locus-tag	class	description
BI350_RS00015	COG1116	anion transmembrane transporter activity
BI350_RS00040	COG2801	Transposase and inactivated derivatives
BI350_RS00050	COG2801	Transposase and inactivated derivatives
BI350_RS00055	COG2205	protein histidine kinase activity
BI350_RS00085	COG0697	spore germination
BI350_RS00100	COG1132	(ABC) transporter
BI350_RS00105	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
BI350_RS00110	COG4988	ABC transporter
BI350_RS00115	COG1294	oxidase, subunit
BI350_RS00120	COG1271	oxidase subunit
BI350_RS00125	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BI350_RS00130	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
BI350_RS00175	COG0196	riboflavin kinase activity
BI350_RS00195	COG0166	Belongs to the GPI family
BI350_RS00200	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BI350_RS00205	COG0460	homoserine dehydrogenase
BI350_RS00210	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BI350_RS00215	COG2873	o-acetylhomoserine
BI350_RS00220	COG0730	response to heat
BI350_RS00225	COG0425	Belongs to the sulfur carrier protein TusA family
BI350_RS00235	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BI350_RS00235	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BI350_RS00240	COG0425	Belongs to the sulfur carrier protein TusA family
BI350_RS00240	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BI350_RS00245	COG2210	Belongs to the sulfur carrier protein TusA family
BI350_RS00250	COG1937	Protein conserved in bacteria
BI350_RS00255	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BI350_RS00260	COG1012	belongs to the aldehyde dehydrogenase family
BI350_RS00275	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BI350_RS00290	COG0697	spore germination
BI350_RS00305	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BI350_RS00310	COG0427	acetyl-CoA hydrolase
BI350_RS00325	COG0628	permease
BI350_RS00330	COG2514	catechol 2,3-dioxygenase activity
BI350_RS00335	COG1733	regulation of RNA biosynthetic process
BI350_RS00340	COG2814	Major facilitator Superfamily
BI350_RS00370	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
BI350_RS00375	COG1131	(ABC) transporter
BI350_RS00380	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BI350_RS00395	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BI350_RS00405	COG0640	Transcriptional regulator
BI350_RS00410	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
BI350_RS00415	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BI350_RS00420	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BI350_RS00430	COG2217	Heavy metal translocating P-type atpase
BI350_RS00435	COG2608	mercury ion transmembrane transporter activity
BI350_RS00440	COG1937	Protein conserved in bacteria
BI350_RS00445	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
BI350_RS00450	COG1191	sigma factor activity
BI350_RS00460	COG0385	Bile acid
BI350_RS00470	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BI350_RS00485	COG1733	regulation of RNA biosynthetic process
BI350_RS00490	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
BI350_RS00495	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BI350_RS00505	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
BI350_RS00510	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BI350_RS00520	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BI350_RS00525	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BI350_RS00540	COG1131	(ABC) transporter
BI350_RS00560	COG4263	nitrous-oxide reductase activity
BI350_RS00570	COG1840	ABC-type Fe3 transport system, periplasmic component
BI350_RS00580	COG3842	ATPase activity
BI350_RS00595	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BI350_RS00600	COG0516	GMP reductase activity
BI350_RS00600	COG0517	IMP dehydrogenase activity
BI350_RS00610	COG2409	Drug exporters of the RND superfamily
BI350_RS00620	COG5002	protein histidine kinase activity
BI350_RS00620	COG3850	Histidine kinase
BI350_RS00630	COG1295	ribonuclease BN
BI350_RS00685	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
BI350_RS00725	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BI350_RS00730	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
BI350_RS00735	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
BI350_RS00740	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BI350_RS00745	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BI350_RS00750	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BI350_RS00755	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BI350_RS00760	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
BI350_RS00765	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
BI350_RS00770	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BI350_RS00775	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
BI350_RS00780	COG0037	tRNA processing
BI350_RS00785	COG2208	phosphoserine phosphatase activity
BI350_RS00800	COG1098	S1 RNA binding domain
BI350_RS00820	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
BI350_RS00825	COG3956	TIGRFAM MazG family protein
BI350_RS00830	COG2244	polysaccharide biosynthetic process
BI350_RS00835	COG2002	toxin-antitoxin pair type II binding
BI350_RS00840	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BI350_RS00865	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BI350_RS00870	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BI350_RS00875	COG2088	sporulation resulting in formation of a cellular spore
BI350_RS00880	COG0251	oxidation-reduction process
BI350_RS00885	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BI350_RS00900	COG4466	Protein conserved in bacteria
BI350_RS00915	COG3584	3D domain protein
BI350_RS00915	COG3583	domain protein
BI350_RS00920	COG0084	hydrolase, TatD family'
BI350_RS00930	COG2002	toxin-antitoxin pair type II binding
BI350_RS00935	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
BI350_RS00945	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
BI350_RS00950	COG4467	Involved in initiation control of chromosome replication
BI350_RS00955	COG1774	PSP1 C-terminal conserved region
BI350_RS00960	COG0470	DNA polymerase III
BI350_RS00965	COG1728	Protein conserved in bacteria
BI350_RS00970	COG3870	Protein conserved in bacteria
BI350_RS00980	COG1982	Orn Lys Arg decarboxylase major
BI350_RS01010	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
BI350_RS01015	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
BI350_RS01020	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
BI350_RS01045	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
BI350_RS01050	COG0460	homoserine dehydrogenase
BI350_RS01055	COG0527	aspartate kinase activity
BI350_RS01065	COG1428	Deoxynucleoside kinase
BI350_RS01070	COG1428	Deoxynucleoside kinase
BI350_RS01075	COG0590	tRNA wobble adenosine to inosine editing
BI350_RS01080	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
BI350_RS01085	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
BI350_RS01095	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BI350_RS01105	COG0516	GMP reductase activity
BI350_RS01105	COG0517	IMP dehydrogenase activity
BI350_RS01125	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
BI350_RS01130	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BI350_RS01135	COG0187	DNA topoisomerase II activity
BI350_RS01145	COG2501	S4 domain
BI350_RS01150	COG0592	DNA-directed DNA polymerase activity
BI350_RS01155	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BI350_RS01160	COG0230	Belongs to the bacterial ribosomal protein bL34 family
BI350_RS01165	COG0594	ribonuclease P activity
BI350_RS01170	COG0706	membrane insertase activity
BI350_RS01175	COG1847	R3H domain protein
BI350_RS01200	COG1192	Involved in chromosome partitioning
BI350_RS01205	COG1475	DNA binding
BI350_RS01220	COG0668	transmembrane transport
BI350_RS01225	COG4481	Protein conserved in bacteria
BI350_RS01230	COG0012	GTP binding
BI350_RS01245	COG0629	single-stranded DNA binding
BI350_RS01250	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
BI350_RS01255	COG4241	membrane
BI350_RS01260	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
BI350_RS01265	COG0359	binds to the 23S rRNA
BI350_RS01270	COG0305	Participates in initiation and elongation during chromosome replication
BI350_RS01275	COG1196	nuclear chromosome segregation
BI350_RS01275	COG0741	lytic transglycosylase activity
BI350_RS01275	COG0739	heme binding
BI350_RS01280	COG0745	RESPONSE REGULATOR receiver
BI350_RS01285	COG5002	protein histidine kinase activity
BI350_RS01295	COG4853	Protein conserved in bacteria
BI350_RS01300	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
BI350_RS01305	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BI350_RS01325	COG3437	response regulator, receiver
BI350_RS01330	COG1533	DNA photolyase activity
BI350_RS01335	COG2155	Conserved Protein
BI350_RS01345	COG2015	COG2015, Alkyl sulfatase and related hydrolases
BI350_RS01355	COG2223	nitrite transmembrane transporter activity
BI350_RS01360	COG0456	acetyltransferase
BI350_RS01370	COG2801	Transposase and inactivated derivatives
BI350_RS01385	COG0494	nUDIX hydrolase
BI350_RS01390	COG0657	acetylesterase activity
BI350_RS01395	COG3541	Predicted nucleotidyltransferase
BI350_RS01400	COG2153	protein acetylation
BI350_RS01405	COG1496	oxidoreductase activity
BI350_RS01415	COG2801	Transposase and inactivated derivatives
BI350_RS01425	COG0583	DNA-binding transcription factor activity
BI350_RS01450	COG2270	Major facilitator Superfamily
BI350_RS01465	COG3279	Response regulator of the LytR AlgR family
BI350_RS01470	COG0427	acetyl-CoA hydrolase
BI350_RS01480	COG2027	D-alanyl-D-alanine carboxypeptidase
BI350_RS01485	COG1187	pseudouridine synthase activity
BI350_RS01495	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BI350_RS01500	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BI350_RS01505	COG0134	indole-3-glycerol-phosphate synthase activity
BI350_RS01510	COG0135	phosphoribosylanthranilate isomerase activity
BI350_RS01515	COG0133	tryptophan synthase activity
BI350_RS01520	COG0159	tryptophan synthase activity
BI350_RS01535	COG4608	Belongs to the ABC transporter superfamily
BI350_RS01540	COG0601	transmembrane transport
BI350_RS01555	COG0601	transmembrane transport
BI350_RS01560	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BI350_RS01565	COG0444	Belongs to the ABC transporter superfamily
BI350_RS01570	COG4166	transmembrane transport
BI350_RS01575	COG1619	proteins homologs of microcin C7 resistance protein MccF
BI350_RS01580	COG4608	Belongs to the ABC transporter superfamily
BI350_RS01585	COG1607	acyl-coa hydrolase
BI350_RS01610	COG1725	Transcriptional regulator
BI350_RS01615	COG1131	(ABC) transporter
BI350_RS01620	COG1131	(ABC) transporter
BI350_RS01625	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
BI350_RS01630	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
BI350_RS01640	COG0312	modulator of DNA gyrase
BI350_RS01645	COG0312	modulator of DNA gyrase
BI350_RS01655	COG3695	enzyme binding
BI350_RS01665	COG0671	phosphoesterase, PA-phosphatase related
BI350_RS01675	COG1228	amidohydrolase
BI350_RS01690	COG3239	Fatty acid desaturase
BI350_RS01695	COG4585	Histidine kinase
BI350_RS01700	COG2197	response regulator
BI350_RS01705	COG3844	kynureninase activity
BI350_RS01715	COG3483	tryptophan 2,3-dioxygenase activity
BI350_RS01725	COG0346	lactoylglutathione lyase activity
BI350_RS01730	COG0542	response to heat
BI350_RS01745	COG0697	spore germination
BI350_RS01760	COG1834	amidinotransferase
BI350_RS01765	COG0252	asparaginase activity
BI350_RS01780	COG0494	nUDIX hydrolase
BI350_RS01785	COG1061	Type III restriction enzyme res subunit
BI350_RS01835	COG1011	Hydrolase
BI350_RS01845	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BI350_RS01855	COG0351	phosphomethylpyrimidine kinase
BI350_RS01870	COG0400	carboxylic ester hydrolase activity
BI350_RS01875	COG0655	NAD(P)H dehydrogenase (quinone) activity
BI350_RS01880	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BI350_RS01895	COG1473	amidohydrolase
BI350_RS01900	COG1012	belongs to the aldehyde dehydrogenase family
BI350_RS01910	COG3011	Protein conserved in bacteria
BI350_RS01935	COG1268	BioY protein
BI350_RS01940	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
BI350_RS01960	COG3869	Catalyzes the specific phosphorylation of arginine residues in
BI350_RS01965	COG0542	response to heat
BI350_RS01970	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
BI350_RS01975	COG4956	integral membrane protein (PIN domain superfamily)
BI350_RS01990	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BI350_RS01995	COG1045	serine acetyltransferase
BI350_RS02010	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BI350_RS02015	COG3688	RNA-binding protein containing a PIN domain
