locus-tag	class	description
I6N93_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I6N93_RS00010	COG0592	DNA-directed DNA polymerase activity
I6N93_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I6N93_RS00035	COG0742	ribosomal rna small subunit methyltransferase
I6N93_RS00040	COG0339	signal peptide processing
I6N93_RS00055	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
I6N93_RS00070	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6N93_RS00085	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6N93_RS00095	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
I6N93_RS00100	COG0837	glucose binding
I6N93_RS00105	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6N93_RS00110	COG3338	carbonate dehydratase activity
I6N93_RS00125	COG4221	oxidoreductase activity
I6N93_RS00130	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6N93_RS00140	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6N93_RS00145	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6N93_RS00150	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6N93_RS00155	COG1309	transcriptional regulator
I6N93_RS00160	COG0493	'glutamate synthase
I6N93_RS00180	COG3977	Valine--pyruvate aminotransferase
I6N93_RS00190	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6N93_RS00195	COG2188	Transcriptional regulator
I6N93_RS00200	COG1397	ADP-ribosylglycohydrolase
I6N93_RS00205	COG2211	Major facilitator Superfamily
I6N93_RS00210	COG2818	Glycosylase
I6N93_RS00215	COG0730	response to heat
I6N93_RS00220	COG0752	glycyl-tRNA synthetase alpha subunit
I6N93_RS00225	COG0751	glycine-tRNA ligase activity
I6N93_RS00235	COG0840	transmembrane signaling receptor activity
I6N93_RS00240	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6N93_RS00245	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I6N93_RS00250	COG1012	belongs to the aldehyde dehydrogenase family
I6N93_RS00255	COG3274	enterobacterial common antigen metabolic process
I6N93_RS00265	COG0137	argininosuccinate synthase activity
I6N93_RS00285	COG2200	EAL domain
I6N93_RS00290	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
I6N93_RS00315	COG3623	hexulose-6-phosphate isomerase
I6N93_RS00330	COG2188	Transcriptional regulator
I6N93_RS00340	COG2222	sugar isomerase
I6N93_RS00345	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6N93_RS00380	COG1561	YicC-like family, N-terminal region
I6N93_RS00385	COG0583	DNA-binding transcription factor activity
I6N93_RS00395	COG0747	negative chemotaxis
I6N93_RS00400	COG0601	transmembrane transport
I6N93_RS00405	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6N93_RS00410	COG0444	Belongs to the ABC transporter superfamily
I6N93_RS00415	COG4608	Belongs to the ABC transporter superfamily
I6N93_RS00440	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6N93_RS00445	COG0601	transmembrane transport
I6N93_RS00450	COG0747	negative chemotaxis
I6N93_RS00455	COG4172	Belongs to the ABC transporter superfamily
I6N93_RS00460	COG4948	Mandelate Racemase Muconate Lactonizing
I6N93_RS00475	COG2149	membrane
I6N93_RS00480	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
I6N93_RS00490	COG1309	transcriptional regulator
I6N93_RS00495	COG0756	dUTP diphosphatase activity
I6N93_RS00500	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I6N93_RS00505	COG2003	Belongs to the UPF0758 family
I6N93_RS00520	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I6N93_RS00525	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
I6N93_RS00535	COG1519	Transferase
I6N93_RS00540	COG0438	transferase activity, transferring glycosyl groups
I6N93_RS00545	COG0438	transferase activity, transferring glycosyl groups
I6N93_RS00550	COG0859	PFAM glycosyl transferase family 9
I6N93_RS00560	COG0859	PFAM glycosyl transferase family 9
I6N93_RS00575	COG0859	PFAM glycosyl transferase family 9
I6N93_RS00580	COG0859	PFAM glycosyl transferase family 9
I6N93_RS00585	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6N93_RS00590	COG2861	carbohydrate metabolic process
I6N93_RS00595	COG4942	peptidase
I6N93_RS00600	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6N93_RS00605	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
I6N93_RS00610	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I6N93_RS00630	COG0583	DNA-binding transcription factor activity
I6N93_RS00635	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I6N93_RS00645	COG1028	Short-chain dehydrogenase reductase Sdr
I6N93_RS00665	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
I6N93_RS00670	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6N93_RS00675	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I6N93_RS00680	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6N93_RS00685	COG0165	Argininosuccinate lyase
I6N93_RS00690	COG1322	Protein conserved in bacteria
I6N93_RS00695	COG2226	methyltransferase
I6N93_RS00700	COG3165	ubiquinone biosynthetic process from chorismate
I6N93_RS00705	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I6N93_RS00710	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6N93_RS00720	COG0805	protein transport
I6N93_RS00725	COG0084	hydrolase, TatD family'
I6N93_RS00740	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I6N93_RS00750	COG0006	proline dipeptidase activity
I6N93_RS00755	COG1739	Uncharacterized protein family UPF0029
I6N93_RS00800	COG0583	DNA-binding transcription factor activity
I6N93_RS00810	COG0606	chelatase, subunit chli
I6N93_RS00825	COG3978	acetolactate synthase activity
I6N93_RS00835	COG0129	dihydroxy-acid dehydratase activity
I6N93_RS00840	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6N93_RS00850	COG0583	DNA-binding transcription factor activity
I6N93_RS00860	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6N93_RS00870	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
I6N93_RS00875	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6N93_RS00880	COG0210	DNA helicase
I6N93_RS00890	COG0248	Ppx GppA phosphatase
I6N93_RS00900	COG3118	belongs to the thioredoxin family
I6N93_RS00905	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
I6N93_RS00910	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6N93_RS00920	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I6N93_RS00925	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
I6N93_RS00930	COG0456	acetyltransferase
I6N93_RS00935	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I6N93_RS00940	COG2244	polysaccharide biosynthetic process
I6N93_RS00945	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I6N93_RS00955	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
I6N93_RS00960	COG1113	amino acid transport
I6N93_RS01005	COG1473	amidohydrolase
I6N93_RS01010	COG3071	HemY protein
I6N93_RS01015	COG2959	enzyme of heme biosynthesis
I6N93_RS01020	COG1587	Uroporphyrinogen-III synthase
I6N93_RS01025	COG0181	hydroxymethylbilane synthase activity
I6N93_RS01040	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I6N93_RS01055	COG1011	Hydrolase
I6N93_RS01060	COG0210	DNA helicase
I6N93_RS01065	COG0598	Magnesium transport protein CorA
I6N93_RS01085	COG1280	lysine exporter protein (LysE YggA)
I6N93_RS01090	COG1280	lysine exporter protein (LysE YggA)
I6N93_RS01095	COG2267	carboxylic ester hydrolase activity
I6N93_RS01100	COG0561	phosphatase activity
I6N93_RS01105	COG1741	Belongs to the pirin family
I6N93_RS01110	COG1609	Transcriptional regulator
I6N93_RS01115	COG2610	gluconate transmembrane transporter activity
I6N93_RS01120	COG2095	MarC family integral membrane protein
I6N93_RS01125	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6N93_RS01130	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I6N93_RS01135	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6N93_RS01140	COG0705	Rhomboid family
I6N93_RS01145	COG1349	DNA-binding transcription factor activity
I6N93_RS01150	COG1640	4-alpha-glucanotransferase
I6N93_RS01155	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
I6N93_RS01155	COG0316	Belongs to the HesB IscA family
I6N93_RS01160	COG1040	competence protein
I6N93_RS01165	COG2267	carboxylic ester hydrolase activity
I6N93_RS01170	COG1785	Belongs to the alkaline phosphatase family
I6N93_RS01180	COG2183	response to ionizing radiation
I6N93_RS01190	COG0028	Belongs to the TPP enzyme family
I6N93_RS01200	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6N93_RS01215	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
I6N93_RS01220	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
I6N93_RS01225	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I6N93_RS01230	COG1011	Hydrolase
I6N93_RS01240	COG0494	nUDIX hydrolase
I6N93_RS01245	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
I6N93_RS01270	COG4796	Type ii and iii secretion system protein
I6N93_RS01275	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I6N93_RS01280	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I6N93_RS01295	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6N93_RS01300	COG0546	phosphoglycolate phosphatase activity
I6N93_RS01310	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6N93_RS01330	COG1765	OsmC-like protein
I6N93_RS01335	COG3954	Phosphoribulokinase
I6N93_RS01345	COG0429	hydrolase of the alpha beta-hydrolase fold
I6N93_RS01355	COG0488	(ABC) transporter
I6N93_RS01360	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6N93_RS01365	COG0475	glutathione-regulated potassium exporter activity
I6N93_RS01365	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6N93_RS01375	COG1047	Peptidyl-prolyl cis-trans
I6N93_RS01395	COG2900	Belongs to the SlyX family
I6N93_RS01400	COG0545	Peptidyl-prolyl cis-trans isomerase
I6N93_RS01405	COG2964	Protein conserved in bacteria
I6N93_RS01410	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
I6N93_RS01415	COG2923	Belongs to the DsrF TusC family
I6N93_RS01425	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I6N93_RS01430	COG0049	tRNA binding
I6N93_RS01440	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6N93_RS01455	COG0051	transcription antitermination factor activity, RNA binding
I6N93_RS01460	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I6N93_RS01465	COG0088	Forms part of the polypeptide exit tunnel
I6N93_RS01470	COG0089	rRNA binding
I6N93_RS01480	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I6N93_RS01490	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
I6N93_RS01495	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I6N93_RS01515	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
I6N93_RS01520	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
I6N93_RS01525	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I6N93_RS01530	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I6N93_RS01535	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
I6N93_RS01540	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
I6N93_RS01545	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I6N93_RS01550	COG1841	ribosomal large subunit assembly
I6N93_RS01555	COG0200	Binds to the 23S rRNA
I6N93_RS01560	COG0201	protein transport
I6N93_RS01565	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I6N93_RS01570	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I6N93_RS01580	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I6N93_RS01590	COG0203	ribosomal protein L17
I6N93_RS01610	COG1970	mechanosensitive ion channel activity
I6N93_RS01615	COG0569	domain protein
I6N93_RS01620	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6N93_RS01620	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6N93_RS01625	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I6N93_RS01630	COG0242	peptide deformylase activity
I6N93_RS01635	COG0758	DNA mediated transformation
I6N93_RS01640	COG2922	Belongs to the Smg family
I6N93_RS01645	COG0551	DNA topoisomerase type I activity
I6N93_RS01655	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6N93_RS01665	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6N93_RS01695	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
I6N93_RS01700	COG0471	metal ion transport
I6N93_RS01705	COG0527	aspartate kinase activity
I6N93_RS01710	COG0166	Belongs to the GPI family
I6N93_RS01725	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I6N93_RS01735	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
I6N93_RS01740	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
I6N93_RS01745	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6N93_RS01750	COG1053	succinate dehydrogenase
I6N93_RS01755	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
I6N93_RS01760	COG3264	Mechanosensitive ion channel
I6N93_RS01760	COG1511	domain protein
I6N93_RS01765	COG0688	phosphatidylethanolamine metabolic process
I6N93_RS01770	COG1162	GTPase activity
I6N93_RS01775	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
I6N93_RS01795	COG0366	Alpha amylase catalytic
I6N93_RS01815	COG0583	DNA-binding transcription factor activity
I6N93_RS01825	COG1846	Transcriptional regulator
I6N93_RS01830	COG1764	response to oxidative stress
I6N93_RS01835	COG2271	Major facilitator Superfamily
I6N93_RS01855	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I6N93_RS01855	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I6N93_RS01860	COG0802	atpase or kinase
I6N93_RS01865	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6N93_RS01870	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I6N93_RS01875	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I6N93_RS01880	COG1923	regulation of RNA biosynthetic process
I6N93_RS01885	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6N93_RS01890	COG0330	HflC and HflK could
I6N93_RS01895	COG0330	HflC and HflK could
I6N93_RS01900	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
I6N93_RS01905	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I6N93_RS01910	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6N93_RS01915	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
I6N93_RS01920	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I6N93_RS01925	COG1678	Uncharacterized ACR, COG1678
I6N93_RS01930	COG0189	ligase activity
I6N93_RS01935	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6N93_RS01940	COG2356	endonuclease I
I6N93_RS01945	COG3091	SprT-like family
I6N93_RS01950	COG2814	Major facilitator Superfamily
I6N93_RS01955	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I6N93_RS01960	COG1166	arginine decarboxylase activity
I6N93_RS01965	COG0501	Belongs to the peptidase M48B family
I6N93_RS01970	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6N93_RS01975	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6N93_RS01980	COG0126	phosphoglycerate kinase activity
I6N93_RS01990	COG0668	transmembrane transport
I6N93_RS01995	COG2968	Membrane
I6N93_RS02000	COG0583	DNA-binding transcription factor activity
I6N93_RS02005	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
I6N93_RS02010	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6N93_RS02015	COG0604	alcohol dehydrogenase
I6N93_RS02030	COG0488	(ABC) transporter
I6N93_RS02040	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
I6N93_RS02045	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
