locus-tag	class	description
HHL09_RS00055	COG1215	transferase activity, transferring glycosyl groups
HHL09_RS00075	COG0546	phosphoglycolate phosphatase activity
HHL09_RS00090	COG1028	Short-chain dehydrogenase reductase Sdr
HHL09_RS00105	COG1388	LysM domain
HHL09_RS00105	COG4932	domain protein
HHL09_RS00190	COG1028	Short-chain dehydrogenase reductase Sdr
HHL09_RS00195	COG4566	intracellular signal transduction
HHL09_RS00200	COG2205	protein histidine kinase activity
HHL09_RS00220	COG0489	protein tyrosine kinase activity
HHL09_RS00250	COG0438	transferase activity, transferring glycosyl groups
HHL09_RS00255	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HHL09_RS00280	COG1216	Glycosyl transferase, family 2
HHL09_RS00300	COG0438	transferase activity, transferring glycosyl groups
HHL09_RS00320	COG0438	transferase activity, transferring glycosyl groups
HHL09_RS00325	COG0438	transferase activity, transferring glycosyl groups
HHL09_RS00330	COG0110	maltose O-acetyltransferase activity
HHL09_RS00335	COG0463	Glycosyl transferase, family 2
HHL09_RS00385	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HHL09_RS00395	COG1028	Short-chain dehydrogenase reductase Sdr
HHL09_RS00400	COG0583	DNA-binding transcription factor activity
HHL09_RS00465	COG0475	glutathione-regulated potassium exporter activity
HHL09_RS00490	COG5002	protein histidine kinase activity
HHL09_RS00495	COG0745	RESPONSE REGULATOR receiver
HHL09_RS00560	COG4591	ABC-type transport system involved in lipoprotein release permease component
HHL09_RS00620	COG0247	lactate metabolic process
HHL09_RS00625	COG0277	FAD linked oxidase domain protein
HHL09_RS00635	COG2115	Belongs to the xylose isomerase family
HHL09_RS00640	COG4977	sequence-specific DNA binding
HHL09_RS00690	COG1609	Transcriptional regulator
HHL09_RS00710	COG0714	Associated with various cellular activities
HHL09_RS00740	COG4977	sequence-specific DNA binding
HHL09_RS00740	COG1917	Cupin 2, conserved barrel domain protein
HHL09_RS00775	COG0590	tRNA wobble adenosine to inosine editing
HHL09_RS00785	COG2207	Transcriptional regulator
HHL09_RS00815	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HHL09_RS00820	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HHL09_RS00945	COG1131	(ABC) transporter
HHL09_RS00980	COG0612	Peptidase, M16
HHL09_RS00995	COG0346	lactoylglutathione lyase activity
HHL09_RS01005	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HHL09_RS01010	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HHL09_RS01015	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HHL09_RS01025	COG0714	Associated with various cellular activities
HHL09_RS01060	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HHL09_RS01065	COG0217	transcriptional regulatory protein
HHL09_RS01075	COG0180	Tryptophanyl-tRNA synthetase
HHL09_RS01080	COG4221	oxidoreductase activity
HHL09_RS01090	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HHL09_RS01115	COG3275	phosphorelay sensor kinase activity
HHL09_RS01120	COG3279	Response regulator of the LytR AlgR family
HHL09_RS01125	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HHL09_RS01130	COG1136	(ABC) transporter
HHL09_RS01135	COG0577	efflux transmembrane transporter activity
HHL09_RS01135	COG1136	(ABC) transporter
HHL09_RS01140	COG3119	arylsulfatase activity
HHL09_RS01145	COG3119	arylsulfatase activity
HHL09_RS01150	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HHL09_RS01155	COG3119	arylsulfatase activity
HHL09_RS01160	COG3119	arylsulfatase activity
HHL09_RS01190	COG0259	pyridoxamine-phosphate oxidase activity
HHL09_RS01265	COG0649	NAD binding
HHL09_RS01320	COG2183	response to ionizing radiation
HHL09_RS01335	COG2345	Transcriptional regulator
HHL09_RS01355	COG1733	regulation of RNA biosynthetic process
HHL09_RS01370	COG1904	glucuronate isomerase
HHL09_RS01380	COG2706	6-phosphogluconolactonase activity
HHL09_RS01445	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HHL09_RS01450	COG1496	oxidoreductase activity
HHL09_RS01455	COG1846	Transcriptional regulator
HHL09_RS01480	COG1621	beta-fructofuranosidase activity
HHL09_RS01485	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HHL09_RS01495	COG1764	response to oxidative stress
HHL09_RS01500	COG0300	oxidoreductase activity
HHL09_RS01525	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HHL09_RS01530	COG1929	Belongs to the glycerate kinase type-1 family
HHL09_RS01590	COG0456	acetyltransferase
HHL09_RS01590	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HHL09_RS01615	COG0438	transferase activity, transferring glycosyl groups
HHL09_RS01620	COG0561	phosphatase activity
HHL09_RS01635	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HHL09_RS01650	COG0138	bifunctional purine biosynthesis protein purh
HHL09_RS01655	COG0179	Fumarylacetoacetate (FAA) hydrolase
HHL09_RS01670	COG0475	glutathione-regulated potassium exporter activity
HHL09_RS01670	COG0589	response to stress
HHL09_RS01685	COG0343	queuine tRNA-ribosyltransferase activity
HHL09_RS01695	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HHL09_RS01695	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HHL09_RS01705	COG1469	GTP cyclohydrolase I activity
HHL09_RS01715	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HHL09_RS01720	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HHL09_RS01725	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HHL09_RS01730	COG0077	Prephenate dehydratase
HHL09_RS01730	COG1605	Chorismate mutase
HHL09_RS01755	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HHL09_RS01760	COG2322	membrane
HHL09_RS01775	COG0109	protoheme IX farnesyltransferase activity
HHL09_RS01785	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HHL09_RS01790	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HHL09_RS01805	COG0825	malonyl-CoA metabolic process
HHL09_RS01820	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HHL09_RS01830	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HHL09_RS01840	COG2949	membrane
HHL09_RS01845	COG1597	lipid kinase activity
HHL09_RS01850	COG0424	maF-like protein
HHL09_RS01855	COG0803	Belongs to the bacterial solute-binding protein 9 family
HHL09_RS01860	COG4585	Histidine kinase
HHL09_RS01865	COG2197	response regulator
HHL09_RS01880	COG3848	Pyruvate phosphate dikinase
HHL09_RS01880	COG0574	Belongs to the PEP-utilizing enzyme family
HHL09_RS01930	COG1045	serine acetyltransferase
HHL09_RS01935	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HHL09_RS01940	COG0560	Phosphoserine phosphatase
HHL09_RS01945	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HHL09_RS01950	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HHL09_RS01965	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HHL09_RS01965	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HHL09_RS01970	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HHL09_RS01985	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HHL09_RS01990	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HHL09_RS02025	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HHL09_RS02035	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HHL09_RS02040	COG0416	fatty acid biosynthetic process
HHL09_RS02080	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HHL09_RS02090	COG0471	metal ion transport
HHL09_RS02090	COG3273	potassium ion transport
HHL09_RS02095	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HHL09_RS02115	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HHL09_RS02150	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HHL09_RS02155	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HHL09_RS02170	COG0159	tryptophan synthase activity
HHL09_RS02175	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HHL09_RS02195	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HHL09_RS02200	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HHL09_RS02205	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HHL09_RS02215	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HHL09_RS02220	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HHL09_RS02230	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HHL09_RS02250	COG1546	Belongs to the CinA family
HHL09_RS02250	COG1058	Belongs to the CinA family
HHL09_RS02255	COG0799	negative regulation of ribosome biogenesis
HHL09_RS02265	COG3119	arylsulfatase activity
HHL09_RS02285	COG2962	Rard protein
HHL09_RS02330	COG5183	chlorophyll binding
HHL09_RS02330	COG2133	pyrroloquinoline quinone binding
HHL09_RS02340	COG0714	Associated with various cellular activities
HHL09_RS02345	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HHL09_RS02360	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HHL09_RS02390	COG0196	riboflavin kinase activity
HHL09_RS02425	COG4774	siderophore transport
HHL09_RS02430	COG3128	pkhd-type hydroxylase
HHL09_RS02460	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HHL09_RS02510	COG0028	Belongs to the TPP enzyme family
HHL09_RS02520	COG0440	acetolactate synthase activity
HHL09_RS02535	COG1388	LysM domain
HHL09_RS02535	COG5632	N-Acetylmuramoyl-L-alanine amidase
HHL09_RS02535	COG3409	Peptidoglycan-binding domain 1 protein
HHL09_RS02565	COG0714	Associated with various cellular activities
HHL09_RS02590	COG3685	Protein conserved in bacteria
HHL09_RS02625	COG0489	protein tyrosine kinase activity
HHL09_RS02625	COG3206	protein involved in exopolysaccharide biosynthesis
HHL09_RS02670	COG3507	Belongs to the glycosyl hydrolase 43 family
HHL09_RS02710	COG1733	regulation of RNA biosynthetic process
HHL09_RS02715	COG0702	epimerase
HHL09_RS02730	COG0363	glucosamine-6-phosphate deaminase activity
HHL09_RS02765	COG0640	Transcriptional regulator
HHL09_RS02775	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HHL09_RS02780	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HHL09_RS02790	COG1796	DNA polymerase
HHL09_RS02790	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HHL09_RS02795	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HHL09_RS02815	COG0772	Belongs to the SEDS family
HHL09_RS02825	COG0228	four-way junction DNA binding
HHL09_RS02830	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HHL09_RS02880	COG1121	(ABC) transporter
HHL09_RS02885	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HHL09_RS02895	COG3591	Belongs to the peptidase S1B family
HHL09_RS02895	COG1864	DNA RNA non-specific endonuclease
HHL09_RS02905	COG2115	Belongs to the xylose isomerase family
HHL09_RS02910	COG0704	Plays a role in the regulation of phosphate uptake
HHL09_RS02915	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HHL09_RS02925	COG0306	phosphate transporter
HHL09_RS02935	COG0105	UTP biosynthetic process
HHL09_RS02940	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HHL09_RS02960	COG0667	Aldo Keto reductase
HHL09_RS02975	COG0142	geranyltranstransferase activity
HHL09_RS03065	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HHL09_RS03070	COG0473	3-isopropylmalate dehydrogenase activity
HHL09_RS03080	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HHL09_RS03090	COG0084	hydrolase, TatD family'
HHL09_RS03140	COG3119	arylsulfatase activity
HHL09_RS03150	COG1132	(ABC) transporter
HHL09_RS03160	COG1570	exodeoxyribonuclease VII activity
HHL09_RS03165	COG0045	succinate-CoA ligase (ADP-forming) activity
HHL09_RS03180	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HHL09_RS03195	COG0657	acetylesterase activity
HHL09_RS03195	COG2755	lipolytic protein G-D-S-L family
HHL09_RS03200	COG0792	nuclease activity
HHL09_RS03225	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HHL09_RS03240	COG1090	epimerase
HHL09_RS03250	COG0778	Nitroreductase
HHL09_RS03295	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HHL09_RS03315	COG1012	belongs to the aldehyde dehydrogenase family
HHL09_RS03340	COG3386	PFAM SMP-30 Gluconolaconase
HHL09_RS03380	COG0488	(ABC) transporter
HHL09_RS03415	COG0571	ribonuclease III activity
HHL09_RS03425	COG1193	negative regulation of DNA recombination
HHL09_RS03430	COG2096	Adenosyltransferase
HHL09_RS03445	COG1674	ftsk spoiiie
HHL09_RS03465	COG2954	triphosphatase activity
HHL09_RS03470	COG1196	nuclear chromosome segregation
HHL09_RS03500	COG1131	(ABC) transporter
HHL09_RS03530	COG5564	TIM-barrel signal transduction protein
HHL09_RS03535	COG2207	Transcriptional regulator
HHL09_RS03555	COG0004	ammonium transporteR
