locus-tag	class	description
IDM46_RS00010	COG0592	DNA-directed DNA polymerase activity
IDM46_RS00020	COG0187	DNA topoisomerase II activity
IDM46_RS00025	COG0501	Belongs to the peptidase M48B family
IDM46_RS00065	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IDM46_RS00075	COG0784	Response regulator, receiver
IDM46_RS00090	COG4772	TonB-dependent receptor
IDM46_RS00095	COG3186	Phenylalanine-4-hydroxylase
IDM46_RS00335	COG3657	addiction module killer protein
IDM46_RS00340	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IDM46_RS00385	COG0705	Rhomboid family
IDM46_RS00445	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IDM46_RS00455	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IDM46_RS00465	COG1322	Protein conserved in bacteria
IDM46_RS00470	COG2853	Lipoprotein
IDM46_RS00485	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IDM46_RS00490	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IDM46_RS00495	COG1127	ABC transporter
IDM46_RS00500	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
IDM46_RS00505	COG1074	ATP-dependent DNA helicase activity
IDM46_RS00525	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IDM46_RS00575	COG1819	glycosyl
IDM46_RS00580	COG0339	signal peptide processing
IDM46_RS00610	COG0302	gtp cyclohydrolase
IDM46_RS00635	COG2951	lytic endotransglycosylase activity
IDM46_RS00655	COG0443	Heat shock 70 kDa protein
IDM46_RS00675	COG3300	MHYT domain
IDM46_RS00675	COG5001	Diguanylate cyclase
IDM46_RS00685	COG0405	Gamma-glutamyltransferase
IDM46_RS00705	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IDM46_RS00725	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IDM46_RS00740	COG2050	protein possibly involved in aromatic compounds catabolism
IDM46_RS00760	COG1881	PFAM PEBP family protein
IDM46_RS00770	COG1968	undecaprenyl-diphosphatase activity
IDM46_RS00775	COG0174	glutamine synthetase
IDM46_RS00780	COG3023	N-Acetylmuramoyl-L-alanine amidase
IDM46_RS00785	COG2353	YceI-like domain
IDM46_RS00790	COG1741	Belongs to the pirin family
IDM46_RS00795	COG2353	YceI-like domain
IDM46_RS00800	COG3852	Histidine kinase
IDM46_RS00805	COG2204	response regulator
IDM46_RS00815	COG2032	superoxide dismutase activity
IDM46_RS00845	COG0456	acetyltransferase
IDM46_RS00855	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IDM46_RS00860	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
IDM46_RS00875	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
IDM46_RS00885	COG0612	Peptidase, M16
IDM46_RS00895	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IDM46_RS00920	COG2091	lysine biosynthetic process via aminoadipic acid
IDM46_RS00945	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IDM46_RS00955	COG0596	Alpha beta hydrolase
IDM46_RS00960	COG0727	PFAM Uncharacterised protein family (UPF0153)
IDM46_RS00965	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
IDM46_RS00970	COG0318	PFAM AMP-dependent synthetase and ligase
IDM46_RS00975	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IDM46_RS00990	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IDM46_RS00995	COG0564	pseudouridine synthase activity
IDM46_RS01020	COG1595	DNA-templated transcription, initiation
IDM46_RS01030	COG0583	DNA-binding transcription factor activity
IDM46_RS01035	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
IDM46_RS01040	COG2224	Isocitrate lyase
IDM46_RS01045	COG0606	chelatase, subunit chli
IDM46_RS01050	COG2960	long-chain fatty acid transporting porin activity
IDM46_RS01065	COG1166	arginine decarboxylase activity
IDM46_RS01075	COG4221	oxidoreductase activity
IDM46_RS01090	COG0018	arginyl-trna synthetase
IDM46_RS01125	COG0708	Exodeoxyribonuclease III
IDM46_RS01130	COG2211	Major facilitator Superfamily
IDM46_RS01145	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
IDM46_RS01150	COG0739	heme binding
IDM46_RS01155	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
IDM46_RS01170	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
IDM46_RS01175	COG4942	peptidase
IDM46_RS01180	COG0793	Belongs to the peptidase S41A family
IDM46_RS01200	COG1565	acr, cog1565
IDM46_RS01200	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IDM46_RS01215	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
IDM46_RS01240	COG1612	heme a metabolic process
IDM46_RS01245	COG0109	protoheme IX farnesyltransferase activity
IDM46_RS01265	COG0358	DNA primase activity
IDM46_RS01285	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
IDM46_RS01290	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
IDM46_RS01295	COG0668	transmembrane transport
IDM46_RS01300	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
IDM46_RS01335	COG0730	response to heat
IDM46_RS01355	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
IDM46_RS01380	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
IDM46_RS01400	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IDM46_RS01405	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IDM46_RS01410	COG3657	addiction module killer protein
IDM46_RS01420	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IDM46_RS01435	COG0218	Necessary for normal cell division and for the maintenance of normal septation
IDM46_RS01445	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
IDM46_RS01465	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
IDM46_RS01495	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
IDM46_RS01495	COG2755	lipolytic protein G-D-S-L family
IDM46_RS01500	COG1228	amidohydrolase
IDM46_RS01505	COG1228	amidohydrolase
IDM46_RS01520	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
IDM46_RS01540	COG5507	3-demethylubiquinone-9 3-methyltransferase
IDM46_RS01560	COG0436	Aminotransferase
IDM46_RS01575	COG0281	malic enzyme
IDM46_RS01575	COG0280	phosphate acetyltransferase
IDM46_RS01585	COG0784	Response regulator, receiver
IDM46_RS01590	COG2205	protein histidine kinase activity
IDM46_RS01615	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IDM46_RS01635	COG1376	ErfK ybiS ycfS ynhG family protein
IDM46_RS01640	COG0739	heme binding
IDM46_RS01650	COG4181	ATPase activity
IDM46_RS01655	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
IDM46_RS01680	COG2813	Specifically methylates the guanine in position
IDM46_RS01685	COG1187	pseudouridine synthase activity
IDM46_RS01695	COG1666	GTP binding
IDM46_RS01700	COG1064	alcohol dehydrogenase
IDM46_RS01705	COG0697	spore germination
IDM46_RS01720	COG0508	dehydrogenase complex catalyzes the overall conversion of
IDM46_RS01725	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IDM46_RS01740	COG0356	it plays a direct role in the translocation of protons across the membrane
IDM46_RS01750	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
IDM46_RS01755	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IDM46_RS01760	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
IDM46_RS01765	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
IDM46_RS01770	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
IDM46_RS01775	COG0355	proton-transporting ATP synthase activity, rotational mechanism
IDM46_RS01790	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
IDM46_RS01795	COG4191	Histidine kinase
IDM46_RS01795	COG2205	protein histidine kinase activity
IDM46_RS01795	COG0745	RESPONSE REGULATOR receiver
IDM46_RS01810	COG0577	efflux transmembrane transporter activity
IDM46_RS01810	COG1136	(ABC) transporter
IDM46_RS01815	COG0577	efflux transmembrane transporter activity
IDM46_RS01815	COG1136	(ABC) transporter
IDM46_RS01830	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IDM46_RS01840	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IDM46_RS01845	COG1335	isochorismatase
IDM46_RS01855	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IDM46_RS01865	COG0463	Glycosyl transferase, family 2
IDM46_RS01870	COG2194	sulfuric ester hydrolase activity
IDM46_RS01885	COG0745	RESPONSE REGULATOR receiver
IDM46_RS01890	COG2205	protein histidine kinase activity
IDM46_RS01900	COG4206	TonB-dependent receptor
IDM46_RS01910	COG1956	GAF domain-containing protein
IDM46_RS01915	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
IDM46_RS01920	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IDM46_RS01925	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IDM46_RS01940	COG4948	Mandelate Racemase Muconate Lactonizing
IDM46_RS01945	COG0786	glutamate:sodium symporter activity
