locus-tag	class	description
VV02_RS00025	COG0667	Aldo Keto reductase
VV02_RS00030	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
VV02_RS00035	COG1234	tRNA 3'-trailer cleavage
VV02_RS00065	COG0640	Transcriptional regulator
VV02_RS00085	COG2066	Belongs to the glutaminase family
VV02_RS00100	COG1804	L-carnitine dehydratase bile acid-inducible protein F
VV02_RS00105	COG1024	Enoyl-CoA hydratase
VV02_RS00105	COG1250	3-hydroxyacyl-CoA dehydrogenase
VV02_RS00110	COG0183	Belongs to the thiolase family
VV02_RS00130	COG4941	Belongs to the sigma-70 factor family
VV02_RS00140	COG0745	RESPONSE REGULATOR receiver
VV02_RS00160	COG0384	phenazine biosynthesis protein PhzF
VV02_RS00175	COG0477	Major facilitator Superfamily
VV02_RS00180	COG1725	Transcriptional regulator
VV02_RS00205	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
VV02_RS00215	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
VV02_RS00230	COG0662	Cupin 2, conserved barrel domain protein
VV02_RS00235	COG1162	GTPase activity
VV02_RS00275	COG1937	Protein conserved in bacteria
VV02_RS00310	COG1472	Belongs to the glycosyl hydrolase 3 family
VV02_RS00320	COG0657	acetylesterase activity
VV02_RS00405	COG0386	Belongs to the glutathione peroxidase family
VV02_RS00420	COG2409	Drug exporters of the RND superfamily
VV02_RS00470	COG1846	Transcriptional regulator
VV02_RS00495	COG1028	Short-chain dehydrogenase reductase Sdr
VV02_RS00495	COG3347	Dehydrogenase
VV02_RS00510	COG1172	Belongs to the binding-protein-dependent transport system permease family
VV02_RS00515	COG1129	ABC transporter
VV02_RS00520	COG1879	ABC-type sugar transport system periplasmic component
VV02_RS00530	COG1349	DNA-binding transcription factor activity
VV02_RS00585	COG1175	transmembrane transport
VV02_RS00590	COG0395	ABC-type sugar transport system, permease component
VV02_RS00595	COG1486	melibiose metabolic process
VV02_RS00670	COG3707	response regulator
VV02_RS00675	COG1191	sigma factor activity
VV02_RS00715	COG4941	Belongs to the sigma-70 factor family
VV02_RS00740	COG1309	transcriptional regulator
VV02_RS00775	COG0596	Alpha beta hydrolase
VV02_RS00785	COG2226	methyltransferase
VV02_RS00880	COG2226	methyltransferase
VV02_RS00895	COG0823	Involved in the tonB-independent uptake of proteins
VV02_RS00920	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VV02_RS00950	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
VV02_RS00970	COG1131	(ABC) transporter
VV02_RS00975	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
VV02_RS00985	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
VV02_RS01000	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
VV02_RS01015	COG3511	phospholipase C
VV02_RS01025	COG0739	heme binding
VV02_RS01025	COG0741	lytic transglycosylase activity
VV02_RS01025	COG1196	nuclear chromosome segregation
VV02_RS01050	COG0318	PFAM AMP-dependent synthetase and ligase
VV02_RS01065	COG2827	Endonuclease containing a URI domain
VV02_RS01070	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
VV02_RS01075	COG1737	Transcriptional regulator
VV02_RS01085	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
VV02_RS01095	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
VV02_RS01110	COG1649	PFAM Uncharacterised BCR, COG1649
VV02_RS01125	COG0088	Forms part of the polypeptide exit tunnel
VV02_RS01150	COG3152	Membrane
VV02_RS01160	COG0352	thiamine-phosphate diphosphorylase activity
VV02_RS01165	COG0351	phosphomethylpyrimidine kinase
VV02_RS01170	COG0789	Transcriptional regulator
VV02_RS01175	COG4221	oxidoreductase activity
VV02_RS01180	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
VV02_RS01195	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
VV02_RS01200	COG0515	serine threonine protein kinase
VV02_RS01205	COG0596	Alpha beta hydrolase
VV02_RS01270	COG3360	Dodecin
VV02_RS01275	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
VV02_RS01285	COG1794	racemase activity, acting on amino acids and derivatives
VV02_RS01335	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VV02_RS01345	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VV02_RS01360	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
VV02_RS01430	COG1136	(ABC) transporter
VV02_RS01450	COG1136	(ABC) transporter
VV02_RS01500	COG2378	regulation of single-species biofilm formation
VV02_RS01505	COG0531	amino acid
VV02_RS01510	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
VV02_RS01530	COG1324	tolerance protein
VV02_RS01585	COG0640	Transcriptional regulator
VV02_RS01620	COG1201	RNA secondary structure unwinding
VV02_RS01675	COG1196	nuclear chromosome segregation
VV02_RS01675	COG0741	lytic transglycosylase activity
VV02_RS01675	COG0739	heme binding
VV02_RS01710	COG0604	alcohol dehydrogenase
VV02_RS01720	COG2149	membrane
VV02_RS01735	COG0668	transmembrane transport
VV02_RS01750	COG1902	pentaerythritol trinitrate reductase activity
VV02_RS01760	COG1595	DNA-templated transcription, initiation
VV02_RS01765	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
VV02_RS01780	COG0577	efflux transmembrane transporter activity
VV02_RS01780	COG1136	(ABC) transporter
VV02_RS01785	COG1136	(ABC) transporter
VV02_RS01800	COG0745	RESPONSE REGULATOR receiver
VV02_RS01805	COG2205	protein histidine kinase activity
VV02_RS01965	COG1716	ATPase activity
VV02_RS01980	COG0768	penicillin binding
VV02_RS01985	COG0515	serine threonine protein kinase
VV02_RS01990	COG0515	serine threonine protein kinase
VV02_RS02020	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
VV02_RS02045	COG3559	Exporter of polyketide antibiotics
VV02_RS02050	COG1131	(ABC) transporter
VV02_RS02070	COG1174	glycine betaine transport
VV02_RS02085	COG3795	YCII-related domain
VV02_RS02095	COG0477	Major facilitator Superfamily
VV02_RS02105	COG1181	Belongs to the D-alanine--D-alanine ligase family
VV02_RS02185	COG0515	serine threonine protein kinase
VV02_RS02195	COG1454	alcohol dehydrogenase
VV02_RS02200	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
VV02_RS02235	COG0477	Major facilitator Superfamily
VV02_RS02240	COG1309	transcriptional regulator
VV02_RS02245	COG0025	NhaP-type Na H and K H
VV02_RS02255	COG0667	Aldo Keto reductase
VV02_RS02280	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
VV02_RS02290	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
VV02_RS02295	COG0366	Alpha amylase catalytic
VV02_RS02295	COG1470	cell adhesion involved in biofilm formation
VV02_RS02305	COG1609	Transcriptional regulator
VV02_RS02315	COG1105	Belongs to the carbohydrate kinase PfkB family
VV02_RS02320	COG1940	carbohydrate kinase activity
VV02_RS02325	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
VV02_RS02330	COG1349	DNA-binding transcription factor activity
VV02_RS02340	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
VV02_RS02345	COG0187	DNA topoisomerase II activity
VV02_RS02355	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
VV02_RS02360	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
VV02_RS02365	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
VV02_RS02370	COG0592	DNA-directed DNA polymerase activity
VV02_RS02380	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
VV02_RS02385	COG0230	Belongs to the bacterial ribosomal protein bL34 family
VV02_RS02390	COG0594	ribonuclease P activity
VV02_RS02395	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
VV02_RS02400	COG0706	membrane insertase activity
VV02_RS02410	COG0357	Ribosomal RNA small subunit methyltransferase G
VV02_RS02415	COG1192	Involved in chromosome partitioning
VV02_RS02425	COG3118	belongs to the thioredoxin family
VV02_RS02430	COG0492	ferredoxin-NADP+ reductase activity
VV02_RS02440	COG1595	DNA-templated transcription, initiation
VV02_RS02525	COG2272	Belongs to the type-B carboxylesterase lipase family
VV02_RS02540	COG3629	intracellular signal transduction
VV02_RS02540	COG3903	Transcriptional regulator
VV02_RS02550	COG1260	myo-inositol-1-phosphate synthase
VV02_RS02560	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
VV02_RS02580	COG0360	Binds together with S18 to 16S ribosomal RNA
VV02_RS02590	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
VV02_RS02595	COG0359	binds to the 23S rRNA
VV02_RS02600	COG0534	Mate efflux family protein
VV02_RS02610	COG0791	NLP P60 protein
VV02_RS02615	COG0739	heme binding
VV02_RS02630	COG2197	response regulator
VV02_RS02635	COG4585	Histidine kinase
VV02_RS02645	COG0739	heme binding
VV02_RS02660	COG0477	Major facilitator Superfamily
VV02_RS02680	COG0745	RESPONSE REGULATOR receiver
VV02_RS02685	COG2205	protein histidine kinase activity
VV02_RS02690	COG0243	molybdopterin cofactor binding
VV02_RS02795	COG1196	nuclear chromosome segregation
VV02_RS02795	COG0741	lytic transglycosylase activity
VV02_RS02795	COG0739	heme binding
VV02_RS02865	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VV02_RS02875	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
VV02_RS02890	COG0439	Biotin carboxylase
VV02_RS02895	COG0640	Transcriptional regulator
VV02_RS02980	COG2318	DinB family
VV02_RS02985	COG0640	Transcriptional regulator
VV02_RS02995	COG2318	DinB family
VV02_RS03030	COG2814	Major facilitator Superfamily
VV02_RS03035	COG1595	DNA-templated transcription, initiation
VV02_RS03070	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
VV02_RS03075	COG0477	Major facilitator Superfamily
VV02_RS03085	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
VV02_RS03095	COG2188	Transcriptional regulator
VV02_RS03110	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
VV02_RS03130	COG0686	Belongs to the AlaDH PNT family
VV02_RS03140	COG4941	Belongs to the sigma-70 factor family
VV02_RS03145	COG3795	YCII-related domain
VV02_RS03155	COG2318	DinB family
VV02_RS03160	COG1309	transcriptional regulator
VV02_RS03165	COG0815	Transfers the fatty acyl group on membrane lipoproteins
VV02_RS03170	COG2133	pyrroloquinoline quinone binding
VV02_RS03250	COG0596	Alpha beta hydrolase
VV02_RS03250	COG0508	dehydrogenase complex catalyzes the overall conversion of
VV02_RS03310	COG0542	response to heat
VV02_RS03320	COG1733	regulation of RNA biosynthetic process
VV02_RS03395	COG0745	RESPONSE REGULATOR receiver
VV02_RS03435	COG3158	transport of potassium into the cell
VV02_RS03445	COG0583	DNA-binding transcription factor activity
VV02_RS03470	COG2409	Drug exporters of the RND superfamily
VV02_RS03495	COG2197	response regulator
VV02_RS03500	COG4585	Histidine kinase
VV02_RS03530	COG0477	Major facilitator Superfamily
VV02_RS03535	COG2337	Toxic component of a toxin-antitoxin (TA) module
VV02_RS03570	COG0667	Aldo Keto reductase
VV02_RS03590	COG1028	Short-chain dehydrogenase reductase Sdr
VV02_RS03595	COG2409	Drug exporters of the RND superfamily
VV02_RS03625	COG0778	Nitroreductase
VV02_RS03640	COG2826	transposase and inactivated derivatives, IS30 family
VV02_RS03660	COG0477	Major facilitator Superfamily
VV02_RS03670	COG0583	DNA-binding transcription factor activity
VV02_RS03680	COG0644	oxidoreductase
VV02_RS03720	COG0297	glycogen (starch) synthase activity
VV02_RS03725	COG2226	methyltransferase
VV02_RS03745	COG0456	acetyltransferase
VV02_RS03745	COG0454	-acetyltransferase
VV02_RS03780	COG2307	Protein conserved in bacteria
VV02_RS03780	COG2308	Evidence 4 Homologs of previously reported genes of
VV02_RS03810	COG1960	acyl-CoA dehydrogenase activity
VV02_RS03820	COG1804	L-carnitine dehydratase bile acid-inducible protein F
VV02_RS03835	COG2018	Roadblock/LC7 domain
VV02_RS03840	COG5002	protein histidine kinase activity
VV02_RS03850	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
VV02_RS03875	COG1024	Enoyl-CoA hydratase
VV02_RS03890	COG0697	spore germination
VV02_RS03905	COG0028	Belongs to the TPP enzyme family
VV02_RS03940	COG3511	phospholipase C
VV02_RS03955	COG1959	2 iron, 2 sulfur cluster binding
VV02_RS03975	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VV02_RS03980	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VV02_RS03985	COG1120	ATPase activity
VV02_RS04005	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
VV02_RS04020	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
VV02_RS04020	COG2755	lipolytic protein G-D-S-L family
VV02_RS04060	COG3629	intracellular signal transduction
VV02_RS04060	COG3903	Transcriptional regulator
VV02_RS04065	COG3629	intracellular signal transduction
VV02_RS04065	COG3903	Transcriptional regulator
VV02_RS04100	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
VV02_RS04105	COG2197	response regulator
VV02_RS04145	COG0640	Transcriptional regulator
VV02_RS04150	COG1012	belongs to the aldehyde dehydrogenase family
VV02_RS04165	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
VV02_RS04180	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
VV02_RS04180	COG1672	PFAM Archaeal ATPase
VV02_RS04190	COG4941	Belongs to the sigma-70 factor family
VV02_RS04235	COG0488	(ABC) transporter
VV02_RS04240	COG2124	cytochrome p450
VV02_RS04280	COG2826	transposase and inactivated derivatives, IS30 family
VV02_RS04285	COG1082	Xylose isomerase domain protein TIM barrel