BI350_RS02025	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BI350_RS02030	COG0250	Participates in transcription elongation, termination and antitermination
BI350_RS02050	COG0222	ribosome binding
BI350_RS02055	COG2813	Specifically methylates the guanine in position
BI350_RS02070	COG1358	cellular component organization or biogenesis
BI350_RS02080	COG0049	tRNA binding
BI350_RS02085	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BI350_RS02095	COG2056	Na+-H+ antiporter family
BI350_RS02105	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BI350_RS02120	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
BI350_RS02125	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
BI350_RS02135	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
BI350_RS02140	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BI350_RS02145	COG0255	Belongs to the universal ribosomal protein uL29 family
BI350_RS02150	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BI350_RS02165	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
BI350_RS02180	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
BI350_RS02185	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
BI350_RS02200	COG0200	Binds to the 23S rRNA
BI350_RS02205	COG0201	protein transport
BI350_RS02215	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
BI350_RS02220	COG0257	Belongs to the bacterial ribosomal protein bL36 family
BI350_RS02235	COG0202	RNA polymerase activity
BI350_RS02245	COG1122	ATPase activity
BI350_RS02250	COG1122	ATPase activity
BI350_RS02255	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
BI350_RS02260	COG0101	tRNA pseudouridine synthase activity
BI350_RS02265	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
BI350_RS02295	COG4294	response to UV
BI350_RS02300	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BI350_RS02305	COG0860	N-Acetylmuramoyl-L-alanine amidase
BI350_RS02310	COG0489	protein tyrosine kinase activity
BI350_RS02320	COG2194	sulfuric ester hydrolase activity
BI350_RS02355	COG3300	MHYT domain
BI350_RS02355	COG5001	Diguanylate cyclase
BI350_RS02360	COG0010	Belongs to the arginase family
BI350_RS02365	COG1595	DNA-templated transcription, initiation
BI350_RS02370	COG5662	AntiSigma factor
BI350_RS02375	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
BI350_RS02380	COG4856	YbbR-like protein
BI350_RS02395	COG1574	metal-dependent hydrolase with the TIM-barrel fold
BI350_RS02400	COG4895	conserved protein (DUF2196)
BI350_RS02415	COG0789	Transcriptional regulator
BI350_RS02420	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
BI350_RS02425	COG1279	arginine transmembrane transporter activity
BI350_RS02445	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BI350_RS02455	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BI350_RS02460	COG2022	thiamine diphosphate biosynthetic process
BI350_RS02465	COG2104	thiamine diphosphate biosynthetic process
BI350_RS02470	COG0352	thiamine-phosphate diphosphorylase activity
BI350_RS02475	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BI350_RS02500	COG0655	NAD(P)H dehydrogenase (quinone) activity
BI350_RS02505	COG2032	superoxide dismutase activity
BI350_RS02510	COG2340	Cysteine-rich secretory protein family
BI350_RS02515	COG0500	methyltransferase
BI350_RS02540	COG2409	Drug exporters of the RND superfamily
BI350_RS02545	COG1278	Cold shock
BI350_RS02550	COG0306	phosphate transporter
BI350_RS02555	COG1392	Phosphate transport regulator
BI350_RS02560	COG1585	Membrane protein implicated in regulation of membrane protease activity
BI350_RS02565	COG2268	Band 7 protein
BI350_RS02575	COG1136	(ABC) transporter
BI350_RS02580	COG0577	efflux transmembrane transporter activity
BI350_RS02590	COG2610	gluconate transmembrane transporter activity
BI350_RS02600	COG2084	Dehydrogenase
BI350_RS02605	COG1802	Transcriptional regulator
BI350_RS02630	COG0318	PFAM AMP-dependent synthetase and ligase
BI350_RS02635	COG0590	tRNA wobble adenosine to inosine editing
BI350_RS02640	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BI350_RS02650	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BI350_RS02655	COG1132	(ABC) transporter
BI350_RS02665	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BI350_RS02670	COG4605	iron ion homeostasis
BI350_RS02675	COG4604	ABC transporter, ATP-binding protein
BI350_RS02680	COG4607	ABC-type enterochelin transport system periplasmic component
BI350_RS02685	COG0477	Major facilitator Superfamily
BI350_RS02695	COG1125	glycine betaine transport
BI350_RS02695	COG0517	IMP dehydrogenase activity
BI350_RS02705	COG1732	Glycine betaine
BI350_RS02715	COG2094	Belongs to the DNA glycosylase MPG family
BI350_RS02720	COG0693	protein deglycase activity
BI350_RS02725	COG0596	Alpha beta hydrolase
BI350_RS02735	COG1959	2 iron, 2 sulfur cluster binding
BI350_RS02745	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BI350_RS02745	COG0723	plastoquinol--plastocyanin reductase activity
BI350_RS02750	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
BI350_RS02760	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BI350_RS02770	COG2111	Na H antiporter
BI350_RS02770	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BI350_RS02775	COG2111	Na H antiporter
BI350_RS02780	COG1006	Multisubunit Na H antiporter MnhC subunit
BI350_RS02785	COG0651	ATP synthesis coupled electron transport
BI350_RS02790	COG1863	multisubunit Na H antiporter MnhE subunit
BI350_RS02795	COG2212	antiporter activity
BI350_RS02800	COG1320	monovalent cation:proton antiporter activity
BI350_RS02810	COG1476	TRANSCRIPTIONal
BI350_RS02845	COG2996	Protein conserved in bacteria
BI350_RS02855	COG0346	lactoylglutathione lyase activity
BI350_RS02880	COG4753	response regulator
BI350_RS02880	COG2207	Transcriptional regulator
BI350_RS02895	COG2814	Major facilitator Superfamily
BI350_RS02905	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BI350_RS02910	COG1823	symporter activity
BI350_RS02925	COG2814	Major facilitator Superfamily
BI350_RS02935	COG0772	Belongs to the SEDS family
BI350_RS02940	COG1181	Belongs to the D-alanine--D-alanine ligase family
BI350_RS02945	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BI350_RS02955	COG0513	Belongs to the DEAD box helicase family
BI350_RS02960	COG3402	PFAM membrane-flanked domain
BI350_RS02965	COG3428	Bacterial PH domain
BI350_RS02970	COG0705	Rhomboid family
BI350_RS02980	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
BI350_RS02995	COG2337	Toxic component of a toxin-antitoxin (TA) module
BI350_RS03000	COG1366	Belongs to the anti-sigma-factor antagonist family
BI350_RS03005	COG1366	Belongs to the anti-sigma-factor antagonist family
BI350_RS03010	COG2172	sigma factor antagonist activity
BI350_RS03015	COG2208	phosphoserine phosphatase activity
BI350_RS03020	COG1366	Belongs to the anti-sigma-factor antagonist family
BI350_RS03025	COG2172	sigma factor antagonist activity
BI350_RS03030	COG1191	sigma factor activity
BI350_RS03035	COG2208	phosphoserine phosphatase activity
BI350_RS03040	COG2183	response to ionizing radiation
BI350_RS03045	COG3091	SprT-like family
BI350_RS03100	COG0802	atpase or kinase
BI350_RS03105	COG1214	PFAM Peptidase M22, glycoprotease
BI350_RS03110	COG0456	acetyltransferase
BI350_RS03115	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BI350_RS03120	COG0488	(ABC) transporter
BI350_RS03125	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
BI350_RS03130	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BI350_RS03135	COG0805	protein transport
BI350_RS03140	COG1266	CAAX protease self-immunity
BI350_RS03205	COG0753	catalase activity
BI350_RS03245	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
BI350_RS03250	COG2267	carboxylic ester hydrolase activity
BI350_RS03255	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BI350_RS03260	COG0826	peptidase U32
BI350_RS03270	COG5001	Diguanylate cyclase
BI350_RS03270	COG3300	MHYT domain
BI350_RS03290	COG0471	metal ion transport
BI350_RS03290	COG0490	domain, Protein
BI350_RS03310	COG0596	Alpha beta hydrolase
BI350_RS03340	COG3655	Transcriptional regulator
BI350_RS03345	COG3739	integral membrane protein
BI350_RS03390	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BI350_RS03395	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BI350_RS03400	COG1268	BioY protein
BI350_RS03405	COG0318	PFAM AMP-dependent synthetase and ligase
BI350_RS03410	COG0183	Belongs to the thiolase family
BI350_RS03420	COG2030	dehydratase
BI350_RS03425	COG0733	neurotransmitter:sodium symporter activity
BI350_RS03430	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
BI350_RS03440	COG1136	(ABC) transporter
BI350_RS03445	COG0577	efflux transmembrane transporter activity
BI350_RS03455	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BI350_RS03460	COG0626	cystathionine gamma-synthase activity
BI350_RS03465	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BI350_RS03470	COG0534	Mate efflux family protein
BI350_RS03475	COG2824	Alkylphosphonate utilization operon protein PhnA
BI350_RS03495	COG1454	alcohol dehydrogenase
BI350_RS03495	COG1012	belongs to the aldehyde dehydrogenase family
BI350_RS03500	COG1119	ATPase activity
BI350_RS03505	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
BI350_RS03515	COG0714	Associated with various cellular activities
BI350_RS03520	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
BI350_RS03525	COG1305	Transglutaminase-like
BI350_RS03530	COG0519	Catalyzes the synthesis of GMP from XMP
BI350_RS03530	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BI350_RS03535	COG2252	PERMEase
BI350_RS03555	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
BI350_RS03565	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
BI350_RS03570	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
BI350_RS03575	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BI350_RS03590	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
BI350_RS03600	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
BI350_RS03610	COG0151	Belongs to the GarS family
BI350_RS03615	COG3338	carbonate dehydratase activity
BI350_RS03625	COG1404	Belongs to the peptidase S8 family
BI350_RS03650	COG1470	cell adhesion involved in biofilm formation
BI350_RS03655	COG4496	protein, YerC YecD
BI350_RS03665	COG0210	DNA helicase
BI350_RS03675	COG4851	CamS sex pheromone cAM373 precursor
BI350_RS03690	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BI350_RS03695	COG1597	lipid kinase activity
BI350_RS03700	COG0494	nUDIX hydrolase
BI350_RS03705	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BI350_RS03710	COG5002	protein histidine kinase activity
BI350_RS03710	COG5001	Diguanylate cyclase
BI350_RS03725	COG0662	Cupin 2, conserved barrel domain protein
BI350_RS03740	COG0446	pyridine nucleotide-disulphide oxidoreductase
BI350_RS03745	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BI350_RS03745	COG0425	Belongs to the sulfur carrier protein TusA family
BI350_RS03755	COG2404	hydrolase activity, acting on ester bonds
BI350_RS03765	COG1757	Na H antiporter
BI350_RS03780	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BI350_RS03800	COG1716	ATPase activity
BI350_RS03800	COG5001	Diguanylate cyclase
BI350_RS03810	COG0579	oxidoreductase
BI350_RS03815	COG1966	Carbon starvation protein
BI350_RS03820	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BI350_RS03830	COG2046	Belongs to the sulfate adenylyltransferase family
BI350_RS03835	COG0581	inorganic phosphate transmembrane transporter activity
BI350_RS03840	COG0573	inorganic phosphate transmembrane transporter activity
BI350_RS03850	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BI350_RS03880	COG2766	serine protein kinase
BI350_RS03885	COG2718	Belongs to the UPF0229 family
BI350_RS03890	COG2719	SpoVR family
BI350_RS03895	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BI350_RS03900	COG0564	pseudouridine synthase activity
BI350_RS03910	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BI350_RS03930	COG1794	racemase activity, acting on amino acids and derivatives
BI350_RS03940	COG0024	Methionine aminopeptidase
BI350_RS03950	COG3859	Proton-coupled thiamine transporter YuaJ
BI350_RS03965	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BI350_RS03970	COG0288	reversible hydration of carbon dioxide
BI350_RS03975	COG2309	aminopeptidase activity
BI350_RS03980	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
BI350_RS03985	COG1360	Flagellar Motor Protein
BI350_RS03990	COG4840	Belongs to the UPF0435 family
BI350_RS03995	COG1115	amino acid carrier protein
BI350_RS04005	COG1295	ribonuclease BN
BI350_RS04010	COG0477	Major facilitator Superfamily
BI350_RS04020	COG1090	epimerase
BI350_RS04035	COG1988	membrane-bound metal-dependent
BI350_RS04045	COG1028	Short-chain dehydrogenase reductase Sdr
BI350_RS04055	COG3557	Belongs to the UPF0374 family
BI350_RS04060	COG1132	(ABC) transporter
