locus-tag	class	description
AYR52_RS00005	COG3404	Formiminotransferase-cyclodeaminase
AYR52_RS00015	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AYR52_RS00020	COG0248	Ppx GppA phosphatase
AYR52_RS00020	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AYR52_RS00025	COG1126	abc transporter atp-binding protein
AYR52_RS00030	COG0765	amino acid transport
AYR52_RS00035	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AYR52_RS00070	COG0454	-acetyltransferase
AYR52_RS00075	COG1114	Component of the transport system for branched-chain amino acids
AYR52_RS00080	COG0697	spore germination
AYR52_RS00100	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AYR52_RS00130	COG0561	phosphatase activity
AYR52_RS00150	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AYR52_RS00150	COG0512	Glutamine amidotransferase of anthranilate synthase
AYR52_RS00175	COG0159	tryptophan synthase activity
AYR52_RS00180	COG0398	Pfam SNARE associated Golgi protein
AYR52_RS00190	COG0626	cystathionine gamma-synthase activity
AYR52_RS00210	COG3328	transposase activity
AYR52_RS00220	COG3118	belongs to the thioredoxin family
AYR52_RS00230	COG0745	RESPONSE REGULATOR receiver
AYR52_RS00235	COG5002	protein histidine kinase activity
AYR52_RS00250	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AYR52_RS00255	COG1696	Membrane protein involved in D-alanine export
AYR52_RS00260	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AYR52_RS00265	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
AYR52_RS00275	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AYR52_RS00285	COG3328	transposase activity
AYR52_RS00290	COG0586	Pfam SNARE associated Golgi protein
AYR52_RS00340	COG0791	NLP P60 protein
AYR52_RS00360	COG1074	ATP-dependent DNA helicase activity
AYR52_RS00385	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AYR52_RS00405	COG4932	domain protein
AYR52_RS00405	COG4886	Leucine-rich repeat (LRR) protein
AYR52_RS00410	COG0765	amino acid transport
AYR52_RS00420	COG2213	PTS system mannitol-specific
AYR52_RS00425	COG3711	transcriptional antiterminator
AYR52_RS00430	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AYR52_RS00440	COG0745	RESPONSE REGULATOR receiver
AYR52_RS00450	COG1686	Belongs to the peptidase S11 family
AYR52_RS00455	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AYR52_RS00465	COG1794	racemase activity, acting on amino acids and derivatives
AYR52_RS00475	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AYR52_RS00495	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
AYR52_RS00510	COG0628	permease
AYR52_RS00515	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AYR52_RS00525	COG0588	phosphoglycerate mutase activity
AYR52_RS00540	COG1309	transcriptional regulator
AYR52_RS00565	COG1309	transcriptional regulator
AYR52_RS00570	COG4372	Transposase
AYR52_RS00595	COG1882	Formate acetyltransferase
AYR52_RS00600	COG1349	DNA-binding transcription factor activity
AYR52_RS00605	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AYR52_RS00660	COG0477	Major facilitator Superfamily
AYR52_RS00665	COG1131	(ABC) transporter
AYR52_RS00675	COG1309	transcriptional regulator
AYR52_RS00700	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AYR52_RS00720	COG0789	Transcriptional regulator
AYR52_RS00725	COG1902	pentaerythritol trinitrate reductase activity
AYR52_RS00735	COG0583	DNA-binding transcription factor activity
AYR52_RS00740	COG0281	malic enzyme
AYR52_RS00755	COG1136	(ABC) transporter
AYR52_RS00760	COG0577	efflux transmembrane transporter activity
AYR52_RS00785	COG2233	PERMEase
AYR52_RS00800	COG4221	oxidoreductase activity
AYR52_RS00815	COG0789	Transcriptional regulator
AYR52_RS00825	COG1335	isochorismatase
AYR52_RS00835	COG1937	Protein conserved in bacteria
AYR52_RS00840	COG0546	phosphoglycolate phosphatase activity
AYR52_RS00855	COG0702	epimerase
AYR52_RS00865	COG4372	Transposase
AYR52_RS00885	COG0860	N-Acetylmuramoyl-L-alanine amidase
AYR52_RS00890	COG5002	protein histidine kinase activity
AYR52_RS00900	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
AYR52_RS00905	COG0463	Glycosyl transferase, family 2
AYR52_RS00915	COG4585	Histidine kinase
AYR52_RS00920	COG2197	response regulator
AYR52_RS00940	COG0024	Methionine aminopeptidase
AYR52_RS00975	COG1216	Glycosyl transferase, family 2
AYR52_RS01000	COG0438	transferase activity, transferring glycosyl groups
AYR52_RS01005	COG2368	4-hydroxyphenylacetate
AYR52_RS01010	COG0516	GMP reductase activity
AYR52_RS01020	COG1058	Belongs to the CinA family
AYR52_RS01020	COG1546	Belongs to the CinA family
AYR52_RS01050	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AYR52_RS01055	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AYR52_RS01060	COG0148	phosphopyruvate hydratase activity
AYR52_RS01065	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AYR52_RS01090	COG0735	belongs to the Fur family
AYR52_RS01105	COG0436	Aminotransferase
AYR52_RS01110	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AYR52_RS01120	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AYR52_RS01125	COG0765	amino acid transport
AYR52_RS01130	COG0765	amino acid transport
AYR52_RS01140	COG0531	amino acid
AYR52_RS01145	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
AYR52_RS01150	COG0531	amino acid
AYR52_RS01160	COG0039	L-malate dehydrogenase activity
AYR52_RS01165	COG0193	aminoacyl-tRNA hydrolase activity
AYR52_RS01170	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AYR52_RS01175	COG2244	polysaccharide biosynthetic process
AYR52_RS01180	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AYR52_RS01190	COG1098	S1 RNA binding domain
AYR52_RS01195	COG0037	tRNA processing
AYR52_RS01210	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AYR52_RS01215	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AYR52_RS01220	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AYR52_RS01250	COG3104	oligopeptide transport
AYR52_RS01270	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AYR52_RS01275	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AYR52_RS01280	COG2188	Transcriptional regulator
AYR52_RS01285	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
AYR52_RS01290	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
AYR52_RS01300	COG1091	dTDP-4-dehydrorhamnose reductase activity
AYR52_RS01310	COG0463	Glycosyl transferase, family 2
AYR52_RS01330	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
AYR52_RS01335	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AYR52_RS01355	COG4120	Belongs to the binding-protein-dependent transport system permease family
AYR52_RS01360	COG1122	ATPase activity
AYR52_RS01365	COG2183	response to ionizing radiation
AYR52_RS01370	COG3091	SprT-like family
AYR52_RS01375	COG0460	homoserine dehydrogenase
AYR52_RS01390	COG3933	PFAM sigma-54 factor interaction domain-containing protein
AYR52_RS01390	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
AYR52_RS01400	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AYR52_RS01400	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
AYR52_RS01410	COG3715	PTS system
AYR52_RS01415	COG3716	PTS system mannose fructose sorbose family IID component
AYR52_RS01435	COG4372	Transposase
AYR52_RS01455	COG0025	NhaP-type Na H and K H
AYR52_RS01460	COG1271	oxidase subunit
AYR52_RS01465	COG1294	oxidase, subunit
AYR52_RS01470	COG4988	ABC transporter
AYR52_RS01475	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
AYR52_RS01485	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AYR52_RS01490	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AYR52_RS01500	COG3944	biosynthesis protein
AYR52_RS01505	COG0489	protein tyrosine kinase activity
AYR52_RS01510	COG4464	protein tyrosine phosphatase activity
AYR52_RS01520	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AYR52_RS01535	COG0114	fumarate hydratase activity
AYR52_RS01540	COG0531	amino acid
AYR52_RS01545	COG0028	Belongs to the TPP enzyme family
AYR52_RS01550	COG1304	FMN binding
AYR52_RS01555	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AYR52_RS01565	COG0439	Biotin carboxylase
AYR52_RS01575	COG0825	malonyl-CoA metabolic process
AYR52_RS01580	COG1316	TRANSCRIPTIONal
AYR52_RS01600	COG0588	phosphoglycerate mutase activity
AYR52_RS01620	COG0756	dUTP diphosphatase activity
AYR52_RS01625	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AYR52_RS01630	COG4956	integral membrane protein (PIN domain superfamily)
AYR52_RS01645	COG0215	cysteine-tRNA ligase activity
AYR52_RS01650	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
AYR52_RS01655	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AYR52_RS01660	COG3688	RNA-binding protein containing a PIN domain
AYR52_RS01670	COG0142	geranyltranstransferase activity
AYR52_RS01705	COG0250	Participates in transcription elongation, termination and antitermination
AYR52_RS01720	COG0081	regulation of translation
AYR52_RS01725	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AYR52_RS01740	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