HHL09_RS03565	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HHL09_RS03570	COG1940	carbohydrate kinase activity
HHL09_RS03575	COG5002	protein histidine kinase activity
HHL09_RS03580	COG0745	RESPONSE REGULATOR receiver
HHL09_RS03615	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HHL09_RS03630	COG2197	response regulator
HHL09_RS03635	COG1187	pseudouridine synthase activity
HHL09_RS03645	COG0101	tRNA pseudouridine synthase activity
HHL09_RS03650	COG1404	Belongs to the peptidase S8 family
HHL09_RS03660	COG2132	Multicopper oxidase
HHL09_RS03665	COG2304	oxidoreductase activity
HHL09_RS03690	COG1609	Transcriptional regulator
HHL09_RS03695	COG0471	metal ion transport
HHL09_RS03695	COG0490	domain, Protein
HHL09_RS03705	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HHL09_RS03715	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
HHL09_RS03775	COG0864	Transcriptional regulator
HHL09_RS03790	COG4176	ABC-type proline glycine betaine transport system permease component
HHL09_RS03795	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HHL09_RS03820	COG1720	tRNA m6t6A37 methyltransferase activity
HHL09_RS03840	COG1686	Belongs to the peptidase S11 family
HHL09_RS03845	COG0156	8-amino-7-oxononanoate synthase activity
HHL09_RS03850	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HHL09_RS03870	COG0515	serine threonine protein kinase
HHL09_RS03870	COG2815	serine threonine protein kinase
HHL09_RS03895	COG0515	serine threonine protein kinase
HHL09_RS03895	COG2815	serine threonine protein kinase
HHL09_RS03905	COG2186	Transcriptional regulator
HHL09_RS03910	COG1869	D-ribose catabolic process
HHL09_RS03915	COG1082	Xylose isomerase domain protein TIM barrel
HHL09_RS03920	COG1063	alcohol dehydrogenase
HHL09_RS03925	COG3265	gluconokinase activity
HHL09_RS03930	COG1028	Short-chain dehydrogenase reductase Sdr
HHL09_RS03935	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HHL09_RS03965	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HHL09_RS03980	COG2226	methyltransferase
HHL09_RS03985	COG3940	Belongs to the glycosyl hydrolase 43 family
HHL09_RS04010	COG1643	Atp-dependent helicase
HHL09_RS04055	COG1074	ATP-dependent DNA helicase activity
HHL09_RS04060	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HHL09_RS04070	COG0430	RNA-3'-phosphate cyclase activity
HHL09_RS04100	COG4650	regulator
HHL09_RS04110	COG1335	isochorismatase
HHL09_RS04115	COG0583	DNA-binding transcription factor activity
HHL09_RS04120	COG0673	inositol 2-dehydrogenase activity
HHL09_RS04150	COG0592	DNA-directed DNA polymerase activity
HHL09_RS04155	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HHL09_RS04160	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HHL09_RS04175	COG0504	CTP synthase activity
HHL09_RS04215	COG0326	Molecular chaperone. Has ATPase activity
HHL09_RS04220	COG0450	alkyl hydroperoxide reductase
HHL09_RS04240	COG1064	alcohol dehydrogenase
HHL09_RS04270	COG2223	nitrite transmembrane transporter activity
HHL09_RS04280	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HHL09_RS04295	COG0688	phosphatidylethanolamine metabolic process
HHL09_RS04300	COG2271	Major facilitator Superfamily
HHL09_RS04310	COG1609	Transcriptional regulator
HHL09_RS04320	COG4297	protein containing double-stranded beta helix domain
HHL09_RS04325	COG0435	Glutathione S-transferase
HHL09_RS04345	COG0754	glutathionylspermidine amidase activity
HHL09_RS04390	COG0203	ribosomal protein L17
HHL09_RS04395	COG0202	RNA polymerase activity
HHL09_RS04405	COG0415	Belongs to the DNA photolyase family
HHL09_RS04410	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HHL09_RS04415	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HHL09_RS04420	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HHL09_RS04445	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HHL09_RS04470	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HHL09_RS04475	COG0508	dehydrogenase complex catalyzes the overall conversion of
HHL09_RS04480	COG0022	dehydrogenase e1 component
HHL09_RS04480	COG0508	dehydrogenase complex catalyzes the overall conversion of
HHL09_RS04485	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HHL09_RS04490	COG1733	regulation of RNA biosynthetic process
HHL09_RS04505	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HHL09_RS04515	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HHL09_RS04535	COG0084	hydrolase, TatD family'
HHL09_RS04560	COG4585	Histidine kinase
HHL09_RS04565	COG2197	response regulator
HHL09_RS04580	COG1028	Short-chain dehydrogenase reductase Sdr
HHL09_RS04585	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HHL09_RS04595	COG0484	heat shock protein binding
HHL09_RS04615	COG1959	2 iron, 2 sulfur cluster binding
HHL09_RS04635	COG1595	DNA-templated transcription, initiation
HHL09_RS04680	COG1475	DNA binding
HHL09_RS04685	COG2234	aminopeptidase activity
HHL09_RS04705	COG2815	serine threonine protein kinase
HHL09_RS04705	COG0515	serine threonine protein kinase
HHL09_RS04710	COG1028	Short-chain dehydrogenase reductase Sdr
HHL09_RS04740	COG2197	response regulator
HHL09_RS04745	COG0438	transferase activity, transferring glycosyl groups
HHL09_RS04750	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
HHL09_RS04765	COG3842	ATPase activity
HHL09_RS04795	COG1609	Transcriptional regulator
HHL09_RS04815	COG1621	beta-fructofuranosidase activity
HHL09_RS04825	COG1595	DNA-templated transcription, initiation
HHL09_RS04870	COG1335	isochorismatase
HHL09_RS04890	COG2815	serine threonine protein kinase
HHL09_RS04890	COG0515	serine threonine protein kinase
HHL09_RS04895	COG0673	inositol 2-dehydrogenase activity
HHL09_RS04920	COG1335	isochorismatase
HHL09_RS04940	COG3685	Protein conserved in bacteria
HHL09_RS04970	COG2205	protein histidine kinase activity
HHL09_RS05000	COG0586	Pfam SNARE associated Golgi protein
HHL09_RS05005	COG0471	metal ion transport
HHL09_RS05010	COG1253	flavin adenine dinucleotide binding
HHL09_RS05020	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HHL09_RS05035	COG2084	Dehydrogenase
HHL09_RS05060	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HHL09_RS05060	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HHL09_RS05065	COG2885	chlorophyll binding
HHL09_RS05095	COG0114	fumarate hydratase activity
HHL09_RS05100	COG1028	Short-chain dehydrogenase reductase Sdr
HHL09_RS05105	COG1028	Short-chain dehydrogenase reductase Sdr
HHL09_RS05120	COG2204	response regulator
HHL09_RS05125	COG2205	protein histidine kinase activity
HHL09_RS05135	COG0494	nUDIX hydrolase
HHL09_RS05150	COG2151	metal-sulfur cluster biosynthetic enzyme
HHL09_RS05175	COG0322	excinuclease ABC activity
HHL09_RS05180	COG0811	peptide transport
HHL09_RS05185	COG0848	biopolymer transport protein
HHL09_RS05195	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
HHL09_RS05225	COG1802	Transcriptional regulator
HHL09_RS05225	COG4626	Terminase
HHL09_RS05240	COG0740	serine-type endopeptidase activity
HHL09_RS05325	COG3685	Protein conserved in bacteria
HHL09_RS05330	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HHL09_RS05440	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
HHL09_RS05490	COG2814	Major facilitator Superfamily
HHL09_RS05500	COG1609	Transcriptional regulator
HHL09_RS05505	COG1063	alcohol dehydrogenase
HHL09_RS05510	COG2271	Major facilitator Superfamily
HHL09_RS05515	COG1858	cytochrome C peroxidase
HHL09_RS05625	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HHL09_RS05655	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HHL09_RS05660	COG0137	argininosuccinate synthase activity
HHL09_RS05735	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HHL09_RS05750	COG3119	arylsulfatase activity
HHL09_RS05760	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HHL09_RS05765	COG0124	histidyl-tRNA synthetase
HHL09_RS05775	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HHL09_RS05830	COG4771	TonB-dependent receptor
HHL09_RS05860	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HHL09_RS05880	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HHL09_RS05910	COG0243	molybdopterin cofactor binding
HHL09_RS05945	COG4581	dead DEAH box helicase
HHL09_RS05950	COG0584	glycerophosphoryl diester phosphodiesterase
HHL09_RS05955	COG0584	glycerophosphoryl diester phosphodiesterase
HHL09_RS05960	COG2307	Protein conserved in bacteria
HHL09_RS05960	COG2308	Evidence 4 Homologs of previously reported genes of
HHL09_RS05990	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HHL09_RS06000	COG2264	protein methyltransferase activity
HHL09_RS06005	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HHL09_RS06010	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HHL09_RS06020	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HHL09_RS06100	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HHL09_RS06140	COG0297	glycogen (starch) synthase activity
HHL09_RS06155	COG1966	Carbon starvation protein
HHL09_RS06180	COG2207	Transcriptional regulator
HHL09_RS06180	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HHL09_RS06200	COG0348	domain, Protein
HHL09_RS06210	COG2010	Cytochrome c
HHL09_RS06220	COG3278	Belongs to the heme-copper respiratory oxidase family
HHL09_RS06315	COG1595	DNA-templated transcription, initiation
HHL09_RS06335	COG3119	arylsulfatase activity
HHL09_RS06395	COG3956	TIGRFAM MazG family protein
HHL09_RS06415	COG1595	DNA-templated transcription, initiation
HHL09_RS06420	COG0492	ferredoxin-NADP+ reductase activity
HHL09_RS06445	COG2382	esterase
HHL09_RS06445	COG3507	Belongs to the glycosyl hydrolase 43 family
HHL09_RS06445	COG3693	PFAM glycoside hydrolase, family 10
HHL09_RS06460	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HHL09_RS06480	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HHL09_RS06490	COG0505	Belongs to the CarA family
HHL09_RS06495	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HHL09_RS06545	COG0052	Belongs to the universal ribosomal protein uS2 family
HHL09_RS06550	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HHL09_RS06575	COG1324	tolerance protein
HHL09_RS06580	COG5002	protein histidine kinase activity
HHL09_RS06585	COG2204	response regulator
HHL09_RS06595	COG1722	exodeoxyribonuclease VII activity
HHL09_RS06600	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HHL09_RS06615	COG0656	L-ascorbic acid biosynthetic process
HHL09_RS06625	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HHL09_RS06625	COG2205	protein histidine kinase activity
HHL09_RS06630	COG4251	negative regulation of phosphorylation
HHL09_RS06635	COG4251	negative regulation of phosphorylation
HHL09_RS06640	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
HHL09_RS06670	COG4555	ABC transporter
HHL09_RS06705	COG0720	synthase
HHL09_RS06730	COG3119	arylsulfatase activity
HHL09_RS06740	COG0297	glycogen (starch) synthase activity
HHL09_RS06795	COG2197	response regulator
HHL09_RS06800	COG4585	Histidine kinase
HHL09_RS06845	COG2010	Cytochrome c
HHL09_RS06870	COG1028	Short-chain dehydrogenase reductase Sdr
HHL09_RS06880	COG1063	alcohol dehydrogenase
HHL09_RS06890	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HHL09_RS06905	COG1181	Belongs to the D-alanine--D-alanine ligase family
HHL09_RS06910	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HHL09_RS06915	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HHL09_RS06935	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HHL09_RS06940	COG0544	peptidyl-prolyl cis-trans isomerase activity
HHL09_RS06945	COG0740	serine-type endopeptidase activity
HHL09_RS06950	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HHL09_RS06955	COG3511	phospholipase C
HHL09_RS06960	COG0793	Belongs to the peptidase S41A family
HHL09_RS06965	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HHL09_RS06970	COG0546	phosphoglycolate phosphatase activity
HHL09_RS06990	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HHL09_RS07000	COG2358	TRAP transporter, solute receptor (TAXI family
HHL09_RS07040	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HHL09_RS07045	COG1131	(ABC) transporter
HHL09_RS07085	COG1450	Type ii and iii secretion system protein
HHL09_RS07095	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HHL09_RS07140	COG1120	ATPase activity
HHL09_RS07155	COG1082	Xylose isomerase domain protein TIM barrel
HHL09_RS07160	COG2315	Protein conserved in bacteria
HHL09_RS07165	COG0826	peptidase U32