BI350_RS04065	COG0444	Belongs to the ABC transporter superfamily
BI350_RS04070	COG4608	Belongs to the ABC transporter superfamily
BI350_RS04075	COG0747	negative chemotaxis
BI350_RS04080	COG0601	transmembrane transport
BI350_RS04085	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BI350_RS04090	COG4129	membrane
BI350_RS04100	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BI350_RS04105	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BI350_RS04110	COG0735	belongs to the Fur family
BI350_RS04230	COG3382	B3 4 domain protein
BI350_RS04235	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BI350_RS04240	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
BI350_RS04250	COG2252	PERMEase
BI350_RS04255	COG0564	pseudouridine synthase activity
BI350_RS04260	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BI350_RS04265	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
BI350_RS04275	COG1253	flavin adenine dinucleotide binding
BI350_RS04280	COG1132	(ABC) transporter
BI350_RS04285	COG1132	(ABC) transporter
BI350_RS04290	COG2226	methyltransferase
BI350_RS04300	COG0640	Transcriptional regulator
BI350_RS04315	COG2814	Major facilitator Superfamily
BI350_RS04320	COG2801	Transposase and inactivated derivatives
BI350_RS04355	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BI350_RS04360	COG1024	Enoyl-CoA hydratase
BI350_RS04375	COG4152	abc transporter atp-binding protein
BI350_RS04380	COG1668	transmembrane transport
BI350_RS04385	COG0420	3'-5' exonuclease activity
BI350_RS04390	COG4717	serine-type aminopeptidase activity
BI350_RS04395	COG3481	metal-dependent phosphohydrolase, HD sub domain
BI350_RS04415	COG0537	adenosine 5'-monophosphoramidase activity
BI350_RS04420	COG1131	(ABC) transporter
BI350_RS04425	COG4473	ABC transporter
BI350_RS04435	COG0556	nucleotide-excision repair
BI350_RS04440	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BI350_RS04445	COG3595	metallopeptidase activity
BI350_RS04445	COG3595	metallopeptidase activity
BI350_RS04450	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
BI350_RS04465	COG0110	maltose O-acetyltransferase activity
BI350_RS04470	COG0457	Tetratricopeptide repeat
BI350_RS04475	COG0492	ferredoxin-NADP+ reductase activity
BI350_RS04480	COG1051	belongs to the nudix hydrolase family
BI350_RS04490	COG0391	Required for morphogenesis under gluconeogenic growth conditions
BI350_RS04500	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BI350_RS04510	COG1704	LemA family
BI350_RS04520	COG0740	serine-type endopeptidase activity
BI350_RS04530	COG2390	Transcriptional regulator
BI350_RS04535	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BI350_RS04560	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BI350_RS04570	COG0557	exoribonuclease II activity
BI350_RS04595	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BI350_RS04600	COG1960	acyl-CoA dehydrogenase activity
BI350_RS04615	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
BI350_RS04625	COG0747	negative chemotaxis
BI350_RS04640	COG2217	Heavy metal translocating P-type atpase
BI350_RS04645	COG3381	protein complex oligomerization
BI350_RS04650	COG0243	molybdopterin cofactor binding
BI350_RS04655	COG0437	4 iron, 4 sulfur cluster binding
BI350_RS04675	COG0805	protein transport
BI350_RS04680	COG0783	Belongs to the Dps family
BI350_RS04705	COG0864	Transcriptional regulator
BI350_RS04715	COG0601	transmembrane transport
BI350_RS04720	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BI350_RS04730	COG1124	(ABC) transporter
BI350_RS04735	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BI350_RS04750	COG5386	Cell surface protein
BI350_RS04770	COG1120	ATPase activity
BI350_RS04775	COG4509	Sortase family
BI350_RS04780	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BI350_RS04790	COG1024	Enoyl-CoA hydratase
BI350_RS04790	COG1250	3-hydroxyacyl-CoA dehydrogenase
BI350_RS04795	COG0183	Belongs to the thiolase family
BI350_RS04800	COG1960	acyl-CoA dehydrogenase activity
BI350_RS04805	COG1393	Belongs to the ArsC family
BI350_RS04810	COG0509	glycine decarboxylation via glycine cleavage system
BI350_RS04815	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
BI350_RS04820	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BI350_RS04825	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BI350_RS04830	COG2011	ABC-type metal ion transport system permease component
BI350_RS04835	COG1464	Belongs to the NlpA lipoprotein family
BI350_RS04845	COG0396	ATPase activity
BI350_RS04850	COG0719	Fe-S assembly protein
BI350_RS04855	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BI350_RS04860	COG0822	iron-sulfur transferase activity
BI350_RS04865	COG0719	Fe-S assembly protein
BI350_RS04875	COG0402	S-adenosylhomocysteine deaminase activity
BI350_RS04885	COG3546	catalase activity
BI350_RS04895	COG2112	serine threonine protein kinase
BI350_RS04900	COG1801	Protein of unknown function DUF72
BI350_RS04905	COG0730	response to heat
BI350_RS04910	COG0737	Belongs to the 5'-nucleotidase family
BI350_RS04920	COG1757	Na H antiporter
BI350_RS04925	COG0733	neurotransmitter:sodium symporter activity
BI350_RS04930	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
BI350_RS04935	COG4470	Protein conserved in bacteria
BI350_RS04945	COG2445	Protein of unknown function DUF86
BI350_RS04950	COG0647	UMP catabolic process
BI350_RS04955	COG4844	belongs to the
BI350_RS04960	COG1252	NADH dehydrogenase
BI350_RS04965	COG4837	Protein of unknown function (DUF1462)
BI350_RS04970	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
BI350_RS04975	COG0316	Belongs to the HesB IscA family
BI350_RS04985	COG1252	NADH dehydrogenase
BI350_RS04995	COG2801	Transposase and inactivated derivatives
BI350_RS05005	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
BI350_RS05010	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BI350_RS05020	COG1320	monovalent cation:proton antiporter activity
BI350_RS05025	COG2212	antiporter activity
BI350_RS05030	COG1863	multisubunit Na H antiporter MnhE subunit
BI350_RS05035	COG0651	ATP synthesis coupled electron transport
BI350_RS05040	COG1006	Multisubunit Na H antiporter MnhC subunit
BI350_RS05045	COG2111	Na H antiporter
BI350_RS05050	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BI350_RS05050	COG2111	Na H antiporter
BI350_RS05070	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BI350_RS05075	COG2814	Major facilitator Superfamily
BI350_RS05080	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BI350_RS05090	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
BI350_RS05100	COG3344	reverse transcriptase
BI350_RS05110	COG0840	transmembrane signaling receptor activity
BI350_RS05115	COG0840	transmembrane signaling receptor activity
BI350_RS05120	COG0733	neurotransmitter:sodium symporter activity
BI350_RS05130	COG1098	S1 RNA binding domain
BI350_RS05135	COG3829	transcription factor binding
BI350_RS05140	COG1012	belongs to the aldehyde dehydrogenase family
BI350_RS05145	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BI350_RS05155	COG2155	Conserved Protein
BI350_RS05160	COG1979	alcohol dehydrogenase
BI350_RS05170	COG1285	pathogenesis
BI350_RS05210	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
BI350_RS05305	COG1575	Belongs to the MenA family. Type 1 subfamily
BI350_RS05310	COG1169	isochorismate synthase
BI350_RS05320	COG0596	Alpha beta hydrolase
BI350_RS05325	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
BI350_RS05335	COG4948	Mandelate Racemase Muconate Lactonizing
BI350_RS05345	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
BI350_RS05350	COG0783	Belongs to the Dps family
BI350_RS05365	COG0494	nUDIX hydrolase
BI350_RS05370	COG1506	peptidase
BI350_RS05385	COG0387	Pfam Sodium calcium exchanger
BI350_RS05395	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
BI350_RS05400	COG2267	carboxylic ester hydrolase activity
BI350_RS05425	COG0210	DNA helicase
BI350_RS05430	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BI350_RS05435	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BI350_RS05445	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BI350_RS05450	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BI350_RS05455	COG4260	virion core protein, lumpy skin disease virus
BI350_RS05460	COG1525	nuclease
BI350_RS05465	COG2323	membrane
BI350_RS05470	COG1757	Na H antiporter
BI350_RS05475	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BI350_RS05480	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BI350_RS05485	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BI350_RS05490	COG1116	anion transmembrane transporter activity
BI350_RS05495	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
BI350_RS05500	COG1755	Isoprenylcysteine carboxyl methyltransferase
BI350_RS05505	COG3424	synthase
BI350_RS05510	COG1671	Belongs to the UPF0178 family
BI350_RS05520	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BI350_RS05570	COG1595	DNA-templated transcription, initiation
BI350_RS05605	COG3344	reverse transcriptase
BI350_RS05630	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
BI350_RS05650	COG1950	PFAM Membrane protein of
BI350_RS05675	COG2801	Transposase and inactivated derivatives
BI350_RS05690	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
BI350_RS05695	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BI350_RS05700	COG1388	LysM domain
BI350_RS05700	COG3584	3D domain protein
BI350_RS05720	COG0584	glycerophosphoryl diester phosphodiesterase
BI350_RS05735	COG1309	transcriptional regulator
BI350_RS05740	COG2076	Multidrug Resistance protein
BI350_RS05770	COG5577	PFAM Coat F domain
BI350_RS05775	COG1388	LysM domain
BI350_RS05775	COG3858	chitin binding
BI350_RS05780	COG0129	dihydroxy-acid dehydratase activity
BI350_RS05785	COG0129	dihydroxy-acid dehydratase activity
BI350_RS05790	COG1011	Hydrolase
BI350_RS05800	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BI350_RS05805	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BI350_RS05810	COG0137	argininosuccinate synthase activity
BI350_RS05815	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
BI350_RS05820	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
BI350_RS05825	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
BI350_RS05830	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
BI350_RS05835	COG0131	Imidazoleglycerol-phosphate dehydratase
BI350_RS05840	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
BI350_RS05845	COG0107	imidazoleglycerol-phosphate synthase activity
BI350_RS05850	COG0140	phosphoribosyl-ATP diphosphatase activity
BI350_RS05850	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
BI350_RS05875	COG0820	rRNA (adenine-C2-)-methyltransferase activity
BI350_RS05880	COG0768	penicillin binding
BI350_RS05890	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
BI350_RS05900	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
BI350_RS05905	COG1984	allophanate hydrolase subunit 2
BI350_RS05910	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
BI350_RS05915	COG1999	signal sequence binding
BI350_RS05925	COG5002	protein histidine kinase activity
BI350_RS05930	COG0745	RESPONSE REGULATOR receiver
BI350_RS05940	COG1764	response to oxidative stress
BI350_RS05950	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
BI350_RS05955	COG1510	regulation of RNA biosynthetic process
BI350_RS05960	COG0517	IMP dehydrogenase activity
BI350_RS05960	COG4175	Glycine betaine
BI350_RS05965	COG4176	ABC-type proline glycine betaine transport system permease component
BI350_RS05970	COG2113	Glycine betaine
BI350_RS05975	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BI350_RS05975	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BI350_RS05980	COG0307	riboflavin synthase, alpha
BI350_RS05990	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
BI350_RS05995	COG2807	transmembrane transport
BI350_RS06010	COG2764	glyoxalase bleomycin resistance protein dioxygenase
BI350_RS06025	COG1164	Oligoendopeptidase f
BI350_RS06075	COG1301	dicarboxylic acid transport
BI350_RS06085	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BI350_RS06090	COG1024	Enoyl-CoA hydratase
BI350_RS06100	COG0318	PFAM AMP-dependent synthetase and ligase
BI350_RS06105	COG0318	PFAM AMP-dependent synthetase and ligase
BI350_RS06110	COG0183	Belongs to the thiolase family
BI350_RS06120	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BI350_RS06135	COG0588	phosphoglycerate mutase activity
BI350_RS06140	COG0778	Nitroreductase
BI350_RS06145	COG2223	nitrite transmembrane transporter activity
BI350_RS06150	COG2814	Major facilitator Superfamily
BI350_RS06160	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BI350_RS06180	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BI350_RS06185	COG1309	transcriptional regulator
BI350_RS06195	COG0420	3'-5' exonuclease activity