IDM46_RS01960	COG0720	synthase
IDM46_RS01990	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IDM46_RS01995	COG0577	efflux transmembrane transporter activity
IDM46_RS02000	COG1136	(ABC) transporter
IDM46_RS02080	COG1704	LemA family
IDM46_RS02100	COG0151	Belongs to the GarS family
IDM46_RS02105	COG0138	bifunctional purine biosynthesis protein purh
IDM46_RS02110	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
IDM46_RS02120	COG2264	protein methyltransferase activity
IDM46_RS02130	COG0439	Biotin carboxylase
IDM46_RS02135	COG0511	ligase activity, forming carbon-carbon bonds
IDM46_RS02140	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
IDM46_RS02145	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IDM46_RS02155	COG2356	endonuclease I
IDM46_RS02170	COG0459	protein refolding
IDM46_RS02175	COG2354	Protein conserved in bacteria
IDM46_RS02180	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IDM46_RS02190	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
IDM46_RS02195	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
IDM46_RS02200	COG0484	heat shock protein binding
IDM46_RS02205	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
IDM46_RS02210	COG1597	lipid kinase activity
IDM46_RS02225	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IDM46_RS02235	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
IDM46_RS02235	COG0189	ligase activity
IDM46_RS02240	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
IDM46_RS02240	COG0189	ligase activity
IDM46_RS02245	COG0134	indole-3-glycerol-phosphate synthase activity
IDM46_RS02265	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IDM46_RS02270	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
IDM46_RS02280	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
IDM46_RS02290	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IDM46_RS02310	COG0625	glutathione transferase activity
IDM46_RS02340	COG0626	cystathionine gamma-synthase activity
IDM46_RS02350	COG1216	Glycosyl transferase, family 2
IDM46_RS02350	COG0438	transferase activity, transferring glycosyl groups
IDM46_RS02355	COG0438	transferase activity, transferring glycosyl groups
IDM46_RS02355	COG1216	Glycosyl transferase, family 2
IDM46_RS02400	COG2086	electron transfer activity
IDM46_RS02435	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
IDM46_RS02450	COG0463	Glycosyl transferase, family 2
IDM46_RS02460	COG0644	oxidoreductase
IDM46_RS02460	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
IDM46_RS02475	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IDM46_RS02475	COG3218	ABC-type transport auxiliary lipoprotein component
IDM46_RS02480	COG1127	ABC transporter
IDM46_RS02485	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IDM46_RS02500	COG0442	prolyl-tRNA aminoacylation
IDM46_RS02515	COG1183	phosphatidylcholine synthase activity
IDM46_RS02540	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IDM46_RS02560	COG0126	phosphoglycerate kinase activity
IDM46_RS02570	COG0469	pyruvate kinase activity
IDM46_RS02575	COG3588	fructose-bisphosphate aldolase
IDM46_RS02590	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IDM46_RS02595	COG1115	amino acid carrier protein
IDM46_RS02600	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IDM46_RS02610	COG1970	mechanosensitive ion channel activity
IDM46_RS02630	COG3273	potassium ion transport
IDM46_RS02630	COG0471	metal ion transport
IDM46_RS02640	COG2022	thiamine diphosphate biosynthetic process
IDM46_RS02660	COG0189	ligase activity
IDM46_RS02670	COG0745	RESPONSE REGULATOR receiver
IDM46_RS02690	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
IDM46_RS02705	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
IDM46_RS02715	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IDM46_RS02720	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IDM46_RS02725	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
IDM46_RS02735	COG0667	Aldo Keto reductase
IDM46_RS02740	COG0330	HflC and HflK could
IDM46_RS02755	COG0509	glycine decarboxylation via glycine cleavage system
IDM46_RS02770	COG1704	LemA family
IDM46_RS02775	COG0501	Belongs to the peptidase M48B family
IDM46_RS02805	COG0457	Tetratricopeptide repeat
IDM46_RS02820	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
IDM46_RS02830	COG0463	Glycosyl transferase, family 2
IDM46_RS02835	COG0517	IMP dehydrogenase activity
IDM46_RS02835	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
IDM46_RS02840	COG2982	Protein involved in outer membrane biogenesis
IDM46_RS02845	COG1272	protein, Hemolysin III
IDM46_RS02860	COG0739	heme binding
IDM46_RS02870	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IDM46_RS02875	COG0626	cystathionine gamma-synthase activity
IDM46_RS02880	COG0527	aspartate kinase activity
IDM46_RS02880	COG0460	homoserine dehydrogenase
IDM46_RS02885	COG1760	l-serine dehydratase
IDM46_RS02895	COG3038	cytochrome b561
IDM46_RS02910	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
IDM46_RS02920	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
IDM46_RS02945	COG2259	Doxx family
IDM46_RS02975	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IDM46_RS02980	COG1047	Peptidyl-prolyl cis-trans
IDM46_RS02985	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
IDM46_RS02995	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
IDM46_RS03000	COG0540	Belongs to the ATCase OTCase family
IDM46_RS03005	COG2239	Acts as a magnesium transporter
IDM46_RS03015	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IDM46_RS03020	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IDM46_RS03040	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
IDM46_RS03055	COG1137	ATPase activity
IDM46_RS03070	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
IDM46_RS03075	COG0517	IMP dehydrogenase activity
IDM46_RS03075	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
IDM46_RS03080	COG0271	Belongs to the BolA IbaG family
IDM46_RS03085	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IDM46_RS03100	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
IDM46_RS03105	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
IDM46_RS03115	COG0628	permease
IDM46_RS03120	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
IDM46_RS03125	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IDM46_RS03140	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
IDM46_RS03155	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
IDM46_RS03165	COG1595	DNA-templated transcription, initiation
IDM46_RS03175	COG1946	Acyl-CoA thioesterase
IDM46_RS03190	COG0116	Belongs to the methyltransferase superfamily
IDM46_RS03190	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IDM46_RS03195	COG1741	Belongs to the pirin family
IDM46_RS03205	COG1741	Belongs to the pirin family
IDM46_RS03210	COG1515	deoxyribonuclease V activity
IDM46_RS03220	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
IDM46_RS03225	COG3178	'Phosphotransferase
IDM46_RS03235	COG0175	sulfate reduction
IDM46_RS03240	COG2895	sulfate adenylyltransferase (ATP) activity
IDM46_RS03240	COG0529	Catalyzes the synthesis of activated sulfate
IDM46_RS03245	COG2261	transglycosylase associated protein
IDM46_RS03265	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
IDM46_RS03270	COG1477	protein flavinylation
IDM46_RS03290	COG4771	TonB-dependent receptor
IDM46_RS03295	COG4774	siderophore transport
IDM46_RS03300	COG2146	nitrite reductase [NAD(P)H] activity
IDM46_RS03310	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IDM46_RS03315	COG0719	Fe-S assembly protein
IDM46_RS03320	COG0396	ATPase activity
IDM46_RS03325	COG0719	Fe-S assembly protein
IDM46_RS03350	COG4942	peptidase
IDM46_RS03355	COG2979	Protein of unknown function (DUF533)
IDM46_RS03365	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IDM46_RS03370	COG1764	response to oxidative stress
IDM46_RS03380	COG1574	metal-dependent hydrolase with the TIM-barrel fold
IDM46_RS03385	COG0384	phenazine biosynthesis protein PhzF
IDM46_RS03390	COG0527	aspartate kinase activity
IDM46_RS03400	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
IDM46_RS03405	COG0142	geranyltranstransferase activity
IDM46_RS03410	COG0629	single-stranded DNA binding
IDM46_RS03440	COG1297	OPT oligopeptide transporter protein
IDM46_RS03445	COG0823	Involved in the tonB-independent uptake of proteins