HHL09_RS07195	COG0598	Magnesium transport protein CorA
HHL09_RS07250	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HHL09_RS07265	COG0793	Belongs to the peptidase S41A family
HHL09_RS07265	COG4946	Tricorn protease homolog
HHL09_RS07280	COG0006	proline dipeptidase activity
HHL09_RS07290	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HHL09_RS07295	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
HHL09_RS07300	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HHL09_RS07330	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HHL09_RS07345	COG1595	DNA-templated transcription, initiation
HHL09_RS07350	COG0714	Associated with various cellular activities
HHL09_RS07385	COG1301	dicarboxylic acid transport
HHL09_RS07410	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HHL09_RS07415	COG0594	ribonuclease P activity
HHL09_RS07420	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HHL09_RS07425	COG0706	membrane insertase activity
HHL09_RS07445	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HHL09_RS07450	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HHL09_RS07455	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
HHL09_RS07460	COG1196	nuclear chromosome segregation
HHL09_RS07460	COG3264	Mechanosensitive ion channel
HHL09_RS07465	COG2067	long-chain fatty acid transport protein
HHL09_RS07480	COG0545	Peptidyl-prolyl cis-trans isomerase
HHL09_RS07485	COG3123	guanosine phosphorylase activity
HHL09_RS07500	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HHL09_RS07510	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HHL09_RS07515	COG4303	Ethanolamine ammonia lyase large subunit
HHL09_RS07520	COG4302	ethanolamine ammonia-lyase activity
HHL09_RS07525	COG0745	RESPONSE REGULATOR receiver
HHL09_RS07530	COG2205	protein histidine kinase activity
HHL09_RS07555	COG1070	Carbohydrate kinase
HHL09_RS07565	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HHL09_RS07580	COG0673	inositol 2-dehydrogenase activity
HHL09_RS07585	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HHL09_RS07600	COG1254	Belongs to the acylphosphatase family
HHL09_RS07605	COG2095	MarC family integral membrane protein
HHL09_RS07610	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HHL09_RS07630	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HHL09_RS07640	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HHL09_RS07645	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HHL09_RS07650	COG5002	protein histidine kinase activity
HHL09_RS07650	COG2198	Histidine kinase
HHL09_RS07650	COG0784	Response regulator, receiver
HHL09_RS07655	COG3850	Histidine kinase
HHL09_RS07655	COG3437	response regulator, receiver
HHL09_RS07655	COG4999	Histidine kinase
HHL09_RS07655	COG2205	protein histidine kinase activity
HHL09_RS07705	COG1573	uracil-dna glycosylase
HHL09_RS07715	COG4191	Histidine kinase
HHL09_RS07740	COG4566	intracellular signal transduction
HHL09_RS07775	COG2326	polyphosphate kinase activity
HHL09_RS07780	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HHL09_RS07795	COG4178	(ABC) transporter
HHL09_RS07800	COG3459	Glycosyltransferase 36 associated
HHL09_RS07815	COG0058	SHG alpha-glucan phosphorylase activity
HHL09_RS07830	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HHL09_RS07840	COG2985	domain, Protein
HHL09_RS07840	COG0569	domain protein
HHL09_RS07850	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HHL09_RS07860	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HHL09_RS07890	COG4566	intracellular signal transduction
HHL09_RS07920	COG0457	Tetratricopeptide repeat
HHL09_RS07925	COG2814	Major facilitator Superfamily
HHL09_RS07970	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
HHL09_RS07975	COG1518	maintenance of DNA repeat elements
HHL09_RS08010	COG0546	phosphoglycolate phosphatase activity
HHL09_RS08020	COG0195	Participates in both transcription termination and antitermination
HHL09_RS08025	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HHL09_RS08030	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HHL09_RS08065	COG1132	(ABC) transporter
HHL09_RS08070	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HHL09_RS08075	COG4589	Belongs to the CDS family
HHL09_RS08085	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HHL09_RS08095	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HHL09_RS08100	COG3034	peptidoglycan biosynthetic process
HHL09_RS08140	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HHL09_RS08150	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HHL09_RS08160	COG3119	arylsulfatase activity
HHL09_RS08190	COG0156	8-amino-7-oxononanoate synthase activity
HHL09_RS08200	COG4948	Mandelate Racemase Muconate Lactonizing
HHL09_RS08205	COG5505	Protein of unknown function (DUF819)
HHL09_RS08210	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HHL09_RS08275	COG0457	Tetratricopeptide repeat
HHL09_RS08285	COG2133	pyrroloquinoline quinone binding
HHL09_RS08315	COG0442	prolyl-tRNA aminoacylation
HHL09_RS08330	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HHL09_RS08370	COG3738	Protein conserved in bacteria
HHL09_RS08385	COG0423	glycine-tRNA ligase activity
HHL09_RS08395	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HHL09_RS08415	COG1132	(ABC) transporter
HHL09_RS08435	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HHL09_RS08445	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HHL09_RS08460	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HHL09_RS08495	COG1253	flavin adenine dinucleotide binding
HHL09_RS08510	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HHL09_RS08510	COG4651	solute:proton antiporter activity
HHL09_RS08535	COG0583	DNA-binding transcription factor activity
HHL09_RS08545	COG0583	DNA-binding transcription factor activity
HHL09_RS08565	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HHL09_RS08585	COG0725	ABC transporter, periplasmic molybdate-binding protein
HHL09_RS08590	COG4149	molybdate abc transporter
HHL09_RS08605	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HHL09_RS08620	COG1575	Belongs to the MenA family. Type 1 subfamily
HHL09_RS08630	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HHL09_RS08650	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HHL09_RS08660	COG0330	HflC and HflK could
HHL09_RS08675	COG0318	PFAM AMP-dependent synthetase and ligase
HHL09_RS08720	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HHL09_RS08725	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HHL09_RS08730	COG1012	belongs to the aldehyde dehydrogenase family
HHL09_RS08740	COG1012	belongs to the aldehyde dehydrogenase family
HHL09_RS08780	COG0577	efflux transmembrane transporter activity
HHL09_RS08780	COG1136	(ABC) transporter
HHL09_RS08785	COG0577	efflux transmembrane transporter activity
HHL09_RS08790	COG1136	(ABC) transporter
HHL09_RS08795	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HHL09_RS08800	COG3540	Alkaline phosphatase
HHL09_RS08805	COG2252	PERMEase
HHL09_RS08830	COG3795	YCII-related domain
HHL09_RS08835	COG4941	Belongs to the sigma-70 factor family
HHL09_RS08840	COG0174	glutamine synthetase
HHL09_RS08845	COG0631	protein serine/threonine phosphatase activity
HHL09_RS08880	COG0640	Transcriptional regulator
HHL09_RS08885	COG0667	Aldo Keto reductase
HHL09_RS08890	COG1028	Short-chain dehydrogenase reductase Sdr
HHL09_RS08895	COG1064	alcohol dehydrogenase
HHL09_RS08900	COG1902	pentaerythritol trinitrate reductase activity
HHL09_RS08905	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HHL09_RS08920	COG2814	Major facilitator Superfamily
HHL09_RS08925	COG0583	DNA-binding transcription factor activity
HHL09_RS08930	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HHL09_RS08940	COG0475	glutathione-regulated potassium exporter activity
HHL09_RS09020	COG1136	(ABC) transporter
HHL09_RS09070	COG0429	hydrolase of the alpha beta-hydrolase fold
HHL09_RS09085	COG0556	nucleotide-excision repair
HHL09_RS09095	COG2382	esterase
HHL09_RS09125	COG2207	Transcriptional regulator
HHL09_RS09165	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HHL09_RS09175	COG1132	(ABC) transporter
HHL09_RS09340	COG1783	phage Terminase large subunit
HHL09_RS09345	COG3728	DNA packaging
HHL09_RS09345	COG5484	DNA packaging
HHL09_RS09365	COG0305	Participates in initiation and elongation during chromosome replication
HHL09_RS09490	COG2264	protein methyltransferase activity
HHL09_RS09495	COG0436	Aminotransferase
HHL09_RS09505	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HHL09_RS09555	COG0640	Transcriptional regulator
HHL09_RS09600	COG3386	PFAM SMP-30 Gluconolaconase
HHL09_RS09610	COG1733	regulation of RNA biosynthetic process
HHL09_RS09615	COG0860	N-Acetylmuramoyl-L-alanine amidase
HHL09_RS09620	COG0024	Methionine aminopeptidase
HHL09_RS09625	COG0563	adenylate kinase activity
HHL09_RS09635	COG0200	Binds to the 23S rRNA
HHL09_RS09640	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HHL09_RS09645	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HHL09_RS09650	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HHL09_RS09655	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HHL09_RS09660	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HHL09_RS09665	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HHL09_RS09670	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HHL09_RS09675	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HHL09_RS09680	COG0255	Belongs to the universal ribosomal protein uL29 family
HHL09_RS09685	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HHL09_RS09690	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HHL09_RS09695	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HHL09_RS09705	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HHL09_RS09710	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HHL09_RS09715	COG0089	rRNA binding
HHL09_RS09720	COG0088	Forms part of the polypeptide exit tunnel
HHL09_RS09725	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HHL09_RS09730	COG0051	transcription antitermination factor activity, RNA binding
HHL09_RS09735	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HHL09_RS09740	COG0049	tRNA binding
HHL09_RS09745	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HHL09_RS09750	COG3119	arylsulfatase activity
HHL09_RS09760	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HHL09_RS09765	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HHL09_RS09780	COG3608	succinylglutamate desuccinylase aspartoacylase
HHL09_RS09780	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HHL09_RS09800	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HHL09_RS09805	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HHL09_RS09810	COG3257	ureidoglycine aminohydrolase activity
HHL09_RS09815	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HHL09_RS09825	COG2351	hydroxyisourate hydrolase activity
HHL09_RS09855	COG0443	Heat shock 70 kDa protein
HHL09_RS09895	COG0583	DNA-binding transcription factor activity
HHL09_RS09900	COG1741	Belongs to the pirin family
HHL09_RS09935	COG2249	NAD(P)H dehydrogenase (quinone) activity
HHL09_RS09945	COG0655	NAD(P)H dehydrogenase (quinone) activity
HHL09_RS09970	COG3485	protocatechuate 3,4-dioxygenase
HHL09_RS09975	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HHL09_RS09995	COG3481	metal-dependent phosphohydrolase, HD sub domain
HHL09_RS10005	COG4191	Histidine kinase
HHL09_RS10025	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HHL09_RS10045	COG2226	methyltransferase
HHL09_RS10055	COG0372	Belongs to the citrate synthase family
HHL09_RS10060	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HHL09_RS10070	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HHL09_RS10075	COG0009	L-threonylcarbamoyladenylate synthase
HHL09_RS10090	COG1131	(ABC) transporter
HHL09_RS10100	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HHL09_RS10110	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HHL09_RS10120	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
HHL09_RS10120	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HHL09_RS10130	COG2274	protein secretion by the type I secretion system
HHL09_RS10130	COG3271	cysteine-type peptidase activity
HHL09_RS10135	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HHL09_RS10150	COG1611	Belongs to the LOG family
HHL09_RS10160	COG3142	Participates in the control of copper homeostasis
