locus-tag	class	description
LSP_RS00015	COG3944	biosynthesis protein
LSP_RS00020	COG0489	protein tyrosine kinase activity
LSP_RS00025	COG0438	transferase activity, transferring glycosyl groups
LSP_RS00030	COG0438	transferase activity, transferring glycosyl groups
LSP_RS00030	COG0297	glycogen (starch) synthase activity
LSP_RS00040	COG1216	Glycosyl transferase, family 2
LSP_RS00045	COG1692	metallophosphoesterase
LSP_RS00050	COG2359	stage V sporulation protein S
LSP_RS00055	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
LSP_RS00055	COG0674	pyruvate-flavodoxin oxidoreductase activity
LSP_RS00060	COG1013	pyruvate-flavodoxin oxidoreductase activity
LSP_RS00080	COG1176	ABC-type spermidine putrescine transport system, permease component I
LSP_RS00090	COG3842	ATPase activity
LSP_RS00095	COG1349	DNA-binding transcription factor activity
LSP_RS00100	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
LSP_RS00115	COG4550	Control of competence regulator ComK, YlbF/YmcA
LSP_RS00130	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
LSP_RS00135	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
LSP_RS00140	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
LSP_RS00155	COG1923	regulation of RNA biosynthetic process
LSP_RS00160	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LSP_RS00175	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
LSP_RS00180	COG2860	membrane
LSP_RS00185	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
LSP_RS00190	COG0789	Transcriptional regulator
LSP_RS00195	COG0174	glutamine synthetase
LSP_RS00205	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LSP_RS00210	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LSP_RS00215	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LSP_RS00230	COG3314	Sporulation integral membrane protein YlbJ
LSP_RS00240	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
LSP_RS00255	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
LSP_RS00260	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
LSP_RS00270	COG1388	LysM domain
LSP_RS00275	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
LSP_RS00285	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LSP_RS00305	COG4585	Histidine kinase
LSP_RS00330	COG3763	UPF0154 protein
LSP_RS00340	COG1473	amidohydrolase
LSP_RS00345	COG1854	S-ribosylhomocysteine lyase activity
LSP_RS00350	COG1073	alpha beta
LSP_RS00355	COG0183	Belongs to the thiolase family
LSP_RS00375	COG0667	Aldo Keto reductase
LSP_RS00390	COG0735	belongs to the Fur family
LSP_RS00395	COG4974	Belongs to the 'phage' integrase family
LSP_RS00405	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
LSP_RS00425	COG0697	spore germination
LSP_RS00430	COG0019	diaminopimelate decarboxylase activity
LSP_RS00440	COG1547	Domain of unknown function (DUF309)
LSP_RS00445	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
LSP_RS00450	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
LSP_RS00455	COG1686	Belongs to the peptidase S11 family
LSP_RS00460	COG1187	pseudouridine synthase activity
LSP_RS00465	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LSP_RS00470	COG1333	cytochrome c biogenesis protein
LSP_RS00475	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LSP_RS00480	COG0745	RESPONSE REGULATOR receiver
LSP_RS00485	COG5002	protein histidine kinase activity
LSP_RS00490	COG1595	DNA-templated transcription, initiation
LSP_RS00500	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
LSP_RS00505	COG0733	neurotransmitter:sodium symporter activity
LSP_RS00510	COG0174	glutamine synthetase
LSP_RS00520	COG3708	Transcriptional regulator
LSP_RS00520	COG2207	Transcriptional regulator
LSP_RS00550	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
LSP_RS00560	COG2076	Multidrug Resistance protein
LSP_RS00565	COG2076	Multidrug Resistance protein
LSP_RS00580	COG4175	Glycine betaine
LSP_RS00580	COG3448	diguanylate cyclase activity
LSP_RS00590	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LSP_RS00590	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LSP_RS00595	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LSP_RS00595	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LSP_RS00620	COG0402	S-adenosylhomocysteine deaminase activity
LSP_RS00625	COG0583	DNA-binding transcription factor activity
LSP_RS00650	COG1683	Conserved Protein
LSP_RS00670	COG5002	protein histidine kinase activity
LSP_RS00675	COG0745	RESPONSE REGULATOR receiver
LSP_RS00685	COG1131	(ABC) transporter
LSP_RS00710	COG2856	Zn peptidase
LSP_RS00815	COG0739	heme binding
LSP_RS00840	COG0583	DNA-binding transcription factor activity
LSP_RS00850	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
LSP_RS00865	COG1131	(ABC) transporter
LSP_RS00870	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
LSP_RS00880	COG3069	C4-dicarboxylate transmembrane transporter activity
LSP_RS00885	COG1802	Transcriptional regulator
LSP_RS00890	COG1063	alcohol dehydrogenase
LSP_RS00925	COG2207	Transcriptional regulator
LSP_RS00925	COG1917	Cupin 2, conserved barrel domain protein
LSP_RS00935	COG0662	Cupin 2, conserved barrel domain protein
LSP_RS00940	COG2314	TM2 domain
LSP_RS00970	COG0492	ferredoxin-NADP+ reductase activity
LSP_RS00980	COG1780	Probably involved in ribonucleotide reductase function
LSP_RS00985	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LSP_RS00990	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LSP_RS01015	COG2378	regulation of single-species biofilm formation
LSP_RS01020	COG2318	DinB family
LSP_RS01030	COG0667	Aldo Keto reductase
LSP_RS01035	COG0583	DNA-binding transcription factor activity
LSP_RS01055	COG0604	alcohol dehydrogenase
LSP_RS01070	COG0833	amino acid
LSP_RS01075	COG3739	integral membrane protein
LSP_RS01095	COG1686	Belongs to the peptidase S11 family
LSP_RS01110	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LSP_RS01120	COG0701	Predicted permease
LSP_RS01125	COG2207	Transcriptional regulator
LSP_RS01130	COG1028	Short-chain dehydrogenase reductase Sdr
LSP_RS01135	COG0840	transmembrane signaling receptor activity
LSP_RS01140	COG1744	ABC transporter substrate-binding protein PnrA-like
LSP_RS01155	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LSP_RS01165	COG3842	ATPase activity
LSP_RS01170	COG1840	ABC-type Fe3 transport system, periplasmic component
LSP_RS01175	COG1177	transmembrane transport
LSP_RS01180	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
LSP_RS01190	COG0501	Belongs to the peptidase M48B family
LSP_RS01195	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
LSP_RS01220	COG1131	(ABC) transporter
LSP_RS01240	COG3290	protein histidine kinase activity
LSP_RS01240	COG0840	transmembrane signaling receptor activity
LSP_RS01245	COG0488	(ABC) transporter
LSP_RS01255	COG0737	Belongs to the 5'-nucleotidase family
LSP_RS01265	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
LSP_RS01270	COG3639	organic phosphonate transmembrane transporter activity
LSP_RS01290	COG1585	Membrane protein implicated in regulation of membrane protease activity
LSP_RS01295	COG2268	Band 7 protein
LSP_RS01300	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LSP_RS01305	COG0840	transmembrane signaling receptor activity
LSP_RS01310	COG2814	Major facilitator Superfamily
LSP_RS01330	COG1141	Ferredoxin
LSP_RS01335	COG4955	Helix-turn-helix domain
LSP_RS01340	COG0514	ATP-dependent DNA helicase (RecQ)
LSP_RS01345	COG1388	LysM domain
LSP_RS01350	COG1408	metallophosphoesterase
LSP_RS01355	COG0492	ferredoxin-NADP+ reductase activity
LSP_RS01370	COG0252	asparaginase activity
LSP_RS01375	COG2339	peptidase activity
LSP_RS01380	COG3409	Peptidoglycan-binding domain 1 protein
LSP_RS01380	COG3773	Cell wall hydrolase
LSP_RS01390	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
LSP_RS01400	COG0539	negative regulation of cytoplasmic translation
LSP_RS01425	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
LSP_RS01460	COG0105	UTP biosynthetic process
LSP_RS01465	COG0183	Belongs to the thiolase family
LSP_RS01475	COG0318	PFAM AMP-dependent synthetase and ligase
LSP_RS01485	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
LSP_RS01500	COG4401	Chorismate mutase type I
LSP_RS01510	COG0287	Prephenate dehydrogenase
LSP_RS01515	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
LSP_RS01520	COG0457	Tetratricopeptide repeat
LSP_RS01525	COG5582	Belongs to the UPF0302 family
LSP_RS01535	COG0723	plastoquinol--plastocyanin reductase activity
LSP_RS01540	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
LSP_RS01550	COG4347	Protein of unknown function (DUF1405)
LSP_RS01555	COG2738	Putative neutral zinc metallopeptidase
LSP_RS01560	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
LSP_RS01565	COG1694	Mazg nucleotide pyrophosphohydrolase
LSP_RS01580	COG0438	transferase activity, transferring glycosyl groups
LSP_RS01620	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
LSP_RS01625	COG0737	Belongs to the 5'-nucleotidase family
LSP_RS01630	COG1199	ATP-dependent helicase activity
LSP_RS01630	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LSP_RS01640	COG2936	dipeptidyl-peptidase activity
LSP_RS01660	COG2169	Transcriptional regulator
LSP_RS01665	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
LSP_RS01670	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LSP_RS01675	COG2155	Conserved Protein
LSP_RS01685	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
LSP_RS01705	COG0493	'glutamate synthase
LSP_RS01725	COG0531	amino acid
LSP_RS01730	COG1113	amino acid transport
LSP_RS01760	COG2340	Cysteine-rich secretory protein family
LSP_RS01775	COG2720	vancomycin resistance protein
LSP_RS01785	COG0546	phosphoglycolate phosphatase activity
LSP_RS01800	COG0488	(ABC) transporter
LSP_RS01805	COG0307	riboflavin synthase, alpha
LSP_RS01845	COG1028	Short-chain dehydrogenase reductase Sdr
LSP_RS01850	COG4708	membrane
LSP_RS01865	COG0312	modulator of DNA gyrase
LSP_RS01875	COG1533	DNA photolyase activity
LSP_RS01880	COG2235	arginine
LSP_RS01885	COG1113	amino acid transport
LSP_RS01890	COG3403	YqcI/YcgG family
LSP_RS01900	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
LSP_RS01905	COG5002	protein histidine kinase activity
LSP_RS01915	COG1132	(ABC) transporter
LSP_RS01920	COG2508	Transcriptional regulator
LSP_RS01925	COG0666	response to abiotic stimulus
LSP_RS01935	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
LSP_RS01940	COG1304	FMN binding
LSP_RS01945	COG1953	Uracil, thiamine, allantoin
LSP_RS01950	COG0549	Belongs to the carbamate kinase family
LSP_RS01955	COG0590	tRNA wobble adenosine to inosine editing
LSP_RS01960	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LSP_RS01965	COG2807	transmembrane transport
LSP_RS01970	COG0583	DNA-binding transcription factor activity
LSP_RS01980	COG2132	Multicopper oxidase
LSP_RS01985	COG5001	Diguanylate cyclase
LSP_RS01985	COG5002	protein histidine kinase activity
LSP_RS02000	COG0017	Asparaginyl-tRNA synthetase
LSP_RS02005	COG3935	DnaD domain protein
LSP_RS02010	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
LSP_RS02020	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LSP_RS02020	COG4499	WXG100 protein secretion system (Wss), protein YukC
LSP_RS02025	COG3331	DNA recombination
LSP_RS02040	COG1111	helicase
LSP_RS02040	COG1205	dead DEAH box helicase
LSP_RS02050	COG3359	exonuclease
LSP_RS02070	COG0116	Belongs to the methyltransferase superfamily
LSP_RS02075	COG1199	ATP-dependent helicase activity
LSP_RS02090	COG3192	ethanolamine utilization protein
LSP_RS02095	COG4810	utilization protein
LSP_RS02100	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
LSP_RS02110	COG4303	Ethanolamine ammonia lyase large subunit
LSP_RS02115	COG4302	ethanolamine ammonia-lyase activity
LSP_RS02125	COG1012	belongs to the aldehyde dehydrogenase family
LSP_RS02125	COG1454	alcohol dehydrogenase
LSP_RS02135	COG4869	propanediol catabolic process
LSP_RS02140	COG4869	propanediol catabolic process
LSP_RS02145	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
LSP_RS02155	COG0039	L-malate dehydrogenase activity
LSP_RS02175	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
LSP_RS02180	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LSP_RS02185	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
LSP_RS02195	COG0444	Belongs to the ABC transporter superfamily
LSP_RS02200	COG4608	Belongs to the ABC transporter superfamily
LSP_RS02205	COG1414	Transcriptional regulator
LSP_RS02220	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LSP_RS02235	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
LSP_RS02240	COG1984	allophanate hydrolase subunit 2
LSP_RS02245	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
LSP_RS02250	COG0671	phosphoesterase, PA-phosphatase related
LSP_RS02270	COG0577	efflux transmembrane transporter activity
LSP_RS02275	COG1136	(ABC) transporter
LSP_RS02285	COG0745	RESPONSE REGULATOR receiver
LSP_RS02290	COG5002	protein histidine kinase activity
LSP_RS02295	COG0840	transmembrane signaling receptor activity
LSP_RS02300	COG2200	EAL domain
LSP_RS02315	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
LSP_RS02325	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LSP_RS02330	COG0281	malic enzyme
LSP_RS02335	COG0840	transmembrane signaling receptor activity
LSP_RS02350	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
LSP_RS02355	COG1671	Belongs to the UPF0178 family
LSP_RS02365	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
LSP_RS02380	COG0778	Nitroreductase
LSP_RS02385	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LSP_RS02390	COG1988	membrane-bound metal-dependent
LSP_RS02405	COG5146	pantothenate kinase activity
LSP_RS02420	COG0693	protein deglycase activity
LSP_RS02425	COG1846	Transcriptional regulator
LSP_RS02430	COG2814	Major facilitator Superfamily
LSP_RS02435	COG0791	NLP P60 protein
LSP_RS02445	COG2814	Major facilitator Superfamily
LSP_RS02450	COG4978	Transcriptional regulator
LSP_RS02450	COG0789	Transcriptional regulator
LSP_RS02455	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LSP_RS02460	COG0583	DNA-binding transcription factor activity
LSP_RS02465	COG1126	abc transporter atp-binding protein
LSP_RS02470	COG0765	amino acid transport
LSP_RS02475	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LSP_RS02480	COG0328	RNA-DNA hybrid ribonuclease activity
LSP_RS02490	COG1405	negative regulation of cell septum assembly
LSP_RS02490	COG3012	SEC-C Motif Domain Protein
LSP_RS02495	COG1164	Oligoendopeptidase f
LSP_RS02500	COG0783	Belongs to the Dps family
LSP_RS02515	COG0583	DNA-binding transcription factor activity
LSP_RS02525	COG1309	transcriptional regulator
LSP_RS02555	COG2759	Belongs to the formate--tetrahydrofolate ligase family
LSP_RS02585	COG1418	mRNA catabolic process
LSP_RS02590	COG0076	glutamate decarboxylase activity
LSP_RS02595	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LSP_RS02600	COG0488	(ABC) transporter
LSP_RS02605	COG1413	lyase activity
LSP_RS02610	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LSP_RS02615	COG0473	3-isopropylmalate dehydrogenase activity
LSP_RS02620	COG1028	Short-chain dehydrogenase reductase Sdr
LSP_RS02625	COG1012	belongs to the aldehyde dehydrogenase family
LSP_RS02630	COG0444	Belongs to the ABC transporter superfamily
LSP_RS02635	COG4608	Belongs to the ABC transporter superfamily