IDM46_RS03445	COG1506	peptidase
IDM46_RS03455	COG0463	Glycosyl transferase, family 2
IDM46_RS03470	COG2879	small protein
IDM46_RS03475	COG1966	Carbon starvation protein
IDM46_RS03490	COG4535	Mg2 and Co2 transporter CorC
IDM46_RS03500	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
IDM46_RS03505	COG1702	phosphate starvation-inducible protein PhoH
IDM46_RS03525	COG0723	plastoquinol--plastocyanin reductase activity
IDM46_RS03530	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
IDM46_RS03535	COG2857	Cytochrome c1
IDM46_RS03540	COG0625	glutathione transferase activity
IDM46_RS03545	COG2969	positive regulation of protein catabolic process
IDM46_RS03570	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
IDM46_RS03585	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
IDM46_RS03590	COG1028	Short-chain dehydrogenase reductase Sdr
IDM46_RS03595	COG2095	MarC family integral membrane protein
IDM46_RS03605	COG1611	Belongs to the LOG family
IDM46_RS03610	COG4969	Belongs to the N-Me-Phe pilin family
IDM46_RS03640	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IDM46_RS03645	COG3685	Protein conserved in bacteria
IDM46_RS03665	COG0556	nucleotide-excision repair
IDM46_RS03675	COG1285	pathogenesis
IDM46_RS03685	COG3505	Type IV secretory pathway VirD4
IDM46_RS03700	COG3459	Glycosyltransferase 36 associated
IDM46_RS03705	COG0326	Molecular chaperone. Has ATPase activity
IDM46_RS03720	COG0531	amino acid
IDM46_RS03735	COG0513	Belongs to the DEAD box helicase family
IDM46_RS03740	COG1111	helicase
IDM46_RS03740	COG1205	dead DEAH box helicase
IDM46_RS03765	COG1793	dna ligase
IDM46_RS03770	COG1201	RNA secondary structure unwinding
IDM46_RS03820	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IDM46_RS03845	COG1132	(ABC) transporter
IDM46_RS03855	COG1704	LemA family
IDM46_RS03885	COG3267	Type II secretory pathway component ExeA
IDM46_RS03885	COG3409	Peptidoglycan-binding domain 1 protein
IDM46_RS03900	COG0667	Aldo Keto reductase
IDM46_RS03910	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IDM46_RS03955	COG1981	membrane
IDM46_RS03960	COG1785	Belongs to the alkaline phosphatase family
IDM46_RS03965	COG1301	dicarboxylic acid transport
IDM46_RS03980	COG0612	Peptidase, M16
IDM46_RS03985	COG0612	Peptidase, M16
IDM46_RS04000	COG0791	NLP P60 protein
IDM46_RS04005	COG0791	NLP P60 protein
IDM46_RS04010	COG1047	Peptidyl-prolyl cis-trans
IDM46_RS04045	COG0504	CTP synthase activity
IDM46_RS04050	COG2877	3-deoxy-8-phosphooctulonate synthase activity
IDM46_RS04055	COG0148	phosphopyruvate hydratase activity
IDM46_RS04070	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
IDM46_RS04090	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
IDM46_RS04100	COG3932	Exopolysaccharide synthesis, ExoD
IDM46_RS04115	COG1534	Rna-binding protein
IDM46_RS04120	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
IDM46_RS04125	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IDM46_RS04130	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
IDM46_RS04135	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IDM46_RS04140	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
IDM46_RS04145	COG1923	regulation of RNA biosynthetic process
IDM46_RS04150	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IDM46_RS04155	COG0330	HflC and HflK could
IDM46_RS04160	COG0330	HflC and HflK could
IDM46_RS04165	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
IDM46_RS04205	COG0640	Transcriptional regulator
IDM46_RS04215	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
IDM46_RS04260	COG1451	nucleotide metabolic process
IDM46_RS04270	COG2205	protein histidine kinase activity
IDM46_RS04275	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
IDM46_RS04280	COG0784	Response regulator, receiver
IDM46_RS04280	COG4191	Histidine kinase
IDM46_RS04290	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
IDM46_RS04305	COG0784	Response regulator, receiver
IDM46_RS04305	COG4191	Histidine kinase
IDM46_RS04330	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IDM46_RS04350	COG1289	transmembrane transporter activity
IDM46_RS04360	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IDM46_RS04365	COG0753	catalase activity
IDM46_RS04370	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
IDM46_RS04375	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IDM46_RS04375	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IDM46_RS04380	COG2814	Major facilitator Superfamily
IDM46_RS04390	COG2202	Pas domain
IDM46_RS04390	COG2205	protein histidine kinase activity
IDM46_RS04410	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
IDM46_RS04415	COG2894	cell division
IDM46_RS04430	COG4585	Histidine kinase
IDM46_RS04435	COG2197	response regulator
IDM46_RS04450	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
IDM46_RS04465	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
IDM46_RS04475	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
IDM46_RS04480	COG0745	RESPONSE REGULATOR receiver
IDM46_RS04485	COG2205	protein histidine kinase activity
IDM46_RS04490	COG4452	Inner membrane protein CreD
IDM46_RS04495	COG0671	phosphoesterase, PA-phosphatase related
IDM46_RS04500	COG0438	transferase activity, transferring glycosyl groups
IDM46_RS04545	COG2165	general secretion pathway protein
IDM46_RS04590	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
IDM46_RS04600	COG1024	Enoyl-CoA hydratase
IDM46_RS04670	COG1404	Belongs to the peptidase S8 family
IDM46_RS04680	COG0211	Belongs to the bacterial ribosomal protein bL27 family
IDM46_RS04690	COG0268	Binds directly to 16S ribosomal RNA
IDM46_RS04700	COG0196	riboflavin kinase activity
IDM46_RS04710	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
IDM46_RS04715	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
IDM46_RS04730	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IDM46_RS04735	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
IDM46_RS04740	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IDM46_RS04745	COG0228	four-way junction DNA binding
IDM46_RS04750	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
IDM46_RS04755	COG0336	Belongs to the RNA methyltransferase TrmD family
IDM46_RS04780	COG3706	GGDEF domain
IDM46_RS04790	COG1546	Belongs to the CinA family
IDM46_RS04795	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IDM46_RS04800	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IDM46_RS04805	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
IDM46_RS04810	COG2137	regulation of response to DNA damage stimulus
IDM46_RS04815	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IDM46_RS04820	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
IDM46_RS04840	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
IDM46_RS04850	COG0318	PFAM AMP-dependent synthetase and ligase
IDM46_RS04855	COG0367	asparagine synthase
IDM46_RS04885	COG0438	transferase activity, transferring glycosyl groups
IDM46_RS04915	COG0438	transferase activity, transferring glycosyl groups
IDM46_RS04915	COG0297	glycogen (starch) synthase activity
IDM46_RS04925	COG0318	PFAM AMP-dependent synthetase and ligase
IDM46_RS04930	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
IDM46_RS04985	COG0352	thiamine-phosphate diphosphorylase activity
IDM46_RS04985	COG0351	phosphomethylpyrimidine kinase
IDM46_RS04990	COG0659	secondary active sulfate transmembrane transporter activity
IDM46_RS04995	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
IDM46_RS05000	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
IDM46_RS05010	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IDM46_RS05020	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
IDM46_RS05030	COG0617	tRNA 3'-terminal CCA addition
IDM46_RS05035	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
IDM46_RS05040	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
IDM46_RS05045	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
IDM46_RS05050	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
IDM46_RS05055	COG0166	Belongs to the GPI family
IDM46_RS05060	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IDM46_RS05065	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
IDM46_RS05065	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IDM46_RS05075	COG0860	N-Acetylmuramoyl-L-alanine amidase
IDM46_RS05080	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