HHL09_RS10170	COG1012	belongs to the aldehyde dehydrogenase family
HHL09_RS10185	COG1609	Transcriptional regulator
HHL09_RS10210	COG0488	(ABC) transporter
HHL09_RS10230	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HHL09_RS10235	COG0793	Belongs to the peptidase S41A family
HHL09_RS10240	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HHL09_RS10250	COG0489	protein tyrosine kinase activity
HHL09_RS10275	COG2094	Belongs to the DNA glycosylase MPG family
HHL09_RS10285	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HHL09_RS10290	COG0564	pseudouridine synthase activity
HHL09_RS10295	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HHL09_RS10295	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HHL09_RS10315	COG0463	Glycosyl transferase, family 2
HHL09_RS10330	COG0642	Histidine kinase
HHL09_RS10340	COG2076	Multidrug Resistance protein
HHL09_RS10350	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HHL09_RS10365	COG0038	chloride channel
HHL09_RS10380	COG0156	8-amino-7-oxononanoate synthase activity
HHL09_RS10435	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HHL09_RS10440	COG1595	DNA-templated transcription, initiation
HHL09_RS10450	COG0154	amidase activity
HHL09_RS10460	COG1505	serine-type exopeptidase activity
HHL09_RS10500	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HHL09_RS10525	COG1172	Belongs to the binding-protein-dependent transport system permease family
HHL09_RS10530	COG1129	ABC transporter
HHL09_RS10550	COG4977	sequence-specific DNA binding
HHL09_RS10555	COG0235	Class ii aldolase
HHL09_RS10570	COG0328	RNA-DNA hybrid ribonuclease activity
HHL09_RS10590	COG2267	carboxylic ester hydrolase activity
HHL09_RS10615	COG0673	inositol 2-dehydrogenase activity
HHL09_RS10635	COG0101	tRNA pseudouridine synthase activity
HHL09_RS10745	COG0717	Belongs to the dCTP deaminase family
HHL09_RS10750	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HHL09_RS10750	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HHL09_RS10760	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HHL09_RS10765	COG2204	response regulator
HHL09_RS10785	COG0724	RNA recognition motif
HHL09_RS10790	COG0492	ferredoxin-NADP+ reductase activity
HHL09_RS10795	COG0583	DNA-binding transcription factor activity
HHL09_RS10800	COG1012	belongs to the aldehyde dehydrogenase family
HHL09_RS10815	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HHL09_RS10845	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HHL09_RS10850	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HHL09_RS10870	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HHL09_RS10890	COG1309	transcriptional regulator
HHL09_RS10920	COG0336	Belongs to the RNA methyltransferase TrmD family
HHL09_RS10975	COG0829	nickel cation binding
HHL09_RS10980	COG0436	Aminotransferase
HHL09_RS11000	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HHL09_RS11005	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HHL09_RS11040	COG1959	2 iron, 2 sulfur cluster binding
HHL09_RS11060	COG0254	rRNA binding
HHL09_RS11105	COG1733	regulation of RNA biosynthetic process
HHL09_RS11110	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HHL09_RS11120	COG0714	Associated with various cellular activities
HHL09_RS11130	COG1363	Peptidase, m42
HHL09_RS11155	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HHL09_RS11170	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HHL09_RS11175	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HHL09_RS11175	COG2755	lipolytic protein G-D-S-L family
HHL09_RS11185	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HHL09_RS11190	COG2197	response regulator
HHL09_RS11240	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
HHL09_RS11255	COG2197	response regulator
HHL09_RS11285	COG2813	Specifically methylates the guanine in position
HHL09_RS11300	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HHL09_RS11320	COG2909	trisaccharide binding
HHL09_RS11345	COG1309	transcriptional regulator
HHL09_RS11355	COG0481	GTPase activity
HHL09_RS11360	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HHL09_RS11370	COG0724	RNA recognition motif
HHL09_RS11390	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HHL09_RS11395	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HHL09_RS11430	COG1172	Belongs to the binding-protein-dependent transport system permease family
HHL09_RS11435	COG1129	ABC transporter
HHL09_RS11440	COG4952	isomerase
HHL09_RS11465	COG3401	FG-GAP repeat protein
HHL09_RS11495	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HHL09_RS11525	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
HHL09_RS11540	COG0730	response to heat
HHL09_RS11550	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HHL09_RS11585	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HHL09_RS11600	COG0513	Belongs to the DEAD box helicase family
HHL09_RS11605	COG1012	belongs to the aldehyde dehydrogenase family
HHL09_RS11610	COG0783	Belongs to the Dps family
HHL09_RS11620	COG1597	lipid kinase activity
HHL09_RS11630	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HHL09_RS11670	COG5507	3-demethylubiquinone-9 3-methyltransferase
HHL09_RS11685	COG1573	uracil-dna glycosylase
HHL09_RS11710	COG0583	DNA-binding transcription factor activity
HHL09_RS11740	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HHL09_RS11755	COG0616	signal peptide processing
HHL09_RS11760	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HHL09_RS11805	COG0495	leucyl-tRNA aminoacylation
HHL09_RS11810	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HHL09_RS11820	COG0500	methyltransferase
HHL09_RS11825	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HHL09_RS11895	COG1091	dTDP-4-dehydrorhamnose reductase activity
HHL09_RS11910	COG3977	Valine--pyruvate aminotransferase
HHL09_RS11925	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HHL09_RS11935	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HHL09_RS11940	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HHL09_RS11945	COG0802	atpase or kinase
HHL09_RS11960	COG0534	Mate efflux family protein
HHL09_RS11990	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HHL09_RS12000	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HHL09_RS12020	COG0861	Integral membrane protein TerC family
HHL09_RS12030	COG0346	lactoylglutathione lyase activity
HHL09_RS12060	COG1970	mechanosensitive ion channel activity
HHL09_RS12080	COG0347	Belongs to the P(II) protein family
HHL09_RS12090	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HHL09_RS12095	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HHL09_RS12115	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HHL09_RS12130	COG0277	FAD linked oxidase domain protein
HHL09_RS12135	COG2197	response regulator
HHL09_RS12165	COG0352	thiamine-phosphate diphosphorylase activity
HHL09_RS12170	COG0439	Biotin carboxylase
HHL09_RS12175	COG0511	ligase activity, forming carbon-carbon bonds
HHL09_RS12180	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HHL09_RS12185	COG2333	competence protein COMEC
HHL09_RS12185	COG0658	competence protein
HHL09_RS12210	COG3119	arylsulfatase activity
HHL09_RS12250	COG0456	acetyltransferase
HHL09_RS12280	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HHL09_RS12285	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
HHL09_RS12295	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HHL09_RS12300	COG1335	isochorismatase
HHL09_RS12315	COG1127	ABC transporter
HHL09_RS12350	COG2208	phosphoserine phosphatase activity
HHL09_RS12365	COG1663	tetraacyldisaccharide 4'-kinase activity
HHL09_RS12395	COG2133	pyrroloquinoline quinone binding
HHL09_RS12435	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HHL09_RS12440	COG0778	Nitroreductase
HHL09_RS12460	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HHL09_RS12460	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HHL09_RS12470	COG0339	signal peptide processing
HHL09_RS12475	COG0194	GDP metabolic process
HHL09_RS12485	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HHL09_RS12510	COG3940	Belongs to the glycosyl hydrolase 43 family
HHL09_RS12520	COG3738	Protein conserved in bacteria
HHL09_RS12550	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HHL09_RS12555	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HHL09_RS12580	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HHL09_RS12585	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HHL09_RS12595	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HHL09_RS12600	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HHL09_RS12605	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HHL09_RS12610	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HHL09_RS12615	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HHL09_RS12620	COG0356	it plays a direct role in the translocation of protons across the membrane
HHL09_RS12650	COG4774	siderophore transport
HHL09_RS12680	COG0508	dehydrogenase complex catalyzes the overall conversion of
HHL09_RS12695	COG0508	dehydrogenase complex catalyzes the overall conversion of
HHL09_RS12695	COG0022	dehydrogenase e1 component
HHL09_RS12700	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HHL09_RS12710	COG0295	cytidine deaminase activity
HHL09_RS12715	COG0445	tRNA wobble uridine modification
HHL09_RS12750	COG2815	serine threonine protein kinase
HHL09_RS12750	COG0515	serine threonine protein kinase
HHL09_RS12765	COG0515	serine threonine protein kinase
HHL09_RS12765	COG2815	serine threonine protein kinase
HHL09_RS12775	COG1073	alpha beta
HHL09_RS12780	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HHL09_RS12800	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HHL09_RS12805	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HHL09_RS12810	COG0644	oxidoreductase
HHL09_RS12815	COG0644	oxidoreductase
HHL09_RS12850	COG2211	Major facilitator Superfamily
HHL09_RS12855	COG0673	inositol 2-dehydrogenase activity
HHL09_RS12860	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HHL09_RS12870	COG4591	ABC-type transport system involved in lipoprotein release permease component
HHL09_RS12905	COG1322	Protein conserved in bacteria
HHL09_RS12910	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HHL09_RS12920	COG5434	Belongs to the glycosyl hydrolase 28 family
HHL09_RS12925	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HHL09_RS12930	COG0583	DNA-binding transcription factor activity
HHL09_RS12965	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HHL09_RS12965	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HHL09_RS12980	COG2197	response regulator
HHL09_RS12985	COG1028	Short-chain dehydrogenase reductase Sdr
HHL09_RS13005	COG0753	catalase activity
HHL09_RS13035	COG0386	Belongs to the glutathione peroxidase family
HHL09_RS13040	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HHL09_RS13095	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HHL09_RS13145	COG2217	Heavy metal translocating P-type atpase
HHL09_RS13160	COG2132	Multicopper oxidase
HHL09_RS13180	COG3591	Belongs to the peptidase S1B family
HHL09_RS13185	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HHL09_RS13200	COG2133	pyrroloquinoline quinone binding
HHL09_RS13205	COG2133	pyrroloquinoline quinone binding
HHL09_RS13210	COG0735	belongs to the Fur family
HHL09_RS13215	COG0396	ATPase activity
HHL09_RS13220	COG0783	Belongs to the Dps family
HHL09_RS13225	COG0719	Fe-S assembly protein
HHL09_RS13230	COG0719	Fe-S assembly protein
HHL09_RS13275	COG0647	UMP catabolic process
HHL09_RS13280	COG3541	Predicted nucleotidyltransferase
HHL09_RS13290	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HHL09_RS13330	COG1131	(ABC) transporter
HHL09_RS13345	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HHL09_RS13365	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HHL09_RS13375	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HHL09_RS13395	COG0583	DNA-binding transcription factor activity
HHL09_RS13405	COG0701	Predicted permease
HHL09_RS13415	COG2217	Heavy metal translocating P-type atpase
HHL09_RS13425	COG1760	l-serine dehydratase
HHL09_RS13430	COG3135	benzoate transporter
HHL09_RS13445	COG2890	protein-(glutamine-N5) methyltransferase activity
HHL09_RS13460	COG3174	membrane
HHL09_RS13465	COG2723	6-phospho-beta-galactosidase activity
HHL09_RS13475	COG4580	involved in the transport of maltose and maltodextrins