AYR52_RS01740	COG0392	lysyltransferase activity
AYR52_RS01755	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AYR52_RS01760	COG1393	Belongs to the ArsC family
AYR52_RS01765	COG2813	Specifically methylates the guanine in position
AYR52_RS01775	COG0656	L-ascorbic acid biosynthetic process
AYR52_RS01780	COG0590	tRNA wobble adenosine to inosine editing
AYR52_RS01785	COG1285	pathogenesis
AYR52_RS01800	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AYR52_RS01810	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AYR52_RS01820	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AYR52_RS01825	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AYR52_RS01830	COG3870	Protein conserved in bacteria
AYR52_RS01840	COG1774	PSP1 C-terminal conserved region
AYR52_RS01900	COG0564	pseudouridine synthase activity
AYR52_RS01920	COG1316	TRANSCRIPTIONal
AYR52_RS01930	COG0305	Participates in initiation and elongation during chromosome replication
AYR52_RS01985	COG3475	LICD family
AYR52_RS01995	COG0562	UDP-galactopyranose mutase
AYR52_RS02000	COG2244	polysaccharide biosynthetic process
AYR52_RS02005	COG0438	transferase activity, transferring glycosyl groups
AYR52_RS02015	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AYR52_RS02045	COG0463	Glycosyl transferase, family 2
AYR52_RS02050	COG0463	Glycosyl transferase, family 2
AYR52_RS02075	COG3883	PFAM NLP P60 protein
AYR52_RS02075	COG0791	NLP P60 protein
AYR52_RS02085	COG2246	polysaccharide biosynthetic process
AYR52_RS02095	COG1368	sulfuric ester hydrolase activity
AYR52_RS02130	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AYR52_RS02150	COG1214	PFAM Peptidase M22, glycoprotease
AYR52_RS02165	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AYR52_RS02170	COG0488	(ABC) transporter
AYR52_RS02175	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
AYR52_RS02180	COG1266	CAAX protease self-immunity
AYR52_RS02185	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AYR52_RS02190	COG0459	protein refolding
AYR52_RS02195	COG0531	amino acid
AYR52_RS02200	COG1692	metallophosphoesterase
AYR52_RS02205	COG4550	Control of competence regulator ComK, YlbF/YmcA
AYR52_RS02210	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AYR52_RS02215	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AYR52_RS02225	COG2076	Multidrug Resistance protein
AYR52_RS02230	COG0632	four-way junction helicase activity
AYR52_RS02235	COG2255	four-way junction helicase activity
AYR52_RS02240	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AYR52_RS02245	COG0343	queuine tRNA-ribosyltransferase activity
AYR52_RS02250	COG1862	Preprotein translocase
AYR52_RS02255	COG1012	belongs to the aldehyde dehydrogenase family
AYR52_RS02255	COG1454	alcohol dehydrogenase
AYR52_RS02260	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AYR52_RS02265	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AYR52_RS02275	COG4109	DRTGG domain
AYR52_RS02280	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AYR52_RS02285	COG0513	Belongs to the DEAD box helicase family
AYR52_RS02290	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AYR52_RS02320	COG1193	negative regulation of DNA recombination
AYR52_RS02325	COG3118	belongs to the thioredoxin family
AYR52_RS02330	COG0322	excinuclease ABC activity
AYR52_RS02335	COG1719	4-vinyl reductase, 4VR
AYR52_RS02345	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AYR52_RS02355	COG2171	N-acyltransferase activity
AYR52_RS02360	COG1473	amidohydrolase
AYR52_RS02375	COG0302	gtp cyclohydrolase
AYR52_RS02375	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AYR52_RS02380	COG0302	gtp cyclohydrolase
AYR52_RS02390	COG1854	S-ribosylhomocysteine lyase activity
AYR52_RS02410	COG1316	TRANSCRIPTIONal
AYR52_RS02415	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
AYR52_RS02420	COG2873	o-acetylhomoserine
AYR52_RS02430	COG0656	L-ascorbic acid biosynthetic process
AYR52_RS02440	COG0668	transmembrane transport
AYR52_RS02465	COG1609	Transcriptional regulator
AYR52_RS02470	COG3328	transposase activity
AYR52_RS02475	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AYR52_RS02480	COG1011	Hydrolase
AYR52_RS02490	COG1268	BioY protein
AYR52_RS02495	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
AYR52_RS02495	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
AYR52_RS02525	COG1418	mRNA catabolic process
AYR52_RS02530	COG0640	Transcriptional regulator
AYR52_RS02545	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AYR52_RS02555	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AYR52_RS02600	COG0737	Belongs to the 5'-nucleotidase family
AYR52_RS02605	COG4470	Protein conserved in bacteria
AYR52_RS02610	COG0647	UMP catabolic process
AYR52_RS02625	COG0586	Pfam SNARE associated Golgi protein
AYR52_RS02630	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AYR52_RS02635	COG0492	ferredoxin-NADP+ reductase activity
AYR52_RS02645	COG1098	S1 RNA binding domain
AYR52_RS02785	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AYR52_RS02790	COG0477	Major facilitator Superfamily
AYR52_RS02795	COG0671	phosphoesterase, PA-phosphatase related
AYR52_RS02800	COG0495	leucyl-tRNA aminoacylation
AYR52_RS02805	COG2244	polysaccharide biosynthetic process
AYR52_RS02810	COG1187	pseudouridine synthase activity
AYR52_RS02815	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AYR52_RS02840	COG0018	arginyl-trna synthetase
AYR52_RS02845	COG1438	arginine binding
AYR52_RS02850	COG0564	pseudouridine synthase activity
AYR52_RS02855	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AYR52_RS02860	COG3679	Belongs to the UPF0342 family
AYR52_RS02865	COG0420	3'-5' exonuclease activity
AYR52_RS02870	COG4717	serine-type aminopeptidase activity
AYR52_RS02875	COG3481	metal-dependent phosphohydrolase, HD sub domain
AYR52_RS02900	COG0537	adenosine 5'-monophosphoramidase activity
AYR52_RS02905	COG1131	(ABC) transporter
AYR52_RS02915	COG0510	thiamine kinase activity
AYR52_RS02920	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AYR52_RS02930	COG0589	response to stress
AYR52_RS02935	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AYR52_RS02945	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AYR52_RS02950	COG0670	Belongs to the BI1 family
AYR52_RS02955	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AYR52_RS02955	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AYR52_RS02965	COG0237	dephospho-CoA kinase activity
AYR52_RS02970	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AYR52_RS02975	COG3611	Membrane attachment protein
AYR52_RS02980	COG1484	DNA-dependent DNA replication
AYR52_RS02985	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AYR52_RS02990	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AYR52_RS03000	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AYR52_RS03010	COG0604	alcohol dehydrogenase
AYR52_RS03015	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
AYR52_RS03020	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
AYR52_RS03030	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AYR52_RS03035	COG1713	HD superfamily hydrolase involved in NAD metabolism
AYR52_RS03040	COG0799	negative regulation of ribosome biogenesis
AYR52_RS03045	COG2226	methyltransferase
AYR52_RS03050	COG1323	Belongs to the UPF0348 family
AYR52_RS03065	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
AYR52_RS03070	COG0745	RESPONSE REGULATOR receiver
AYR52_RS03075	COG5002	protein histidine kinase activity
AYR52_RS03080	COG0706	membrane insertase activity
AYR52_RS03085	COG1254	Belongs to the acylphosphatase family
AYR52_RS03090	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AYR52_RS03100	COG1733	regulation of RNA biosynthetic process
AYR52_RS03105	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AYR52_RS03110	COG0072	phenylalanine-tRNA ligase activity
AYR52_RS03115	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AYR52_RS03120	COG0572	uridine kinase
AYR52_RS03125	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AYR52_RS03135	COG4585	Histidine kinase
AYR52_RS03140	COG2197	response regulator
AYR52_RS03145	COG4485	Bacterial membrane protein, YfhO
AYR52_RS03150	COG0768	penicillin binding
AYR52_RS03165	COG0419	ATPase involved in DNA repair
AYR52_RS03170	COG1376	ErfK ybiS ycfS ynhG family protein
AYR52_RS03175	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AYR52_RS03180	COG0705	Rhomboid family
AYR52_RS03180	COG0457	Tetratricopeptide repeat
AYR52_RS03190	COG1940	carbohydrate kinase activity
AYR52_RS03195	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AYR52_RS03200	COG0584	glycerophosphoryl diester phosphodiesterase
AYR52_RS03205	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AYR52_RS03210	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
AYR52_RS03215	COG0789	Transcriptional regulator
AYR52_RS03220	COG0174	glutamine synthetase
AYR52_RS03225	COG4372	Transposase
AYR52_RS03245	COG2936	dipeptidyl-peptidase activity