BI350_RS06200	COG0419	ATPase involved in DNA repair
BI350_RS06205	COG1114	Component of the transport system for branched-chain amino acids
BI350_RS06210	COG1966	Carbon starvation protein
BI350_RS06215	COG1802	Transcriptional regulator
BI350_RS06225	COG1690	Belongs to the RtcB family
BI350_RS06235	COG1388	LysM domain
BI350_RS06235	COG3584	3D domain protein
BI350_RS06245	COG1028	Short-chain dehydrogenase reductase Sdr
BI350_RS06250	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
BI350_RS06255	COG1242	4 iron, 4 sulfur cluster binding
BI350_RS06260	COG2814	Major facilitator Superfamily
BI350_RS06265	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
BI350_RS06270	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
BI350_RS06280	COG2081	HI0933 family
BI350_RS06285	COG2244	polysaccharide biosynthetic process
BI350_RS06290	COG1187	pseudouridine synthase activity
BI350_RS06295	COG1349	DNA-binding transcription factor activity
BI350_RS06310	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BI350_RS06320	COG1363	Peptidase, m42
BI350_RS06325	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
BI350_RS06335	COG4848	Belongs to the UPF0354 family
BI350_RS06340	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BI350_RS06345	COG1674	ftsk spoiiie
BI350_RS06355	COG4980	gas vesicle protein
BI350_RS06360	COG1605	Chorismate mutase
BI350_RS06360	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
BI350_RS06375	COG0123	including yeast histone deacetylase and acetoin utilization protein
BI350_RS06380	COG0517	IMP dehydrogenase activity
BI350_RS06385	COG0454	-acetyltransferase
BI350_RS06390	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BI350_RS06395	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BI350_RS06400	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BI350_RS06405	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BI350_RS06410	COG2135	peptidase activity
BI350_RS06425	COG1956	GAF domain-containing protein
BI350_RS06430	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
BI350_RS06435	COG1104	cysteine desulfurase activity
BI350_RS06455	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BI350_RS06460	COG2962	Rard protein
BI350_RS06465	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BI350_RS06470	COG0616	signal peptide processing
BI350_RS06475	COG1714	RDD family
BI350_RS06480	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
BI350_RS06485	COG0827	DNA restriction-modification system
BI350_RS06490	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
BI350_RS06495	COG0589	response to stress
BI350_RS06500	COG0686	Belongs to the AlaDH PNT family
BI350_RS06505	COG0006	proline dipeptidase activity
BI350_RS06515	COG4109	DRTGG domain
BI350_RS06525	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
BI350_RS06530	COG0587	DNA-directed DNA polymerase activity
BI350_RS06535	COG1725	Transcriptional regulator
BI350_RS06545	COG0825	malonyl-CoA metabolic process
BI350_RS06550	COG0205	6-phosphofructokinase activity
BI350_RS06560	COG3030	protein affecting phage T7 exclusion by the F plasmid
BI350_RS06570	COG0372	Belongs to the citrate synthase family
BI350_RS06575	COG0538	isocitrate dehydrogenase activity
BI350_RS06590	COG0745	RESPONSE REGULATOR receiver
BI350_RS06595	COG5002	protein histidine kinase activity
BI350_RS06600	COG0330	HflC and HflK could
BI350_RS06605	COG0330	HflC and HflK could
BI350_RS06610	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BI350_RS06610	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BI350_RS06615	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BI350_RS06625	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BI350_RS06635	COG3611	Membrane attachment protein
BI350_RS06640	COG1484	DNA-dependent DNA replication
BI350_RS06645	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BI350_RS06655	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BI350_RS06660	COG0291	Belongs to the bacterial ribosomal protein bL35 family
BI350_RS06670	COG3326	Membrane
BI350_RS06680	COG0756	dUTP diphosphatase activity
BI350_RS06685	COG1966	Carbon starvation protein
BI350_RS06695	COG0003	Pfam Anion-transporting ATPase
BI350_RS06700	COG0604	alcohol dehydrogenase
BI350_RS06710	COG2759	Belongs to the formate--tetrahydrofolate ligase family
BI350_RS06715	COG5001	Diguanylate cyclase
BI350_RS06715	COG3300	MHYT domain
BI350_RS06720	COG4682	membrane
BI350_RS06730	COG0492	ferredoxin-NADP+ reductase activity
BI350_RS06740	COG1725	Transcriptional regulator
BI350_RS06745	COG0726	polysaccharide deacetylase
BI350_RS06760	COG0514	ATP-dependent DNA helicase (RecQ)
BI350_RS06765	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BI350_RS06780	COG1363	Peptidase, m42
BI350_RS06785	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
BI350_RS06790	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
BI350_RS06795	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
BI350_RS06800	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BI350_RS06805	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
BI350_RS06810	COG3344	reverse transcriptase
BI350_RS06820	COG1476	TRANSCRIPTIONal
BI350_RS06840	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BI350_RS06850	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BI350_RS06850	COG0072	phenylalanine-tRNA ligase activity
BI350_RS06865	COG0697	spore germination
BI350_RS06870	COG0788	formyltetrahydrofolate deformylase activity
BI350_RS06880	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
BI350_RS06890	COG1796	DNA polymerase
BI350_RS06890	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
BI350_RS06895	COG1193	negative regulation of DNA recombination
BI350_RS06900	COG3766	membrane
BI350_RS06905	COG0318	PFAM AMP-dependent synthetase and ligase
BI350_RS06910	COG1309	transcriptional regulator
BI350_RS06915	COG1024	Enoyl-CoA hydratase
BI350_RS06920	COG2086	electron transfer activity
BI350_RS06925	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
BI350_RS06930	COG3118	belongs to the thioredoxin family
BI350_RS06940	COG0527	aspartate kinase activity
BI350_RS06945	COG1719	4-vinyl reductase, 4VR
BI350_RS06950	COG2009	succinate dehydrogenase
BI350_RS06955	COG1053	succinate dehydrogenase
BI350_RS06960	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BI350_RS06965	COG0824	Thioesterase
BI350_RS06970	COG2197	response regulator
BI350_RS06975	COG1846	Transcriptional regulator
BI350_RS06985	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
BI350_RS06995	COG0622	Phosphoesterase
BI350_RS07000	COG2322	membrane
BI350_RS07010	COG0251	oxidation-reduction process
BI350_RS07065	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
BI350_RS07080	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BI350_RS07095	COG2234	aminopeptidase activity
BI350_RS07100	COG2234	aminopeptidase activity
BI350_RS07110	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BI350_RS07115	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
BI350_RS07120	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BI350_RS07130	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BI350_RS07135	COG1960	acyl-CoA dehydrogenase activity
BI350_RS07140	COG1309	transcriptional regulator
BI350_RS07145	COG1250	3-hydroxyacyl-CoA dehydrogenase
BI350_RS07155	COG2045	Belongs to the ComB family
BI350_RS07165	COG1028	Short-chain dehydrogenase reductase Sdr
BI350_RS07170	COG0318	PFAM AMP-dependent synthetase and ligase
BI350_RS07175	COG1960	acyl-CoA dehydrogenase activity
BI350_RS07185	COG2030	dehydratase
BI350_RS07195	COG0183	Belongs to the thiolase family
BI350_RS07205	COG1960	acyl-CoA dehydrogenase activity
BI350_RS07210	COG0183	Belongs to the thiolase family
BI350_RS07255	COG3290	protein histidine kinase activity
BI350_RS07260	COG4565	transcriptional regulatory protein
BI350_RS07265	COG0471	metal ion transport
BI350_RS07270	COG1278	Cold shock
BI350_RS07275	COG2318	DinB family
BI350_RS07285	COG0477	Major facilitator Superfamily
BI350_RS07290	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BI350_RS07330	COG1876	peptidase activity
BI350_RS07340	COG0305	Participates in initiation and elongation during chromosome replication
BI350_RS07355	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BI350_RS07400	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
BI350_RS07410	COG2801	Transposase and inactivated derivatives
BI350_RS07415	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
BI350_RS07420	COG1984	allophanate hydrolase subunit 2
BI350_RS07425	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
BI350_RS07430	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
BI350_RS07445	COG1846	Transcriptional regulator
BI350_RS07450	COG0778	Nitroreductase
BI350_RS07460	COG1012	belongs to the aldehyde dehydrogenase family
BI350_RS07485	COG1473	amidohydrolase
BI350_RS07495	COG2271	Major facilitator Superfamily
BI350_RS07500	COG1473	amidohydrolase
BI350_RS07510	COG2814	Major facilitator Superfamily
BI350_RS07520	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
BI350_RS07580	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BI350_RS07580	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BI350_RS07585	COG0066	3-isopropylmalate dehydratase activity
BI350_RS07590	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
BI350_RS07600	COG3976	FMN-binding domain protein
BI350_RS07600	COG1053	succinate dehydrogenase
BI350_RS07605	COG1335	isochorismatase
BI350_RS07610	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BI350_RS07625	COG4214	carbohydrate transport
BI350_RS07630	COG0411	ABC transporter
BI350_RS07640	COG1414	Transcriptional regulator
BI350_RS07650	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BI350_RS07655	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BI350_RS07660	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BI350_RS07675	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BI350_RS07690	COG0045	succinate-CoA ligase (ADP-forming) activity
BI350_RS07690	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BI350_RS07690	COG1042	CoA-binding domain protein
BI350_RS07705	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BI350_RS07715	COG1960	acyl-CoA dehydrogenase activity
BI350_RS07720	COG1960	acyl-CoA dehydrogenase activity
BI350_RS07725	COG1012	belongs to the aldehyde dehydrogenase family
BI350_RS07745	COG2801	Transposase and inactivated derivatives
BI350_RS07750	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BI350_RS07755	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BI350_RS07765	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
BI350_RS07765	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BI350_RS07770	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BI350_RS07790	COG0010	Belongs to the arginase family
BI350_RS07795	COG2986	histidine ammonia-lyase
BI350_RS07800	COG1228	amidohydrolase
BI350_RS07805	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
BI350_RS07810	COG2207	Transcriptional regulator
BI350_RS07815	COG3314	Sporulation integral membrane protein YlbJ
BI350_RS07820	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BI350_RS07825	COG1960	acyl-CoA dehydrogenase activity
BI350_RS07835	COG1278	Cold shock
BI350_RS07845	COG0789	Transcriptional regulator
BI350_RS07850	COG2199	diguanylate cyclase activity
BI350_RS07850	COG2200	EAL domain
BI350_RS07855	COG0577	efflux transmembrane transporter activity
BI350_RS07860	COG1136	(ABC) transporter
BI350_RS07865	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
BI350_RS07875	COG1028	Short-chain dehydrogenase reductase Sdr
BI350_RS07895	COG1473	amidohydrolase
BI350_RS07905	COG4948	Mandelate Racemase Muconate Lactonizing
BI350_RS07910	COG3949	Membrane
BI350_RS07930	COG0583	DNA-binding transcription factor activity
BI350_RS07935	COG1028	Short-chain dehydrogenase reductase Sdr
BI350_RS07940	COG0179	Fumarylacetoacetate (FAA) hydrolase
BI350_RS07950	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BI350_RS07955	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BI350_RS07960	COG0318	PFAM AMP-dependent synthetase and ligase
BI350_RS07965	COG0511	ligase activity, forming carbon-carbon bonds
BI350_RS07970	COG1024	Enoyl-CoA hydratase
BI350_RS07975	COG1028	Short-chain dehydrogenase reductase Sdr
BI350_RS07980	COG2030	dehydratase
BI350_RS07980	COG1012	belongs to the aldehyde dehydrogenase family
BI350_RS08055	COG0747	negative chemotaxis
BI350_RS08065	COG1175	transmembrane transport
BI350_RS08090	COG1473	amidohydrolase
BI350_RS08095	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
BI350_RS08100	COG1473	amidohydrolase
BI350_RS08105	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BI350_RS08110	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BI350_RS08115	COG0720	synthase
BI350_RS08120	COG0602	queuosine metabolic process