IDM46_RS05095	COG2878	Part of a membrane complex involved in electron transport
IDM46_RS05100	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IDM46_RS05100	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IDM46_RS05105	COG4206	TonB-dependent receptor
IDM46_RS05115	COG0489	protein tyrosine kinase activity
IDM46_RS05120	COG0717	Belongs to the dCTP deaminase family
IDM46_RS05130	COG0412	Dienelactone hydrolase
IDM46_RS05135	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IDM46_RS05140	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IDM46_RS05150	COG0433	COG0433 Predicted ATPase
IDM46_RS05160	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
IDM46_RS05165	COG0488	(ABC) transporter
IDM46_RS05210	COG1187	pseudouridine synthase activity
IDM46_RS05225	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IDM46_RS05230	COG0339	signal peptide processing
IDM46_RS05235	COG0386	Belongs to the glutathione peroxidase family
IDM46_RS05275	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IDM46_RS05285	COG2839	Protein conserved in bacteria
IDM46_RS05300	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
IDM46_RS05305	COG0084	hydrolase, TatD family'
IDM46_RS05320	COG1960	acyl-CoA dehydrogenase activity
IDM46_RS05330	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
IDM46_RS05400	COG2333	competence protein COMEC
IDM46_RS05400	COG0658	competence protein
IDM46_RS05405	COG0811	peptide transport
IDM46_RS05410	COG0848	biopolymer transport protein
IDM46_RS05420	COG1663	tetraacyldisaccharide 4'-kinase activity
IDM46_RS05425	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
IDM46_RS05455	COG4464	protein tyrosine phosphatase activity
IDM46_RS05460	COG1596	polysaccharide export
IDM46_RS05490	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
IDM46_RS05495	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
IDM46_RS05495	COG2755	lipolytic protein G-D-S-L family
IDM46_RS05520	COG0110	maltose O-acetyltransferase activity
IDM46_RS05545	COG0367	asparagine synthase
IDM46_RS05555	COG0438	transferase activity, transferring glycosyl groups
IDM46_RS05570	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IDM46_RS05580	COG2885	chlorophyll binding
IDM46_RS05580	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
IDM46_RS05610	COG0415	Belongs to the DNA photolyase family
IDM46_RS05620	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
IDM46_RS05640	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
IDM46_RS05645	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IDM46_RS05660	COG0069	glutamate synthase activity
IDM46_RS05670	COG1737	Transcriptional regulator
IDM46_RS05675	COG4948	Mandelate Racemase Muconate Lactonizing
IDM46_RS05695	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IDM46_RS05700	COG2323	membrane
IDM46_RS05710	COG3300	MHYT domain
IDM46_RS05710	COG5001	Diguanylate cyclase
IDM46_RS05730	COG1028	Short-chain dehydrogenase reductase Sdr
IDM46_RS05740	COG1199	ATP-dependent helicase activity
IDM46_RS05760	COG1194	a g-specific adenine glycosylase
IDM46_RS05770	COG0552	protein localization to endoplasmic reticulum
IDM46_RS05775	COG0742	ribosomal rna small subunit methyltransferase
IDM46_RS05790	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
IDM46_RS05805	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IDM46_RS05815	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
IDM46_RS05835	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
IDM46_RS05845	COG1840	ABC-type Fe3 transport system, periplasmic component
IDM46_RS05850	COG1178	ABC-type Fe3 transport system permease component
IDM46_RS05855	COG3842	ATPase activity
IDM46_RS05860	COG0343	queuine tRNA-ribosyltransferase activity
IDM46_RS05865	COG1862	Preprotein translocase
IDM46_RS05870	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IDM46_RS05895	COG5001	Diguanylate cyclase
IDM46_RS05895	COG3300	MHYT domain
IDM46_RS05905	COG1253	flavin adenine dinucleotide binding
IDM46_RS05915	COG0306	phosphate transporter
IDM46_RS05935	COG3590	peptidase
IDM46_RS05940	COG3590	peptidase
IDM46_RS05945	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IDM46_RS05945	COG0475	glutathione-regulated potassium exporter activity
IDM46_RS05950	COG0513	Belongs to the DEAD box helicase family
IDM46_RS05955	COG2815	serine threonine protein kinase
IDM46_RS05955	COG0515	serine threonine protein kinase
IDM46_RS05965	COG3118	belongs to the thioredoxin family
IDM46_RS05975	COG0495	leucyl-tRNA aminoacylation
IDM46_RS05990	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
IDM46_RS06000	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
IDM46_RS06010	COG2968	Membrane
IDM46_RS06015	COG0424	maF-like protein
IDM46_RS06030	COG0312	modulator of DNA gyrase
IDM46_RS06035	COG3028	Belongs to the UPF0307 family
IDM46_RS06040	COG0312	modulator of DNA gyrase
IDM46_RS06050	COG0142	geranyltranstransferase activity
IDM46_RS06055	COG1722	exodeoxyribonuclease VII activity
IDM46_RS06060	COG0037	tRNA processing
IDM46_RS06065	COG1902	pentaerythritol trinitrate reductase activity
IDM46_RS06110	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IDM46_RS06120	COG0750	zinc metalloprotease
IDM46_RS06125	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
IDM46_RS06130	COG0575	Belongs to the CDS family
IDM46_RS06155	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
IDM46_RS06160	COG0052	Belongs to the universal ribosomal protein uS2 family
IDM46_RS06190	COG0024	Methionine aminopeptidase
IDM46_RS06195	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
IDM46_RS06205	COG1393	Belongs to the ArsC family
IDM46_RS06210	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IDM46_RS06220	COG0367	asparagine synthase
IDM46_RS06240	COG0431	NADPH-dependent FMN reductase
IDM46_RS06250	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
IDM46_RS06260	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IDM46_RS06270	COG2072	flavoprotein involved in K transport
IDM46_RS06280	COG0557	exoribonuclease II activity
IDM46_RS06285	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IDM46_RS06300	COG3220	belongs to the UPF0276 family
IDM46_RS06310	COG0704	Plays a role in the regulation of phosphate uptake
IDM46_RS06325	COG0573	inorganic phosphate transmembrane transporter activity
IDM46_RS06350	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
IDM46_RS06355	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
IDM46_RS06360	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
IDM46_RS06375	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
IDM46_RS06380	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
IDM46_RS06395	COG0583	DNA-binding transcription factor activity
IDM46_RS06405	COG2197	response regulator
IDM46_RS06410	COG1530	ribonuclease E activity
IDM46_RS06425	COG0316	Belongs to the HesB IscA family
IDM46_RS06425	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
IDM46_RS06445	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IDM46_RS06465	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IDM46_RS06470	COG2957	Belongs to the agmatine deiminase family
IDM46_RS06485	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
IDM46_RS06490	COG0539	negative regulation of cytoplasmic translation
IDM46_RS06495	COG0776	regulation of translation
IDM46_RS06505	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
IDM46_RS06535	COG0183	Belongs to the thiolase family
IDM46_RS06540	COG1250	3-hydroxyacyl-CoA dehydrogenase
IDM46_RS06540	COG1024	Enoyl-CoA hydratase
IDM46_RS06550	COG0105	UTP biosynthetic process
IDM46_RS06555	COG0820	rRNA (adenine-C2-)-methyltransferase activity
IDM46_RS06565	COG1426	Protein conserved in bacteria
IDM46_RS06575	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IDM46_RS06585	COG0746	molybdenum cofactor guanylyltransferase activity
IDM46_RS06590	COG0303	'Molybdopterin
IDM46_RS06605	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
IDM46_RS06620	COG0519	Catalyzes the synthesis of GMP from XMP
IDM46_RS06620	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IDM46_RS06630	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
IDM46_RS06645	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
IDM46_RS06750	COG3278	Belongs to the heme-copper respiratory oxidase family
IDM46_RS06765	COG2010	Cytochrome c