AYR52_RS03255	COG1012	belongs to the aldehyde dehydrogenase family
AYR52_RS03300	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AYR52_RS03310	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AYR52_RS03315	COG0006	proline dipeptidase activity
AYR52_RS03320	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AYR52_RS03325	COG1302	Protein conserved in bacteria
AYR52_RS03330	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AYR52_RS03335	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AYR52_RS03340	COG1570	exodeoxyribonuclease VII activity
AYR52_RS03345	COG1722	exodeoxyribonuclease VII activity
AYR52_RS03355	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
AYR52_RS03360	COG1438	arginine binding
AYR52_RS03365	COG0497	DNA recombination
AYR52_RS03380	COG0194	GDP metabolic process
AYR52_RS03390	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AYR52_RS03395	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AYR52_RS03400	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AYR52_RS03405	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AYR52_RS03405	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AYR52_RS03415	COG2815	serine threonine protein kinase
AYR52_RS03415	COG0515	serine threonine protein kinase
AYR52_RS03420	COG1162	GTPase activity
AYR52_RS03425	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AYR52_RS03435	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AYR52_RS03445	COG1302	Protein conserved in bacteria
AYR52_RS03450	COG1461	Dihydroxyacetone kinase
AYR52_RS03455	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AYR52_RS03460	COG0416	fatty acid biosynthetic process
AYR52_RS03465	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AYR52_RS03470	COG0571	ribonuclease III activity
AYR52_RS03475	COG1196	nuclear chromosome segregation
AYR52_RS03480	COG0561	phosphatase activity
AYR52_RS03485	COG0552	protein localization to endoplasmic reticulum
AYR52_RS03490	COG4372	Transposase
AYR52_RS03510	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
AYR52_RS03515	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AYR52_RS03555	COG0110	maltose O-acetyltransferase activity
AYR52_RS03565	COG1063	alcohol dehydrogenase
AYR52_RS03575	COG0228	four-way junction DNA binding
AYR52_RS03580	COG1837	Belongs to the UPF0109 family
AYR52_RS03585	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AYR52_RS03600	COG0335	large ribosomal subunit rRNA binding
AYR52_RS03610	COG0737	Belongs to the 5'-nucleotidase family
AYR52_RS03635	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AYR52_RS03640	COG1942	4-Oxalocrotonate Tautomerase
AYR52_RS03645	COG0019	diaminopimelate decarboxylase activity
AYR52_RS03660	COG1028	Short-chain dehydrogenase reductase Sdr
AYR52_RS03675	COG0477	Major facilitator Superfamily
AYR52_RS03700	COG2814	Major facilitator Superfamily
AYR52_RS03715	COG0789	Transcriptional regulator
AYR52_RS03720	COG0656	L-ascorbic acid biosynthetic process
AYR52_RS03735	COG1088	dTDP-glucose 4,6-dehydratase activity
AYR52_RS03765	COG4115	mRNA cleavage
AYR52_RS03775	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AYR52_RS03780	COG0110	maltose O-acetyltransferase activity
AYR52_RS03785	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AYR52_RS03790	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AYR52_RS03815	COG3022	response to hydroperoxide
AYR52_RS03820	COG0305	Participates in initiation and elongation during chromosome replication
AYR52_RS03840	COG0778	Nitroreductase
AYR52_RS03855	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
AYR52_RS03910	COG1053	succinate dehydrogenase
AYR52_RS03915	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AYR52_RS03920	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AYR52_RS03925	COG0617	tRNA 3'-terminal CCA addition
AYR52_RS03930	COG0488	(ABC) transporter
AYR52_RS03935	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AYR52_RS03945	COG1272	protein, Hemolysin III
AYR52_RS03950	COG1307	EDD domain protein, DegV family
AYR52_RS03955	COG2755	lipolytic protein G-D-S-L family
AYR52_RS03960	COG4698	Protein conserved in bacteria
AYR52_RS03965	COG4479	Belongs to the UPF0346 family
AYR52_RS03970	COG0793	Belongs to the peptidase S41A family
AYR52_RS03970	COG3409	Peptidoglycan-binding domain 1 protein
AYR52_RS03975	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AYR52_RS03975	COG0574	Belongs to the PEP-utilizing enzyme family
AYR52_RS03985	COG0300	oxidoreductase activity
AYR52_RS03990	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
AYR52_RS03995	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AYR52_RS04000	COG0758	DNA mediated transformation
AYR52_RS04005	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AYR52_RS04010	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
AYR52_RS04020	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
AYR52_RS04025	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
AYR52_RS04040	COG0187	DNA topoisomerase II activity
AYR52_RS04055	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AYR52_RS04065	COG0583	DNA-binding transcription factor activity
AYR52_RS04070	COG1227	inorganic diphosphatase activity
AYR52_RS04080	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AYR52_RS04085	COG0372	Belongs to the citrate synthase family
AYR52_RS04095	COG1307	EDD domain protein, DegV family
AYR52_RS04100	COG1293	RNA-binding protein homologous to eukaryotic snRNP
AYR52_RS04120	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AYR52_RS04125	COG0284	orotidine-5'-phosphate decarboxylase activity
AYR52_RS04130	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AYR52_RS04135	COG0505	Belongs to the CarA family
AYR52_RS04140	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AYR52_RS04145	COG0540	Belongs to the ATCase OTCase family
AYR52_RS04150	COG2233	PERMEase
AYR52_RS04155	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
AYR52_RS04160	COG0564	pseudouridine synthase activity
AYR52_RS04165	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AYR52_RS04170	COG1573	uracil-dna glycosylase
AYR52_RS04175	COG2759	Belongs to the formate--tetrahydrofolate ligase family
AYR52_RS04180	COG1278	Cold shock
AYR52_RS04190	COG0328	RNA-DNA hybrid ribonuclease activity
AYR52_RS04215	COG0116	Belongs to the methyltransferase superfamily
AYR52_RS04225	COG3599	regulation of cell shape
AYR52_RS04230	COG4474	Belongs to the UPF0398 family
AYR52_RS04235	COG3331	DNA recombination
AYR52_RS04240	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AYR52_RS04245	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AYR52_RS04255	COG0017	Asparaginyl-tRNA synthetase
AYR52_RS04270	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AYR52_RS04270	COG1199	ATP-dependent helicase activity
AYR52_RS04275	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
AYR52_RS04290	COG1304	FMN binding
AYR52_RS04310	COG2151	metal-sulfur cluster biosynthetic enzyme
AYR52_RS04315	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AYR52_RS04320	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AYR52_RS04330	COG1131	(ABC) transporter
AYR52_RS04335	COG2188	Transcriptional regulator
AYR52_RS04350	COG1301	dicarboxylic acid transport
AYR52_RS04420	COG4221	oxidoreductase activity
AYR52_RS04420	COG3321	synthase
AYR52_RS04420	COG0604	alcohol dehydrogenase
AYR52_RS04420	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AYR52_RS04440	COG0655	NAD(P)H dehydrogenase (quinone) activity
AYR52_RS04450	COG0596	Alpha beta hydrolase
AYR52_RS04455	COG2814	Major facilitator Superfamily
AYR52_RS04460	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
AYR52_RS04470	COG0457	Tetratricopeptide repeat
AYR52_RS04485	COG0539	negative regulation of cytoplasmic translation
AYR52_RS04490	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AYR52_RS04500	COG0514	ATP-dependent DNA helicase (RecQ)
AYR52_RS04515	COG1187	pseudouridine synthase activity
AYR52_RS04520	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AYR52_RS04525	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AYR52_RS04540	COG0735	belongs to the Fur family
AYR52_RS04545	COG2996	Protein conserved in bacteria
AYR52_RS04550	COG2707	UPF0756 membrane protein
AYR52_RS04565	COG0587	DNA-directed DNA polymerase activity
AYR52_RS04575	COG0542	response to heat
AYR52_RS04585	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AYR52_RS04595	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AYR52_RS04600	COG0358	DNA primase activity
AYR52_RS04605	COG0751	glycine-tRNA ligase activity
AYR52_RS04610	COG0752	glycyl-tRNA synthetase alpha subunit
AYR52_RS04615	COG1381	Involved in DNA repair and RecF pathway recombination
AYR52_RS04625	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AYR52_RS04630	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AYR52_RS04635	COG1702	phosphate starvation-inducible protein PhoH
AYR52_RS04650	COG1610	YqeY-like protein
AYR52_RS04655	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AYR52_RS04665	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