VV02_RS04290	COG0673	inositol 2-dehydrogenase activity
VV02_RS04310	COG1172	Belongs to the binding-protein-dependent transport system permease family
VV02_RS04315	COG1129	ABC transporter
VV02_RS04350	COG2223	nitrite transmembrane transporter activity
VV02_RS04360	COG0318	PFAM AMP-dependent synthetase and ligase
VV02_RS04365	COG0477	Major facilitator Superfamily
VV02_RS04370	COG1522	sequence-specific DNA binding
VV02_RS04380	COG4607	ABC-type enterochelin transport system periplasmic component
VV02_RS04385	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VV02_RS04390	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VV02_RS04395	COG1120	ATPase activity
VV02_RS04400	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
VV02_RS04415	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
VV02_RS04420	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
VV02_RS04420	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
VV02_RS04435	COG4209	transmembrane transport
VV02_RS04440	COG0395	ABC-type sugar transport system, permease component
VV02_RS04470	COG1733	regulation of RNA biosynthetic process
VV02_RS04475	COG0702	epimerase
VV02_RS04520	COG2755	lipolytic protein G-D-S-L family
VV02_RS04555	COG1595	DNA-templated transcription, initiation
VV02_RS04565	COG0406	alpha-ribazole phosphatase activity
VV02_RS04580	COG1785	Belongs to the alkaline phosphatase family
VV02_RS04585	COG0477	Major facilitator Superfamily
VV02_RS04605	COG2814	Major facilitator Superfamily
VV02_RS04650	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
VV02_RS04655	COG2267	carboxylic ester hydrolase activity
VV02_RS04695	COG2226	methyltransferase
VV02_RS04700	COG0824	Thioesterase
VV02_RS04730	COG1136	(ABC) transporter
VV02_RS04730	COG0577	efflux transmembrane transporter activity
VV02_RS04740	COG0604	alcohol dehydrogenase
VV02_RS04750	COG0746	molybdenum cofactor guanylyltransferase activity
VV02_RS04770	COG2816	NAD+ diphosphatase activity
VV02_RS04775	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
VV02_RS04780	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
VV02_RS04785	COG1902	pentaerythritol trinitrate reductase activity
VV02_RS04795	COG0442	prolyl-tRNA aminoacylation
VV02_RS04810	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
VV02_RS04815	COG0402	S-adenosylhomocysteine deaminase activity
VV02_RS04820	COG1228	amidohydrolase
VV02_RS04830	COG2197	response regulator
VV02_RS04835	COG1595	DNA-templated transcription, initiation
VV02_RS04850	COG0508	dehydrogenase complex catalyzes the overall conversion of
VV02_RS04885	COG4143	(ABC) transporter
VV02_RS04890	COG1177	transmembrane transport
VV02_RS04895	COG3842	ATPase activity
VV02_RS04925	COG1309	transcriptional regulator
VV02_RS04950	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
VV02_RS04965	COG1131	(ABC) transporter
VV02_RS05025	COG0386	Belongs to the glutathione peroxidase family
VV02_RS05070	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
VV02_RS05100	COG0318	PFAM AMP-dependent synthetase and ligase
VV02_RS05115	COG0789	Transcriptional regulator
VV02_RS05115	COG4978	Transcriptional regulator
VV02_RS05130	COG2197	response regulator
VV02_RS05135	COG2205	protein histidine kinase activity
VV02_RS05140	COG0745	RESPONSE REGULATOR receiver
VV02_RS05155	COG2311	Membrane
VV02_RS05160	COG4585	Histidine kinase
VV02_RS05170	COG1940	carbohydrate kinase activity
VV02_RS05190	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
VV02_RS05200	COG0640	Transcriptional regulator
VV02_RS05205	COG1733	regulation of RNA biosynthetic process
VV02_RS05210	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VV02_RS05220	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
VV02_RS05250	COG0277	FAD linked oxidase domain protein
VV02_RS05265	COG2197	response regulator
VV02_RS05280	COG2755	lipolytic protein G-D-S-L family
VV02_RS05295	COG2755	lipolytic protein G-D-S-L family
VV02_RS05315	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
VV02_RS05330	COG1960	acyl-CoA dehydrogenase activity
VV02_RS05335	COG1024	Enoyl-CoA hydratase
VV02_RS05355	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
VV02_RS05365	COG0477	Major facilitator Superfamily
VV02_RS05400	COG0789	Transcriptional regulator
VV02_RS05410	COG1090	epimerase
VV02_RS05415	COG1309	transcriptional regulator
VV02_RS05435	COG1595	DNA-templated transcription, initiation
VV02_RS05440	COG2169	Transcriptional regulator
VV02_RS05440	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
VV02_RS05455	COG2226	methyltransferase
VV02_RS05475	COG0702	epimerase
VV02_RS05510	COG0277	FAD linked oxidase domain protein
VV02_RS05555	COG0438	transferase activity, transferring glycosyl groups
VV02_RS05570	COG0589	response to stress
VV02_RS05635	COG0443	Heat shock 70 kDa protein
VV02_RS05640	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
VV02_RS05645	COG0484	heat shock protein binding
VV02_RS05650	COG0789	Transcriptional regulator
VV02_RS05725	COG0477	Major facilitator Superfamily
VV02_RS05755	COG0439	Biotin carboxylase
VV02_RS05770	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
VV02_RS05795	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
VV02_RS05810	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
VV02_RS05815	COG3321	synthase
VV02_RS05815	COG0604	alcohol dehydrogenase
VV02_RS05830	COG0542	response to heat
VV02_RS05855	COG0477	Major facilitator Superfamily
VV02_RS05865	COG2072	flavoprotein involved in K transport
VV02_RS05885	COG4821	SIS domain
VV02_RS05890	COG1653	transport
VV02_RS05895	COG1175	transmembrane transport
VV02_RS05900	COG0395	ABC-type sugar transport system, permease component
VV02_RS05905	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
VV02_RS05910	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
VV02_RS05940	COG0318	PFAM AMP-dependent synthetase and ligase
VV02_RS05960	COG0708	Exodeoxyribonuclease III
VV02_RS05975	COG0300	oxidoreductase activity
VV02_RS05980	COG0673	inositol 2-dehydrogenase activity
VV02_RS05985	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
VV02_RS06020	COG2223	nitrite transmembrane transporter activity
VV02_RS06025	COG0243	molybdopterin cofactor binding
VV02_RS06030	COG2146	nitrite reductase [NAD(P)H] activity
VV02_RS06030	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
VV02_RS06035	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
VV02_RS06040	COG2146	nitrite reductase [NAD(P)H] activity
VV02_RS06045	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
VV02_RS06045	COG1648	precorrin-2 dehydrogenase activity
VV02_RS06060	COG1881	PFAM PEBP family protein
VV02_RS06070	COG1704	LemA family
VV02_RS06075	COG1388	LysM domain
VV02_RS06085	COG2197	response regulator
VV02_RS06130	COG2318	DinB family
VV02_RS06155	COG4941	Belongs to the sigma-70 factor family
VV02_RS06180	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
VV02_RS06205	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
VV02_RS06210	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
VV02_RS06250	COG0287	Prephenate dehydrogenase
VV02_RS06250	COG1605	Chorismate mutase
VV02_RS06255	COG3973	AAA domain
VV02_RS06270	COG0151	Belongs to the GarS family
VV02_RS06280	COG1486	melibiose metabolic process
VV02_RS06290	COG4585	Histidine kinase
VV02_RS06295	COG2197	response regulator
VV02_RS06300	COG2409	Drug exporters of the RND superfamily
VV02_RS06310	COG0047	phosphoribosylformylglycinamidine synthase activity
VV02_RS06310	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
VV02_RS06315	COG2072	flavoprotein involved in K transport
VV02_RS06320	COG2197	response regulator
VV02_RS06330	COG3467	pyridoxamine 5'-phosphate
VV02_RS06335	COG0477	Major facilitator Superfamily
VV02_RS06385	COG1266	CAAX protease self-immunity
VV02_RS06400	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
VV02_RS06425	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
VV02_RS06480	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
VV02_RS06510	COG2274	protein secretion by the type I secretion system
VV02_RS06520	COG2124	cytochrome p450
VV02_RS06550	COG1739	Uncharacterized protein family UPF0029
VV02_RS06570	COG0254	rRNA binding
VV02_RS06575	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
VV02_RS06580	COG0267	Belongs to the bacterial ribosomal protein bL33 family
VV02_RS06600	COG2365	Tyrosine phosphatase family
VV02_RS06630	COG1796	DNA polymerase
VV02_RS06630	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
VV02_RS06635	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
VV02_RS06675	COG1309	transcriptional regulator
VV02_RS06700	COG3629	intracellular signal transduction
VV02_RS06700	COG3903	Transcriptional regulator
VV02_RS06735	COG2197	response regulator
VV02_RS06740	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VV02_RS06745	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
VV02_RS06750	COG1929	Belongs to the glycerate kinase type-1 family
VV02_RS06770	COG0673	inositol 2-dehydrogenase activity
VV02_RS06775	COG1609	Transcriptional regulator
VV02_RS06780	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
VV02_RS06785	COG1609	Transcriptional regulator
VV02_RS06800	COG4209	transmembrane transport
VV02_RS06805	COG0395	ABC-type sugar transport system, permease component
VV02_RS06845	COG1556	Lactate utilization protein
VV02_RS06850	COG1139	Iron-sulfur cluster binding protein
VV02_RS06855	COG0247	lactate metabolic process
VV02_RS06870	COG1172	Belongs to the binding-protein-dependent transport system permease family
VV02_RS06875	COG1129	ABC transporter
VV02_RS06880	COG4948	Mandelate Racemase Muconate Lactonizing
VV02_RS06885	COG0179	Fumarylacetoacetate (FAA) hydrolase
VV02_RS06910	COG1595	DNA-templated transcription, initiation
VV02_RS06925	COG4166	transmembrane transport
VV02_RS06935	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VV02_RS06940	COG1609	Transcriptional regulator
VV02_RS06945	COG1879	ABC-type sugar transport system periplasmic component
VV02_RS06950	COG1129	ABC transporter
VV02_RS06955	COG1172	Belongs to the binding-protein-dependent transport system permease family
VV02_RS06960	COG1172	Belongs to the binding-protein-dependent transport system permease family
VV02_RS06995	COG0438	transferase activity, transferring glycosyl groups
VV02_RS07000	COG0667	Aldo Keto reductase
VV02_RS07080	COG0581	inorganic phosphate transmembrane transporter activity
VV02_RS07100	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
VV02_RS07105	COG0456	acetyltransferase
VV02_RS07110	COG1525	nuclease
VV02_RS07110	COG0737	Belongs to the 5'-nucleotidase family
VV02_RS07110	COG4085	toxin activity
VV02_RS07120	COG0745	RESPONSE REGULATOR receiver
VV02_RS07135	COG4044	May play a role in the intracellular transport of hydrophobic ligands
VV02_RS07140	COG1316	TRANSCRIPTIONal
VV02_RS07145	COG0354	folic acid binding
VV02_RS07160	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
VV02_RS07175	COG1490	D-aminoacyl-tRNA deacylase activity
VV02_RS07215	COG0297	glycogen (starch) synthase activity
VV02_RS07225	COG0588	phosphoglycerate mutase activity
VV02_RS07235	COG5002	protein histidine kinase activity
VV02_RS07250	COG1329	Transcriptional regulator
VV02_RS07255	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
VV02_RS07260	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
VV02_RS07275	COG0583	DNA-binding transcription factor activity
VV02_RS07285	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VV02_RS07300	COG0706	membrane insertase activity
VV02_RS07310	COG0215	cysteine-tRNA ligase activity
VV02_RS07335	COG3842	ATPase activity
VV02_RS07345	COG1175	transmembrane transport
VV02_RS07350	COG3833	ABC-type maltose transport systems, permease component
VV02_RS07365	COG0405	Gamma-glutamyltransferase
VV02_RS07370	COG0583	DNA-binding transcription factor activity
VV02_RS07385	COG1877	trehalose-phosphatase activity
VV02_RS07385	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
VV02_RS07390	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
VV02_RS07405	COG2966	Psort location CytoplasmicMembrane, score
VV02_RS07410	COG1652	LysM domain
VV02_RS07800	COG4257	antibiotic catabolic process
VV02_RS07815	COG1960	acyl-CoA dehydrogenase activity
VV02_RS07830	COG2318	DinB family
VV02_RS07865	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
VV02_RS07900	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
VV02_RS07905	COG0076	glutamate decarboxylase activity
VV02_RS07920	COG1733	regulation of RNA biosynthetic process
VV02_RS07925	COG0477	Major facilitator Superfamily
VV02_RS07945	COG0459	protein refolding
VV02_RS07950	COG3158	transport of potassium into the cell
VV02_RS07960	COG1028	Short-chain dehydrogenase reductase Sdr
VV02_RS07990	COG2154	pterin-4-alpha-carbinolamine dehydratase
VV02_RS08000	COG0446	pyridine nucleotide-disulphide oxidoreductase
VV02_RS08000	COG1902	pentaerythritol trinitrate reductase activity
VV02_RS08010	COG0657	acetylesterase activity
VV02_RS08015	COG1136	(ABC) transporter