BI350_RS08135	COG0473	3-isopropylmalate dehydrogenase activity
BI350_RS08140	COG0300	oxidoreductase activity
BI350_RS08145	COG0405	Gamma-glutamyltransferase
BI350_RS08150	COG0583	DNA-binding transcription factor activity
BI350_RS08155	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
BI350_RS08160	COG2814	Major facilitator Superfamily
BI350_RS08165	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
BI350_RS08170	COG3383	formate dehydrogenase (NAD+) activity
BI350_RS08175	COG2427	Protein of unknown function (DUF1641)
BI350_RS08185	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BI350_RS08190	COG0154	amidase activity
BI350_RS08205	COG3243	poly(R)-hydroxyalkanoic acid synthase
BI350_RS08210	COG1028	Short-chain dehydrogenase reductase Sdr
BI350_RS08230	COG1028	Short-chain dehydrogenase reductase Sdr
BI350_RS08240	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
BI350_RS08240	COG4451	ribulose bisphosphate carboxylase, small
BI350_RS08265	COG1012	belongs to the aldehyde dehydrogenase family
BI350_RS08270	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BI350_RS08275	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BI350_RS08290	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BI350_RS08300	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BI350_RS08305	COG1116	anion transmembrane transporter activity
BI350_RS08310	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BI350_RS08320	COG0475	glutathione-regulated potassium exporter activity
BI350_RS08320	COG0589	response to stress
BI350_RS08325	COG3104	oligopeptide transport
BI350_RS08335	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
BI350_RS08340	COG1028	Short-chain dehydrogenase reductase Sdr
BI350_RS08360	COG5337	Spore coat protein CotH
BI350_RS08385	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
BI350_RS08390	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
BI350_RS08395	COG0598	Magnesium transport protein CorA
BI350_RS08400	COG0328	RNA-DNA hybrid ribonuclease activity
BI350_RS08405	COG4807	Protein conserved in bacteria
BI350_RS08410	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BI350_RS08420	COG3594	Acyltransferase
BI350_RS08445	COG2321	neutral zinc metallopeptidase
BI350_RS08460	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BI350_RS08490	COG0659	secondary active sulfate transmembrane transporter activity
BI350_RS08500	COG0477	Major facilitator Superfamily
BI350_RS08505	COG5632	N-Acetylmuramoyl-L-alanine amidase
BI350_RS08505	COG3409	Peptidoglycan-binding domain 1 protein
BI350_RS08525	COG0544	peptidyl-prolyl cis-trans isomerase activity
BI350_RS08535	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
BI350_RS08540	COG0218	Necessary for normal cell division and for the maintenance of normal septation
BI350_RS08550	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BI350_RS08565	COG0113	porphobilinogen synthase activity
BI350_RS08580	COG0525	valine-tRNA ligase activity
BI350_RS08590	COG3246	L-lysine catabolic process to acetate
BI350_RS08595	COG1250	3-hydroxyacyl-CoA dehydrogenase
BI350_RS08600	COG1250	3-hydroxyacyl-CoA dehydrogenase
BI350_RS08600	COG0824	Thioesterase
BI350_RS08630	COG0189	ligase activity
BI350_RS08635	COG0285	dihydrofolate synthase activity
BI350_RS08640	COG3706	GGDEF domain
BI350_RS08655	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BI350_RS08690	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
BI350_RS08700	COG0424	maF-like protein
BI350_RS08705	COG2003	Belongs to the UPF0758 family
BI350_RS08710	COG1077	Cell shape determining protein MreB Mrl
BI350_RS08715	COG1792	Involved in formation and maintenance of cell shape
BI350_RS08720	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
BI350_RS08725	COG0850	regulation of cytokinetic process
BI350_RS08730	COG2894	cell division
BI350_RS08740	COG1994	Peptidase M50
BI350_RS08740	COG0517	IMP dehydrogenase activity
BI350_RS08750	COG2868	ribosomal protein
BI350_RS08755	COG0211	Belongs to the bacterial ribosomal protein bL27 family
BI350_RS08765	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BI350_RS08775	COG0077	Prephenate dehydratase
BI350_RS08815	COG0343	queuine tRNA-ribosyltransferase activity
BI350_RS08820	COG1862	Preprotein translocase
BI350_RS08825	COG2323	membrane
BI350_RS08835	COG3711	transcriptional antiterminator
BI350_RS08840	COG2190	(PTS) system
BI350_RS08840	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BI350_RS08840	COG1263	PTS System
BI350_RS08855	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BI350_RS08855	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BI350_RS08860	COG5416	Lipopolysaccharide assembly protein A domain
BI350_RS08865	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
BI350_RS08865	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
BI350_RS08870	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BI350_RS08875	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BI350_RS08885	COG3103	Sh3 type 3 domain protein
BI350_RS08885	COG0860	N-Acetylmuramoyl-L-alanine amidase
BI350_RS08885	COG4991	sh3 domain protein
BI350_RS08895	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
BI350_RS08905	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
BI350_RS08915	COG4176	ABC-type proline glycine betaine transport system permease component
BI350_RS08920	COG4175	Glycine betaine
BI350_RS08920	COG3448	diguanylate cyclase activity
BI350_RS08925	COG0318	PFAM AMP-dependent synthetase and ligase
BI350_RS08930	COG0281	malic enzyme
BI350_RS08940	COG2224	Isocitrate lyase
BI350_RS08945	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
BI350_RS08950	COG1380	Effector of murein hydrolase LrgA
BI350_RS08955	COG1346	cytolysis
BI350_RS08960	COG0840	transmembrane signaling receptor activity
BI350_RS08965	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BI350_RS08975	COG1752	Esterase of the alpha-beta hydrolase superfamily
BI350_RS08995	COG1971	Probably functions as a manganese efflux pump
BI350_RS09000	COG3377	Domain of unknown function (DUF1805)
BI350_RS09005	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BI350_RS09015	COG2011	ABC-type metal ion transport system permease component
BI350_RS09020	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BI350_RS09025	COG0517	IMP dehydrogenase activity
BI350_RS09025	COG4175	Glycine betaine
BI350_RS09030	COG4176	ABC-type proline glycine betaine transport system permease component
BI350_RS09050	COG0109	protoheme IX farnesyltransferase activity
BI350_RS09055	COG0753	catalase activity
BI350_RS09065	COG0154	amidase activity
BI350_RS09070	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
BI350_RS09100	COG3104	oligopeptide transport
BI350_RS09110	COG0450	alkyl hydroperoxide reductase
BI350_RS09125	COG1131	(ABC) transporter
BI350_RS09130	COG0488	(ABC) transporter
BI350_RS09135	COG1413	lyase activity
BI350_RS09140	COG1413	lyase activity
BI350_RS09155	COG2136	Putative SAM-dependent methyltransferase
BI350_RS09155	COG2521	methyltransferase
BI350_RS09175	COG1272	protein, Hemolysin III
BI350_RS09180	COG1307	EDD domain protein, DegV family
BI350_RS09185	COG2755	lipolytic protein G-D-S-L family
BI350_RS09195	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BI350_RS09210	COG0813	purine-nucleoside phosphorylase activity
BI350_RS09215	COG0793	Belongs to the peptidase S41A family
BI350_RS09215	COG3409	Peptidoglycan-binding domain 1 protein
BI350_RS09220	COG0523	cobalamin synthesis protein
BI350_RS09225	COG2340	Cysteine-rich secretory protein family
BI350_RS09230	COG0534	Mate efflux family protein
BI350_RS09235	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BI350_RS09240	COG0567	Dehydrogenase, E1 component
BI350_RS09245	COG0508	dehydrogenase complex catalyzes the overall conversion of
BI350_RS09255	COG0714	Associated with various cellular activities
BI350_RS09260	COG4548	von Willebrand factor, type A
BI350_RS09265	COG3853	Toxic anion resistance protein (TelA)
BI350_RS09280	COG1278	Cold shock
BI350_RS09295	COG0488	(ABC) transporter
BI350_RS09300	COG2807	transmembrane transport
BI350_RS09305	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BI350_RS09315	COG0628	permease
BI350_RS09320	COG0535	radical SAM domain protein
BI350_RS09355	COG3339	Conserved Protein
BI350_RS09360	COG1802	Transcriptional regulator
BI350_RS09365	COG1063	alcohol dehydrogenase
BI350_RS09380	COG0697	spore germination
BI350_RS09385	COG3858	chitin binding
BI350_RS09385	COG1388	LysM domain
BI350_RS09400	COG1304	FMN binding
BI350_RS09440	COG1113	amino acid transport
BI350_RS09445	COG0436	Aminotransferase
BI350_RS09485	COG0157	Belongs to the NadC ModD family
BI350_RS09490	COG2358	TRAP transporter, solute receptor (TAXI family
BI350_RS09540	COG2323	membrane
BI350_RS09555	COG1929	Belongs to the glycerate kinase type-1 family
BI350_RS09570	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BI350_RS09575	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BI350_RS09610	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BI350_RS09615	COG0187	DNA topoisomerase II activity
BI350_RS09620	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
BI350_RS09625	COG4841	protein insertion into membrane
BI350_RS09635	COG0824	Thioesterase
BI350_RS09640	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
BI350_RS09645	COG1335	isochorismatase
BI350_RS09660	COG1999	signal sequence binding
BI350_RS09670	COG4846	Membrane protein involved in cytochrome C biogenesis
BI350_RS09680	COG0785	Cytochrome C biogenesis protein
BI350_RS09690	COG1132	(ABC) transporter
BI350_RS09695	COG1132	(ABC) transporter
BI350_RS09700	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BI350_RS09705	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BI350_RS09725	COG0300	oxidoreductase activity
BI350_RS09730	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BI350_RS09735	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BI350_RS09740	COG1902	pentaerythritol trinitrate reductase activity
BI350_RS09745	COG5646	InterPro IPR014922
BI350_RS09750	COG1234	tRNA 3'-trailer cleavage
BI350_RS09755	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BI350_RS09760	COG0835	chemotaxis
BI350_RS09765	COG2195	Cleaves the N-terminal amino acid of tripeptides
BI350_RS09770	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BI350_RS09775	COG0346	lactoylglutathione lyase activity
BI350_RS09790	COG2239	Acts as a magnesium transporter
BI350_RS09805	COG1703	isobutyryl-CoA mutase activity
BI350_RS09810	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BI350_RS09810	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BI350_RS09820	COG0508	dehydrogenase complex catalyzes the overall conversion of
BI350_RS09825	COG0022	dehydrogenase e1 component
BI350_RS09830	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BI350_RS09835	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BI350_RS09840	COG3426	butyrate kinase activity
BI350_RS09850	COG0280	phosphate acetyltransferase
BI350_RS09855	COG3829	transcription factor binding
BI350_RS09855	COG3290	protein histidine kinase activity
BI350_RS09870	COG0750	zinc metalloprotease
BI350_RS09875	COG0497	DNA recombination
BI350_RS09880	COG1438	arginine binding
BI350_RS09885	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
BI350_RS09890	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BI350_RS09895	COG0142	geranyltranstransferase activity
BI350_RS09920	COG1302	Protein conserved in bacteria
BI350_RS09925	COG0439	Biotin carboxylase
BI350_RS09930	COG0511	ligase activity, forming carbon-carbon bonds
BI350_RS09960	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BI350_RS09965	COG0006	proline dipeptidase activity
BI350_RS09970	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
BI350_RS09980	COG3872	metal-dependent enzyme
BI350_RS09985	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BI350_RS10010	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BI350_RS10020	COG1126	abc transporter atp-binding protein
BI350_RS10025	COG0765	amino acid transport
BI350_RS10030	COG0765	amino acid transport
BI350_RS10040	COG1960	acyl-CoA dehydrogenase activity
BI350_RS10045	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BI350_RS10055	COG0404	The glycine cleavage system catalyzes the degradation of glycine
BI350_RS10075	COG4537	Required for transformation and DNA binding
BI350_RS10080	COG1459	type II secretion system
BI350_RS10085	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BI350_RS10095	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BI350_RS10110	COG1368	sulfuric ester hydrolase activity
BI350_RS10120	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BI350_RS10125	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BI350_RS10140	COG0768	penicillin binding
BI350_RS10145	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BI350_RS10155	COG2839	Protein conserved in bacteria