LSP_RS02655	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LSP_RS02665	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
LSP_RS02670	COG1846	Transcriptional regulator
LSP_RS02675	COG2153	protein acetylation
LSP_RS02685	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LSP_RS02690	COG0697	spore germination
LSP_RS02695	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
LSP_RS02700	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
LSP_RS02720	COG0583	DNA-binding transcription factor activity
LSP_RS02725	COG1647	Serine aminopeptidase, S33
LSP_RS02730	COG1114	Component of the transport system for branched-chain amino acids
LSP_RS02735	COG1028	Short-chain dehydrogenase reductase Sdr
LSP_RS02750	COG1309	transcriptional regulator
LSP_RS02770	COG4152	abc transporter atp-binding protein
LSP_RS02775	COG1668	transmembrane transport
LSP_RS02780	COG3853	Toxic anion resistance protein (TelA)
LSP_RS02790	COG2962	Rard protein
LSP_RS02795	COG1193	negative regulation of DNA recombination
LSP_RS02810	COG1556	Lactate utilization protein
LSP_RS02825	COG2186	Transcriptional regulator
LSP_RS02830	COG0785	Cytochrome C biogenesis protein
LSP_RS02835	COG2201	protein-glutamate methylesterase activity
LSP_RS02840	COG4846	Membrane protein involved in cytochrome C biogenesis
LSP_RS02865	COG1999	signal sequence binding
LSP_RS02890	COG0840	transmembrane signaling receptor activity
LSP_RS02895	COG1115	amino acid carrier protein
LSP_RS02900	COG1794	racemase activity, acting on amino acids and derivatives
LSP_RS02920	COG4166	transmembrane transport
LSP_RS02925	COG0601	transmembrane transport
LSP_RS02930	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LSP_RS02935	COG0444	Belongs to the ABC transporter superfamily
LSP_RS02940	COG4608	Belongs to the ABC transporter superfamily
LSP_RS02945	COG1619	proteins homologs of microcin C7 resistance protein MccF
LSP_RS02975	COG1388	LysM domain
LSP_RS02975	COG1705	Flagellar rod assembly protein muramidase FlgJ
LSP_RS02985	COG1125	glycine betaine transport
LSP_RS02985	COG0517	IMP dehydrogenase activity
LSP_RS02990	COG1174	glycine betaine transport
LSP_RS03000	COG3655	Transcriptional regulator
LSP_RS03005	COG2076	Multidrug Resistance protein
LSP_RS03010	COG2076	Multidrug Resistance protein
LSP_RS03020	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LSP_RS03030	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LSP_RS03040	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LSP_RS03045	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LSP_RS03050	COG0791	NLP P60 protein
LSP_RS03060	COG1309	transcriptional regulator
LSP_RS03065	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LSP_RS03075	COG1063	alcohol dehydrogenase
LSP_RS03085	COG5002	protein histidine kinase activity
LSP_RS03090	COG0745	RESPONSE REGULATOR receiver
LSP_RS03095	COG0666	response to abiotic stimulus
LSP_RS03105	COG2197	response regulator
LSP_RS03110	COG4585	Histidine kinase
LSP_RS03120	COG2226	methyltransferase
LSP_RS03135	COG1120	ATPase activity
LSP_RS03140	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LSP_RS03145	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LSP_RS03150	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LSP_RS03165	COG2814	Major facilitator Superfamily
LSP_RS03175	COG2837	iron assimilation
LSP_RS03180	COG0672	)-iron permease
LSP_RS03185	COG1357	PFAM Pentapeptide repeats (8 copies)
LSP_RS03190	COG2508	Transcriptional regulator
LSP_RS03205	COG0145	ligase activity
LSP_RS03220	COG1725	Transcriptional regulator
LSP_RS03225	COG1131	(ABC) transporter
LSP_RS03230	COG1131	(ABC) transporter
LSP_RS03235	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
LSP_RS03240	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LSP_RS03240	COG2190	(PTS) system
LSP_RS03240	COG1263	PTS System
LSP_RS03275	COG4326	sporulation control protein
LSP_RS03285	COG0785	Cytochrome C biogenesis protein
LSP_RS03290	COG2132	Multicopper oxidase
LSP_RS03295	COG1757	Na H antiporter
LSP_RS03300	COG1392	Phosphate transport regulator
LSP_RS03305	COG0306	phosphate transporter
LSP_RS03315	COG0745	RESPONSE REGULATOR receiver
LSP_RS03320	COG5002	protein histidine kinase activity
LSP_RS03350	COG1595	DNA-templated transcription, initiation
LSP_RS03360	COG3706	GGDEF domain
LSP_RS03375	COG3655	Transcriptional regulator
LSP_RS03390	COG1136	(ABC) transporter
LSP_RS03395	COG1595	DNA-templated transcription, initiation
LSP_RS03405	COG1268	BioY protein
LSP_RS03410	COG1574	metal-dependent hydrolase with the TIM-barrel fold
LSP_RS03420	COG0584	glycerophosphoryl diester phosphodiesterase
LSP_RS03435	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LSP_RS03450	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LSP_RS03465	COG3842	ATPase activity
LSP_RS03475	COG2211	Major facilitator Superfamily
LSP_RS03480	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LSP_RS03485	COG0456	acetyltransferase
LSP_RS03565	COG1694	Mazg nucleotide pyrophosphohydrolase
LSP_RS03585	COG2814	Major facilitator Superfamily
LSP_RS03590	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LSP_RS03610	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
LSP_RS03645	COG1028	Short-chain dehydrogenase reductase Sdr
LSP_RS03670	COG1472	Belongs to the glycosyl hydrolase 3 family
LSP_RS03680	COG0813	purine-nucleoside phosphorylase activity
LSP_RS03685	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LSP_RS03710	COG1309	transcriptional regulator
LSP_RS03720	COG0527	aspartate kinase activity
LSP_RS03735	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
LSP_RS03740	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LSP_RS03755	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
LSP_RS03785	COG1132	(ABC) transporter
LSP_RS03790	COG1132	(ABC) transporter
LSP_RS03800	COG0596	Alpha beta hydrolase
LSP_RS03805	COG0745	RESPONSE REGULATOR receiver
LSP_RS03810	COG0642	Histidine kinase
LSP_RS03845	COG1647	Serine aminopeptidase, S33
LSP_RS03850	COG0346	lactoylglutathione lyase activity
LSP_RS03860	COG2388	GCN5-related N-acetyl-transferase
LSP_RS03870	COG0840	transmembrane signaling receptor activity
LSP_RS03895	COG2226	methyltransferase
LSP_RS03900	COG2818	Glycosylase
LSP_RS03935	COG0702	epimerase
LSP_RS03985	COG4122	O-methyltransferase activity
LSP_RS03990	COG1335	isochorismatase
LSP_RS03995	COG3708	Transcriptional regulator
LSP_RS03995	COG2207	Transcriptional regulator
LSP_RS04000	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LSP_RS04105	COG1028	Short-chain dehydrogenase reductase Sdr
LSP_RS04110	COG2318	DinB family
LSP_RS04120	COG0697	spore germination
LSP_RS04130	COG0385	Bile acid
LSP_RS04145	COG1280	lysine exporter protein (LysE YggA)
LSP_RS04170	COG4716	Myosin-crossreactive antigen
LSP_RS04190	COG0546	phosphoglycolate phosphatase activity
LSP_RS04220	COG1028	Short-chain dehydrogenase reductase Sdr
LSP_RS04235	COG0202	RNA polymerase activity
LSP_RS04295	COG1361	Conserved repeat domain
LSP_RS04340	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LSP_RS04345	COG1309	transcriptional regulator
LSP_RS04350	COG0477	Major facilitator Superfamily
LSP_RS04355	COG0697	spore germination
LSP_RS04360	COG0583	DNA-binding transcription factor activity
LSP_RS04370	COG5002	protein histidine kinase activity
LSP_RS04375	COG0745	RESPONSE REGULATOR receiver
LSP_RS04385	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
LSP_RS04385	COG2755	lipolytic protein G-D-S-L family
LSP_RS04395	COG1316	TRANSCRIPTIONal
LSP_RS04405	COG1329	Transcriptional regulator
LSP_RS04410	COG1278	Cold shock
LSP_RS04415	COG0384	phenazine biosynthesis protein PhzF
LSP_RS04430	COG1595	DNA-templated transcription, initiation
LSP_RS04440	COG2207	Transcriptional regulator
LSP_RS04440	COG1917	Cupin 2, conserved barrel domain protein
LSP_RS04445	COG2972	Histidine kinase
LSP_RS04445	COG0745	RESPONSE REGULATOR receiver
LSP_RS04450	COG3279	Response regulator of the LytR AlgR family
LSP_RS04470	COG4974	Belongs to the 'phage' integrase family
LSP_RS04605	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LSP_RS04635	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LSP_RS04640	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LSP_RS04645	COG5002	protein histidine kinase activity
LSP_RS04645	COG3850	Histidine kinase
LSP_RS04650	COG0745	RESPONSE REGULATOR receiver
LSP_RS04725	COG2805	Type II/IV secretion system protein
LSP_RS04750	COG3693	PFAM glycoside hydrolase, family 10
LSP_RS04785	COG0791	NLP P60 protein
LSP_RS04785	COG0741	lytic transglycosylase activity
LSP_RS04840	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LSP_RS04885	COG2801	Transposase and inactivated derivatives
LSP_RS04900	COG0823	Involved in the tonB-independent uptake of proteins
LSP_RS04925	COG0745	RESPONSE REGULATOR receiver
LSP_RS04930	COG5002	protein histidine kinase activity
LSP_RS04940	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
LSP_RS04945	COG0569	domain protein
LSP_RS04950	COG3290	protein histidine kinase activity
LSP_RS04950	COG0840	transmembrane signaling receptor activity
LSP_RS04985	COG3290	protein histidine kinase activity
LSP_RS04985	COG0840	transmembrane signaling receptor activity
LSP_RS05005	COG2112	serine threonine protein kinase
LSP_RS05025	COG0697	spore germination
LSP_RS05040	COG1733	regulation of RNA biosynthetic process
LSP_RS05075	COG2323	membrane
LSP_RS05080	COG4978	Transcriptional regulator
LSP_RS05080	COG0789	Transcriptional regulator
LSP_RS05125	COG2808	Putative FMN-binding domain
LSP_RS05150	COG1619	proteins homologs of microcin C7 resistance protein MccF
LSP_RS05185	COG2226	methyltransferase
LSP_RS05205	COG0454	-acetyltransferase
LSP_RS05230	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
LSP_RS05270	COG2226	methyltransferase
LSP_RS05280	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LSP_RS05295	COG2197	response regulator
LSP_RS05300	COG4585	Histidine kinase
LSP_RS05325	COG1959	2 iron, 2 sulfur cluster binding
LSP_RS05330	COG2910	NAD(P)H-binding
LSP_RS05335	COG1027	Aspartate ammonia-lyase
LSP_RS05340	COG0840	transmembrane signaling receptor activity
LSP_RS05385	COG0601	transmembrane transport
LSP_RS05400	COG1124	(ABC) transporter
LSP_RS05445	COG4946	Tricorn protease homolog
LSP_RS05445	COG0823	Involved in the tonB-independent uptake of proteins
LSP_RS05445	COG1506	peptidase
LSP_RS05450	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
LSP_RS05455	COG0657	acetylesterase activity
LSP_RS05475	COG1272	protein, Hemolysin III
LSP_RS05480	COG1307	EDD domain protein, DegV family
LSP_RS05485	COG2755	lipolytic protein G-D-S-L family
LSP_RS05505	COG0840	transmembrane signaling receptor activity
LSP_RS05505	COG5278	phosphoserine phosphatase activity
LSP_RS05515	COG0813	purine-nucleoside phosphorylase activity
LSP_RS05595	COG0534	Mate efflux family protein
LSP_RS05610	COG0494	nUDIX hydrolase
LSP_RS05625	COG0745	RESPONSE REGULATOR receiver
LSP_RS05625	COG2972	Histidine kinase
LSP_RS05635	COG1522	sequence-specific DNA binding
LSP_RS05640	COG0640	Transcriptional regulator
LSP_RS05645	COG0346	lactoylglutathione lyase activity
LSP_RS05665	COG1280	lysine exporter protein (LysE YggA)
LSP_RS05670	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LSP_RS05700	COG0793	Belongs to the peptidase S41A family
LSP_RS05700	COG3409	Peptidoglycan-binding domain 1 protein
LSP_RS05710	COG2340	Cysteine-rich secretory protein family
LSP_RS05715	COG0697	spore germination
LSP_RS05730	COG0534	Mate efflux family protein
LSP_RS05735	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
LSP_RS05745	COG5001	Diguanylate cyclase
LSP_RS05750	COG0745	RESPONSE REGULATOR receiver
LSP_RS05755	COG5002	protein histidine kinase activity
LSP_RS05760	COG0567	Dehydrogenase, E1 component
LSP_RS05765	COG0508	dehydrogenase complex catalyzes the overall conversion of
LSP_RS05775	COG0765	amino acid transport
LSP_RS05780	COG1126	abc transporter atp-binding protein
LSP_RS05795	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
LSP_RS05805	COG1254	Belongs to the acylphosphatase family
LSP_RS05820	COG1278	Cold shock
LSP_RS05845	COG2318	DinB family
LSP_RS05855	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LSP_RS05865	COG0488	(ABC) transporter
LSP_RS05880	COG1819	glycosyl
LSP_RS05895	COG0477	Major facilitator Superfamily
LSP_RS05920	COG2081	HI0933 family
LSP_RS05930	COG0640	Transcriptional regulator
LSP_RS05935	COG0018	arginyl-trna synthetase
LSP_RS05940	COG2807	transmembrane transport
LSP_RS05950	COG0514	ATP-dependent DNA helicase (RecQ)
LSP_RS05955	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LSP_RS05965	COG0628	permease
LSP_RS05970	COG0662	Cupin 2, conserved barrel domain protein
LSP_RS05975	COG0436	Aminotransferase
LSP_RS05985	COG1024	Enoyl-CoA hydratase
LSP_RS05995	COG1305	Transglutaminase-like
LSP_RS06005	COG2308	Evidence 4 Homologs of previously reported genes of
LSP_RS06015	COG4974	Belongs to the 'phage' integrase family
LSP_RS06040	COG3300	MHYT domain
LSP_RS06040	COG5001	Diguanylate cyclase
LSP_RS06045	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
LSP_RS06050	COG1011	Hydrolase
LSP_RS06055	COG0494	nUDIX hydrolase
LSP_RS06090	COG0814	amino acid
LSP_RS06105	COG1705	Flagellar rod assembly protein muramidase FlgJ
LSP_RS06110	COG0745	RESPONSE REGULATOR receiver
LSP_RS06115	COG5002	protein histidine kinase activity
LSP_RS06115	COG3850	Histidine kinase
LSP_RS06120	COG0384	phenazine biosynthesis protein PhzF
LSP_RS06130	COG1396	sequence-specific DNA binding
LSP_RS06145	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LSP_RS06155	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LSP_RS06165	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LSP_RS06180	COG0488	(ABC) transporter
LSP_RS06185	COG2814	Major facilitator Superfamily
LSP_RS06200	COG2814	Major facilitator Superfamily
LSP_RS06205	COG0791	NLP P60 protein
LSP_RS06205	COG1388	LysM domain
LSP_RS06205	COG3103	Sh3 type 3 domain protein
LSP_RS06210	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LSP_RS06225	COG2508	Transcriptional regulator
LSP_RS06230	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LSP_RS06235	COG3257	ureidoglycine aminohydrolase activity
LSP_RS06240	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
LSP_RS06245	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
LSP_RS06250	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
LSP_RS06305	COG0640	Transcriptional regulator
LSP_RS06310	COG0798	PFAM Bile acid sodium symporter
LSP_RS06320	COG0492	ferredoxin-NADP+ reductase activity
LSP_RS06330	COG1309	transcriptional regulator
LSP_RS06335	COG3320	Male sterility
LSP_RS06335	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LSP_RS06345	COG0778	Nitroreductase
LSP_RS06350	COG1733	regulation of RNA biosynthetic process
LSP_RS06355	COG2249	NAD(P)H dehydrogenase (quinone) activity
LSP_RS06360	COG1028	Short-chain dehydrogenase reductase Sdr
LSP_RS06375	COG0825	malonyl-CoA metabolic process
LSP_RS06390	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LSP_RS06395	COG2169	Transcriptional regulator
LSP_RS06405	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
LSP_RS06410	COG0583	DNA-binding transcription factor activity
LSP_RS06415	COG0384	phenazine biosynthesis protein PhzF
LSP_RS06425	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
LSP_RS06425	COG0456	acetyltransferase
LSP_RS06440	COG2205	protein histidine kinase activity