I6N93_RS02050	COG0406	alpha-ribazole phosphatase activity
I6N93_RS02055	COG2207	Transcriptional regulator
I6N93_RS02055	COG3708	Transcriptional regulator
I6N93_RS02060	COG3045	CreA protein
I6N93_RS02065	COG0745	RESPONSE REGULATOR receiver
I6N93_RS02070	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
I6N93_RS02085	COG0083	homoserine kinase activity
I6N93_RS02095	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I6N93_RS02105	COG1609	Transcriptional regulator
I6N93_RS02110	COG3022	response to hydroperoxide
I6N93_RS02120	COG3706	GGDEF domain
I6N93_RS02125	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6N93_RS02135	COG0443	Heat shock 70 kDa protein
I6N93_RS02140	COG0484	heat shock protein binding
I6N93_RS02150	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I6N93_RS02155	COG0268	Binds directly to 16S ribosomal RNA
I6N93_RS02160	COG0196	riboflavin kinase activity
I6N93_RS02165	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I6N93_RS02170	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I6N93_RS02175	COG1047	Peptidyl-prolyl cis-trans
I6N93_RS02180	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
I6N93_RS02185	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I6N93_RS02190	COG0505	Belongs to the CarA family
I6N93_RS02195	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I6N93_RS02200	COG1028	Short-chain dehydrogenase reductase Sdr
I6N93_RS02205	COG2966	Psort location CytoplasmicMembrane, score
I6N93_RS02210	COG3610	response to peptide
I6N93_RS02215	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I6N93_RS02220	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6N93_RS02225	COG2967	ApaG domain
I6N93_RS02230	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I6N93_RS02235	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I6N93_RS02240	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6N93_RS02245	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
I6N93_RS02250	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
I6N93_RS02255	COG0564	pseudouridine synthase activity
I6N93_RS02260	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I6N93_RS02265	COG0417	DNA replication proofreading
I6N93_RS02285	COG0411	ABC transporter
I6N93_RS02295	COG0586	Pfam SNARE associated Golgi protein
I6N93_RS02300	COG0440	acetolactate synthase activity
I6N93_RS02305	COG0028	Belongs to the TPP enzyme family
I6N93_RS02315	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
I6N93_RS02325	COG4143	(ABC) transporter
I6N93_RS02330	COG4533	DNA binding
I6N93_RS02340	COG0477	Major facilitator Superfamily
I6N93_RS02355	COG0066	3-isopropylmalate dehydratase activity
I6N93_RS02360	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I6N93_RS02365	COG0473	3-isopropylmalate dehydrogenase activity
I6N93_RS02370	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6N93_RS02390	COG2001	Belongs to the MraZ family
I6N93_RS02395	COG0275	rRNA processing
I6N93_RS02400	COG3116	cell division
I6N93_RS02405	COG0768	penicillin binding
I6N93_RS02410	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6N93_RS02415	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6N93_RS02420	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6N93_RS02425	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I6N93_RS02430	COG0772	Belongs to the SEDS family
I6N93_RS02435	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I6N93_RS02440	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6N93_RS02445	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6N93_RS02450	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I6N93_RS02455	COG0849	cell division
I6N93_RS02460	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I6N93_RS02465	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
I6N93_RS02480	COG0653	protein targeting
I6N93_RS02485	COG0494	nUDIX hydrolase
I6N93_RS02490	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
I6N93_RS02495	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
I6N93_RS02500	COG0237	dephospho-CoA kinase activity
I6N93_RS02505	COG0516	GMP reductase activity
I6N93_RS02510	COG1459	type II secretion system
I6N93_RS02515	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6N93_RS02520	COG4969	Belongs to the N-Me-Phe pilin family
I6N93_RS02530	COG3725	Membrane protein required for beta-lactamase induction
I6N93_RS02535	COG1113	amino acid transport
I6N93_RS02545	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I6N93_RS02550	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6N93_RS02555	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6N93_RS02565	COG4771	TonB-dependent receptor
I6N93_RS02580	COG3112	Uncharacterised protein family (UPF0231)
I6N93_RS02590	COG0246	Mannitol dehydrogenase
I6N93_RS02595	COG5297	Belongs to the glycosyl hydrolase family 6
I6N93_RS02615	COG0432	Pfam Uncharacterised protein family UPF0047
I6N93_RS02625	COG0840	transmembrane signaling receptor activity
I6N93_RS02630	COG1448	Aminotransferase
I6N93_RS02640	COG1522	sequence-specific DNA binding
I6N93_RS02655	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6N93_RS02675	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6N93_RS02685	COG0583	DNA-binding transcription factor activity
I6N93_RS02695	COG2610	gluconate transmembrane transporter activity
I6N93_RS02700	COG1929	Belongs to the glycerate kinase type-1 family
I6N93_RS02705	COG3835	regulator
I6N93_RS02710	COG1609	Transcriptional regulator
I6N93_RS02715	COG0204	Acyl-transferase
I6N93_RS02715	COG0318	PFAM AMP-dependent synthetase and ligase
I6N93_RS02720	COG0477	Major facilitator Superfamily
I6N93_RS02725	COG2153	protein acetylation
I6N93_RS02730	COG5510	response to toxic substance
I6N93_RS02735	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6N93_RS02740	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
I6N93_RS02745	COG1872	DUF167
I6N93_RS02750	COG0762	integral membrane protein
I6N93_RS02755	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I6N93_RS02760	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I6N93_RS02770	COG0402	S-adenosylhomocysteine deaminase activity
I6N93_RS02785	COG0840	transmembrane signaling receptor activity
I6N93_RS02795	COG0557	exoribonuclease II activity
I6N93_RS02800	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6N93_RS02810	COG3650	response to hydrogen peroxide
I6N93_RS02820	COG1073	alpha beta
I6N93_RS02825	COG0360	Binds together with S18 to 16S ribosomal RNA
I6N93_RS02835	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I6N93_RS02840	COG0359	binds to the 23S rRNA
I6N93_RS02845	COG3061	Opacity-associated protein A
I6N93_RS02850	COG0545	Peptidyl-prolyl cis-trans isomerase
I6N93_RS02865	COG0601	transmembrane transport
I6N93_RS02870	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6N93_RS02875	COG4608	Belongs to the ABC transporter superfamily
I6N93_RS02880	COG0444	Belongs to the ABC transporter superfamily
I6N93_RS02890	COG1218	3'(2'),5'-bisphosphate nucleotidase
I6N93_RS02900	COG1253	flavin adenine dinucleotide binding
I6N93_RS02905	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6N93_RS02910	COG0729	surface antigen
I6N93_RS02915	COG2911	Protein conserved in bacteria
I6N93_RS02920	COG2105	PFAM AIG2 family protein
I6N93_RS02925	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I6N93_RS02930	COG0840	transmembrane signaling receptor activity
I6N93_RS02940	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I6N93_RS02945	COG1968	undecaprenyl-diphosphatase activity
I6N93_RS02950	COG0617	tRNA 3'-terminal CCA addition
I6N93_RS02955	COG4991	sh3 domain protein
I6N93_RS02960	COG3025	triphosphatase activity
I6N93_RS02965	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
I6N93_RS02970	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
I6N93_RS02970	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I6N93_RS02975	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I6N93_RS02980	COG3530	Putative quorum-sensing-regulated virulence factor
I6N93_RS02995	COG0840	transmembrane signaling receptor activity
I6N93_RS03000	COG4999	Histidine kinase
I6N93_RS03000	COG3437	response regulator, receiver
I6N93_RS03000	COG2205	protein histidine kinase activity
I6N93_RS03000	COG3850	Histidine kinase
I6N93_RS03005	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6N93_RS03010	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6N93_RS03015	COG3956	TIGRFAM MazG family protein
I6N93_RS03020	COG0504	CTP synthase activity
I6N93_RS03025	COG0148	phosphopyruvate hydratase activity
I6N93_RS03035	COG0602	queuosine metabolic process
I6N93_RS03040	COG0720	synthase
I6N93_RS03045	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I6N93_RS03050	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6N93_RS03055	COG0175	sulfate reduction
I6N93_RS03060	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6N93_RS03060	COG1648	precorrin-2 dehydrogenase activity
I6N93_RS03070	COG2895	sulfate adenylyltransferase (ATP) activity
I6N93_RS03085	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
I6N93_RS03090	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
I6N93_RS03095	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
I6N93_RS03100	COG0585	pseudouridine synthase activity
I6N93_RS03105	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
I6N93_RS03120	COG0442	prolyl-tRNA aminoacylation
I6N93_RS03125	COG1720	tRNA m6t6A37 methyltransferase activity
I6N93_RS03140	COG2011	ABC-type metal ion transport system permease component
I6N93_RS03145	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6N93_RS03150	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I6N93_RS03185	COG0477	Major facilitator Superfamily
I6N93_RS03190	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6N93_RS03195	COG3148	PFAM DTW domain containing protein
I6N93_RS03200	COG3118	belongs to the thioredoxin family
I6N93_RS03205	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6N93_RS03210	COG1621	beta-fructofuranosidase activity
I6N93_RS03215	COG2814	Major facilitator Superfamily
I6N93_RS03220	COG1566	PFAM secretion protein HlyD family protein
I6N93_RS03225	COG1846	Transcriptional regulator
I6N93_RS03230	COG2814	Major facilitator Superfamily
I6N93_RS03235	COG2113	Glycine betaine
I6N93_RS03240	COG4176	ABC-type proline glycine betaine transport system permease component
I6N93_RS03245	COG4175	Glycine betaine
I6N93_RS03255	COG0366	Alpha amylase catalytic
I6N93_RS03265	COG0366	Alpha amylase catalytic
I6N93_RS03270	COG1953	Uracil, thiamine, allantoin
I6N93_RS03325	COG0765	amino acid transport
I6N93_RS03330	COG0765	amino acid transport
I6N93_RS03335	COG1126	abc transporter atp-binding protein
I6N93_RS03340	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I6N93_RS03355	COG0436	Aminotransferase
I6N93_RS03370	COG0235	Class ii aldolase
I6N93_RS03375	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
I6N93_RS03380	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
I6N93_RS03385	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
I6N93_RS03390	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
I6N93_RS03395	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
I6N93_RS03400	COG0121	glutamine amidotransferase
I6N93_RS03405	COG3034	peptidoglycan biosynthetic process
I6N93_RS03415	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6N93_RS03420	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6N93_RS03425	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
I6N93_RS03430	COG1073	alpha beta
I6N93_RS03440	COG2199	diguanylate cyclase activity
I6N93_RS03445	COG2885	chlorophyll binding
I6N93_RS03455	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I6N93_RS03460	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
I6N93_RS03525	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6N93_RS03535	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6N93_RS03535	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
I6N93_RS03540	COG1022	Amp-dependent synthetase and ligase
I6N93_RS03590	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
I6N93_RS03670	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6N93_RS03675	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6N93_RS03685	COG0318	PFAM AMP-dependent synthetase and ligase
I6N93_RS03700	COG0019	diaminopimelate decarboxylase activity
I6N93_RS03715	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6N93_RS03750	COG0577	efflux transmembrane transporter activity
I6N93_RS03750	COG1136	(ABC) transporter
I6N93_RS03770	COG1780	Probably involved in ribonucleotide reductase function
I6N93_RS03780	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
I6N93_RS03785	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
I6N93_RS03800	COG3842	ATPase activity
I6N93_RS03805	COG3344	reverse transcriptase
I6N93_RS03860	COG0741	lytic transglycosylase activity
I6N93_RS04020	COG1196	nuclear chromosome segregation
I6N93_RS04085	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
I6N93_RS04095	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
I6N93_RS04135	COG3423	Transcriptional regulator
I6N93_RS04145	COG0582	viral genome integration into host DNA
I6N93_RS04155	COG1982	Orn Lys Arg decarboxylase major
I6N93_RS04165	COG0741	lytic transglycosylase activity
I6N93_RS04170	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
I6N93_RS04185	COG3171	Protein conserved in bacteria
I6N93_RS04200	COG0667	Aldo Keto reductase
I6N93_RS04210	COG0861	Integral membrane protein TerC family
I6N93_RS04215	COG3066	DNA modification
I6N93_RS04220	COG0494	nUDIX hydrolase
I6N93_RS04230	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
I6N93_RS04235	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
I6N93_RS04245	COG4795	General secretion pathway protein
I6N93_RS04260	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
I6N93_RS04265	COG1074	ATP-dependent DNA helicase activity
I6N93_RS04270	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6N93_RS04275	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6N93_RS04275	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I6N93_RS04280	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6N93_RS04300	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
I6N93_RS04305	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I6N93_RS04310	COG2166	iron-sulfur cluster assembly
I6N93_RS04315	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6N93_RS04325	COG0583	DNA-binding transcription factor activity
I6N93_RS04330	COG2363	Small membrane protein
I6N93_RS04335	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
I6N93_RS04340	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6N93_RS04345	COG1611	Belongs to the LOG family
I6N93_RS04380	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
I6N93_RS04395	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I6N93_RS04400	COG0528	UMP kinase activity
I6N93_RS04405	COG0233	cytoplasmic translational termination
I6N93_RS04410	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
I6N93_RS04415	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6N93_RS04420	COG0575	Belongs to the CDS family
I6N93_RS04425	COG0750	zinc metalloprotease