VV02_RS08020	COG1136	(ABC) transporter
VV02_RS08020	COG0577	efflux transmembrane transporter activity
VV02_RS08035	COG3973	AAA domain
VV02_RS08045	COG2409	Drug exporters of the RND superfamily
VV02_RS08055	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
VV02_RS08060	COG2205	protein histidine kinase activity
VV02_RS08065	COG0745	RESPONSE REGULATOR receiver
VV02_RS08070	COG1846	Transcriptional regulator
VV02_RS08075	COG2814	Major facilitator Superfamily
VV02_RS08095	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
VV02_RS08110	COG0259	pyridoxamine-phosphate oxidase activity
VV02_RS08135	COG1253	flavin adenine dinucleotide binding
VV02_RS08140	COG1253	flavin adenine dinucleotide binding
VV02_RS08145	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
VV02_RS08150	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
VV02_RS08180	COG0860	N-Acetylmuramoyl-L-alanine amidase
VV02_RS08185	COG2409	Drug exporters of the RND superfamily
VV02_RS08195	COG4221	oxidoreductase activity
VV02_RS08200	COG0492	ferredoxin-NADP+ reductase activity
VV02_RS08210	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
VV02_RS08245	COG2197	response regulator
VV02_RS08250	COG4585	Histidine kinase
VV02_RS08270	COG1609	Transcriptional regulator
VV02_RS08310	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
VV02_RS08310	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
VV02_RS08320	COG1970	mechanosensitive ion channel activity
VV02_RS08330	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
VV02_RS08340	COG3263	regulation of cellular component size
VV02_RS08355	COG1210	Utp--glucose-1-phosphate uridylyltransferase
VV02_RS08365	COG0315	cyclic pyranopterin monophosphate synthase activity
VV02_RS08370	COG0521	Mo-molybdopterin cofactor biosynthetic process
VV02_RS08370	COG0315	cyclic pyranopterin monophosphate synthase activity
VV02_RS08375	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VV02_RS08385	COG0306	phosphate transporter
VV02_RS08405	COG0667	Aldo Keto reductase
VV02_RS08425	COG3833	ABC-type maltose transport systems, permease component
VV02_RS08435	COG3842	ATPase activity
VV02_RS08440	COG1132	(ABC) transporter
VV02_RS08485	COG3511	phospholipase C
VV02_RS08560	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VV02_RS08565	COG0084	hydrolase, TatD family'
VV02_RS08570	COG3583	domain protein
VV02_RS08585	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
VV02_RS08590	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
VV02_RS08595	COG0488	(ABC) transporter
VV02_RS08610	COG4106	trans-aconitate 2-methyltransferase activity
VV02_RS08630	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
VV02_RS08635	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
VV02_RS08640	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
VV02_RS08650	COG0193	aminoacyl-tRNA hydrolase activity
VV02_RS08665	COG1216	Glycosyl transferase, family 2
VV02_RS08680	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
VV02_RS08745	COG2244	polysaccharide biosynthetic process
VV02_RS08750	COG0463	Glycosyl transferase, family 2
VV02_RS08750	COG1216	Glycosyl transferase, family 2
VV02_RS08770	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
VV02_RS08805	COG0148	phosphopyruvate hydratase activity
VV02_RS08825	COG0395	ABC-type sugar transport system, permease component
VV02_RS08830	COG4209	transmembrane transport
VV02_RS08835	COG1653	transport
VV02_RS08840	COG0366	Alpha amylase catalytic
VV02_RS08845	COG1609	Transcriptional regulator
VV02_RS08875	COG2197	response regulator
VV02_RS08880	COG4585	Histidine kinase
VV02_RS08890	COG1131	(ABC) transporter
VV02_RS08920	COG0183	Belongs to the thiolase family
VV02_RS08925	COG2755	lipolytic protein G-D-S-L family
VV02_RS08950	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
VV02_RS08950	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
VV02_RS08955	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
VV02_RS08965	COG1528	Iron-storage protein
VV02_RS08990	COG0740	serine-type endopeptidase activity
VV02_RS08995	COG0740	serine-type endopeptidase activity
VV02_RS09010	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VV02_RS09035	COG0752	glycyl-tRNA synthetase alpha subunit
VV02_RS09035	COG0751	glycine-tRNA ligase activity
VV02_RS09075	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
VV02_RS09085	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
VV02_RS09100	COG1126	abc transporter atp-binding protein
VV02_RS09105	COG0765	amino acid transport
VV02_RS09110	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VV02_RS09120	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
VV02_RS09145	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
VV02_RS09175	COG0765	amino acid transport
VV02_RS09180	COG0765	amino acid transport
VV02_RS09185	COG1126	abc transporter atp-binding protein
VV02_RS09190	COG3833	ABC-type maltose transport systems, permease component
VV02_RS09195	COG1175	transmembrane transport
VV02_RS09210	COG0477	Major facilitator Superfamily
VV02_RS09220	COG1309	transcriptional regulator
VV02_RS09235	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
VV02_RS09245	COG0114	fumarate hydratase activity
VV02_RS09255	COG1072	(Pantothenic acid kinase))
VV02_RS09265	COG0736	holo-[acyl-carrier-protein] synthase activity
VV02_RS09280	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
VV02_RS09290	COG0802	atpase or kinase
VV02_RS09305	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
VV02_RS09310	COG1472	Belongs to the glycosyl hydrolase 3 family
VV02_RS09315	COG0477	Major facilitator Superfamily
VV02_RS09330	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
VV02_RS09335	COG1764	response to oxidative stress
VV02_RS09345	COG0569	domain protein
VV02_RS09350	COG0596	Alpha beta hydrolase
VV02_RS09355	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
VV02_RS09375	COG0604	alcohol dehydrogenase
VV02_RS09380	COG1733	regulation of RNA biosynthetic process
VV02_RS09385	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
VV02_RS09390	COG0459	protein refolding
VV02_RS09405	COG1595	DNA-templated transcription, initiation
VV02_RS09430	COG1917	Cupin 2, conserved barrel domain protein
VV02_RS09430	COG4977	sequence-specific DNA binding
VV02_RS09450	COG0587	DNA-directed DNA polymerase activity
VV02_RS09470	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VV02_RS09495	COG0516	GMP reductase activity
VV02_RS09505	COG1012	belongs to the aldehyde dehydrogenase family
VV02_RS09515	COG1132	(ABC) transporter
VV02_RS09535	COG0519	Catalyzes the synthesis of GMP from XMP
VV02_RS09535	COG0518	GMP synthase (glutamine-hydrolyzing) activity
VV02_RS09550	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
VV02_RS09560	COG1051	belongs to the nudix hydrolase family
VV02_RS09580	COG2197	response regulator
VV02_RS09595	COG1012	belongs to the aldehyde dehydrogenase family
VV02_RS09615	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
VV02_RS09680	COG0739	heme binding
VV02_RS09685	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
VV02_RS09695	COG0045	succinate-CoA ligase (ADP-forming) activity
VV02_RS09720	COG0138	bifunctional purine biosynthesis protein purh
VV02_RS09740	COG0454	-acetyltransferase
VV02_RS09740	COG0456	acetyltransferase
VV02_RS09755	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
VV02_RS09765	COG0039	L-malate dehydrogenase activity
VV02_RS09805	COG0489	protein tyrosine kinase activity
VV02_RS09820	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
VV02_RS09825	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
VV02_RS09875	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
VV02_RS09880	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
VV02_RS09885	COG1086	Polysaccharide biosynthesis protein
VV02_RS09895	COG0708	Exodeoxyribonuclease III
VV02_RS09905	COG1506	peptidase
VV02_RS09905	COG4946	Tricorn protease homolog
VV02_RS09905	COG0823	Involved in the tonB-independent uptake of proteins
VV02_RS09915	COG1349	DNA-binding transcription factor activity
VV02_RS09920	COG0180	Tryptophanyl-tRNA synthetase
VV02_RS09935	COG1053	succinate dehydrogenase
VV02_RS09950	COG1053	succinate dehydrogenase
VV02_RS09960	COG0438	transferase activity, transferring glycosyl groups
VV02_RS09965	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
VV02_RS09965	COG0662	Cupin 2, conserved barrel domain protein
VV02_RS09970	COG0167	dihydroorotate dehydrogenase activity
VV02_RS09985	COG1473	amidohydrolase
VV02_RS09985	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
VV02_RS09990	COG1744	ABC transporter substrate-binding protein PnrA-like
VV02_RS09995	COG3845	ABC transporter
VV02_RS10000	COG4603	Belongs to the binding-protein-dependent transport system permease family
VV02_RS10005	COG1079	Belongs to the binding-protein-dependent transport system permease family
VV02_RS10045	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
VV02_RS10065	COG0714	Associated with various cellular activities
VV02_RS10095	COG1012	belongs to the aldehyde dehydrogenase family
VV02_RS10100	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
VV02_RS10120	COG2188	Transcriptional regulator
VV02_RS10125	COG0673	inositol 2-dehydrogenase activity
VV02_RS10130	COG1082	Xylose isomerase domain protein TIM barrel
VV02_RS10145	COG3718	enzyme involved in inositol metabolism
VV02_RS10150	COG3962	Belongs to the TPP enzyme family
VV02_RS10160	COG1172	Belongs to the binding-protein-dependent transport system permease family
VV02_RS10190	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
VV02_RS10230	COG4770	biotin carboxylase activity
VV02_RS10235	COG0656	L-ascorbic acid biosynthetic process
VV02_RS10260	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
VV02_RS10275	COG1960	acyl-CoA dehydrogenase activity
VV02_RS10280	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
VV02_RS10285	COG2814	Major facilitator Superfamily
VV02_RS10290	COG0424	maF-like protein
VV02_RS10295	COG1185	polyribonucleotide nucleotidyltransferase activity
VV02_RS10335	COG2258	MOSC domain
VV02_RS10340	COG0730	response to heat
VV02_RS10350	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
VV02_RS10365	COG1024	Enoyl-CoA hydratase
VV02_RS10370	COG0745	RESPONSE REGULATOR receiver
VV02_RS10390	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
VV02_RS10395	COG0583	DNA-binding transcription factor activity
VV02_RS10430	COG1316	TRANSCRIPTIONal
VV02_RS10465	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
VV02_RS10480	COG1086	Polysaccharide biosynthesis protein
VV02_RS10485	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
VV02_RS10515	COG1216	Glycosyl transferase, family 2
VV02_RS10520	COG2089	acid synthase
VV02_RS10535	COG0318	PFAM AMP-dependent synthetase and ligase
VV02_RS10540	COG1028	Short-chain dehydrogenase reductase Sdr
VV02_RS10590	COG1028	Short-chain dehydrogenase reductase Sdr
VV02_RS10610	COG0745	RESPONSE REGULATOR receiver
VV02_RS10615	COG2205	protein histidine kinase activity
VV02_RS10620	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
VV02_RS10620	COG0778	Nitroreductase
VV02_RS10625	COG0391	Required for morphogenesis under gluconeogenic growth conditions
VV02_RS10660	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
VV02_RS10665	COG2835	tetraacyldisaccharide 4'-kinase activity
VV02_RS10675	COG3483	tryptophan 2,3-dioxygenase activity
VV02_RS10685	COG2354	Protein conserved in bacteria
VV02_RS10695	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
VV02_RS10700	COG0745	RESPONSE REGULATOR receiver
VV02_RS10705	COG5002	protein histidine kinase activity
VV02_RS10720	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
VV02_RS10725	COG2197	response regulator
VV02_RS10735	COG1595	DNA-templated transcription, initiation
VV02_RS10745	COG0653	protein targeting
VV02_RS10775	COG0489	protein tyrosine kinase activity
VV02_RS10800	COG1012	belongs to the aldehyde dehydrogenase family
VV02_RS10815	COG2902	Dehydrogenase
VV02_RS10900	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
VV02_RS10905	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
VV02_RS10905	COG2226	methyltransferase
VV02_RS10905	COG0596	Alpha beta hydrolase
VV02_RS10910	COG2197	response regulator
VV02_RS10915	COG4585	Histidine kinase
VV02_RS10920	COG0277	FAD linked oxidase domain protein
VV02_RS10935	COG2884	Cell division ATP-binding protein ftsE
VV02_RS10940	COG2177	Part of the ABC transporter FtsEX involved in
VV02_RS10945	COG1196	nuclear chromosome segregation
VV02_RS10945	COG0741	lytic transglycosylase activity
VV02_RS10945	COG0739	heme binding
VV02_RS10950	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
VV02_RS10975	COG3938	Belongs to the proline racemase family
VV02_RS10995	COG2022	thiamine diphosphate biosynthetic process
VV02_RS10995	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VV02_RS11005	COG0006	proline dipeptidase activity
VV02_RS11015	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
VV02_RS11040	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