LSP_RS06445	COG0745	RESPONSE REGULATOR receiver
LSP_RS06455	COG1131	(ABC) transporter
LSP_RS06475	COG1131	(ABC) transporter
LSP_RS06495	COG1620	l-lactate permease
LSP_RS06505	COG1028	Short-chain dehydrogenase reductase Sdr
LSP_RS06520	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
LSP_RS06525	COG1846	Transcriptional regulator
LSP_RS06550	COG0488	(ABC) transporter
LSP_RS06555	COG1082	Xylose isomerase domain protein TIM barrel
LSP_RS06585	COG0456	acetyltransferase
LSP_RS06590	COG2364	Membrane
LSP_RS06595	COG1024	Enoyl-CoA hydratase
LSP_RS06600	COG1024	Enoyl-CoA hydratase
LSP_RS06605	COG1960	acyl-CoA dehydrogenase activity
LSP_RS06610	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
LSP_RS06615	COG2079	MmgE PrpD family protein
LSP_RS06620	COG0372	Belongs to the citrate synthase family
LSP_RS06630	COG1124	(ABC) transporter
LSP_RS06640	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LSP_RS06645	COG0601	transmembrane transport
LSP_RS06650	COG0747	negative chemotaxis
LSP_RS06655	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
LSP_RS06675	COG1028	Short-chain dehydrogenase reductase Sdr
LSP_RS06680	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LSP_RS06690	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
LSP_RS06695	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
LSP_RS06750	COG1113	amino acid transport
LSP_RS06780	COG0604	alcohol dehydrogenase
LSP_RS06785	COG0640	Transcriptional regulator
LSP_RS06790	COG1999	signal sequence binding
LSP_RS06800	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LSP_RS06810	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LSP_RS06815	COG0084	hydrolase, TatD family'
LSP_RS06825	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LSP_RS06835	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LSP_RS06840	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
LSP_RS06845	COG0187	DNA topoisomerase II activity
LSP_RS06850	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
LSP_RS06855	COG4841	protein insertion into membrane
LSP_RS06860	COG0697	spore germination
LSP_RS06885	COG0322	excinuclease ABC activity
LSP_RS06895	COG1378	Sugar-specific transcriptional regulator TrmB
LSP_RS06900	COG0730	response to heat
LSP_RS06905	COG4145	pantothenate transmembrane transporter activity
LSP_RS06970	COG2267	carboxylic ester hydrolase activity
LSP_RS06990	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LSP_RS06995	COG2814	Major facilitator Superfamily
LSP_RS07000	COG2140	Oxalate decarboxylase
LSP_RS07005	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LSP_RS07010	COG1279	arginine transmembrane transporter activity
LSP_RS07030	COG1522	sequence-specific DNA binding
LSP_RS07040	COG3693	PFAM glycoside hydrolase, family 10
LSP_RS07045	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
LSP_RS07070	COG4824	toxin secretion phage lysis holin
LSP_RS07095	COG0456	acetyltransferase
LSP_RS07135	COG0596	Alpha beta hydrolase
LSP_RS07155	COG2323	membrane
LSP_RS07175	COG0456	acetyltransferase
LSP_RS07190	COG3285	dna ligase
LSP_RS07190	COG1793	dna ligase
LSP_RS07195	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
LSP_RS07200	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
LSP_RS07205	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LSP_RS07215	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
LSP_RS07220	COG2378	regulation of single-species biofilm formation
LSP_RS07250	COG0720	synthase
LSP_RS07260	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
LSP_RS07270	COG3590	peptidase
LSP_RS07345	COG2200	EAL domain
LSP_RS07360	COG2363	Small membrane protein
LSP_RS07365	COG0824	Thioesterase
LSP_RS07375	COG2910	NAD(P)H-binding
LSP_RS07380	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
LSP_RS07385	COG1959	2 iron, 2 sulfur cluster binding
LSP_RS07410	COG0346	lactoylglutathione lyase activity
LSP_RS07435	COG4974	Belongs to the 'phage' integrase family
LSP_RS07445	COG1073	alpha beta
LSP_RS07465	COG5484	DNA packaging
LSP_RS07495	COG3397	chitin binding
LSP_RS07540	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LSP_RS07550	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LSP_RS07580	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
LSP_RS07610	COG1595	DNA-templated transcription, initiation
LSP_RS07635	COG4335	DNA alkylation repair
LSP_RS07640	COG2378	regulation of single-species biofilm formation
LSP_RS07660	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LSP_RS07670	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LSP_RS07675	COG1959	2 iron, 2 sulfur cluster binding
LSP_RS07680	COG0778	Nitroreductase
LSP_RS07685	COG1764	response to oxidative stress
LSP_RS07695	COG4978	Transcriptional regulator
LSP_RS07695	COG0789	Transcriptional regulator
LSP_RS07700	COG1811	Na channel or pump
LSP_RS07705	COG0739	heme binding
LSP_RS07745	COG2226	methyltransferase
LSP_RS07755	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
LSP_RS07775	COG2207	Transcriptional regulator
LSP_RS07790	COG0596	Alpha beta hydrolase
LSP_RS07815	COG1028	Short-chain dehydrogenase reductase Sdr
LSP_RS07820	COG1960	acyl-CoA dehydrogenase activity
LSP_RS07825	COG0583	DNA-binding transcription factor activity
LSP_RS07835	COG0786	glutamate:sodium symporter activity
LSP_RS07840	COG0726	polysaccharide deacetylase
LSP_RS07845	COG0346	lactoylglutathione lyase activity
LSP_RS07855	COG1686	Belongs to the peptidase S11 family
LSP_RS07880	COG0464	growth
LSP_RS07890	COG0393	Putative heavy-metal-binding
LSP_RS08050	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LSP_RS08080	COG2814	Major facilitator Superfamily
LSP_RS08090	COG0681	Belongs to the peptidase S26 family
LSP_RS08105	COG0006	proline dipeptidase activity
LSP_RS08115	COG1414	Transcriptional regulator
LSP_RS08125	COG1028	Short-chain dehydrogenase reductase Sdr
LSP_RS08140	COG1132	(ABC) transporter
LSP_RS08145	COG1132	(ABC) transporter
LSP_RS08155	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
LSP_RS08160	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
LSP_RS08175	COG1509	lysine 2,3-aminomutase activity
LSP_RS08200	COG0300	oxidoreductase activity
LSP_RS08200	COG3321	synthase
LSP_RS08200	COG4221	oxidoreductase activity
LSP_RS08200	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LSP_RS08220	COG2860	membrane
LSP_RS08230	COG1910	domain protein
LSP_RS08235	COG0725	ABC transporter, periplasmic molybdate-binding protein
LSP_RS08240	COG4149	molybdate abc transporter
LSP_RS08245	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
LSP_RS08250	COG0314	molybdopterin synthase activity
LSP_RS08255	COG1763	Mo-molybdopterin cofactor biosynthetic process
LSP_RS08260	COG0303	'Molybdopterin
LSP_RS08265	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
LSP_RS08270	COG0521	Mo-molybdopterin cofactor biosynthetic process
LSP_RS08290	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
LSP_RS08295	COG5609	conserved protein (DUF2294)
LSP_RS08300	COG3383	formate dehydrogenase (NAD+) activity
LSP_RS08305	COG2427	Protein of unknown function (DUF1641)
LSP_RS08310	COG0489	protein tyrosine kinase activity
LSP_RS08325	COG3196	Protein conserved in bacteria
LSP_RS08330	COG2329	Antibiotic biosynthesis monooxygenase
LSP_RS08335	COG0640	Transcriptional regulator
LSP_RS08350	COG5002	protein histidine kinase activity
LSP_RS08355	COG0745	RESPONSE REGULATOR receiver
LSP_RS08370	COG0477	Major facilitator Superfamily
LSP_RS08375	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LSP_RS08375	COG0425	Belongs to the sulfur carrier protein TusA family
LSP_RS08385	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LSP_RS08390	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LSP_RS08390	COG1321	iron dependent repressor
LSP_RS08395	COG1121	(ABC) transporter
LSP_RS08400	COG0803	Belongs to the bacterial solute-binding protein 9 family
LSP_RS08410	COG1028	Short-chain dehydrogenase reductase Sdr
LSP_RS08415	COG3693	PFAM glycoside hydrolase, family 10
LSP_RS08420	COG0583	DNA-binding transcription factor activity
LSP_RS08425	COG0655	NAD(P)H dehydrogenase (quinone) activity
LSP_RS08435	COG3420	alginic acid biosynthetic process
LSP_RS08450	COG3871	stress protein (general stress protein 26)
LSP_RS08455	COG2364	Membrane
LSP_RS08465	COG1011	Hydrolase
LSP_RS08470	COG0535	radical SAM domain protein
LSP_RS08475	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LSP_RS08490	COG1595	DNA-templated transcription, initiation
LSP_RS08515	COG1132	(ABC) transporter
LSP_RS08520	COG0861	Integral membrane protein TerC family
LSP_RS08540	COG1454	alcohol dehydrogenase
LSP_RS08550	COG1012	belongs to the aldehyde dehydrogenase family
LSP_RS08560	COG1690	Belongs to the RtcB family
LSP_RS08570	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LSP_RS08575	COG0066	3-isopropylmalate dehydratase activity
LSP_RS08600	COG0440	acetolactate synthase activity
LSP_RS08605	COG0028	Belongs to the TPP enzyme family
LSP_RS08610	COG0129	dihydroxy-acid dehydratase activity
LSP_RS08640	COG0626	cystathionine gamma-synthase activity
LSP_RS08645	COG0626	cystathionine gamma-synthase activity
LSP_RS08670	COG1473	amidohydrolase
LSP_RS08680	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LSP_RS08695	COG0165	Argininosuccinate lyase
LSP_RS08700	COG0137	argininosuccinate synthase activity
LSP_RS08710	COG0789	Transcriptional regulator
LSP_RS08715	COG0300	oxidoreductase activity
LSP_RS08720	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LSP_RS08725	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
LSP_RS08730	COG1902	pentaerythritol trinitrate reductase activity
LSP_RS08735	COG4844	belongs to the
LSP_RS08740	COG0583	DNA-binding transcription factor activity
LSP_RS08750	COG0431	NADPH-dependent FMN reductase
LSP_RS08755	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LSP_RS08760	COG0346	lactoylglutathione lyase activity
LSP_RS08780	COG1234	tRNA 3'-trailer cleavage
LSP_RS08785	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
LSP_RS08790	COG1492	cobalamin metabolic process
LSP_RS08795	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
LSP_RS08810	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LSP_RS08810	COG1648	precorrin-2 dehydrogenase activity
LSP_RS08840	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
LSP_RS08870	COG0310	cobalt ion transport
LSP_RS08885	COG1122	ATPase activity
LSP_RS08890	COG1404	Belongs to the peptidase S8 family
LSP_RS08895	COG0456	acetyltransferase
LSP_RS08910	COG1086	Polysaccharide biosynthesis protein
LSP_RS08925	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LSP_RS08940	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LSP_RS08945	COG0823	Involved in the tonB-independent uptake of proteins
LSP_RS08945	COG1506	peptidase
LSP_RS08945	COG4946	Tricorn protease homolog
LSP_RS08950	COG1473	amidohydrolase
LSP_RS08960	COG4948	Mandelate Racemase Muconate Lactonizing
LSP_RS08965	COG4608	Belongs to the ABC transporter superfamily
LSP_RS08970	COG0444	Belongs to the ABC transporter superfamily
LSP_RS08975	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LSP_RS08995	COG3048	D-serine ammonia-lyase activity
LSP_RS09005	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LSP_RS09010	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LSP_RS09015	COG1396	sequence-specific DNA binding
LSP_RS09055	COG2207	Transcriptional regulator
LSP_RS09055	COG1917	Cupin 2, conserved barrel domain protein
LSP_RS09060	COG0697	spore germination
LSP_RS09070	COG1280	lysine exporter protein (LysE YggA)
LSP_RS09080	COG0840	transmembrane signaling receptor activity
LSP_RS09105	COG2195	Cleaves the N-terminal amino acid of tripeptides
LSP_RS09120	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LSP_RS09125	COG0346	lactoylglutathione lyase activity
LSP_RS09130	COG4129	membrane
LSP_RS09140	COG1703	isobutyryl-CoA mutase activity
LSP_RS09145	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LSP_RS09145	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LSP_RS09155	COG0508	dehydrogenase complex catalyzes the overall conversion of
LSP_RS09160	COG0022	dehydrogenase e1 component
LSP_RS09165	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
LSP_RS09170	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LSP_RS09175	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
LSP_RS09185	COG0584	glycerophosphoryl diester phosphodiesterase
LSP_RS09205	COG0750	zinc metalloprotease
LSP_RS09210	COG0497	DNA recombination
LSP_RS09215	COG1438	arginine binding
LSP_RS09220	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
LSP_RS09230	COG0142	geranyltranstransferase activity
LSP_RS09265	COG4978	Transcriptional regulator
LSP_RS09265	COG0789	Transcriptional regulator
LSP_RS09270	COG2814	Major facilitator Superfamily
LSP_RS09275	COG1302	Protein conserved in bacteria
LSP_RS09285	COG1247	-acetyltransferase
LSP_RS09290	COG0439	Biotin carboxylase
LSP_RS09295	COG0511	ligase activity, forming carbon-carbon bonds
LSP_RS09325	COG2070	2-Nitropropane dioxygenase
LSP_RS09335	COG0006	proline dipeptidase activity
LSP_RS09340	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
LSP_RS09350	COG3872	metal-dependent enzyme
LSP_RS09360	COG1476	TRANSCRIPTIONal
LSP_RS09375	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LSP_RS09385	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LSP_RS09390	COG1113	amino acid transport
LSP_RS09395	COG2066	Belongs to the glutaminase family
LSP_RS09400	COG1473	amidohydrolase
LSP_RS09405	COG2271	Major facilitator Superfamily
LSP_RS09420	COG4585	Histidine kinase
LSP_RS09435	COG1397	ADP-ribosylglycohydrolase
LSP_RS09590	COG0484	heat shock protein binding
LSP_RS09605	COG0515	serine threonine protein kinase
LSP_RS09605	COG2815	serine threonine protein kinase
LSP_RS09625	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
LSP_RS09650	COG4537	Required for transformation and DNA binding
LSP_RS09655	COG1459	type II secretion system
LSP_RS09660	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LSP_RS09675	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LSP_RS09685	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
LSP_RS09690	COG1368	sulfuric ester hydrolase activity
LSP_RS09700	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
LSP_RS09705	COG0267	Belongs to the bacterial ribosomal protein bL33 family
LSP_RS09720	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
LSP_RS09720	COG0512	Glutamine amidotransferase of anthranilate synthase
LSP_RS09725	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
LSP_RS09730	COG0668	transmembrane transport
LSP_RS09740	COG0704	Plays a role in the regulation of phosphate uptake
LSP_RS09745	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
LSP_RS09750	COG0581	inorganic phosphate transmembrane transporter activity
LSP_RS09755	COG0573	inorganic phosphate transmembrane transporter activity
LSP_RS09760	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
LSP_RS09770	COG0768	penicillin binding
LSP_RS09780	COG2839	Protein conserved in bacteria
LSP_RS09785	COG1283	sodium-dependent phosphate transmembrane transporter activity
LSP_RS09805	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
LSP_RS09815	COG0789	Transcriptional regulator
LSP_RS09820	COG1253	flavin adenine dinucleotide binding
LSP_RS09835	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
