locus-tag	class	description
EYE35_RS00055	COG1262	PFAM Formylglycine-generating sulfatase enzyme
EYE35_RS00060	COG3119	arylsulfatase activity
EYE35_RS00070	COG1120	ATPase activity
EYE35_RS00085	COG4774	siderophore transport
EYE35_RS00090	COG1940	carbohydrate kinase activity
EYE35_RS00100	COG1175	transmembrane transport
EYE35_RS00105	COG0395	ABC-type sugar transport system, permease component
EYE35_RS00115	COG2971	BadF BadG BcrA BcrD
EYE35_RS00135	COG1349	DNA-binding transcription factor activity
EYE35_RS00150	COG0601	transmembrane transport
EYE35_RS00165	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EYE35_RS00205	COG1519	Transferase
EYE35_RS00210	COG1663	tetraacyldisaccharide 4'-kinase activity
EYE35_RS00230	COG1194	a g-specific adenine glycosylase
EYE35_RS00270	COG0019	diaminopimelate decarboxylase activity
EYE35_RS00290	COG4172	Belongs to the ABC transporter superfamily
EYE35_RS00295	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EYE35_RS00300	COG0601	transmembrane transport
EYE35_RS00305	COG4166	transmembrane transport
EYE35_RS00325	COG1309	transcriptional regulator
EYE35_RS00330	COG5507	3-demethylubiquinone-9 3-methyltransferase
EYE35_RS00340	COG3118	belongs to the thioredoxin family
EYE35_RS00355	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EYE35_RS00360	COG0154	amidase activity
EYE35_RS00365	COG0436	Aminotransferase
EYE35_RS00370	COG1674	ftsk spoiiie
EYE35_RS00390	COG0405	Gamma-glutamyltransferase
EYE35_RS00400	COG1366	Belongs to the anti-sigma-factor antagonist family
EYE35_RS00405	COG1956	GAF domain-containing protein
EYE35_RS00420	COG0564	pseudouridine synthase activity
EYE35_RS00470	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
EYE35_RS00490	COG0133	tryptophan synthase activity
EYE35_RS00505	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
EYE35_RS00515	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
EYE35_RS00520	COG1999	signal sequence binding
EYE35_RS00525	COG2205	protein histidine kinase activity
EYE35_RS00530	COG2205	protein histidine kinase activity
EYE35_RS00540	COG3178	'Phosphotransferase
EYE35_RS00545	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
EYE35_RS00550	COG2887	Belongs to the helicase family. UvrD subfamily
EYE35_RS00555	COG1074	ATP-dependent DNA helicase activity
EYE35_RS00570	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
EYE35_RS00580	COG1696	Membrane protein involved in D-alanine export
EYE35_RS00610	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
EYE35_RS00615	COG0463	Glycosyl transferase, family 2
EYE35_RS00625	COG0577	efflux transmembrane transporter activity
EYE35_RS00630	COG1136	(ABC) transporter
EYE35_RS00680	COG1414	Transcriptional regulator
EYE35_RS00690	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
EYE35_RS00695	COG3257	ureidoglycine aminohydrolase activity
EYE35_RS00705	COG2351	hydroxyisourate hydrolase activity
EYE35_RS00720	COG0538	isocitrate dehydrogenase activity
EYE35_RS00725	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
EYE35_RS00730	COG0318	PFAM AMP-dependent synthetase and ligase
EYE35_RS00735	COG0179	Fumarylacetoacetate (FAA) hydrolase
EYE35_RS00740	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EYE35_RS00745	COG0628	permease
EYE35_RS00765	COG0174	glutamine synthetase
EYE35_RS00770	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EYE35_RS00775	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
EYE35_RS00800	COG3038	cytochrome b561
EYE35_RS00805	COG0529	Catalyzes the synthesis of activated sulfate
EYE35_RS00805	COG2046	Belongs to the sulfate adenylyltransferase family
EYE35_RS00810	COG0492	ferredoxin-NADP+ reductase activity
EYE35_RS00815	COG1522	sequence-specific DNA binding
EYE35_RS00820	COG1496	oxidoreductase activity
EYE35_RS00830	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
EYE35_RS00845	COG0745	RESPONSE REGULATOR receiver
EYE35_RS00850	COG0643	Histidine kinase
EYE35_RS00850	COG2198	Histidine kinase
EYE35_RS00855	COG0835	chemotaxis
EYE35_RS00860	COG0835	chemotaxis
EYE35_RS00870	COG2201	protein-glutamate methylesterase activity
EYE35_RS00880	COG0435	Glutathione S-transferase
EYE35_RS00885	COG2204	response regulator
EYE35_RS00900	COG0280	phosphate acetyltransferase
EYE35_RS00900	COG0281	malic enzyme
EYE35_RS00905	COG0295	cytidine deaminase activity
EYE35_RS00910	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
EYE35_RS00915	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
EYE35_RS00920	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
EYE35_RS00925	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
EYE35_RS00955	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
EYE35_RS00965	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
EYE35_RS00970	COG2186	Transcriptional regulator
EYE35_RS00975	COG1802	Transcriptional regulator
EYE35_RS00980	COG1063	alcohol dehydrogenase
EYE35_RS00985	COG0246	Mannitol dehydrogenase
EYE35_RS00990	COG2721	sulfolactate sulfo-lyase activity
EYE35_RS00995	COG4191	Histidine kinase
EYE35_RS01000	COG2204	response regulator
EYE35_RS01005	COG2358	TRAP transporter, solute receptor (TAXI family
EYE35_RS01190	COG3728	DNA packaging
EYE35_RS01190	COG5484	DNA packaging
EYE35_RS01300	COG3723	Recombinational DNA repair protein, rece pathway
EYE35_RS01330	COG3750	Belongs to the UPF0335 family
EYE35_RS01385	COG3920	Histidine kinase
EYE35_RS01390	COG0784	Response regulator, receiver
EYE35_RS01560	COG3750	Belongs to the UPF0335 family
EYE35_RS01585	COG1609	Transcriptional regulator
EYE35_RS01600	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
EYE35_RS01610	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
EYE35_RS01620	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EYE35_RS01640	COG0681	Belongs to the peptidase S26 family
EYE35_RS01650	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
EYE35_RS01675	COG0745	RESPONSE REGULATOR receiver
EYE35_RS01680	COG2205	protein histidine kinase activity
EYE35_RS01700	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EYE35_RS01710	COG1250	3-hydroxyacyl-CoA dehydrogenase
EYE35_RS01730	COG2096	Adenosyltransferase
EYE35_RS01740	COG0300	oxidoreductase activity
EYE35_RS01750	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
EYE35_RS01795	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
EYE35_RS01815	COG0697	spore germination
EYE35_RS01845	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
EYE35_RS01860	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
EYE35_RS01885	COG0255	Belongs to the universal ribosomal protein uL29 family
EYE35_RS01945	COG0201	protein transport
EYE35_RS01950	COG0563	adenylate kinase activity
EYE35_RS01980	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EYE35_RS01985	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
EYE35_RS01995	COG0564	pseudouridine synthase activity
EYE35_RS02005	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EYE35_RS02010	COG4597	amino acid ABC transporter
EYE35_RS02015	COG0765	amino acid transport
EYE35_RS02020	COG1126	abc transporter atp-binding protein
EYE35_RS02060	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EYE35_RS02075	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EYE35_RS02075	COG0072	phenylalanine-tRNA ligase activity
EYE35_RS02105	COG0469	pyruvate kinase activity
EYE35_RS02120	COG4948	Mandelate Racemase Muconate Lactonizing
EYE35_RS02155	COG2133	pyrroloquinoline quinone binding
EYE35_RS02220	COG1609	Transcriptional regulator
EYE35_RS02225	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
EYE35_RS02225	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
EYE35_RS02230	COG1105	Belongs to the carbohydrate kinase PfkB family
EYE35_RS02235	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EYE35_RS02235	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EYE35_RS02245	COG0789	Transcriptional regulator
EYE35_RS02250	COG2217	Heavy metal translocating P-type atpase
EYE35_RS02255	COG0629	single-stranded DNA binding
EYE35_RS02260	COG0741	lytic transglycosylase activity
EYE35_RS02265	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
EYE35_RS02270	COG2032	superoxide dismutase activity
EYE35_RS02275	COG1862	Preprotein translocase
EYE35_RS02280	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EYE35_RS02285	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EYE35_RS02290	COG3737	Protein of unknown function (DUF498/DUF598)
EYE35_RS02295	COG4133	protoheme IX ABC transporter activity
EYE35_RS02300	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EYE35_RS02305	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EYE35_RS02315	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EYE35_RS02320	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
EYE35_RS02335	COG0180	Tryptophanyl-tRNA synthetase
EYE35_RS02345	COG0728	peptidoglycan biosynthetic process
EYE35_RS02350	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
EYE35_RS02360	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
EYE35_RS02370	COG0189	ligase activity
EYE35_RS02375	COG0606	chelatase, subunit chli
EYE35_RS02385	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
EYE35_RS02390	COG1918	ferrous iron import across plasma membrane
EYE35_RS02400	COG3685	Protein conserved in bacteria
EYE35_RS02405	COG0243	molybdopterin cofactor binding
EYE35_RS02410	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
EYE35_RS02415	COG0521	Mo-molybdopterin cofactor biosynthetic process
EYE35_RS02425	COG0312	modulator of DNA gyrase
EYE35_RS02465	COG0612	Peptidase, M16
EYE35_RS02490	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
EYE35_RS02510	COG2917	probably involved in intracellular septation
EYE35_RS02520	COG0552	protein localization to endoplasmic reticulum
EYE35_RS02540	COG0151	Belongs to the GarS family
EYE35_RS02545	COG0469	pyruvate kinase activity
EYE35_RS02550	COG0527	aspartate kinase activity
EYE35_RS02570	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EYE35_RS02575	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EYE35_RS02585	COG0752	glycyl-tRNA synthetase alpha subunit
EYE35_RS02595	COG0751	glycine-tRNA ligase activity
EYE35_RS02600	COG0574	Belongs to the PEP-utilizing enzyme family
EYE35_RS02600	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
EYE35_RS02610	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
EYE35_RS02640	COG1522	sequence-specific DNA binding
EYE35_RS02665	COG1802	Transcriptional regulator
EYE35_RS02680	COG0505	Belongs to the CarA family
EYE35_RS02685	COG1610	YqeY-like protein
EYE35_RS02715	COG3842	ATPase activity
EYE35_RS02725	COG1176	ABC-type spermidine putrescine transport system, permease component I
EYE35_RS02730	COG1177	transmembrane transport
EYE35_RS02745	COG0670	Belongs to the BI1 family
EYE35_RS02755	COG0583	DNA-binding transcription factor activity
EYE35_RS02760	COG3321	synthase
EYE35_RS02760	COG0604	alcohol dehydrogenase
EYE35_RS02760	COG1028	Short-chain dehydrogenase reductase Sdr
EYE35_RS02775	COG3773	Cell wall hydrolase
EYE35_RS02780	COG0668	transmembrane transport
EYE35_RS02785	COG0402	S-adenosylhomocysteine deaminase activity
EYE35_RS02790	COG2239	Acts as a magnesium transporter
EYE35_RS02795	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
EYE35_RS02845	COG4964	Belongs to the GSP D family
EYE35_RS02865	COG0741	lytic transglycosylase activity
EYE35_RS02890	COG0583	DNA-binding transcription factor activity
EYE35_RS02950	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
EYE35_RS02955	COG2258	MOSC domain
EYE35_RS02970	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
EYE35_RS02975	COG1268	BioY protein
EYE35_RS02985	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EYE35_RS02990	COG0730	response to heat