AYR52_RS04670	COG0778	Nitroreductase
AYR52_RS04675	COG1114	Component of the transport system for branched-chain amino acids
AYR52_RS04680	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AYR52_RS04690	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AYR52_RS04710	COG4372	Transposase
AYR52_RS04715	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AYR52_RS04720	COG0124	histidyl-tRNA synthetase
AYR52_RS04725	COG4991	sh3 domain protein
AYR52_RS04725	COG0860	N-Acetylmuramoyl-L-alanine amidase
AYR52_RS04725	COG3103	Sh3 type 3 domain protein
AYR52_RS04740	COG0546	phosphoglycolate phosphatase activity
AYR52_RS04745	COG1490	D-aminoacyl-tRNA deacylase activity
AYR52_RS04750	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AYR52_RS04760	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AYR52_RS04765	COG2264	protein methyltransferase activity
AYR52_RS04775	COG2094	Belongs to the DNA glycosylase MPG family
AYR52_RS04815	COG0564	pseudouridine synthase activity
AYR52_RS04820	COG1705	Flagellar rod assembly protein muramidase FlgJ
AYR52_RS04820	COG1388	LysM domain
AYR52_RS04845	COG0481	GTPase activity
AYR52_RS04850	COG0484	heat shock protein binding
AYR52_RS04855	COG0443	Heat shock 70 kDa protein
AYR52_RS04860	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AYR52_RS04880	COG4372	Transposase
AYR52_RS04885	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AYR52_RS04890	COG0196	riboflavin kinase activity
AYR52_RS04895	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AYR52_RS04900	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AYR52_RS04915	COG2740	Nucleic-acid-binding protein implicated in transcription termination
AYR52_RS04920	COG0195	Participates in both transcription termination and antitermination
AYR52_RS04925	COG0779	Required for maturation of 30S ribosomal subunits
AYR52_RS04930	COG2176	DNA-directed DNA polymerase activity
AYR52_RS04935	COG0442	prolyl-tRNA aminoacylation
AYR52_RS04945	COG0750	zinc metalloprotease
AYR52_RS04950	COG4589	Belongs to the CDS family
AYR52_RS04955	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AYR52_RS04975	COG0052	Belongs to the universal ribosomal protein uS2 family
AYR52_RS04985	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AYR52_RS04990	COG2827	Endonuclease containing a URI domain
AYR52_RS04995	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
AYR52_RS05000	COG0204	Acyl-transferase
AYR52_RS05005	COG3763	UPF0154 protein
AYR52_RS05010	COG4224	UPF0291 protein
AYR52_RS05015	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AYR52_RS05050	COG3425	synthase
AYR52_RS05065	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AYR52_RS05065	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
AYR52_RS05070	COG5416	Lipopolysaccharide assembly protein A domain
AYR52_RS05075	COG0300	oxidoreductase activity
AYR52_RS05080	COG1234	tRNA 3'-trailer cleavage
AYR52_RS05085	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AYR52_RS05085	COG2755	lipolytic protein G-D-S-L family
AYR52_RS05090	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AYR52_RS05095	COG1349	DNA-binding transcription factor activity
AYR52_RS05100	COG1105	Belongs to the carbohydrate kinase PfkB family
AYR52_RS05105	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AYR52_RS05105	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AYR52_RS05105	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AYR52_RS05115	COG0322	excinuclease ABC activity
AYR52_RS05120	COG1126	abc transporter atp-binding protein
AYR52_RS05125	COG0765	amino acid transport
AYR52_RS05145	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AYR52_RS05155	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AYR52_RS05160	COG0544	peptidyl-prolyl cis-trans isomerase activity
AYR52_RS05185	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AYR52_RS05190	COG0268	Binds directly to 16S ribosomal RNA
AYR52_RS05195	COG1466	dna polymerase III delta subunit
AYR52_RS05200	COG2333	competence protein COMEC
AYR52_RS05200	COG0658	competence protein
AYR52_RS05205	COG2131	deaminase
AYR52_RS05210	COG1555	photosystem II stabilization
AYR52_RS05210	COG1596	polysaccharide export
AYR52_RS05220	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AYR52_RS05225	COG0742	ribosomal rna small subunit methyltransferase
AYR52_RS05230	COG4471	UPF0298 protein
AYR52_RS05240	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
AYR52_RS05245	COG0772	Belongs to the SEDS family
AYR52_RS05250	COG4838	Belongs to the UPF0358 family
AYR52_RS05260	COG1217	gtp-binding protein TYPA
AYR52_RS05265	COG0483	inositol monophosphate 1-phosphatase activity
AYR52_RS05270	COG4476	Belongs to the UPF0223 family
AYR52_RS05280	COG0242	peptide deformylase activity
AYR52_RS05300	COG1597	lipid kinase activity
AYR52_RS05305	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AYR52_RS05315	COG0406	alpha-ribazole phosphatase activity
AYR52_RS05320	COG0482	sulfurtransferase activity
AYR52_RS05330	COG1104	cysteine desulfurase activity
AYR52_RS05335	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AYR52_RS05345	COG0494	nUDIX hydrolase
AYR52_RS05355	COG3853	Toxic anion resistance protein (TelA)
AYR52_RS05360	COG2814	Major facilitator Superfamily
AYR52_RS05365	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AYR52_RS05370	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AYR52_RS05375	COG3599	regulation of cell shape
AYR52_RS05380	COG2302	S4 RNA-binding domain
AYR52_RS05390	COG1799	cell septum assembly
AYR52_RS05395	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AYR52_RS05400	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AYR52_RS05410	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AYR52_RS05415	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AYR52_RS05420	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AYR52_RS05430	COG0768	penicillin binding
AYR52_RS05440	COG0275	rRNA processing
AYR52_RS05445	COG2001	Belongs to the MraZ family
AYR52_RS05465	COG0527	aspartate kinase activity
AYR52_RS05470	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AYR52_RS05475	COG1126	abc transporter atp-binding protein
AYR52_RS05480	COG0765	amino acid transport
AYR52_RS05485	COG2894	cell division
AYR52_RS05490	COG0850	regulation of cytokinetic process
AYR52_RS05500	COG1792	Involved in formation and maintenance of cell shape
AYR52_RS05505	COG1077	Cell shape determining protein MreB Mrl
AYR52_RS05510	COG1278	Cold shock
AYR52_RS05515	COG2003	Belongs to the UPF0758 family
AYR52_RS05520	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AYR52_RS05530	COG0525	valine-tRNA ligase activity
AYR52_RS05535	COG0301	tRNA thio-modification
AYR52_RS05540	COG1104	cysteine desulfurase activity
AYR52_RS05545	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
AYR52_RS05550	COG1956	GAF domain-containing protein
AYR52_RS05555	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AYR52_RS05565	COG4493	Belongs to the UPF0637 family
AYR52_RS05575	COG2918	glutathione biosynthetic process
AYR52_RS05575	COG1181	Belongs to the D-alanine--D-alanine ligase family
AYR52_RS05580	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AYR52_RS05595	COG0589	response to stress
AYR52_RS05600	COG2326	polyphosphate kinase activity
AYR52_RS05610	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AYR52_RS05620	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AYR52_RS05625	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AYR52_RS05630	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AYR52_RS05635	COG1881	PFAM PEBP family protein
AYR52_RS05640	COG1605	Chorismate mutase
AYR52_RS05640	COG0077	Prephenate dehydratase
AYR52_RS05645	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AYR52_RS05650	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
AYR52_RS05650	COG1605	Chorismate mutase
AYR52_RS05655	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AYR52_RS05660	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AYR52_RS05670	COG4372	Transposase
AYR52_RS05715	COG3942	CHAP domain
AYR52_RS05715	COG1388	LysM domain
AYR52_RS05940	COG0629	single-stranded DNA binding
AYR52_RS05960	COG0305	Participates in initiation and elongation during chromosome replication
AYR52_RS05965	COG1846	Transcriptional regulator
AYR52_RS06005	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AYR52_RS06030	COG0719	Fe-S assembly protein
AYR52_RS06040	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AYR52_RS06045	COG0719	Fe-S assembly protein
AYR52_RS06055	COG1464	Belongs to the NlpA lipoprotein family
AYR52_RS06060	COG2011	ABC-type metal ion transport system permease component
AYR52_RS06065	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AYR52_RS06070	COG0772	Belongs to the SEDS family
AYR52_RS06090	COG1077	Cell shape determining protein MreB Mrl