LSP_RS09860	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LSP_RS09885	COG1215	transferase activity, transferring glycosyl groups
LSP_RS09900	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
LSP_RS09905	COG1335	isochorismatase
LSP_RS09930	COG0735	belongs to the Fur family
LSP_RS09935	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LSP_RS09940	COG1121	(ABC) transporter
LSP_RS09955	COG0513	Belongs to the DEAD box helicase family
LSP_RS09960	COG1063	alcohol dehydrogenase
LSP_RS09965	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
LSP_RS09970	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
LSP_RS09975	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
LSP_RS09980	COG2205	protein histidine kinase activity
LSP_RS09985	COG0745	RESPONSE REGULATOR receiver
LSP_RS10005	COG3290	protein histidine kinase activity
LSP_RS10010	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
LSP_RS10015	COG1301	dicarboxylic acid transport
LSP_RS10055	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
LSP_RS10060	COG2384	SAM-dependent methyltransferase
LSP_RS10075	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LSP_RS10080	COG0358	DNA primase activity
LSP_RS10090	COG0517	IMP dehydrogenase activity
LSP_RS10120	COG1381	Involved in DNA repair and RecF pathway recombination
LSP_RS10135	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
LSP_RS10145	COG1480	7TM receptor with intracellular HD hydrolase
LSP_RS10150	COG1702	phosphate starvation-inducible protein PhoH
LSP_RS10175	COG1030	water channel activity
LSP_RS10185	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
LSP_RS10190	COG0569	domain protein
LSP_RS10195	COG3546	catalase activity
LSP_RS10215	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LSP_RS10235	COG1385	rRNA (uridine-N3-)-methyltransferase activity
LSP_RS10240	COG2264	protein methyltransferase activity
LSP_RS10265	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LSP_RS10280	COG2404	hydrolase activity, acting on ester bonds
LSP_RS10285	COG0726	polysaccharide deacetylase
LSP_RS10295	COG0840	transmembrane signaling receptor activity
LSP_RS10340	COG2207	Transcriptional regulator
LSP_RS10340	COG0662	Cupin 2, conserved barrel domain protein
LSP_RS10410	COG5492	domain, Protein
LSP_RS10460	COG0481	GTPase activity
LSP_RS10465	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
LSP_RS10465	COG2755	lipolytic protein G-D-S-L family
LSP_RS10475	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
LSP_RS10485	COG1466	dna polymerase III delta subunit
LSP_RS10495	COG2333	competence protein COMEC
LSP_RS10495	COG0658	competence protein
LSP_RS10500	COG2131	deaminase
LSP_RS10505	COG1596	polysaccharide export
LSP_RS10505	COG1555	photosystem II stabilization
LSP_RS10510	COG2226	methyltransferase
LSP_RS10515	COG0799	negative regulation of ribosome biogenesis
LSP_RS10520	COG1713	HD superfamily hydrolase involved in NAD metabolism
LSP_RS10525	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
LSP_RS10530	COG1534	Rna-binding protein
LSP_RS10540	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
LSP_RS10545	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
LSP_RS10550	COG0688	phosphatidylethanolamine metabolic process
LSP_RS10555	COG1183	phosphatidylcholine synthase activity
LSP_RS10580	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LSP_RS10585	COG0572	uridine kinase
LSP_RS10590	COG0826	peptidase U32
LSP_RS10595	COG0826	peptidase U32
LSP_RS10600	COG4122	O-methyltransferase activity
LSP_RS10605	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
LSP_RS10610	COG3906	Belongs to the UPF0473 family
LSP_RS10615	COG3906	Belongs to the UPF0473 family
LSP_RS10620	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
LSP_RS10625	COG4472	Bacterial protein of unknown function (DUF965)
LSP_RS10640	COG2368	4-hydroxyphenylacetate
LSP_RS10645	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LSP_RS10660	COG2357	RelA SpoT domain protein
LSP_RS10665	COG2814	Major facilitator Superfamily
LSP_RS10680	COG1104	cysteine desulfurase activity
LSP_RS10685	COG1959	2 iron, 2 sulfur cluster binding
LSP_RS10690	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
LSP_RS10705	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
LSP_RS10720	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LSP_RS10725	COG1447	Phosphotransferase system cellobiose-specific component IIA
LSP_RS10750	COG2188	Transcriptional regulator
LSP_RS10775	COG4991	sh3 domain protein
LSP_RS10775	COG0860	N-Acetylmuramoyl-L-alanine amidase
LSP_RS10775	COG3103	Sh3 type 3 domain protein
LSP_RS10780	COG1288	antiporter activity
LSP_RS10800	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LSP_RS10810	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LSP_RS10810	COG1522	sequence-specific DNA binding
LSP_RS10815	COG2271	Major facilitator Superfamily
LSP_RS10830	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
LSP_RS10830	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
LSP_RS10840	COG0159	tryptophan synthase activity
LSP_RS10845	COG0133	tryptophan synthase activity
LSP_RS10850	COG0135	phosphoribosylanthranilate isomerase activity
LSP_RS10855	COG0134	indole-3-glycerol-phosphate synthase activity
LSP_RS10860	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
LSP_RS10865	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
LSP_RS10870	COG0840	transmembrane signaling receptor activity
LSP_RS10875	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LSP_RS10875	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LSP_RS10890	COG2323	membrane
LSP_RS10895	COG1649	PFAM Uncharacterised BCR, COG1649
LSP_RS10895	COG0726	polysaccharide deacetylase
LSP_RS10900	COG1862	Preprotein translocase
LSP_RS10935	COG1827	regulation of RNA biosynthetic process
LSP_RS10940	COG3011	Protein conserved in bacteria
LSP_RS10945	COG0077	Prephenate dehydratase
LSP_RS10965	COG0211	Belongs to the bacterial ribosomal protein bL27 family
LSP_RS10980	COG1994	Peptidase M50
LSP_RS10990	COG2894	cell division
LSP_RS11005	COG1792	Involved in formation and maintenance of cell shape
LSP_RS11010	COG1077	Cell shape determining protein MreB Mrl
LSP_RS11015	COG2003	Belongs to the UPF0758 family
LSP_RS11020	COG0424	maF-like protein
LSP_RS11030	COG0285	dihydrofolate synthase activity
LSP_RS11035	COG0285	dihydrofolate synthase activity
LSP_RS11045	COG0525	valine-tRNA ligase activity
LSP_RS11070	COG0113	porphobilinogen synthase activity
LSP_RS11075	COG1587	Uroporphyrinogen-III synthase
LSP_RS11085	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LSP_RS11115	COG0218	Necessary for normal cell division and for the maintenance of normal septation
LSP_RS11135	COG1477	protein flavinylation
LSP_RS11135	COG0457	Tetratricopeptide repeat
LSP_RS11150	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
LSP_RS11155	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LSP_RS11175	COG0589	response to stress
LSP_RS11190	COG0657	acetylesterase activity
LSP_RS11200	COG2072	flavoprotein involved in K transport
LSP_RS11205	COG2197	response regulator
LSP_RS11220	COG0531	amino acid
LSP_RS11225	COG0697	spore germination
LSP_RS11270	COG2318	DinB family
LSP_RS11275	COG1368	sulfuric ester hydrolase activity
LSP_RS11280	COG3279	Response regulator of the LytR AlgR family
LSP_RS11285	COG3290	protein histidine kinase activity
LSP_RS11295	COG4512	PFAM Accessory gene regulator B
LSP_RS11335	COG1131	(ABC) transporter
LSP_RS11390	COG1028	Short-chain dehydrogenase reductase Sdr
LSP_RS11400	COG3361	conserved protein (COG2071)
LSP_RS11410	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
LSP_RS11415	COG0622	Phosphoesterase
LSP_RS11425	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
LSP_RS11435	COG1846	Transcriptional regulator
LSP_RS11440	COG2197	response regulator
LSP_RS11445	COG0824	Thioesterase
LSP_RS11450	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
LSP_RS11455	COG1053	succinate dehydrogenase
LSP_RS11460	COG2009	succinate dehydrogenase
LSP_RS11465	COG1719	4-vinyl reductase, 4VR
LSP_RS11470	COG0527	aspartate kinase activity
LSP_RS11485	COG3118	belongs to the thioredoxin family
LSP_RS11490	COG1113	amino acid transport
LSP_RS11495	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
LSP_RS11500	COG2086	electron transfer activity
LSP_RS11505	COG1024	Enoyl-CoA hydratase
LSP_RS11510	COG1309	transcriptional regulator
LSP_RS11515	COG0318	PFAM AMP-dependent synthetase and ligase
LSP_RS11520	COG3766	membrane
LSP_RS11525	COG1193	negative regulation of DNA recombination
LSP_RS11530	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
LSP_RS11530	COG1796	DNA polymerase
LSP_RS11550	COG0072	phenylalanine-tRNA ligase activity
LSP_RS11550	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LSP_RS11560	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LSP_RS11565	COG0494	nUDIX hydrolase
LSP_RS11575	COG0596	Alpha beta hydrolase
LSP_RS11580	COG0277	FAD linked oxidase domain protein
LSP_RS11585	COG3858	chitin binding
LSP_RS11585	COG1388	LysM domain
LSP_RS11600	COG5001	Diguanylate cyclase
LSP_RS11600	COG3300	MHYT domain
LSP_RS11615	COG0277	FAD linked oxidase domain protein
LSP_RS11625	COG0765	amino acid transport
LSP_RS11630	COG0765	amino acid transport
LSP_RS11635	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LSP_RS11640	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
LSP_RS11645	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LSP_RS11650	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LSP_RS11655	COG0583	DNA-binding transcription factor activity
LSP_RS11660	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
LSP_RS11670	COG1363	Peptidase, m42
LSP_RS11705	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
LSP_RS11710	COG1484	DNA-dependent DNA replication
LSP_RS11715	COG3611	Membrane attachment protein
LSP_RS11725	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
LSP_RS11730	COG0237	dephospho-CoA kinase activity
LSP_RS11740	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LSP_RS11740	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LSP_RS11755	COG0330	HflC and HflK could
LSP_RS11760	COG1346	cytolysis
LSP_RS11765	COG1380	Effector of murein hydrolase LrgA
LSP_RS11770	COG5002	protein histidine kinase activity
LSP_RS11775	COG0745	RESPONSE REGULATOR receiver
LSP_RS11790	COG0538	isocitrate dehydrogenase activity
LSP_RS11795	COG0372	Belongs to the citrate synthase family
LSP_RS11805	COG3030	protein affecting phage T7 exclusion by the F plasmid
LSP_RS11820	COG0825	malonyl-CoA metabolic process
LSP_RS11830	COG2186	Transcriptional regulator
LSP_RS11835	COG0587	DNA-directed DNA polymerase activity
LSP_RS11840	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
LSP_RS11850	COG4109	DRTGG domain
LSP_RS11860	COG0006	proline dipeptidase activity
LSP_RS11870	COG0589	response to stress
LSP_RS11875	COG0827	DNA restriction-modification system
LSP_RS11880	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
LSP_RS11885	COG1714	RDD family
LSP_RS11890	COG0616	signal peptide processing
LSP_RS11895	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LSP_RS11905	COG0351	phosphomethylpyrimidine kinase
LSP_RS11925	COG1104	cysteine desulfurase activity
LSP_RS11935	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
LSP_RS11940	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
LSP_RS11945	COG1956	GAF domain-containing protein
LSP_RS11950	COG2203	Gaf domain
LSP_RS11950	COG2199	diguanylate cyclase activity
LSP_RS11995	COG2814	Major facilitator Superfamily
LSP_RS12000	COG1846	Transcriptional regulator
LSP_RS12015	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
LSP_RS12035	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
LSP_RS12040	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
LSP_RS12045	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
LSP_RS12050	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LSP_RS12055	COG0454	-acetyltransferase
LSP_RS12060	COG0517	IMP dehydrogenase activity
LSP_RS12065	COG0123	including yeast histone deacetylase and acetoin utilization protein
LSP_RS12075	COG1605	Chorismate mutase
LSP_RS12075	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
LSP_RS12080	COG0849	cell division
LSP_RS12085	COG4980	gas vesicle protein
LSP_RS12090	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
LSP_RS12100	COG1674	ftsk spoiiie
LSP_RS12105	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LSP_RS12110	COG4848	Belongs to the UPF0354 family
LSP_RS12120	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
LSP_RS12125	COG1363	Peptidase, m42
LSP_RS12140	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LSP_RS12150	COG1597	lipid kinase activity
LSP_RS12165	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LSP_RS12170	COG1349	DNA-binding transcription factor activity
LSP_RS12175	COG2211	Major facilitator Superfamily
LSP_RS12180	COG2199	diguanylate cyclase activity
LSP_RS12185	COG1187	pseudouridine synthase activity
LSP_RS12190	COG2244	polysaccharide biosynthetic process
LSP_RS12195	COG0367	asparagine synthase
LSP_RS12200	COG2081	HI0933 family
LSP_RS12210	COG2223	nitrite transmembrane transporter activity
LSP_RS12215	COG0697	spore germination
LSP_RS12220	COG0402	S-adenosylhomocysteine deaminase activity
LSP_RS12225	COG0402	S-adenosylhomocysteine deaminase activity
LSP_RS12235	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LSP_RS12245	COG0444	Belongs to the ABC transporter superfamily
LSP_RS12250	COG4608	Belongs to the ABC transporter superfamily
LSP_RS12260	COG3279	Response regulator of the LytR AlgR family
LSP_RS12275	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LSP_RS12285	COG0659	secondary active sulfate transmembrane transporter activity
LSP_RS12295	COG2814	Major facilitator Superfamily
LSP_RS12300	COG1242	4 iron, 4 sulfur cluster binding
LSP_RS12305	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
LSP_RS12310	COG1115	amino acid carrier protein
LSP_RS12320	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
LSP_RS12325	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
LSP_RS12340	COG1506	peptidase
LSP_RS12345	COG0494	nUDIX hydrolase
LSP_RS12355	COG1414	Transcriptional regulator
LSP_RS12370	COG4608	Belongs to the ABC transporter superfamily
LSP_RS12375	COG0444	Belongs to the ABC transporter superfamily
LSP_RS12380	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LSP_RS12385	COG0601	transmembrane transport
LSP_RS12405	COG4126	flavin adenine dinucleotide binding
LSP_RS12435	COG0318	PFAM AMP-dependent synthetase and ligase
LSP_RS12440	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
LSP_RS12445	COG0596	Alpha beta hydrolase
LSP_RS12455	COG1169	isochorismate synthase
LSP_RS12460	COG1575	Belongs to the MenA family. Type 1 subfamily
LSP_RS12470	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
LSP_RS12475	COG0789	Transcriptional regulator
LSP_RS12480	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LSP_RS12485	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
LSP_RS12490	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LSP_RS12495	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LSP_RS12615	COG1104	cysteine desulfurase activity
LSP_RS12620	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
LSP_RS12625	COG0157	Belongs to the NadC ModD family
LSP_RS12755	COG1285	pathogenesis
