RS09170	COG0656	L-ascorbic acid biosynthetic process
LRIRT_RS09175	COG0745	RESPONSE REGULATOR receiver
LRIRT_RS09180	COG2205	protein histidine kinase activity
LRIRT_RS09185	COG1136	(ABC) transporter
LRIRT_RS09200	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
LRIRT_RS09205	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LRIRT_RS09210	COG2814	Major facilitator Superfamily
LRIRT_RS09215	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
LRIRT_RS09220	COG3620	sequence-specific DNA binding
LRIRT_RS09225	COG3590	peptidase
LRIRT_RS09245	COG2094	Belongs to the DNA glycosylase MPG family
LRIRT_RS09250	COG3189	MarR family transcriptional regulator
LRIRT_RS09255	COG2249	NAD(P)H dehydrogenase (quinone) activity
LRIRT_RS09280	COG2404	hydrolase activity, acting on ester bonds
LRIRT_RS09290	COG1114	Component of the transport system for branched-chain amino acids
LRIRT_RS09305	COG0488	(ABC) transporter
LRIRT_RS09345	COG4120	Belongs to the binding-protein-dependent transport system permease family
LRIRT_RS09360	COG0640	Transcriptional regulator
LRIRT_RS09365	COG0534	Mate efflux family protein
LRIRT_RS09370	COG3118	belongs to the thioredoxin family
LRIRT_RS09375	COG0861	Integral membrane protein TerC family
LRIRT_RS09380	COG0564	pseudouridine synthase activity
LRIRT_RS09400	COG1757	Na H antiporter
LRIRT_RS09405	COG0124	histidyl-tRNA synthetase
LRIRT_RS09430	COG1288	antiporter activity
LRIRT_RS09435	COG0588	phosphoglycerate mutase activity
LRIRT_RS09445	COG1368	sulfuric ester hydrolase activity
LRIRT_RS09460	COG1686	Belongs to the peptidase S11 family
LRIRT_RS09475	COG1376	ErfK ybiS ycfS ynhG family protein
LRIRT_RS09485	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
LRIRT_RS09495	COG0124	histidyl-tRNA synthetase
LRIRT_RS09500	COG2814	Major facilitator Superfamily
LRIRT_RS09515	COG1609	Transcriptional regulator
LRIRT_RS09520	COG1705	Flagellar rod assembly protein muramidase FlgJ
LRIRT_RS09520	COG1388	LysM domain
LRIRT_RS09525	COG0640	Transcriptional regulator
LRIRT_RS09535	COG1136	(ABC) transporter
LRIRT_RS09535	COG0577	efflux transmembrane transporter activity
LRIRT_RS09540	COG1136	(ABC) transporter
LRIRT_RS09560	COG1914	H( )-stimulated, divalent metal cation uptake system
LRIRT_RS09570	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
LRIRT_RS09585	COG0531	amino acid
LRIRT_RS09590	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
LRIRT_RS09605	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
LRIRT_RS09625	COG2153	protein acetylation
LRIRT_RS09635	COG1733	regulation of RNA biosynthetic process
LRIRT_RS09645	COG1733	regulation of RNA biosynthetic process
LRIRT_RS09660	COG3579	cysteine-type endopeptidase activity
LRIRT_RS09670	COG0308	aminopeptidase N
LRIRT_RS09675	COG4720	Psort location CytoplasmicMembrane, score
LRIRT_RS09680	COG2502	aspartate--ammonia ligase
LRIRT_RS09685	COG0017	Asparaginyl-tRNA synthetase
LRIRT_RS09695	COG3706	GGDEF domain
LRIRT_RS09705	COG1215	transferase activity, transferring glycosyl groups
LRIRT_RS09730	COG2910	NAD(P)H-binding
LRIRT_RS09745	COG0656	L-ascorbic acid biosynthetic process
LRIRT_RS09750	COG0583	DNA-binding transcription factor activity
LRIRT_RS09755	COG0252	asparaginase activity
LRIRT_RS09765	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LRIRT_RS09790	COG0583	DNA-binding transcription factor activity
LRIRT_RS09800	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LRIRT_RS09810	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
LRIRT_RS09865	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LRIRT_RS09870	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
LRIRT_RS09875	COG1285	pathogenesis
LRIRT_RS09890	COG1687	branched-chain amino acid
LRIRT_RS09895	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
LRIRT_RS09900	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LRIRT_RS09930	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
LRIRT_RS09935	COG0367	asparagine synthase
LRIRT_RS09940	COG0445	tRNA wobble uridine modification
LRIRT_RS09945	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
LRIRT_RS09955	COG0706	membrane insertase activity
LRIRT_RS09960	COG0594	ribonuclease P activity
LRIRT_RS09965	COG0230	Belongs to the bacterial ribosomal protein bL34 family
LRIRT_RS10015	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
LRIRT_RS10225	COG2801	Transposase and inactivated derivatives