EYE35_RS02995	COG0305	Participates in initiation and elongation during chromosome replication
EYE35_RS03005	COG0418	dihydroorotase activity
EYE35_RS03010	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
EYE35_RS03030	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
EYE35_RS03040	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
EYE35_RS03060	COG0175	sulfate reduction
EYE35_RS03065	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EYE35_RS03075	COG1648	precorrin-2 dehydrogenase activity
EYE35_RS03075	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EYE35_RS03080	COG1522	sequence-specific DNA binding
EYE35_RS03090	COG0149	triose-phosphate isomerase activity
EYE35_RS03100	COG2151	metal-sulfur cluster biosynthetic enzyme
EYE35_RS03235	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
EYE35_RS03245	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EYE35_RS03260	COG3119	arylsulfatase activity
EYE35_RS03265	COG0657	acetylesterase activity
EYE35_RS03270	COG1278	Cold shock
EYE35_RS03295	COG0488	(ABC) transporter
EYE35_RS03305	COG1764	response to oxidative stress
EYE35_RS03310	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
EYE35_RS03330	COG0659	secondary active sulfate transmembrane transporter activity
EYE35_RS03340	COG0563	adenylate kinase activity
EYE35_RS03350	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EYE35_RS03355	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
EYE35_RS03365	COG0745	RESPONSE REGULATOR receiver
EYE35_RS03370	COG2176	DNA-directed DNA polymerase activity
EYE35_RS03370	COG5002	protein histidine kinase activity
EYE35_RS03380	COG3106	COG3106 Predicted ATPase
EYE35_RS03385	COG3768	UPF0283 membrane protein
EYE35_RS03390	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
EYE35_RS03400	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EYE35_RS03410	COG1183	phosphatidylcholine synthase activity
EYE35_RS03420	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
EYE35_RS03440	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EYE35_RS03470	COG0501	Belongs to the peptidase M48B family
EYE35_RS03480	COG2076	Multidrug Resistance protein
EYE35_RS03495	COG1686	Belongs to the peptidase S11 family
EYE35_RS03520	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
EYE35_RS03550	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
EYE35_RS03555	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
EYE35_RS03630	COG1272	protein, Hemolysin III
EYE35_RS03640	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
EYE35_RS03645	COG0673	inositol 2-dehydrogenase activity
EYE35_RS03650	COG1063	alcohol dehydrogenase
EYE35_RS03660	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EYE35_RS03685	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EYE35_RS03700	COG2197	response regulator
EYE35_RS03785	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
EYE35_RS03815	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EYE35_RS03820	COG1802	Transcriptional regulator
EYE35_RS03825	COG1904	glucuronate isomerase
EYE35_RS03830	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
EYE35_RS03845	COG1917	Cupin 2, conserved barrel domain protein
EYE35_RS03855	COG1028	Short-chain dehydrogenase reductase Sdr
EYE35_RS03860	COG0246	Mannitol dehydrogenase
EYE35_RS03870	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
EYE35_RS03880	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
EYE35_RS03885	COG0235	Class ii aldolase
EYE35_RS03895	COG3909	cytochrome
EYE35_RS03900	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EYE35_RS03920	COG0579	oxidoreductase
EYE35_RS03930	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
EYE35_RS03940	COG0826	peptidase U32
EYE35_RS03945	COG0826	peptidase U32
EYE35_RS03950	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
EYE35_RS03980	COG5642	Protein of unknown function (DUF2384)
EYE35_RS03995	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EYE35_RS03995	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
EYE35_RS04015	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EYE35_RS04025	COG0121	glutamine amidotransferase
EYE35_RS04030	COG1217	gtp-binding protein TYPA
EYE35_RS04045	COG0538	isocitrate dehydrogenase activity
EYE35_RS04055	COG2945	thiolester hydrolase activity
EYE35_RS04070	COG0719	Fe-S assembly protein
EYE35_RS04080	COG0396	ATPase activity
EYE35_RS04085	COG0719	Fe-S assembly protein
EYE35_RS04100	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EYE35_RS04105	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
EYE35_RS04120	COG3901	Regulator of nitric oxide reductase transcription
EYE35_RS04120	COG0348	domain, Protein
EYE35_RS04135	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EYE35_RS04145	COG0667	Aldo Keto reductase
EYE35_RS04195	COG3706	GGDEF domain
EYE35_RS04205	COG0546	phosphoglycolate phosphatase activity
EYE35_RS04210	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
EYE35_RS04220	COG5002	protein histidine kinase activity
EYE35_RS04220	COG5001	Diguanylate cyclase
EYE35_RS04220	COG3447	MASE1 domain protein
EYE35_RS04235	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EYE35_RS04240	COG3706	GGDEF domain
EYE35_RS04250	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
EYE35_RS04290	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
EYE35_RS04295	COG0358	DNA primase activity
EYE35_RS04300	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EYE35_RS04315	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EYE35_RS04315	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EYE35_RS04325	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
EYE35_RS04345	COG1278	Cold shock
EYE35_RS04365	COG3243	poly(R)-hydroxyalkanoic acid synthase
EYE35_RS04380	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EYE35_RS04385	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EYE35_RS04390	COG0174	glutamine synthetase
EYE35_RS04395	COG0518	GMP synthase (glutamine-hydrolyzing) activity
EYE35_RS04395	COG0519	Catalyzes the synthesis of GMP from XMP
EYE35_RS04400	COG0174	glutamine synthetase
EYE35_RS04405	COG4160	amino acid transport
EYE35_RS04470	COG0697	spore germination
EYE35_RS04475	COG1760	l-serine dehydratase
EYE35_RS04495	COG0330	HflC and HflK could
EYE35_RS04500	COG0330	HflC and HflK could
EYE35_RS04515	COG0587	DNA-directed DNA polymerase activity
EYE35_RS04535	COG3842	ATPase activity
EYE35_RS04560	COG3845	ABC transporter
EYE35_RS04565	COG4603	Belongs to the binding-protein-dependent transport system permease family
EYE35_RS04570	COG1079	Belongs to the binding-protein-dependent transport system permease family
EYE35_RS04575	COG0402	S-adenosylhomocysteine deaminase activity
EYE35_RS04585	COG2264	protein methyltransferase activity
EYE35_RS04595	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
EYE35_RS04655	COG2010	Cytochrome c
EYE35_RS04660	COG3256	nitric oxide reductase
EYE35_RS04665	COG0714	Associated with various cellular activities
EYE35_RS04690	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EYE35_RS04695	COG2197	response regulator
EYE35_RS04700	COG2814	Major facilitator Superfamily
EYE35_RS04730	COG0829	nickel cation binding
EYE35_RS04755	COG0804	urea catabolic process
EYE35_RS04765	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
EYE35_RS04790	COG1172	Belongs to the binding-protein-dependent transport system permease family
EYE35_RS04805	COG3474	cytochrome
EYE35_RS04815	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
EYE35_RS04855	COG1429	ligase activity, forming nitrogen-metal bonds
EYE35_RS04865	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
EYE35_RS04885	COG1032	radical SAM domain protein
EYE35_RS04890	COG1719	4-vinyl reductase, 4VR
EYE35_RS04895	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
EYE35_RS04900	COG2211	Major facilitator Superfamily
EYE35_RS04905	COG0644	oxidoreductase
EYE35_RS04920	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
EYE35_RS04925	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
EYE35_RS04935	COG1233	COG1233 Phytoene dehydrogenase and related
EYE35_RS04940	COG1562	ergosterol biosynthetic process
EYE35_RS04950	COG5621	secreted hydrolase
EYE35_RS04955	COG1233	COG1233 Phytoene dehydrogenase and related
EYE35_RS04960	COG0142	geranyltranstransferase activity
EYE35_RS04965	COG0500	methyltransferase
EYE35_RS04970	COG1063	alcohol dehydrogenase
EYE35_RS04975	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
EYE35_RS04980	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
EYE35_RS04985	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
EYE35_RS05025	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
EYE35_RS05030	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EYE35_RS05035	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
EYE35_RS05055	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EYE35_RS05060	COG0354	folic acid binding
EYE35_RS05070	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
EYE35_RS05080	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
EYE35_RS05085	COG1376	ErfK ybiS ycfS ynhG family protein
EYE35_RS05105	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
EYE35_RS05125	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
EYE35_RS05135	COG0840	transmembrane signaling receptor activity
EYE35_RS05260	COG1061	Type III restriction enzyme res subunit
EYE35_RS05305	COG1475	DNA binding
EYE35_RS05460	COG3034	peptidoglycan biosynthetic process
EYE35_RS05470	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
EYE35_RS05490	COG1999	signal sequence binding
EYE35_RS05500	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
EYE35_RS05500	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EYE35_RS05510	COG1999	signal sequence binding
EYE35_RS05515	COG0789	Transcriptional regulator
EYE35_RS05535	COG1061	Type III restriction enzyme res subunit
EYE35_RS05550	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EYE35_RS05555	COG3547	Transposase (IS116 IS110 IS902 family)
EYE35_RS05595	COG3152	Membrane
EYE35_RS05650	COG3609	addiction module antidote protein, CC2985 family
EYE35_RS05685	COG2340	Cysteine-rich secretory protein family
EYE35_RS05690	COG4136	ATPase activity
EYE35_RS05695	COG4135	transport system, permease component
EYE35_RS05740	COG0439	Biotin carboxylase
EYE35_RS05765	COG1309	transcriptional regulator
EYE35_RS05770	COG1309	transcriptional regulator
EYE35_RS05790	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EYE35_RS05795	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EYE35_RS05800	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EYE35_RS05805	COG0277	FAD linked oxidase domain protein
EYE35_RS05810	COG0129	dihydroxy-acid dehydratase activity
EYE35_RS05815	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EYE35_RS05820	COG1028	Short-chain dehydrogenase reductase Sdr
EYE35_RS05825	COG0179	Fumarylacetoacetate (FAA) hydrolase
EYE35_RS05830	COG3800	Transcriptional regulator
EYE35_RS05830	COG1396	sequence-specific DNA binding
EYE35_RS05835	COG0745	RESPONSE REGULATOR receiver
EYE35_RS05875	COG3750	Belongs to the UPF0335 family
EYE35_RS05900	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EYE35_RS05950	COG2205	protein histidine kinase activity
EYE35_RS05955	COG0784	Response regulator, receiver
EYE35_RS05960	COG3920	Histidine kinase
EYE35_RS05980	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
EYE35_RS05980	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
EYE35_RS06035	COG1757	Na H antiporter
EYE35_RS06040	COG1464	Belongs to the NlpA lipoprotein family
EYE35_RS06045	COG2011	ABC-type metal ion transport system permease component