LSP_RS12770	COG1979	alcohol dehydrogenase
LSP_RS12780	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LSP_RS12785	COG1012	belongs to the aldehyde dehydrogenase family
LSP_RS12790	COG3829	transcription factor binding
LSP_RS12795	COG1098	S1 RNA binding domain
LSP_RS12805	COG1595	DNA-templated transcription, initiation
LSP_RS12810	COG0733	neurotransmitter:sodium symporter activity
LSP_RS12820	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
LSP_RS12840	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LSP_RS12850	COG2111	Na H antiporter
LSP_RS12850	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
LSP_RS12855	COG2111	Na H antiporter
LSP_RS12860	COG1006	Multisubunit Na H antiporter MnhC subunit
LSP_RS12865	COG0651	ATP synthesis coupled electron transport
LSP_RS12870	COG1863	multisubunit Na H antiporter MnhE subunit
LSP_RS12875	COG2212	antiporter activity
LSP_RS12880	COG1320	monovalent cation:proton antiporter activity
LSP_RS12885	COG0529	Catalyzes the synthesis of activated sulfate
LSP_RS12895	COG0306	phosphate transporter
LSP_RS12905	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
LSP_RS12915	COG4208	sulfate ABC transporter
LSP_RS12930	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
LSP_RS12955	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
LSP_RS12960	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
LSP_RS12970	COG1966	Carbon starvation protein
LSP_RS12995	COG0456	acetyltransferase
LSP_RS13000	COG0316	Belongs to the HesB IscA family
LSP_RS13010	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
LSP_RS13015	COG4837	Protein of unknown function (DUF1462)
LSP_RS13020	COG1252	NADH dehydrogenase
LSP_RS13030	COG0647	UMP catabolic process
LSP_RS13035	COG2445	Protein of unknown function DUF86
LSP_RS13055	COG4470	Protein conserved in bacteria
LSP_RS13060	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
LSP_RS13075	COG0737	Belongs to the 5'-nucleotidase family
LSP_RS13080	COG0730	response to heat
LSP_RS13085	COG1801	Protein of unknown function DUF72
LSP_RS13090	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LSP_RS13095	COG0719	Fe-S assembly protein
LSP_RS13100	COG0822	iron-sulfur transferase activity
LSP_RS13105	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
LSP_RS13110	COG0719	Fe-S assembly protein
LSP_RS13115	COG0396	ATPase activity
LSP_RS13120	COG0583	DNA-binding transcription factor activity
LSP_RS13150	COG1464	Belongs to the NlpA lipoprotein family
LSP_RS13155	COG2011	ABC-type metal ion transport system permease component
LSP_RS13160	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
LSP_RS13165	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LSP_RS13180	COG1393	Belongs to the ArsC family
LSP_RS13185	COG1960	acyl-CoA dehydrogenase activity
LSP_RS13190	COG0183	Belongs to the thiolase family
LSP_RS13195	COG1250	3-hydroxyacyl-CoA dehydrogenase
LSP_RS13195	COG1024	Enoyl-CoA hydratase
LSP_RS13200	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LSP_RS13210	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LSP_RS13235	COG0438	transferase activity, transferring glycosyl groups
LSP_RS13240	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
LSP_RS13245	COG1764	response to oxidative stress
LSP_RS13260	COG1053	succinate dehydrogenase
LSP_RS13275	COG2132	Multicopper oxidase
LSP_RS13280	COG1250	3-hydroxyacyl-CoA dehydrogenase
LSP_RS13280	COG1024	Enoyl-CoA hydratase
LSP_RS13320	COG3773	Cell wall hydrolase
LSP_RS13325	COG0737	Belongs to the 5'-nucleotidase family
LSP_RS13330	COG2814	Major facilitator Superfamily
LSP_RS13345	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
LSP_RS13355	COG0840	transmembrane signaling receptor activity
LSP_RS13460	COG4106	trans-aconitate 2-methyltransferase activity
LSP_RS13490	COG0732	type I restriction modification DNA specificity domain
LSP_RS13520	COG0557	exoribonuclease II activity
LSP_RS13525	COG1647	Serine aminopeptidase, S33
LSP_RS13530	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
LSP_RS13540	COG1785	Belongs to the alkaline phosphatase family
LSP_RS13550	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LSP_RS13555	COG1696	Membrane protein involved in D-alanine export
LSP_RS13565	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
LSP_RS13570	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LSP_RS13585	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
LSP_RS13625	COG1704	LemA family
LSP_RS13630	COG5577	PFAM Coat F domain
LSP_RS13640	COG0765	amino acid transport
LSP_RS13660	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LSP_RS13670	COG0391	Required for morphogenesis under gluconeogenic growth conditions
LSP_RS13680	COG1051	belongs to the nudix hydrolase family
LSP_RS13685	COG0492	ferredoxin-NADP+ reductase activity
LSP_RS13690	COG0457	Tetratricopeptide repeat
LSP_RS13695	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
LSP_RS13695	COG0140	phosphoribosyl-ATP diphosphatase activity
LSP_RS13705	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
LSP_RS13710	COG0131	Imidazoleglycerol-phosphate dehydratase
LSP_RS13715	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
LSP_RS13735	COG0110	maltose O-acetyltransferase activity
LSP_RS13740	COG0546	phosphoglycolate phosphatase activity
LSP_RS13750	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
LSP_RS13760	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
LSP_RS13765	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
LSP_RS13770	COG0586	Pfam SNARE associated Golgi protein
LSP_RS13775	COG0318	PFAM AMP-dependent synthetase and ligase
LSP_RS13780	COG0577	efflux transmembrane transporter activity
LSP_RS13785	COG1136	(ABC) transporter
LSP_RS13795	COG5002	protein histidine kinase activity
LSP_RS13800	COG0745	RESPONSE REGULATOR receiver
LSP_RS13805	COG0095	Lipoate-protein ligase
LSP_RS13815	COG1511	domain protein
LSP_RS13820	COG1309	transcriptional regulator
LSP_RS13830	COG5002	protein histidine kinase activity
LSP_RS13845	COG0463	Glycosyl transferase, family 2
LSP_RS13845	COG0457	Tetratricopeptide repeat
LSP_RS13855	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
LSP_RS13860	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
LSP_RS13865	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
LSP_RS13870	COG2329	Antibiotic biosynthesis monooxygenase
LSP_RS13875	COG4473	ABC transporter
LSP_RS13880	COG1131	(ABC) transporter
LSP_RS13885	COG0537	adenosine 5'-monophosphoramidase activity
LSP_RS13925	COG0840	transmembrane signaling receptor activity
LSP_RS13930	COG3481	metal-dependent phosphohydrolase, HD sub domain
LSP_RS13940	COG0420	3'-5' exonuclease activity
LSP_RS13950	COG1024	Enoyl-CoA hydratase
LSP_RS13955	COG1054	Belongs to the UPF0176 family
LSP_RS13965	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LSP_RS13970	COG1011	Hydrolase
LSP_RS13985	COG2610	gluconate transmembrane transporter activity
LSP_RS13990	COG1929	Belongs to the glycerate kinase type-1 family
LSP_RS13995	COG3835	regulator
LSP_RS14000	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LSP_RS14015	COG0328	RNA-DNA hybrid ribonuclease activity
LSP_RS14040	COG1253	flavin adenine dinucleotide binding
LSP_RS14045	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
LSP_RS14050	COG3708	Transcriptional regulator
LSP_RS14055	COG2378	regulation of single-species biofilm formation
LSP_RS14060	COG3279	Response regulator of the LytR AlgR family
LSP_RS14065	COG2197	response regulator
LSP_RS14070	COG2203	Gaf domain
LSP_RS14070	COG4585	Histidine kinase
LSP_RS14075	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
LSP_RS14080	COG0564	pseudouridine synthase activity
LSP_RS14085	COG0656	L-ascorbic acid biosynthetic process
LSP_RS14090	COG2514	catechol 2,3-dioxygenase activity
LSP_RS14100	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
LSP_RS14105	COG3382	B3 4 domain protein
LSP_RS14115	COG0753	catalase activity
LSP_RS14125	COG1619	proteins homologs of microcin C7 resistance protein MccF
LSP_RS14150	COG1136	(ABC) transporter
LSP_RS14155	COG0577	efflux transmembrane transporter activity
LSP_RS14160	COG3231	kanamycin kinase activity
LSP_RS14190	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
LSP_RS14280	COG4974	Belongs to the 'phage' integrase family
LSP_RS14390	COG0735	belongs to the Fur family
LSP_RS14395	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LSP_RS14400	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
LSP_RS14410	COG4129	membrane
LSP_RS14415	COG3853	Toxic anion resistance protein (TelA)
LSP_RS14430	COG1358	cellular component organization or biogenesis
LSP_RS14445	COG2310	stress, protein
LSP_RS14450	COG2310	stress, protein
LSP_RS14455	COG2310	stress, protein
LSP_RS14460	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LSP_RS14465	COG0601	transmembrane transport
LSP_RS14470	COG0747	negative chemotaxis
LSP_RS14475	COG4608	Belongs to the ABC transporter superfamily
LSP_RS14480	COG0444	Belongs to the ABC transporter superfamily
LSP_RS14485	COG1132	(ABC) transporter
LSP_RS14490	COG3557	Belongs to the UPF0374 family
LSP_RS14500	COG1194	a g-specific adenine glycosylase
LSP_RS14505	COG1988	membrane-bound metal-dependent
LSP_RS14520	COG2137	regulation of response to DNA damage stimulus
LSP_RS14525	COG1090	epimerase
LSP_RS14535	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LSP_RS14540	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LSP_RS14555	COG0477	Major facilitator Superfamily
LSP_RS14565	COG3878	Protein conserved in bacteria
LSP_RS14575	COG2217	Heavy metal translocating P-type atpase
LSP_RS14580	COG1295	ribonuclease BN
LSP_RS14590	COG4840	Belongs to the UPF0435 family
LSP_RS14595	COG1360	Flagellar Motor Protein
LSP_RS14600	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
LSP_RS14605	COG2309	aminopeptidase activity
LSP_RS14610	COG0288	reversible hydration of carbon dioxide
LSP_RS14615	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LSP_RS14630	COG0024	Methionine aminopeptidase
LSP_RS14635	COG3859	Proton-coupled thiamine transporter YuaJ
LSP_RS14645	COG0419	ATPase involved in DNA repair
LSP_RS14650	COG0420	3'-5' exonuclease activity
LSP_RS14660	COG2309	aminopeptidase activity
LSP_RS14670	COG1794	racemase activity, acting on amino acids and derivatives
LSP_RS14685	COG0318	PFAM AMP-dependent synthetase and ligase
LSP_RS14695	COG0840	transmembrane signaling receptor activity
LSP_RS14725	COG1376	ErfK ybiS ycfS ynhG family protein
LSP_RS14735	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
LSP_RS14760	COG2719	SpoVR family
LSP_RS14765	COG2718	Belongs to the UPF0229 family
LSP_RS14770	COG2766	serine protein kinase
LSP_RS14775	COG0739	heme binding
LSP_RS14780	COG0840	transmembrane signaling receptor activity
LSP_RS14790	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LSP_RS14795	COG1028	Short-chain dehydrogenase reductase Sdr
LSP_RS14810	COG4807	Protein conserved in bacteria
LSP_RS14820	COG2814	Major facilitator Superfamily
LSP_RS14825	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LSP_RS14840	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
LSP_RS14845	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
LSP_RS14850	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
LSP_RS14855	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LSP_RS14860	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LSP_RS14865	COG1294	oxidase, subunit
LSP_RS14870	COG1271	oxidase subunit
LSP_RS14875	COG1597	lipid kinase activity
LSP_RS14900	COG4851	CamS sex pheromone cAM373 precursor
LSP_RS14910	COG0210	DNA helicase
LSP_RS14920	COG4496	protein, YerC YecD
LSP_RS14925	COG1470	cell adhesion involved in biofilm formation
LSP_RS14940	COG0151	Belongs to the GarS family
LSP_RS14950	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
LSP_RS14960	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
LSP_RS14975	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LSP_RS14985	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
LSP_RS14990	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
LSP_RS14995	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
LSP_RS15025	COG2252	PERMEase
LSP_RS15030	COG2258	MOSC domain
LSP_RS15040	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LSP_RS15040	COG0519	Catalyzes the synthesis of GMP from XMP
LSP_RS15045	COG1305	Transglutaminase-like
LSP_RS15050	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
LSP_RS15055	COG0714	Associated with various cellular activities
LSP_RS15060	COG1131	(ABC) transporter
LSP_RS15095	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
LSP_RS15100	COG0347	Belongs to the P(II) protein family
LSP_RS15105	COG0004	ammonium transporteR
LSP_RS15110	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LSP_RS15115	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
LSP_RS15120	COG0390	transport system, permease component
LSP_RS15125	COG0506	proline dehydrogenase activity
LSP_RS15130	COG2197	response regulator
LSP_RS15135	COG4585	Histidine kinase
LSP_RS15140	COG3239	Fatty acid desaturase
LSP_RS15150	COG0646	methionine synthase
LSP_RS15150	COG1410	methionine synthase
LSP_RS15155	COG0646	methionine synthase
LSP_RS15155	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
LSP_RS15160	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
LSP_RS15165	COG0840	transmembrane signaling receptor activity
LSP_RS15205	COG1361	Conserved repeat domain
LSP_RS15210	COG1379	DNA repair
LSP_RS15220	COG1309	transcriptional regulator
LSP_RS15225	COG2076	Multidrug Resistance protein
LSP_RS15235	COG1120	ATPase activity
LSP_RS15240	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LSP_RS15245	COG1268	BioY protein
LSP_RS15250	COG1388	LysM domain
LSP_RS15255	COG0745	RESPONSE REGULATOR receiver
LSP_RS15260	COG5002	protein histidine kinase activity
LSP_RS15275	COG0778	Nitroreductase
LSP_RS15280	COG0346	lactoylglutathione lyase activity
LSP_RS15285	COG1846	Transcriptional regulator
LSP_RS15290	COG0753	catalase activity
LSP_RS15305	COG3858	chitin binding
LSP_RS15305	COG1388	LysM domain
LSP_RS15355	COG1120	ATPase activity
LSP_RS15360	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LSP_RS15375	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
LSP_RS15380	COG1266	CAAX protease self-immunity
LSP_RS15385	COG0805	protein transport
LSP_RS15390	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LSP_RS15400	COG0488	(ABC) transporter
LSP_RS15405	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
LSP_RS15410	COG0456	acetyltransferase
LSP_RS15415	COG1214	PFAM Peptidase M22, glycoprotease
LSP_RS15420	COG0802	atpase or kinase
LSP_RS15440	COG0601	transmembrane transport
LSP_RS15445	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LSP_RS15450	COG4172	Belongs to the ABC transporter superfamily
LSP_RS15460	COG4166	transmembrane transport
LSP_RS15465	COG0006	proline dipeptidase activity
LSP_RS15470	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
LSP_RS15475	COG1012	belongs to the aldehyde dehydrogenase family
LSP_RS15480	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LSP_RS15485	COG3938	Belongs to the proline racemase family
LSP_RS15490	COG3938	Belongs to the proline racemase family
LSP_RS15495	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LSP_RS15520	COG1115	amino acid carrier protein
LSP_RS15585	COG2183	response to ionizing radiation