I6N93_RS04430	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6N93_RS04435	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
I6N93_RS04440	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6N93_RS04445	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6N93_RS04455	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6N93_RS04460	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I6N93_RS04470	COG0825	malonyl-CoA metabolic process
I6N93_RS04475	COG0346	lactoylglutathione lyase activity
I6N93_RS04480	COG0037	tRNA processing
I6N93_RS04485	COG4568	rho-dependent transcription termination
I6N93_RS04495	COG4681	YaeQ
I6N93_RS04500	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
I6N93_RS04515	COG0840	transmembrane signaling receptor activity
I6N93_RS04520	COG0371	Dehydrogenase
I6N93_RS04530	COG2824	Alkylphosphonate utilization operon protein PhnA
I6N93_RS04540	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I6N93_RS04545	COG4615	Cyclic peptide transporter
I6N93_RS04560	COG0840	transmembrane signaling receptor activity
I6N93_RS04570	COG0419	ATPase involved in DNA repair
I6N93_RS04575	COG0420	3'-5' exonuclease activity
I6N93_RS04585	COG5002	protein histidine kinase activity
I6N93_RS04590	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I6N93_RS04605	COG0450	alkyl hydroperoxide reductase
I6N93_RS04610	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
I6N93_RS04615	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
I6N93_RS04620	COG0343	queuine tRNA-ribosyltransferase activity
I6N93_RS04625	COG1862	Preprotein translocase
I6N93_RS04630	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6N93_RS04635	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6N93_RS04640	COG4238	major outer membrane lipoprotein
I6N93_RS04645	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I6N93_RS04650	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I6N93_RS04655	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6N93_RS04655	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6N93_RS04660	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I6N93_RS04665	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6N93_RS04670	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
I6N93_RS04675	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I6N93_RS04680	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
I6N93_RS04685	COG0142	geranyltranstransferase activity
I6N93_RS04695	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6N93_RS04695	COG0301	tRNA thio-modification
I6N93_RS04700	COG0693	protein deglycase activity
I6N93_RS04705	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I6N93_RS04710	COG1666	GTP binding
I6N93_RS04715	COG0506	proline dehydrogenase activity
I6N93_RS04715	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6N93_RS04715	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6N93_RS04720	COG1126	abc transporter atp-binding protein
I6N93_RS04730	COG2814	Major facilitator Superfamily
I6N93_RS04735	COG0109	protoheme IX farnesyltransferase activity
I6N93_RS04740	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I6N93_RS04745	COG1845	cytochrome c oxidase, subunit III
I6N93_RS04750	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6N93_RS04755	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I6N93_RS04760	COG2223	nitrite transmembrane transporter activity
I6N93_RS04765	COG3056	Lipoprotein
I6N93_RS04770	COG0271	Belongs to the BolA IbaG family
I6N93_RS04775	COG0544	peptidyl-prolyl cis-trans isomerase activity
I6N93_RS04780	COG0740	serine-type endopeptidase activity
I6N93_RS04785	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
I6N93_RS04790	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I6N93_RS04795	COG0776	regulation of translation
I6N93_RS04800	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6N93_RS04805	COG1555	photosystem II stabilization
I6N93_RS04810	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
I6N93_RS04820	COG1522	sequence-specific DNA binding
I6N93_RS04825	COG1132	(ABC) transporter
I6N93_RS04830	COG1132	(ABC) transporter
I6N93_RS04835	COG0347	Belongs to the P(II) protein family
I6N93_RS04840	COG0004	ammonium transporteR
I6N93_RS04845	COG1946	Acyl-CoA thioesterase
I6N93_RS04850	COG3126	Type III secretion system lipoprotein chaperone (YscW)
I6N93_RS04855	COG3695	enzyme binding
I6N93_RS04875	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6N93_RS04880	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6N93_RS04885	COG1309	transcriptional regulator
I6N93_RS04890	COG3264	Mechanosensitive ion channel
I6N93_RS04890	COG1196	nuclear chromosome segregation
I6N93_RS04910	COG2832	Protein of unknown function (DUF454)
I6N93_RS04915	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6N93_RS04925	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
I6N93_RS04930	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I6N93_RS04935	COG0326	Molecular chaperone. Has ATPase activity
I6N93_RS04940	COG0563	adenylate kinase activity
I6N93_RS04945	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I6N93_RS04955	COG4651	solute:proton antiporter activity
I6N93_RS04955	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6N93_RS04960	COG0737	Belongs to the 5'-nucleotidase family
I6N93_RS04965	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6N93_RS04970	COG3735	TraB family
I6N93_RS04975	COG1585	Membrane protein implicated in regulation of membrane protease activity
I6N93_RS04980	COG0330	HflC and HflK could
I6N93_RS04985	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6N93_RS04995	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6N93_RS05000	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6N93_RS05010	COG0784	Response regulator, receiver
I6N93_RS05010	COG2205	protein histidine kinase activity
I6N93_RS05020	COG2198	Histidine kinase
I6N93_RS05020	COG0642	Histidine kinase
I6N93_RS05025	COG2223	nitrite transmembrane transporter activity
I6N93_RS05030	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
I6N93_RS05035	COG0596	Alpha beta hydrolase
I6N93_RS05040	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
I6N93_RS05045	COG1441	menaquinone biosynthetic process
I6N93_RS05070	COG3118	belongs to the thioredoxin family
I6N93_RS05075	COG0300	oxidoreductase activity
I6N93_RS05080	COG2755	lipolytic protein G-D-S-L family
I6N93_RS05085	COG4181	ATPase activity
I6N93_RS05090	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
I6N93_RS05095	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6N93_RS05110	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6N93_RS05115	COG0765	amino acid transport
I6N93_RS05120	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6N93_RS05125	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I6N93_RS05130	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I6N93_RS05140	COG2233	PERMEase
I6N93_RS05145	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I6N93_RS05150	COG1393	Belongs to the ArsC family
I6N93_RS05155	COG4783	chaperone-mediated protein folding
I6N93_RS05160	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I6N93_RS05165	COG2716	regulation of RNA biosynthetic process
I6N93_RS05175	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
I6N93_RS05180	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
I6N93_RS05185	COG2707	UPF0756 membrane protein
I6N93_RS05190	COG1444	tRNA N-acetyltransferase activity
I6N93_RS05195	COG0400	carboxylic ester hydrolase activity
I6N93_RS05205	COG1876	peptidase activity
I6N93_RS05210	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6N93_RS05215	COG1393	Belongs to the ArsC family
I6N93_RS05225	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I6N93_RS05230	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6N93_RS05235	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6N93_RS05240	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I6N93_RS05245	COG0321	lipoyl(octanoyl) transferase activity
I6N93_RS05255	COG1686	Belongs to the peptidase S11 family
I6N93_RS05260	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I6N93_RS05265	COG0772	Belongs to the SEDS family
I6N93_RS05270	COG0768	penicillin binding
I6N93_RS05275	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
I6N93_RS05280	COG0799	negative regulation of ribosome biogenesis
I6N93_RS05285	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I6N93_RS05290	COG1466	dna polymerase III delta subunit
I6N93_RS05295	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
I6N93_RS05300	COG0495	leucyl-tRNA aminoacylation
I6N93_RS05305	COG2888	peptidyl-tyrosine sulfation
I6N93_RS05310	COG1126	abc transporter atp-binding protein
I6N93_RS05315	COG0765	amino acid transport
I6N93_RS05320	COG0765	amino acid transport
I6N93_RS05330	COG0815	Transfers the fatty acyl group on membrane lipoproteins
I6N93_RS05335	COG4535	Mg2 and Co2 transporter CorC
I6N93_RS05340	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
I6N93_RS05345	COG1702	phosphate starvation-inducible protein PhoH
I6N93_RS05350	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6N93_RS05355	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6N93_RS05360	COG2076	Multidrug Resistance protein
I6N93_RS05395	COG0367	asparagine synthase
I6N93_RS05400	COG1846	Transcriptional regulator
I6N93_RS05400	COG1940	carbohydrate kinase activity
I6N93_RS05405	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I6N93_RS05410	COG0363	glucosamine-6-phosphate deaminase activity
I6N93_RS05415	COG2190	(PTS) system
I6N93_RS05415	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6N93_RS05415	COG1263	PTS System
I6N93_RS05420	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6N93_RS05425	COG0735	belongs to the Fur family
I6N93_RS05430	COG0716	FMN binding
I6N93_RS05435	COG0840	transmembrane signaling receptor activity
I6N93_RS05445	COG0596	Alpha beta hydrolase
I6N93_RS05450	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
I6N93_RS05455	COG0033	Phosphoglucomutase
I6N93_RS05465	COG0745	RESPONSE REGULATOR receiver
I6N93_RS05470	COG2205	protein histidine kinase activity
I6N93_RS05480	COG3272	Protein of unknown function (DUF1722)
I6N93_RS05485	COG0415	Belongs to the DNA photolyase family
I6N93_RS05490	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6N93_RS05495	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I6N93_RS05500	COG1984	allophanate hydrolase subunit 2
I6N93_RS05505	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
I6N93_RS05510	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I6N93_RS05515	COG0372	Belongs to the citrate synthase family
I6N93_RS05525	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
I6N93_RS05530	COG1053	succinate dehydrogenase
I6N93_RS05535	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6N93_RS05540	COG0567	Dehydrogenase, E1 component
I6N93_RS05545	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6N93_RS05555	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I6N93_RS05560	COG1271	oxidase subunit
I6N93_RS05565	COG1294	oxidase, subunit
I6N93_RS05570	COG4890	Cyd operon protein YbgT
I6N93_RS05575	COG3790	cyd operon protein YbgE
I6N93_RS05580	COG0824	Thioesterase
I6N93_RS05585	COG0811	peptide transport
I6N93_RS05590	COG0848	biopolymer transport protein
I6N93_RS05595	COG3064	Membrane
I6N93_RS05595	COG3064	Membrane
I6N93_RS05600	COG0823	Involved in the tonB-independent uptake of proteins
I6N93_RS05605	COG2885	chlorophyll binding
I6N93_RS05610	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
I6N93_RS05635	COG1230	cation diffusion facilitator family transporter
I6N93_RS05640	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6N93_RS05650	COG2017	converts alpha-aldose to the beta-anomer
I6N93_RS05655	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6N93_RS05660	COG1119	ATPase activity
I6N93_RS05665	COG3585	molybdate ion transport
I6N93_RS05665	COG2005	Transcriptional regulator
I6N93_RS05675	COG0725	ABC transporter, periplasmic molybdate-binding protein
I6N93_RS05680	COG4149	molybdate abc transporter
I6N93_RS05685	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
I6N93_RS05690	COG0561	phosphatase activity
I6N93_RS05695	COG2706	6-phosphogluconolactonase activity
I6N93_RS05715	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6N93_RS05715	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6N93_RS05725	COG0572	uridine kinase
I6N93_RS05730	COG0717	Belongs to the dCTP deaminase family
I6N93_RS05735	COG2982	Protein involved in outer membrane biogenesis
I6N93_RS05740	COG1253	flavin adenine dinucleotide binding
I6N93_RS05755	COG3206	protein involved in exopolysaccharide biosynthesis
I6N93_RS05755	COG0489	protein tyrosine kinase activity
I6N93_RS05780	COG2244	polysaccharide biosynthetic process
I6N93_RS05785	COG0463	Glycosyl transferase, family 2
I6N93_RS05790	COG0438	transferase activity, transferring glycosyl groups
I6N93_RS05805	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6N93_RS05825	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6N93_RS05850	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6N93_RS05855	COG2990	Protein conserved in bacteria
I6N93_RS05860	COG3720	iron ion transport
I6N93_RS05865	COG4558	Periplasmic binding protein
I6N93_RS05870	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6N93_RS05875	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
I6N93_RS05885	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6N93_RS05890	COG2203	Gaf domain
I6N93_RS05890	COG3706	GGDEF domain
I6N93_RS05890	COG4251	negative regulation of phosphorylation
I6N93_RS05890	COG5001	Diguanylate cyclase
I6N93_RS05920	COG3008	intermembrane lipid transfer
I6N93_RS05925	COG2995	paraquat-inducible protein a
I6N93_RS05935	COG2197	response regulator
I6N93_RS05940	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6N93_RS05945	COG0436	Aminotransferase
I6N93_RS05955	COG1414	Transcriptional regulator
I6N93_RS05960	COG2375	cellular response to nickel ion
I6N93_RS05975	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6N93_RS05995	COG1811	Na channel or pump
I6N93_RS06000	COG0561	phosphatase activity
I6N93_RS06010	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6N93_RS06015	COG1733	regulation of RNA biosynthetic process
I6N93_RS06020	COG0702	epimerase
I6N93_RS06025	COG0604	alcohol dehydrogenase
I6N93_RS06025	COG1028	Short-chain dehydrogenase reductase Sdr
I6N93_RS06025	COG3321	synthase
I6N93_RS06035	COG3038	cytochrome b561
I6N93_RS06040	COG0484	heat shock protein binding
I6N93_RS06050	COG2217	Heavy metal translocating P-type atpase
I6N93_RS06060	COG1937	Protein conserved in bacteria
I6N93_RS06065	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
I6N93_RS06070	COG0784	Response regulator, receiver
I6N93_RS06070	COG0835	chemotaxis
I6N93_RS06095	COG0535	radical SAM domain protein
I6N93_RS06110	COG0673	inositol 2-dehydrogenase activity
I6N93_RS06140	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6N93_RS06145	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6N93_RS06155	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6N93_RS06155	COG2146	nitrite reductase [NAD(P)H] activity
I6N93_RS06160	COG0243	molybdopterin cofactor binding