EYE35_RS06050	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
EYE35_RS06065	COG2943	transferase activity, transferring hexosyl groups
EYE35_RS06075	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
EYE35_RS06085	COG3916	Acyl-homoserine-lactone synthase
EYE35_RS06110	COG0671	phosphoesterase, PA-phosphatase related
EYE35_RS06115	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
EYE35_RS06115	COG2010	Cytochrome c
EYE35_RS06120	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
EYE35_RS06130	COG2863	cytochrome
EYE35_RS06140	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EYE35_RS06145	COG1007	ATP synthesis coupled electron transport
EYE35_RS06160	COG0713	ATP synthesis coupled electron transport
EYE35_RS06165	COG0839	Belongs to the complex I subunit 6 family
EYE35_RS06170	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EYE35_RS06175	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
EYE35_RS06180	COG1034	ATP synthesis coupled electron transport
EYE35_RS06195	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EYE35_RS06195	COG0649	NAD binding
EYE35_RS06205	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EYE35_RS06215	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
EYE35_RS06220	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
EYE35_RS06250	COG1175	transmembrane transport
EYE35_RS06260	COG2390	Transcriptional regulator
EYE35_RS06265	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EYE35_RS06270	COG3685	Protein conserved in bacteria
EYE35_RS06285	COG0784	Response regulator, receiver
EYE35_RS06285	COG2205	protein histidine kinase activity
EYE35_RS06300	COG1558	bacterial-type flagellum-dependent cell motility
EYE35_RS06305	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
EYE35_RS06315	COG4786	Flagellar basal body rod
EYE35_RS06360	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
EYE35_RS06360	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
EYE35_RS06390	COG1684	flagellar biosynthetic protein fliR
EYE35_RS06435	COG1157	protein secretion by the type III secretion system
EYE35_RS06455	COG1677	Flagellar hook-basal body complex protein FliE
EYE35_RS06470	COG0643	Histidine kinase
EYE35_RS06470	COG2198	Histidine kinase
EYE35_RS06475	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
EYE35_RS06490	COG1192	Involved in chromosome partitioning
EYE35_RS06495	COG0840	transmembrane signaling receptor activity
EYE35_RS06500	COG2201	protein-glutamate methylesterase activity
EYE35_RS06505	COG0643	Histidine kinase
EYE35_RS06505	COG2198	Histidine kinase
EYE35_RS06595	COG5001	Diguanylate cyclase
EYE35_RS06600	COG0427	acetyl-CoA hydrolase
EYE35_RS06605	COG1028	Short-chain dehydrogenase reductase Sdr
EYE35_RS06625	COG0673	inositol 2-dehydrogenase activity
EYE35_RS06665	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EYE35_RS06670	COG1176	ABC-type spermidine putrescine transport system, permease component I
EYE35_RS06680	COG3842	ATPase activity
EYE35_RS06690	COG2326	polyphosphate kinase activity
EYE35_RS06695	COG2267	carboxylic ester hydrolase activity
EYE35_RS06730	COG1741	Belongs to the pirin family
EYE35_RS06760	COG0156	8-amino-7-oxononanoate synthase activity
EYE35_RS06770	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
EYE35_RS06780	COG0436	Aminotransferase
EYE35_RS06785	COG0860	N-Acetylmuramoyl-L-alanine amidase
EYE35_RS06790	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
EYE35_RS06795	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
EYE35_RS06810	COG0741	lytic transglycosylase activity
EYE35_RS06810	COG1196	nuclear chromosome segregation
EYE35_RS06810	COG0739	heme binding
EYE35_RS06815	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EYE35_RS06825	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
EYE35_RS06830	COG2814	Major facilitator Superfamily
EYE35_RS06840	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EYE35_RS06850	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EYE35_RS06895	COG2354	Protein conserved in bacteria
EYE35_RS06905	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
EYE35_RS06920	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
EYE35_RS06930	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EYE35_RS06940	COG0583	DNA-binding transcription factor activity
EYE35_RS06990	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
EYE35_RS06995	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
EYE35_RS07015	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
EYE35_RS07015	COG1796	DNA polymerase
EYE35_RS07020	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
EYE35_RS07040	COG2188	Transcriptional regulator
EYE35_RS07070	COG0559	Belongs to the binding-protein-dependent transport system permease family
EYE35_RS07095	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
EYE35_RS07105	COG1561	YicC-like family, N-terminal region
EYE35_RS07110	COG0194	GDP metabolic process
EYE35_RS07120	COG0626	cystathionine gamma-synthase activity
EYE35_RS07130	COG5002	protein histidine kinase activity
EYE35_RS07140	COG1840	ABC-type Fe3 transport system, periplasmic component
EYE35_RS07145	COG3956	TIGRFAM MazG family protein
EYE35_RS07150	COG1473	amidohydrolase
EYE35_RS07155	COG0010	Belongs to the arginase family
EYE35_RS07170	COG2890	protein-(glutamine-N5) methyltransferase activity
EYE35_RS07185	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
EYE35_RS07190	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EYE35_RS07205	COG0795	lipopolysaccharide-transporting ATPase activity
EYE35_RS07210	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EYE35_RS07220	COG3577	Aspartyl protease
EYE35_RS07225	COG2095	MarC family integral membrane protein
EYE35_RS07230	COG0488	(ABC) transporter
EYE35_RS07260	COG1959	2 iron, 2 sulfur cluster binding
EYE35_RS07265	COG0058	SHG alpha-glucan phosphorylase activity
EYE35_RS07275	COG0297	glycogen (starch) synthase activity
EYE35_RS07285	COG0033	Phosphoglucomutase
EYE35_RS07300	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EYE35_RS07300	COG2205	protein histidine kinase activity
EYE35_RS07325	COG0837	glucose binding
EYE35_RS07330	COG2723	6-phospho-beta-galactosidase activity
EYE35_RS07340	COG1653	transport
EYE35_RS07345	COG1175	transmembrane transport
EYE35_RS07350	COG0395	ABC-type sugar transport system, permease component
EYE35_RS07355	COG3842	ATPase activity
EYE35_RS07370	COG0517	IMP dehydrogenase activity
EYE35_RS07370	COG0516	GMP reductase activity
EYE35_RS07410	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EYE35_RS07430	COG0489	protein tyrosine kinase activity
EYE35_RS07430	COG2151	metal-sulfur cluster biosynthetic enzyme
EYE35_RS07435	COG0459	protein refolding
EYE35_RS07460	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EYE35_RS07465	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EYE35_RS07475	COG1902	pentaerythritol trinitrate reductase activity
EYE35_RS07480	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
EYE35_RS07490	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
EYE35_RS07495	COG1127	ABC transporter
EYE35_RS07510	COG5598	trimethylamine methyltransferase
EYE35_RS07525	COG4536	flavin adenine dinucleotide binding
EYE35_RS07530	COG4974	Belongs to the 'phage' integrase family
EYE35_RS07545	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
EYE35_RS07565	COG1648	precorrin-2 dehydrogenase activity
EYE35_RS07565	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EYE35_RS07570	COG2875	Belongs to the precorrin methyltransferase family
EYE35_RS07585	COG2099	Precorrin-6x reductase
EYE35_RS07640	COG2081	HI0933 family
EYE35_RS07645	COG1058	Belongs to the CinA family
EYE35_RS07645	COG1546	Belongs to the CinA family
EYE35_RS07665	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EYE35_RS07670	COG3852	Histidine kinase
EYE35_RS07675	COG2204	response regulator
EYE35_RS07680	COG5000	phosphorelay sensor kinase activity
EYE35_RS07685	COG2204	response regulator
EYE35_RS07690	COG0569	domain protein
EYE35_RS07705	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EYE35_RS07715	COG2084	Dehydrogenase
EYE35_RS07735	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
EYE35_RS07740	COG2814	Major facilitator Superfamily
EYE35_RS07745	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
EYE35_RS07770	COG4166	transmembrane transport
EYE35_RS07775	COG1028	Short-chain dehydrogenase reductase Sdr
EYE35_RS07780	COG2313	pseudouridylate synthase activity
EYE35_RS07810	COG2867	negative regulation of translational initiation
EYE35_RS07815	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
EYE35_RS07820	COG3909	cytochrome
EYE35_RS07825	COG2010	Cytochrome c
EYE35_RS07850	COG0753	catalase activity
EYE35_RS07870	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EYE35_RS07880	COG3108	Peptidase M15
EYE35_RS07890	COG0248	Ppx GppA phosphatase
EYE35_RS07900	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
EYE35_RS07950	COG2391	methyltransferase activity
EYE35_RS07955	COG2897	thiosulfate sulfurtransferase activity
EYE35_RS07960	COG0251	oxidation-reduction process
EYE35_RS07965	COG0166	Belongs to the GPI family
EYE35_RS07975	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
EYE35_RS07985	COG0431	NADPH-dependent FMN reductase
EYE35_RS07990	COG0798	PFAM Bile acid sodium symporter
EYE35_RS08030	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
EYE35_RS08035	COG2814	Major facilitator Superfamily
EYE35_RS08050	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EYE35_RS08055	COG0215	cysteine-tRNA ligase activity
EYE35_RS08080	COG0488	(ABC) transporter
EYE35_RS08085	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EYE35_RS08090	COG3494	Protein of unknown function (DUF1009)
EYE35_RS08095	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EYE35_RS08110	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EYE35_RS08120	COG0750	zinc metalloprotease
EYE35_RS08130	COG4589	Belongs to the CDS family
EYE35_RS08135	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
EYE35_RS08155	COG4166	transmembrane transport
EYE35_RS08160	COG0601	transmembrane transport
EYE35_RS08165	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EYE35_RS08170	COG4172	Belongs to the ABC transporter superfamily
EYE35_RS08190	COG5265	(ABC) transporter
EYE35_RS08210	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
EYE35_RS08210	COG2755	lipolytic protein G-D-S-L family
EYE35_RS08220	COG0446	pyridine nucleotide-disulphide oxidoreductase
EYE35_RS08220	COG0404	The glycine cleavage system catalyzes the degradation of glycine
EYE35_RS08235	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EYE35_RS08240	COG4235	cytochrome complex assembly
EYE35_RS08255	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
EYE35_RS08280	COG1285	pathogenesis
EYE35_RS08325	COG3842	ATPase activity
EYE35_RS08330	COG3842	ATPase activity
EYE35_RS08340	COG0395	ABC-type sugar transport system, permease component
EYE35_RS08365	COG1454	alcohol dehydrogenase
EYE35_RS08370	COG1295	ribonuclease BN
EYE35_RS08450	COG0129	dihydroxy-acid dehydratase activity
EYE35_RS08455	COG0800	Aldolase
EYE35_RS08465	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
EYE35_RS08495	COG0028	Belongs to the TPP enzyme family
EYE35_RS08500	COG0440	acetolactate synthase activity
EYE35_RS08505	COG1024	Enoyl-CoA hydratase
EYE35_RS08510	COG3088	subunit of a heme lyase
EYE35_RS08515	COG1138	Cytochrome C-type biogenesis protein
EYE35_RS08525	COG5425	PFAM Usg family protein
EYE35_RS08530	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
EYE35_RS08535	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