AYR52_RS06095	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AYR52_RS06105	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AYR52_RS06110	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AYR52_RS06125	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AYR52_RS06130	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AYR52_RS06140	COG0356	it plays a direct role in the translocation of protons across the membrane
AYR52_RS06150	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AYR52_RS06160	COG0009	L-threonylcarbamoyladenylate synthase
AYR52_RS06165	COG2890	protein-(glutamine-N5) methyltransferase activity
AYR52_RS06170	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AYR52_RS06175	COG1435	thymidine kinase activity
AYR52_RS06180	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AYR52_RS06185	COG1482	cell wall glycoprotein biosynthetic process
AYR52_RS06190	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AYR52_RS06225	COG1278	Cold shock
AYR52_RS06230	COG1428	Deoxynucleoside kinase
AYR52_RS06260	COG0166	Belongs to the GPI family
AYR52_RS06265	COG4975	Glucose uptake
AYR52_RS06275	COG1368	sulfuric ester hydrolase activity
AYR52_RS06290	COG4372	Transposase
AYR52_RS06305	COG5002	protein histidine kinase activity
AYR52_RS06305	COG3850	Histidine kinase
AYR52_RS06310	COG0745	RESPONSE REGULATOR receiver
AYR52_RS06315	COG0561	phosphatase activity
AYR52_RS06410	COG1113	amino acid transport
AYR52_RS06420	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AYR52_RS06425	COG0827	DNA restriction-modification system
AYR52_RS06450	COG4537	Required for transformation and DNA binding
AYR52_RS06455	COG1459	type II secretion system
AYR52_RS06460	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AYR52_RS06475	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AYR52_RS06480	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AYR52_RS06500	COG1177	transmembrane transport
AYR52_RS06505	COG1176	ABC-type spermidine putrescine transport system, permease component I
AYR52_RS06510	COG3842	ATPase activity
AYR52_RS06515	COG0604	alcohol dehydrogenase
AYR52_RS06525	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AYR52_RS06530	COG0708	Exodeoxyribonuclease III
AYR52_RS06535	COG2176	DNA-directed DNA polymerase activity
AYR52_RS06540	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AYR52_RS06545	COG0802	atpase or kinase
AYR52_RS06550	COG0280	phosphate acetyltransferase
AYR52_RS06555	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AYR52_RS06560	COG0561	phosphatase activity
AYR52_RS06575	COG0765	amino acid transport
AYR52_RS06580	COG1126	abc transporter atp-binding protein
AYR52_RS06590	COG0557	exoribonuclease II activity
AYR52_RS06595	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AYR52_RS06605	COG0126	phosphoglycerate kinase activity
AYR52_RS06620	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
AYR52_RS06630	COG0740	serine-type endopeptidase activity
AYR52_RS06635	COG1481	regulation of sporulation
AYR52_RS06640	COG0391	Required for morphogenesis under gluconeogenic growth conditions
AYR52_RS06645	COG1660	Displays ATPase and GTPase activities
AYR52_RS06655	COG0165	Argininosuccinate lyase
AYR52_RS06660	COG0137	argininosuccinate synthase activity
AYR52_RS06665	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AYR52_RS06680	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AYR52_RS06690	COG0492	ferredoxin-NADP+ reductase activity
AYR52_RS06700	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AYR52_RS06705	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AYR52_RS06715	COG1950	PFAM Membrane protein of
AYR52_RS06725	COG1983	PspC domain protein
AYR52_RS06735	COG0704	Plays a role in the regulation of phosphate uptake
AYR52_RS06740	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AYR52_RS06745	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AYR52_RS06750	COG0581	inorganic phosphate transmembrane transporter activity
AYR52_RS06755	COG0573	inorganic phosphate transmembrane transporter activity
AYR52_RS06765	COG5002	protein histidine kinase activity
AYR52_RS06770	COG0745	RESPONSE REGULATOR receiver
AYR52_RS06785	COG0653	protein targeting
AYR52_RS06795	COG1040	competence protein
AYR52_RS06800	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
AYR52_RS06805	COG1739	Uncharacterized protein family UPF0029
AYR52_RS06810	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AYR52_RS06815	COG1418	mRNA catabolic process
AYR52_RS06820	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AYR52_RS06825	COG1546	Belongs to the CinA family
AYR52_RS06825	COG1058	Belongs to the CinA family
AYR52_RS06830	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AYR52_RS06835	COG1426	Protein conserved in bacteria
AYR52_RS06840	COG0300	oxidoreductase activity
AYR52_RS06845	COG0612	Peptidase, M16
AYR52_RS06850	COG0612	Peptidase, M16
AYR52_RS06855	COG1674	ftsk spoiiie
AYR52_RS06900	COG1388	LysM domain
AYR52_RS06900	COG3942	CHAP domain
AYR52_RS06950	COG3953	SLT domain
AYR52_RS06950	COG5280	Phage tail tape measure protein TP901
AYR52_RS07100	COG0513	Belongs to the DEAD box helicase family
AYR52_RS07125	COG1396	sequence-specific DNA binding
AYR52_RS07150	COG0516	GMP reductase activity
AYR52_RS07155	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AYR52_RS07160	COG0628	permease
AYR52_RS07170	COG2706	6-phosphogluconolactonase activity
AYR52_RS07175	COG3142	Participates in the control of copper homeostasis
AYR52_RS07180	COG2239	Acts as a magnesium transporter
AYR52_RS07185	COG0564	pseudouridine synthase activity
AYR52_RS07190	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AYR52_RS07195	COG2357	RelA SpoT domain protein
AYR52_RS07220	COG4862	establishment of competence for transformation
AYR52_RS07225	COG1393	Belongs to the ArsC family
AYR52_RS07230	COG1234	tRNA 3'-trailer cleavage
AYR52_RS07320	COG1368	sulfuric ester hydrolase activity
AYR52_RS07325	COG4703	Protein of unknown function (DUF1797)
AYR52_RS07335	COG0438	transferase activity, transferring glycosyl groups
AYR52_RS07340	COG0438	transferase activity, transferring glycosyl groups
AYR52_RS07360	COG0542	response to heat
AYR52_RS07380	COG1253	flavin adenine dinucleotide binding
AYR52_RS07385	COG0628	permease
AYR52_RS07395	COG3557	Belongs to the UPF0374 family
AYR52_RS07400	COG2137	regulation of response to DNA damage stimulus
AYR52_RS07405	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AYR52_RS07410	COG1012	belongs to the aldehyde dehydrogenase family
AYR52_RS07415	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AYR52_RS07425	COG0716	FMN binding
AYR52_RS07430	COG0463	Glycosyl transferase, family 2
AYR52_RS07450	COG0513	Belongs to the DEAD box helicase family
AYR52_RS07455	COG0673	inositol 2-dehydrogenase activity
AYR52_RS07465	COG3757	hydrolase, family 25
AYR52_RS07465	COG3409	Peptidoglycan-binding domain 1 protein
AYR52_RS07470	COG0531	amino acid
AYR52_RS07475	COG2252	PERMEase
AYR52_RS07485	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AYR52_RS07490	COG4372	Transposase
AYR52_RS07505	COG1597	lipid kinase activity
AYR52_RS07510	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AYR52_RS07515	COG0154	amidase activity
AYR52_RS07520	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AYR52_RS07530	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AYR52_RS07540	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AYR52_RS07545	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AYR52_RS07550	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AYR52_RS07555	COG1705	Flagellar rod assembly protein muramidase FlgJ
AYR52_RS07560	COG4129	membrane
AYR52_RS07585	COG1122	ATPase activity
AYR52_RS07590	COG1122	ATPase activity
AYR52_RS07595	COG0203	ribosomal protein L17
AYR52_RS07605	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AYR52_RS07610	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AYR52_RS07620	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AYR52_RS07625	COG0563	adenylate kinase activity
AYR52_RS07640	COG1841	ribosomal large subunit assembly
AYR52_RS07645	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AYR52_RS07655	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AYR52_RS07665	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AYR52_RS07670	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AYR52_RS07675	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AYR52_RS07685	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AYR52_RS07690	COG0255	Belongs to the universal ribosomal protein uL29 family
AYR52_RS07695	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AYR52_RS07700	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AYR52_RS07705	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AYR52_RS07715	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AYR52_RS07720	COG0089	rRNA binding
AYR52_RS07725	COG0088	Forms part of the polypeptide exit tunnel
AYR52_RS07730	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AYR52_RS07745	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AYR52_RS07755	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AYR52_RS07760	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