I6N93_RS06165	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6N93_RS06165	COG1648	precorrin-2 dehydrogenase activity
I6N93_RS06175	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6N93_RS06180	COG0765	amino acid transport
I6N93_RS06185	COG0765	amino acid transport
I6N93_RS06195	COG0436	Aminotransferase
I6N93_RS06205	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6N93_RS06240	COG2853	Lipoprotein
I6N93_RS06280	COG2198	Histidine kinase
I6N93_RS06280	COG0643	Histidine kinase
I6N93_RS06285	COG0835	chemotaxis
I6N93_RS06290	COG0840	transmembrane signaling receptor activity
I6N93_RS06295	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
I6N93_RS06300	COG2201	protein-glutamate methylesterase activity
I6N93_RS06305	COG0745	RESPONSE REGULATOR receiver
I6N93_RS06315	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I6N93_RS06320	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I6N93_RS06330	COG3418	PFAM FlgN family protein
I6N93_RS06335	COG2747	anti-sigma28 factor FlgM
I6N93_RS06345	COG1815	bacterial-type flagellum-dependent cell motility
I6N93_RS06350	COG1558	bacterial-type flagellum-dependent cell motility
I6N93_RS06355	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
I6N93_RS06360	COG1749	Flagellar hook protein flgE
I6N93_RS06380	COG1706	bacterial-type flagellum-dependent cell motility
I6N93_RS06390	COG1256	bacterial-type flagellum assembly
I6N93_RS06400	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
I6N93_RS06415	COG1677	Flagellar hook-basal body complex protein FliE
I6N93_RS06425	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I6N93_RS06430	COG1317	bacterial-type flagellum organization
I6N93_RS06445	COG3144	bacterial-type flagellum assembly
I6N93_RS06450	COG1580	Controls the rotational direction of flagella during chemotaxis
I6N93_RS06455	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I6N93_RS06490	COG0438	transferase activity, transferring glycosyl groups
I6N93_RS06490	COG1216	Glycosyl transferase, family 2
I6N93_RS06505	COG1191	sigma factor activity
I6N93_RS06515	COG1702	phosphate starvation-inducible protein PhoH
I6N93_RS06535	COG1067	ATP-dependent peptidase activity
I6N93_RS06570	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
I6N93_RS06575	COG2943	transferase activity, transferring hexosyl groups
I6N93_RS06580	COG1560	Kdo2-lipid A biosynthetic process
I6N93_RS06585	COG1054	Belongs to the UPF0176 family
I6N93_RS06595	COG3038	cytochrome b561
I6N93_RS06610	COG0418	dihydroorotase activity
I6N93_RS06620	COG1530	ribonuclease E activity
I6N93_RS06625	COG0564	pseudouridine synthase activity
I6N93_RS06635	COG1399	metal-binding, possibly nucleic acid-binding protein
I6N93_RS06640	COG0333	Belongs to the bacterial ribosomal protein bL32 family
I6N93_RS06645	COG0416	fatty acid biosynthetic process
I6N93_RS06650	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6N93_RS06665	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6N93_RS06670	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6N93_RS06675	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6N93_RS06680	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I6N93_RS06685	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I6N93_RS06690	COG0470	DNA polymerase III
I6N93_RS06695	COG0084	hydrolase, TatD family'
I6N93_RS06700	COG1263	PTS System
I6N93_RS06700	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6N93_RS06705	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
I6N93_RS06710	COG0537	adenosine 5'-monophosphoramidase activity
I6N93_RS06715	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
I6N93_RS06725	COG1472	Belongs to the glycosyl hydrolase 3 family
I6N93_RS06730	COG1252	NADH dehydrogenase
I6N93_RS06735	COG3134	Outer membrane lipoprotein
I6N93_RS06745	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6N93_RS06750	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6N93_RS06755	COG1136	(ABC) transporter
I6N93_RS06760	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6N93_RS06775	COG0791	NLP P60 protein
I6N93_RS06785	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
I6N93_RS06790	COG2989	Protein conserved in bacteria
I6N93_RS06795	COG3108	Peptidase M15
I6N93_RS06800	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6N93_RS06805	COG1448	Aminotransferase
I6N93_RS06815	COG0017	Asparaginyl-tRNA synthetase
I6N93_RS06820	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I6N93_RS06830	COG0308	aminopeptidase N
I6N93_RS06835	COG1116	anion transmembrane transporter activity
I6N93_RS06840	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6N93_RS06845	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6N93_RS06850	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6N93_RS06855	COG0431	NADPH-dependent FMN reductase
I6N93_RS06860	COG0167	dihydroorotate dehydrogenase activity
I6N93_RS06870	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I6N93_RS06870	COG0116	Belongs to the methyltransferase superfamily
I6N93_RS06875	COG0488	(ABC) transporter
I6N93_RS06880	COG2995	paraquat-inducible protein a
I6N93_RS06885	COG3008	intermembrane lipid transfer
I6N93_RS06885	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6N93_RS06890	COG3009	Protein conserved in bacteria
I6N93_RS06895	COG3130	regulation of translation
I6N93_RS06905	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
I6N93_RS06910	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6N93_RS06910	COG0574	Belongs to the PEP-utilizing enzyme family
I6N93_RS06920	COG0628	permease
I6N93_RS06925	COG0247	lactate metabolic process
I6N93_RS06925	COG0277	FAD linked oxidase domain protein
I6N93_RS06930	COG2050	protein possibly involved in aromatic compounds catabolism
I6N93_RS06940	COG0316	Belongs to the HesB IscA family
I6N93_RS06945	COG0719	Fe-S assembly protein
I6N93_RS06950	COG0396	ATPase activity
I6N93_RS06955	COG0719	Fe-S assembly protein
I6N93_RS06960	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6N93_RS06965	COG2166	iron-sulfur cluster assembly
I6N93_RS06970	COG1376	ErfK ybiS ycfS ynhG family protein
I6N93_RS06970	COG1388	LysM domain
I6N93_RS06975	COG4238	major outer membrane lipoprotein
I6N93_RS07015	COG2197	response regulator
I6N93_RS07020	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6N93_RS07030	COG1294	oxidase, subunit
I6N93_RS07035	COG1271	oxidase subunit
I6N93_RS07040	COG0477	Major facilitator Superfamily
I6N93_RS07060	COG0512	Glutamine amidotransferase of anthranilate synthase
I6N93_RS07060	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I6N93_RS07070	COG0583	DNA-binding transcription factor activity
I6N93_RS07080	COG1028	Short-chain dehydrogenase reductase Sdr
I6N93_RS07085	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I6N93_RS07090	COG1012	belongs to the aldehyde dehydrogenase family
I6N93_RS07100	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6N93_RS07110	COG0534	Mate efflux family protein
I6N93_RS07115	COG0307	riboflavin synthase, alpha
I6N93_RS07120	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6N93_RS07125	COG1609	Transcriptional regulator
I6N93_RS07145	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
I6N93_RS07150	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6N93_RS07160	COG3313	Fe-S protein
I6N93_RS07175	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
I6N93_RS07180	COG3895	Periplasmic Protein
I6N93_RS07185	COG0259	pyridoxamine-phosphate oxidase activity
I6N93_RS07190	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I6N93_RS07195	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
I6N93_RS07215	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6N93_RS07220	COG0671	phosphoesterase, PA-phosphatase related
I6N93_RS07225	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
I6N93_RS07230	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
I6N93_RS07235	COG0284	orotidine-5'-phosphate decarboxylase activity
I6N93_RS07240	COG0023	Translation Initiation Factor
I6N93_RS07250	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
I6N93_RS07255	COG0243	molybdopterin cofactor binding
I6N93_RS07265	COG1486	melibiose metabolic process
I6N93_RS07270	COG2188	Transcriptional regulator
I6N93_RS07275	COG0583	DNA-binding transcription factor activity
I6N93_RS07280	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I6N93_RS07300	COG4168	peptide transport system, permease
I6N93_RS07305	COG4166	transmembrane transport
I6N93_RS07310	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I6N93_RS07315	COG1842	Phage shock protein A
I6N93_RS07325	COG1983	PspC domain protein
I6N93_RS07330	COG3106	COG3106 Predicted ATPase
I6N93_RS07335	COG3768	UPF0283 membrane protein
I6N93_RS07340	COG2807	transmembrane transport
I6N93_RS07365	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
I6N93_RS07375	COG0598	Magnesium transport protein CorA
I6N93_RS07380	COG0037	tRNA processing
I6N93_RS07390	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6N93_RS07395	COG2911	Protein conserved in bacteria
I6N93_RS07405	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I6N93_RS07410	COG1643	Atp-dependent helicase
I6N93_RS07425	COG3591	Belongs to the peptidase S1B family
I6N93_RS07435	COG2205	protein histidine kinase activity
I6N93_RS07440	COG0745	RESPONSE REGULATOR receiver
I6N93_RS07445	COG0659	secondary active sulfate transmembrane transporter activity
I6N93_RS07450	COG0387	Pfam Sodium calcium exchanger
I6N93_RS07455	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
I6N93_RS07470	COG2261	transglycosylase associated protein
I6N93_RS07475	COG1454	alcohol dehydrogenase
I6N93_RS07480	COG3842	ATPase activity
I6N93_RS07490	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6N93_RS07495	COG1012	belongs to the aldehyde dehydrogenase family
I6N93_RS07505	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6N93_RS07510	COG0395	ABC-type sugar transport system, permease component
I6N93_RS07515	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I6N93_RS07525	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
I6N93_RS07530	COG4792	protein secretion
I6N93_RS07540	COG4794	Type iii secretion
I6N93_RS07595	COG2197	response regulator
I6N93_RS07615	COG4669	(LipO)protein
I6N93_RS07665	COG0583	DNA-binding transcription factor activity
I6N93_RS07670	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I6N93_RS07675	COG4658	electron transport chain
I6N93_RS07680	COG4656	Part of a membrane complex involved in electron transport
I6N93_RS07690	COG2723	6-phospho-beta-galactosidase activity
I6N93_RS07695	COG0673	inositol 2-dehydrogenase activity
I6N93_RS07700	COG0385	Bile acid
I6N93_RS07705	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I6N93_RS07710	COG5339	Protein conserved in bacteria
I6N93_RS07715	COG1482	cell wall glycoprotein biosynthetic process
I6N93_RS07720	COG0114	fumarate hydratase activity
I6N93_RS07730	COG2814	Major facilitator Superfamily
I6N93_RS07735	COG0583	DNA-binding transcription factor activity
I6N93_RS07740	COG1940	carbohydrate kinase activity
I6N93_RS07745	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
I6N93_RS07750	COG3459	Glycosyltransferase 36 associated
I6N93_RS07770	COG4221	oxidoreductase activity
I6N93_RS07780	COG1215	transferase activity, transferring glycosyl groups
I6N93_RS07790	COG2066	Belongs to the glutaminase family
I6N93_RS07795	COG4305	rare lipoprotein A
I6N93_RS07805	COG0840	transmembrane signaling receptor activity
I6N93_RS07810	COG1764	response to oxidative stress
I6N93_RS07815	COG1902	pentaerythritol trinitrate reductase activity
I6N93_RS07820	COG4221	oxidoreductase activity
I6N93_RS07860	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6N93_RS07870	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
I6N93_RS07875	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
I6N93_RS07885	COG2877	3-deoxy-8-phosphooctulonate synthase activity
I6N93_RS07890	COG2912	Transglutaminase-like superfamily
I6N93_RS07900	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I6N93_RS07905	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
I6N93_RS07910	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
I6N93_RS07915	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
I6N93_RS07930	COG0193	aminoacyl-tRNA hydrolase activity
I6N93_RS07935	COG0012	GTP binding
I6N93_RS07940	COG0789	Transcriptional regulator
I6N93_RS07955	COG0583	DNA-binding transcription factor activity
I6N93_RS07965	COG2200	EAL domain
I6N93_RS07965	COG2202	Pas domain
I6N93_RS07965	COG2199	diguanylate cyclase activity
I6N93_RS07970	COG0277	FAD linked oxidase domain protein
I6N93_RS07975	COG1283	sodium-dependent phosphate transmembrane transporter activity
I6N93_RS07990	COG4149	molybdate abc transporter
I6N93_RS08005	COG2188	Transcriptional regulator
I6N93_RS08020	COG5297	Belongs to the glycosyl hydrolase family 6
I6N93_RS08040	COG0616	signal peptide processing
I6N93_RS08045	COG1028	Short-chain dehydrogenase reductase Sdr
I6N93_RS08050	COG1187	pseudouridine synthase activity
I6N93_RS08055	COG0009	L-threonylcarbamoyladenylate synthase
I6N93_RS08060	COG0613	PHP domain protein
I6N93_RS08070	COG0512	Glutamine amidotransferase of anthranilate synthase
I6N93_RS08075	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6N93_RS08080	COG0134	indole-3-glycerol-phosphate synthase activity
I6N93_RS08080	COG0135	phosphoribosylanthranilate isomerase activity
I6N93_RS08085	COG0133	tryptophan synthase activity
I6N93_RS08090	COG0159	tryptophan synthase activity
I6N93_RS08095	COG0727	PFAM Uncharacterised protein family (UPF0153)
I6N93_RS08105	COG2917	probably involved in intracellular septation
I6N93_RS08120	COG2350	Protein conserved in bacteria
I6N93_RS08130	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6N93_RS08145	COG0444	Belongs to the ABC transporter superfamily
I6N93_RS08150	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6N93_RS08155	COG0601	transmembrane transport
I6N93_RS08165	COG2095	MarC family integral membrane protein
I6N93_RS08170	COG1454	alcohol dehydrogenase
I6N93_RS08170	COG1012	belongs to the aldehyde dehydrogenase family
I6N93_RS08190	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6N93_RS08195	COG0745	RESPONSE REGULATOR receiver
I6N93_RS08200	COG1752	Esterase of the alpha-beta hydrolase superfamily
I6N93_RS08205	COG3012	SEC-C Motif Domain Protein
I6N93_RS08210	COG0788	formyltetrahydrofolate deformylase activity
I6N93_RS08225	COG2860	membrane
I6N93_RS08230	COG0708	Exodeoxyribonuclease III
I6N93_RS08245	COG0778	Nitroreductase
I6N93_RS08250	COG0616	signal peptide processing
I6N93_RS08255	COG0252	asparaginase activity
I6N93_RS08260	COG1335	isochorismatase
I6N93_RS08265	COG3139	Protein of unknown function (DUF1315)
I6N93_RS08270	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6N93_RS08285	COG3713	MltA-interacting MipA family protein
I6N93_RS08290	COG2766	serine protein kinase
I6N93_RS08295	COG2718	Belongs to the UPF0229 family
I6N93_RS08300	COG2719	SpoVR family
I6N93_RS08305	COG2186	Transcriptional regulator
I6N93_RS08310	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
I6N93_RS08325	COG2983	Belongs to the UPF0260 family