EYE35_RS08540	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EYE35_RS08560	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
EYE35_RS08570	COG0745	RESPONSE REGULATOR receiver
EYE35_RS08590	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EYE35_RS08615	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EYE35_RS08635	COG0717	Belongs to the dCTP deaminase family
EYE35_RS08665	COG0573	inorganic phosphate transmembrane transporter activity
EYE35_RS08670	COG0581	inorganic phosphate transmembrane transporter activity
EYE35_RS08675	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
EYE35_RS08685	COG0745	RESPONSE REGULATOR receiver
EYE35_RS08690	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EYE35_RS08700	COG1116	anion transmembrane transporter activity
EYE35_RS08715	COG0784	Response regulator, receiver
EYE35_RS08715	COG2205	protein histidine kinase activity
EYE35_RS08750	COG1131	(ABC) transporter
EYE35_RS08780	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EYE35_RS08800	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
EYE35_RS08805	COG3791	Glutathione-dependent formaldehyde-activating
EYE35_RS08825	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EYE35_RS08830	COG0693	protein deglycase activity
EYE35_RS08845	COG1091	dTDP-4-dehydrorhamnose reductase activity
EYE35_RS08850	COG1210	Utp--glucose-1-phosphate uridylyltransferase
EYE35_RS08855	COG0438	transferase activity, transferring glycosyl groups
EYE35_RS08860	COG1215	transferase activity, transferring glycosyl groups
EYE35_RS08870	COG3206	protein involved in exopolysaccharide biosynthesis
EYE35_RS08870	COG0489	protein tyrosine kinase activity
EYE35_RS08880	COG1132	(ABC) transporter
EYE35_RS08885	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
EYE35_RS08915	COG1215	transferase activity, transferring glycosyl groups
EYE35_RS08920	COG1215	transferase activity, transferring glycosyl groups
EYE35_RS08925	COG2273	Hydrolase Family 16
EYE35_RS08950	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
EYE35_RS08960	COG1388	LysM domain
EYE35_RS08960	COG0739	heme binding
EYE35_RS08970	COG0805	protein transport
EYE35_RS08980	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EYE35_RS08985	COG3842	ATPase activity
EYE35_RS08990	COG1028	Short-chain dehydrogenase reductase Sdr
EYE35_RS09000	COG0513	Belongs to the DEAD box helicase family
EYE35_RS09025	COG1007	ATP synthesis coupled electron transport
EYE35_RS09060	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
EYE35_RS09120	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
EYE35_RS09135	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EYE35_RS09140	COG3047	cAMP biosynthetic process
EYE35_RS09145	COG1960	acyl-CoA dehydrogenase activity
EYE35_RS09155	COG0546	phosphoglycolate phosphatase activity
EYE35_RS09160	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
EYE35_RS09165	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
EYE35_RS09180	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EYE35_RS09190	COG0697	spore germination
EYE35_RS09210	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
EYE35_RS09235	COG1830	Aldolase
EYE35_RS09240	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
EYE35_RS09245	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
EYE35_RS09250	COG0508	dehydrogenase complex catalyzes the overall conversion of
EYE35_RS09250	COG0022	dehydrogenase e1 component
EYE35_RS09255	COG0508	dehydrogenase complex catalyzes the overall conversion of
EYE35_RS09340	COG4695	Portal protein
EYE35_RS09355	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
EYE35_RS09360	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EYE35_RS09380	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
EYE35_RS09385	COG1127	ABC transporter
EYE35_RS09405	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
EYE35_RS09425	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
EYE35_RS09445	COG0366	Alpha amylase catalytic
EYE35_RS09455	COG0745	RESPONSE REGULATOR receiver
EYE35_RS09460	COG0840	transmembrane signaling receptor activity
EYE35_RS09470	COG0840	transmembrane signaling receptor activity
EYE35_RS09485	COG0745	RESPONSE REGULATOR receiver
EYE35_RS09500	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
EYE35_RS09505	COG0745	RESPONSE REGULATOR receiver
EYE35_RS09515	COG2873	o-acetylhomoserine
EYE35_RS09520	COG2968	Membrane
EYE35_RS09535	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
EYE35_RS09540	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
EYE35_RS09545	COG1329	Transcriptional regulator
EYE35_RS09550	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
EYE35_RS09555	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
EYE35_RS09595	COG2308	Evidence 4 Homologs of previously reported genes of
EYE35_RS09605	COG1793	dna ligase
EYE35_RS09605	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
EYE35_RS09625	COG0564	pseudouridine synthase activity
EYE35_RS09635	COG5002	protein histidine kinase activity
EYE35_RS09635	COG0784	Response regulator, receiver
EYE35_RS09645	COG1120	ATPase activity
EYE35_RS09650	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EYE35_RS09670	COG3842	ATPase activity
EYE35_RS09680	COG1177	transmembrane transport
EYE35_RS09685	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
EYE35_RS09715	COG0123	including yeast histone deacetylase and acetoin utilization protein
EYE35_RS09750	COG3871	stress protein (general stress protein 26)
EYE35_RS09775	COG2094	Belongs to the DNA glycosylase MPG family
EYE35_RS09785	COG0753	catalase activity
EYE35_RS09795	COG2124	cytochrome p450
EYE35_RS09805	COG1063	alcohol dehydrogenase
EYE35_RS09810	COG0156	8-amino-7-oxononanoate synthase activity
EYE35_RS09840	COG1028	Short-chain dehydrogenase reductase Sdr
EYE35_RS09850	COG1172	Belongs to the binding-protein-dependent transport system permease family
EYE35_RS09855	COG1172	Belongs to the binding-protein-dependent transport system permease family
EYE35_RS09860	COG1129	ABC transporter
EYE35_RS09870	COG0235	Class ii aldolase
EYE35_RS09875	COG1028	Short-chain dehydrogenase reductase Sdr
EYE35_RS09880	COG2188	Transcriptional regulator
EYE35_RS09900	COG0259	pyridoxamine-phosphate oxidase activity
EYE35_RS09905	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
EYE35_RS09955	COG0655	NAD(P)H dehydrogenase (quinone) activity
EYE35_RS09975	COG2132	Multicopper oxidase
EYE35_RS09980	COG1262	PFAM Formylglycine-generating sulfatase enzyme
EYE35_RS10010	COG0768	penicillin binding
EYE35_RS10015	COG0772	Belongs to the SEDS family
EYE35_RS10040	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
EYE35_RS10045	COG0174	glutamine synthetase
EYE35_RS10060	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EYE35_RS10070	COG0656	L-ascorbic acid biosynthetic process
EYE35_RS10105	COG1227	inorganic diphosphatase activity
EYE35_RS10115	COG2030	dehydratase
EYE35_RS10120	COG0196	riboflavin kinase activity
EYE35_RS10125	COG2983	Belongs to the UPF0260 family
EYE35_RS10140	COG0355	proton-transporting ATP synthase activity, rotational mechanism
EYE35_RS10170	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EYE35_RS10190	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
EYE35_RS10205	COG0287	Prephenate dehydrogenase
EYE35_RS10210	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EYE35_RS10255	COG0559	Belongs to the binding-protein-dependent transport system permease family
EYE35_RS10285	COG3023	N-Acetylmuramoyl-L-alanine amidase
EYE35_RS10315	COG0590	tRNA wobble adenosine to inosine editing
EYE35_RS10320	COG1187	pseudouridine synthase activity
EYE35_RS10365	COG1238	metal cluster binding
EYE35_RS10370	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
EYE35_RS10385	COG0318	PFAM AMP-dependent synthetase and ligase
EYE35_RS10390	COG1132	(ABC) transporter
EYE35_RS10420	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EYE35_RS10430	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
EYE35_RS10440	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
EYE35_RS10445	COG0107	imidazoleglycerol-phosphate synthase activity
EYE35_RS10455	COG1832	CoA-binding protein
EYE35_RS10460	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EYE35_RS10475	COG2814	Major facilitator Superfamily
EYE35_RS10500	COG1573	uracil-dna glycosylase
EYE35_RS10530	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
EYE35_RS10555	COG3042	response to heat
EYE35_RS10560	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
EYE35_RS10580	COG1376	ErfK ybiS ycfS ynhG family protein
EYE35_RS10585	COG2514	catechol 2,3-dioxygenase activity
EYE35_RS10600	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
EYE35_RS10605	COG1214	PFAM Peptidase M22, glycoprotease
EYE35_RS10615	COG1744	ABC transporter substrate-binding protein PnrA-like
EYE35_RS10620	COG3845	ABC transporter
EYE35_RS10625	COG4603	Belongs to the binding-protein-dependent transport system permease family
EYE35_RS10630	COG1079	Belongs to the binding-protein-dependent transport system permease family
EYE35_RS10635	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
EYE35_RS10640	COG0730	response to heat
EYE35_RS10650	COG0534	Mate efflux family protein
EYE35_RS10675	COG1960	acyl-CoA dehydrogenase activity
EYE35_RS10685	COG0183	Belongs to the thiolase family
EYE35_RS10690	COG1250	3-hydroxyacyl-CoA dehydrogenase
EYE35_RS10690	COG1024	Enoyl-CoA hydratase
EYE35_RS10700	COG0509	glycine decarboxylation via glycine cleavage system
EYE35_RS10705	COG0404	The glycine cleavage system catalyzes the degradation of glycine
EYE35_RS10710	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EYE35_RS10710	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EYE35_RS10720	COG4770	biotin carboxylase activity
EYE35_RS10745	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EYE35_RS10760	COG3800	Transcriptional regulator
EYE35_RS10760	COG1396	sequence-specific DNA binding
EYE35_RS10770	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
EYE35_RS10800	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EYE35_RS10800	COG1754	DNA topoisomerase type I activity
EYE35_RS10805	COG0758	DNA mediated transformation
EYE35_RS10815	COG1122	ATPase activity
EYE35_RS10820	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
EYE35_RS10825	COG1268	BioY protein
EYE35_RS10835	COG0583	DNA-binding transcription factor activity
EYE35_RS10840	COG0306	phosphate transporter
EYE35_RS10845	COG0483	inositol monophosphate 1-phosphatase activity
EYE35_RS10860	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
EYE35_RS10860	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
EYE35_RS10860	COG0506	proline dehydrogenase activity
EYE35_RS10865	COG1522	sequence-specific DNA binding
EYE35_RS10885	COG1028	Short-chain dehydrogenase reductase Sdr
EYE35_RS10890	COG3842	ATPase activity
EYE35_RS10905	COG1177	transmembrane transport
EYE35_RS10910	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
EYE35_RS10935	COG0463	Glycosyl transferase, family 2
EYE35_RS10940	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EYE35_RS10945	COG3264	Mechanosensitive ion channel
EYE35_RS10945	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
EYE35_RS10955	COG0494	nUDIX hydrolase
EYE35_RS10965	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
EYE35_RS10970	COG0415	Belongs to the DNA photolyase family
EYE35_RS10975	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EYE35_RS10980	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
EYE35_RS11000	COG0114	fumarate hydratase activity
EYE35_RS11020	COG0785	Cytochrome C biogenesis protein
EYE35_RS11030	COG1530	ribonuclease E activity
EYE35_RS11035	COG2204	response regulator