LSP_RS15590	COG1191	sigma factor activity
LSP_RS15595	COG2172	sigma factor antagonist activity
LSP_RS15600	COG1366	Belongs to the anti-sigma-factor antagonist family
LSP_RS15605	COG2208	phosphoserine phosphatase activity
LSP_RS15610	COG2172	sigma factor antagonist activity
LSP_RS15615	COG2337	Toxic component of a toxin-antitoxin (TA) module
LSP_RS15630	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
LSP_RS15635	COG0736	holo-[acyl-carrier-protein] synthase activity
LSP_RS15640	COG0705	Rhomboid family
LSP_RS15645	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LSP_RS15650	COG3428	Bacterial PH domain
LSP_RS15655	COG3402	PFAM membrane-flanked domain
LSP_RS15660	COG0513	Belongs to the DEAD box helicase family
LSP_RS15670	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LSP_RS15675	COG1181	Belongs to the D-alanine--D-alanine ligase family
LSP_RS15685	COG0772	Belongs to the SEDS family
LSP_RS15695	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LSP_RS15700	COG1876	peptidase activity
LSP_RS15725	COG0427	acetyl-CoA hydrolase
LSP_RS15750	COG2996	Protein conserved in bacteria
LSP_RS15780	COG0708	Exodeoxyribonuclease III
LSP_RS15785	COG0812	UDP-N-acetylmuramate dehydrogenase activity
LSP_RS15790	COG1733	regulation of RNA biosynthetic process
LSP_RS15805	COG0737	Belongs to the 5'-nucleotidase family
LSP_RS15815	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
LSP_RS15820	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LSP_RS15820	COG0723	plastoquinol--plastocyanin reductase activity
LSP_RS15825	COG1227	inorganic diphosphatase activity
LSP_RS15835	COG1737	Transcriptional regulator
LSP_RS15840	COG0477	Major facilitator Superfamily
LSP_RS15845	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
LSP_RS15875	COG2197	response regulator
LSP_RS15880	COG4585	Histidine kinase
LSP_RS15890	COG0142	geranyltranstransferase activity
LSP_RS15900	COG2329	Antibiotic biosynthesis monooxygenase
LSP_RS15905	COG4607	ABC-type enterochelin transport system periplasmic component
LSP_RS15910	COG4604	ABC transporter, ATP-binding protein
LSP_RS15915	COG4605	iron ion homeostasis
LSP_RS15920	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LSP_RS15925	COG3949	Membrane
LSP_RS15930	COG4948	Mandelate Racemase Muconate Lactonizing
LSP_RS15940	COG1473	amidohydrolase
LSP_RS15945	COG3104	oligopeptide transport
LSP_RS15950	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
LSP_RS15955	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LSP_RS15965	COG0577	efflux transmembrane transporter activity
LSP_RS15970	COG1136	(ABC) transporter
LSP_RS15975	COG1392	Phosphate transport regulator
LSP_RS15980	COG0306	phosphate transporter
LSP_RS15985	COG2409	Drug exporters of the RND superfamily
LSP_RS15990	COG0400	carboxylic ester hydrolase activity
LSP_RS16005	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
LSP_RS16010	COG0628	permease
LSP_RS16020	COG1434	Gram-negative-bacterium-type cell wall biogenesis
LSP_RS16025	COG0840	transmembrane signaling receptor activity
LSP_RS16035	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
LSP_RS16040	COG0217	transcriptional regulatory protein
LSP_RS16045	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LSP_RS16050	COG0204	Acyl-transferase
LSP_RS16055	COG0500	methyltransferase
LSP_RS16060	COG0534	Mate efflux family protein
LSP_RS16070	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LSP_RS16080	COG0386	Belongs to the glutathione peroxidase family
LSP_RS16090	COG0628	permease
LSP_RS16095	COG3103	Sh3 type 3 domain protein
LSP_RS16095	COG1388	LysM domain
LSP_RS16095	COG0791	NLP P60 protein
LSP_RS16100	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
LSP_RS16105	COG0446	pyridine nucleotide-disulphide oxidoreductase
LSP_RS16110	COG3258	Cytochrome c
LSP_RS16120	COG0730	response to heat
LSP_RS16125	COG0425	Belongs to the sulfur carrier protein TusA family
LSP_RS16130	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LSP_RS16130	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LSP_RS16140	COG0425	Belongs to the sulfur carrier protein TusA family
LSP_RS16140	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LSP_RS16145	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LSP_RS16145	COG0425	Belongs to the sulfur carrier protein TusA family
LSP_RS16155	COG1937	Protein conserved in bacteria
LSP_RS16160	COG1017	nitric oxide dioxygenase activity
LSP_RS16160	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LSP_RS16165	COG1959	2 iron, 2 sulfur cluster binding
LSP_RS16170	COG0456	acetyltransferase
LSP_RS16200	COG0840	transmembrane signaling receptor activity
LSP_RS16215	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LSP_RS16235	COG3424	synthase
LSP_RS16240	COG1755	Isoprenylcysteine carboxyl methyltransferase
LSP_RS16245	COG0523	cobalamin synthesis protein
LSP_RS16285	COG2318	DinB family
LSP_RS16305	COG2819	hydrolase of the alpha beta superfamily
LSP_RS16310	COG1120	ATPase activity
LSP_RS16315	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LSP_RS16320	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LSP_RS16325	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LSP_RS16360	COG0488	(ABC) transporter
LSP_RS16375	COG5504	Zn-dependent protease
LSP_RS16390	COG3377	Domain of unknown function (DUF1805)
LSP_RS16405	COG0697	spore germination
LSP_RS16410	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LSP_RS16445	COG0642	Histidine kinase
LSP_RS16450	COG0745	RESPONSE REGULATOR receiver
LSP_RS16460	COG2814	Major facilitator Superfamily
LSP_RS16465	COG0583	DNA-binding transcription factor activity
LSP_RS16475	COG0656	L-ascorbic acid biosynthetic process
LSP_RS16480	COG1733	regulation of RNA biosynthetic process
LSP_RS16485	COG2814	Major facilitator Superfamily
LSP_RS16490	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
LSP_RS16495	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LSP_RS16510	COG0586	Pfam SNARE associated Golgi protein
LSP_RS16515	COG0561	phosphatase activity
LSP_RS16530	COG2312	Erythromycin esterase
LSP_RS16555	COG4978	Transcriptional regulator
LSP_RS16555	COG0789	Transcriptional regulator
LSP_RS16560	COG0456	acetyltransferase
LSP_RS16565	COG0534	Mate efflux family protein
LSP_RS16575	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LSP_RS16580	COG0628	permease
LSP_RS16590	COG1309	transcriptional regulator
LSP_RS16595	COG2814	Major facilitator Superfamily
LSP_RS16605	COG0657	acetylesterase activity
LSP_RS16610	COG0346	lactoylglutathione lyase activity
LSP_RS16615	COG0431	NADPH-dependent FMN reductase
LSP_RS16630	COG1522	sequence-specific DNA binding
LSP_RS16645	COG0662	Cupin 2, conserved barrel domain protein
LSP_RS16675	COG0745	RESPONSE REGULATOR receiver
LSP_RS16690	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
LSP_RS16700	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LSP_RS16720	COG1131	(ABC) transporter
LSP_RS16740	COG1725	Transcriptional regulator
LSP_RS16745	COG0124	histidyl-tRNA synthetase
LSP_RS16765	COG1595	DNA-templated transcription, initiation
LSP_RS16780	COG1028	Short-chain dehydrogenase reductase Sdr
LSP_RS16785	COG1733	regulation of RNA biosynthetic process
LSP_RS16790	COG1309	transcriptional regulator
LSP_RS16810	COG2274	protein secretion by the type I secretion system
LSP_RS16820	COG2197	response regulator
LSP_RS16825	COG4585	Histidine kinase
LSP_RS16825	COG2203	Gaf domain
LSP_RS16835	COG0142	geranyltranstransferase activity
LSP_RS16860	COG5002	protein histidine kinase activity
LSP_RS16860	COG3850	Histidine kinase
LSP_RS16890	COG1028	Short-chain dehydrogenase reductase Sdr
LSP_RS16895	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LSP_RS16905	COG0693	protein deglycase activity
LSP_RS16915	COG4856	YbbR-like protein
LSP_RS16920	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
LSP_RS16925	COG5662	AntiSigma factor
LSP_RS16930	COG1595	DNA-templated transcription, initiation
LSP_RS16970	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LSP_RS16995	COG2194	sulfuric ester hydrolase activity
LSP_RS17005	COG0489	protein tyrosine kinase activity
LSP_RS17010	COG0860	N-Acetylmuramoyl-L-alanine amidase
LSP_RS17020	COG0666	response to abiotic stimulus
LSP_RS17035	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
LSP_RS17045	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
LSP_RS17050	COG1122	ATPase activity
LSP_RS17055	COG1122	ATPase activity
LSP_RS17065	COG0202	RNA polymerase activity
LSP_RS17080	COG0257	Belongs to the bacterial ribosomal protein bL36 family
LSP_RS17085	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
LSP_RS17100	COG0201	protein transport
LSP_RS17135	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
LSP_RS17155	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
LSP_RS17185	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
LSP_RS17210	COG2056	Na+-H+ antiporter family
LSP_RS17215	COG0577	efflux transmembrane transporter activity
LSP_RS17220	COG1136	(ABC) transporter
LSP_RS17225	COG0642	Histidine kinase
LSP_RS17230	COG0745	RESPONSE REGULATOR receiver
LSP_RS17245	COG0049	tRNA binding
LSP_RS17255	COG1358	cellular component organization or biogenesis
LSP_RS17270	COG2813	Specifically methylates the guanine in position
LSP_RS17295	COG0250	Participates in transcription elongation, termination and antitermination
LSP_RS17300	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
LSP_RS17305	COG0267	Belongs to the bacterial ribosomal protein bL33 family
LSP_RS17315	COG3688	RNA-binding protein containing a PIN domain
LSP_RS17320	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LSP_RS17335	COG1045	serine acetyltransferase
LSP_RS17355	COG4956	integral membrane protein (PIN domain superfamily)
LSP_RS17360	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
LSP_RS17365	COG0542	response to heat
LSP_RS17370	COG3869	Catalyzes the specific phosphorylation of arginine residues in
LSP_RS17375	COG0556	nucleotide-excision repair
LSP_RS17390	COG2226	methyltransferase
LSP_RS17395	COG0598	Magnesium transport protein CorA
LSP_RS17420	COG1607	acyl-coa hydrolase
LSP_RS17425	COG1012	belongs to the aldehyde dehydrogenase family
LSP_RS17440	COG1012	belongs to the aldehyde dehydrogenase family
LSP_RS17505	COG5002	protein histidine kinase activity
LSP_RS17510	COG0745	RESPONSE REGULATOR receiver
LSP_RS17515	COG2329	Antibiotic biosynthesis monooxygenase
LSP_RS17525	COG0583	DNA-binding transcription factor activity
LSP_RS17530	COG0583	DNA-binding transcription factor activity
LSP_RS17555	COG1288	antiporter activity
LSP_RS17560	COG3973	AAA domain
LSP_RS17565	COG1126	abc transporter atp-binding protein
LSP_RS17570	COG0765	amino acid transport
LSP_RS17580	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LSP_RS17585	COG1960	acyl-CoA dehydrogenase activity
LSP_RS17595	COG0346	lactoylglutathione lyase activity
LSP_RS17600	COG0840	transmembrane signaling receptor activity
LSP_RS17605	COG0840	transmembrane signaling receptor activity
LSP_RS17620	COG0840	transmembrane signaling receptor activity
LSP_RS17630	COG3223	Belongs to the PsiE family
LSP_RS17645	COG2208	phosphoserine phosphatase activity
LSP_RS17650	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
LSP_RS17655	COG0784	Response regulator, receiver
LSP_RS17655	COG2205	protein histidine kinase activity
LSP_RS17680	COG0596	Alpha beta hydrolase
LSP_RS17735	COG1802	Transcriptional regulator
LSP_RS17750	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
LSP_RS17755	COG3706	GGDEF domain
LSP_RS17765	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LSP_RS17775	COG0028	Belongs to the TPP enzyme family
LSP_RS17790	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LSP_RS17800	COG2814	Major facilitator Superfamily
LSP_RS17805	COG1404	Belongs to the peptidase S8 family
LSP_RS17815	COG1388	LysM domain
LSP_RS17815	COG3584	3D domain protein
LSP_RS17835	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LSP_RS17840	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
LSP_RS17845	COG4853	Protein conserved in bacteria
LSP_RS17850	COG4863	YycH protein
LSP_RS17855	COG5002	protein histidine kinase activity
LSP_RS17860	COG0745	RESPONSE REGULATOR receiver
LSP_RS17865	COG0739	heme binding
LSP_RS17865	COG1196	nuclear chromosome segregation
LSP_RS17865	COG0741	lytic transglycosylase activity
LSP_RS17870	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
LSP_RS17880	COG0305	Participates in initiation and elongation during chromosome replication
LSP_RS17890	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
LSP_RS17895	COG4241	membrane
LSP_RS17900	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
LSP_RS17910	COG0360	Binds together with S18 to 16S ribosomal RNA
LSP_RS17925	COG0012	GTP binding
LSP_RS17930	COG4481	Protein conserved in bacteria
LSP_RS17935	COG0668	transmembrane transport
LSP_RS17945	COG1811	Na channel or pump
LSP_RS17950	COG1475	DNA binding
LSP_RS17955	COG1192	Involved in chromosome partitioning
LSP_RS17980	COG1847	R3H domain protein
LSP_RS17985	COG0706	membrane insertase activity
LSP_RS17990	COG0594	ribonuclease P activity
LSP_RS18000	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
LSP_RS18005	COG0592	DNA-directed DNA polymerase activity
LSP_RS18010	COG2501	S4 domain
LSP_RS18020	COG0187	DNA topoisomerase II activity
LSP_RS18025	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
LSP_RS18030	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
LSP_RS18060	COG0516	GMP reductase activity
LSP_RS18060	COG0517	IMP dehydrogenase activity
LSP_RS18070	COG0367	asparagine synthase
LSP_RS18075	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LSP_RS18085	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
LSP_RS18100	COG2314	TM2 domain
LSP_RS18110	COG0590	tRNA wobble adenosine to inosine editing
LSP_RS18115	COG0640	Transcriptional regulator
LSP_RS18125	COG1937	Protein conserved in bacteria
LSP_RS18130	COG2608	mercury ion transmembrane transporter activity
LSP_RS18135	COG2217	Heavy metal translocating P-type atpase
LSP_RS18140	COG1428	Deoxynucleoside kinase
LSP_RS18145	COG1428	Deoxynucleoside kinase
LSP_RS18160	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
LSP_RS18170	COG0784	Response regulator, receiver
LSP_RS18175	COG4191	Histidine kinase
LSP_RS18190	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
LSP_RS18235	COG1982	Orn Lys Arg decarboxylase major
LSP_RS18240	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
LSP_RS18245	COG3870	Protein conserved in bacteria
LSP_RS18250	COG1728	Protein conserved in bacteria
LSP_RS18255	COG0470	DNA polymerase III
LSP_RS18260	COG1774	PSP1 C-terminal conserved region
LSP_RS18265	COG4467	Involved in initiation control of chromosome replication
LSP_RS18270	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
LSP_RS18280	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
LSP_RS18285	COG2002	toxin-antitoxin pair type II binding
LSP_RS18295	COG0084	hydrolase, TatD family'
LSP_RS18300	COG3583	domain protein
LSP_RS18300	COG3584	3D domain protein
LSP_RS18315	COG4466	Protein conserved in bacteria
LSP_RS18325	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
LSP_RS18330	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LSP_RS18335	COG0251	oxidation-reduction process
LSP_RS18340	COG2088	sporulation resulting in formation of a cellular spore
LSP_RS18345	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