I6N93_RS08330	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6N93_RS08340	COG0850	regulation of cytokinetic process
I6N93_RS08345	COG2894	cell division
I6N93_RS08350	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
I6N93_RS08355	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
I6N93_RS08360	COG0318	PFAM AMP-dependent synthetase and ligase
I6N93_RS08365	COG3065	identical protein binding
I6N93_RS08375	COG1199	ATP-dependent helicase activity
I6N93_RS08395	COG1760	l-serine dehydratase
I6N93_RS08400	COG1253	flavin adenine dinucleotide binding
I6N93_RS08405	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6N93_RS08405	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6N93_RS08410	COG3715	PTS system
I6N93_RS08415	COG3716	PTS system mannose fructose sorbose family IID component
I6N93_RS08420	COG4811	Protein of unknown function (DUF986)
I6N93_RS08425	COG1971	Probably functions as a manganese efflux pump
I6N93_RS08430	COG2226	methyltransferase
I6N93_RS08450	COG3001	Fructosamine kinase
I6N93_RS08460	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6N93_RS08470	COG1988	membrane-bound metal-dependent
I6N93_RS08475	COG1823	symporter activity
I6N93_RS08480	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6N93_RS08485	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I6N93_RS08500	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6N93_RS08500	COG0072	phenylalanine-tRNA ligase activity
I6N93_RS08505	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
I6N93_RS08525	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
I6N93_RS08530	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I6N93_RS08540	COG0501	Belongs to the peptidase M48B family
I6N93_RS08550	COG0538	isocitrate dehydrogenase activity
I6N93_RS08555	COG1187	pseudouridine synthase activity
I6N93_RS08565	COG0482	sulfurtransferase activity
I6N93_RS08570	COG2915	High frequency lysogenization protein hflD homolog
I6N93_RS08575	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I6N93_RS08580	COG0745	RESPONSE REGULATOR receiver
I6N93_RS08585	COG2205	protein histidine kinase activity
I6N93_RS08590	COG2850	peptidyl-arginine hydroxylation
I6N93_RS08595	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6N93_RS08620	COG0793	Belongs to the peptidase S41A family
I6N93_RS08625	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
I6N93_RS08630	COG1956	GAF domain-containing protein
I6N93_RS08635	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6N93_RS08635	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
I6N93_RS08665	COG0402	S-adenosylhomocysteine deaminase activity
I6N93_RS08700	COG4104	PAAR repeat-containing protein
I6N93_RS08710	COG1528	Iron-storage protein
I6N93_RS08720	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
I6N93_RS08725	COG0800	Aldolase
I6N93_RS08730	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I6N93_RS08735	COG1737	Transcriptional regulator
I6N93_RS08740	COG0469	pyruvate kinase activity
I6N93_RS08750	COG1560	Kdo2-lipid A biosynthetic process
I6N93_RS08755	COG0739	heme binding
I6N93_RS08760	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
I6N93_RS08765	COG1121	(ABC) transporter
I6N93_RS08770	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6N93_RS08775	COG2255	four-way junction helicase activity
I6N93_RS08780	COG0632	four-way junction helicase activity
I6N93_RS08790	COG0217	transcriptional regulatory protein
I6N93_RS08795	COG0494	nUDIX hydrolase
I6N93_RS08800	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I6N93_RS08805	COG1335	isochorismatase
I6N93_RS08810	COG1801	Protein of unknown function DUF72
I6N93_RS08815	COG3788	relative of glutathione S-transferase, MAPEG superfamily
I6N93_RS08820	COG2226	methyltransferase
I6N93_RS08825	COG0500	methyltransferase
I6N93_RS08845	COG3142	Participates in the control of copper homeostasis
I6N93_RS08850	COG3102	Protein conserved in bacteria
I6N93_RS08855	COG0018	arginyl-trna synthetase
I6N93_RS08865	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6N93_RS08870	COG0477	Major facilitator Superfamily
I6N93_RS08875	COG2999	glutathione oxidoreductase activity
I6N93_RS08885	COG3381	protein complex oligomerization
I6N93_RS08920	COG1966	Carbon starvation protein
I6N93_RS08925	COG2879	small protein
I6N93_RS08930	COG0523	cobalamin synthesis protein
I6N93_RS08935	COG3279	Response regulator of the LytR AlgR family
I6N93_RS08940	COG3275	phosphorelay sensor kinase activity
I6N93_RS08945	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
I6N93_RS08950	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
I6N93_RS08955	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
I6N93_RS08960	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6N93_RS08965	COG1434	Gram-negative-bacterium-type cell wall biogenesis
I6N93_RS08970	COG3173	Aminoglycoside phosphotransferase
I6N93_RS08980	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
I6N93_RS08985	COG2835	tetraacyldisaccharide 4'-kinase activity
I6N93_RS08990	COG1663	tetraacyldisaccharide 4'-kinase activity
I6N93_RS08995	COG1132	(ABC) transporter
I6N93_RS09000	COG0658	competence protein
I6N93_RS09000	COG2333	competence protein COMEC
I6N93_RS09005	COG2926	Belongs to the UPF0265 family
I6N93_RS09020	COG2925	Exonuclease
I6N93_RS09025	COG0640	Transcriptional regulator
I6N93_RS09035	COG0531	amino acid
I6N93_RS09040	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
I6N93_RS09045	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
I6N93_RS09065	COG3052	prosthetic group binding
I6N93_RS09070	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
I6N93_RS09075	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6N93_RS09095	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6N93_RS09100	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I6N93_RS09105	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I6N93_RS09110	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6N93_RS09115	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I6N93_RS09115	COG0131	Imidazoleglycerol-phosphate dehydratase
I6N93_RS09120	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I6N93_RS09125	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
I6N93_RS09135	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
I6N93_RS09135	COG0140	phosphoribosyl-ATP diphosphatase activity
I6N93_RS09140	COG0776	regulation of translation
I6N93_RS09145	COG0539	negative regulation of cytoplasmic translation
I6N93_RS09150	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I6N93_RS09155	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I6N93_RS09160	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
I6N93_RS09165	COG1944	ATP diphosphatase activity
I6N93_RS09170	COG2116	formate transmembrane transporter activity
I6N93_RS09175	COG1882	Formate acetyltransferase
I6N93_RS09180	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6N93_RS09185	COG2814	Major facilitator Superfamily
I6N93_RS09190	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I6N93_RS09195	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6N93_RS09200	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
I6N93_RS09205	COG3107	peptidoglycan biosynthetic process
I6N93_RS09205	COG1674	ftsk spoiiie
I6N93_RS09210	COG1522	sequence-specific DNA binding
I6N93_RS09215	COG0492	ferredoxin-NADP+ reductase activity
I6N93_RS09220	COG4988	ABC transporter
I6N93_RS09225	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I6N93_RS09230	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
I6N93_RS09235	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I6N93_RS09245	COG0542	response to heat
I6N93_RS09250	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
I6N93_RS09255	COG1278	Cold shock
I6N93_RS09260	COG3593	DNA synthesis involved in DNA repair
I6N93_RS09260	COG3593	DNA synthesis involved in DNA repair
I6N93_RS09265	COG2431	L-lysine efflux transmembrane transporter activity
I6N93_RS09270	COG3023	N-Acetylmuramoyl-L-alanine amidase
I6N93_RS09275	COG0393	Putative heavy-metal-binding
I6N93_RS09280	COG1126	abc transporter atp-binding protein
I6N93_RS09285	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6N93_RS09290	COG4215	(ABC) transporter
I6N93_RS09295	COG4160	amino acid transport
I6N93_RS09300	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6N93_RS09305	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6N93_RS09315	COG1177	transmembrane transport
I6N93_RS09320	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6N93_RS09325	COG3842	ATPase activity
I6N93_RS09330	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I6N93_RS09355	COG2985	domain, Protein
I6N93_RS09355	COG0569	domain protein
I6N93_RS09360	COG1349	DNA-binding transcription factor activity
I6N93_RS09365	COG1686	Belongs to the peptidase S11 family
I6N93_RS09370	COG2011	ABC-type metal ion transport system permease component
I6N93_RS09375	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6N93_RS09390	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6N93_RS09395	COG2949	membrane
I6N93_RS09400	COG2311	Membrane
I6N93_RS09405	COG0302	gtp cyclohydrolase
I6N93_RS09410	COG0840	transmembrane signaling receptor activity
I6N93_RS09415	COG0840	transmembrane signaling receptor activity
I6N93_RS09435	COG0583	DNA-binding transcription factor activity
I6N93_RS09455	COG0371	Dehydrogenase
I6N93_RS09460	COG1129	ABC transporter
I6N93_RS09465	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6N93_RS09475	COG0833	amino acid
I6N93_RS09480	COG0583	DNA-binding transcription factor activity
I6N93_RS09485	COG2855	membrane
I6N93_RS09490	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
I6N93_RS09495	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6N93_RS09495	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
I6N93_RS09495	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6N93_RS09500	COG1105	Belongs to the carbohydrate kinase PfkB family
I6N93_RS09505	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6N93_RS09505	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6N93_RS09520	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I6N93_RS09530	COG0671	phosphoesterase, PA-phosphatase related
I6N93_RS09535	COG0791	NLP P60 protein
I6N93_RS09540	COG4166	transmembrane transport
I6N93_RS09545	COG4174	ABC transporter (Permease)
I6N93_RS09550	COG4239	(ABC) transporter, permease
I6N93_RS09555	COG4172	Belongs to the ABC transporter superfamily
I6N93_RS09565	COG2814	Major facilitator Superfamily
I6N93_RS09580	COG1061	Type III restriction enzyme res subunit
I6N93_RS09585	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
I6N93_RS09590	COG2223	nitrite transmembrane transporter activity
I6N93_RS09595	COG3279	Response regulator of the LytR AlgR family
I6N93_RS09600	COG3275	phosphorelay sensor kinase activity
I6N93_RS09605	COG3081	Nucleoid-associated protein
I6N93_RS09610	COG3082	Protein of unknown function (DUF1414)
I6N93_RS09615	COG3083	sulfuric ester hydrolase activity
I6N93_RS09630	COG3122	Protein conserved in bacteria
I6N93_RS09640	COG1278	Cold shock
I6N93_RS09645	COG3136	membrane protein required for alginate biosynthesis
I6N93_RS09650	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6N93_RS09655	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
I6N93_RS09660	COG0783	Belongs to the Dps family
I6N93_RS09665	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6N93_RS09670	COG0765	amino acid transport
I6N93_RS09675	COG1126	abc transporter atp-binding protein
I6N93_RS09680	COG0671	phosphoesterase, PA-phosphatase related
I6N93_RS09690	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6N93_RS09705	COG1472	Belongs to the glycosyl hydrolase 3 family
I6N93_RS09715	COG1349	DNA-binding transcription factor activity
I6N93_RS09725	COG1686	Belongs to the peptidase S11 family
I6N93_RS09730	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I6N93_RS09740	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6N93_RS09755	COG0513	Belongs to the DEAD box helicase family
I6N93_RS09765	COG0392	lysyltransferase activity
I6N93_RS09770	COG0670	Belongs to the BI1 family
I6N93_RS09775	COG0314	molybdopterin synthase activity
I6N93_RS09780	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
I6N93_RS09790	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6N93_RS09795	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I6N93_RS09800	COG0391	Required for morphogenesis under gluconeogenic growth conditions
I6N93_RS09805	COG0556	nucleotide-excision repair
I6N93_RS09815	COG2226	methyltransferase
I6N93_RS09820	COG0156	8-amino-7-oxononanoate synthase activity
I6N93_RS09825	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I6N93_RS09835	COG1380	Effector of murein hydrolase LrgA
I6N93_RS09840	COG1346	cytolysis
I6N93_RS09845	COG0295	cytidine deaminase activity
I6N93_RS09850	COG0281	malic enzyme
I6N93_RS09855	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6N93_RS09860	COG0601	transmembrane transport
I6N93_RS09865	COG0747	negative chemotaxis
I6N93_RS09870	COG4172	Belongs to the ABC transporter superfamily
I6N93_RS09875	COG0303	'Molybdopterin
I6N93_RS09900	COG0401	homolog of Blt101
I6N93_RS09915	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I6N93_RS09925	COG4172	Belongs to the ABC transporter superfamily
I6N93_RS09930	COG0405	Gamma-glutamyltransferase
I6N93_RS09935	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6N93_RS09950	COG2186	Transcriptional regulator
I6N93_RS09960	COG1984	allophanate hydrolase subunit 2
I6N93_RS09970	COG0439	Biotin carboxylase
I6N93_RS09975	COG0511	ligase activity, forming carbon-carbon bonds
I6N93_RS09990	COG0028	Belongs to the TPP enzyme family
I6N93_RS09995	COG0745	RESPONSE REGULATOR receiver
I6N93_RS10000	COG2205	protein histidine kinase activity
I6N93_RS10005	COG4771	TonB-dependent receptor
I6N93_RS10025	COG3228	Belongs to the MtfA family
I6N93_RS10040	COG4943	cyclic-guanylate-specific phosphodiesterase activity
I6N93_RS10045	COG1560	Kdo2-lipid A biosynthetic process
I6N93_RS10060	COG1309	transcriptional regulator
I6N93_RS10065	COG0588	phosphoglycerate mutase activity
I6N93_RS10080	COG4608	Belongs to the ABC transporter superfamily
I6N93_RS10085	COG0444	Belongs to the ABC transporter superfamily
I6N93_RS10090	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6N93_RS10095	COG0601	transmembrane transport
I6N93_RS10105	COG2267	carboxylic ester hydrolase activity
I6N93_RS10110	COG1012	belongs to the aldehyde dehydrogenase family
I6N93_RS10115	COG1177	transmembrane transport
I6N93_RS10120	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6N93_RS10125	COG3842	ATPase activity
I6N93_RS10130	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I6N93_RS10140	COG0583	DNA-binding transcription factor activity
I6N93_RS10155	COG1280	lysine exporter protein (LysE YggA)
I6N93_RS10160	COG0531	amino acid
I6N93_RS10165	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I6N93_RS10170	COG0531	amino acid
I6N93_RS10175	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I6N93_RS10180	COG1120	ATPase activity
I6N93_RS10185	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6N93_RS10190	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6N93_RS10195	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6N93_RS10200	COG4264	IucA IucC family