IDM46_RS06785	COG2217	Heavy metal translocating P-type atpase
IDM46_RS06800	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
IDM46_RS06815	COG1674	ftsk spoiiie
IDM46_RS06820	COG0686	Belongs to the AlaDH PNT family
IDM46_RS06825	COG0492	ferredoxin-NADP+ reductase activity
IDM46_RS06835	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
IDM46_RS06845	COG0542	response to heat
IDM46_RS06860	COG0482	sulfurtransferase activity
IDM46_RS06865	COG2915	High frequency lysogenization protein hflD homolog
IDM46_RS06900	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
IDM46_RS06910	COG0318	PFAM AMP-dependent synthetase and ligase
IDM46_RS06915	COG1024	Enoyl-CoA hydratase
IDM46_RS06945	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
IDM46_RS06955	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IDM46_RS06960	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
IDM46_RS06965	COG0505	Belongs to the CarA family
IDM46_RS06970	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
IDM46_RS06975	COG0484	heat shock protein binding
IDM46_RS06980	COG0443	Heat shock 70 kDa protein
IDM46_RS06985	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
IDM46_RS06990	COG1420	regulation of RNA biosynthetic process
IDM46_RS07000	COG0735	belongs to the Fur family
IDM46_RS07005	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IDM46_RS07020	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
IDM46_RS07025	COG2202	Pas domain
IDM46_RS07025	COG2205	protein histidine kinase activity
IDM46_RS07040	COG0784	Response regulator, receiver
IDM46_RS07040	COG4191	Histidine kinase
IDM46_RS07045	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IDM46_RS07055	COG2885	chlorophyll binding
IDM46_RS07060	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
IDM46_RS07065	COG0305	Participates in initiation and elongation during chromosome replication
IDM46_RS07070	COG0359	binds to the 23S rRNA
IDM46_RS07075	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
IDM46_RS07080	COG0360	Binds together with S18 to 16S ribosomal RNA
IDM46_RS07090	COG0316	Belongs to the HesB IscA family
IDM46_RS07095	COG0017	Asparaginyl-tRNA synthetase
IDM46_RS07120	COG0288	reversible hydration of carbon dioxide
IDM46_RS07140	COG3844	kynureninase activity
IDM46_RS07145	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IDM46_RS07150	COG2925	Exonuclease
IDM46_RS07170	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
IDM46_RS07175	COG2902	Dehydrogenase
IDM46_RS07180	COG1960	acyl-CoA dehydrogenase activity
IDM46_RS07185	COG2226	methyltransferase
IDM46_RS07210	COG2900	Belongs to the SlyX family
IDM46_RS07225	COG0545	Peptidyl-prolyl cis-trans isomerase
IDM46_RS07235	COG1725	Transcriptional regulator
IDM46_RS07240	COG1131	(ABC) transporter
IDM46_RS07260	COG2850	peptidyl-arginine hydroxylation
IDM46_RS07270	COG0567	Dehydrogenase, E1 component
IDM46_RS07275	COG0508	dehydrogenase complex catalyzes the overall conversion of
IDM46_RS07290	COG0604	alcohol dehydrogenase
IDM46_RS07310	COG4953	penicillin-binding protein 1C
IDM46_RS07315	COG2373	Large extracellular alpha-helical protein
IDM46_RS07325	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
IDM46_RS07330	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
IDM46_RS07335	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IDM46_RS07350	COG1793	dna ligase
IDM46_RS07355	COG3842	ATPase activity
IDM46_RS07360	COG2723	6-phospho-beta-galactosidase activity
IDM46_RS07370	COG0189	ligase activity
IDM46_RS07390	COG0395	ABC-type sugar transport system, permease component
IDM46_RS07395	COG1175	transmembrane transport
IDM46_RS07415	COG2350	Protein conserved in bacteria
IDM46_RS07420	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
IDM46_RS07430	COG1187	pseudouridine synthase activity
IDM46_RS07445	COG0436	Aminotransferase
IDM46_RS07480	COG1138	Cytochrome C-type biogenesis protein
IDM46_RS07500	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IDM46_RS07540	COG3243	poly(R)-hydroxyalkanoic acid synthase
IDM46_RS07550	COG1183	phosphatidylcholine synthase activity
IDM46_RS07560	COG1028	Short-chain dehydrogenase reductase Sdr
IDM46_RS07575	COG2205	protein histidine kinase activity
IDM46_RS07580	COG4771	TonB-dependent receptor
IDM46_RS07585	COG2610	gluconate transmembrane transporter activity
IDM46_RS07600	COG1185	polyribonucleotide nucleotidyltransferase activity
IDM46_RS07605	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
IDM46_RS07615	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
IDM46_RS07625	COG0195	Participates in both transcription termination and antitermination
IDM46_RS07630	COG0779	Required for maturation of 30S ribosomal subunits
IDM46_RS07640	COG1007	ATP synthesis coupled electron transport
IDM46_RS07670	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
IDM46_RS07680	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
IDM46_RS07685	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
IDM46_RS07690	COG0649	NAD binding
IDM46_RS07695	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IDM46_RS07700	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IDM46_RS07705	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IDM46_RS07720	COG0149	triose-phosphate isomerase activity
IDM46_RS07735	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
IDM46_RS07740	COG0159	tryptophan synthase activity
IDM46_RS07745	COG0133	tryptophan synthase activity
IDM46_RS07750	COG0135	phosphoribosylanthranilate isomerase activity
IDM46_RS07755	COG0101	tRNA pseudouridine synthase activity
IDM46_RS07765	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
IDM46_RS07775	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
IDM46_RS07780	COG2890	protein-(glutamine-N5) methyltransferase activity
IDM46_RS07785	COG1999	signal sequence binding
IDM46_RS07790	COG0688	phosphatidylethanolamine metabolic process
IDM46_RS07805	COG1054	Belongs to the UPF0176 family
IDM46_RS07810	COG2081	HI0933 family
IDM46_RS07860	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
IDM46_RS07900	COG2824	Alkylphosphonate utilization operon protein PhnA
IDM46_RS07905	COG5487	UPF0391 membrane protein
IDM46_RS07920	COG1028	Short-chain dehydrogenase reductase Sdr
IDM46_RS07995	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
IDM46_RS08010	COG2860	membrane
IDM46_RS08020	COG0564	pseudouridine synthase activity
IDM46_RS08025	COG1028	Short-chain dehydrogenase reductase Sdr
IDM46_RS08025	COG3321	synthase
IDM46_RS08025	COG0604	alcohol dehydrogenase
IDM46_RS08030	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
IDM46_RS08040	COG3384	dioxygenase
IDM46_RS08045	COG1028	Short-chain dehydrogenase reductase Sdr
IDM46_RS08070	COG0204	Acyl-transferase
IDM46_RS08085	COG3706	GGDEF domain
IDM46_RS08100	COG0653	protein targeting
IDM46_RS08105	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
IDM46_RS08150	COG1573	uracil-dna glycosylase
IDM46_RS08160	COG1187	pseudouridine synthase activity
IDM46_RS08175	COG1619	proteins homologs of microcin C7 resistance protein MccF
IDM46_RS08180	COG3665	Urea carboxylase-associated protein
IDM46_RS08205	COG3655	Transcriptional regulator
IDM46_RS08215	COG5507	3-demethylubiquinone-9 3-methyltransferase
IDM46_RS08225	COG4807	Protein conserved in bacteria
IDM46_RS08230	COG0584	glycerophosphoryl diester phosphodiesterase
IDM46_RS08235	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
IDM46_RS08265	COG2319	Wd-40 repeat
IDM46_RS08285	COG1902	pentaerythritol trinitrate reductase activity
IDM46_RS08290	COG0693	protein deglycase activity
IDM46_RS08295	COG4548	von Willebrand factor, type A
IDM46_RS08300	COG0714	Associated with various cellular activities
IDM46_RS08305	COG3256	nitric oxide reductase
IDM46_RS08310	COG2010	Cytochrome c
IDM46_RS08350	COG0861	Integral membrane protein TerC family
IDM46_RS08370	COG2944	sequence-specific DNA binding
IDM46_RS08410	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
IDM46_RS08425	COG1703	isobutyryl-CoA mutase activity
IDM46_RS08425	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IDM46_RS08425	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IDM46_RS08430	COG4251	negative regulation of phosphorylation
IDM46_RS08445	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IDM46_RS08455	COG1960	acyl-CoA dehydrogenase activity
IDM46_RS08465	COG0183	Belongs to the thiolase family