LSP_RS18360	COG0193	aminoacyl-tRNA hydrolase activity
LSP_RS18370	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
LSP_RS18375	COG2002	toxin-antitoxin pair type II binding
LSP_RS18380	COG2244	polysaccharide biosynthetic process
LSP_RS18385	COG3956	TIGRFAM MazG family protein
LSP_RS18390	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
LSP_RS18410	COG1098	S1 RNA binding domain
LSP_RS18435	COG2208	phosphoserine phosphatase activity
LSP_RS18440	COG0037	tRNA processing
LSP_RS18445	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
LSP_RS18450	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LSP_RS18455	COG0656	L-ascorbic acid biosynthetic process
LSP_RS18465	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
LSP_RS18470	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LSP_RS18475	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
LSP_RS18480	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
LSP_RS18485	COG0512	Glutamine amidotransferase of anthranilate synthase
LSP_RS18490	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LSP_RS18495	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
LSP_RS18500	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
LSP_RS18505	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
LSP_RS18510	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LSP_RS18545	COG2224	Isocitrate lyase
LSP_RS18550	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
LSP_RS18555	COG4122	O-methyltransferase activity
LSP_RS18580	COG5002	protein histidine kinase activity
LSP_RS18580	COG3850	Histidine kinase
LSP_RS18600	COG1937	Protein conserved in bacteria
LSP_RS18620	COG0165	Argininosuccinate lyase
LSP_RS18625	COG4208	sulfate ABC transporter
LSP_RS18630	COG3842	ATPase activity
LSP_RS18635	COG1840	ABC-type Fe3 transport system, periplasmic component
LSP_RS18665	COG1131	(ABC) transporter
LSP_RS18680	COG2323	membrane
LSP_RS18685	COG2223	nitrite transmembrane transporter activity
LSP_RS18695	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
LSP_RS18695	COG2111	Na H antiporter
LSP_RS18700	COG2111	Na H antiporter
LSP_RS18705	COG1006	Multisubunit Na H antiporter MnhC subunit
LSP_RS18710	COG0651	ATP synthesis coupled electron transport
LSP_RS18715	COG1863	multisubunit Na H antiporter MnhE subunit
LSP_RS18720	COG2212	antiporter activity
LSP_RS18725	COG1320	monovalent cation:proton antiporter activity
LSP_RS18730	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LSP_RS18735	COG0765	amino acid transport
LSP_RS18740	COG1126	abc transporter atp-binding protein
LSP_RS18770	COG0456	acetyltransferase
LSP_RS18805	COG3279	Response regulator of the LytR AlgR family
LSP_RS18810	COG2972	Histidine kinase
LSP_RS18810	COG0745	RESPONSE REGULATOR receiver
LSP_RS18815	COG1408	metallophosphoesterase
LSP_RS18820	COG0805	protein transport
LSP_RS18825	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LSP_RS18840	COG0840	transmembrane signaling receptor activity
LSP_RS18870	COG1136	(ABC) transporter
LSP_RS18875	COG0577	efflux transmembrane transporter activity
LSP_RS18885	COG2205	protein histidine kinase activity
LSP_RS18890	COG0745	RESPONSE REGULATOR receiver
LSP_RS18915	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LSP_RS18925	COG1361	Conserved repeat domain
LSP_RS18925	COG2911	Protein conserved in bacteria
LSP_RS18925	COG3266	domain, Protein
LSP_RS18930	COG2819	hydrolase of the alpha beta superfamily
LSP_RS18940	COG2207	Transcriptional regulator
LSP_RS18945	COG2207	Transcriptional regulator
LSP_RS18945	COG0662	Cupin 2, conserved barrel domain protein
LSP_RS18950	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LSP_RS18955	COG0477	Major facilitator Superfamily
LSP_RS18970	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LSP_RS18975	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LSP_RS18980	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LSP_RS18985	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LSP_RS18995	COG3279	Response regulator of the LytR AlgR family
LSP_RS19005	COG0840	transmembrane signaling receptor activity
LSP_RS19020	COG0753	catalase activity
LSP_RS19025	COG2207	Transcriptional regulator
LSP_RS19025	COG0662	Cupin 2, conserved barrel domain protein
LSP_RS19030	COG2986	histidine ammonia-lyase
LSP_RS19040	COG1228	amidohydrolase
LSP_RS19050	COG1335	isochorismatase
LSP_RS19055	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
LSP_RS19065	COG0490	domain, Protein
LSP_RS19065	COG0471	metal ion transport
LSP_RS19170	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
LSP_RS19180	COG2807	transmembrane transport
LSP_RS19185	COG0833	amino acid
LSP_RS19190	COG0745	RESPONSE REGULATOR receiver
LSP_RS19195	COG2205	protein histidine kinase activity
LSP_RS19200	COG1131	(ABC) transporter
LSP_RS19210	COG1914	H( )-stimulated, divalent metal cation uptake system
LSP_RS19215	COG0745	RESPONSE REGULATOR receiver
LSP_RS19220	COG5002	protein histidine kinase activity
LSP_RS19220	COG3850	Histidine kinase
LSP_RS19235	COG0531	amino acid
LSP_RS19245	COG2233	PERMEase
LSP_RS19270	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
LSP_RS19285	COG0154	amidase activity
LSP_RS19295	COG4943	cyclic-guanylate-specific phosphodiesterase activity
LSP_RS19305	COG1823	symporter activity
LSP_RS19320	COG2311	Membrane
LSP_RS19325	COG0745	RESPONSE REGULATOR receiver
LSP_RS19330	COG2205	protein histidine kinase activity
LSP_RS19340	COG2814	Major facilitator Superfamily
LSP_RS19345	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LSP_RS19355	COG1175	transmembrane transport
LSP_RS19360	COG0395	ABC-type sugar transport system, permease component
LSP_RS19365	COG2971	BadF BadG BcrA BcrD
LSP_RS19375	COG1737	Transcriptional regulator
LSP_RS19385	COG1309	transcriptional regulator
LSP_RS19395	COG1252	NADH dehydrogenase
LSP_RS19400	COG0840	transmembrane signaling receptor activity
LSP_RS19405	COG4187	Peptidase family M20/M25/M40
LSP_RS19430	COG2217	Heavy metal translocating P-type atpase
LSP_RS19435	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LSP_RS19460	COG3279	Response regulator of the LytR AlgR family
LSP_RS19465	COG0412	Dienelactone hydrolase
LSP_RS19495	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LSP_RS19495	COG2207	Transcriptional regulator
LSP_RS19500	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
LSP_RS19515	COG3832	glyoxalase III activity
LSP_RS19520	COG1280	lysine exporter protein (LysE YggA)
LSP_RS19525	COG0583	DNA-binding transcription factor activity
LSP_RS19530	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
LSP_RS19535	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
LSP_RS19540	COG0346	lactoylglutathione lyase activity
LSP_RS19560	COG2824	Alkylphosphonate utilization operon protein PhnA
LSP_RS19580	COG0577	efflux transmembrane transporter activity
LSP_RS19585	COG1136	(ABC) transporter
LSP_RS19590	COG2205	protein histidine kinase activity
LSP_RS19595	COG0745	RESPONSE REGULATOR receiver
LSP_RS19610	COG1388	LysM domain
LSP_RS19610	COG3584	3D domain protein
LSP_RS19615	COG2032	superoxide dismutase activity
LSP_RS19620	COG2358	TRAP transporter, solute receptor (TAXI family
LSP_RS19635	COG1473	amidohydrolase
LSP_RS19640	COG1757	Na H antiporter
LSP_RS19670	COG0697	spore germination
LSP_RS19700	COG0427	acetyl-CoA hydrolase
LSP_RS19705	COG0471	metal ion transport
LSP_RS19710	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
LSP_RS19730	COG0166	Belongs to the GPI family
LSP_RS19760	COG1968	undecaprenyl-diphosphatase activity
LSP_RS19765	COG0840	transmembrane signaling receptor activity
LSP_RS19770	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LSP_RS19780	COG1012	belongs to the aldehyde dehydrogenase family
LSP_RS19790	COG1960	acyl-CoA dehydrogenase activity
LSP_RS19800	COG0726	polysaccharide deacetylase
LSP_RS19805	COG2966	Psort location CytoplasmicMembrane, score
LSP_RS19820	COG0697	spore germination
LSP_RS19825	COG1132	(ABC) transporter
LSP_RS19830	COG1132	(ABC) transporter
LSP_RS19835	COG0456	acetyltransferase
LSP_RS19840	COG3973	AAA domain
LSP_RS19845	COG0584	glycerophosphoryl diester phosphodiesterase
LSP_RS19860	COG0778	Nitroreductase
LSP_RS19865	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LSP_RS19870	COG1045	serine acetyltransferase
LSP_RS19885	COG2197	response regulator
LSP_RS19895	COG1846	Transcriptional regulator
LSP_RS19900	COG1393	Belongs to the ArsC family
LSP_RS19905	COG0488	(ABC) transporter
LSP_RS19925	COG0431	NADPH-dependent FMN reductase
LSP_RS19940	COG0463	Glycosyl transferase, family 2
LSP_RS19955	COG1960	acyl-CoA dehydrogenase activity
LSP_RS19960	COG0318	PFAM AMP-dependent synthetase and ligase
LSP_RS19965	COG0439	Biotin carboxylase
LSP_RS19970	COG0511	ligase activity, forming carbon-carbon bonds
LSP_RS19975	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LSP_RS19980	COG1024	Enoyl-CoA hydratase
LSP_RS19985	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LSP_RS20000	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
LSP_RS20005	COG2364	Membrane
LSP_RS20015	COG0156	8-amino-7-oxononanoate synthase activity
LSP_RS20020	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LSP_RS20030	COG1024	Enoyl-CoA hydratase
LSP_RS20035	COG2011	ABC-type metal ion transport system permease component
LSP_RS20045	COG1464	Belongs to the NlpA lipoprotein family
LSP_RS20055	COG0436	Aminotransferase
LSP_RS20065	COG0582	viral genome integration into host DNA
LSP_RS20075	COG1396	sequence-specific DNA binding
LSP_RS20125	COG0305	Participates in initiation and elongation during chromosome replication
LSP_RS20140	COG0629	single-stranded DNA binding
LSP_RS20170	COG0270	DNA (cytosine-5-)-methyltransferase activity
LSP_RS20305	COG4824	toxin secretion phage lysis holin
LSP_RS20350	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LSP_RS20370	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
LSP_RS20380	COG0601	transmembrane transport
LSP_RS20385	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LSP_RS20390	COG0444	Belongs to the ABC transporter superfamily
LSP_RS20395	COG4608	Belongs to the ABC transporter superfamily
LSP_RS20405	COG0673	inositol 2-dehydrogenase activity
LSP_RS20410	COG3623	hexulose-6-phosphate isomerase
LSP_RS20415	COG1940	carbohydrate kinase activity
LSP_RS20425	COG2971	BadF BadG BcrA BcrD
LSP_RS20430	COG0772	Belongs to the SEDS family
LSP_RS20435	COG0840	transmembrane signaling receptor activity
LSP_RS20440	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LSP_RS20445	COG0133	tryptophan synthase activity
LSP_RS20465	COG4120	Belongs to the binding-protein-dependent transport system permease family
LSP_RS20475	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
LSP_RS20480	COG0861	Integral membrane protein TerC family
LSP_RS20485	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
LSP_RS20490	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
LSP_RS20520	COG2363	Small membrane protein
LSP_RS20525	COG1473	amidohydrolase
LSP_RS20535	COG3773	Cell wall hydrolase
LSP_RS20545	COG3253	May function as heme-dependent peroxidase
LSP_RS20565	COG1078	dGTPase activity
LSP_RS20575	COG3764	Sortase (surface protein transpeptidase)
LSP_RS20590	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LSP_RS20595	COG0010	Belongs to the arginase family
LSP_RS20600	COG0582	viral genome integration into host DNA
LSP_RS20625	COG1846	Transcriptional regulator
LSP_RS20710	COG0018	arginyl-trna synthetase
LSP_RS20720	COG0318	PFAM AMP-dependent synthetase and ligase
LSP_RS20725	COG1960	acyl-CoA dehydrogenase activity
LSP_RS20730	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LSP_RS20735	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LSP_RS20740	COG1120	ATPase activity
LSP_RS20745	COG2096	Adenosyltransferase
LSP_RS20750	COG0247	lactate metabolic process
LSP_RS20750	COG2181	nitrate reductase activity
LSP_RS20755	COG0183	Belongs to the thiolase family
LSP_RS20760	COG1250	3-hydroxyacyl-CoA dehydrogenase
LSP_RS20765	COG1960	acyl-CoA dehydrogenase activity
LSP_RS20770	COG1960	acyl-CoA dehydrogenase activity
LSP_RS20775	COG1309	transcriptional regulator
LSP_RS20780	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LSP_RS20780	COG1703	isobutyryl-CoA mutase activity
LSP_RS20780	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LSP_RS20790	COG0504	CTP synthase activity
LSP_RS20795	COG4821	SIS domain
LSP_RS20800	COG2204	response regulator
LSP_RS20815	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LSP_RS20820	COG1494	fructose-1,6-bisphosphatase
LSP_RS20825	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
LSP_RS20830	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LSP_RS20835	COG1132	(ABC) transporter
LSP_RS20840	COG1120	ATPase activity
LSP_RS20845	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LSP_RS20850	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LSP_RS20860	COG0254	rRNA binding
LSP_RS20865	COG1435	thymidine kinase activity
LSP_RS20875	COG2890	protein-(glutamine-N5) methyltransferase activity
LSP_RS20885	COG0009	L-threonylcarbamoyladenylate synthase
LSP_RS20900	COG0840	transmembrane signaling receptor activity
LSP_RS20905	COG0698	ribose 5-phosphate isomerase
LSP_RS20920	COG2203	Gaf domain
LSP_RS20920	COG3706	GGDEF domain
LSP_RS20920	COG4251	negative regulation of phosphorylation
LSP_RS20920	COG5001	Diguanylate cyclase
LSP_RS20930	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
LSP_RS20975	COG0355	proton-transporting ATP synthase activity, rotational mechanism
LSP_RS20980	COG4836	Membrane
LSP_RS20990	COG2385	sporulation resulting in formation of a cellular spore
LSP_RS21000	COG1609	Transcriptional regulator
LSP_RS21005	COG1077	Cell shape determining protein MreB Mrl
LSP_RS21010	COG4786	Flagellar basal body rod
LSP_RS21015	COG4786	Flagellar basal body rod
LSP_RS21025	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LSP_RS21045	COG0629	single-stranded DNA binding
LSP_RS21050	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
LSP_RS21055	COG4715	Zinc finger, swim domain protein
LSP_RS21065	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
LSP_RS21080	COG2244	polysaccharide biosynthetic process
LSP_RS21105	COG0737	Belongs to the 5'-nucleotidase family
LSP_RS21110	COG2356	endonuclease I
LSP_RS21140	COG1361	Conserved repeat domain
LSP_RS21150	COG0860	N-Acetylmuramoyl-L-alanine amidase
LSP_RS21155	COG5263	repeat protein
LSP_RS21155	COG4193	domain, Protein
LSP_RS21160	COG1012	belongs to the aldehyde dehydrogenase family
LSP_RS21165	COG3829	transcription factor binding
LSP_RS21170	COG0506	proline dehydrogenase activity
LSP_RS21175	COG1309	transcriptional regulator
LSP_RS21180	COG0793	Belongs to the peptidase S41A family
LSP_RS21185	COG1114	Component of the transport system for branched-chain amino acids
LSP_RS21190	COG0791	NLP P60 protein
LSP_RS21190	COG1388	LysM domain
LSP_RS21205	COG0653	protein targeting
LSP_RS21210	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LSP_RS21215	COG1316	TRANSCRIPTIONal
LSP_RS21220	COG1739	Uncharacterized protein family UPF0029
LSP_RS21225	COG4585	Histidine kinase
LSP_RS21230	COG2197	response regulator
LSP_RS21240	COG1307	EDD domain protein, DegV family
LSP_RS21270	COG4786	Flagellar basal body rod
LSP_RS21270	COG1256	bacterial-type flagellum assembly
LSP_RS21275	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