AYR52_RS07775	COG0826	peptidase U32
AYR52_RS07780	COG0826	peptidase U32
AYR52_RS07785	COG0542	response to heat
AYR52_RS07790	COG4463	regulation of RNA biosynthetic process
AYR52_RS07870	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AYR52_RS07875	COG1428	Deoxynucleoside kinase
AYR52_RS07885	COG0833	amino acid
AYR52_RS07895	COG3527	Alpha-acetolactate decarboxylase
AYR52_RS07900	COG0028	Belongs to the TPP enzyme family
AYR52_RS07905	COG1959	2 iron, 2 sulfur cluster binding
AYR52_RS07935	COG0514	ATP-dependent DNA helicase (RecQ)
AYR52_RS07940	COG1694	Mazg nucleotide pyrophosphohydrolase
AYR52_RS07950	COG2188	Transcriptional regulator
AYR52_RS07955	COG1131	(ABC) transporter
AYR52_RS07990	COG0308	aminopeptidase N
AYR52_RS07995	COG0604	alcohol dehydrogenase
AYR52_RS08005	COG1063	alcohol dehydrogenase
AYR52_RS08010	COG0477	Major facilitator Superfamily
AYR52_RS08015	COG0640	Transcriptional regulator
AYR52_RS08030	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
AYR52_RS08035	COG0477	Major facilitator Superfamily
AYR52_RS08045	COG0583	DNA-binding transcription factor activity
AYR52_RS08050	COG2936	dipeptidyl-peptidase activity
AYR52_RS08070	COG0745	RESPONSE REGULATOR receiver
AYR52_RS08075	COG1309	transcriptional regulator
AYR52_RS08080	COG1131	(ABC) transporter
AYR52_RS08100	COG3655	Transcriptional regulator
AYR52_RS08145	COG2226	methyltransferase
AYR52_RS08150	COG0519	Catalyzes the synthesis of GMP from XMP
AYR52_RS08150	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AYR52_RS08170	COG1307	EDD domain protein, DegV family
AYR52_RS08175	COG3973	AAA domain
AYR52_RS08180	COG0586	Pfam SNARE associated Golgi protein
AYR52_RS08185	COG0569	domain protein
AYR52_RS08185	COG0475	glutathione-regulated potassium exporter activity
AYR52_RS08205	COG2267	carboxylic ester hydrolase activity
AYR52_RS08210	COG0588	phosphoglycerate mutase activity
AYR52_RS08215	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
AYR52_RS08220	COG0517	IMP dehydrogenase activity
AYR52_RS08225	COG0574	Belongs to the PEP-utilizing enzyme family
AYR52_RS08225	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AYR52_RS08230	COG4122	O-methyltransferase activity
AYR52_RS08240	COG2337	Toxic component of a toxin-antitoxin (TA) module
AYR52_RS08250	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AYR52_RS08270	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AYR52_RS08275	COG1181	Belongs to the D-alanine--D-alanine ligase family
AYR52_RS08290	COG0501	Belongs to the peptidase M48B family
AYR52_RS08295	COG1704	LemA family
AYR52_RS08300	COG2814	Major facilitator Superfamily
AYR52_RS08305	COG0254	rRNA binding
AYR52_RS08310	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AYR52_RS08315	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AYR52_RS08325	COG0504	CTP synthase activity
AYR52_RS08330	COG3343	RNA polymerase activity
AYR52_RS08340	COG1078	dGTPase activity
AYR52_RS08355	COG1970	mechanosensitive ion channel activity
AYR52_RS08365	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AYR52_RS08380	COG2814	Major facilitator Superfamily
AYR52_RS08390	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AYR52_RS08395	COG4466	Protein conserved in bacteria
AYR52_RS08410	COG0084	hydrolase, TatD family'
AYR52_RS08415	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AYR52_RS08415	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AYR52_RS08420	COG0519	Catalyzes the synthesis of GMP from XMP
AYR52_RS08425	COG1801	Protein of unknown function DUF72
AYR52_RS08440	COG1051	belongs to the nudix hydrolase family
AYR52_RS08450	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AYR52_RS08485	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AYR52_RS08510	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AYR52_RS08515	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AYR52_RS08520	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AYR52_RS08525	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AYR52_RS08530	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AYR52_RS08535	COG0505	Belongs to the CarA family
AYR52_RS08540	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AYR52_RS08555	COG4475	Protein of unknown function (DUF436)
AYR52_RS08570	COG0702	epimerase
AYR52_RS08575	COG0697	spore germination
AYR52_RS08580	COG0531	amino acid
AYR52_RS08585	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
AYR52_RS08590	COG2188	Transcriptional regulator
AYR52_RS08625	COG1983	PspC domain protein
AYR52_RS08630	COG0028	Belongs to the TPP enzyme family
AYR52_RS08635	COG0300	oxidoreductase activity
AYR52_RS08650	COG1028	Short-chain dehydrogenase reductase Sdr
AYR52_RS08655	COG3189	MarR family transcriptional regulator
AYR52_RS08670	COG2365	Tyrosine phosphatase family
AYR52_RS08685	COG1253	flavin adenine dinucleotide binding
AYR52_RS08695	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AYR52_RS08700	COG1757	Na H antiporter
AYR52_RS08705	COG2814	Major facilitator Superfamily
AYR52_RS08740	COG3590	peptidase
AYR52_RS08775	COG0561	phosphatase activity
AYR52_RS08790	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AYR52_RS08795	COG0765	amino acid transport
AYR52_RS08800	COG0765	amino acid transport
AYR52_RS08805	COG1126	abc transporter atp-binding protein
AYR52_RS08815	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AYR52_RS08820	COG0393	Putative heavy-metal-binding
AYR52_RS08835	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AYR52_RS08845	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AYR52_RS08865	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
AYR52_RS08870	COG1461	Dihydroxyacetone kinase
AYR52_RS08875	COG2376	Dihydroxyacetone kinase
AYR52_RS08895	COG0765	amino acid transport
AYR52_RS08900	COG0765	amino acid transport
AYR52_RS08905	COG1126	abc transporter atp-binding protein
AYR52_RS08910	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AYR52_RS08920	COG1757	Na H antiporter
AYR52_RS08930	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
AYR52_RS08935	COG0446	pyridine nucleotide-disulphide oxidoreductase
AYR52_RS08955	COG0367	asparagine synthase
AYR52_RS08970	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AYR52_RS08975	COG1230	cation diffusion facilitator family transporter
AYR52_RS08980	COG1227	inorganic diphosphatase activity
AYR52_RS08985	COG0038	chloride channel
AYR52_RS09020	COG1278	Cold shock
AYR52_RS09030	COG0656	L-ascorbic acid biosynthetic process
AYR52_RS09040	COG0277	FAD linked oxidase domain protein
AYR52_RS09045	COG0167	dihydroorotate dehydrogenase activity
AYR52_RS09070	COG0436	Aminotransferase
AYR52_RS09075	COG0702	epimerase
AYR52_RS09085	COG1914	H( )-stimulated, divalent metal cation uptake system
AYR52_RS09090	COG0561	phosphatase activity
AYR52_RS09095	COG1136	(ABC) transporter
AYR52_RS09100	COG0577	efflux transmembrane transporter activity
AYR52_RS09105	COG3850	Histidine kinase
AYR52_RS09105	COG5002	protein histidine kinase activity
AYR52_RS09125	COG2217	Heavy metal translocating P-type atpase
AYR52_RS09135	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AYR52_RS09150	COG0438	transferase activity, transferring glycosyl groups
AYR52_RS09155	COG0438	transferase activity, transferring glycosyl groups
AYR52_RS09165	COG2084	Dehydrogenase
AYR52_RS09175	COG4221	oxidoreductase activity
AYR52_RS09180	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AYR52_RS09185	COG0561	phosphatase activity
AYR52_RS09190	COG1120	ATPase activity
AYR52_RS09200	COG0277	FAD linked oxidase domain protein
AYR52_RS09205	COG0488	(ABC) transporter
AYR52_RS09210	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AYR52_RS09230	COG1914	H( )-stimulated, divalent metal cation uptake system
AYR52_RS09235	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
AYR52_RS09240	COG4336	lyase activity
AYR52_RS09245	COG0439	Biotin carboxylase
AYR52_RS09255	COG1984	allophanate hydrolase subunit 2
AYR52_RS09260	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
AYR52_RS09270	COG2814	Major facilitator Superfamily
AYR52_RS09295	COG1827	regulation of RNA biosynthetic process
AYR52_RS09310	COG0656	L-ascorbic acid biosynthetic process
AYR52_RS09345	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AYR52_RS09350	COG1120	ATPase activity
AYR52_RS09360	COG0693	protein deglycase activity
AYR52_RS09365	COG2271	Major facilitator Superfamily
AYR52_RS09375	COG0656	L-ascorbic acid biosynthetic process
AYR52_RS09385	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AYR52_RS09400	COG1194	a g-specific adenine glycosylase
AYR52_RS09410	COG4708	membrane
AYR52_RS09425	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AYR52_RS09435	COG0012	GTP binding
AYR52_RS09440	COG4481	Protein conserved in bacteria
AYR52_RS09445	COG1475	DNA binding
AYR52_RS09450	COG1192	Involved in chromosome partitioning