VV02_RS11065	COG0513	Belongs to the DEAD box helicase family
VV02_RS11070	COG1678	Uncharacterized ACR, COG1678
VV02_RS11170	COG3185	4-Hydroxyphenylpyruvate dioxygenase
VV02_RS11175	COG0477	Major facilitator Superfamily
VV02_RS11180	COG1733	regulation of RNA biosynthetic process
VV02_RS11185	COG1028	Short-chain dehydrogenase reductase Sdr
VV02_RS11190	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
VV02_RS11210	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
VV02_RS11215	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VV02_RS11220	COG0006	proline dipeptidase activity
VV02_RS11235	COG0154	amidase activity
VV02_RS11285	COG2326	polyphosphate kinase activity
VV02_RS11295	COG1309	transcriptional regulator
VV02_RS11300	COG0179	Fumarylacetoacetate (FAA) hydrolase
VV02_RS11315	COG0737	Belongs to the 5'-nucleotidase family
VV02_RS11320	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VV02_RS11325	COG1335	isochorismatase
VV02_RS11330	COG4585	Histidine kinase
VV02_RS11335	COG2197	response regulator
VV02_RS11340	COG1131	(ABC) transporter
VV02_RS11365	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
VV02_RS11380	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
VV02_RS11425	COG1414	Transcriptional regulator
VV02_RS11440	COG0776	regulation of translation
VV02_RS11460	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
VV02_RS11470	COG1181	Belongs to the D-alanine--D-alanine ligase family
VV02_RS11500	COG5640	endopeptidase activity
VV02_RS11510	COG5640	endopeptidase activity
VV02_RS11515	COG2226	methyltransferase
VV02_RS11520	COG0227	Belongs to the bacterial ribosomal protein bL28 family
VV02_RS11525	COG1461	Dihydroxyacetone kinase
VV02_RS11535	COG0742	ribosomal rna small subunit methyltransferase
VV02_RS11545	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
VV02_RS11560	COG0333	Belongs to the bacterial ribosomal protein bL32 family
VV02_RS11565	COG0571	ribonuclease III activity
VV02_RS11570	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
VV02_RS11575	COG0339	signal peptide processing
VV02_RS11580	COG2132	Multicopper oxidase
VV02_RS11650	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
VV02_RS11690	COG1609	Transcriptional regulator
VV02_RS11720	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
VV02_RS11745	COG1309	transcriptional regulator
VV02_RS11755	COG0228	four-way junction DNA binding
VV02_RS11760	COG1837	Belongs to the UPF0109 family
VV02_RS11770	COG2197	response regulator
VV02_RS11780	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
VV02_RS11785	COG0336	Belongs to the RNA methyltransferase TrmD family
VV02_RS11795	COG0681	Belongs to the peptidase S26 family
VV02_RS11800	COG0681	Belongs to the peptidase S26 family
VV02_RS11810	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
VV02_RS11820	COG0792	nuclease activity
VV02_RS11830	COG0758	DNA mediated transformation
VV02_RS11835	COG4974	Belongs to the 'phage' integrase family
VV02_RS11875	COG0052	Belongs to the universal ribosomal protein uS2 family
VV02_RS11880	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
VV02_RS11895	COG0528	UMP kinase activity
VV02_RS11900	COG0233	cytoplasmic translational termination
VV02_RS11910	COG0820	rRNA (adenine-C2-)-methyltransferase activity
VV02_RS11915	COG1280	lysine exporter protein (LysE YggA)
VV02_RS11935	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
VV02_RS11970	COG3268	Saccharopine dehydrogenase
VV02_RS12005	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
VV02_RS12015	COG1760	l-serine dehydratase
VV02_RS12020	COG1012	belongs to the aldehyde dehydrogenase family
VV02_RS12040	COG3511	phospholipase C
VV02_RS12050	COG2822	iron ion transport
VV02_RS12075	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
VV02_RS12080	COG0750	zinc metalloprotease
VV02_RS12085	COG1619	proteins homologs of microcin C7 resistance protein MccF
VV02_RS12090	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
VV02_RS12120	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
VV02_RS12145	COG0442	prolyl-tRNA aminoacylation
VV02_RS12155	COG0483	inositol monophosphate 1-phosphatase activity
VV02_RS12175	COG1028	Short-chain dehydrogenase reductase Sdr
VV02_RS12185	COG2843	Capsule synthesis protein
VV02_RS12195	COG1331	Highly conserved protein containing a thioredoxin domain
VV02_RS12225	COG1175	transmembrane transport
VV02_RS12230	COG0395	ABC-type sugar transport system, permease component
VV02_RS12245	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VV02_RS12250	COG0537	adenosine 5'-monophosphoramidase activity
VV02_RS12270	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
VV02_RS12275	COG0175	sulfate reduction
VV02_RS12280	COG0529	Catalyzes the synthesis of activated sulfate
VV02_RS12295	COG0779	Required for maturation of 30S ribosomal subunits
VV02_RS12310	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
VV02_RS12315	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
VV02_RS12325	COG1262	PFAM Formylglycine-generating sulfatase enzyme
VV02_RS12335	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
VV02_RS12345	COG0477	Major facilitator Superfamily
VV02_RS12350	COG1309	transcriptional regulator
VV02_RS12360	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
VV02_RS12365	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
VV02_RS12380	COG1280	lysine exporter protein (LysE YggA)
VV02_RS12405	COG1136	(ABC) transporter
VV02_RS12425	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
VV02_RS12440	COG1530	ribonuclease E activity
VV02_RS12445	COG0261	This protein binds to 23S rRNA in the presence of protein L20
VV02_RS12450	COG0211	Belongs to the bacterial ribosomal protein bL27 family
VV02_RS12455	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
VV02_RS12460	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
VV02_RS12470	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
VV02_RS12475	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
VV02_RS12480	COG0463	Glycosyl transferase, family 2
VV02_RS12490	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
VV02_RS12495	COG0799	negative regulation of ribosome biogenesis
VV02_RS12500	COG0406	alpha-ribazole phosphatase activity
VV02_RS12540	COG0640	Transcriptional regulator
VV02_RS12545	COG1609	Transcriptional regulator
VV02_RS12555	COG1175	transmembrane transport
VV02_RS12570	COG1175	transmembrane transport
VV02_RS12575	COG0395	ABC-type sugar transport system, permease component
VV02_RS12595	COG1070	Carbohydrate kinase
VV02_RS12640	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VV02_RS12650	COG1472	Belongs to the glycosyl hydrolase 3 family
VV02_RS12655	COG0395	ABC-type sugar transport system, permease component
VV02_RS12660	COG1175	transmembrane transport
VV02_RS12670	COG1960	acyl-CoA dehydrogenase activity
VV02_RS12690	COG0247	lactate metabolic process
VV02_RS12695	COG0277	FAD linked oxidase domain protein
VV02_RS12700	COG0277	FAD linked oxidase domain protein
VV02_RS12705	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
VV02_RS12715	COG0659	secondary active sulfate transmembrane transporter activity
VV02_RS12720	COG2814	Major facilitator Superfamily
VV02_RS12725	COG0481	GTPase activity
VV02_RS12730	COG0220	tRNA (guanine-N7-)-methyltransferase activity
VV02_RS12750	COG2119	membrane
VV02_RS12760	COG0583	DNA-binding transcription factor activity
VV02_RS12765	COG2855	membrane
VV02_RS12805	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
VV02_RS12825	COG1420	regulation of RNA biosynthetic process
VV02_RS12830	COG0484	heat shock protein binding
VV02_RS12840	COG0640	Transcriptional regulator
VV02_RS12845	COG0477	Major facilitator Superfamily
VV02_RS12855	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
VV02_RS12865	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
VV02_RS12870	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
VV02_RS12885	COG2837	iron assimilation
VV02_RS12915	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
VV02_RS12965	COG1381	Involved in DNA repair and RecF pathway recombination
VV02_RS12970	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
VV02_RS12980	COG1108	ABC-type Mn2 Zn2 transport systems permease components
VV02_RS12990	COG0803	Belongs to the bacterial solute-binding protein 9 family
VV02_RS13005	COG1131	(ABC) transporter
VV02_RS13010	COG0842	Transport permease protein
VV02_RS13015	COG4585	Histidine kinase
VV02_RS13020	COG2197	response regulator
VV02_RS13055	COG0232	Belongs to the dGTPase family. Type 2 subfamily
VV02_RS13065	COG0358	DNA primase activity
VV02_RS13165	COG0765	amino acid transport
VV02_RS13170	COG0765	amino acid transport
VV02_RS13175	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VV02_RS13180	COG1126	abc transporter atp-binding protein
VV02_RS13195	COG0515	serine threonine protein kinase
VV02_RS13215	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
VV02_RS13220	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
VV02_RS13255	COG0584	glycerophosphoryl diester phosphodiesterase
VV02_RS13260	COG2226	methyltransferase
VV02_RS13265	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
VV02_RS13285	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
VV02_RS13310	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
VV02_RS13315	COG3022	response to hydroperoxide
VV02_RS13330	COG4585	Histidine kinase
VV02_RS13335	COG2197	response regulator
VV02_RS13340	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
VV02_RS13355	COG1396	sequence-specific DNA binding
VV02_RS13415	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
VV02_RS13420	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
VV02_RS13425	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
VV02_RS13430	COG0131	Imidazoleglycerol-phosphate dehydratase
VV02_RS13440	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
VV02_RS13445	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
VV02_RS13460	COG0492	ferredoxin-NADP+ reductase activity
VV02_RS13490	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
VV02_RS13510	COG0395	ABC-type sugar transport system, permease component
VV02_RS13520	COG1063	alcohol dehydrogenase
VV02_RS13525	COG1063	alcohol dehydrogenase
VV02_RS13530	COG1070	Carbohydrate kinase
VV02_RS13550	COG1733	regulation of RNA biosynthetic process
VV02_RS13555	COG2910	NAD(P)H-binding
VV02_RS13575	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
VV02_RS13580	COG0291	Belongs to the bacterial ribosomal protein bL35 family
VV02_RS13585	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
VV02_RS13590	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
VV02_RS13595	COG5002	protein histidine kinase activity
VV02_RS13600	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
VV02_RS13605	COG0072	phenylalanine-tRNA ligase activity
VV02_RS13605	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VV02_RS13610	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
VV02_RS13615	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
VV02_RS13620	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
VV02_RS13625	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
VV02_RS13630	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
VV02_RS13635	COG1438	arginine binding
VV02_RS13640	COG0165	Argininosuccinate lyase
VV02_RS13645	COG2094	Belongs to the DNA glycosylase MPG family
VV02_RS13650	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
VV02_RS13680	COG0647	UMP catabolic process
VV02_RS13700	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
VV02_RS13705	COG0497	DNA recombination
VV02_RS13730	COG0297	glycogen (starch) synthase activity
VV02_RS13735	COG0504	CTP synthase activity
VV02_RS13740	COG0494	nUDIX hydrolase
VV02_RS13745	COG0137	argininosuccinate synthase activity
VV02_RS13760	COG3012	SEC-C Motif Domain Protein
VV02_RS13765	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
VV02_RS13780	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
VV02_RS13800	COG0747	negative chemotaxis
VV02_RS13805	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VV02_RS13810	COG4166	transmembrane transport
VV02_RS13820	COG0444	Belongs to the ABC transporter superfamily
VV02_RS13825	COG4608	Belongs to the ABC transporter superfamily
VV02_RS13830	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
VV02_RS13835	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
VV02_RS13845	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
VV02_RS13850	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
VV02_RS13855	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
VV02_RS13860	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
VV02_RS13865	COG0069	glutamate synthase activity
VV02_RS13875	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
VV02_RS13880	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
VV02_RS13890	COG4691	Plasmid stability protein
VV02_RS13900	COG1051	belongs to the nudix hydrolase family
VV02_RS13905	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