IDM46_RS08480	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IDM46_RS08505	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
IDM46_RS08505	COG1918	ferrous iron import across plasma membrane
IDM46_RS08515	COG1024	Enoyl-CoA hydratase
IDM46_RS08540	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IDM46_RS08555	COG0277	FAD linked oxidase domain protein
IDM46_RS08560	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IDM46_RS08570	COG0531	amino acid
IDM46_RS08575	COG0531	amino acid
IDM46_RS08580	COG0235	Class ii aldolase
IDM46_RS08590	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
IDM46_RS08605	COG0140	phosphoribosyl-ATP diphosphatase activity
IDM46_RS08605	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
IDM46_RS08610	COG0107	imidazoleglycerol-phosphate synthase activity
IDM46_RS08625	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
IDM46_RS08625	COG0131	Imidazoleglycerol-phosphate dehydratase
IDM46_RS08630	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IDM46_RS08635	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
IDM46_RS08640	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
IDM46_RS08665	COG2986	histidine ammonia-lyase
IDM46_RS08670	COG0124	histidyl-tRNA synthetase
IDM46_RS08690	COG0165	Argininosuccinate lyase
IDM46_RS08700	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IDM46_RS08705	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IDM46_RS08710	COG0137	argininosuccinate synthase activity
IDM46_RS08715	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
IDM46_RS08750	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IDM46_RS08760	COG1469	GTP cyclohydrolase I activity
IDM46_RS08775	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IDM46_RS08780	COG0402	S-adenosylhomocysteine deaminase activity
IDM46_RS08790	COG1509	lysine 2,3-aminomutase activity
IDM46_RS08795	COG5001	Diguanylate cyclase
IDM46_RS08795	COG3300	MHYT domain
IDM46_RS08800	COG0501	Belongs to the peptidase M48B family
IDM46_RS08810	COG1028	Short-chain dehydrogenase reductase Sdr
IDM46_RS08815	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
IDM46_RS08820	COG1028	Short-chain dehydrogenase reductase Sdr
IDM46_RS08850	COG1012	belongs to the aldehyde dehydrogenase family
IDM46_RS08860	COG0812	UDP-N-acetylmuramate dehydrogenase activity
IDM46_RS08870	COG1404	Belongs to the peptidase S8 family
IDM46_RS08875	COG0671	phosphoesterase, PA-phosphatase related
IDM46_RS08890	COG1012	belongs to the aldehyde dehydrogenase family
IDM46_RS08895	COG2304	oxidoreductase activity
IDM46_RS08900	COG5001	Diguanylate cyclase
IDM46_RS08905	COG1595	DNA-templated transcription, initiation
IDM46_RS08920	COG1132	(ABC) transporter
IDM46_RS08925	COG1960	acyl-CoA dehydrogenase activity
IDM46_RS08965	COG3590	peptidase
IDM46_RS08975	COG1278	Cold shock
IDM46_RS08980	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
IDM46_RS08985	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
IDM46_RS08990	COG1472	Belongs to the glycosyl hydrolase 3 family
IDM46_RS08995	COG2954	triphosphatase activity
IDM46_RS09000	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
IDM46_RS09020	COG1381	Involved in DNA repair and RecF pathway recombination
IDM46_RS09045	COG0481	GTPase activity
IDM46_RS09050	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IDM46_RS09065	COG1250	3-hydroxyacyl-CoA dehydrogenase
IDM46_RS09065	COG1024	Enoyl-CoA hydratase
IDM46_RS09085	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
IDM46_RS09090	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
IDM46_RS09095	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IDM46_RS09110	COG1028	Short-chain dehydrogenase reductase Sdr
IDM46_RS09120	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IDM46_RS09125	COG0333	Belongs to the bacterial ribosomal protein bL32 family
IDM46_RS09130	COG1399	metal-binding, possibly nucleic acid-binding protein
IDM46_RS09140	COG0424	maF-like protein
IDM46_RS09150	COG0714	Associated with various cellular activities
IDM46_RS09170	COG0537	adenosine 5'-monophosphoramidase activity
IDM46_RS09185	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
IDM46_RS09200	COG0314	molybdopterin synthase activity
IDM46_RS09210	COG0315	cyclic pyranopterin monophosphate synthase activity
IDM46_RS09215	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
IDM46_RS09220	COG1234	tRNA 3'-trailer cleavage
IDM46_RS09225	COG3642	lipopolysaccharide core region biosynthetic process
IDM46_RS09230	COG0859	PFAM glycosyl transferase family 9
IDM46_RS09245	COG0631	protein serine/threonine phosphatase activity
IDM46_RS09250	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IDM46_RS09265	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IDM46_RS09280	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IDM46_RS09305	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
IDM46_RS09315	COG0544	peptidyl-prolyl cis-trans isomerase activity
IDM46_RS09355	COG0473	3-isopropylmalate dehydrogenase activity
IDM46_RS09360	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IDM46_RS09370	COG4783	chaperone-mediated protein folding
IDM46_RS09390	COG0248	Ppx GppA phosphatase
IDM46_RS09405	COG1960	acyl-CoA dehydrogenase activity
IDM46_RS09455	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
IDM46_RS09460	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
IDM46_RS09470	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
IDM46_RS09475	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
IDM46_RS09495	COG3702	type iv secretory pathway
IDM46_RS09545	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IDM46_RS09555	COG1228	amidohydrolase
IDM46_RS09580	COG0735	belongs to the Fur family
IDM46_RS09590	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IDM46_RS09595	COG2833	Protein of unknown function (DUF455)
IDM46_RS09610	COG0285	dihydrofolate synthase activity
IDM46_RS09635	COG0156	8-amino-7-oxononanoate synthase activity
IDM46_RS09655	COG1902	pentaerythritol trinitrate reductase activity
IDM46_RS09655	COG0446	pyridine nucleotide-disulphide oxidoreductase
IDM46_RS09665	COG0625	glutathione transferase activity
IDM46_RS09680	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IDM46_RS09685	COG0039	L-malate dehydrogenase activity
IDM46_RS09695	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IDM46_RS09700	COG1217	gtp-binding protein TYPA
IDM46_RS09705	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
IDM46_RS09725	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
IDM46_RS09730	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
IDM46_RS09740	COG0201	protein transport
IDM46_RS09745	COG0200	Binds to the 23S rRNA
IDM46_RS09760	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
IDM46_RS09775	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
IDM46_RS09780	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
IDM46_RS09785	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
IDM46_RS09795	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
IDM46_RS09800	COG0255	Belongs to the universal ribosomal protein uL29 family
IDM46_RS09805	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
IDM46_RS09810	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
IDM46_RS09825	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
IDM46_RS09830	COG0089	rRNA binding
IDM46_RS09840	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
IDM46_RS09845	COG0051	transcription antitermination factor activity, RNA binding
IDM46_RS09850	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
IDM46_RS09855	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IDM46_RS09860	COG0049	tRNA binding
IDM46_RS09865	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
IDM46_RS09870	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
IDM46_RS09880	COG0222	ribosome binding
IDM46_RS09885	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
IDM46_RS09895	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
IDM46_RS09900	COG0250	Participates in transcription elongation, termination and antitermination
IDM46_RS09905	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IDM46_RS09915	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
IDM46_RS09940	COG0193	aminoacyl-tRNA hydrolase activity
IDM46_RS09950	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
IDM46_RS09960	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