AYR52_RS09470	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AYR52_RS09475	COG0604	alcohol dehydrogenase
AYR52_RS09480	COG1733	regulation of RNA biosynthetic process
AYR52_RS09485	COG1136	(ABC) transporter
AYR52_RS09485	COG0577	efflux transmembrane transporter activity
AYR52_RS09500	COG0538	isocitrate dehydrogenase activity
AYR52_RS09505	COG2365	Tyrosine phosphatase family
AYR52_RS09510	COG2918	glutathione biosynthetic process
AYR52_RS09510	COG1181	Belongs to the D-alanine--D-alanine ligase family
AYR52_RS09525	COG2252	PERMEase
AYR52_RS09535	COG0024	Methionine aminopeptidase
AYR52_RS09560	COG1668	transmembrane transport
AYR52_RS09565	COG4152	abc transporter atp-binding protein
AYR52_RS09575	COG0519	Catalyzes the synthesis of GMP from XMP
AYR52_RS09580	COG0446	pyridine nucleotide-disulphide oxidoreductase
AYR52_RS09600	COG2271	Major facilitator Superfamily
AYR52_RS09605	COG0066	3-isopropylmalate dehydratase activity
AYR52_RS09610	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AYR52_RS09615	COG0473	3-isopropylmalate dehydrogenase activity
AYR52_RS09635	COG0463	Glycosyl transferase, family 2
AYR52_RS09635	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
AYR52_RS09640	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
AYR52_RS09645	COG1393	Belongs to the ArsC family
AYR52_RS09655	COG2814	Major facilitator Superfamily
AYR52_RS09660	COG2217	Heavy metal translocating P-type atpase
AYR52_RS09665	COG0406	alpha-ribazole phosphatase activity
AYR52_RS09700	COG0438	transferase activity, transferring glycosyl groups
AYR52_RS09705	COG0463	Glycosyl transferase, family 2
AYR52_RS09715	COG1737	Transcriptional regulator
AYR52_RS09735	COG1705	Flagellar rod assembly protein muramidase FlgJ
AYR52_RS09735	COG1388	LysM domain
AYR52_RS09750	COG1442	glycosyl transferase family 8
AYR52_RS09765	COG1307	EDD domain protein, DegV family
AYR52_RS09780	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AYR52_RS09785	COG2011	ABC-type metal ion transport system permease component
AYR52_RS09790	COG1473	amidohydrolase
AYR52_RS09795	COG2873	o-acetylhomoserine
AYR52_RS09825	COG2249	NAD(P)H dehydrogenase (quinone) activity
AYR52_RS09830	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AYR52_RS09840	COG1113	amino acid transport
AYR52_RS09845	COG1511	domain protein
AYR52_RS09865	COG2807	transmembrane transport
AYR52_RS09870	COG1132	(ABC) transporter
AYR52_RS09885	COG0477	Major facilitator Superfamily
AYR52_RS09890	COG2814	Major facilitator Superfamily
AYR52_RS09895	COG0583	DNA-binding transcription factor activity
AYR52_RS09900	COG3976	FMN-binding domain protein
AYR52_RS09900	COG0431	NADPH-dependent FMN reductase
AYR52_RS09900	COG1053	succinate dehydrogenase
AYR52_RS09910	COG1393	Belongs to the ArsC family
AYR52_RS09915	COG2207	Transcriptional regulator
AYR52_RS09925	COG3732	PTS system glucitol sorbitol-specific
AYR52_RS09930	COG3730	PTS system glucitol sorbitol-specific
AYR52_RS09950	COG1045	serine acetyltransferase
AYR52_RS09955	COG0626	cystathionine gamma-synthase activity
AYR52_RS09965	COG1606	tRNA processing
AYR52_RS09970	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AYR52_RS09975	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
AYR52_RS09980	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
AYR52_RS09985	COG1691	(AIR) carboxylase
AYR52_RS09990	COG3875	lactate racemase activity
AYR52_RS09995	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AYR52_RS10000	COG0310	cobalt ion transport
AYR52_RS10005	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
AYR52_RS10010	COG1122	ATPase activity
AYR52_RS10035	COG2814	Major facilitator Superfamily
AYR52_RS10040	COG0765	amino acid transport
AYR52_RS10060	COG2814	Major facilitator Superfamily
AYR52_RS10065	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AYR52_RS10065	COG1328	CTP reductase activity
AYR52_RS10070	COG0602	queuosine metabolic process
AYR52_RS10080	COG4876	unkown
AYR52_RS10090	COG0789	Transcriptional regulator
AYR52_RS10095	COG1573	uracil-dna glycosylase
AYR52_RS10100	COG0477	Major facilitator Superfamily
AYR52_RS10110	COG0778	Nitroreductase
AYR52_RS10115	COG0300	oxidoreductase activity
AYR52_RS10130	COG0300	oxidoreductase activity
AYR52_RS10140	COG4989	oxidoreductase activity
AYR52_RS10170	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AYR52_RS10180	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
AYR52_RS10195	COG5002	protein histidine kinase activity
AYR52_RS10200	COG0745	RESPONSE REGULATOR receiver
AYR52_RS10215	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AYR52_RS10225	COG0352	thiamine-phosphate diphosphorylase activity
AYR52_RS10230	COG0351	phosphomethylpyrimidine kinase
AYR52_RS10235	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
AYR52_RS10250	COG0305	Participates in initiation and elongation during chromosome replication
AYR52_RS10255	COG0359	binds to the 23S rRNA
AYR52_RS10270	COG0629	single-stranded DNA binding
AYR52_RS10275	COG0360	Binds together with S18 to 16S ribosomal RNA
AYR52_RS10285	COG0187	DNA topoisomerase II activity
AYR52_RS10290	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AYR52_RS10300	COG0592	DNA-directed DNA polymerase activity
AYR52_RS10305	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AYR52_RS10310	COG0594	ribonuclease P activity
AYR52_RS10315	COG0706	membrane insertase activity
AYR52_RS10325	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AYR52_RS10330	COG0445	tRNA wobble uridine modification
AYR52_RS10345	COG2814	Major facilitator Superfamily
AYR52_RS10360	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AYR52_RS10370	COG3328	transposase activity
AYR52_RS10375	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AYR52_RS10380	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AYR52_RS10395	COG1968	undecaprenyl-diphosphatase activity
AYR52_RS10410	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AYR52_RS10415	COG0004	ammonium transporteR
AYR52_RS10420	COG0346	lactoylglutathione lyase activity
AYR52_RS10425	COG4989	oxidoreductase activity
AYR52_RS10430	COG2246	polysaccharide biosynthetic process
AYR52_RS10435	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AYR52_RS10435	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AYR52_RS10460	COG0673	inositol 2-dehydrogenase activity
AYR52_RS10465	COG0477	Major facilitator Superfamily
AYR52_RS10470	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AYR52_RS10475	COG3830	Belongs to the UPF0237 family
AYR52_RS10480	COG2848	UPF0210 protein
AYR52_RS10490	COG2246	polysaccharide biosynthetic process
AYR52_RS10500	COG0463	Glycosyl transferase, family 2
AYR52_RS10510	COG0586	Pfam SNARE associated Golgi protein
AYR52_RS10515	COG0642	Histidine kinase
AYR52_RS10520	COG0745	RESPONSE REGULATOR receiver
AYR52_RS10530	COG1114	Component of the transport system for branched-chain amino acids
AYR52_RS10535	COG0561	phosphatase activity
AYR52_RS10545	COG1263	PTS System
AYR52_RS10545	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AYR52_RS10545	COG2190	(PTS) system
AYR52_RS10550	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AYR52_RS10555	COG1554	hydrolase, family 65, central catalytic
AYR52_RS10610	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AYR52_RS10615	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AYR52_RS10620	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AYR52_RS10625	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AYR52_RS10630	COG4716	Myosin-crossreactive antigen
AYR52_RS10655	COG1764	response to oxidative stress
AYR52_RS10665	COG0095	Lipoate-protein ligase
AYR52_RS10670	COG0406	alpha-ribazole phosphatase activity
AYR52_RS10680	COG1393	Belongs to the ArsC family
AYR52_RS10685	COG0667	Aldo Keto reductase
AYR52_RS10710	COG1174	glycine betaine transport
AYR52_RS10715	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AYR52_RS10720	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AYR52_RS10725	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AYR52_RS10735	COG0047	phosphoribosylformylglycinamidine synthase activity
AYR52_RS10750	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AYR52_RS10755	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AYR52_RS10760	COG0138	bifunctional purine biosynthesis protein purh
AYR52_RS10765	COG0151	Belongs to the GarS family
AYR52_RS10840	COG0517	IMP dehydrogenase activity
AYR52_RS10845	COG0328	RNA-DNA hybrid ribonuclease activity
AYR52_RS10850	COG1316	TRANSCRIPTIONal
AYR52_RS10870	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AYR52_RS10890	COG0667	Aldo Keto reductase
AYR52_RS10900	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AYR52_RS10905	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
AYR52_RS10920	COG3475	LICD family
AYR52_RS10930	COG1393	Belongs to the ArsC family
AYR52_RS10935	COG0583	DNA-binding transcription factor activity
AYR52_RS10940	COG2855	membrane
AYR52_RS10945	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AYR52_RS10955	COG2738	Putative neutral zinc metallopeptidase