VV02_RS13910	COG0540	Belongs to the ATCase OTCase family
VV02_RS13915	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
VV02_RS13920	COG0505	Belongs to the CarA family
VV02_RS13925	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
VV02_RS13930	COG0284	orotidine-5'-phosphate decarboxylase activity
VV02_RS13940	COG0667	Aldo Keto reductase
VV02_RS13955	COG0194	GDP metabolic process
VV02_RS13960	COG1758	RNA polymerase activity
VV02_RS13970	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
VV02_RS13990	COG0242	peptide deformylase activity
VV02_RS13995	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
VV02_RS14005	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
VV02_RS14020	COG3201	nicotinamide mononucleotide transporter
VV02_RS14025	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
VV02_RS14025	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
VV02_RS14030	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
VV02_RS14035	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
VV02_RS14040	COG0140	phosphoribosyl-ATP diphosphatase activity
VV02_RS14045	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
VV02_RS14055	COG4129	membrane
VV02_RS14065	COG0572	uridine kinase
VV02_RS14070	COG0107	imidazoleglycerol-phosphate synthase activity
VV02_RS14085	COG1132	(ABC) transporter
VV02_RS14095	COG3655	Transcriptional regulator
VV02_RS14105	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
VV02_RS14125	COG0134	indole-3-glycerol-phosphate synthase activity
VV02_RS14130	COG0133	tryptophan synthase activity
VV02_RS14155	COG0069	glutamate synthase activity
VV02_RS14155	COG0070	glutamate synthase
VV02_RS14155	COG0067	glutamate synthase
VV02_RS14165	COG0469	pyruvate kinase activity
VV02_RS14225	COG2050	protein possibly involved in aromatic compounds catabolism
VV02_RS14250	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
VV02_RS14250	COG2755	lipolytic protein G-D-S-L family
VV02_RS14260	COG2755	lipolytic protein G-D-S-L family
VV02_RS14260	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
VV02_RS14285	COG0463	Glycosyl transferase, family 2
VV02_RS14290	COG0438	transferase activity, transferring glycosyl groups
VV02_RS14310	COG0500	methyltransferase
VV02_RS14315	COG4981	capsule polysaccharide biosynthetic process
VV02_RS14335	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
VV02_RS14340	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
VV02_RS14360	COG2226	methyltransferase
VV02_RS14365	COG0539	negative regulation of cytoplasmic translation
VV02_RS14375	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
VV02_RS14375	COG0237	dephospho-CoA kinase activity
VV02_RS14385	COG0095	Lipoate-protein ligase
VV02_RS14390	COG0556	nucleotide-excision repair
VV02_RS14410	COG5006	permease, DMT superfamily
VV02_RS14415	COG0791	NLP P60 protein
VV02_RS14430	COG3387	PFAM Glycoside hydrolase 15-related
VV02_RS14435	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
VV02_RS14440	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VV02_RS14440	COG0723	plastoquinol--plastocyanin reductase activity
VV02_RS14445	COG0322	excinuclease ABC activity
VV02_RS14450	COG1660	Displays ATPase and GTPase activities
VV02_RS14460	COG1481	regulation of sporulation
VV02_RS14465	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
VV02_RS14470	COG0126	phosphoglycerate kinase activity
VV02_RS14475	COG0149	triose-phosphate isomerase activity
VV02_RS14480	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
VV02_RS14490	COG0363	glucosamine-6-phosphate deaminase activity
VV02_RS14505	COG0166	Belongs to the GPI family
VV02_RS14510	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
VV02_RS14520	COG0109	protoheme IX farnesyltransferase activity
VV02_RS14545	COG1472	Belongs to the glycosyl hydrolase 3 family
VV02_RS14570	COG0396	ATPase activity
VV02_RS14580	COG0822	iron-sulfur transferase activity
VV02_RS14585	COG2151	metal-sulfur cluster biosynthetic enzyme
VV02_RS14590	COG2409	Drug exporters of the RND superfamily
VV02_RS14605	COG0488	(ABC) transporter
VV02_RS14615	COG1024	Enoyl-CoA hydratase
VV02_RS14620	COG1132	(ABC) transporter
VV02_RS14635	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
VV02_RS14645	COG3214	Protein conserved in bacteria
VV02_RS14665	COG1028	Short-chain dehydrogenase reductase Sdr
VV02_RS14670	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
VV02_RS14675	COG0189	ligase activity
VV02_RS14675	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
VV02_RS14685	COG1181	Belongs to the D-alanine--D-alanine ligase family
VV02_RS14685	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
VV02_RS14695	COG0560	Phosphoserine phosphatase
VV02_RS14695	COG3830	Belongs to the UPF0237 family
VV02_RS14700	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
VV02_RS14705	COG0297	glycogen (starch) synthase activity
VV02_RS14710	COG1595	DNA-templated transcription, initiation
VV02_RS14725	COG1119	ATPase activity
VV02_RS14730	COG0456	acetyltransferase
VV02_RS14745	COG0515	serine threonine protein kinase
VV02_RS14745	COG2815	serine threonine protein kinase
VV02_RS14755	COG0076	glutamate decarboxylase activity
VV02_RS14760	COG3486	L-lysine 6-monooxygenase (NADPH) activity
VV02_RS14775	COG1881	PFAM PEBP family protein
VV02_RS14780	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
VV02_RS14790	COG2326	polyphosphate kinase activity
VV02_RS14820	COG1529	Aldehyde oxidase and xanthine dehydrogenase
VV02_RS14830	COG0590	tRNA wobble adenosine to inosine editing
VV02_RS14845	COG2267	carboxylic ester hydrolase activity
VV02_RS14885	COG0277	FAD linked oxidase domain protein
VV02_RS14905	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
VV02_RS14925	COG1522	sequence-specific DNA binding
VV02_RS14930	COG0626	cystathionine gamma-synthase activity
VV02_RS14955	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
VV02_RS14995	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
VV02_RS15000	COG1560	Kdo2-lipid A biosynthetic process
VV02_RS15005	COG0438	transferase activity, transferring glycosyl groups
VV02_RS15015	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
VV02_RS15035	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
VV02_RS15055	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
VV02_RS15060	COG3540	Alkaline phosphatase
VV02_RS15065	COG0217	transcriptional regulatory protein
VV02_RS15070	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
VV02_RS15075	COG0632	four-way junction helicase activity
VV02_RS15080	COG2255	four-way junction helicase activity
VV02_RS15090	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VV02_RS15095	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VV02_RS15100	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
VV02_RS15105	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
VV02_RS15115	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
VV02_RS15140	COG1362	aminopeptidase activity
VV02_RS15145	COG1196	nuclear chromosome segregation
VV02_RS15150	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
VV02_RS15160	COG0124	histidyl-tRNA synthetase
VV02_RS15165	COG1609	Transcriptional regulator
VV02_RS15190	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
VV02_RS15195	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
VV02_RS15210	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
VV02_RS15220	COG1160	GTP binding
VV02_RS15255	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
VV02_RS15260	COG1414	Transcriptional regulator
VV02_RS15275	COG0395	ABC-type sugar transport system, permease component
VV02_RS15280	COG1175	transmembrane transport
VV02_RS15290	COG3119	arylsulfatase activity
VV02_RS15295	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
VV02_RS15305	COG1262	PFAM Formylglycine-generating sulfatase enzyme
VV02_RS15340	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
VV02_RS15370	COG1716	ATPase activity
VV02_RS15390	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
VV02_RS15390	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
VV02_RS15410	COG0419	ATPase involved in DNA repair
VV02_RS15415	COG0420	3'-5' exonuclease activity
VV02_RS15425	COG3290	protein histidine kinase activity
VV02_RS15430	COG1301	dicarboxylic acid transport
VV02_RS15445	COG0406	alpha-ribazole phosphatase activity
VV02_RS15465	COG0009	L-threonylcarbamoyladenylate synthase
VV02_RS15475	COG0387	Pfam Sodium calcium exchanger
VV02_RS15505	COG4941	Belongs to the sigma-70 factor family
VV02_RS15510	COG3795	YCII-related domain
VV02_RS15525	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
VV02_RS15560	COG2154	pterin-4-alpha-carbinolamine dehydratase
VV02_RS15575	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
VV02_RS15595	COG1012	belongs to the aldehyde dehydrogenase family
VV02_RS15605	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
VV02_RS15625	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
VV02_RS15650	COG2318	DinB family
VV02_RS15660	COG1846	Transcriptional regulator
VV02_RS15670	COG1028	Short-chain dehydrogenase reductase Sdr
VV02_RS15715	COG1216	Glycosyl transferase, family 2
VV02_RS15725	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
VV02_RS15735	COG1522	sequence-specific DNA binding
VV02_RS15740	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VV02_RS15755	COG0805	protein transport
VV02_RS15760	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
VV02_RS15795	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
VV02_RS15815	COG1132	(ABC) transporter
VV02_RS15820	COG1132	(ABC) transporter
VV02_RS15825	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
VV02_RS15830	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
VV02_RS15840	COG4122	O-methyltransferase activity
VV02_RS15865	COG1222	aaa ATPase
VV02_RS15875	COG0517	IMP dehydrogenase activity
VV02_RS15875	COG1994	Peptidase M50
VV02_RS15895	COG2022	thiamine diphosphate biosynthetic process
VV02_RS15895	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VV02_RS15905	COG2022	thiamine diphosphate biosynthetic process
VV02_RS15910	COG0352	thiamine-phosphate diphosphorylase activity
VV02_RS15925	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
VV02_RS15930	COG0646	methionine synthase
VV02_RS15930	COG1410	methionine synthase
VV02_RS15945	COG0215	cysteine-tRNA ligase activity
VV02_RS15965	COG0598	Magnesium transport protein CorA
VV02_RS15980	COG2313	pseudouridylate synthase activity
VV02_RS15985	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VV02_RS15985	COG1522	sequence-specific DNA binding
VV02_RS15990	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
VV02_RS15995	COG0667	Aldo Keto reductase
VV02_RS16010	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
VV02_RS16015	COG1793	dna ligase
VV02_RS16020	COG2130	NADP-dependent
VV02_RS16060	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
VV02_RS16065	COG0604	alcohol dehydrogenase
VV02_RS16070	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
VV02_RS16075	COG1063	alcohol dehydrogenase
VV02_RS16100	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
VV02_RS16105	COG1793	dna ligase
VV02_RS16115	COG1793	dna ligase
VV02_RS16115	COG3285	dna ligase
VV02_RS16125	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VV02_RS16135	COG3253	May function as heme-dependent peroxidase
VV02_RS16140	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
VV02_RS16150	COG1309	transcriptional regulator
VV02_RS16165	COG2364	Membrane
VV02_RS16170	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
VV02_RS16190	COG0183	Belongs to the thiolase family
VV02_RS16195	COG1024	Enoyl-CoA hydratase
VV02_RS16195	COG1250	3-hydroxyacyl-CoA dehydrogenase
VV02_RS16200	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
VV02_RS16225	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
VV02_RS16255	COG0640	Transcriptional regulator
VV02_RS16275	COG0559	Belongs to the binding-protein-dependent transport system permease family
VV02_RS16300	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
VV02_RS16305	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
VV02_RS16310	COG0531	amino acid
VV02_RS16315	COG0569	domain protein
VV02_RS16335	COG0756	dUTP diphosphatase activity
VV02_RS16355	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
VV02_RS16360	COG2860	membrane
VV02_RS16370	COG2814	Major facilitator Superfamily
VV02_RS16375	COG1435	thymidine kinase activity
VV02_RS16390	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VV02_RS16390	COG1042	CoA-binding domain protein
VV02_RS16390	COG0045	succinate-CoA ligase (ADP-forming) activity
VV02_RS16400	COG1595	DNA-templated transcription, initiation
VV02_RS16405	COG0518	GMP synthase (glutamine-hydrolyzing) activity
VV02_RS16405	COG0519	Catalyzes the synthesis of GMP from XMP
VV02_RS16410	COG0778	Nitroreductase
VV02_RS16425	COG0537	adenosine 5'-monophosphoramidase activity
VV02_RS16440	COG1172	Belongs to the binding-protein-dependent transport system permease family
VV02_RS16460	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