IDM46_RS09965	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
IDM46_RS09980	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
IDM46_RS09990	COG0521	Mo-molybdopterin cofactor biosynthetic process
IDM46_RS10000	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IDM46_RS10005	COG1295	ribonuclease BN
IDM46_RS10020	COG0252	asparaginase activity
IDM46_RS10035	COG1404	Belongs to the peptidase S8 family
IDM46_RS10050	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
IDM46_RS10075	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
IDM46_RS10095	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IDM46_RS10095	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IDM46_RS10110	COG2890	protein-(glutamine-N5) methyltransferase activity
IDM46_RS10120	COG3634	alkyl hydroperoxide reductase activity
IDM46_RS10125	COG0583	DNA-binding transcription factor activity
IDM46_RS10155	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
IDM46_RS10160	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IDM46_RS10165	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IDM46_RS10175	COG2096	Adenosyltransferase
IDM46_RS10200	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IDM46_RS10205	COG2967	ApaG domain
IDM46_RS10210	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
IDM46_RS10230	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
IDM46_RS10235	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
IDM46_RS10240	COG0861	Integral membrane protein TerC family
IDM46_RS10245	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
IDM46_RS10255	COG3584	3D domain protein
IDM46_RS10255	COG1388	LysM domain
IDM46_RS10260	COG1446	asparaginase
IDM46_RS10265	COG1136	(ABC) transporter
IDM46_RS10265	COG0577	efflux transmembrane transporter activity
IDM46_RS10270	COG0577	efflux transmembrane transporter activity
IDM46_RS10270	COG1136	(ABC) transporter
IDM46_RS10275	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IDM46_RS10280	COG0642	Histidine kinase
IDM46_RS10295	COG3956	TIGRFAM MazG family protein
IDM46_RS10305	COG0494	nUDIX hydrolase
IDM46_RS10315	COG1385	rRNA (uridine-N3-)-methyltransferase activity
IDM46_RS10330	COG2198	Histidine kinase
IDM46_RS10330	COG0784	Response regulator, receiver
IDM46_RS10330	COG0643	Histidine kinase
IDM46_RS10355	COG0840	transmembrane signaling receptor activity
IDM46_RS10375	COG0189	ligase activity
IDM46_RS10385	COG1214	PFAM Peptidase M22, glycoprotease
IDM46_RS10390	COG1199	ATP-dependent helicase activity
IDM46_RS10400	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IDM46_RS10405	COG0463	Glycosyl transferase, family 2
IDM46_RS10415	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IDM46_RS10425	COG1643	Atp-dependent helicase
IDM46_RS10430	COG0783	Belongs to the Dps family
IDM46_RS10435	COG0514	ATP-dependent DNA helicase (RecQ)
IDM46_RS10440	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
IDM46_RS10450	COG5001	Diguanylate cyclase
IDM46_RS10450	COG3300	MHYT domain
IDM46_RS10470	COG3546	catalase activity
IDM46_RS10475	COG1063	alcohol dehydrogenase
IDM46_RS10480	COG3685	Protein conserved in bacteria
IDM46_RS10495	COG0602	queuosine metabolic process
IDM46_RS10505	COG2885	chlorophyll binding
IDM46_RS10530	COG0824	Thioesterase
IDM46_RS10535	COG2255	four-way junction helicase activity
IDM46_RS10545	COG0632	four-way junction helicase activity
IDM46_RS10555	COG0217	transcriptional regulatory protein
IDM46_RS10590	COG0488	(ABC) transporter
IDM46_RS10600	COG4771	TonB-dependent receptor
IDM46_RS10605	COG4651	solute:proton antiporter activity
IDM46_RS10605	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IDM46_RS10610	COG0542	response to heat
IDM46_RS10615	COG1877	trehalose-phosphatase activity
IDM46_RS10620	COG3387	PFAM Glycoside hydrolase 15-related
IDM46_RS10625	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
IDM46_RS10635	COG1496	oxidoreductase activity
IDM46_RS10640	COG0564	pseudouridine synthase activity
IDM46_RS10645	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IDM46_RS10650	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IDM46_RS10650	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
IDM46_RS10670	COG0045	succinate-CoA ligase (ADP-forming) activity
IDM46_RS10710	COG2076	Multidrug Resistance protein
IDM46_RS10715	COG4969	Belongs to the N-Me-Phe pilin family
IDM46_RS10770	COG1216	Glycosyl transferase, family 2
IDM46_RS10785	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
IDM46_RS10820	COG0653	protein targeting
IDM46_RS10825	COG0739	heme binding
IDM46_RS10850	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
IDM46_RS10855	COG1181	Belongs to the D-alanine--D-alanine ligase family
IDM46_RS10875	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IDM46_RS10890	COG3116	cell division
IDM46_RS10895	COG0275	rRNA processing
IDM46_RS10925	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IDM46_RS10930	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
IDM46_RS10945	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IDM46_RS10945	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IDM46_RS10960	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IDM46_RS10970	COG0488	(ABC) transporter
IDM46_RS10975	COG0284	orotidine-5'-phosphate decarboxylase activity
IDM46_RS10995	COG1450	Type ii and iii secretion system protein
IDM46_RS11010	COG3166	PFAM Fimbrial assembly family protein
IDM46_RS11015	COG3156	type II secretion system protein K
IDM46_RS11020	COG4795	General secretion pathway protein
IDM46_RS11025	COG2165	general secretion pathway protein
IDM46_RS11030	COG4970	Tfp pilus assembly protein FimT
IDM46_RS11035	COG2165	general secretion pathway protein
IDM46_RS11040	COG1459	type II secretion system
IDM46_RS11045	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IDM46_RS11055	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IDM46_RS11055	COG0047	phosphoribosylformylglycinamidine synthase activity
IDM46_RS11060	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IDM46_RS11065	COG4974	Belongs to the 'phage' integrase family
IDM46_RS11075	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
IDM46_RS11080	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IDM46_RS11095	COG0725	ABC transporter, periplasmic molybdate-binding protein
IDM46_RS11100	COG4149	molybdate abc transporter
IDM46_RS11120	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IDM46_RS11125	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
IDM46_RS11130	COG1301	dicarboxylic acid transport
IDM46_RS11160	COG0714	Associated with various cellular activities
IDM46_RS11200	COG0372	Belongs to the citrate synthase family
IDM46_RS11205	COG0254	rRNA binding
IDM46_RS11215	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IDM46_RS11225	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IDM46_RS11230	COG1758	RNA polymerase activity
IDM46_RS11240	COG1561	YicC-like family, N-terminal region
IDM46_RS11245	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
IDM46_RS11255	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IDM46_RS11270	COG0006	proline dipeptidase activity
IDM46_RS11275	COG0006	proline dipeptidase activity
IDM46_RS11305	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
IDM46_RS11370	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
IDM46_RS11375	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IDM46_RS11380	COG1028	Short-chain dehydrogenase reductase Sdr
IDM46_RS11390	COG0671	phosphoesterase, PA-phosphatase related
IDM46_RS11400	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IDM46_RS11420	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
IDM46_RS11435	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
IDM46_RS11450	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
IDM46_RS11470	COG1309	transcriptional regulator
IDM46_RS11475	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IDM46_RS11480	COG1538	Outer membrane efflux protein
IDM46_RS11485	COG1519	Transferase
IDM46_RS11490	COG1560	Kdo2-lipid A biosynthetic process
IDM46_RS11515	COG0778	Nitroreductase
IDM46_RS11540	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IDM46_RS11540	COG2111	Na H antiporter
IDM46_RS11545	COG1006	Multisubunit Na H antiporter MnhC subunit
IDM46_RS11550	COG0651	ATP synthesis coupled electron transport
IDM46_RS11560	COG2212	antiporter activity