AYR52_RS10965	COG3442	glutamine amidotransferase
AYR52_RS10975	COG0438	transferase activity, transferring glycosyl groups
AYR52_RS10990	COG0516	GMP reductase activity
AYR52_RS10990	COG0517	IMP dehydrogenase activity
AYR52_RS11015	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AYR52_RS11020	COG0287	Prephenate dehydrogenase
AYR52_RS11025	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AYR52_RS11030	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AYR52_RS11040	COG1033	growth of symbiont in host cell
AYR52_RS11040	COG2409	Drug exporters of the RND superfamily
AYR52_RS11050	COG2814	Major facilitator Superfamily
AYR52_RS11055	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AYR52_RS11060	COG1121	(ABC) transporter
AYR52_RS11080	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AYR52_RS11110	COG2076	Multidrug Resistance protein
AYR52_RS11115	COG2076	Multidrug Resistance protein
AYR52_RS11140	COG1846	Transcriptional regulator
AYR52_RS11145	COG1929	Belongs to the glycerate kinase type-1 family
AYR52_RS11165	COG2190	(PTS) system
AYR52_RS11165	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AYR52_RS11165	COG1263	PTS System
AYR52_RS11170	COG3711	transcriptional antiterminator
AYR52_RS11175	COG2190	(PTS) system
AYR52_RS11175	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AYR52_RS11175	COG1263	PTS System
AYR52_RS11180	COG2723	6-phospho-beta-galactosidase activity
AYR52_RS11205	COG0561	phosphatase activity
AYR52_RS11215	COG0730	response to heat
AYR52_RS11235	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
AYR52_RS11245	COG0561	phosphatase activity
AYR52_RS11250	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AYR52_RS11255	COG1181	Belongs to the D-alanine--D-alanine ligase family
AYR52_RS11260	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AYR52_RS11270	COG0583	DNA-binding transcription factor activity
AYR52_RS11280	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AYR52_RS11295	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AYR52_RS11300	COG0131	Imidazoleglycerol-phosphate dehydratase
AYR52_RS11310	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AYR52_RS11315	COG0107	imidazoleglycerol-phosphate synthase activity
AYR52_RS11320	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AYR52_RS11325	COG0140	phosphoribosyl-ATP diphosphatase activity
AYR52_RS11330	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AYR52_RS11340	COG1733	regulation of RNA biosynthetic process
AYR52_RS11345	COG1446	asparaginase
AYR52_RS11370	COG2814	Major facilitator Superfamily
AYR52_RS11400	COG0861	Integral membrane protein TerC family
AYR52_RS11415	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AYR52_RS11435	COG2261	transglycosylase associated protein
AYR52_RS11450	COG1302	Protein conserved in bacteria
AYR52_RS11470	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AYR52_RS11475	COG0386	Belongs to the glutathione peroxidase family
AYR52_RS11515	COG0673	inositol 2-dehydrogenase activity
AYR52_RS11530	COG0783	Belongs to the Dps family
AYR52_RS11535	COG0300	oxidoreductase activity
AYR52_RS11585	COG2814	Major facilitator Superfamily
AYR52_RS11595	COG2151	metal-sulfur cluster biosynthetic enzyme
AYR52_RS11600	COG0129	dihydroxy-acid dehydratase activity
AYR52_RS11610	COG0028	Belongs to the TPP enzyme family
AYR52_RS11615	COG0440	acetolactate synthase activity
AYR52_RS11625	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AYR52_RS11630	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AYR52_RS11635	COG1119	ATPase activity
AYR52_RS11645	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AYR52_RS11685	COG0671	phosphoesterase, PA-phosphatase related
AYR52_RS11700	COG0488	(ABC) transporter
AYR52_RS11715	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AYR52_RS11720	COG1760	l-serine dehydratase
AYR52_RS11725	COG1760	l-serine dehydratase
AYR52_RS11735	COG3001	Fructosamine kinase
AYR52_RS11785	COG3973	AAA domain
AYR52_RS11795	COG1125	glycine betaine transport
AYR52_RS11795	COG0517	IMP dehydrogenase activity
AYR52_RS11800	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AYR52_RS11835	COG1192	Involved in chromosome partitioning
AYR52_RS11845	COG2801	Transposase and inactivated derivatives
AYR52_RS11855	COG3158	transport of potassium into the cell
AYR52_RS11880	COG0477	Major facilitator Superfamily
AYR52_RS11885	COG1418	mRNA catabolic process
AYR52_RS11895	COG2801	Transposase and inactivated derivatives
AYR52_RS11900	COG2376	Dihydroxyacetone kinase
AYR52_RS11905	COG1461	Dihydroxyacetone kinase
AYR52_RS11910	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
AYR52_RS11915	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AYR52_RS11925	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AYR52_RS11975	COG1192	Involved in chromosome partitioning
AYR52_RS11990	COG1393	Belongs to the ArsC family
AYR52_RS12005	COG1192	Involved in chromosome partitioning
AYR52_RS12015	COG2801	Transposase and inactivated derivatives
AYR52_RS12020	COG1228	amidohydrolase
AYR52_RS12055	COG0789	Transcriptional regulator
AYR52_RS12090	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AYR52_RS12130	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AYR52_RS12140	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AYR52_RS12155	COG1028	Short-chain dehydrogenase reductase Sdr
AYR52_RS12160	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AYR52_RS12165	COG0511	ligase activity, forming carbon-carbon bonds
AYR52_RS12170	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AYR52_RS12180	COG0439	Biotin carboxylase
AYR52_RS12185	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AYR52_RS12190	COG0825	malonyl-CoA metabolic process
AYR52_RS12195	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AYR52_RS12210	COG1268	BioY protein
AYR52_RS12220	COG1442	glycosyl transferase family 8
AYR52_RS12225	COG1132	(ABC) transporter
AYR52_RS12235	COG1442	glycosyl transferase family 8
AYR52_RS12250	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AYR52_RS12270	COG2261	transglycosylase associated protein
AYR52_RS12280	COG1393	Belongs to the ArsC family
AYR52_RS12300	COG2261	transglycosylase associated protein
AYR52_RS12310	COG1597	lipid kinase activity
AYR52_RS12325	COG1192	Involved in chromosome partitioning
AYR52_RS12330	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AYR52_RS12345	COG2801	Transposase and inactivated derivatives
AYR52_RS12355	COG1609	Transcriptional regulator
AYR52_RS12370	COG2017	converts alpha-aldose to the beta-anomer
AYR52_RS12375	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AYR52_RS12430	COG2217	Heavy metal translocating P-type atpase
AYR52_RS12555	COG1268	BioY protein
AYR52_RS12570	COG3684	Belongs to the aldolase LacD family
AYR52_RS12585	COG2801	Transposase and inactivated derivatives
AYR52_RS12645	COG0589	response to stress
AYR52_RS12660	COG2801	Transposase and inactivated derivatives
AYR52_RS12665	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AYR52_RS12670	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AYR52_RS12675	COG0148	phosphopyruvate hydratase activity
AYR52_RS12725	COG0582	viral genome integration into host DNA
AYR52_RS12740	COG0463	Glycosyl transferase, family 2
AYR52_RS12770	COG0431	NADPH-dependent FMN reductase
AYR52_RS12770	COG3976	FMN-binding domain protein
AYR52_RS12770	COG1053	succinate dehydrogenase
AYR52_RS12775	COG0583	DNA-binding transcription factor activity
AYR52_RS12785	COG0789	Transcriptional regulator
AYR52_RS12805	COG0582	viral genome integration into host DNA
AYR52_RS12850	COG4372	Transposase
AYR52_RS12895	COG0302	gtp cyclohydrolase
AYR52_RS12900	COG1028	Short-chain dehydrogenase reductase Sdr
AYR52_RS12915	COG3189	MarR family transcriptional regulator
AYR52_RS12925	COG3328	transposase activity
AYR52_RS12995	COG0463	Glycosyl transferase, family 2
AYR52_RS13095	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
AYR52_RS13110	COG2963	transposase activity
AYR52_RS13115	COG2801	Transposase and inactivated derivatives
AYR52_RS13150	COG2409	Drug exporters of the RND superfamily
AYR52_RS13150	COG1033	growth of symbiont in host cell
AYR52_RS13170	COG1268	BioY protein
AYR52_RS13175	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AYR52_RS13185	COG2801	Transposase and inactivated derivatives
AYR52_RS13200	COG0589	response to stress
AYR52_RS13225	COG1192	Involved in chromosome partitioning
AYR52_RS13230	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AYR52_RS13255	COG2801	Transposase and inactivated derivatives
AYR52_RS13270	COG3684	Belongs to the aldolase LacD family
AYR52_RS13280	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AYR52_RS13295	COG1674	ftsk spoiiie
AYR52_RS13300	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AYR52_RS13305	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AYR52_RS13365	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AYR52_RS13595	COG0509	glycine decarboxylation via glycine cleavage system