HHL09_RS13490	COG0527	aspartate kinase activity
HHL09_RS13510	COG1611	Belongs to the LOG family
HHL09_RS13535	COG2239	Acts as a magnesium transporter
HHL09_RS13550	COG0860	N-Acetylmuramoyl-L-alanine amidase
HHL09_RS13575	COG0590	tRNA wobble adenosine to inosine editing
HHL09_RS13585	COG0776	regulation of translation
HHL09_RS13590	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HHL09_RS13605	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HHL09_RS13615	COG4771	TonB-dependent receptor
HHL09_RS13660	COG2080	2 iron, 2 sulfur cluster binding
HHL09_RS13665	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HHL09_RS13670	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HHL09_RS13675	COG4654	Cytochrome c, class I
HHL09_RS13700	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HHL09_RS13715	COG0277	FAD linked oxidase domain protein
HHL09_RS13730	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HHL09_RS13785	COG2154	pterin-4-alpha-carbinolamine dehydratase
HHL09_RS13815	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HHL09_RS13825	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HHL09_RS13835	COG0584	glycerophosphoryl diester phosphodiesterase
HHL09_RS13840	COG0191	fructose-bisphosphate aldolase activity
HHL09_RS13855	COG0667	Aldo Keto reductase
HHL09_RS13860	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
HHL09_RS13870	COG2721	sulfolactate sulfo-lyase activity
HHL09_RS13875	COG0246	Mannitol dehydrogenase
HHL09_RS13890	COG0784	Response regulator, receiver
HHL09_RS13890	COG5002	protein histidine kinase activity
HHL09_RS13890	COG2198	Histidine kinase
HHL09_RS13895	COG3237	CsbD-like
HHL09_RS13930	COG0514	ATP-dependent DNA helicase (RecQ)
HHL09_RS13970	COG1404	Belongs to the peptidase S8 family
HHL09_RS13980	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HHL09_RS13985	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HHL09_RS14000	COG1968	undecaprenyl-diphosphatase activity
HHL09_RS14005	COG0739	heme binding
HHL09_RS14080	COG0134	indole-3-glycerol-phosphate synthase activity
HHL09_RS14100	COG1649	PFAM Uncharacterised BCR, COG1649
HHL09_RS14120	COG0058	SHG alpha-glucan phosphorylase activity
HHL09_RS14150	COG0831	urea catabolic process
HHL09_RS14155	COG0832	Belongs to the urease beta subunit family
HHL09_RS14160	COG0804	urea catabolic process
HHL09_RS14175	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HHL09_RS14190	COG2815	serine threonine protein kinase
HHL09_RS14190	COG0515	serine threonine protein kinase
HHL09_RS14195	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HHL09_RS14215	COG2261	transglycosylase associated protein
HHL09_RS14225	COG0037	tRNA processing
HHL09_RS14225	COG0590	tRNA wobble adenosine to inosine editing
HHL09_RS14230	COG0657	acetylesterase activity
HHL09_RS14230	COG2755	lipolytic protein G-D-S-L family
HHL09_RS14235	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HHL09_RS14240	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HHL09_RS14290	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HHL09_RS14295	COG0123	including yeast histone deacetylase and acetoin utilization protein
HHL09_RS14305	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HHL09_RS14325	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HHL09_RS14340	COG1063	alcohol dehydrogenase
HHL09_RS14365	COG0521	Mo-molybdopterin cofactor biosynthetic process
HHL09_RS14370	COG0315	cyclic pyranopterin monophosphate synthase activity
HHL09_RS14370	COG0521	Mo-molybdopterin cofactor biosynthetic process
HHL09_RS14375	COG0303	'Molybdopterin
HHL09_RS14390	COG0436	Aminotransferase
HHL09_RS14475	COG0641	radical SAM
HHL09_RS14500	COG4797	methyltransferase
HHL09_RS14500	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HHL09_RS14515	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HHL09_RS14530	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HHL09_RS14540	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HHL09_RS14545	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HHL09_RS14545	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HHL09_RS14550	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
HHL09_RS14570	COG0438	transferase activity, transferring glycosyl groups
HHL09_RS14570	COG1216	Glycosyl transferase, family 2
HHL09_RS14590	COG0438	transferase activity, transferring glycosyl groups
HHL09_RS14610	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HHL09_RS14610	COG2755	lipolytic protein G-D-S-L family
HHL09_RS14645	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HHL09_RS14665	COG0438	transferase activity, transferring glycosyl groups
HHL09_RS14670	COG0110	maltose O-acetyltransferase activity
HHL09_RS14690	COG0438	transferase activity, transferring glycosyl groups
HHL09_RS14715	COG1216	Glycosyl transferase, family 2
HHL09_RS14730	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HHL09_RS14740	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HHL09_RS14745	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HHL09_RS14750	COG0193	aminoacyl-tRNA hydrolase activity
HHL09_RS14755	COG0360	Binds together with S18 to 16S ribosomal RNA
HHL09_RS14760	COG0629	single-stranded DNA binding
HHL09_RS14765	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HHL09_RS14775	COG0083	homoserine kinase activity
HHL09_RS14785	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HHL09_RS14800	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HHL09_RS14810	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HHL09_RS14815	COG0590	tRNA wobble adenosine to inosine editing
HHL09_RS14830	COG0346	lactoylglutathione lyase activity
HHL09_RS14860	COG3682	Transcriptional regulator
HHL09_RS14870	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HHL09_RS14895	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HHL09_RS14915	COG0657	acetylesterase activity
HHL09_RS14920	COG0107	imidazoleglycerol-phosphate synthase activity
HHL09_RS14925	COG0724	RNA recognition motif
HHL09_RS14930	COG4956	integral membrane protein (PIN domain superfamily)
HHL09_RS14940	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HHL09_RS14940	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HHL09_RS14945	COG0860	N-Acetylmuramoyl-L-alanine amidase
HHL09_RS14945	COG1388	LysM domain
HHL09_RS14955	COG0066	3-isopropylmalate dehydratase activity
HHL09_RS14960	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HHL09_RS14970	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HHL09_RS14990	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HHL09_RS14995	COG0697	spore germination
HHL09_RS15000	COG4628	conserved protein (DUF2132)
HHL09_RS15060	COG0205	6-phosphofructokinase activity
HHL09_RS15075	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HHL09_RS15125	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HHL09_RS15180	COG2244	polysaccharide biosynthetic process
HHL09_RS15185	COG1215	transferase activity, transferring glycosyl groups
HHL09_RS15200	COG1088	dTDP-glucose 4,6-dehydratase activity
HHL09_RS15210	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
HHL09_RS15240	COG1940	carbohydrate kinase activity
HHL09_RS15245	COG0800	Aldolase
HHL09_RS15260	COG1609	Transcriptional regulator
HHL09_RS15270	COG1028	Short-chain dehydrogenase reductase Sdr
HHL09_RS15275	COG3119	arylsulfatase activity
HHL09_RS15300	COG3119	arylsulfatase activity
HHL09_RS15340	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HHL09_RS15355	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HHL09_RS15365	COG0673	inositol 2-dehydrogenase activity
HHL09_RS15375	COG1595	DNA-templated transcription, initiation
HHL09_RS15385	COG1217	gtp-binding protein TYPA
HHL09_RS15395	COG1309	transcriptional regulator
HHL09_RS15405	COG2814	Major facilitator Superfamily
HHL09_RS15420	COG2197	response regulator
HHL09_RS15440	COG0698	ribose 5-phosphate isomerase
HHL09_RS15445	COG0406	alpha-ribazole phosphatase activity
HHL09_RS15455	COG0346	lactoylglutathione lyase activity
HHL09_RS15460	COG1764	response to oxidative stress
HHL09_RS15480	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HHL09_RS15485	COG1028	Short-chain dehydrogenase reductase Sdr
HHL09_RS15500	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
HHL09_RS15500	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
HHL09_RS15505	COG1199	ATP-dependent helicase activity
HHL09_RS15545	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HHL09_RS15585	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HHL09_RS15595	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HHL09_RS15600	COG0187	DNA topoisomerase II activity
HHL09_RS15605	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HHL09_RS15610	COG3119	arylsulfatase activity
HHL09_RS15625	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
HHL09_RS15640	COG0842	Transport permease protein
HHL09_RS15645	COG0842	Transport permease protein
HHL09_RS15650	COG1131	(ABC) transporter
HHL09_RS15655	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HHL09_RS15660	COG1309	transcriptional regulator
HHL09_RS15675	COG0557	exoribonuclease II activity
HHL09_RS15690	COG0745	RESPONSE REGULATOR receiver
HHL09_RS15735	COG1482	cell wall glycoprotein biosynthetic process
HHL09_RS15745	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HHL09_RS15780	COG1131	(ABC) transporter
HHL09_RS15780	COG1716	ATPase activity
HHL09_RS15780	COG0842	Transport permease protein
HHL09_RS15800	COG0316	Belongs to the HesB IscA family
HHL09_RS15820	COG0352	thiamine-phosphate diphosphorylase activity
HHL09_RS15820	COG0351	phosphomethylpyrimidine kinase
HHL09_RS15825	COG0745	RESPONSE REGULATOR receiver
HHL09_RS15830	COG5002	protein histidine kinase activity
HHL09_RS15865	COG4178	(ABC) transporter
HHL09_RS15905	COG0657	acetylesterase activity
HHL09_RS15920	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HHL09_RS15930	COG2204	response regulator
HHL09_RS15945	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HHL09_RS15950	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HHL09_RS15995	COG3119	arylsulfatase activity
HHL09_RS16000	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HHL09_RS16000	COG0574	Belongs to the PEP-utilizing enzyme family
HHL09_RS16055	COG0612	Peptidase, M16
HHL09_RS16070	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HHL09_RS16080	COG1137	ATPase activity
HHL09_RS16090	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HHL09_RS16115	COG0606	chelatase, subunit chli
HHL09_RS16125	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
HHL09_RS16140	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
HHL09_RS16140	COG2066	Belongs to the glutaminase family
HHL09_RS16180	COG3940	Belongs to the glycosyl hydrolase 43 family
HHL09_RS16195	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HHL09_RS16195	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HHL09_RS16210	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HHL09_RS16235	COG0242	peptide deformylase activity
HHL09_RS16265	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HHL09_RS16270	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HHL09_RS16310	COG2897	thiosulfate sulfurtransferase activity
HHL09_RS16315	COG0459	protein refolding
HHL09_RS16320	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HHL09_RS16330	COG0443	Heat shock 70 kDa protein
HHL09_RS16360	COG1902	pentaerythritol trinitrate reductase activity
HHL09_RS16365	COG0693	protein deglycase activity
HHL09_RS16370	COG0583	DNA-binding transcription factor activity
HHL09_RS16425	COG1872	DUF167
HHL09_RS16440	COG3119	arylsulfatase activity
HHL09_RS16475	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HHL09_RS16480	COG0483	inositol monophosphate 1-phosphatase activity
HHL09_RS16485	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HHL09_RS16535	COG0537	adenosine 5'-monophosphoramidase activity
HHL09_RS16545	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HHL09_RS16555	COG0632	four-way junction helicase activity
HHL09_RS16565	COG0705	Rhomboid family
HHL09_RS16580	COG0318	PFAM AMP-dependent synthetase and ligase
HHL09_RS16635	COG5002	protein histidine kinase activity
HHL09_RS16640	COG0133	tryptophan synthase activity
HHL09_RS16655	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HHL09_RS16675	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HHL09_RS16715	COG1285	pathogenesis