LSP_RS21290	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
LSP_RS21295	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
LSP_RS21310	COG1086	Polysaccharide biosynthesis protein
LSP_RS21315	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
LSP_RS21320	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
LSP_RS21335	COG2089	acid synthase
LSP_RS21345	COG1334	flagellar protein FlaG
LSP_RS21350	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
LSP_RS21360	COG1516	flagellar protein fliS
LSP_RS21375	COG0653	protein targeting
LSP_RS21400	COG0556	nucleotide-excision repair
LSP_RS21405	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LSP_RS21415	COG2884	Cell division ATP-binding protein ftsE
LSP_RS21420	COG2177	Part of the ABC transporter FtsEX involved in
LSP_RS21425	COG0739	heme binding
LSP_RS21435	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LSP_RS21440	COG3409	Peptidoglycan-binding domain 1 protein
LSP_RS21440	COG0793	Belongs to the peptidase S41A family
LSP_RS21450	COG4897	Protein conserved in bacteria
LSP_RS21460	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
LSP_RS21465	COG1396	sequence-specific DNA binding
LSP_RS21470	COG0398	Pfam SNARE associated Golgi protein
LSP_RS21485	COG2311	Membrane
LSP_RS21490	COG0179	Fumarylacetoacetate (FAA) hydrolase
LSP_RS21505	COG1307	EDD domain protein, DegV family
LSP_RS21510	COG0561	phosphatase activity
LSP_RS21515	COG1073	alpha beta
LSP_RS21520	COG2151	metal-sulfur cluster biosynthetic enzyme
LSP_RS21525	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LSP_RS21540	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LSP_RS21545	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LSP_RS21560	COG1393	Belongs to the ArsC family
LSP_RS21580	COG1164	Oligoendopeptidase f
LSP_RS21585	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
LSP_RS21590	COG2346	COG2346, Truncated hemoglobins
LSP_RS21595	COG0741	lytic transglycosylase activity
LSP_RS21600	COG4116	CYTH
LSP_RS21610	COG2357	RelA SpoT domain protein
LSP_RS21620	COG0564	pseudouridine synthase activity
LSP_RS21625	COG2239	Acts as a magnesium transporter
LSP_RS21650	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LSP_RS21680	COG2382	esterase
LSP_RS21685	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
LSP_RS21695	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LSP_RS21715	COG1525	nuclease
LSP_RS21725	COG4209	transmembrane transport
LSP_RS21730	COG0395	ABC-type sugar transport system, permease component
LSP_RS21735	COG1653	transport
LSP_RS21740	COG5578	integral membrane protein
LSP_RS21745	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
LSP_RS21750	COG2188	Transcriptional regulator
LSP_RS21760	COG1105	Belongs to the carbohydrate kinase PfkB family
LSP_RS21765	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LSP_RS21775	COG3842	ATPase activity
LSP_RS21780	COG2508	Transcriptional regulator
LSP_RS21795	COG5386	Cell surface protein
LSP_RS21800	COG5386	Cell surface protein
LSP_RS21805	COG5386	Cell surface protein
LSP_RS21820	COG1120	ATPase activity
LSP_RS21825	COG4509	Sortase family
LSP_RS21855	COG0753	catalase activity
LSP_RS21860	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LSP_RS21865	COG0431	NADPH-dependent FMN reductase
LSP_RS21870	COG1012	belongs to the aldehyde dehydrogenase family
LSP_RS21875	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
LSP_RS21880	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
LSP_RS21890	COG3320	Male sterility
LSP_RS21890	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LSP_RS21895	COG0861	Integral membrane protein TerC family
LSP_RS21905	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
LSP_RS21915	COG5002	protein histidine kinase activity
LSP_RS21920	COG1846	Transcriptional regulator
LSP_RS21935	COG4873	Protein conserved in bacteria
LSP_RS21950	COG2084	Dehydrogenase
LSP_RS21955	COG2259	Doxx family
LSP_RS21960	COG1733	regulation of RNA biosynthetic process
LSP_RS21965	COG2270	Major facilitator Superfamily
LSP_RS21970	COG0835	chemotaxis
LSP_RS21970	COG0784	Response regulator, receiver
LSP_RS21975	COG0248	Ppx GppA phosphatase
LSP_RS21980	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
LSP_RS21985	COG3300	MHYT domain
LSP_RS21985	COG5001	Diguanylate cyclase
LSP_RS21990	COG1309	transcriptional regulator
LSP_RS22005	COG2610	gluconate transmembrane transporter activity
LSP_RS22010	COG1028	Short-chain dehydrogenase reductase Sdr
LSP_RS22020	COG1028	Short-chain dehydrogenase reductase Sdr
LSP_RS22030	COG0517	IMP dehydrogenase activity
LSP_RS22035	COG0583	DNA-binding transcription factor activity
LSP_RS22045	COG1131	(ABC) transporter
LSP_RS22060	COG0714	Associated with various cellular activities
LSP_RS22085	COG2814	Major facilitator Superfamily
LSP_RS22090	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
LSP_RS22095	COG1177	transmembrane transport
LSP_RS22100	COG1176	ABC-type spermidine putrescine transport system, permease component I
LSP_RS22115	COG0450	alkyl hydroperoxide reductase
LSP_RS22120	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LSP_RS22125	COG0569	domain protein
LSP_RS22135	COG3340	Belongs to the peptidase S51 family
LSP_RS22140	COG1247	-acetyltransferase
LSP_RS22145	COG1619	proteins homologs of microcin C7 resistance protein MccF
LSP_RS22150	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LSP_RS22160	COG1301	dicarboxylic acid transport
LSP_RS22165	COG3290	protein histidine kinase activity
LSP_RS22175	COG0392	lysyltransferase activity
LSP_RS22175	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
LSP_RS22185	COG1649	PFAM Uncharacterised BCR, COG1649
LSP_RS22190	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LSP_RS22195	COG1309	transcriptional regulator
LSP_RS22200	COG0515	serine threonine protein kinase
LSP_RS22210	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
LSP_RS22220	COG0561	phosphatase activity
LSP_RS22225	COG1349	DNA-binding transcription factor activity
LSP_RS22270	COG0508	dehydrogenase complex catalyzes the overall conversion of
LSP_RS22280	COG1028	Short-chain dehydrogenase reductase Sdr
LSP_RS22295	COG3181	Tripartite tricarboxylate transporter family receptor
LSP_RS22300	COG4565	transcriptional regulatory protein
LSP_RS22305	COG3290	protein histidine kinase activity
LSP_RS22315	COG1346	cytolysis
LSP_RS22325	COG1982	Orn Lys Arg decarboxylase major
LSP_RS22350	COG0483	inositol monophosphate 1-phosphatase activity
LSP_RS22360	COG1217	gtp-binding protein TYPA
LSP_RS22370	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LSP_RS22375	COG1116	anion transmembrane transporter activity
LSP_RS22380	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LSP_RS22385	COG4896	Protein conserved in bacteria
LSP_RS22390	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
LSP_RS22400	COG0772	Belongs to the SEDS family
LSP_RS22405	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
LSP_RS22445	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
LSP_RS22450	COG3336	cytochrome c oxidase
LSP_RS22460	COG0628	permease
LSP_RS22475	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
LSP_RS22485	COG3679	Belongs to the UPF0342 family
LSP_RS22490	COG0473	3-isopropylmalate dehydrogenase activity
LSP_RS22500	COG0584	glycerophosphoryl diester phosphodiesterase
LSP_RS22505	COG4471	UPF0298 protein
LSP_RS22520	COG0742	ribosomal rna small subunit methyltransferase
LSP_RS22535	COG3480	Lon protease (S16) C-terminal proteolytic domain
LSP_RS22555	COG1024	Enoyl-CoA hydratase
LSP_RS22565	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
LSP_RS22580	COG2001	Belongs to the MraZ family
LSP_RS22595	COG0768	penicillin binding
LSP_RS22600	COG0768	penicillin binding
LSP_RS22605	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LSP_RS22610	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
LSP_RS22615	COG0772	Belongs to the SEDS family
LSP_RS22620	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
LSP_RS22625	COG3879	Bacterial protein of unknown function (DUF881)
LSP_RS22635	COG3856	small basic protein
LSP_RS22640	COG0849	cell division
LSP_RS22645	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
LSP_RS22655	COG1191	sigma factor activity
LSP_RS22660	COG1191	sigma factor activity
LSP_RS22670	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
LSP_RS22675	COG1799	cell septum assembly
LSP_RS22680	COG0762	integral membrane protein
LSP_RS22690	COG3599	regulation of cell shape
LSP_RS22715	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
LSP_RS22720	COG0564	pseudouridine synthase activity
LSP_RS22725	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
LSP_RS22735	COG0540	Belongs to the ATCase OTCase family
LSP_RS22760	COG0167	dihydroorotate dehydrogenase activity
LSP_RS22770	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
LSP_RS22775	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LSP_RS22785	COG4608	Belongs to the ABC transporter superfamily
LSP_RS22790	COG0601	transmembrane transport
LSP_RS22795	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LSP_RS22800	COG0747	negative chemotaxis
LSP_RS22805	COG4608	Belongs to the ABC transporter superfamily
LSP_RS22810	COG0444	Belongs to the ABC transporter superfamily
LSP_RS22815	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LSP_RS22820	COG0601	transmembrane transport
LSP_RS22825	COG4166	transmembrane transport
LSP_RS22840	COG1561	YicC-like family, N-terminal region
LSP_RS22855	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
LSP_RS22860	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
LSP_RS22865	COG0242	peptide deformylase activity
LSP_RS22875	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LSP_RS22875	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LSP_RS22885	COG0631	protein serine/threonine phosphatase activity
LSP_RS22890	COG0515	serine threonine protein kinase
LSP_RS22890	COG2815	serine threonine protein kinase
LSP_RS22895	COG1162	GTPase activity
LSP_RS22900	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
LSP_RS22915	COG0227	Belongs to the bacterial ribosomal protein bL28 family
LSP_RS22935	COG0833	amino acid
LSP_RS22940	COG4187	Peptidase family M20/M25/M40
LSP_RS22945	COG1302	Protein conserved in bacteria
LSP_RS22950	COG1461	Dihydroxyacetone kinase
LSP_RS22955	COG1760	l-serine dehydratase
LSP_RS22960	COG1760	l-serine dehydratase
LSP_RS22965	COG0583	DNA-binding transcription factor activity
LSP_RS22970	COG1288	antiporter activity
LSP_RS22975	COG1473	amidohydrolase
LSP_RS22985	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
LSP_RS22990	COG1349	DNA-binding transcription factor activity
LSP_RS22990	COG2050	protein possibly involved in aromatic compounds catabolism
LSP_RS23000	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
LSP_RS23005	COG1028	Short-chain dehydrogenase reductase Sdr
LSP_RS23010	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LSP_RS23015	COG0571	ribonuclease III activity
LSP_RS23020	COG1196	nuclear chromosome segregation
LSP_RS23025	COG0552	protein localization to endoplasmic reticulum
LSP_RS23035	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
LSP_RS23045	COG1837	Belongs to the UPF0109 family
LSP_RS23075	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
LSP_RS23085	COG2257	FlhB HrpN YscU SpaS Family
LSP_RS23090	COG0045	succinate-CoA ligase (ADP-forming) activity
LSP_RS23095	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
LSP_RS23100	COG0758	DNA mediated transformation
LSP_RS23105	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LSP_RS23115	COG4974	Belongs to the 'phage' integrase family
LSP_RS23125	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
LSP_RS23135	COG1815	bacterial-type flagellum-dependent cell motility
LSP_RS23140	COG1558	bacterial-type flagellum-dependent cell motility
LSP_RS23145	COG1677	Flagellar hook-basal body complex protein FliE
LSP_RS23150	COG1766	The M ring may be actively involved in energy transduction
LSP_RS23155	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
LSP_RS23165	COG1157	protein secretion by the type III secretion system
LSP_RS23170	COG2882	bacterial-type flagellum organization
LSP_RS23185	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
LSP_RS23195	COG4786	Flagellar basal body rod
LSP_RS23200	COG1582	Flagellar protein (FlbD)
LSP_RS23205	COG1580	Controls the rotational direction of flagella during chemotaxis
LSP_RS23210	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
LSP_RS23215	COG1776	CheC inhibitor of MCP methylation
LSP_RS23215	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
LSP_RS23220	COG2201	protein-glutamate methylesterase activity
LSP_RS23225	COG3190	flagellar
LSP_RS23230	COG1338	Plays a role in the flagellum-specific transport system
LSP_RS23235	COG1987	bacterial-type flagellum assembly
LSP_RS23240	COG1684	flagellar biosynthetic protein fliR
LSP_RS23245	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
LSP_RS23250	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
LSP_RS23255	COG1419	protein localization to endoplasmic reticulum
LSP_RS23260	COG0455	bacterial-type flagellum organization
LSP_RS23265	COG2201	protein-glutamate methylesterase activity
LSP_RS23270	COG2198	Histidine kinase
LSP_RS23270	COG0643	Histidine kinase
LSP_RS23275	COG0835	chemotaxis
LSP_RS23280	COG1776	CheC inhibitor of MCP methylation
LSP_RS23285	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
LSP_RS23295	COG0590	tRNA wobble adenosine to inosine editing
LSP_RS23300	COG0402	S-adenosylhomocysteine deaminase activity
LSP_RS23305	COG0402	S-adenosylhomocysteine deaminase activity
LSP_RS23310	COG1191	sigma factor activity
LSP_RS23340	COG0233	cytoplasmic translational termination
LSP_RS23350	COG4589	Belongs to the CDS family
LSP_RS23360	COG0750	zinc metalloprotease
LSP_RS23370	COG2176	DNA-directed DNA polymerase activity
LSP_RS23380	COG0195	Participates in both transcription termination and antitermination
LSP_RS23385	COG2740	Nucleic-acid-binding protein implicated in transcription termination
LSP_RS23390	COG1358	cellular component organization or biogenesis
LSP_RS23400	COG1550	Protein conserved in bacteria
LSP_RS23405	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
LSP_RS23410	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
LSP_RS23415	COG0196	riboflavin kinase activity
LSP_RS23435	COG0612	Peptidase, M16
LSP_RS23445	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LSP_RS23455	COG0748	coenzyme F420 binding
LSP_RS23475	COG1725	Transcriptional regulator
LSP_RS23490	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
LSP_RS23495	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
LSP_RS23505	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
LSP_RS23510	COG1674	ftsk spoiiie
LSP_RS23515	COG2188	Transcriptional regulator
LSP_RS23520	COG1744	ABC transporter substrate-binding protein PnrA-like
LSP_RS23525	COG3845	ABC transporter
LSP_RS23530	COG4603	Belongs to the binding-protein-dependent transport system permease family
LSP_RS23535	COG1079	Belongs to the binding-protein-dependent transport system permease family
LSP_RS23540	COG0612	Peptidase, M16
LSP_RS23545	COG0612	Peptidase, M16
LSP_RS23550	COG0300	oxidoreductase activity
LSP_RS23565	COG1426	Protein conserved in bacteria
LSP_RS23570	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family