BI350_RS10175	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
BI350_RS10180	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
BI350_RS10185	COG0735	belongs to the Fur family
BI350_RS10190	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BI350_RS10195	COG1121	(ABC) transporter
BI350_RS10225	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
BI350_RS10230	COG2384	SAM-dependent methyltransferase
BI350_RS10235	COG2010	Cytochrome c
BI350_RS10240	COG1960	acyl-CoA dehydrogenase activity
BI350_RS10250	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BI350_RS10255	COG0358	DNA primase activity
BI350_RS10265	COG0517	IMP dehydrogenase activity
BI350_RS10275	COG1381	Involved in DNA repair and RecF pathway recombination
BI350_RS10290	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
BI350_RS10300	COG1480	7TM receptor with intracellular HD hydrolase
BI350_RS10305	COG1702	phosphate starvation-inducible protein PhoH
BI350_RS10325	COG4864	UPF0365 protein
BI350_RS10330	COG1030	water channel activity
BI350_RS10345	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
BI350_RS10350	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BI350_RS10370	COG1395	domain, Protein
BI350_RS10395	COG2856	Zn peptidase
BI350_RS10410	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BI350_RS10415	COG2264	protein methyltransferase activity
BI350_RS10430	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BI350_RS10440	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BI350_RS10445	COG0481	GTPase activity
BI350_RS10455	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
BI350_RS10465	COG1466	dna polymerase III delta subunit
BI350_RS10475	COG0658	competence protein
BI350_RS10475	COG2333	competence protein COMEC
BI350_RS10480	COG2131	deaminase
BI350_RS10485	COG1555	photosystem II stabilization
BI350_RS10485	COG1596	polysaccharide export
BI350_RS10490	COG2226	methyltransferase
BI350_RS10495	COG0799	negative regulation of ribosome biogenesis
BI350_RS10500	COG1713	HD superfamily hydrolase involved in NAD metabolism
BI350_RS10505	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BI350_RS10510	COG1534	Rna-binding protein
BI350_RS10520	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
BI350_RS10525	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
BI350_RS10550	COG0572	uridine kinase
BI350_RS10555	COG4122	O-methyltransferase activity
BI350_RS10560	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BI350_RS10565	COG3906	Belongs to the UPF0473 family
BI350_RS10570	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
BI350_RS10575	COG4472	Bacterial protein of unknown function (DUF965)
BI350_RS10580	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BI350_RS10585	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BI350_RS10590	COG0457	Tetratricopeptide repeat
BI350_RS10595	COG0482	sulfurtransferase activity
BI350_RS10600	COG1104	cysteine desulfurase activity
BI350_RS10605	COG1959	2 iron, 2 sulfur cluster binding
BI350_RS10610	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BI350_RS10615	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BI350_RS10620	COG3842	ATPase activity
BI350_RS10625	COG1176	ABC-type spermidine putrescine transport system, permease component I
BI350_RS10630	COG0436	Aminotransferase
BI350_RS10650	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BI350_RS10675	COG0189	ligase activity
BI350_RS10685	COG1827	regulation of RNA biosynthetic process
BI350_RS10700	COG1418	mRNA catabolic process
BI350_RS10715	COG0328	RNA-DNA hybrid ribonuclease activity
BI350_RS10730	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
BI350_RS10735	COG1406	Chemotaxis phosphatase CheX
BI350_RS10740	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
BI350_RS10760	COG2814	Major facilitator Superfamily
BI350_RS10775	COG1937	Protein conserved in bacteria
BI350_RS10800	COG1525	nuclease
BI350_RS10835	COG2801	Transposase and inactivated derivatives
BI350_RS10855	COG0456	acetyltransferase
BI350_RS10875	COG3842	ATPase activity
BI350_RS10880	COG4120	Belongs to the binding-protein-dependent transport system permease family
BI350_RS10890	COG1187	pseudouridine synthase activity
BI350_RS10920	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BI350_RS10940	COG0436	Aminotransferase
BI350_RS10955	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BI350_RS10960	COG1473	amidohydrolase
BI350_RS10965	COG1288	antiporter activity
BI350_RS11025	COG2508	Transcriptional regulator
BI350_RS11045	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
BI350_RS11090	COG2801	Transposase and inactivated derivatives
BI350_RS11110	COG2514	catechol 2,3-dioxygenase activity
BI350_RS11120	COG2801	Transposase and inactivated derivatives
BI350_RS11125	COG1199	ATP-dependent helicase activity
BI350_RS11130	COG0116	Belongs to the methyltransferase superfamily
BI350_RS11140	COG3599	regulation of cell shape
BI350_RS11145	COG3359	exonuclease
BI350_RS11150	COG1205	dead DEAH box helicase
BI350_RS11150	COG1111	helicase
BI350_RS11160	COG3331	DNA recombination
BI350_RS11165	COG4499	WXG100 protein secretion system (Wss), protein YukC
BI350_RS11165	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BI350_RS11175	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BI350_RS11180	COG3935	DnaD domain protein
BI350_RS11185	COG0017	Asparaginyl-tRNA synthetase
BI350_RS11200	COG1199	ATP-dependent helicase activity
BI350_RS11200	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BI350_RS11205	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
BI350_RS11220	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
BI350_RS11220	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
BI350_RS11230	COG0438	transferase activity, transferring glycosyl groups
BI350_RS11240	COG1694	Mazg nucleotide pyrophosphohydrolase
BI350_RS11245	COG2738	Putative neutral zinc metallopeptidase
BI350_RS11250	COG4347	Protein of unknown function (DUF1405)
BI350_RS11265	COG0723	plastoquinol--plastocyanin reductase activity
BI350_RS11275	COG5582	Belongs to the UPF0302 family
BI350_RS11280	COG0457	Tetratricopeptide repeat
BI350_RS11285	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
BI350_RS11290	COG0287	Prephenate dehydrogenase
BI350_RS11295	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BI350_RS11300	COG4401	Chorismate mutase type I
BI350_RS11315	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
BI350_RS11320	COG0105	UTP biosynthetic process
BI350_RS11335	COG0142	geranyltranstransferase activity
BI350_RS11355	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
BI350_RS11375	COG1160	GTP binding
BI350_RS11380	COG0539	negative regulation of cytoplasmic translation
BI350_RS11405	COG3409	Peptidoglycan-binding domain 1 protein
BI350_RS11405	COG3773	Cell wall hydrolase
BI350_RS11410	COG2339	peptidase activity
BI350_RS11415	COG0492	ferredoxin-NADP+ reductase activity
BI350_RS11420	COG1408	metallophosphoesterase
BI350_RS11425	COG1388	LysM domain
BI350_RS11430	COG0514	ATP-dependent DNA helicase (RecQ)
BI350_RS11440	COG1141	Ferredoxin
BI350_RS11445	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
BI350_RS11455	COG1595	DNA-templated transcription, initiation
BI350_RS11460	COG5002	protein histidine kinase activity
BI350_RS11465	COG0745	RESPONSE REGULATOR receiver
BI350_RS11470	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BI350_RS11475	COG1333	cytochrome c biogenesis protein
BI350_RS11480	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BI350_RS11485	COG1187	pseudouridine synthase activity
BI350_RS11490	COG1686	Belongs to the peptidase S11 family
BI350_RS11505	COG1547	Domain of unknown function (DUF309)
BI350_RS11515	COG0019	diaminopimelate decarboxylase activity
BI350_RS11520	COG0697	spore germination
BI350_RS11525	COG1191	sigma factor activity
BI350_RS11540	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
BI350_RS11550	COG4974	Belongs to the 'phage' integrase family
BI350_RS11555	COG0735	belongs to the Fur family
BI350_RS11565	COG0494	nUDIX hydrolase
BI350_RS11570	COG0667	Aldo Keto reductase
BI350_RS11585	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BI350_RS11595	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BI350_RS11600	COG0351	phosphomethylpyrimidine kinase
BI350_RS11610	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BI350_RS11635	COG1174	glycine betaine transport
BI350_RS11695	COG1051	belongs to the nudix hydrolase family
BI350_RS11705	COG3655	Transcriptional regulator
BI350_RS11715	COG0300	oxidoreductase activity
BI350_RS11730	COG1247	-acetyltransferase
BI350_RS11735	COG1988	membrane-bound metal-dependent
BI350_RS11740	COG2322	membrane
BI350_RS11745	COG0726	polysaccharide deacetylase
BI350_RS11770	COG0708	Exodeoxyribonuclease III
BI350_RS11775	COG2153	protein acetylation
BI350_RS11780	COG1278	Cold shock
BI350_RS11820	COG2610	gluconate transmembrane transporter activity
BI350_RS11825	COG0511	ligase activity, forming carbon-carbon bonds
BI350_RS11830	COG1024	Enoyl-CoA hydratase
BI350_RS11850	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
BI350_RS11860	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BI350_RS11865	COG0697	spore germination
BI350_RS11875	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BI350_RS11880	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BI350_RS11885	COG1609	Transcriptional regulator
BI350_RS11890	COG1116	anion transmembrane transporter activity
BI350_RS11895	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
BI350_RS11910	COG0657	acetylesterase activity
BI350_RS11920	COG1757	Na H antiporter
BI350_RS11925	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
BI350_RS11965	COG0725	ABC transporter, periplasmic molybdate-binding protein
BI350_RS11970	COG4149	molybdate abc transporter
BI350_RS11975	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
BI350_RS11985	COG1114	Component of the transport system for branched-chain amino acids
BI350_RS11990	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BI350_RS11995	COG0601	transmembrane transport
BI350_RS12005	COG4608	Belongs to the ABC transporter superfamily
BI350_RS12010	COG0444	Belongs to the ABC transporter superfamily
BI350_RS12015	COG0739	heme binding
BI350_RS12030	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BI350_RS12035	COG1073	alpha beta
BI350_RS12040	COG3763	UPF0154 protein
BI350_RS12060	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
BI350_RS12075	COG1408	metallophosphoesterase
BI350_RS12080	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
BI350_RS12085	COG2860	membrane
BI350_RS12105	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
BI350_RS12120	COG4550	Control of competence regulator ComK, YlbF/YmcA
BI350_RS12125	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BI350_RS12130	COG2359	stage V sporulation protein S
BI350_RS12135	COG1692	metallophosphoesterase
BI350_RS12155	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BI350_RS12160	COG1426	Protein conserved in bacteria
BI350_RS12170	COG0300	oxidoreductase activity
BI350_RS12175	COG0612	Peptidase, M16
BI350_RS12180	COG0612	Peptidase, M16
BI350_RS12185	COG1079	Belongs to the binding-protein-dependent transport system permease family
BI350_RS12190	COG4603	Belongs to the binding-protein-dependent transport system permease family
BI350_RS12195	COG3845	ABC transporter
BI350_RS12200	COG1744	ABC transporter substrate-binding protein PnrA-like
BI350_RS12205	COG2188	Transcriptional regulator
BI350_RS12210	COG1674	ftsk spoiiie
BI350_RS12215	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
BI350_RS12225	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BI350_RS12230	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BI350_RS12245	COG0612	Peptidase, M16
BI350_RS12255	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BI350_RS12260	COG0196	riboflavin kinase activity
BI350_RS12265	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
BI350_RS12270	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
BI350_RS12275	COG1550	Protein conserved in bacteria
BI350_RS12285	COG1358	cellular component organization or biogenesis
BI350_RS12290	COG2740	Nucleic-acid-binding protein implicated in transcription termination
BI350_RS12295	COG0195	Participates in both transcription termination and antitermination
BI350_RS12305	COG2176	DNA-directed DNA polymerase activity
BI350_RS12315	COG0750	zinc metalloprotease
BI350_RS12325	COG4589	Belongs to the CDS family
BI350_RS12330	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BI350_RS12335	COG0233	cytoplasmic translational termination
BI350_RS12340	COG0528	UMP kinase activity
BI350_RS12345	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
BI350_RS12365	COG1191	sigma factor activity
BI350_RS12370	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