HHL09_RS16720	COG3685	Protein conserved in bacteria
HHL09_RS16730	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HHL09_RS16740	COG1028	Short-chain dehydrogenase reductase Sdr
HHL09_RS16745	COG5001	Diguanylate cyclase
HHL09_RS16770	COG0745	RESPONSE REGULATOR receiver
HHL09_RS16785	COG4585	Histidine kinase
HHL09_RS16810	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HHL09_RS16820	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HHL09_RS16830	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HHL09_RS16835	COG0811	peptide transport
HHL09_RS16855	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HHL09_RS16870	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HHL09_RS16875	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HHL09_RS16885	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HHL09_RS16890	COG2264	protein methyltransferase activity
HHL09_RS16895	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HHL09_RS16905	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HHL09_RS16910	COG2890	protein-(glutamine-N5) methyltransferase activity
HHL09_RS16915	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HHL09_RS16940	COG0456	acetyltransferase
HHL09_RS16945	COG0284	orotidine-5'-phosphate decarboxylase activity
HHL09_RS16950	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HHL09_RS16995	COG0437	4 iron, 4 sulfur cluster binding
HHL09_RS17040	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HHL09_RS17050	COG1845	cytochrome c oxidase, subunit III
HHL09_RS17085	COG2311	Membrane
HHL09_RS17090	COG2514	catechol 2,3-dioxygenase activity
HHL09_RS17130	COG3275	phosphorelay sensor kinase activity
HHL09_RS17135	COG3279	Response regulator of the LytR AlgR family
HHL09_RS17155	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HHL09_RS17160	COG2755	lipolytic protein G-D-S-L family
HHL09_RS17170	COG2818	Glycosylase
HHL09_RS17185	COG0427	acetyl-CoA hydrolase
HHL09_RS17195	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HHL09_RS17215	COG1331	Highly conserved protein containing a thioredoxin domain
HHL09_RS17245	COG0514	ATP-dependent DNA helicase (RecQ)
HHL09_RS17270	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HHL09_RS17275	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HHL09_RS17320	COG0768	penicillin binding
HHL09_RS17325	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HHL09_RS17330	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HHL09_RS17335	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HHL09_RS17345	COG0791	NLP P60 protein
HHL09_RS17345	COG1388	LysM domain
HHL09_RS17350	COG0772	Belongs to the SEDS family
HHL09_RS17355	COG0354	folic acid binding
HHL09_RS17360	COG2084	Dehydrogenase
HHL09_RS17380	COG1215	transferase activity, transferring glycosyl groups
HHL09_RS17385	COG1376	ErfK ybiS ycfS ynhG family protein
HHL09_RS17390	COG0268	Binds directly to 16S ribosomal RNA
HHL09_RS17400	COG0072	phenylalanine-tRNA ligase activity
HHL09_RS17405	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HHL09_RS17410	COG3507	Belongs to the glycosyl hydrolase 43 family
HHL09_RS17420	COG0788	formyltetrahydrofolate deformylase activity
HHL09_RS17445	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HHL09_RS17450	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HHL09_RS17460	COG0737	Belongs to the 5'-nucleotidase family
HHL09_RS17465	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HHL09_RS17470	COG0248	Ppx GppA phosphatase
HHL09_RS17475	COG2326	polyphosphate kinase activity
HHL09_RS17495	COG0095	Lipoate-protein ligase
HHL09_RS17505	COG3119	arylsulfatase activity
HHL09_RS17515	COG3119	arylsulfatase activity
HHL09_RS17520	COG3119	arylsulfatase activity
HHL09_RS17595	COG1692	metallophosphoesterase
HHL09_RS17605	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HHL09_RS17625	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HHL09_RS17630	COG0081	regulation of translation
HHL09_RS17635	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HHL09_RS17640	COG0222	ribosome binding
HHL09_RS17645	COG0085	RNA polymerase activity
HHL09_RS17650	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HHL09_RS17655	COG2321	neutral zinc metallopeptidase
HHL09_RS17660	COG0673	inositol 2-dehydrogenase activity
HHL09_RS17675	COG3119	arylsulfatase activity
HHL09_RS17690	COG1573	uracil-dna glycosylase
HHL09_RS17695	COG0745	RESPONSE REGULATOR receiver
HHL09_RS17700	COG5002	protein histidine kinase activity
HHL09_RS17715	COG1363	Peptidase, m42
HHL09_RS17730	COG0551	DNA topoisomerase type I activity
HHL09_RS17730	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HHL09_RS17760	COG0758	DNA mediated transformation
HHL09_RS17775	COG0321	lipoyl(octanoyl) transferase activity
HHL09_RS17775	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HHL09_RS17780	COG0497	DNA recombination
HHL09_RS17790	COG0189	ligase activity
HHL09_RS17790	COG4067	protein conserved in archaea
HHL09_RS17795	COG0189	ligase activity
HHL09_RS17805	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HHL09_RS17810	COG0653	protein targeting
HHL09_RS17830	COG0848	biopolymer transport protein
HHL09_RS17855	COG0848	biopolymer transport protein
HHL09_RS17860	COG0811	peptide transport
HHL09_RS17930	COG1847	R3H domain protein
HHL09_RS17935	COG2259	Doxx family
HHL09_RS17970	COG0563	adenylate kinase activity
HHL09_RS17975	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HHL09_RS17985	COG0528	UMP kinase activity
HHL09_RS17990	COG0233	cytoplasmic translational termination
HHL09_RS18005	COG1131	(ABC) transporter
HHL09_RS18020	COG0708	Exodeoxyribonuclease III
HHL09_RS18025	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HHL09_RS18030	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HHL09_RS18050	COG0515	serine threonine protein kinase
HHL09_RS18050	COG2815	serine threonine protein kinase
HHL09_RS18135	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HHL09_RS18150	COG4206	TonB-dependent receptor
HHL09_RS18160	COG0038	chloride channel
HHL09_RS18185	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HHL09_RS18190	COG2208	phosphoserine phosphatase activity
HHL09_RS18195	COG0126	phosphoglycerate kinase activity
HHL09_RS18200	COG0149	triose-phosphate isomerase activity
HHL09_RS18225	COG3622	Belongs to the hyi family
HHL09_RS18255	COG5487	UPF0391 membrane protein
HHL09_RS18365	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HHL09_RS18380	COG0017	Asparaginyl-tRNA synthetase
HHL09_RS18395	COG0673	inositol 2-dehydrogenase activity
HHL09_RS18405	COG1696	Membrane protein involved in D-alanine export
HHL09_RS18410	COG1696	Membrane protein involved in D-alanine export
HHL09_RS18460	COG1404	Belongs to the peptidase S8 family
HHL09_RS18460	COG4935	Belongs to the peptidase S8 family
HHL09_RS18465	COG0537	adenosine 5'-monophosphoramidase activity
HHL09_RS18475	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HHL09_RS18510	COG1595	DNA-templated transcription, initiation
HHL09_RS18525	COG2197	response regulator
HHL09_RS18570	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HHL09_RS18580	COG0671	phosphoesterase, PA-phosphatase related
HHL09_RS18605	COG3869	Catalyzes the specific phosphorylation of arginine residues in
HHL09_RS18610	COG0542	response to heat
HHL09_RS18620	COG5002	protein histidine kinase activity
HHL09_RS18660	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HHL09_RS18660	COG4499	WXG100 protein secretion system (Wss), protein YukC
HHL09_RS18665	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HHL09_RS18670	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HHL09_RS18675	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HHL09_RS18680	COG3253	May function as heme-dependent peroxidase
HHL09_RS18725	COG1250	3-hydroxyacyl-CoA dehydrogenase
HHL09_RS18725	COG1024	Enoyl-CoA hydratase
HHL09_RS18730	COG0183	Belongs to the thiolase family
HHL09_RS18735	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
HHL09_RS18740	COG1752	Esterase of the alpha-beta hydrolase superfamily
HHL09_RS18755	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HHL09_RS18775	COG1393	Belongs to the ArsC family
HHL09_RS18785	COG2003	Belongs to the UPF0758 family
HHL09_RS18790	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HHL09_RS18795	COG0601	transmembrane transport
HHL09_RS18805	COG0601	transmembrane transport
HHL09_RS18810	COG4239	(ABC) transporter, permease
HHL09_RS18815	COG0747	negative chemotaxis
HHL09_RS18820	COG0444	Belongs to the ABC transporter superfamily
HHL09_RS18825	COG4608	Belongs to the ABC transporter superfamily
HHL09_RS18840	COG0151	Belongs to the GarS family
HHL09_RS18845	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HHL09_RS18855	COG0540	Belongs to the ATCase OTCase family
HHL09_RS18875	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HHL09_RS18895	COG2205	protein histidine kinase activity
HHL09_RS18900	COG0745	RESPONSE REGULATOR receiver
HHL09_RS18910	COG1028	Short-chain dehydrogenase reductase Sdr
HHL09_RS18915	COG1295	ribonuclease BN
HHL09_RS18950	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HHL09_RS18955	COG1187	pseudouridine synthase activity
HHL09_RS18965	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HHL09_RS19000	COG1082	Xylose isomerase domain protein TIM barrel
HHL09_RS19020	COG0673	inositol 2-dehydrogenase activity
HHL09_RS19030	COG0583	DNA-binding transcription factor activity
HHL09_RS19050	COG3119	arylsulfatase activity
HHL09_RS19090	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HHL09_RS19105	COG3876	Protein conserved in bacteria
HHL09_RS19130	COG0542	response to heat
HHL09_RS19145	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HHL09_RS19155	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HHL09_RS19160	COG0280	phosphate acetyltransferase
HHL09_RS19165	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HHL09_RS19170	COG2755	lipolytic protein G-D-S-L family
HHL09_RS19170	COG0657	acetylesterase activity
HHL09_RS19190	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HHL09_RS19195	COG4181	ATPase activity
HHL09_RS19215	COG0444	Belongs to the ABC transporter superfamily
HHL09_RS19245	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HHL09_RS19260	COG1252	NADH dehydrogenase
HHL09_RS19270	COG1472	Belongs to the glycosyl hydrolase 3 family
HHL09_RS19275	COG2819	hydrolase of the alpha beta superfamily
HHL09_RS19280	COG4774	siderophore transport
HHL09_RS19295	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HHL09_RS19300	COG1678	Uncharacterized ACR, COG1678
HHL09_RS19305	COG0477	Major facilitator Superfamily
HHL09_RS19315	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HHL09_RS19325	COG2166	iron-sulfur cluster assembly
HHL09_RS19330	COG2354	Protein conserved in bacteria
HHL09_RS19335	COG0861	Integral membrane protein TerC family
HHL09_RS19345	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HHL09_RS19350	COG0305	Participates in initiation and elongation during chromosome replication
HHL09_RS19350	COG0358	DNA primase activity
HHL09_RS19375	COG3279	Response regulator of the LytR AlgR family
HHL09_RS19380	COG3275	phosphorelay sensor kinase activity
HHL09_RS19385	COG1028	Short-chain dehydrogenase reductase Sdr
HHL09_RS19415	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HHL09_RS19445	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HHL09_RS19450	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HHL09_RS19455	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HHL09_RS19460	COG4974	Belongs to the 'phage' integrase family
HHL09_RS19475	COG2255	four-way junction helicase activity
HHL09_RS19480	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HHL09_RS19500	COG2378	regulation of single-species biofilm formation
HHL09_RS19545	COG0386	Belongs to the glutathione peroxidase family
HHL09_RS19590	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HHL09_RS19625	COG5000	phosphorelay sensor kinase activity
HHL09_RS19625	COG5002	protein histidine kinase activity
HHL09_RS19675	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HHL09_RS19710	COG1959	2 iron, 2 sulfur cluster binding
HHL09_RS19725	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HHL09_RS19730	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HHL09_RS19735	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HHL09_RS19740	COG4208	sulfate ABC transporter