EYE35_RS11045	COG0047	phosphoribosylformylglycinamidine synthase activity
EYE35_RS11050	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EYE35_RS11055	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
EYE35_RS11065	COG0646	methionine synthase
EYE35_RS11065	COG1410	methionine synthase
EYE35_RS11075	COG5012	cobalamin binding
EYE35_RS11090	COG0277	FAD linked oxidase domain protein
EYE35_RS11105	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EYE35_RS11115	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
EYE35_RS11120	COG0849	cell division
EYE35_RS11125	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
EYE35_RS11190	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
EYE35_RS11215	COG0489	protein tyrosine kinase activity
EYE35_RS11225	COG3135	benzoate transporter
EYE35_RS11230	COG0210	DNA helicase
EYE35_RS11240	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
EYE35_RS11280	COG0556	nucleotide-excision repair
EYE35_RS11375	COG0784	Response regulator, receiver
EYE35_RS11395	COG2197	response regulator
EYE35_RS11410	COG3920	Histidine kinase
EYE35_RS11410	COG2202	Pas domain
EYE35_RS11425	COG0583	DNA-binding transcription factor activity
EYE35_RS11440	COG1278	Cold shock
EYE35_RS11470	COG1703	isobutyryl-CoA mutase activity
EYE35_RS11480	COG1643	Atp-dependent helicase
EYE35_RS11490	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EYE35_RS11505	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EYE35_RS11525	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
EYE35_RS11555	COG0303	'Molybdopterin
EYE35_RS11560	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
EYE35_RS11565	COG0658	competence protein
EYE35_RS11565	COG2333	competence protein COMEC
EYE35_RS11600	COG0525	valine-tRNA ligase activity
EYE35_RS11615	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
EYE35_RS11625	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EYE35_RS11635	COG0308	aminopeptidase N
EYE35_RS11640	COG0415	Belongs to the DNA photolyase family
EYE35_RS11645	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
EYE35_RS11655	COG0484	heat shock protein binding
EYE35_RS11680	COG0006	proline dipeptidase activity
EYE35_RS11690	COG2166	iron-sulfur cluster assembly
EYE35_RS11700	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
EYE35_RS11705	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
EYE35_RS11800	COG1518	maintenance of DNA repeat elements
EYE35_RS11805	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
EYE35_RS11810	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EYE35_RS11815	COG1595	DNA-templated transcription, initiation
EYE35_RS11830	COG1028	Short-chain dehydrogenase reductase Sdr
EYE35_RS11835	COG1733	regulation of RNA biosynthetic process
EYE35_RS11905	COG0514	ATP-dependent DNA helicase (RecQ)
EYE35_RS11915	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
EYE35_RS11920	COG1530	ribonuclease E activity
EYE35_RS11925	COG0424	maF-like protein
EYE35_RS11935	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EYE35_RS11935	COG3153	acetyltransferase
EYE35_RS11950	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EYE35_RS11960	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
EYE35_RS12005	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EYE35_RS12020	COG1396	sequence-specific DNA binding
EYE35_RS12035	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EYE35_RS12040	COG1116	anion transmembrane transporter activity
EYE35_RS12045	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EYE35_RS12050	COG0351	phosphomethylpyrimidine kinase
EYE35_RS12055	COG0352	thiamine-phosphate diphosphorylase activity
EYE35_RS12060	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
EYE35_RS12065	COG1196	nuclear chromosome segregation
EYE35_RS12065	COG0739	heme binding
EYE35_RS12065	COG0741	lytic transglycosylase activity
EYE35_RS12075	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EYE35_RS12080	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
EYE35_RS12095	COG0471	metal ion transport
EYE35_RS12095	COG3273	potassium ion transport
EYE35_RS12100	COG1692	metallophosphoesterase
EYE35_RS12105	COG1201	RNA secondary structure unwinding
EYE35_RS12120	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
EYE35_RS12140	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EYE35_RS12145	COG0037	tRNA processing
EYE35_RS12155	COG2885	chlorophyll binding
EYE35_RS12170	COG0848	biopolymer transport protein
EYE35_RS12180	COG0824	Thioesterase
EYE35_RS12195	COG0084	hydrolase, TatD family'
EYE35_RS12220	COG0181	hydroxymethylbilane synthase activity
EYE35_RS12235	COG0408	coproporphyrinogen oxidase activity
EYE35_RS12245	COG1028	Short-chain dehydrogenase reductase Sdr
EYE35_RS12255	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
EYE35_RS12265	COG1686	Belongs to the peptidase S11 family
EYE35_RS12285	COG0348	domain, Protein
EYE35_RS12290	COG2010	Cytochrome c
EYE35_RS12315	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EYE35_RS12320	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EYE35_RS12325	COG0438	transferase activity, transferring glycosyl groups
EYE35_RS12330	COG4172	Belongs to the ABC transporter superfamily
EYE35_RS12335	COG4239	(ABC) transporter, permease
EYE35_RS12340	COG4174	ABC transporter (Permease)
EYE35_RS12345	COG4166	transmembrane transport
EYE35_RS12370	COG0737	Belongs to the 5'-nucleotidase family
EYE35_RS12410	COG0583	DNA-binding transcription factor activity
EYE35_RS12420	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
EYE35_RS12465	COG1183	phosphatidylcholine synthase activity
EYE35_RS12475	COG1522	sequence-specific DNA binding
EYE35_RS12480	COG0686	Belongs to the AlaDH PNT family
EYE35_RS12490	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EYE35_RS12495	COG0165	Argininosuccinate lyase
EYE35_RS12515	COG0019	diaminopimelate decarboxylase activity
EYE35_RS12530	COG2884	Cell division ATP-binding protein ftsE
EYE35_RS12550	COG1763	Mo-molybdopterin cofactor biosynthetic process
EYE35_RS12585	COG1960	acyl-CoA dehydrogenase activity
EYE35_RS12590	COG0009	L-threonylcarbamoyladenylate synthase
EYE35_RS12595	COG2818	Glycosylase
EYE35_RS12615	COG2890	protein-(glutamine-N5) methyltransferase activity
EYE35_RS12625	COG0142	geranyltranstransferase activity
EYE35_RS12650	COG0582	viral genome integration into host DNA
EYE35_RS12745	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EYE35_RS12750	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
EYE35_RS12755	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EYE35_RS12755	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EYE35_RS12775	COG1596	polysaccharide export
EYE35_RS12780	COG1846	Transcriptional regulator
EYE35_RS12800	COG0534	Mate efflux family protein
EYE35_RS12810	COG2326	polyphosphate kinase activity
EYE35_RS12825	COG0187	DNA topoisomerase II activity
EYE35_RS12830	COG1312	Catalyzes the dehydration of D-mannonate
EYE35_RS12845	COG1136	(ABC) transporter
EYE35_RS12850	COG4591	ABC-type transport system involved in lipoprotein release permease component
EYE35_RS12855	COG0442	prolyl-tRNA aminoacylation
EYE35_RS12860	COG0628	permease
EYE35_RS12870	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
EYE35_RS12875	COG0248	Ppx GppA phosphatase
EYE35_RS12890	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
EYE35_RS12915	COG0535	radical SAM domain protein
EYE35_RS12920	COG0535	radical SAM domain protein
EYE35_RS12930	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
EYE35_RS12950	COG1492	cobalamin metabolic process
EYE35_RS12960	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EYE35_RS12970	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EYE35_RS12975	COG1872	DUF167
EYE35_RS12990	COG4608	Belongs to the ABC transporter superfamily
EYE35_RS12995	COG0444	Belongs to the ABC transporter superfamily
EYE35_RS13000	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EYE35_RS13005	COG0601	transmembrane transport
EYE35_RS13030	COG0346	lactoylglutathione lyase activity
EYE35_RS13060	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
EYE35_RS13075	COG0513	Belongs to the DEAD box helicase family
EYE35_RS13090	COG0596	Alpha beta hydrolase
EYE35_RS13100	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
EYE35_RS13105	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
EYE35_RS13135	COG3620	sequence-specific DNA binding
EYE35_RS13135	COG0617	tRNA 3'-terminal CCA addition
EYE35_RS13135	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
EYE35_RS13145	COG0012	GTP binding
EYE35_RS13200	COG0457	Tetratricopeptide repeat
EYE35_RS13205	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
EYE35_RS13220	COG0745	RESPONSE REGULATOR receiver
EYE35_RS13245	COG0679	Auxin Efflux Carrier
EYE35_RS13250	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
EYE35_RS13255	COG1671	Belongs to the UPF0178 family
EYE35_RS13260	COG2423	ornithine cyclodeaminase activity
EYE35_RS13275	COG4106	trans-aconitate 2-methyltransferase activity
EYE35_RS13285	COG0697	spore germination
EYE35_RS13290	COG0473	3-isopropylmalate dehydrogenase activity
EYE35_RS13330	COG0799	negative regulation of ribosome biogenesis
EYE35_RS13360	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
EYE35_RS13365	COG0242	peptide deformylase activity
EYE35_RS13370	COG0242	peptide deformylase activity
EYE35_RS13375	COG0242	peptide deformylase activity
EYE35_RS13400	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EYE35_RS13400	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
EYE35_RS13410	COG0741	lytic transglycosylase activity
EYE35_RS13415	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EYE35_RS13425	COG2897	thiosulfate sulfurtransferase activity
EYE35_RS13435	COG0004	ammonium transporteR
EYE35_RS13440	COG0347	Belongs to the P(II) protein family
EYE35_RS13455	COG2853	Lipoprotein
EYE35_RS13465	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EYE35_RS13490	COG2154	pterin-4-alpha-carbinolamine dehydratase
EYE35_RS13495	COG0678	peroxiredoxin activity
EYE35_RS13505	COG0742	ribosomal rna small subunit methyltransferase
EYE35_RS13510	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EYE35_RS13525	COG1121	(ABC) transporter
EYE35_RS13530	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EYE35_RS13535	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EYE35_RS13570	COG1028	Short-chain dehydrogenase reductase Sdr
EYE35_RS13580	COG0312	modulator of DNA gyrase
EYE35_RS13595	COG1028	Short-chain dehydrogenase reductase Sdr
EYE35_RS13610	COG0848	biopolymer transport protein
EYE35_RS13620	COG0024	Methionine aminopeptidase
EYE35_RS13625	COG1546	Belongs to the CinA family
EYE35_RS13625	COG1058	Belongs to the CinA family
EYE35_RS13640	COG0583	DNA-binding transcription factor activity
EYE35_RS13655	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
EYE35_RS13660	COG0285	dihydrofolate synthase activity
EYE35_RS13670	COG0793	Belongs to the peptidase S41A family
EYE35_RS13685	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EYE35_RS13690	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
EYE35_RS13730	COG1116	anion transmembrane transporter activity
EYE35_RS13740	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EYE35_RS13770	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
EYE35_RS13775	COG1877	trehalose-phosphatase activity
EYE35_RS13780	COG4187	Peptidase family M20/M25/M40
EYE35_RS13805	COG0737	Belongs to the 5'-nucleotidase family
EYE35_RS13815	COG0167	dihydroorotate dehydrogenase activity
EYE35_RS13835	COG0604	alcohol dehydrogenase
EYE35_RS13840	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EYE35_RS13840	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EYE35_RS13855	COG0508	dehydrogenase complex catalyzes the overall conversion of