BI350_RS12375	COG1776	CheC inhibitor of MCP methylation
BI350_RS12380	COG0835	chemotaxis
BI350_RS12385	COG0643	Histidine kinase
BI350_RS12385	COG2198	Histidine kinase
BI350_RS12390	COG2201	protein-glutamate methylesterase activity
BI350_RS12395	COG0455	bacterial-type flagellum organization
BI350_RS12400	COG1419	protein localization to endoplasmic reticulum
BI350_RS12405	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BI350_RS12410	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BI350_RS12415	COG1684	flagellar biosynthetic protein fliR
BI350_RS12420	COG1987	bacterial-type flagellum assembly
BI350_RS12425	COG1338	Plays a role in the flagellum-specific transport system
BI350_RS12430	COG3190	flagellar
BI350_RS12435	COG2201	protein-glutamate methylesterase activity
BI350_RS12440	COG1776	CheC inhibitor of MCP methylation
BI350_RS12440	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BI350_RS12445	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BI350_RS12450	COG1580	Controls the rotational direction of flagella during chemotaxis
BI350_RS12455	COG1582	Flagellar protein (FlbD)
BI350_RS12465	COG4786	Flagellar basal body rod
BI350_RS12475	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
BI350_RS12480	COG3144	bacterial-type flagellum assembly
BI350_RS12490	COG2882	bacterial-type flagellum organization
BI350_RS12495	COG1157	protein secretion by the type III secretion system
BI350_RS12505	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BI350_RS12510	COG1766	The M ring may be actively involved in energy transduction
BI350_RS12515	COG1677	Flagellar hook-basal body complex protein FliE
BI350_RS12520	COG1558	bacterial-type flagellum-dependent cell motility
BI350_RS12525	COG1815	bacterial-type flagellum-dependent cell motility
BI350_RS12530	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
BI350_RS12535	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
BI350_RS12545	COG4974	Belongs to the 'phage' integrase family
BI350_RS12550	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BI350_RS12555	COG0758	DNA mediated transformation
BI350_RS12560	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
BI350_RS12565	COG0045	succinate-CoA ligase (ADP-forming) activity
BI350_RS12570	COG2257	FlhB HrpN YscU SpaS Family
BI350_RS12580	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BI350_RS12585	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
BI350_RS12600	COG0336	Belongs to the RNA methyltransferase TrmD family
BI350_RS12605	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BI350_RS12610	COG1837	Belongs to the UPF0109 family
BI350_RS12615	COG0228	four-way junction DNA binding
BI350_RS12620	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BI350_RS12625	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
BI350_RS12630	COG0552	protein localization to endoplasmic reticulum
BI350_RS12635	COG1196	nuclear chromosome segregation
BI350_RS12640	COG0571	ribonuclease III activity
BI350_RS12645	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BI350_RS12650	COG1028	Short-chain dehydrogenase reductase Sdr
BI350_RS12655	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
BI350_RS12660	COG0416	fatty acid biosynthetic process
BI350_RS12665	COG2050	protein possibly involved in aromatic compounds catabolism
BI350_RS12665	COG1349	DNA-binding transcription factor activity
BI350_RS12670	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BI350_RS12675	COG1760	l-serine dehydratase
BI350_RS12680	COG1760	l-serine dehydratase
BI350_RS12685	COG1461	Dihydroxyacetone kinase
BI350_RS12690	COG1302	Protein conserved in bacteria
BI350_RS12695	COG0227	Belongs to the bacterial ribosomal protein bL28 family
BI350_RS12705	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BI350_RS12710	COG1162	GTPase activity
BI350_RS12715	COG0515	serine threonine protein kinase
BI350_RS12715	COG2815	serine threonine protein kinase
BI350_RS12720	COG0631	protein serine/threonine phosphatase activity
BI350_RS12725	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BI350_RS12725	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BI350_RS12735	COG0242	peptide deformylase activity
BI350_RS12740	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BI350_RS12745	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BI350_RS12760	COG1293	RNA-binding protein homologous to eukaryotic snRNP
BI350_RS12765	COG0753	catalase activity
BI350_RS12780	COG0167	dihydroorotate dehydrogenase activity
BI350_RS12795	COG0505	Belongs to the CarA family
BI350_RS12805	COG0540	Belongs to the ATCase OTCase family
BI350_RS12815	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
BI350_RS12820	COG0564	pseudouridine synthase activity
BI350_RS12825	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BI350_RS12835	COG3599	regulation of cell shape
BI350_RS12845	COG0762	integral membrane protein
BI350_RS12850	COG1799	cell septum assembly
BI350_RS12855	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BI350_RS12865	COG1191	sigma factor activity
BI350_RS12870	COG1191	sigma factor activity
BI350_RS12880	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
BI350_RS12885	COG0849	cell division
BI350_RS12890	COG3856	small basic protein
BI350_RS12895	COG3879	Bacterial protein of unknown function (DUF881)
BI350_RS12900	COG3879	Bacterial protein of unknown function (DUF881)
BI350_RS12905	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
BI350_RS12910	COG0772	Belongs to the SEDS family
BI350_RS12915	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BI350_RS12920	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BI350_RS12925	COG0768	penicillin binding
BI350_RS12930	COG0768	penicillin binding
BI350_RS12945	COG2001	Belongs to the MraZ family
BI350_RS12960	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BI350_RS12965	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BI350_RS12970	COG0511	ligase activity, forming carbon-carbon bonds
BI350_RS12975	COG0439	Biotin carboxylase
BI350_RS12980	COG1024	Enoyl-CoA hydratase
BI350_RS12985	COG0333	Belongs to the bacterial ribosomal protein bL32 family
BI350_RS13000	COG2233	PERMEase
BI350_RS13005	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BI350_RS13010	COG3480	Lon protease (S16) C-terminal proteolytic domain
BI350_RS13020	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
BI350_RS13025	COG0742	ribosomal rna small subunit methyltransferase
BI350_RS13035	COG4471	UPF0298 protein
BI350_RS13040	COG0584	glycerophosphoryl diester phosphodiesterase
BI350_RS13045	COG3679	Belongs to the UPF0342 family
BI350_RS13050	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BI350_RS13075	COG3336	cytochrome c oxidase
BI350_RS13080	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
BI350_RS13085	COG1845	cytochrome c oxidase, subunit III
BI350_RS13115	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
BI350_RS13120	COG0772	Belongs to the SEDS family
BI350_RS13130	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
BI350_RS13135	COG4896	Protein conserved in bacteria
BI350_RS13145	COG1217	gtp-binding protein TYPA
BI350_RS13155	COG0483	inositol monophosphate 1-phosphatase activity
BI350_RS13190	COG0508	dehydrogenase complex catalyzes the overall conversion of
BI350_RS13195	COG0022	dehydrogenase e1 component
BI350_RS13210	COG0242	peptide deformylase activity
BI350_RS13220	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
BI350_RS13225	COG0569	domain protein
BI350_RS13230	COG0450	alkyl hydroperoxide reductase
BI350_RS13250	COG1176	ABC-type spermidine putrescine transport system, permease component I
BI350_RS13255	COG1177	transmembrane transport
BI350_RS13260	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
BI350_RS13265	COG2814	Major facilitator Superfamily
BI350_RS13270	COG0583	DNA-binding transcription factor activity
BI350_RS13275	COG2814	Major facilitator Superfamily
BI350_RS13280	COG0517	IMP dehydrogenase activity
BI350_RS13290	COG3300	MHYT domain
BI350_RS13290	COG5001	Diguanylate cyclase
BI350_RS13300	COG0835	chemotaxis
BI350_RS13300	COG0784	Response regulator, receiver
BI350_RS13305	COG2084	Dehydrogenase
BI350_RS13320	COG1846	Transcriptional regulator
BI350_RS13325	COG5002	protein histidine kinase activity
BI350_RS13330	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BI350_RS13335	COG0861	Integral membrane protein TerC family
BI350_RS13350	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
BI350_RS13355	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BI350_RS13360	COG1363	Peptidase, m42
BI350_RS13365	COG1012	belongs to the aldehyde dehydrogenase family
BI350_RS13375	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
BI350_RS13400	COG2358	TRAP transporter, solute receptor (TAXI family
BI350_RS13405	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
BI350_RS13410	COG2382	esterase
BI350_RS13440	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BI350_RS13465	COG2239	Acts as a magnesium transporter
BI350_RS13470	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
BI350_RS13475	COG0564	pseudouridine synthase activity
BI350_RS13485	COG2357	RelA SpoT domain protein
BI350_RS13495	COG0741	lytic transglycosylase activity
BI350_RS13500	COG2346	COG2346, Truncated hemoglobins
BI350_RS13505	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
BI350_RS13510	COG1164	Oligoendopeptidase f
BI350_RS13520	COG4862	establishment of competence for transformation
BI350_RS13525	COG1393	Belongs to the ArsC family
BI350_RS13535	COG0180	Tryptophanyl-tRNA synthetase
BI350_RS13540	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BI350_RS13545	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BI350_RS13560	COG0542	response to heat
BI350_RS13565	COG2151	metal-sulfur cluster biosynthetic enzyme
BI350_RS13570	COG1073	alpha beta
BI350_RS13575	COG0561	phosphatase activity
BI350_RS13580	COG1307	EDD domain protein, DegV family
BI350_RS13585	COG0446	pyridine nucleotide-disulphide oxidoreductase
BI350_RS13590	COG4608	Belongs to the ABC transporter superfamily
BI350_RS13595	COG0444	Belongs to the ABC transporter superfamily
BI350_RS13600	COG0601	transmembrane transport
BI350_RS13605	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BI350_RS13610	COG0747	negative chemotaxis
BI350_RS13615	COG0747	negative chemotaxis
BI350_RS13620	COG0366	Alpha amylase catalytic
BI350_RS13650	COG0398	Pfam SNARE associated Golgi protein
BI350_RS13655	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
BI350_RS13670	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BI350_RS13675	COG0793	Belongs to the peptidase S41A family
BI350_RS13675	COG3409	Peptidoglycan-binding domain 1 protein
BI350_RS13680	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BI350_RS13690	COG0739	heme binding
BI350_RS13695	COG2177	Part of the ABC transporter FtsEX involved in
BI350_RS13700	COG2884	Cell division ATP-binding protein ftsE
BI350_RS13710	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
BI350_RS13715	COG0653	protein targeting
BI350_RS13735	COG1516	flagellar protein fliS
BI350_RS13740	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
BI350_RS13745	COG1334	flagellar protein FlaG
BI350_RS13750	COG0840	transmembrane signaling receptor activity
BI350_RS13785	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
BI350_RS13785	COG0028	Belongs to the TPP enzyme family
BI350_RS13805	COG1028	Short-chain dehydrogenase reductase Sdr
BI350_RS13810	COG1083	cytidylyl-transferase
BI350_RS13820	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
BI350_RS13830	COG2089	acid synthase
BI350_RS13835	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
BI350_RS13845	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BI350_RS13865	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BI350_RS13870	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
BI350_RS13875	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
BI350_RS13885	COG1256	bacterial-type flagellum assembly
BI350_RS13885	COG4786	Flagellar basal body rod
BI350_RS13895	COG2747	anti-sigma28 factor FlgM
BI350_RS13905	COG1040	competence protein
BI350_RS13910	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
BI350_RS13915	COG1307	EDD domain protein, DegV family
BI350_RS13920	COG1024	Enoyl-CoA hydratase
BI350_RS13935	COG1506	peptidase
BI350_RS13935	COG4946	Tricorn protease homolog
BI350_RS13935	COG0823	Involved in the tonB-independent uptake of proteins
BI350_RS13940	COG0318	PFAM AMP-dependent synthetase and ligase
BI350_RS13950	COG0577	efflux transmembrane transporter activity
BI350_RS13955	COG1136	(ABC) transporter
BI350_RS13960	COG2205	protein histidine kinase activity
BI350_RS13965	COG0745	RESPONSE REGULATOR receiver
BI350_RS13970	COG0095	Lipoate-protein ligase
BI350_RS13980	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