HHL09_RS19770	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HHL09_RS19775	COG0129	dihydroxy-acid dehydratase activity
HHL09_RS19785	COG2824	Alkylphosphonate utilization operon protein PhnA
HHL09_RS19855	COG4941	Belongs to the sigma-70 factor family
HHL09_RS19900	COG3132	Protein of unknown function, DUF480
HHL09_RS19910	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HHL09_RS19925	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HHL09_RS19945	COG1017	nitric oxide dioxygenase activity
HHL09_RS19945	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HHL09_RS19970	COG3119	arylsulfatase activity
HHL09_RS20150	COG4974	Belongs to the 'phage' integrase family
HHL09_RS20170	COG2211	Major facilitator Superfamily
HHL09_RS20225	COG0642	Histidine kinase
HHL09_RS20230	COG0166	Belongs to the GPI family
HHL09_RS20250	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HHL09_RS20255	COG0181	hydroxymethylbilane synthase activity
HHL09_RS20265	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HHL09_RS20270	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HHL09_RS20290	COG2207	Transcriptional regulator
HHL09_RS20295	COG4221	oxidoreductase activity
HHL09_RS20300	COG1028	Short-chain dehydrogenase reductase Sdr
HHL09_RS20335	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HHL09_RS20350	COG0515	serine threonine protein kinase
HHL09_RS20410	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HHL09_RS20420	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HHL09_RS20425	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HHL09_RS20430	COG1561	YicC-like family, N-terminal region
HHL09_RS20435	COG0805	protein transport
HHL09_RS20440	COG1595	DNA-templated transcription, initiation
HHL09_RS20445	COG2304	oxidoreductase activity
HHL09_RS20460	COG0165	Argininosuccinate lyase
HHL09_RS20490	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HHL09_RS20495	COG0484	heat shock protein binding
HHL09_RS20500	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HHL09_RS20525	COG1272	protein, Hemolysin III
HHL09_RS20535	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HHL09_RS20550	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HHL09_RS20555	COG0516	GMP reductase activity
HHL09_RS20555	COG0517	IMP dehydrogenase activity
HHL09_RS20560	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HHL09_RS20560	COG0519	Catalyzes the synthesis of GMP from XMP
HHL09_RS20580	COG0583	DNA-binding transcription factor activity
HHL09_RS20585	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HHL09_RS20590	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HHL09_RS20615	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HHL09_RS20620	COG1610	YqeY-like protein
HHL09_RS20635	COG0038	chloride channel
HHL09_RS20645	COG0482	sulfurtransferase activity
HHL09_RS20690	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HHL09_RS20695	COG1131	(ABC) transporter
HHL09_RS20740	COG3008	intermembrane lipid transfer
HHL09_RS20740	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HHL09_RS20745	COG2995	paraquat-inducible protein a
HHL09_RS20750	COG2995	paraquat-inducible protein a
HHL09_RS20775	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HHL09_RS20805	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HHL09_RS20810	COG1185	polyribonucleotide nucleotidyltransferase activity
HHL09_RS20830	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HHL09_RS20830	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HHL09_RS20835	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HHL09_RS20840	COG2258	MOSC domain
HHL09_RS20850	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HHL09_RS20855	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HHL09_RS20860	COG0546	phosphoglycolate phosphatase activity
HHL09_RS20875	COG0673	inositol 2-dehydrogenase activity
HHL09_RS20885	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HHL09_RS20900	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HHL09_RS21000	COG0573	inorganic phosphate transmembrane transporter activity
HHL09_RS21005	COG0581	inorganic phosphate transmembrane transporter activity
HHL09_RS21010	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HHL09_RS21020	COG0693	protein deglycase activity
HHL09_RS21025	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HHL09_RS21035	COG0745	RESPONSE REGULATOR receiver
HHL09_RS21105	COG3850	Histidine kinase
HHL09_RS21110	COG2197	response regulator
HHL09_RS21160	COG0335	large ribosomal subunit rRNA binding
HHL09_RS21165	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HHL09_RS21180	COG4916	TIR domain
HHL09_RS21185	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HHL09_RS21190	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HHL09_RS21205	COG2211	Major facilitator Superfamily
HHL09_RS21230	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HHL09_RS21260	COG1028	Short-chain dehydrogenase reductase Sdr
HHL09_RS21265	COG2062	phosphohistidine phosphatase, SixA
HHL09_RS21290	COG1183	phosphatidylcholine synthase activity
HHL09_RS21300	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HHL09_RS21335	COG0110	maltose O-acetyltransferase activity
HHL09_RS21350	COG0346	lactoylglutathione lyase activity
HHL09_RS21360	COG3040	lipid binding
HHL09_RS21375	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
HHL09_RS21385	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HHL09_RS21395	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HHL09_RS21415	COG1131	(ABC) transporter
HHL09_RS21420	COG1702	phosphate starvation-inducible protein PhoH
HHL09_RS21425	COG1480	7TM receptor with intracellular HD hydrolase
HHL09_RS21430	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HHL09_RS21450	COG1166	arginine decarboxylase activity
HHL09_RS21465	COG0019	diaminopimelate decarboxylase activity
HHL09_RS21470	COG0039	L-malate dehydrogenase activity
HHL09_RS21475	COG1621	beta-fructofuranosidase activity
HHL09_RS21480	COG2815	serine threonine protein kinase
HHL09_RS21480	COG0515	serine threonine protein kinase
HHL09_RS21585	COG3119	arylsulfatase activity
HHL09_RS21595	COG0489	protein tyrosine kinase activity
HHL09_RS21600	COG0746	molybdenum cofactor guanylyltransferase activity
HHL09_RS21605	COG2267	carboxylic ester hydrolase activity
HHL09_RS21615	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HHL09_RS21625	COG0823	Involved in the tonB-independent uptake of proteins
HHL09_RS21650	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HHL09_RS21665	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
HHL09_RS21670	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HHL09_RS21675	COG0438	transferase activity, transferring glycosyl groups
HHL09_RS21680	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HHL09_RS21695	COG0525	valine-tRNA ligase activity
HHL09_RS21710	COG1490	D-aminoacyl-tRNA deacylase activity
HHL09_RS21750	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HHL09_RS21765	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HHL09_RS21765	COG1028	Short-chain dehydrogenase reductase Sdr
HHL09_RS21765	COG3321	synthase
HHL09_RS21765	COG0300	oxidoreductase activity
HHL09_RS21765	COG0318	PFAM AMP-dependent synthetase and ligase
HHL09_RS21780	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HHL09_RS21800	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HHL09_RS21835	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HHL09_RS21845	COG4771	TonB-dependent receptor
HHL09_RS21850	COG0523	cobalamin synthesis protein
HHL09_RS21860	COG3153	acetyltransferase
HHL09_RS21860	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HHL09_RS21880	COG0545	Peptidyl-prolyl cis-trans isomerase
HHL09_RS21900	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HHL09_RS21905	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HHL09_RS21915	COG0316	Belongs to the HesB IscA family
HHL09_RS21935	COG1040	competence protein
HHL09_RS21940	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HHL09_RS21955	COG0285	dihydrofolate synthase activity
HHL09_RS21965	COG1994	Peptidase M50
HHL09_RS21980	COG1793	dna ligase
HHL09_RS21980	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HHL09_RS21995	COG1028	Short-chain dehydrogenase reductase Sdr
HHL09_RS22000	COG2738	Putative neutral zinc metallopeptidase
HHL09_RS22010	COG1201	RNA secondary structure unwinding
HHL09_RS22030	COG0668	transmembrane transport
HHL09_RS22100	COG0148	phosphopyruvate hydratase activity
HHL09_RS22135	COG0012	GTP binding
HHL09_RS22165	COG2226	methyltransferase
HHL09_RS22170	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HHL09_RS22180	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HHL09_RS22215	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HHL09_RS22235	COG0436	Aminotransferase
HHL09_RS22250	COG2814	Major facilitator Superfamily
HHL09_RS22265	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HHL09_RS22275	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HHL09_RS22275	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HHL09_RS22300	COG2815	serine threonine protein kinase
HHL09_RS22300	COG0515	serine threonine protein kinase
HHL09_RS22320	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HHL09_RS22335	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HHL09_RS22345	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HHL09_RS22350	COG1053	succinate dehydrogenase
HHL09_RS22365	COG4608	Belongs to the ABC transporter superfamily
HHL09_RS22375	COG2308	Evidence 4 Homologs of previously reported genes of
HHL09_RS22385	COG1305	Transglutaminase-like
HHL09_RS22410	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HHL09_RS22430	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HHL09_RS22490	COG0587	DNA-directed DNA polymerase activity
HHL09_RS22500	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HHL09_RS22510	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HHL09_RS22520	COG3228	Belongs to the MtfA family
HHL09_RS22525	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HHL09_RS22545	COG0307	riboflavin synthase, alpha
HHL09_RS22580	COG1519	Transferase
HHL09_RS22585	COG0742	ribosomal rna small subunit methyltransferase
HHL09_RS22620	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HHL09_RS22625	COG0154	amidase activity
HHL09_RS22630	COG0359	binds to the 23S rRNA
HHL09_RS22635	COG0305	Participates in initiation and elongation during chromosome replication
HHL09_RS22650	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HHL09_RS22660	COG2022	thiamine diphosphate biosynthetic process
HHL09_RS22675	COG0039	L-malate dehydrogenase activity
HHL09_RS22685	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HHL09_RS22700	COG2010	Cytochrome c
HHL09_RS22700	COG4993	Dehydrogenase
HHL09_RS22725	COG2814	Major facilitator Superfamily
HHL09_RS22740	COG1609	Transcriptional regulator
HHL09_RS22750	COG0673	inositol 2-dehydrogenase activity
HHL09_RS22765	COG1131	(ABC) transporter
HHL09_RS22775	COG0508	dehydrogenase complex catalyzes the overall conversion of
HHL09_RS22800	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HHL09_RS22805	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HHL09_RS22810	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HHL09_RS22815	COG1459	type II secretion system
HHL09_RS22820	COG2165	general secretion pathway protein
HHL09_RS22835	COG0215	cysteine-tRNA ligase activity
HHL09_RS22845	COG0113	porphobilinogen synthase activity
HHL09_RS22855	COG3254	rhamnose metabolic process
HHL09_RS22875	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HHL09_RS22875	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HHL09_RS22885	COG0673	inositol 2-dehydrogenase activity
HHL09_RS22890	COG0673	inositol 2-dehydrogenase activity
HHL09_RS22925	COG0628	permease
HHL09_RS22930	COG1612	heme a metabolic process
HHL09_RS22935	COG0686	Belongs to the AlaDH PNT family
HHL09_RS22960	COG2197	response regulator
HHL09_RS22965	COG4585	Histidine kinase
HHL09_RS22975	COG3119	arylsulfatase activity
HHL09_RS22975	COG3408	Glycogen debranching enzyme
HHL09_RS23020	COG2197	response regulator
HHL09_RS23025	COG2423	ornithine cyclodeaminase activity
HHL09_RS23030	COG3842	ATPase activity
HHL09_RS23035	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HHL09_RS23085	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HHL09_RS23120	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HHL09_RS23130	COG3250	beta-galactosidase activity