EYE35_RS13860	COG0567	Dehydrogenase, E1 component
EYE35_RS13885	COG2301	Belongs to the HpcH HpaI aldolase family
EYE35_RS13900	COG2030	dehydratase
EYE35_RS13940	COG1802	Transcriptional regulator
EYE35_RS13975	COG1072	(Pantothenic acid kinase))
EYE35_RS14000	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
EYE35_RS14000	COG2111	Na H antiporter
EYE35_RS14005	COG1006	Multisubunit Na H antiporter MnhC subunit
EYE35_RS14010	COG0651	ATP synthesis coupled electron transport
EYE35_RS14015	COG1863	multisubunit Na H antiporter MnhE subunit
EYE35_RS14020	COG2212	antiporter activity
EYE35_RS14025	COG1320	monovalent cation:proton antiporter activity
EYE35_RS14045	COG1573	uracil-dna glycosylase
EYE35_RS14080	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
EYE35_RS14105	COG1253	flavin adenine dinucleotide binding
EYE35_RS14115	COG2304	oxidoreductase activity
EYE35_RS14120	COG0071	Belongs to the small heat shock protein (HSP20) family
EYE35_RS14130	COG0247	lactate metabolic process
EYE35_RS14135	COG0277	FAD linked oxidase domain protein
EYE35_RS14140	COG0277	FAD linked oxidase domain protein
EYE35_RS14165	COG0714	Associated with various cellular activities
EYE35_RS14185	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EYE35_RS14185	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EYE35_RS14195	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EYE35_RS14200	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
EYE35_RS14205	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EYE35_RS14210	COG2885	chlorophyll binding
EYE35_RS14220	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
EYE35_RS14230	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
EYE35_RS14245	COG0640	Transcriptional regulator
EYE35_RS14250	COG0318	PFAM AMP-dependent synthetase and ligase
EYE35_RS14255	COG1192	Involved in chromosome partitioning
EYE35_RS14270	COG0336	Belongs to the RNA methyltransferase TrmD family
EYE35_RS14280	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
EYE35_RS14310	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
EYE35_RS14330	COG3852	Histidine kinase
EYE35_RS14350	COG0594	ribonuclease P activity
EYE35_RS14380	COG0218	Necessary for normal cell division and for the maintenance of normal septation
EYE35_RS14385	COG1028	Short-chain dehydrogenase reductase Sdr
EYE35_RS14405	COG0314	molybdopterin synthase activity
EYE35_RS14415	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
EYE35_RS14420	COG0322	excinuclease ABC activity
EYE35_RS14430	COG1028	Short-chain dehydrogenase reductase Sdr
EYE35_RS14440	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
EYE35_RS14440	COG0616	signal peptide processing
EYE35_RS14460	COG3383	formate dehydrogenase (NAD+) activity
EYE35_RS14465	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
EYE35_RS14480	COG0297	glycogen (starch) synthase activity
EYE35_RS14480	COG0438	transferase activity, transferring glycosyl groups
EYE35_RS14485	COG0745	RESPONSE REGULATOR receiver
EYE35_RS14505	COG4221	oxidoreductase activity
EYE35_RS14530	COG1595	DNA-templated transcription, initiation
EYE35_RS14535	COG3806	Anti-sigma factor
EYE35_RS14545	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
EYE35_RS14550	COG0612	Peptidase, M16
EYE35_RS14555	COG0612	Peptidase, M16
EYE35_RS14565	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
EYE35_RS14590	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
EYE35_RS14605	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
EYE35_RS14645	COG0438	transferase activity, transferring glycosyl groups
EYE35_RS14680	COG0587	DNA-directed DNA polymerase activity
EYE35_RS14685	COG2951	lytic endotransglycosylase activity
EYE35_RS14690	COG0557	exoribonuclease II activity
EYE35_RS14710	COG2323	membrane
EYE35_RS14730	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
EYE35_RS14735	COG0142	geranyltranstransferase activity
EYE35_RS14740	COG1722	exodeoxyribonuclease VII activity
EYE35_RS14745	COG0123	including yeast histone deacetylase and acetoin utilization protein
EYE35_RS14750	COG0745	RESPONSE REGULATOR receiver
EYE35_RS14755	COG1846	Transcriptional regulator
EYE35_RS14760	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EYE35_RS14775	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
EYE35_RS14785	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EYE35_RS14845	COG1137	ATPase activity
EYE35_RS14850	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
EYE35_RS14855	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EYE35_RS14865	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
EYE35_RS14900	COG0494	nUDIX hydrolase
EYE35_RS14905	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
EYE35_RS14910	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EYE35_RS14925	COG2003	Belongs to the UPF0758 family
EYE35_RS14950	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EYE35_RS14960	COG1070	Carbohydrate kinase
EYE35_RS14965	COG1129	ABC transporter
EYE35_RS14970	COG4214	carbohydrate transport
EYE35_RS14975	COG4213	ABC transporter substrate-binding protein
EYE35_RS14980	COG1940	carbohydrate kinase activity
EYE35_RS14985	COG0729	surface antigen
EYE35_RS14990	COG2911	Protein conserved in bacteria
EYE35_RS14995	COG1295	ribonuclease BN
EYE35_RS15010	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EYE35_RS15020	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EYE35_RS15040	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
EYE35_RS15045	COG1040	competence protein
EYE35_RS15075	COG3034	peptidoglycan biosynthetic process
EYE35_RS15080	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
EYE35_RS15085	COG1132	(ABC) transporter
EYE35_RS15090	COG1132	(ABC) transporter
EYE35_RS15095	COG0617	tRNA 3'-terminal CCA addition
EYE35_RS15100	COG0494	nUDIX hydrolase
EYE35_RS15115	COG0745	RESPONSE REGULATOR receiver
EYE35_RS15130	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
EYE35_RS15160	COG0280	phosphate acetyltransferase
EYE35_RS15160	COG0281	malic enzyme
EYE35_RS15165	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
EYE35_RS15170	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
EYE35_RS15175	COG1420	regulation of RNA biosynthetic process
EYE35_RS15185	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
EYE35_RS15195	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EYE35_RS15200	COG2832	Protein of unknown function (DUF454)
EYE35_RS15225	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
EYE35_RS15230	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
EYE35_RS15235	COG1981	membrane
EYE35_RS15240	COG0424	maF-like protein
EYE35_RS15245	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
EYE35_RS15250	COG0237	dephospho-CoA kinase activity
EYE35_RS15255	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
EYE35_RS15280	COG2840	Smr protein MutS2
EYE35_RS15290	COG1609	Transcriptional regulator
EYE35_RS15300	COG0673	inositol 2-dehydrogenase activity
EYE35_RS15305	COG1129	ABC transporter
EYE35_RS15310	COG1172	Belongs to the binding-protein-dependent transport system permease family
EYE35_RS15315	COG1879	ABC-type sugar transport system periplasmic component
EYE35_RS15320	COG3794	PFAM blue (type 1) copper domain protein
EYE35_RS15345	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
EYE35_RS15355	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
EYE35_RS15360	COG3243	poly(R)-hydroxyalkanoic acid synthase
EYE35_RS15365	COG2267	carboxylic ester hydrolase activity
EYE35_RS15380	COG2200	EAL domain
EYE35_RS15395	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
EYE35_RS15410	COG2205	protein histidine kinase activity
EYE35_RS15415	COG0745	RESPONSE REGULATOR receiver
EYE35_RS15420	COG3237	CsbD-like
EYE35_RS15440	COG0784	Response regulator, receiver
EYE35_RS15450	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EYE35_RS15515	COG1129	ABC transporter
EYE35_RS15550	COG0022	dehydrogenase e1 component
EYE35_RS15555	COG1960	acyl-CoA dehydrogenase activity
EYE35_RS15560	COG0583	DNA-binding transcription factor activity
EYE35_RS15565	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
EYE35_RS15595	COG1749	Flagellar hook protein flgE
EYE35_RS15610	COG1706	bacterial-type flagellum-dependent cell motility
EYE35_RS15615	COG0784	Response regulator, receiver
EYE35_RS15615	COG4191	Histidine kinase
EYE35_RS15625	COG1338	Plays a role in the flagellum-specific transport system
EYE35_RS15630	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EYE35_RS15640	COG1766	The M ring may be actively involved in energy transduction
EYE35_RS15660	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
EYE35_RS15675	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
EYE35_RS15685	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
EYE35_RS15700	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
EYE35_RS15710	COG4786	Flagellar basal body rod
EYE35_RS15715	COG4786	Flagellar basal body rod
EYE35_RS15720	COG1987	bacterial-type flagellum assembly
EYE35_RS15725	COG1677	Flagellar hook-basal body complex protein FliE
EYE35_RS15730	COG1558	bacterial-type flagellum-dependent cell motility
EYE35_RS15735	COG1815	bacterial-type flagellum-dependent cell motility
EYE35_RS15760	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
EYE35_RS15775	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
EYE35_RS15800	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EYE35_RS15820	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
EYE35_RS15825	COG0560	Phosphoserine phosphatase
EYE35_RS15830	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
EYE35_RS15835	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EYE35_RS15845	COG0183	Belongs to the thiolase family
EYE35_RS15850	COG4953	penicillin-binding protein 1C
EYE35_RS15855	COG2373	Large extracellular alpha-helical protein
EYE35_RS15860	COG2205	protein histidine kinase activity
EYE35_RS15860	COG5002	protein histidine kinase activity
EYE35_RS15860	COG0784	Response regulator, receiver
EYE35_RS15870	COG0514	ATP-dependent DNA helicase (RecQ)
EYE35_RS15890	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
EYE35_RS15900	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
EYE35_RS15910	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
EYE35_RS15915	COG1335	isochorismatase
EYE35_RS15920	COG1028	Short-chain dehydrogenase reductase Sdr
EYE35_RS15925	COG3734	2-keto-3-deoxy-galactonokinase
EYE35_RS15930	COG0366	Alpha amylase catalytic
EYE35_RS15935	COG2271	Major facilitator Superfamily
EYE35_RS15945	COG0438	transferase activity, transferring glycosyl groups
EYE35_RS15960	COG0288	reversible hydration of carbon dioxide
EYE35_RS15970	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EYE35_RS15975	COG0791	NLP P60 protein
EYE35_RS15980	COG3214	Protein conserved in bacteria
EYE35_RS16005	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EYE35_RS16035	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
EYE35_RS16055	COG0625	glutathione transferase activity
EYE35_RS16080	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EYE35_RS16100	COG0284	orotidine-5'-phosphate decarboxylase activity
EYE35_RS16105	COG1940	carbohydrate kinase activity
EYE35_RS16115	COG0542	response to heat
EYE35_RS16120	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
EYE35_RS16125	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
EYE35_RS16190	COG4774	siderophore transport
EYE35_RS16195	COG2382	esterase
EYE35_RS16230	COG1414	Transcriptional regulator
EYE35_RS16240	COG1176	ABC-type spermidine putrescine transport system, permease component I