VV02_RS16470	COG0531	amino acid
VV02_RS16490	COG0583	DNA-binding transcription factor activity
VV02_RS16495	COG1012	belongs to the aldehyde dehydrogenase family
VV02_RS16500	COG1063	alcohol dehydrogenase
VV02_RS16505	COG2271	Major facilitator Superfamily
VV02_RS16525	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
VV02_RS16535	COG0395	ABC-type sugar transport system, permease component
VV02_RS16555	COG1082	Xylose isomerase domain protein TIM barrel
VV02_RS16580	COG3525	Glycosyl hydrolase, family 20, catalytic domain
VV02_RS16600	COG4166	transmembrane transport
VV02_RS16605	COG0601	transmembrane transport
VV02_RS16610	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VV02_RS16615	COG0444	Belongs to the ABC transporter superfamily
VV02_RS16620	COG4608	Belongs to the ABC transporter superfamily
VV02_RS16635	COG1012	belongs to the aldehyde dehydrogenase family
VV02_RS16645	COG0306	phosphate transporter
VV02_RS16650	COG0583	DNA-binding transcription factor activity
VV02_RS16670	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
VV02_RS16680	COG2226	methyltransferase
VV02_RS16695	COG0187	DNA topoisomerase II activity
VV02_RS16735	COG0142	geranyltranstransferase activity
VV02_RS16765	COG0741	lytic transglycosylase activity
VV02_RS16770	COG2815	serine threonine protein kinase
VV02_RS16770	COG0515	serine threonine protein kinase
VV02_RS16775	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
VV02_RS16805	COG1940	carbohydrate kinase activity
VV02_RS16810	COG1940	carbohydrate kinase activity
VV02_RS16860	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
VV02_RS16870	COG1845	cytochrome c oxidase, subunit III
VV02_RS16875	COG2010	Cytochrome c
VV02_RS16880	COG0723	plastoquinol--plastocyanin reductase activity
VV02_RS16885	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
VV02_RS16895	COG0583	DNA-binding transcription factor activity
VV02_RS16910	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
VV02_RS16915	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
VV02_RS16925	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VV02_RS16955	COG0435	Glutathione S-transferase
VV02_RS16975	COG1278	Cold shock
VV02_RS16995	COG1131	(ABC) transporter
VV02_RS17000	COG4585	Histidine kinase
VV02_RS17005	COG2197	response regulator
VV02_RS17035	COG3845	ABC transporter
VV02_RS17050	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
VV02_RS17055	COG0404	The glycine cleavage system catalyzes the degradation of glycine
VV02_RS17060	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
VV02_RS17070	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VV02_RS17075	COG0508	dehydrogenase complex catalyzes the overall conversion of
VV02_RS17080	COG1090	epimerase
VV02_RS17090	COG0372	Belongs to the citrate synthase family
VV02_RS17100	COG0372	Belongs to the citrate synthase family
VV02_RS17110	COG1397	ADP-ribosylglycohydrolase
VV02_RS17115	COG0321	lipoyl(octanoyl) transferase activity
VV02_RS17120	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
VV02_RS17150	COG0174	glutamine synthetase
VV02_RS17155	COG3177	Filamentation induced by cAMP protein fic
VV02_RS17170	COG2226	methyltransferase
VV02_RS17205	COG1846	Transcriptional regulator
VV02_RS17210	COG0697	spore germination
VV02_RS17215	COG0395	ABC-type sugar transport system, permease component
VV02_RS17220	COG1175	transmembrane transport
VV02_RS17225	COG2182	Extracellular solute-binding protein
VV02_RS17235	COG0587	DNA-directed DNA polymerase activity
VV02_RS17245	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
VV02_RS17250	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
VV02_RS17265	COG1799	cell septum assembly
VV02_RS17270	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
VV02_RS17275	COG1496	oxidoreductase activity
VV02_RS17280	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
VV02_RS17285	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
VV02_RS17290	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
VV02_RS17295	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
VV02_RS17305	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
VV02_RS17310	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
VV02_RS17315	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
VV02_RS17320	COG0768	penicillin binding
VV02_RS17330	COG0275	rRNA processing
VV02_RS17335	COG2001	Belongs to the MraZ family
VV02_RS17340	COG0714	Associated with various cellular activities
VV02_RS17355	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
VV02_RS17360	COG0589	response to stress
VV02_RS17365	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
VV02_RS17405	COG0494	nUDIX hydrolase
VV02_RS17415	COG0537	adenosine 5'-monophosphoramidase activity
VV02_RS17430	COG1643	Atp-dependent helicase
VV02_RS17450	COG2826	transposase and inactivated derivatives, IS30 family
VV02_RS17460	COG2733	membrane
VV02_RS17485	COG1401	restriction endodeoxyribonuclease activity
VV02_RS17515	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VV02_RS17525	COG1960	acyl-CoA dehydrogenase activity
VV02_RS17545	COG0604	alcohol dehydrogenase
VV02_RS17560	COG4991	sh3 domain protein
VV02_RS17565	COG4991	sh3 domain protein
VV02_RS17595	COG0702	epimerase
VV02_RS17600	COG3540	Alkaline phosphatase
VV02_RS17610	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
VV02_RS17625	COG2409	Drug exporters of the RND superfamily
VV02_RS17630	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
VV02_RS17635	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
VV02_RS17645	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
VV02_RS17650	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
VV02_RS17655	COG0583	DNA-binding transcription factor activity
VV02_RS17660	COG0679	Auxin Efflux Carrier
VV02_RS17670	COG1555	photosystem II stabilization
VV02_RS17670	COG1596	polysaccharide export
VV02_RS17675	COG1307	EDD domain protein, DegV family
VV02_RS17680	COG0495	leucyl-tRNA aminoacylation
VV02_RS17685	COG0268	Binds directly to 16S ribosomal RNA
VV02_RS17730	COG1028	Short-chain dehydrogenase reductase Sdr
VV02_RS17730	COG3321	synthase
VV02_RS17730	COG0604	alcohol dehydrogenase
VV02_RS17735	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
VV02_RS17740	COG2340	Cysteine-rich secretory protein family
VV02_RS17755	COG2197	response regulator
VV02_RS17760	COG4585	Histidine kinase
VV02_RS17770	COG2813	Specifically methylates the guanine in position
VV02_RS17775	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
VV02_RS17780	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
VV02_RS17795	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
VV02_RS17800	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
VV02_RS17825	COG0180	Tryptophanyl-tRNA synthetase
VV02_RS17830	COG2814	Major facilitator Superfamily
VV02_RS17835	COG0583	DNA-binding transcription factor activity
VV02_RS17845	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
VV02_RS17880	COG3304	Inner membrane component domain
VV02_RS17890	COG0583	DNA-binding transcription factor activity
VV02_RS17905	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
VV02_RS17910	COG1305	Transglutaminase-like
VV02_RS17920	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
VV02_RS17925	COG2957	Belongs to the agmatine deiminase family
VV02_RS17930	COG1028	Short-chain dehydrogenase reductase Sdr
VV02_RS17935	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
VV02_RS17950	COG4935	Belongs to the peptidase S8 family
VV02_RS17950	COG2234	aminopeptidase activity
VV02_RS17970	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
VV02_RS17975	COG1201	RNA secondary structure unwinding
VV02_RS18000	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
VV02_RS18000	COG0473	3-isopropylmalate dehydrogenase activity
VV02_RS18005	COG4948	Mandelate Racemase Muconate Lactonizing
VV02_RS18010	COG2186	Transcriptional regulator
VV02_RS18015	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
VV02_RS18035	COG1297	OPT oligopeptide transporter protein
VV02_RS18040	COG1058	Belongs to the CinA family
VV02_RS18040	COG1546	Belongs to the CinA family
VV02_RS18050	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
VV02_RS18070	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
VV02_RS18075	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
VV02_RS18080	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
VV02_RS18115	COG1674	ftsk spoiiie
VV02_RS18145	COG4977	sequence-specific DNA binding
VV02_RS18150	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
VV02_RS18155	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
VV02_RS18160	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
VV02_RS18185	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
VV02_RS18190	COG2151	metal-sulfur cluster biosynthetic enzyme
VV02_RS18195	COG3396	Phenylacetate-CoA oxygenase
VV02_RS18200	COG3460	Phenylacetate-CoA oxygenase
VV02_RS18205	COG3396	Phenylacetate-CoA oxygenase
VV02_RS18240	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
VV02_RS18250	COG1185	polyribonucleotide nucleotidyltransferase activity
VV02_RS18255	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
VV02_RS18270	COG2376	Dihydroxyacetone kinase
VV02_RS18275	COG1461	Dihydroxyacetone kinase
VV02_RS18290	COG0105	UTP biosynthetic process
VV02_RS18295	COG1968	undecaprenyl-diphosphatase activity
VV02_RS18305	COG0285	dihydrofolate synthase activity
VV02_RS18315	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
VV02_RS18345	COG0277	FAD linked oxidase domain protein
VV02_RS18355	COG1953	Uracil, thiamine, allantoin
VV02_RS18360	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
VV02_RS18385	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
VV02_RS18400	COG0525	valine-tRNA ligase activity
VV02_RS18415	COG0714	Associated with various cellular activities
VV02_RS18445	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VV02_RS18450	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
VV02_RS18455	COG0740	serine-type endopeptidase activity
VV02_RS18460	COG0740	serine-type endopeptidase activity
VV02_RS18470	COG0544	peptidyl-prolyl cis-trans isomerase activity
VV02_RS18510	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VV02_RS18530	COG0668	transmembrane transport
VV02_RS18540	COG0366	Alpha amylase catalytic
VV02_RS18565	COG1946	Acyl-CoA thioesterase
VV02_RS18575	COG1090	epimerase
VV02_RS18580	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VV02_RS18595	COG0629	single-stranded DNA binding
VV02_RS18600	COG1619	proteins homologs of microcin C7 resistance protein MccF
VV02_RS18615	COG2837	iron assimilation
VV02_RS18625	COG0672	)-iron permease
VV02_RS18650	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
VV02_RS18660	COG1295	ribonuclease BN
VV02_RS18675	COG1063	alcohol dehydrogenase
VV02_RS18680	COG0156	8-amino-7-oxononanoate synthase activity
VV02_RS18700	COG3629	intracellular signal transduction
VV02_RS18700	COG3903	Transcriptional regulator
VV02_RS18705	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
VV02_RS18735	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VV02_RS18760	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
VV02_RS18765	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
VV02_RS18800	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
VV02_RS18805	COG0179	Fumarylacetoacetate (FAA) hydrolase
VV02_RS18825	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
VV02_RS18835	COG0561	phosphatase activity
VV02_RS18840	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
VV02_RS18845	COG0473	3-isopropylmalate dehydrogenase activity
VV02_RS18850	COG0604	alcohol dehydrogenase
VV02_RS18870	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
VV02_RS18875	COG0440	acetolactate synthase activity
VV02_RS18895	COG0129	dihydroxy-acid dehydratase activity
VV02_RS18900	COG0588	phosphoglycerate mutase activity
VV02_RS18905	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
VV02_RS18910	COG2133	pyrroloquinoline quinone binding
VV02_RS18925	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
VV02_RS18930	COG0154	amidase activity
VV02_RS18935	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
VV02_RS18975	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
VV02_RS18985	COG3345	alpha-galactosidase
VV02_RS19015	COG0482	sulfurtransferase activity
VV02_RS19045	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
VV02_RS19050	COG2086	electron transfer activity
VV02_RS19060	COG1024	Enoyl-CoA hydratase
VV02_RS19090	COG1874	Beta-galactosidase
VV02_RS19095	COG0395	ABC-type sugar transport system, permease component
VV02_RS19100	COG1175	transmembrane transport
VV02_RS19110	COG1609	Transcriptional regulator
VV02_RS19170	COG0366	Alpha amylase catalytic
VV02_RS19175	COG0366	Alpha amylase catalytic
VV02_RS19180	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
VV02_RS19245	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
VV02_RS19245	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