IDM46_RS11565	COG1320	monovalent cation:proton antiporter activity
IDM46_RS11575	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
IDM46_RS11590	COG0457	Tetratricopeptide repeat
IDM46_RS11600	COG3104	oligopeptide transport
IDM46_RS11610	COG3483	tryptophan 2,3-dioxygenase activity
IDM46_RS11650	COG0180	Tryptophanyl-tRNA synthetase
IDM46_RS11655	COG3237	CsbD-like
IDM46_RS11685	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
IDM46_RS11725	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IDM46_RS11730	COG1607	acyl-coa hydrolase
IDM46_RS11740	COG3015	lipoprotein NlpE involved in copper resistance
IDM46_RS11755	COG2133	pyrroloquinoline quinone binding
IDM46_RS11810	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IDM46_RS11830	COG0628	permease
IDM46_RS11840	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IDM46_RS11845	COG2197	response regulator
IDM46_RS11850	COG4585	Histidine kinase
IDM46_RS11855	COG1228	amidohydrolase
IDM46_RS11865	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IDM46_RS11870	COG1136	(ABC) transporter
IDM46_RS11875	COG0577	efflux transmembrane transporter activity
IDM46_RS11900	COG0697	spore germination
IDM46_RS11920	COG2921	Belongs to the UPF0250 family
IDM46_RS11925	COG1686	Belongs to the peptidase S11 family
IDM46_RS11930	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
IDM46_RS11935	COG2951	lytic endotransglycosylase activity
IDM46_RS11940	COG0772	Belongs to the SEDS family
IDM46_RS11945	COG0768	penicillin binding
IDM46_RS11955	COG1792	Involved in formation and maintenance of cell shape
IDM46_RS11960	COG1077	Cell shape determining protein MreB Mrl
IDM46_RS11965	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IDM46_RS11980	COG0308	aminopeptidase N
IDM46_RS11985	COG2226	methyltransferase
IDM46_RS12005	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
IDM46_RS12040	COG2832	Protein of unknown function (DUF454)
IDM46_RS12050	COG1505	serine-type exopeptidase activity
IDM46_RS12065	COG0243	molybdopterin cofactor binding
IDM46_RS12070	COG0471	metal ion transport
IDM46_RS12070	COG3273	potassium ion transport
IDM46_RS12075	COG0437	4 iron, 4 sulfur cluster binding
IDM46_RS12080	COG3302	dmso reductase anchor subunit
IDM46_RS12090	COG0181	hydroxymethylbilane synthase activity
IDM46_RS12095	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IDM46_RS12110	COG3275	phosphorelay sensor kinase activity
IDM46_RS12130	COG2943	transferase activity, transferring hexosyl groups
IDM46_RS12135	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
IDM46_RS12145	COG1538	Outer membrane efflux protein
IDM46_RS12150	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IDM46_RS12270	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
IDM46_RS12285	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
IDM46_RS12300	COG2003	Belongs to the UPF0758 family
IDM46_RS12310	COG5377	YqaJ viral recombinase family
IDM46_RS12330	COG1401	restriction endodeoxyribonuclease activity
IDM46_RS12330	COG1401	restriction endodeoxyribonuclease activity
IDM46_RS12455	COG0582	viral genome integration into host DNA
IDM46_RS12470	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
IDM46_RS12475	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IDM46_RS12480	COG1490	D-aminoacyl-tRNA deacylase activity
IDM46_RS12515	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
IDM46_RS12520	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IDM46_RS12520	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
IDM46_RS12530	COG0242	peptide deformylase activity
IDM46_RS12540	COG0758	DNA mediated transformation
IDM46_RS12545	COG2922	Belongs to the Smg family
IDM46_RS12550	COG1754	DNA topoisomerase type I activity
IDM46_RS12550	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IDM46_RS12555	COG0009	L-threonylcarbamoyladenylate synthase
IDM46_RS12570	COG0754	glutathionylspermidine amidase activity
IDM46_RS12580	COG3766	membrane
IDM46_RS12600	COG1028	Short-chain dehydrogenase reductase Sdr
IDM46_RS12605	COG0616	signal peptide processing
IDM46_RS12610	COG0534	Mate efflux family protein
IDM46_RS12630	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
IDM46_RS12640	COG0428	transporter
IDM46_RS12655	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
IDM46_RS12660	COG2201	protein-glutamate methylesterase activity
IDM46_RS12665	COG2177	Part of the ABC transporter FtsEX involved in
IDM46_RS12670	COG2884	Cell division ATP-binding protein ftsE
IDM46_RS12680	COG3118	belongs to the thioredoxin family
IDM46_RS12685	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
IDM46_RS12705	COG3100	YcgL domain-containing protein
IDM46_RS12710	COG1294	oxidase, subunit
IDM46_RS12715	COG1271	oxidase subunit
IDM46_RS12720	COG0823	Involved in the tonB-independent uptake of proteins
IDM46_RS12720	COG1506	peptidase
IDM46_RS12720	COG4946	Tricorn protease homolog
IDM46_RS12725	COG0408	coproporphyrinogen oxidase activity
IDM46_RS12755	COG1971	Probably functions as a manganese efflux pump
IDM46_RS12765	COG0210	DNA helicase
IDM46_RS12780	COG0625	glutathione transferase activity
IDM46_RS12795	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IDM46_RS12805	COG0463	Glycosyl transferase, family 2
IDM46_RS12815	COG0475	glutathione-regulated potassium exporter activity
IDM46_RS12825	COG1028	Short-chain dehydrogenase reductase Sdr
IDM46_RS12850	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IDM46_RS12855	COG0204	Acyl-transferase
IDM46_RS12875	COG0251	oxidation-reduction process
IDM46_RS12885	COG1404	Belongs to the peptidase S8 family
IDM46_RS12900	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
IDM46_RS12925	COG0357	Ribosomal RNA small subunit methyltransferase G
IDM46_RS12930	COG1192	Involved in chromosome partitioning
IDM46_RS12935	COG1475	DNA binding
IDM46_RS12940	COG0227	Belongs to the bacterial ribosomal protein bL28 family
IDM46_RS12950	COG2205	protein histidine kinase activity
IDM46_RS12980	COG0477	Major facilitator Superfamily
IDM46_RS12995	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IDM46_RS13005	COG2815	serine threonine protein kinase
IDM46_RS13005	COG0515	serine threonine protein kinase
IDM46_RS13015	COG0210	DNA helicase
IDM46_RS13020	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
IDM46_RS13065	COG1196	nuclear chromosome segregation
IDM46_RS13065	COG0739	heme binding
IDM46_RS13065	COG0741	lytic transglycosylase activity
IDM46_RS13115	COG4789	Type iii secretion
IDM46_RS13130	COG4566	intracellular signal transduction
IDM46_RS13135	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
IDM46_RS13150	COG1987	bacterial-type flagellum assembly
IDM46_RS13160	COG4792	protein secretion
IDM46_RS13180	COG2937	Belongs to the GPAT DAPAT family
IDM46_RS13190	COG0037	tRNA processing
IDM46_RS13195	COG2974	May be involved in recombination
IDM46_RS13210	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
IDM46_RS13225	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IDM46_RS13245	COG0519	Catalyzes the synthesis of GMP from XMP
IDM46_RS13245	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IDM46_RS13250	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IDM46_RS13255	COG0752	glycyl-tRNA synthetase alpha subunit
IDM46_RS13265	COG0729	surface antigen
IDM46_RS13285	COG2183	response to ionizing radiation
IDM46_RS13305	COG0071	Belongs to the small heat shock protein (HSP20) family
IDM46_RS13320	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IDM46_RS13340	COG2267	carboxylic ester hydrolase activity
IDM46_RS13345	COG0697	spore germination
IDM46_RS13350	COG0156	8-amino-7-oxononanoate synthase activity
IDM46_RS13355	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
IDM46_RS13360	COG1040	competence protein
IDM46_RS13400	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
IDM46_RS13410	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IDM46_RS13415	COG1473	amidohydrolase
IDM46_RS13425	COG1652	LysM domain
IDM46_RS13440	COG1187	pseudouridine synthase activity
IDM46_RS13455	COG1643	Atp-dependent helicase
IDM46_RS13465	COG3047	cAMP biosynthetic process
IDM46_RS13465	COG2885	chlorophyll binding
IDM46_RS13475	COG0842	Transport permease protein
IDM46_RS13480	COG1131	(ABC) transporter
IDM46_RS13485	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
IDM46_RS13505	COG4555	ABC transporter
IDM46_RS13510	COG1668	transmembrane transport