EYE35_RS16260	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EYE35_RS16270	COG0235	Class ii aldolase
EYE35_RS16275	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
EYE35_RS16280	COG0028	Belongs to the TPP enzyme family
EYE35_RS16300	COG2188	Transcriptional regulator
EYE35_RS16305	COG0277	FAD linked oxidase domain protein
EYE35_RS16355	COG0515	serine threonine protein kinase
EYE35_RS16355	COG3266	domain, Protein
EYE35_RS16360	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EYE35_RS16375	COG1262	PFAM Formylglycine-generating sulfatase enzyme
EYE35_RS16405	COG2130	NADP-dependent
EYE35_RS16415	COG1024	Enoyl-CoA hydratase
EYE35_RS16415	COG1250	3-hydroxyacyl-CoA dehydrogenase
EYE35_RS16420	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EYE35_RS16425	COG1012	belongs to the aldehyde dehydrogenase family
EYE35_RS16430	COG0318	PFAM AMP-dependent synthetase and ligase
EYE35_RS16455	COG0154	amidase activity
EYE35_RS16470	COG0747	negative chemotaxis
EYE35_RS16475	COG0601	transmembrane transport
EYE35_RS16480	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EYE35_RS16485	COG4172	Belongs to the ABC transporter superfamily
EYE35_RS16490	COG3938	Belongs to the proline racemase family
EYE35_RS16495	COG1177	transmembrane transport
EYE35_RS16505	COG3842	ATPase activity
EYE35_RS16540	COG2390	Transcriptional regulator
EYE35_RS16550	COG1172	Belongs to the binding-protein-dependent transport system permease family
EYE35_RS16565	COG1028	Short-chain dehydrogenase reductase Sdr
EYE35_RS16565	COG3347	Dehydrogenase
EYE35_RS16570	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EYE35_RS16595	COG0765	amino acid transport
EYE35_RS16600	COG0765	amino acid transport
EYE35_RS16615	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EYE35_RS16620	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EYE35_RS16625	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
EYE35_RS16645	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
EYE35_RS16650	COG1984	allophanate hydrolase subunit 2
EYE35_RS16655	COG1802	Transcriptional regulator
EYE35_RS16670	COG1802	Transcriptional regulator
EYE35_RS16675	COG0006	proline dipeptidase activity
EYE35_RS16690	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
EYE35_RS16695	COG1028	Short-chain dehydrogenase reductase Sdr
EYE35_RS16700	COG0436	Aminotransferase
EYE35_RS16715	COG0583	DNA-binding transcription factor activity
EYE35_RS16740	COG0642	Histidine kinase
EYE35_RS16765	COG0754	glutathionylspermidine amidase activity
EYE35_RS16780	COG0708	Exodeoxyribonuclease III
EYE35_RS16815	COG4774	siderophore transport
EYE35_RS16825	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EYE35_RS16830	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EYE35_RS16835	COG1120	ATPase activity
EYE35_RS16860	COG0583	DNA-binding transcription factor activity
EYE35_RS16870	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
EYE35_RS16875	COG1840	ABC-type Fe3 transport system, periplasmic component
EYE35_RS16880	COG3842	ATPase activity
EYE35_RS16885	COG1176	ABC-type spermidine putrescine transport system, permease component I
EYE35_RS16890	COG1177	transmembrane transport
EYE35_RS16900	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EYE35_RS16905	COG1120	ATPase activity
EYE35_RS16955	COG1136	(ABC) transporter
EYE35_RS16955	COG0577	efflux transmembrane transporter activity
EYE35_RS16960	COG0577	efflux transmembrane transporter activity
EYE35_RS16960	COG1136	(ABC) transporter
EYE35_RS16965	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
EYE35_RS16980	COG0154	amidase activity
EYE35_RS16990	COG3706	GGDEF domain
EYE35_RS17010	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EYE35_RS17085	COG3706	GGDEF domain
EYE35_RS17100	COG2962	Rard protein
EYE35_RS17115	COG3842	ATPase activity
EYE35_RS17145	COG1346	cytolysis
EYE35_RS17155	COG0471	metal ion transport
EYE35_RS17155	COG3273	potassium ion transport
EYE35_RS17180	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EYE35_RS17185	COG2244	polysaccharide biosynthetic process
EYE35_RS17200	COG3284	Transcriptional regulator
EYE35_RS17205	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EYE35_RS17360	COG0697	spore germination
EYE35_RS17380	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
EYE35_RS17390	COG0840	transmembrane signaling receptor activity
EYE35_RS17395	COG0745	RESPONSE REGULATOR receiver
EYE35_RS17400	COG0800	Aldolase
EYE35_RS17455	COG1283	sodium-dependent phosphate transmembrane transporter activity
EYE35_RS17460	COG1653	transport
EYE35_RS17465	COG1175	transmembrane transport
EYE35_RS17470	COG0395	ABC-type sugar transport system, permease component
EYE35_RS17510	COG0714	Associated with various cellular activities
EYE35_RS17515	COG1131	(ABC) transporter
EYE35_RS17520	COG0842	Transport permease protein
EYE35_RS17525	COG0405	Gamma-glutamyltransferase
EYE35_RS17585	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EYE35_RS17600	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EYE35_RS17605	COG0601	transmembrane transport
EYE35_RS17610	COG0747	negative chemotaxis
EYE35_RS17625	COG0601	transmembrane transport
EYE35_RS17630	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EYE35_RS17635	COG4172	Belongs to the ABC transporter superfamily
EYE35_RS17685	COG4608	Belongs to the ABC transporter superfamily
EYE35_RS17690	COG0444	Belongs to the ABC transporter superfamily
EYE35_RS17695	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EYE35_RS17700	COG0601	transmembrane transport
EYE35_RS17705	COG0747	negative chemotaxis
EYE35_RS17715	COG2951	lytic endotransglycosylase activity
EYE35_RS17725	COG1509	lysine 2,3-aminomutase activity
EYE35_RS17730	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
EYE35_RS17740	COG4771	TonB-dependent receptor
EYE35_RS17745	COG4604	ABC transporter, ATP-binding protein
EYE35_RS17750	COG4605	iron ion homeostasis
EYE35_RS17755	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EYE35_RS17760	COG2205	protein histidine kinase activity
EYE35_RS17770	COG0778	Nitroreductase
EYE35_RS17775	COG0420	3'-5' exonuclease activity
EYE35_RS17780	COG4717	serine-type aminopeptidase activity
EYE35_RS17795	COG1271	oxidase subunit
EYE35_RS17800	COG1294	oxidase, subunit
EYE35_RS17820	COG0310	cobalt ion transport
EYE35_RS17830	COG1529	Aldehyde oxidase and xanthine dehydrogenase
EYE35_RS17835	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
EYE35_RS17840	COG2080	2 iron, 2 sulfur cluster binding
EYE35_RS17850	COG2207	Transcriptional regulator
EYE35_RS17855	COG0667	Aldo Keto reductase
EYE35_RS17860	COG0443	Heat shock 70 kDa protein
EYE35_RS17870	COG2914	Belongs to the UPF0125 (RnfH) family
EYE35_RS17880	COG4659	FMN binding
EYE35_RS17890	COG4656	Part of a membrane complex involved in electron transport
EYE35_RS17895	COG2878	Part of a membrane complex involved in electron transport
EYE35_RS17905	COG0426	domain, Protein
EYE35_RS17910	COG0633	Ferredoxin
EYE35_RS17915	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
EYE35_RS17930	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
EYE35_RS17945	COG1797	cobyrinic acid a,c-diamide synthase activity
EYE35_RS17950	COG0183	Belongs to the thiolase family
EYE35_RS17960	COG1960	acyl-CoA dehydrogenase activity
EYE35_RS17965	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EYE35_RS17980	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EYE35_RS17990	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
EYE35_RS18000	COG1953	Uracil, thiamine, allantoin
EYE35_RS18005	COG0730	response to heat
EYE35_RS18010	COG2084	Dehydrogenase
EYE35_RS18015	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
EYE35_RS18030	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EYE35_RS18030	COG1116	anion transmembrane transporter activity
EYE35_RS18035	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EYE35_RS18065	COG0392	lysyltransferase activity
EYE35_RS18070	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EYE35_RS18075	COG0842	Transport permease protein
EYE35_RS18075	COG1129	ABC transporter
EYE35_RS18080	COG0842	Transport permease protein
EYE35_RS18090	COG0583	DNA-binding transcription factor activity
EYE35_RS18095	COG0028	Belongs to the TPP enzyme family
EYE35_RS18100	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
EYE35_RS18105	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EYE35_RS18120	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
EYE35_RS18135	COG1053	succinate dehydrogenase
EYE35_RS18150	COG2855	membrane
EYE35_RS18160	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EYE35_RS18180	COG3386	PFAM SMP-30 Gluconolaconase
EYE35_RS18185	COG4529	Protein conserved in bacteria
EYE35_RS18215	COG3443	Belongs to the bacterial solute-binding protein 9 family
EYE35_RS18225	COG0628	permease
EYE35_RS18240	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EYE35_RS18250	COG0625	glutathione transferase activity
EYE35_RS18265	COG0840	transmembrane signaling receptor activity
EYE35_RS18280	COG3920	Histidine kinase
EYE35_RS18300	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EYE35_RS18325	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
EYE35_RS18330	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
EYE35_RS18340	COG1595	DNA-templated transcription, initiation
EYE35_RS18350	COG0670	Belongs to the BI1 family
EYE35_RS18365	COG2824	Alkylphosphonate utilization operon protein PhnA
EYE35_RS18380	COG0642	Histidine kinase
EYE35_RS18385	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
EYE35_RS18390	COG2194	sulfuric ester hydrolase activity
EYE35_RS18400	COG0840	transmembrane signaling receptor activity
EYE35_RS18410	COG1132	(ABC) transporter
EYE35_RS18415	COG0641	radical SAM
EYE35_RS18420	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EYE35_RS18425	COG4607	ABC-type enterochelin transport system periplasmic component
EYE35_RS18435	COG3046	protein related to deoxyribodipyrimidine photolyase
EYE35_RS18440	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
EYE35_RS18445	COG1262	PFAM Formylglycine-generating sulfatase enzyme
EYE35_RS18465	COG0702	epimerase
EYE35_RS18490	COG2223	nitrite transmembrane transporter activity
EYE35_RS18495	COG1349	DNA-binding transcription factor activity
EYE35_RS18525	COG4176	ABC-type proline glycine betaine transport system permease component
EYE35_RS18550	COG0400	carboxylic ester hydrolase activity
EYE35_RS18555	COG0346	lactoylglutathione lyase activity
EYE35_RS18575	COG0303	'Molybdopterin
EYE35_RS18590	COG3005	denitrification pathway
EYE35_RS18610	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EYE35_RS18615	COG0745	RESPONSE REGULATOR receiver
EYE35_RS18620	COG5002	protein histidine kinase activity
EYE35_RS18620	COG5000	phosphorelay sensor kinase activity
EYE35_RS18660	COG1028	Short-chain dehydrogenase reductase Sdr
EYE35_RS18675	COG3920	Histidine kinase
EYE35_RS18740	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EYE35_RS18745	COG0438	transferase activity, transferring glycosyl groups
EYE35_RS18750	COG0697	spore germination
EYE35_RS18760	COG2096	Adenosyltransferase
EYE35_RS18775	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EYE35_RS18775	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EYE35_RS18785	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
EYE35_RS18790	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EYE35_RS18790	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EYE35_RS18795	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
EYE35_RS18805	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
EYE35_RS18810	COG1250	3-hydroxyacyl-CoA dehydrogenase