HHL09_RS23135	COG0288	reversible hydration of carbon dioxide
HHL09_RS23145	COG2755	lipolytic protein G-D-S-L family
HHL09_RS23165	COG0437	4 iron, 4 sulfur cluster binding
HHL09_RS23170	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HHL09_RS23175	COG1116	anion transmembrane transporter activity
HHL09_RS23180	COG1116	anion transmembrane transporter activity
HHL09_RS23185	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HHL09_RS23190	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HHL09_RS23200	COG2223	nitrite transmembrane transporter activity
HHL09_RS23205	COG2815	serine threonine protein kinase
HHL09_RS23205	COG0515	serine threonine protein kinase
HHL09_RS23210	COG2223	nitrite transmembrane transporter activity
HHL09_RS23215	COG1116	anion transmembrane transporter activity
HHL09_RS23215	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HHL09_RS23220	COG0583	DNA-binding transcription factor activity
HHL09_RS23240	COG2207	Transcriptional regulator
HHL09_RS23240	COG1609	Transcriptional regulator
HHL09_RS23255	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HHL09_RS23260	COG0131	Imidazoleglycerol-phosphate dehydratase
HHL09_RS23290	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HHL09_RS23290	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HHL09_RS23295	COG1051	belongs to the nudix hydrolase family
HHL09_RS23330	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HHL09_RS23335	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HHL09_RS23345	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HHL09_RS23405	COG0793	Belongs to the peptidase S41A family
HHL09_RS23430	COG1295	ribonuclease BN
HHL09_RS23430	COG1959	2 iron, 2 sulfur cluster binding
HHL09_RS23440	COG1082	Xylose isomerase domain protein TIM barrel
HHL09_RS23465	COG0659	secondary active sulfate transmembrane transporter activity
HHL09_RS23485	COG0583	DNA-binding transcription factor activity
HHL09_RS23490	COG0488	(ABC) transporter
HHL09_RS23495	COG0515	serine threonine protein kinase
HHL09_RS23495	COG2815	serine threonine protein kinase
HHL09_RS23510	COG1309	transcriptional regulator
HHL09_RS23515	COG1028	Short-chain dehydrogenase reductase Sdr
HHL09_RS23545	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HHL09_RS23555	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HHL09_RS23560	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HHL09_RS23570	COG2943	transferase activity, transferring hexosyl groups
HHL09_RS23580	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
HHL09_RS23585	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HHL09_RS23620	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HHL09_RS23625	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HHL09_RS23630	COG0175	sulfate reduction
HHL09_RS23680	COG1136	(ABC) transporter
HHL09_RS23685	COG0167	dihydroorotate dehydrogenase activity
HHL09_RS23705	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HHL09_RS23710	COG1819	glycosyl
HHL09_RS23715	COG5002	protein histidine kinase activity
HHL09_RS23725	COG1136	(ABC) transporter
HHL09_RS23725	COG0577	efflux transmembrane transporter activity
HHL09_RS23730	COG0577	efflux transmembrane transporter activity
HHL09_RS23730	COG1136	(ABC) transporter
HHL09_RS23745	COG1595	DNA-templated transcription, initiation
HHL09_RS23780	COG0657	acetylesterase activity
HHL09_RS23780	COG2755	lipolytic protein G-D-S-L family
HHL09_RS23815	COG0653	protein targeting
HHL09_RS23825	COG1028	Short-chain dehydrogenase reductase Sdr
HHL09_RS23835	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HHL09_RS23840	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HHL09_RS23845	COG1121	(ABC) transporter
HHL09_RS23875	COG2197	response regulator
HHL09_RS23880	COG3851	Histidine kinase
HHL09_RS23885	COG3401	FG-GAP repeat protein
HHL09_RS23930	COG4585	Histidine kinase
HHL09_RS23935	COG2197	response regulator
HHL09_RS23965	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
HHL09_RS23980	COG2197	response regulator
HHL09_RS23985	COG4585	Histidine kinase
HHL09_RS24010	COG0823	Involved in the tonB-independent uptake of proteins
HHL09_RS24020	COG2755	lipolytic protein G-D-S-L family
HHL09_RS24020	COG0657	acetylesterase activity
HHL09_RS24050	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HHL09_RS24055	COG0135	phosphoribosylanthranilate isomerase activity
HHL09_RS24080	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HHL09_RS24085	COG0765	amino acid transport
HHL09_RS24090	COG1126	abc transporter atp-binding protein
HHL09_RS24115	COG1176	ABC-type spermidine putrescine transport system, permease component I
HHL09_RS24120	COG1176	ABC-type spermidine putrescine transport system, permease component I
HHL09_RS24125	COG3842	ATPase activity
HHL09_RS24140	COG2226	methyltransferase
HHL09_RS24145	COG2205	protein histidine kinase activity
HHL09_RS24145	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HHL09_RS24145	COG0784	Response regulator, receiver
HHL09_RS24145	COG2198	Histidine kinase
HHL09_RS24150	COG1494	fructose-1,6-bisphosphatase
HHL09_RS24155	COG1070	Carbohydrate kinase
HHL09_RS24160	COG1349	DNA-binding transcription factor activity
HHL09_RS24165	COG1028	Short-chain dehydrogenase reductase Sdr
HHL09_RS24165	COG3347	Dehydrogenase
HHL09_RS24195	COG1131	(ABC) transporter
HHL09_RS24205	COG0714	Associated with various cellular activities
HHL09_RS24210	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HHL09_RS24225	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HHL09_RS24225	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HHL09_RS24235	COG1007	ATP synthesis coupled electron transport
HHL09_RS24240	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HHL09_RS24245	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HHL09_RS24250	COG0713	ATP synthesis coupled electron transport
HHL09_RS24265	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HHL09_RS24270	COG1034	ATP synthesis coupled electron transport
HHL09_RS24275	COG1216	Glycosyl transferase, family 2
HHL09_RS24295	COG2205	protein histidine kinase activity
HHL09_RS24295	COG0784	Response regulator, receiver
HHL09_RS24305	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HHL09_RS24310	COG4999	Histidine kinase
HHL09_RS24310	COG2205	protein histidine kinase activity
HHL09_RS24310	COG3850	Histidine kinase
HHL09_RS24310	COG3437	response regulator, receiver
HHL09_RS24350	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HHL09_RS24370	COG1506	peptidase
HHL09_RS24420	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HHL09_RS24475	COG1082	Xylose isomerase domain protein TIM barrel
HHL09_RS24480	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HHL09_RS24510	COG0745	RESPONSE REGULATOR receiver
HHL09_RS24515	COG2205	protein histidine kinase activity
HHL09_RS24530	COG4566	intracellular signal transduction
HHL09_RS24550	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HHL09_RS24560	COG3119	arylsulfatase activity
HHL09_RS24565	COG3119	arylsulfatase activity
HHL09_RS24580	COG3119	arylsulfatase activity
HHL09_RS24610	COG3119	arylsulfatase activity
HHL09_RS24620	COG3119	arylsulfatase activity
HHL09_RS24635	COG0714	Associated with various cellular activities
HHL09_RS24655	COG2304	oxidoreductase activity
HHL09_RS24695	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HHL09_RS24700	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HHL09_RS24720	COG1054	Belongs to the UPF0176 family
HHL09_RS24735	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HHL09_RS24740	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HHL09_RS24745	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HHL09_RS24750	COG0583	DNA-binding transcription factor activity
HHL09_RS24800	COG2239	Acts as a magnesium transporter
HHL09_RS24805	COG1509	lysine 2,3-aminomutase activity
HHL09_RS24815	COG1595	DNA-templated transcription, initiation
HHL09_RS24830	COG4941	Belongs to the sigma-70 factor family
HHL09_RS24835	COG3795	YCII-related domain
HHL09_RS24840	COG1530	ribonuclease E activity
HHL09_RS24845	COG0768	penicillin binding
HHL09_RS24860	COG1077	Cell shape determining protein MreB Mrl
HHL09_RS24865	COG1192	Involved in chromosome partitioning
HHL09_RS24875	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HHL09_RS25005	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HHL09_RS25020	COG0456	acetyltransferase
HHL09_RS25065	COG0513	Belongs to the DEAD box helicase family
HHL09_RS25080	COG0300	oxidoreductase activity
HHL09_RS25090	COG0768	penicillin binding
HHL09_RS25110	COG1404	Belongs to the peptidase S8 family
HHL09_RS25135	COG1696	Membrane protein involved in D-alanine export
HHL09_RS25175	COG4566	intracellular signal transduction
HHL09_RS25180	COG4191	Histidine kinase
HHL09_RS25190	COG1131	(ABC) transporter
HHL09_RS25195	COG0584	glycerophosphoryl diester phosphodiesterase
HHL09_RS25240	COG0537	adenosine 5'-monophosphoramidase activity
HHL09_RS25260	COG0501	Belongs to the peptidase M48B family
HHL09_RS25265	COG0667	Aldo Keto reductase
HHL09_RS25280	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HHL09_RS25280	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HHL09_RS25290	COG0432	Pfam Uncharacterised protein family UPF0047
HHL09_RS25310	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HHL09_RS25315	COG1643	Atp-dependent helicase
HHL09_RS25360	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HHL09_RS25365	COG0504	CTP synthase activity
HHL09_RS25390	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HHL09_RS25455	COG1073	alpha beta
HHL09_RS25460	COG2340	Cysteine-rich secretory protein family
HHL09_RS25470	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HHL09_RS25475	COG0067	glutamate synthase
HHL09_RS25475	COG0069	glutamate synthase activity
HHL09_RS25475	COG0070	glutamate synthase
HHL09_RS25490	COG4316	Uncharacterized protein conserved in bacteria (DUF2251)
HHL09_RS25495	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HHL09_RS25500	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HHL09_RS25510	COG1522	sequence-specific DNA binding
HHL09_RS25515	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HHL09_RS25535	COG0205	6-phosphofructokinase activity
HHL09_RS25550	COG0724	RNA recognition motif
HHL09_RS25565	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HHL09_RS25580	COG0515	serine threonine protein kinase
HHL09_RS25580	COG2815	serine threonine protein kinase
HHL09_RS25600	COG0513	Belongs to the DEAD box helicase family
HHL09_RS25625	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HHL09_RS25635	COG0321	lipoyl(octanoyl) transferase activity
HHL09_RS25655	COG0217	transcriptional regulatory protein
HHL09_RS25665	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HHL09_RS25665	COG2010	Cytochrome c
HHL09_RS25695	COG1028	Short-chain dehydrogenase reductase Sdr
HHL09_RS25720	COG0515	serine threonine protein kinase
HHL09_RS25720	COG2815	serine threonine protein kinase
HHL09_RS25730	COG0564	pseudouridine synthase activity
HHL09_RS25750	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HHL09_RS25800	COG0018	arginyl-trna synthetase
HHL09_RS25805	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HHL09_RS25805	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HHL09_RS25805	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HHL09_RS25820	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HHL09_RS25840	COG0393	Putative heavy-metal-binding
HHL09_RS25855	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HHL09_RS25875	COG3550	peptidyl-serine autophosphorylation
HHL09_RS25880	COG0714	Associated with various cellular activities
HHL09_RS25910	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HHL09_RS25925	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HHL09_RS25930	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HHL09_RS25935	COG0586	Pfam SNARE associated Golgi protein
HHL09_RS25945	COG1640	4-alpha-glucanotransferase
HHL09_RS25970	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HHL09_RS25980	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HHL09_RS25995	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HHL09_RS26015	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HHL09_RS26275	COG2003	Belongs to the UPF0758 family