I6N93_RS10210	COG4264	IucA IucC family
I6N93_RS10215	COG2814	Major facilitator Superfamily
I6N93_RS10220	COG0019	diaminopimelate decarboxylase activity
I6N93_RS10225	COG4264	IucA IucC family
I6N93_RS10235	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6N93_RS10240	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6N93_RS10245	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I6N93_RS10250	COG1301	dicarboxylic acid transport
I6N93_RS10255	COG0583	DNA-binding transcription factor activity
I6N93_RS10265	COG3383	formate dehydrogenase (NAD+) activity
I6N93_RS10270	COG1301	dicarboxylic acid transport
I6N93_RS10280	COG0582	viral genome integration into host DNA
I6N93_RS10325	COG3501	Rhs element vgr protein
I6N93_RS10335	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6N93_RS10350	COG0673	inositol 2-dehydrogenase activity
I6N93_RS10355	COG0673	inositol 2-dehydrogenase activity
I6N93_RS10365	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6N93_RS10370	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6N93_RS10380	COG1349	DNA-binding transcription factor activity
I6N93_RS10415	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6N93_RS10420	COG0322	excinuclease ABC activity
I6N93_RS10425	COG2197	response regulator
I6N93_RS10440	COG1113	amino acid transport
I6N93_RS10455	COG0582	viral genome integration into host DNA
I6N93_RS10470	COG3423	Transcriptional regulator
I6N93_RS10490	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I6N93_RS10560	COG3736	Type IV secretory pathway, component VirB8
I6N93_RS10565	COG3504	Conjugal transfer protein
I6N93_RS10575	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
I6N93_RS10675	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I6N93_RS10680	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6N93_RS10690	COG0402	S-adenosylhomocysteine deaminase activity
I6N93_RS10695	COG0493	'glutamate synthase
I6N93_RS10695	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6N93_RS10700	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
I6N93_RS10700	COG3608	succinylglutamate desuccinylase aspartoacylase
I6N93_RS10710	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6N93_RS10715	COG3829	transcription factor binding
I6N93_RS10720	COG2068	MobA-Related Protein
I6N93_RS10730	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6N93_RS10745	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6N93_RS10755	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6N93_RS10765	COG1028	Short-chain dehydrogenase reductase Sdr
I6N93_RS10770	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6N93_RS10790	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6N93_RS10795	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6N93_RS10805	COG1064	alcohol dehydrogenase
I6N93_RS10810	COG2194	sulfuric ester hydrolase activity
I6N93_RS10835	COG1215	transferase activity, transferring glycosyl groups
I6N93_RS10840	COG1215	transferase activity, transferring glycosyl groups
I6N93_RS10845	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
I6N93_RS10850	COG0457	Tetratricopeptide repeat
I6N93_RS10850	COG3118	belongs to the thioredoxin family
I6N93_RS10855	COG2200	EAL domain
I6N93_RS10860	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6N93_RS10865	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
I6N93_RS10895	COG2814	Major facilitator Superfamily
I6N93_RS10900	COG3058	Necessary for formate dehydrogenase activity
I6N93_RS10910	COG0519	Catalyzes the synthesis of GMP from XMP
I6N93_RS10910	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6N93_RS10915	COG0488	(ABC) transporter
I6N93_RS10920	COG0384	phenazine biosynthesis protein PhzF
I6N93_RS10925	COG4575	ribosome binding
I6N93_RS10930	COG1007	ATP synthesis coupled electron transport
I6N93_RS10935	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6N93_RS10940	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6N93_RS10945	COG0713	ATP synthesis coupled electron transport
I6N93_RS10950	COG0839	Belongs to the complex I subunit 6 family
I6N93_RS10955	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6N93_RS10960	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
I6N93_RS10970	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
I6N93_RS10975	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
I6N93_RS10980	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6N93_RS10980	COG0649	NAD binding
I6N93_RS10990	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6N93_RS10995	COG0583	DNA-binding transcription factor activity
I6N93_RS11000	COG0436	Aminotransferase
I6N93_RS11005	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
I6N93_RS11010	COG0471	metal ion transport
I6N93_RS11010	COG0490	domain, Protein
I6N93_RS11015	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6N93_RS11025	COG3092	negative regulation of chromosome organization
I6N93_RS11030	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6N93_RS11035	COG0857	belongs to the CobB CobQ family
I6N93_RS11035	COG0280	phosphate acetyltransferase
I6N93_RS11045	COG0622	Phosphoesterase
I6N93_RS11050	COG1090	epimerase
I6N93_RS11055	COG4598	ABC transporter
I6N93_RS11065	COG4215	(ABC) transporter
I6N93_RS11075	COG0163	prenyltransferase activity
I6N93_RS11080	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
I6N93_RS11085	COG1286	toxin biosynthetic process
I6N93_RS11090	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
I6N93_RS11095	COG0285	dihydrofolate synthase activity
I6N93_RS11100	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
I6N93_RS11105	COG0586	Pfam SNARE associated Golgi protein
I6N93_RS11110	COG0101	tRNA pseudouridine synthase activity
I6N93_RS11115	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6N93_RS11120	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6N93_RS11130	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6N93_RS11135	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6N93_RS11135	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
I6N93_RS11150	COG3101	peptidyl-lysine hydroxylation
I6N93_RS11155	COG0730	response to heat
I6N93_RS11160	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
I6N93_RS11165	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
I6N93_RS11170	COG2890	protein-(glutamine-N5) methyltransferase activity
I6N93_RS11175	COG2840	Smr protein MutS2
I6N93_RS11180	COG2062	phosphohistidine phosphatase, SixA
I6N93_RS11185	COG3691	Protein conserved in bacteria
I6N93_RS11195	COG0579	oxidoreductase
I6N93_RS11205	COG2116	formate transmembrane transporter activity
I6N93_RS11220	COG2999	glutathione oxidoreductase activity
I6N93_RS11230	COG2259	Doxx family
I6N93_RS11235	COG0400	carboxylic ester hydrolase activity
I6N93_RS11240	COG4592	Periplasmic binding protein
I6N93_RS11250	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6N93_RS11255	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6N93_RS11260	COG1120	ATPase activity
I6N93_RS11275	COG2382	esterase
I6N93_RS11280	COG4774	siderophore transport
I6N93_RS11285	COG1169	isochorismate synthase
I6N93_RS11290	COG1021	2,3-dihydroxybenzoate-AMP ligase
I6N93_RS11295	COG3433	isochorismatase activity
I6N93_RS11295	COG1535	isochorismatase
I6N93_RS11300	COG1028	Short-chain dehydrogenase reductase Sdr
I6N93_RS11315	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6N93_RS11380	COG3266	domain, Protein
I6N93_RS11390	COG0436	Aminotransferase
I6N93_RS11400	COG4948	Mandelate Racemase Muconate Lactonizing
I6N93_RS11405	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6N93_RS11410	COG1196	nuclear chromosome segregation
I6N93_RS11410	COG3264	Mechanosensitive ion channel
I6N93_RS11420	COG3727	T/G mismatch-specific endonuclease activity
I6N93_RS11460	COG1522	sequence-specific DNA binding
I6N93_RS11480	COG4608	Belongs to the ABC transporter superfamily
I6N93_RS11485	COG0444	Belongs to the ABC transporter superfamily
I6N93_RS11490	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6N93_RS11495	COG0601	transmembrane transport
I6N93_RS11500	COG0747	negative chemotaxis
I6N93_RS11515	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I6N93_RS11520	COG2501	S4 domain
I6N93_RS11535	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6N93_RS11540	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6N93_RS11545	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I6N93_RS11550	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I6N93_RS11555	COG0814	amino acid
I6N93_RS11570	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I6N93_RS11575	COG0589	response to stress
I6N93_RS11600	COG0670	Belongs to the BI1 family
I6N93_RS11605	COG2920	part of a sulfur-relay system
I6N93_RS11610	COG1254	Belongs to the acylphosphatase family
I6N93_RS11615	COG3785	DNA binding
I6N93_RS11620	COG1832	CoA-binding protein
I6N93_RS11625	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
I6N93_RS11630	COG1803	Methylglyoxal synthase
I6N93_RS11635	COG0210	DNA helicase
I6N93_RS11640	COG3304	Inner membrane component domain
I6N93_RS11645	COG1289	transmembrane transporter activity
I6N93_RS11650	COG3070	regulator of competence-specific genes
I6N93_RS11655	COG5404	Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division
I6N93_RS11660	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
I6N93_RS11660	COG2885	chlorophyll binding
I6N93_RS11665	COG0667	Aldo Keto reductase
I6N93_RS11670	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6N93_RS11675	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6N93_RS11680	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6N93_RS11685	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6N93_RS11690	COG0435	Glutathione S-transferase
I6N93_RS11695	COG0826	peptidase U32
I6N93_RS11700	COG1597	lipid kinase activity
I6N93_RS11705	COG3223	Belongs to the PsiE family
I6N93_RS11715	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
I6N93_RS11720	COG3722	fumarate hydratase activity
I6N93_RS11725	COG0246	Mannitol dehydrogenase
I6N93_RS11730	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6N93_RS11730	COG2213	PTS system mannitol-specific
I6N93_RS11750	COG1566	PFAM secretion protein HlyD family protein
I6N93_RS11755	COG2814	Major facilitator Superfamily
I6N93_RS11765	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6N93_RS11765	COG0519	Catalyzes the synthesis of GMP from XMP
I6N93_RS11770	COG0516	GMP reductase activity
I6N93_RS11770	COG0517	IMP dehydrogenase activity
I6N93_RS11775	COG1570	exodeoxyribonuclease VII activity
I6N93_RS11790	COG1645	bacterial-type flagellum-dependent swarming motility
I6N93_RS11795	COG1160	GTP binding
I6N93_RS11800	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6N93_RS11805	COG2976	Protein conserved in bacteria
I6N93_RS11810	COG0124	histidyl-tRNA synthetase
I6N93_RS11815	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
I6N93_RS11820	COG1426	Protein conserved in bacteria
I6N93_RS11830	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I6N93_RS11835	COG0105	UTP biosynthetic process
I6N93_RS11840	COG2897	thiosulfate sulfurtransferase activity
I6N93_RS11850	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I6N93_RS11865	COG1959	2 iron, 2 sulfur cluster binding
I6N93_RS11870	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
I6N93_RS11875	COG0483	inositol monophosphate 1-phosphatase activity
I6N93_RS11885	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6N93_RS11890	COG1120	ATPase activity
I6N93_RS11895	COG2814	Major facilitator Superfamily
I6N93_RS11900	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I6N93_RS11905	COG3866	Pectate lyase
I6N93_RS11915	COG0347	Belongs to the P(II) protein family
I6N93_RS11920	COG2204	response regulator
I6N93_RS11925	COG3170	Tfp pilus assembly protein FimV
I6N93_RS11930	COG2205	protein histidine kinase activity
I6N93_RS11935	COG0047	phosphoribosylformylglycinamidine synthase activity
I6N93_RS11935	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6N93_RS11940	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
I6N93_RS11950	COG0560	Phosphoserine phosphatase
I6N93_RS11955	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
I6N93_RS11965	COG3300	MHYT domain
I6N93_RS11965	COG5001	Diguanylate cyclase
I6N93_RS12000	COG2200	EAL domain
I6N93_RS12005	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6N93_RS12010	COG0736	holo-[acyl-carrier-protein] synthase activity
I6N93_RS12015	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
I6N93_RS12020	COG1381	Involved in DNA repair and RecF pathway recombination
I6N93_RS12025	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I6N93_RS12030	COG0571	ribonuclease III activity
I6N93_RS12045	COG3026	antisigma factor binding
I6N93_RS12050	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
I6N93_RS12060	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
I6N93_RS12065	COG0513	Belongs to the DEAD box helicase family
I6N93_RS12070	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
I6N93_RS12075	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I6N93_RS12090	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6N93_RS12165	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
I6N93_RS12180	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
I6N93_RS12185	COG4208	sulfate ABC transporter
I6N93_RS12195	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
I6N93_RS12200	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6N93_RS12205	COG0232	Belongs to the dGTPase family. Type 2 subfamily
I6N93_RS12210	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6N93_RS12215	COG0316	Belongs to the HesB IscA family
I6N93_RS12220	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I6N93_RS12225	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6N93_RS12230	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6N93_RS12235	COG1120	ATPase activity
I6N93_RS12240	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6N93_RS12245	COG1643	Atp-dependent helicase
I6N93_RS12250	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
I6N93_RS12265	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6N93_RS12270	COG0617	tRNA 3'-terminal CCA addition
I6N93_RS12275	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I6N93_RS12280	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
I6N93_RS12285	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
I6N93_RS12290	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
I6N93_RS12295	COG0842	Transport permease protein
I6N93_RS12300	COG1131	(ABC) transporter
I6N93_RS12305	COG0288	reversible hydration of carbon dioxide
I6N93_RS12310	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
I6N93_RS12325	COG3344	reverse transcriptase
I6N93_RS12340	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6N93_RS12420	COG0582	viral genome integration into host DNA
I6N93_RS12440	COG1192	Involved in chromosome partitioning
I6N93_RS12460	COG4974	Belongs to the 'phage' integrase family
I6N93_RS12465	COG0358	DNA primase activity
I6N93_RS12470	COG1476	TRANSCRIPTIONal
I6N93_RS12490	COG2831	hemolysin activation secretion protein