EYE35_RS18830	COG1414	Transcriptional regulator
EYE35_RS18835	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
EYE35_RS18840	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
EYE35_RS18845	COG1028	Short-chain dehydrogenase reductase Sdr
EYE35_RS18850	COG3959	Transketolase, thiamine diphosphate binding domain
EYE35_RS18855	COG3958	Transketolase
EYE35_RS18865	COG2188	Transcriptional regulator
EYE35_RS18870	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
EYE35_RS18875	COG1070	Carbohydrate kinase
EYE35_RS18880	COG3842	ATPase activity
EYE35_RS18885	COG3842	ATPase activity
EYE35_RS18895	COG0395	ABC-type sugar transport system, permease component
EYE35_RS18910	COG0028	Belongs to the TPP enzyme family
EYE35_RS18915	COG1177	transmembrane transport
EYE35_RS18920	COG1176	ABC-type spermidine putrescine transport system, permease component I
EYE35_RS18925	COG3842	ATPase activity
EYE35_RS18935	COG2186	Transcriptional regulator
EYE35_RS18950	COG0604	alcohol dehydrogenase
EYE35_RS18990	COG4948	Mandelate Racemase Muconate Lactonizing
EYE35_RS18995	COG4948	Mandelate Racemase Muconate Lactonizing
EYE35_RS19000	COG1028	Short-chain dehydrogenase reductase Sdr
EYE35_RS19005	COG1063	alcohol dehydrogenase
EYE35_RS19010	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
EYE35_RS19020	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
EYE35_RS19025	COG0129	dihydroxy-acid dehydratase activity
EYE35_RS19035	COG0800	Aldolase
EYE35_RS19040	COG3734	2-keto-3-deoxy-galactonokinase
EYE35_RS19045	COG1809	phosphosulfolactate synthase activity
EYE35_RS19050	COG1053	succinate dehydrogenase
EYE35_RS19065	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EYE35_RS19095	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
EYE35_RS19120	COG1378	Sugar-specific transcriptional regulator TrmB
EYE35_RS19125	COG2855	membrane
EYE35_RS19130	COG1802	Transcriptional regulator
EYE35_RS19135	COG1595	DNA-templated transcription, initiation
EYE35_RS19180	COG1121	(ABC) transporter
EYE35_RS19200	COG3842	ATPase activity
EYE35_RS19205	COG0395	ABC-type sugar transport system, permease component
EYE35_RS19210	COG1175	transmembrane transport
EYE35_RS19220	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EYE35_RS19235	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EYE35_RS19255	COG1414	Transcriptional regulator
EYE35_RS19260	COG2376	Dihydroxyacetone kinase
EYE35_RS19265	COG1802	Transcriptional regulator
EYE35_RS19270	COG0626	cystathionine gamma-synthase activity
EYE35_RS19275	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EYE35_RS19280	COG4597	amino acid ABC transporter
EYE35_RS19285	COG0765	amino acid transport
EYE35_RS19290	COG1126	abc transporter atp-binding protein
EYE35_RS19300	COG2079	MmgE PrpD family protein
EYE35_RS19305	COG2079	MmgE PrpD family protein
EYE35_RS19325	COG2828	Protein conserved in bacteria
EYE35_RS19330	COG0583	DNA-binding transcription factor activity
EYE35_RS19335	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EYE35_RS19340	COG4948	Mandelate Racemase Muconate Lactonizing
EYE35_RS19345	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
EYE35_RS19355	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
EYE35_RS19360	COG2186	Transcriptional regulator
EYE35_RS19375	COG0523	cobalamin synthesis protein
EYE35_RS19390	COG1492	cobalamin metabolic process
EYE35_RS19395	COG1492	cobalamin metabolic process
EYE35_RS19405	COG0110	maltose O-acetyltransferase activity
EYE35_RS19420	COG1024	Enoyl-CoA hydratase
EYE35_RS19425	COG1024	Enoyl-CoA hydratase
EYE35_RS19440	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EYE35_RS19450	COG1063	alcohol dehydrogenase
EYE35_RS19455	COG0246	Mannitol dehydrogenase
EYE35_RS19460	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
EYE35_RS19465	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
EYE35_RS19465	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
EYE35_RS19470	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
EYE35_RS19475	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
EYE35_RS19480	COG4993	Dehydrogenase
EYE35_RS19725	COG2197	response regulator
EYE35_RS19735	COG1088	dTDP-glucose 4,6-dehydratase activity
EYE35_RS19760	COG0438	transferase activity, transferring glycosyl groups
EYE35_RS19770	COG0489	protein tyrosine kinase activity
EYE35_RS19785	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EYE35_RS19790	COG0673	inositol 2-dehydrogenase activity
EYE35_RS19815	COG1442	glycosyl transferase family 8
EYE35_RS19825	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EYE35_RS19830	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EYE35_RS19840	COG0523	cobalamin synthesis protein
EYE35_RS19880	COG2010	Cytochrome c
EYE35_RS19895	COG2249	NAD(P)H dehydrogenase (quinone) activity
EYE35_RS19925	COG1960	acyl-CoA dehydrogenase activity
EYE35_RS19930	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EYE35_RS19940	COG3246	L-lysine catabolic process to acetate
EYE35_RS19960	COG4774	siderophore transport
EYE35_RS19980	COG0438	transferase activity, transferring glycosyl groups
EYE35_RS20010	COG0438	transferase activity, transferring glycosyl groups
EYE35_RS20040	COG2197	response regulator
EYE35_RS20050	COG2197	response regulator
EYE35_RS20120	COG0489	protein tyrosine kinase activity
EYE35_RS20120	COG3206	protein involved in exopolysaccharide biosynthesis
EYE35_RS20125	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EYE35_RS20135	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EYE35_RS20200	COG1401	restriction endodeoxyribonuclease activity
EYE35_RS20240	COG1192	Involved in chromosome partitioning
EYE35_RS20270	COG0523	cobalamin synthesis protein
EYE35_RS20290	COG2358	TRAP transporter, solute receptor (TAXI family
EYE35_RS20305	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EYE35_RS20335	COG0765	amino acid transport
EYE35_RS20345	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EYE35_RS20350	COG1012	belongs to the aldehyde dehydrogenase family
EYE35_RS20355	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
EYE35_RS20370	COG1172	Belongs to the binding-protein-dependent transport system permease family
EYE35_RS20375	COG1172	Belongs to the binding-protein-dependent transport system permease family
EYE35_RS20380	COG1129	ABC transporter
EYE35_RS20390	COG1349	DNA-binding transcription factor activity
EYE35_RS20395	COG0625	glutathione transferase activity
EYE35_RS20410	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
EYE35_RS20420	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
EYE35_RS20475	COG2111	Na H antiporter
EYE35_RS20475	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
EYE35_RS20480	COG1006	Multisubunit Na H antiporter MnhC subunit
EYE35_RS20485	COG0651	ATP synthesis coupled electron transport
EYE35_RS20490	COG1863	multisubunit Na H antiporter MnhE subunit
EYE35_RS20495	COG2212	antiporter activity
EYE35_RS20505	COG0840	transmembrane signaling receptor activity
EYE35_RS20510	COG1252	NADH dehydrogenase
EYE35_RS20530	COG4214	carbohydrate transport
EYE35_RS20550	COG4208	sulfate ABC transporter
EYE35_RS20565	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
EYE35_RS20570	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EYE35_RS20585	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EYE35_RS20600	COG1172	Belongs to the binding-protein-dependent transport system permease family
EYE35_RS20645	COG1902	pentaerythritol trinitrate reductase activity
EYE35_RS20645	COG0446	pyridine nucleotide-disulphide oxidoreductase
EYE35_RS20670	COG3842	ATPase activity
EYE35_RS20675	COG1802	Transcriptional regulator
EYE35_RS20690	COG1175	transmembrane transport
EYE35_RS20720	COG2197	response regulator
EYE35_RS20750	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EYE35_RS20785	COG1442	glycosyl transferase family 8
EYE35_RS20925	COG1858	cytochrome C peroxidase
EYE35_RS21195	COG2189	Belongs to the N(4) N(6)-methyltransferase family
EYE35_RS21235	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
EYE35_RS21245	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
EYE35_RS21250	COG4181	ATPase activity
EYE35_RS21260	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EYE35_RS21265	COG1702	phosphate starvation-inducible protein PhoH
EYE35_RS21270	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
EYE35_RS21275	COG1253	flavin adenine dinucleotide binding
EYE35_RS21280	COG0815	Transfers the fatty acyl group on membrane lipoproteins
EYE35_RS21295	COG0220	tRNA (guanine-N7-)-methyltransferase activity
EYE35_RS21305	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
EYE35_RS21310	COG0539	negative regulation of cytoplasmic translation
EYE35_RS21335	COG0133	tryptophan synthase activity
EYE35_RS21410	COG2986	histidine ammonia-lyase
EYE35_RS21425	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
EYE35_RS21435	COG1121	(ABC) transporter
EYE35_RS21440	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EYE35_RS21445	COG0404	The glycine cleavage system catalyzes the degradation of glycine
EYE35_RS21465	COG0446	pyridine nucleotide-disulphide oxidoreductase
EYE35_RS21480	COG1079	Belongs to the binding-protein-dependent transport system permease family
EYE35_RS21485	COG4603	Belongs to the binding-protein-dependent transport system permease family
EYE35_RS21490	COG3845	ABC transporter
EYE35_RS21520	COG0124	histidyl-tRNA synthetase
EYE35_RS21525	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
EYE35_RS21530	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
EYE35_RS21585	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
EYE35_RS21615	COG0352	thiamine-phosphate diphosphorylase activity
EYE35_RS21635	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
EYE35_RS21670	COG1228	amidohydrolase
EYE35_RS21690	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
EYE35_RS21710	COG0356	it plays a direct role in the translocation of protons across the membrane
EYE35_RS21735	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EYE35_RS21810	COG1192	Involved in chromosome partitioning
EYE35_RS21830	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
EYE35_RS21835	COG1088	dTDP-glucose 4,6-dehydratase activity
EYE35_RS21840	COG1091	dTDP-4-dehydrorhamnose reductase activity
EYE35_RS21860	COG2877	3-deoxy-8-phosphooctulonate synthase activity
EYE35_RS21900	COG1522	sequence-specific DNA binding
EYE35_RS21905	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
EYE35_RS21910	COG4208	sulfate ABC transporter
EYE35_RS21920	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
EYE35_RS21940	COG1959	2 iron, 2 sulfur cluster binding
EYE35_RS21950	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EYE35_RS21960	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
EYE35_RS21965	COG4149	molybdate abc transporter
EYE35_RS21970	COG0725	ABC transporter, periplasmic molybdate-binding protein
EYE35_RS21990	COG2186	Transcriptional regulator
EYE35_RS22005	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EYE35_RS22015	COG5443	negative regulation of bacterial-type flagellum assembly
EYE35_RS22025	COG4608	Belongs to the ABC transporter superfamily
EYE35_RS22035	COG4948	Mandelate Racemase Muconate Lactonizing
EYE35_RS22045	COG3608	succinylglutamate desuccinylase aspartoacylase
EYE35_RS22050	COG4948	Mandelate Racemase Muconate Lactonizing
EYE35_RS22055	COG1028	Short-chain dehydrogenase reductase Sdr
EYE35_RS22075	COG0747	negative chemotaxis
EYE35_RS22080	COG1802	Transcriptional regulator
EYE35_RS22090	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EYE35_RS22100	COG0659	secondary active sulfate transmembrane transporter activity
EYE35_RS22105	COG0589	response to stress