VV02_RS19285	COG0183	Belongs to the thiolase family
VV02_RS19290	COG0346	lactoylglutathione lyase activity
VV02_RS19295	COG3177	Filamentation induced by cAMP protein fic
VV02_RS19335	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
VV02_RS19340	COG0405	Gamma-glutamyltransferase
VV02_RS19360	COG0355	proton-transporting ATP synthase activity, rotational mechanism
VV02_RS19365	COG1652	LysM domain
VV02_RS19365	COG2823	Periplasmic or secreted lipoprotein
VV02_RS19380	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
VV02_RS19385	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
VV02_RS19390	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
VV02_RS19395	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
VV02_RS19400	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
VV02_RS19405	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
VV02_RS19410	COG0356	it plays a direct role in the translocation of protons across the membrane
VV02_RS19425	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
VV02_RS19430	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
VV02_RS19435	COG0009	L-threonylcarbamoyladenylate synthase
VV02_RS19465	COG1175	transmembrane transport
VV02_RS19485	COG0494	nUDIX hydrolase
VV02_RS19490	COG2890	protein-(glutamine-N5) methyltransferase activity
VV02_RS19495	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
VV02_RS19500	COG0254	rRNA binding
VV02_RS19540	COG0083	homoserine kinase activity
VV02_RS19545	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
VV02_RS19550	COG0460	homoserine dehydrogenase
VV02_RS19560	COG0018	arginyl-trna synthetase
VV02_RS19575	COG0395	ABC-type sugar transport system, permease component
VV02_RS19580	COG4209	transmembrane transport
VV02_RS19590	COG3345	alpha-galactosidase
VV02_RS19595	COG0673	inositol 2-dehydrogenase activity
VV02_RS19605	COG1609	Transcriptional regulator
VV02_RS19615	COG1175	transmembrane transport
VV02_RS19620	COG0395	ABC-type sugar transport system, permease component
VV02_RS19635	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
VV02_RS19640	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
VV02_RS19650	COG1104	cysteine desulfurase activity
VV02_RS19655	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
VV02_RS19665	COG1253	flavin adenine dinucleotide binding
VV02_RS19680	COG0508	dehydrogenase complex catalyzes the overall conversion of
VV02_RS19680	COG0567	Dehydrogenase, E1 component
VV02_RS19710	COG0765	amino acid transport
VV02_RS19765	COG1595	DNA-templated transcription, initiation
VV02_RS19770	COG1528	Iron-storage protein
VV02_RS19775	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
VV02_RS19785	COG2135	peptidase activity
VV02_RS19795	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
VV02_RS19800	COG1162	GTPase activity
VV02_RS19805	COG0483	inositol monophosphate 1-phosphatase activity
VV02_RS19835	COG1252	NADH dehydrogenase
VV02_RS19845	COG1716	ATPase activity
VV02_RS19845	COG1131	(ABC) transporter
VV02_RS19845	COG0842	Transport permease protein
VV02_RS19850	COG1012	belongs to the aldehyde dehydrogenase family
VV02_RS19860	COG0318	PFAM AMP-dependent synthetase and ligase
VV02_RS19870	COG1960	acyl-CoA dehydrogenase activity
VV02_RS19895	COG1131	(ABC) transporter
VV02_RS19920	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
VV02_RS19930	COG1615	UPF0182 protein
VV02_RS19945	COG3480	Lon protease (S16) C-terminal proteolytic domain
VV02_RS19985	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
VV02_RS19990	COG1335	isochorismatase
VV02_RS20005	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
VV02_RS20035	COG0431	NADPH-dependent FMN reductase
VV02_RS20050	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
VV02_RS20070	COG0210	DNA helicase
VV02_RS20100	COG2261	transglycosylase associated protein
VV02_RS20110	COG0513	Belongs to the DEAD box helicase family
VV02_RS20115	COG2197	response regulator
VV02_RS20130	COG1064	alcohol dehydrogenase
VV02_RS20135	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
VV02_RS20165	COG0006	proline dipeptidase activity
VV02_RS20185	COG2239	Acts as a magnesium transporter
VV02_RS20200	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
VV02_RS20220	COG1832	CoA-binding protein
VV02_RS20240	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
VV02_RS20250	COG1595	DNA-templated transcription, initiation
VV02_RS20255	COG4122	O-methyltransferase activity
VV02_RS20265	COG1024	Enoyl-CoA hydratase
VV02_RS20275	COG0519	Catalyzes the synthesis of GMP from XMP
VV02_RS20290	COG1611	Belongs to the LOG family
VV02_RS20295	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
VV02_RS20310	COG2171	N-acyltransferase activity
VV02_RS20350	COG0277	FAD linked oxidase domain protein
VV02_RS20350	COG0247	lactate metabolic process
VV02_RS20355	COG2720	vancomycin resistance protein
VV02_RS20360	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
VV02_RS20365	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
VV02_RS20370	COG1217	gtp-binding protein TYPA
VV02_RS20390	COG1051	belongs to the nudix hydrolase family
VV02_RS20395	COG3629	intracellular signal transduction
VV02_RS20395	COG3903	Transcriptional regulator
VV02_RS20400	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VV02_RS20405	COG0747	negative chemotaxis
VV02_RS20415	COG0444	Belongs to the ABC transporter superfamily
VV02_RS20420	COG4608	Belongs to the ABC transporter superfamily
VV02_RS20450	COG2264	protein methyltransferase activity
VV02_RS20465	COG2318	DinB family
VV02_RS20480	COG0456	acetyltransferase
VV02_RS20485	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
VV02_RS20490	COG1917	Cupin 2, conserved barrel domain protein
VV02_RS20495	COG5285	phytanoyl-CoA dioxygenase
VV02_RS20515	COG1960	acyl-CoA dehydrogenase activity
VV02_RS20540	COG0477	Major facilitator Superfamily
VV02_RS20545	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VV02_RS20570	COG0604	alcohol dehydrogenase
VV02_RS20585	COG0012	GTP binding
VV02_RS20615	COG1322	Protein conserved in bacteria
VV02_RS20625	COG0789	Transcriptional regulator
VV02_RS20630	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
VV02_RS20645	COG1278	Cold shock
VV02_RS20650	COG1570	exodeoxyribonuclease VII activity
VV02_RS20655	COG1722	exodeoxyribonuclease VII activity
VV02_RS20670	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VV02_RS20700	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
VV02_RS20700	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
VV02_RS20720	COG2345	Transcriptional regulator
VV02_RS20775	COG0531	amino acid
VV02_RS20785	COG1764	response to oxidative stress
VV02_RS20795	COG0436	Aminotransferase
VV02_RS20815	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
VV02_RS20820	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
VV02_RS20825	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
VV02_RS20835	COG2755	lipolytic protein G-D-S-L family
VV02_RS20835	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
VV02_RS20845	COG0488	(ABC) transporter
VV02_RS20860	COG0657	acetylesterase activity
VV02_RS20865	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
VV02_RS20870	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
VV02_RS20875	COG1984	allophanate hydrolase subunit 2
VV02_RS20880	COG0101	tRNA pseudouridine synthase activity
VV02_RS20905	COG0203	ribosomal protein L17
VV02_RS20910	COG0202	RNA polymerase activity
VV02_RS20920	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
VV02_RS20925	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
VV02_RS20930	COG0257	Belongs to the bacterial ribosomal protein bL36 family
VV02_RS20935	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
VV02_RS20940	COG4585	Histidine kinase
VV02_RS20945	COG2197	response regulator
VV02_RS20955	COG0563	adenylate kinase activity
VV02_RS20965	COG0200	Binds to the 23S rRNA
VV02_RS20970	COG1841	ribosomal large subunit assembly
VV02_RS20975	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
VV02_RS20980	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
VV02_RS20985	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
VV02_RS20990	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
VV02_RS20995	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
VV02_RS21000	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
VV02_RS21005	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
VV02_RS21010	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
VV02_RS21015	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
VV02_RS21025	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
VV02_RS21030	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
VV02_RS21035	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
VV02_RS21040	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
VV02_RS21045	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
VV02_RS21050	COG0089	rRNA binding
VV02_RS21055	COG0088	Forms part of the polypeptide exit tunnel
VV02_RS21060	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
VV02_RS21065	COG0051	transcription antitermination factor activity, RNA binding
VV02_RS21070	COG2186	Transcriptional regulator
VV02_RS21075	COG2807	transmembrane transport
VV02_RS21100	COG2356	endonuclease I
VV02_RS21125	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
VV02_RS21150	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VV02_RS21165	COG1492	cobalamin metabolic process
VV02_RS21170	COG2099	Precorrin-6x reductase
VV02_RS21175	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
VV02_RS21200	COG1797	cobyrinic acid a,c-diamide synthase activity
VV02_RS21205	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
VV02_RS21225	COG0789	Transcriptional regulator
VV02_RS21230	COG2814	Major facilitator Superfamily
VV02_RS21245	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
VV02_RS21275	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
VV02_RS21280	COG0049	tRNA binding
VV02_RS21285	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
VV02_RS21295	COG0463	Glycosyl transferase, family 2
VV02_RS21330	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
VV02_RS21335	COG0085	RNA polymerase activity
VV02_RS21345	COG1132	(ABC) transporter
VV02_RS21360	COG0222	ribosome binding
VV02_RS21395	COG1595	DNA-templated transcription, initiation
VV02_RS21400	COG1012	belongs to the aldehyde dehydrogenase family
VV02_RS21430	COG0464	growth
VV02_RS21440	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VV02_RS21465	COG1716	ATPase activity
VV02_RS21470	COG0081	regulation of translation
VV02_RS21475	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
VV02_RS21480	COG0250	Participates in transcription elongation, termination and antitermination
VV02_RS21500	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
VV02_RS21510	COG0812	UDP-N-acetylmuramate dehydrogenase activity
VV02_RS21520	COG2030	dehydratase
VV02_RS21525	COG0267	Belongs to the bacterial ribosomal protein bL33 family
VV02_RS21545	COG1028	Short-chain dehydrogenase reductase Sdr
VV02_RS21550	COG0183	Belongs to the thiolase family
VV02_RS21560	COG1501	Belongs to the glycosyl hydrolase 31 family
VV02_RS21605	COG1666	GTP binding
VV02_RS21645	COG1309	transcriptional regulator
VV02_RS21650	COG1960	acyl-CoA dehydrogenase activity
VV02_RS21655	COG1028	Short-chain dehydrogenase reductase Sdr
VV02_RS21665	COG1028	Short-chain dehydrogenase reductase Sdr
VV02_RS21695	COG0501	Belongs to the peptidase M48B family
VV02_RS21700	COG1007	ATP synthesis coupled electron transport
VV02_RS21715	COG0713	ATP synthesis coupled electron transport
VV02_RS21720	COG0839	Belongs to the complex I subunit 6 family
VV02_RS21725	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
VV02_RS21780	COG2226	methyltransferase
VV02_RS21790	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
VV02_RS21795	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
VV02_RS21800	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
VV02_RS21805	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
VV02_RS21840	COG0745	RESPONSE REGULATOR receiver
VV02_RS21845	COG5002	protein histidine kinase activity
VV02_RS21860	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
VV02_RS21865	COG2011	ABC-type metal ion transport system permease component
VV02_RS21875	COG1028	Short-chain dehydrogenase reductase Sdr
VV02_RS21895	COG0831	urea catabolic process
VV02_RS21900	COG0832	Belongs to the urease beta subunit family
VV02_RS21915	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
VV02_RS21920	COG0829	nickel cation binding
VV02_RS21930	COG0674	pyruvate-flavodoxin oxidoreductase activity
VV02_RS21930	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
VV02_RS21935	COG1013	pyruvate-flavodoxin oxidoreductase activity
VV02_RS21950	COG1960	acyl-CoA dehydrogenase activity
VV02_RS21960	COG1309	transcriptional regulator
VV02_RS21980	COG0142	geranyltranstransferase activity
VV02_RS21985	COG1007	ATP synthesis coupled electron transport
VV02_RS21995	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