I6N93_RS12495	COG0205	6-phosphofructokinase activity
I6N93_RS12515	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6N93_RS12530	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6N93_RS12540	COG2207	Transcriptional regulator
I6N93_RS12550	COG4975	Glucose uptake
I6N93_RS12590	COG0242	peptide deformylase activity
I6N93_RS12600	COG3895	Periplasmic Protein
I6N93_RS12605	COG0129	dihydroxy-acid dehydratase activity
I6N93_RS12610	COG3265	gluconokinase activity
I6N93_RS12650	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6N93_RS12650	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I6N93_RS12660	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6N93_RS12665	COG2960	long-chain fatty acid transporting porin activity
I6N93_RS12670	COG3115	cell septum assembly
I6N93_RS12675	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
I6N93_RS12685	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6N93_RS12690	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6N93_RS12695	COG2190	(PTS) system
I6N93_RS12700	COG2205	protein histidine kinase activity
I6N93_RS12705	COG0745	RESPONSE REGULATOR receiver
I6N93_RS12710	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6N93_RS12715	COG1136	(ABC) transporter
I6N93_RS12715	COG0577	efflux transmembrane transporter activity
I6N93_RS12725	COG2837	iron assimilation
I6N93_RS12735	COG0456	acetyltransferase
I6N93_RS12740	COG0408	coproporphyrinogen oxidase activity
I6N93_RS12745	COG1671	Belongs to the UPF0178 family
I6N93_RS12750	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6N93_RS12755	COG0494	nUDIX hydrolase
I6N93_RS12760	COG0583	DNA-binding transcription factor activity
I6N93_RS12765	COG0477	Major facilitator Superfamily
I6N93_RS12775	COG1942	4-Oxalocrotonate Tautomerase
I6N93_RS12780	COG1914	H( )-stimulated, divalent metal cation uptake system
I6N93_RS12785	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I6N93_RS12790	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I6N93_RS12795	COG0497	DNA recombination
I6N93_RS12805	COG2914	Belongs to the UPF0125 (RnfH) family
I6N93_RS12810	COG2867	negative regulation of translational initiation
I6N93_RS12815	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
I6N93_RS12845	COG3621	Patatin-like phospholipase
I6N93_RS12870	COG0582	viral genome integration into host DNA
I6N93_RS12880	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6N93_RS12885	COG0328	RNA-DNA hybrid ribonuclease activity
I6N93_RS12890	COG2226	methyltransferase
I6N93_RS12895	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6N93_RS12900	COG1388	LysM domain
I6N93_RS12900	COG0741	lytic transglycosylase activity
I6N93_RS12915	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6N93_RS12945	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
I6N93_RS12955	COG1877	trehalose-phosphatase activity
I6N93_RS12980	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6N93_RS12985	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6N93_RS12990	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
I6N93_RS13010	COG0789	Transcriptional regulator
I6N93_RS13030	COG0583	DNA-binding transcription factor activity
I6N93_RS13035	COG1942	4-Oxalocrotonate Tautomerase
I6N93_RS13050	COG1309	transcriptional regulator
I6N93_RS13070	COG0673	inositol 2-dehydrogenase activity
I6N93_RS13080	COG2211	Major facilitator Superfamily
I6N93_RS13085	COG2267	carboxylic ester hydrolase activity
I6N93_RS13090	COG0673	inositol 2-dehydrogenase activity
I6N93_RS13095	COG0481	GTPase activity
I6N93_RS13100	COG3713	MltA-interacting MipA family protein
I6N93_RS13110	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6N93_RS13115	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6N93_RS13120	COG1121	(ABC) transporter
I6N93_RS13165	COG0542	response to heat
I6N93_RS13175	COG0564	pseudouridine synthase activity
I6N93_RS13180	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6N93_RS13185	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I6N93_RS13190	COG1605	Chorismate mutase
I6N93_RS13190	COG0077	Prephenate dehydratase
I6N93_RS13195	COG1605	Chorismate mutase
I6N93_RS13195	COG0287	Prephenate dehydrogenase
I6N93_RS13200	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6N93_RS13210	COG0335	large ribosomal subunit rRNA binding
I6N93_RS13215	COG0336	Belongs to the RNA methyltransferase TrmD family
I6N93_RS13220	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I6N93_RS13225	COG0228	four-way junction DNA binding
I6N93_RS13230	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I6N93_RS13235	COG4137	Cytochrome C assembly protein
I6N93_RS13250	COG2814	Major facilitator Superfamily
I6N93_RS13260	COG0583	DNA-binding transcription factor activity
I6N93_RS13265	COG2814	Major facilitator Superfamily
I6N93_RS13280	COG1854	S-ribosylhomocysteine lyase activity
I6N93_RS13285	COG2918	glutathione biosynthetic process
I6N93_RS13290	COG1238	metal cluster binding
I6N93_RS13295	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6N93_RS13320	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
I6N93_RS13325	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6N93_RS13330	COG2137	regulation of response to DNA damage stimulus
I6N93_RS13335	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
I6N93_RS13340	COG1546	Belongs to the CinA family
I6N93_RS13375	COG5645	(Lipo)protein
I6N93_RS13385	COG0753	catalase activity
I6N93_RS13400	COG1169	isochorismate synthase
I6N93_RS13420	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6N93_RS13425	COG0640	Transcriptional regulator
I6N93_RS13430	COG2951	lytic endotransglycosylase activity
I6N93_RS13435	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6N93_RS13445	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
I6N93_RS13445	COG1013	pyruvate-flavodoxin oxidoreductase activity
I6N93_RS13445	COG0674	pyruvate-flavodoxin oxidoreductase activity
I6N93_RS13445	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6N93_RS13450	COG1376	ErfK ybiS ycfS ynhG family protein
I6N93_RS13470	COG0025	NhaP-type Na H and K H
I6N93_RS13475	COG2252	PERMEase
I6N93_RS13480	COG1560	Kdo2-lipid A biosynthetic process
I6N93_RS13485	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6N93_RS13500	COG0438	transferase activity, transferring glycosyl groups
I6N93_RS13510	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
I6N93_RS13535	COG0438	transferase activity, transferring glycosyl groups
I6N93_RS13550	COG0588	phosphoglycerate mutase activity
I6N93_RS13555	COG0438	transferase activity, transferring glycosyl groups
I6N93_RS13560	COG0438	transferase activity, transferring glycosyl groups
I6N93_RS13565	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I6N93_RS13635	COG0583	DNA-binding transcription factor activity
I6N93_RS13650	COG1011	Hydrolase
I6N93_RS13665	COG2814	Major facilitator Superfamily
I6N93_RS13715	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I6N93_RS13725	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I6N93_RS13730	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6N93_RS13735	COG4974	Belongs to the 'phage' integrase family
I6N93_RS13740	COG0477	Major facilitator Superfamily
I6N93_RS13745	COG0716	FMN binding
I6N93_RS13750	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
I6N93_RS13760	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
I6N93_RS13765	COG0354	folic acid binding
I6N93_RS13770	COG1272	protein, Hemolysin III
I6N93_RS13805	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I6N93_RS13805	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I6N93_RS13810	COG0509	glycine decarboxylation via glycine cleavage system
I6N93_RS13815	COG0404	The glycine cleavage system catalyzes the degradation of glycine
I6N93_RS13835	COG4774	siderophore transport
I6N93_RS13860	COG0583	DNA-binding transcription factor activity
I6N93_RS13865	COG0667	Aldo Keto reductase
I6N93_RS13870	COG2813	Specifically methylates the guanine in position
I6N93_RS13875	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
I6N93_RS13885	COG1595	DNA-templated transcription, initiation
I6N93_RS13890	COG3712	iron ion homeostasis
I6N93_RS13900	COG4178	(ABC) transporter
I6N93_RS13910	COG0813	purine-nucleoside phosphorylase activity
I6N93_RS13915	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
I6N93_RS13920	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
I6N93_RS13925	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
I6N93_RS13940	COG3153	acetyltransferase
I6N93_RS13945	COG3154	lipid carrier protein
I6N93_RS13950	COG0826	peptidase U32
I6N93_RS13955	COG0826	peptidase U32
I6N93_RS13960	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6N93_RS13965	COG0513	Belongs to the DEAD box helicase family
I6N93_RS13980	COG1185	polyribonucleotide nucleotidyltransferase activity
I6N93_RS13990	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I6N93_RS13995	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I6N93_RS14000	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
I6N93_RS14005	COG0195	Participates in both transcription termination and antitermination
I6N93_RS14025	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6N93_RS14030	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6N93_RS14035	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I6N93_RS14040	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6N93_RS14050	COG1534	Rna-binding protein
I6N93_RS14060	COG2027	D-alanyl-D-alanine carboxypeptidase
I6N93_RS14065	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
I6N93_RS14070	COG0697	spore germination
I6N93_RS14080	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I6N93_RS14085	COG0142	geranyltranstransferase activity
I6N93_RS14100	COG3423	Transcriptional regulator
I6N93_RS14110	COG1438	arginine binding
I6N93_RS14115	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I6N93_RS14120	COG0828	Belongs to the bacterial ribosomal protein bS21 family
I6N93_RS14125	COG0358	DNA primase activity
I6N93_RS14140	COG3663	DNA glycosylase
I6N93_RS14200	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
I6N93_RS14285	COG4695	Portal protein
I6N93_RS14325	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I6N93_RS14360	COG4974	Belongs to the 'phage' integrase family
I6N93_RS14395	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
I6N93_RS14455	COG3678	ATP-independent chaperone mediated protein folding
I6N93_RS14465	COG2813	Specifically methylates the guanine in position
I6N93_RS14470	COG0861	Integral membrane protein TerC family
I6N93_RS14475	COG0586	Pfam SNARE associated Golgi protein
I6N93_RS14485	COG4575	ribosome binding
I6N93_RS14490	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
I6N93_RS14500	COG2259	Doxx family
I6N93_RS14505	COG0435	Glutathione S-transferase
I6N93_RS14510	COG0583	DNA-binding transcription factor activity
I6N93_RS14515	COG1741	Belongs to the pirin family
I6N93_RS14520	COG0735	belongs to the Fur family
I6N93_RS14525	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6N93_RS14530	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I6N93_RS14535	COG2937	Belongs to the GPAT DAPAT family
I6N93_RS14540	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
I6N93_RS14555	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I6N93_RS14570	COG1324	tolerance protein
I6N93_RS14575	COG4232	protein-disulfide reductase activity
I6N93_RS14580	COG1309	transcriptional regulator
I6N93_RS14610	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
I6N93_RS14615	COG4172	Belongs to the ABC transporter superfamily
I6N93_RS14620	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6N93_RS14625	COG0601	transmembrane transport
I6N93_RS14630	COG0747	negative chemotaxis
I6N93_RS14645	COG0679	Auxin Efflux Carrier
I6N93_RS14665	COG0659	secondary active sulfate transmembrane transporter activity
I6N93_RS14680	COG2267	carboxylic ester hydrolase activity
I6N93_RS14745	COG1802	Transcriptional regulator
I6N93_RS14770	COG0410	ABC transporter
I6N93_RS14785	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6N93_RS14790	COG0084	hydrolase, TatD family'
I6N93_RS14800	COG2823	Periplasmic or secreted lipoprotein
I6N93_RS14805	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
I6N93_RS14810	COG3726	membrane protein affecting hemolysin expression
I6N93_RS14815	COG0560	Phosphoserine phosphatase
I6N93_RS14830	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6N93_RS14840	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
I6N93_RS14850	COG0006	proline dipeptidase activity
I6N93_RS14855	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6N93_RS14860	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6N93_RS14870	COG0288	reversible hydration of carbon dioxide
I6N93_RS14875	COG0659	secondary active sulfate transmembrane transporter activity
I6N93_RS14885	COG1605	Chorismate mutase
I6N93_RS14890	COG2271	Major facilitator Superfamily
I6N93_RS14895	COG3851	Histidine kinase
I6N93_RS14900	COG2197	response regulator
I6N93_RS14940	COG3829	transcription factor binding
I6N93_RS15005	COG3501	Rhs element vgr protein
I6N93_RS15015	COG4104	PAAR repeat-containing protein
I6N93_RS15015	COG3209	COG3209 Rhs family protein
I6N93_RS15030	COG3620	sequence-specific DNA binding
I6N93_RS15040	COG4104	PAAR repeat-containing protein
I6N93_RS15040	COG3209	COG3209 Rhs family protein
I6N93_RS15060	COG0358	DNA primase activity
I6N93_RS15065	COG4974	Belongs to the 'phage' integrase family
I6N93_RS15095	COG0358	DNA primase activity
I6N93_RS15100	COG4974	Belongs to the 'phage' integrase family
I6N93_RS15145	COG3423	Transcriptional regulator
I6N93_RS15180	COG0582	viral genome integration into host DNA
I6N93_RS15190	COG2733	membrane
I6N93_RS15195	COG0795	lipopolysaccharide-transporting ATPase activity
I6N93_RS15200	COG0795	lipopolysaccharide-transporting ATPase activity
I6N93_RS15205	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I6N93_RS15210	COG2927	DNA polymerase III (CHI subunit)
I6N93_RS15220	COG0456	acetyltransferase
I6N93_RS15230	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I6N93_RS15235	COG0540	Belongs to the ATCase OTCase family
I6N93_RS15240	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
I6N93_RS15250	COG4172	Belongs to the ABC transporter superfamily
I6N93_RS15260	COG0601	transmembrane transport
I6N93_RS15275	COG1328	CTP reductase activity
I6N93_RS15280	COG0602	queuosine metabolic process
I6N93_RS15310	COG0848	biopolymer transport protein
I6N93_RS15330	COG2207	Transcriptional regulator
I6N93_RS15335	COG0778	Nitroreductase
I6N93_RS15340	COG1979	alcohol dehydrogenase
I6N93_RS15345	COG0656	L-ascorbic acid biosynthetic process
I6N93_RS15350	COG2186	Transcriptional regulator
I6N93_RS15355	COG1397	ADP-ribosylglycohydrolase
I6N93_RS15365	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6N93_RS15370	COG2132	Multicopper oxidase
I6N93_RS15385	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6N93_RS15390	COG0583	DNA-binding transcription factor activity
I6N93_RS15400	COG3150	esterase
I6N93_RS15405	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6N93_RS15410	COG3151	Protein conserved in bacteria
I6N93_RS15415	COG0494	nUDIX hydrolase