VV02_RS22000	COG0713	ATP synthesis coupled electron transport
VV02_RS22005	COG0839	Belongs to the complex I subunit 6 family
VV02_RS22010	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
VV02_RS22015	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
VV02_RS22020	COG1034	ATP synthesis coupled electron transport
VV02_RS22035	COG0649	NAD binding
VV02_RS22040	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
VV02_RS22045	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
VV02_RS22060	COG2226	methyltransferase
VV02_RS22065	COG1169	isochorismate synthase
VV02_RS22075	COG4552	Acetyltransferase involved in intracellular survival and related
VV02_RS22080	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
VV02_RS22085	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
VV02_RS22110	COG2017	converts alpha-aldose to the beta-anomer
VV02_RS22115	COG0318	PFAM AMP-dependent synthetase and ligase
VV02_RS22125	COG2318	DinB family
VV02_RS22150	COG3590	peptidase
VV02_RS22155	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
VV02_RS22160	COG1061	Type III restriction enzyme res subunit
VV02_RS22165	COG0477	Major facilitator Superfamily
VV02_RS22170	COG0640	Transcriptional regulator
VV02_RS22180	COG2337	Toxic component of a toxin-antitoxin (TA) module
VV02_RS22185	COG2197	response regulator
VV02_RS22190	COG4585	Histidine kinase
VV02_RS22195	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
VV02_RS22205	COG0745	RESPONSE REGULATOR receiver
VV02_RS22220	COG0494	nUDIX hydrolase
VV02_RS22230	COG2252	PERMEase
VV02_RS22260	COG1278	Cold shock
VV02_RS22285	COG3214	Protein conserved in bacteria
VV02_RS22295	COG0477	Major facilitator Superfamily
VV02_RS22305	COG4585	Histidine kinase
VV02_RS22310	COG2197	response regulator
VV02_RS22320	COG1132	(ABC) transporter
VV02_RS22330	COG0183	Belongs to the thiolase family
VV02_RS22340	COG4948	Mandelate Racemase Muconate Lactonizing
VV02_RS22405	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
VV02_RS22415	COG0785	Cytochrome C biogenesis protein
VV02_RS22425	COG0406	alpha-ribazole phosphatase activity
VV02_RS22430	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
VV02_RS22435	COG1846	Transcriptional regulator
VV02_RS22440	COG2353	YceI-like domain
VV02_RS22445	COG1876	peptidase activity
VV02_RS22450	COG0113	porphobilinogen synthase activity
VV02_RS22455	COG1648	precorrin-2 dehydrogenase activity
VV02_RS22455	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
VV02_RS22465	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
VV02_RS22470	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
VV02_RS22495	COG0123	including yeast histone deacetylase and acetoin utilization protein
VV02_RS22505	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
VV02_RS22510	COG0506	proline dehydrogenase activity
VV02_RS22515	COG1305	Transglutaminase-like
VV02_RS22560	COG1082	Xylose isomerase domain protein TIM barrel
VV02_RS22565	COG0248	Ppx GppA phosphatase
VV02_RS22580	COG1595	DNA-templated transcription, initiation
VV02_RS22600	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
VV02_RS22605	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
VV02_RS22610	COG1280	lysine exporter protein (LysE YggA)
VV02_RS22615	COG2197	response regulator
VV02_RS22620	COG4585	Histidine kinase
VV02_RS22630	COG0577	efflux transmembrane transporter activity
VV02_RS22630	COG1136	(ABC) transporter
VV02_RS22640	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
VV02_RS22660	COG4214	carbohydrate transport
VV02_RS22675	COG3903	Transcriptional regulator
VV02_RS22675	COG3629	intracellular signal transduction
VV02_RS22685	COG3629	intracellular signal transduction
VV02_RS22685	COG3903	Transcriptional regulator
VV02_RS22700	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
VV02_RS22710	COG3876	Protein conserved in bacteria
VV02_RS22715	COG3265	gluconokinase activity
VV02_RS22730	COG1131	(ABC) transporter
VV02_RS22745	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
VV02_RS22765	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
VV02_RS22770	COG3285	dna ligase
VV02_RS22770	COG1793	dna ligase
VV02_RS22775	COG1793	dna ligase
VV02_RS22775	COG3285	dna ligase
VV02_RS22915	COG1674	ftsk spoiiie
VV02_RS22980	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
VV02_RS23015	COG0765	amino acid transport
VV02_RS23020	COG1126	abc transporter atp-binding protein
VV02_RS23025	COG0649	NAD binding
VV02_RS23040	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
VV02_RS23045	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
VV02_RS23050	COG0302	gtp cyclohydrolase
VV02_RS23055	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
VV02_RS23075	COG0037	tRNA processing
VV02_RS23085	COG2027	D-alanyl-D-alanine carboxypeptidase
VV02_RS23090	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
VV02_RS23110	COG0596	Alpha beta hydrolase
VV02_RS23165	COG2188	Transcriptional regulator
VV02_RS23215	COG0470	DNA polymerase III
VV02_RS23220	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
VV02_RS23225	COG0789	Transcriptional regulator
VV02_RS23255	COG0519	Catalyzes the synthesis of GMP from XMP
VV02_RS23280	COG1754	DNA topoisomerase type I activity
VV02_RS23280	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
VV02_RS23285	COG3384	dioxygenase
VV02_RS23305	COG2890	protein-(glutamine-N5) methyltransferase activity
VV02_RS23315	COG1366	Belongs to the anti-sigma-factor antagonist family
VV02_RS23320	COG1205	dead DEAH box helicase
VV02_RS23320	COG1111	helicase
VV02_RS23330	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
VV02_RS23390	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
VV02_RS23435	COG0589	response to stress
VV02_RS23455	COG3290	protein histidine kinase activity
VV02_RS23465	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
VV02_RS23480	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
VV02_RS23490	COG0596	Alpha beta hydrolase
VV02_RS23500	COG4941	Belongs to the sigma-70 factor family
VV02_RS23515	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
VV02_RS23550	COG0251	oxidation-reduction process
VV02_RS23555	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VV02_RS23575	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
VV02_RS23580	COG1610	YqeY-like protein
VV02_RS23585	COG1408	metallophosphoesterase
VV02_RS23595	COG1024	Enoyl-CoA hydratase
VV02_RS23650	COG0318	PFAM AMP-dependent synthetase and ligase
VV02_RS23660	COG0697	spore germination
VV02_RS23670	COG0745	RESPONSE REGULATOR receiver
VV02_RS23675	COG2205	protein histidine kinase activity
VV02_RS23685	COG0583	DNA-binding transcription factor activity
VV02_RS23695	COG1126	abc transporter atp-binding protein
VV02_RS23700	COG0765	amino acid transport
VV02_RS23725	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
VV02_RS23770	COG0433	COG0433 Predicted ATPase
VV02_RS23785	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
VV02_RS23810	COG1024	Enoyl-CoA hydratase
VV02_RS24015	COG0494	nUDIX hydrolase
VV02_RS24090	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
VV02_RS24100	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
VV02_RS24135	COG4264	IucA IucC family
VV02_RS24145	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
VV02_RS24185	COG4221	oxidoreductase activity
VV02_RS24210	COG0515	serine threonine protein kinase
VV02_RS24250	COG0640	Transcriptional regulator
VV02_RS24260	COG2197	response regulator
VV02_RS24270	COG0577	efflux transmembrane transporter activity
VV02_RS24270	COG1136	(ABC) transporter
VV02_RS24275	COG0577	efflux transmembrane transporter activity
VV02_RS24290	COG0508	dehydrogenase complex catalyzes the overall conversion of
VV02_RS24290	COG0596	Alpha beta hydrolase
VV02_RS24305	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
VV02_RS24335	COG0590	tRNA wobble adenosine to inosine editing
VV02_RS24335	COG0037	tRNA processing
VV02_RS24340	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
VV02_RS24375	COG0531	amino acid
VV02_RS24380	COG0242	peptide deformylase activity
VV02_RS24385	COG1122	ATPase activity
VV02_RS24395	COG0310	cobalt ion transport
VV02_RS24415	COG1073	alpha beta
VV02_RS24455	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VV02_RS24460	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VV02_RS24465	COG1120	ATPase activity
VV02_RS24515	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
VV02_RS24520	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
VV02_RS24540	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
VV02_RS24545	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
VV02_RS24550	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
VV02_RS24560	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
VV02_RS24575	COG0745	RESPONSE REGULATOR receiver
VV02_RS24580	COG2205	protein histidine kinase activity
VV02_RS24600	COG1316	TRANSCRIPTIONal
VV02_RS24610	COG1278	Cold shock
VV02_RS24645	COG0776	regulation of translation
VV02_RS24650	COG1045	serine acetyltransferase
VV02_RS24660	COG2181	nitrate reductase activity
VV02_RS24660	COG0247	lactate metabolic process
VV02_RS24665	COG0789	Transcriptional regulator
VV02_RS24705	COG1672	PFAM Archaeal ATPase
VV02_RS24705	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
VV02_RS24715	COG4106	trans-aconitate 2-methyltransferase activity
VV02_RS24765	COG1174	glycine betaine transport
VV02_RS24775	COG2267	carboxylic ester hydrolase activity
VV02_RS24780	COG0717	Belongs to the dCTP deaminase family
VV02_RS24795	COG0243	molybdopterin cofactor binding
VV02_RS24805	COG0735	belongs to the Fur family
VV02_RS24825	COG1028	Short-chain dehydrogenase reductase Sdr
VV02_RS24830	COG3191	aminopeptidase activity
VV02_RS24845	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VV02_RS24855	COG4166	transmembrane transport
VV02_RS24880	COG0204	Acyl-transferase
VV02_RS24895	COG0154	amidase activity
VV02_RS24900	COG0737	Belongs to the 5'-nucleotidase family
VV02_RS24910	COG1960	acyl-CoA dehydrogenase activity
VV02_RS24920	COG1120	ATPase activity
VV02_RS24925	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VV02_RS24930	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VV02_RS24935	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
VV02_RS24945	COG0318	PFAM AMP-dependent synthetase and ligase
VV02_RS24950	COG3268	Saccharopine dehydrogenase
VV02_RS24965	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
VV02_RS24970	COG2161	toxin-antitoxin pair type II binding
VV02_RS24975	COG4115	mRNA cleavage
VV02_RS24990	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
VV02_RS24995	COG1357	PFAM Pentapeptide repeats (8 copies)
VV02_RS25000	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
VV02_RS25055	COG2814	Major facilitator Superfamily
VV02_RS25110	COG0508	dehydrogenase complex catalyzes the overall conversion of
VV02_RS25115	COG0022	dehydrogenase e1 component
VV02_RS25140	COG1595	DNA-templated transcription, initiation
VV02_RS25155	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
VV02_RS25160	COG1950	PFAM Membrane protein of
VV02_RS25190	COG1250	3-hydroxyacyl-CoA dehydrogenase
VV02_RS25225	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
VV02_RS25230	COG2318	DinB family
VV02_RS25250	COG2076	Multidrug Resistance protein
VV02_RS25265	COG0018	arginyl-trna synthetase
VV02_RS25290	COG2226	methyltransferase
VV02_RS25295	COG1271	oxidase subunit
VV02_RS25300	COG1294	oxidase, subunit
VV02_RS25305	COG4988	ABC transporter
VV02_RS25335	COG2409	Drug exporters of the RND superfamily
VV02_RS25380	COG2357	RelA SpoT domain protein
VV02_RS25390	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
VV02_RS25395	COG2089	acid synthase
VV02_RS25400	COG0583	DNA-binding transcription factor activity
VV02_RS25410	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
VV02_RS25430	COG2197	response regulator
VV02_RS25435	COG4585	Histidine kinase
VV02_RS25450	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
VV02_RS25485	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
VV02_RS25510	COG4152	abc transporter atp-binding protein
VV02_RS25515	COG2197	response regulator
VV02_RS25520	COG4585	Histidine kinase
VV02_RS25535	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
VV02_RS25540	COG1597	lipid kinase activity
VV02_RS25550	COG1136	(ABC) transporter
VV02_RS25555	COG1136	(ABC) transporter
VV02_RS25580	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
VV02_RS25630	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
VV02_RS25635	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
VV02_RS25640	COG3257	ureidoglycine aminohydrolase activity
VV02_RS25675	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
VV02_RS25680	COG2026	Addiction module toxin, RelE StbE family
VV02_RS25685	COG2161	toxin-antitoxin pair type II binding
VV02_RS25745	COG0667	Aldo Keto reductase
VV02_RS25750	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
VV02_RS25755	COG1234	tRNA 3'-trailer cleavage
VV02_RS25785	COG0640	Transcriptional regulator