I6N93_RS15420	COG1538	Outer membrane efflux protein
I6N93_RS15425	COG5463	Belongs to the UPF0441 family
I6N93_RS15430	COG0754	glutathionylspermidine amidase activity
I6N93_RS15440	COG3384	dioxygenase
I6N93_RS15445	COG0583	DNA-binding transcription factor activity
I6N93_RS15450	COG3479	Phenolic acid decarboxylase
I6N93_RS15460	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I6N93_RS15465	COG3107	peptidoglycan biosynthetic process
I6N93_RS15470	COG0792	nuclease activity
I6N93_RS15475	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
I6N93_RS15480	COG2823	Periplasmic or secreted lipoprotein
I6N93_RS15485	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6N93_RS15490	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
I6N93_RS15495	COG5002	protein histidine kinase activity
I6N93_RS15495	COG2198	Histidine kinase
I6N93_RS15495	COG0784	Response regulator, receiver
I6N93_RS15500	COG1242	4 iron, 4 sulfur cluster binding
I6N93_RS15505	COG0067	glutamate synthase
I6N93_RS15505	COG0069	glutamate synthase activity
I6N93_RS15505	COG0070	glutamate synthase
I6N93_RS15510	COG0493	'glutamate synthase
I6N93_RS15520	COG2969	positive regulation of protein catabolic process
I6N93_RS15525	COG0625	glutathione transferase activity
I6N93_RS15530	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I6N93_RS15540	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I6N93_RS15545	COG3105	Protein conserved in bacteria
I6N93_RS15550	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6N93_RS15555	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6N93_RS15560	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I6N93_RS15565	COG5007	Belongs to the BolA IbaG family
I6N93_RS15570	COG3113	response to antibiotic
I6N93_RS15575	COG2854	intermembrane phospholipid transfer
I6N93_RS15580	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6N93_RS15585	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I6N93_RS15590	COG1127	ABC transporter
I6N93_RS15595	COG0530	calcium, potassium:sodium antiporter activity
I6N93_RS15600	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I6N93_RS15600	COG0517	IMP dehydrogenase activity
I6N93_RS15605	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
I6N93_RS15610	COG3117	lipopolysaccharide transmembrane transporter activity
I6N93_RS15615	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
I6N93_RS15620	COG1137	ATPase activity
I6N93_RS15625	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
I6N93_RS15635	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6N93_RS15640	COG1660	Displays ATPase and GTPase activities
I6N93_RS15645	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6N93_RS15655	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
I6N93_RS15655	COG0028	Belongs to the TPP enzyme family
I6N93_RS15665	COG3624	Phosphonate C-P lyase system protein PhnG
I6N93_RS15670	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
I6N93_RS15675	COG3626	phosphonate metabolism
I6N93_RS15680	COG3627	carbon phosphorus lyase activity
I6N93_RS15685	COG4107	phosphonate C-P lyase system protein PhnK
I6N93_RS15690	COG4778	phosphonate C-P lyase system protein PhnL
I6N93_RS15695	COG3454	Phosphonate metabolism
I6N93_RS15700	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
I6N93_RS15705	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I6N93_RS15710	COG0312	modulator of DNA gyrase
I6N93_RS15715	COG3028	Belongs to the UPF0307 family
I6N93_RS15720	COG1280	lysine exporter protein (LysE YggA)
I6N93_RS15725	COG1289	transmembrane transporter activity
I6N93_RS15730	COG1566	PFAM secretion protein HlyD family protein
I6N93_RS15740	COG0583	DNA-binding transcription factor activity
I6N93_RS15745	COG0312	modulator of DNA gyrase
I6N93_RS15750	COG3164	Protein of unknown function
I6N93_RS15755	COG1530	ribonuclease E activity
I6N93_RS15760	COG0424	maF-like protein
I6N93_RS15765	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
I6N93_RS15770	COG1792	Involved in formation and maintenance of cell shape
I6N93_RS15775	COG1077	Cell shape determining protein MreB Mrl
I6N93_RS15780	COG2200	EAL domain
I6N93_RS15780	COG2199	diguanylate cyclase activity
I6N93_RS15785	COG0604	alcohol dehydrogenase
I6N93_RS15790	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
I6N93_RS15795	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
I6N93_RS15800	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
I6N93_RS15805	COG0511	ligase activity, forming carbon-carbon bonds
I6N93_RS15810	COG0439	Biotin carboxylase
I6N93_RS15815	COG3924	membrane
I6N93_RS15820	COG4145	pantothenate transmembrane transporter activity
I6N93_RS15825	COG2264	protein methyltransferase activity
I6N93_RS15835	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
I6N93_RS15850	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I6N93_RS15855	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6N93_RS15860	COG0765	amino acid transport
I6N93_RS15865	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6N93_RS15870	COG4597	amino acid ABC transporter
I6N93_RS15875	COG0765	amino acid transport
I6N93_RS15880	COG1126	abc transporter atp-binding protein
I6N93_RS15905	COG0138	bifunctional purine biosynthesis protein purh
I6N93_RS15910	COG0151	Belongs to the GarS family
I6N93_RS15930	COG1515	deoxyribonuclease V activity
I6N93_RS15935	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
I6N93_RS15940	COG2816	NAD+ diphosphatase activity
I6N93_RS15945	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
I6N93_RS15950	COG0352	thiamine-phosphate diphosphorylase activity
I6N93_RS15955	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6N93_RS15960	COG2104	thiamine diphosphate biosynthetic process
I6N93_RS15965	COG2022	thiamine diphosphate biosynthetic process
I6N93_RS15975	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6N93_RS15980	COG5457	Domain of unknown function (DUF1127)
I6N93_RS15990	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I6N93_RS15995	COG0085	RNA polymerase activity
I6N93_RS16000	COG0222	ribosome binding
I6N93_RS16005	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I6N93_RS16010	COG0081	regulation of translation
I6N93_RS16020	COG0250	Participates in transcription elongation, termination and antitermination
I6N93_RS16030	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6N93_RS16060	COG1072	(Pantothenic acid kinase))
I6N93_RS16065	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
I6N93_RS16065	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
I6N93_RS16070	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I6N93_RS16100	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I6N93_RS16105	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6N93_RS16130	COG0460	homoserine dehydrogenase
I6N93_RS16130	COG0527	aspartate kinase activity
I6N93_RS16135	COG0626	cystathionine gamma-synthase activity
I6N93_RS16140	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
I6N93_RS16145	COG0254	rRNA binding
I6N93_RS16150	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6N93_RS16155	COG1609	Transcriptional regulator
I6N93_RS16160	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I6N93_RS16165	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
I6N93_RS16170	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
I6N93_RS16175	COG1575	Belongs to the MenA family. Type 1 subfamily
I6N93_RS16180	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I6N93_RS16185	COG3074	FtsZ-dependent cytokinesis
I6N93_RS16190	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6N93_RS16200	COG1494	fructose-1,6-bisphosphatase
I6N93_RS16210	COG3152	Membrane
I6N93_RS16220	COG0149	triose-phosphate isomerase activity
I6N93_RS16230	COG2957	Belongs to the agmatine deiminase family
I6N93_RS16235	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6N93_RS16240	COG0205	6-phosphofructokinase activity
I6N93_RS16245	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I6N93_RS16280	COG3678	ATP-independent chaperone mediated protein folding
I6N93_RS16285	COG0745	RESPONSE REGULATOR receiver
I6N93_RS16290	COG2205	protein histidine kinase activity
I6N93_RS16300	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I6N93_RS16310	COG0679	Auxin Efflux Carrier
I6N93_RS16315	COG0584	glycerophosphoryl diester phosphodiesterase
I6N93_RS16320	COG3842	ATPase activity
I6N93_RS16325	COG0395	ABC-type sugar transport system, permease component
I6N93_RS16330	COG1175	transmembrane transport
I6N93_RS16335	COG1653	transport
I6N93_RS16340	COG0840	transmembrane signaling receptor activity
I6N93_RS16345	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6N93_RS16355	COG0411	ABC transporter
I6N93_RS16360	COG4177	L-phenylalanine transmembrane transporter activity
I6N93_RS16365	COG0559	Belongs to the binding-protein-dependent transport system permease family
I6N93_RS16375	COG0456	acetyltransferase
I6N93_RS16385	COG2177	Part of the ABC transporter FtsEX involved in
I6N93_RS16390	COG2884	Cell division ATP-binding protein ftsE
I6N93_RS16395	COG0552	protein localization to endoplasmic reticulum
I6N93_RS16400	COG0742	ribosomal rna small subunit methyltransferase
I6N93_RS16405	COG3776	membrane
I6N93_RS16415	COG3714	YhhN family
I6N93_RS16425	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
I6N93_RS16435	COG1295	ribonuclease BN
I6N93_RS16440	COG1942	4-Oxalocrotonate Tautomerase
I6N93_RS16450	COG1301	dicarboxylic acid transport
I6N93_RS16455	COG2200	EAL domain
I6N93_RS16455	COG2199	diguanylate cyclase activity
I6N93_RS16460	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
I6N93_RS16470	COG0457	Tetratricopeptide repeat
I6N93_RS16485	COG2894	cell division
I6N93_RS16495	COG4608	Belongs to the ABC transporter superfamily
I6N93_RS16500	COG0444	Belongs to the ABC transporter superfamily
I6N93_RS16505	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6N93_RS16510	COG0601	transmembrane transport
I6N93_RS16515	COG0747	negative chemotaxis
I6N93_RS16520	COG3493	citrate carrier protein
I6N93_RS16525	COG4565	transcriptional regulatory protein
I6N93_RS16530	COG3290	protein histidine kinase activity
I6N93_RS16535	COG0471	metal ion transport
I6N93_RS16540	COG0071	Belongs to the small heat shock protein (HSP20) family
I6N93_RS16545	COG0071	Belongs to the small heat shock protein (HSP20) family
I6N93_RS16550	COG5645	(Lipo)protein
I6N93_RS16555	COG0823	Involved in the tonB-independent uptake of proteins
I6N93_RS16565	COG0561	phosphatase activity
I6N93_RS16570	COG0589	response to stress
I6N93_RS16580	COG0306	phosphate transporter
I6N93_RS16585	COG2081	HI0933 family
I6N93_RS16600	COG2194	sulfuric ester hydrolase activity
I6N93_RS16605	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I6N93_RS16610	COG0194	GDP metabolic process
I6N93_RS16615	COG1758	RNA polymerase activity
I6N93_RS16620	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6N93_RS16625	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6N93_RS16630	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I6N93_RS16635	COG2233	PERMEase
I6N93_RS16640	COG2982	Protein involved in outer membrane biogenesis
I6N93_RS16645	COG0456	acetyltransferase
I6N93_RS16650	COG1490	D-aminoacyl-tRNA deacylase activity
I6N93_RS16655	COG1011	Hydrolase
I6N93_RS16665	COG0174	glutamine synthetase
I6N93_RS16670	COG3852	Histidine kinase
I6N93_RS16685	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6N93_RS16690	COG3078	GTPase activator activity
I6N93_RS16700	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6N93_RS16700	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6N93_RS16715	COG3084	Protein conserved in bacteria
I6N93_RS16720	COG0746	molybdenum cofactor guanylyltransferase activity
I6N93_RS16725	COG1763	Mo-molybdopterin cofactor biosynthetic process
I6N93_RS16750	COG1609	Transcriptional regulator
I6N93_RS16755	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6N93_RS16760	COG1879	ABC-type sugar transport system periplasmic component
I6N93_RS16765	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6N93_RS16770	COG1129	ABC transporter
I6N93_RS16775	COG1869	D-ribose catabolic process
I6N93_RS16780	COG3111	PFAM Bacterial OB fold (BOF) protein
I6N93_RS16785	COG0745	RESPONSE REGULATOR receiver
I6N93_RS16790	COG0642	Histidine kinase
I6N93_RS16795	COG3158	transport of potassium into the cell
I6N93_RS16800	COG0714	Associated with various cellular activities
I6N93_RS16805	COG2425	protein containing a von Willebrand factor type A (vWA) domain
I6N93_RS16810	COG1522	sequence-specific DNA binding
I6N93_RS16815	COG0716	FMN binding
I6N93_RS16820	COG0445	tRNA wobble uridine modification
I6N93_RS16825	COG0357	Ribosomal RNA small subunit methyltransferase G
I6N93_RS16830	COG3312	ion transport
I6N93_RS16835	COG0356	it plays a direct role in the translocation of protons across the membrane
I6N93_RS16845	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
I6N93_RS16850	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I6N93_RS16855	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
I6N93_RS16860	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
I6N93_RS16865	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I6N93_RS16870	COG0355	proton-transporting ATP synthase activity, rotational mechanism
I6N93_RS16875	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I6N93_RS16880	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6N93_RS16910	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6N93_RS16925	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6N93_RS16930	COG1216	Glycosyl transferase, family 2
I6N93_RS16955	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6N93_RS16965	COG1028	Short-chain dehydrogenase reductase Sdr
I6N93_RS16975	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I6N93_RS16980	COG0573	inorganic phosphate transmembrane transporter activity
I6N93_RS16985	COG0581	inorganic phosphate transmembrane transporter activity
I6N93_RS16990	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6N93_RS17000	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6N93_RS17010	COG0765	amino acid transport
I6N93_RS17015	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6N93_RS17020	COG2252	PERMEase
I6N93_RS17025	COG2091	lysine biosynthetic process via aminoadipic acid
I6N93_RS17030	COG0493	'glutamate synthase
I6N93_RS17030	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6N93_RS17035	COG0493	'glutamate synthase
I6N93_RS17035	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6N93_RS17040	COG1289	transmembrane transporter activity
I6N93_RS17045	COG0697	spore germination
I6N93_RS17060	COG1984	allophanate hydrolase subunit 2
I6N93_RS17065	COG0436	Aminotransferase
I6N93_RS17080	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
I6N93_RS17085	COG4221	oxidoreductase activity
I6N93_RS17090	COG0765	amino acid transport
I6N93_RS17095	COG0765	amino acid transport
I6N93_RS17105	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
I6N93_RS17150	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
I6N93_RS17155	COG0706	membrane insertase activity
I6N93_RS17170	COG0230	Belongs to the bacterial ribosomal protein bL34 family