BI350_RS13985	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
BI350_RS13990	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
BI350_RS14000	COG1473	amidohydrolase
BI350_RS14020	COG2197	response regulator
BI350_RS14025	COG4585	Histidine kinase
BI350_RS14030	COG1739	Uncharacterized protein family UPF0029
BI350_RS14035	COG1316	TRANSCRIPTIONal
BI350_RS14040	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BI350_RS14045	COG0653	protein targeting
BI350_RS14050	COG0363	glucosamine-6-phosphate deaminase activity
BI350_RS14055	COG0281	malic enzyme
BI350_RS14060	COG1114	Component of the transport system for branched-chain amino acids
BI350_RS14065	COG0659	secondary active sulfate transmembrane transporter activity
BI350_RS14075	COG0438	transferase activity, transferring glycosyl groups
BI350_RS14080	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BI350_RS14100	COG0561	phosphatase activity
BI350_RS14130	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
BI350_RS14135	COG3285	dna ligase
BI350_RS14135	COG1793	dna ligase
BI350_RS14140	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
BI350_RS14145	COG0318	PFAM AMP-dependent synthetase and ligase
BI350_RS14150	COG1012	belongs to the aldehyde dehydrogenase family
BI350_RS14155	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BI350_RS14160	COG1757	Na H antiporter
BI350_RS14170	COG3938	Belongs to the proline racemase family
BI350_RS14175	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BI350_RS14180	COG3290	protein histidine kinase activity
BI350_RS14180	COG3829	transcription factor binding
BI350_RS14205	COG1505	serine-type exopeptidase activity
BI350_RS14210	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BI350_RS14215	COG0601	transmembrane transport
BI350_RS14225	COG4608	Belongs to the ABC transporter superfamily
BI350_RS14230	COG0444	Belongs to the ABC transporter superfamily
BI350_RS14235	COG0006	proline dipeptidase activity
BI350_RS14240	COG0006	proline dipeptidase activity
BI350_RS14245	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
BI350_RS14255	COG3842	ATPase activity
BI350_RS14260	COG2508	Transcriptional regulator
BI350_RS14270	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BI350_RS14275	COG1609	Transcriptional regulator
BI350_RS14295	COG1554	hydrolase, family 65, central catalytic
BI350_RS14300	COG2801	Transposase and inactivated derivatives
BI350_RS14310	COG0166	Belongs to the GPI family
BI350_RS14315	COG0561	phosphatase activity
BI350_RS14325	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
BI350_RS14330	COG1691	(AIR) carboxylase
BI350_RS14335	COG1070	Carbohydrate kinase
BI350_RS14340	COG1028	Short-chain dehydrogenase reductase Sdr
BI350_RS14350	COG1606	tRNA processing
BI350_RS14365	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BI350_RS14380	COG2755	lipolytic protein G-D-S-L family
BI350_RS14385	COG0673	inositol 2-dehydrogenase activity
BI350_RS14390	COG5578	integral membrane protein
BI350_RS14400	COG2207	Transcriptional regulator
BI350_RS14410	COG0395	ABC-type sugar transport system, permease component
BI350_RS14415	COG4209	transmembrane transport
BI350_RS14420	COG1653	transport
BI350_RS14435	COG0483	inositol monophosphate 1-phosphatase activity
BI350_RS14450	COG1028	Short-chain dehydrogenase reductase Sdr
BI350_RS14455	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
BI350_RS14470	COG2207	Transcriptional regulator
BI350_RS14470	COG4753	response regulator
BI350_RS14475	COG2972	Histidine kinase
BI350_RS14480	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
BI350_RS14490	COG0395	ABC-type sugar transport system, permease component
BI350_RS14505	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
BI350_RS14515	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
BI350_RS14520	COG1904	glucuronate isomerase
BI350_RS14535	COG4608	Belongs to the ABC transporter superfamily
BI350_RS14540	COG0444	Belongs to the ABC transporter superfamily
BI350_RS14545	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BI350_RS14555	COG0747	negative chemotaxis
BI350_RS14560	COG0006	proline dipeptidase activity
BI350_RS14570	COG0626	cystathionine gamma-synthase activity
BI350_RS14585	COG0673	inositol 2-dehydrogenase activity
BI350_RS14595	COG0673	inositol 2-dehydrogenase activity
BI350_RS14605	COG1609	Transcriptional regulator
BI350_RS14620	COG1653	transport
BI350_RS14625	COG5578	integral membrane protein
BI350_RS14635	COG3949	Membrane
BI350_RS14640	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BI350_RS14650	COG0404	The glycine cleavage system catalyzes the degradation of glycine
BI350_RS14650	COG0446	pyridine nucleotide-disulphide oxidoreductase
BI350_RS14675	COG2323	membrane
BI350_RS14685	COG0656	L-ascorbic acid biosynthetic process
BI350_RS14690	COG3595	metallopeptidase activity
BI350_RS14700	COG1854	S-ribosylhomocysteine lyase activity
BI350_RS14705	COG0165	Argininosuccinate lyase
BI350_RS14715	COG2801	Transposase and inactivated derivatives
BI350_RS14720	COG2211	Major facilitator Superfamily
BI350_RS14740	COG1404	Belongs to the peptidase S8 family
BI350_RS14750	COG1028	Short-chain dehydrogenase reductase Sdr
BI350_RS14755	COG1473	amidohydrolase
BI350_RS14760	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BI350_RS14770	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
BI350_RS14790	COG1396	sequence-specific DNA binding
BI350_RS14795	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
BI350_RS14800	COG0535	radical SAM domain protein
BI350_RS14820	COG1404	Belongs to the peptidase S8 family
BI350_RS14830	COG1012	belongs to the aldehyde dehydrogenase family
BI350_RS14835	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BI350_RS14840	COG3775	system Galactitol-specific IIC component
BI350_RS14845	COG3414	Phosphotransferase system galactitol-specific IIB component
BI350_RS14870	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BI350_RS14870	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BI350_RS14870	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BI350_RS14875	COG1105	Belongs to the carbohydrate kinase PfkB family
BI350_RS14880	COG1349	DNA-binding transcription factor activity
BI350_RS14890	COG0318	PFAM AMP-dependent synthetase and ligase
BI350_RS14895	COG1024	Enoyl-CoA hydratase
BI350_RS14905	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BI350_RS14915	COG1113	amino acid transport
BI350_RS14920	COG1280	lysine exporter protein (LysE YggA)
BI350_RS14930	COG2814	Major facilitator Superfamily
BI350_RS14935	COG1280	lysine exporter protein (LysE YggA)
BI350_RS14945	COG1953	Uracil, thiamine, allantoin
BI350_RS14950	COG1335	isochorismatase
BI350_RS14960	COG1070	Carbohydrate kinase
BI350_RS14965	COG2115	Belongs to the xylose isomerase family
BI350_RS14970	COG4214	carbohydrate transport
BI350_RS14975	COG1129	ABC transporter
BI350_RS14980	COG4213	ABC transporter substrate-binding protein
BI350_RS14990	COG1940	carbohydrate kinase activity
BI350_RS15010	COG1414	Transcriptional regulator
BI350_RS15025	COG4608	Belongs to the ABC transporter superfamily
BI350_RS15030	COG0444	Belongs to the ABC transporter superfamily
BI350_RS15035	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BI350_RS15040	COG0601	transmembrane transport
BI350_RS15045	COG0747	negative chemotaxis
BI350_RS15050	COG4126	flavin adenine dinucleotide binding
BI350_RS15075	COG3300	MHYT domain
BI350_RS15075	COG5001	Diguanylate cyclase
BI350_RS15090	COG3871	stress protein (general stress protein 26)
BI350_RS15115	COG2801	Transposase and inactivated derivatives
BI350_RS15135	COG1361	Conserved repeat domain
BI350_RS15140	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BI350_RS15145	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BI350_RS15180	COG1316	TRANSCRIPTIONal
BI350_RS15185	COG0791	NLP P60 protein
BI350_RS15185	COG1388	LysM domain
BI350_RS15200	COG1388	LysM domain
BI350_RS15200	COG0791	NLP P60 protein
BI350_RS15205	COG2247	cell wall binding repeat
BI350_RS15205	COG0860	N-Acetylmuramoyl-L-alanine amidase
BI350_RS15225	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
BI350_RS15225	COG2755	lipolytic protein G-D-S-L family
BI350_RS15230	COG2911	Protein conserved in bacteria
BI350_RS15230	COG1361	Conserved repeat domain
BI350_RS15230	COG3266	domain, Protein
BI350_RS15240	COG1404	Belongs to the peptidase S8 family
BI350_RS15245	COG3266	domain, Protein
BI350_RS15245	COG1361	Conserved repeat domain
BI350_RS15245	COG2911	Protein conserved in bacteria
BI350_RS15255	COG4193	domain, Protein
BI350_RS15300	COG2027	D-alanyl-D-alanine carboxypeptidase
BI350_RS15305	COG0737	Belongs to the 5'-nucleotidase family
BI350_RS15325	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BI350_RS15375	COG0673	inositol 2-dehydrogenase activity
BI350_RS15425	COG0436	Aminotransferase
BI350_RS15445	COG4145	pantothenate transmembrane transporter activity
BI350_RS15460	COG2233	PERMEase
BI350_RS15490	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BI350_RS15495	COG0629	single-stranded DNA binding
BI350_RS15515	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BI350_RS15525	COG4786	Flagellar basal body rod
BI350_RS15530	COG4786	Flagellar basal body rod
BI350_RS15535	COG1077	Cell shape determining protein MreB Mrl
BI350_RS15540	COG1609	Transcriptional regulator
BI350_RS15545	COG0739	heme binding
BI350_RS15550	COG2385	sporulation resulting in formation of a cellular spore
BI350_RS15560	COG4836	Membrane
BI350_RS15575	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
BI350_RS15585	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BI350_RS15595	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BI350_RS15600	COG0356	it plays a direct role in the translocation of protons across the membrane
BI350_RS15610	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
BI350_RS15615	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
BI350_RS15620	COG2202	Pas domain
BI350_RS15620	COG2200	EAL domain
BI350_RS15620	COG2199	diguanylate cyclase activity
BI350_RS15630	COG4475	Protein of unknown function (DUF436)
BI350_RS15635	COG0698	ribose 5-phosphate isomerase
BI350_RS15640	COG0840	transmembrane signaling receptor activity
BI350_RS15645	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BI350_RS15650	COG1971	Probably functions as a manganese efflux pump
BI350_RS15655	COG0009	L-threonylcarbamoyladenylate synthase
BI350_RS15670	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BI350_RS15675	COG1435	thymidine kinase activity
BI350_RS15680	COG0254	rRNA binding
BI350_RS15685	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
BI350_RS15690	COG1494	fructose-1,6-bisphosphatase
BI350_RS15695	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BI350_RS15705	COG0191	fructose-bisphosphate aldolase activity
BI350_RS15710	COG2204	response regulator
BI350_RS15715	COG4821	SIS domain
BI350_RS15720	COG0504	CTP synthase activity
BI350_RS15725	COG3343	RNA polymerase activity
BI350_RS15730	COG1703	isobutyryl-CoA mutase activity
BI350_RS15730	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BI350_RS15730	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BI350_RS15735	COG1309	transcriptional regulator
BI350_RS15740	COG1960	acyl-CoA dehydrogenase activity
BI350_RS15745	COG1960	acyl-CoA dehydrogenase activity
BI350_RS15750	COG1250	3-hydroxyacyl-CoA dehydrogenase
BI350_RS15755	COG0183	Belongs to the thiolase family
BI350_RS15760	COG0247	lactate metabolic process
BI350_RS15760	COG2181	nitrate reductase activity
BI350_RS15775	COG2096	Adenosyltransferase
BI350_RS15795	COG1492	cobalamin metabolic process
BI350_RS15805	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BI350_RS15810	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
BI350_RS15815	COG1120	ATPase activity
BI350_RS15820	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BI350_RS15825	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BI350_RS15840	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BI350_RS15860	COG3465	dGTPase activity
BI350_RS15865	COG1078	dGTPase activity
BI350_RS15880	COG0280	phosphate acetyltransferase
BI350_RS15885	COG3253	May function as heme-dependent peroxidase
BI350_RS15890	COG3773	Cell wall hydrolase
BI350_RS15900	COG2363	Small membrane protein
BI350_RS15910	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
BI350_RS15930	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
BI350_RS15935	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
BI350_RS15940	COG3314	Sporulation integral membrane protein YlbJ
BI350_RS15945	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BI350_RS15950	COG0156	8-amino-7-oxononanoate synthase activity
BI350_RS15965	COG2364	Membrane
BI350_RS15970	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BI350_RS15975	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BI350_RS15975	COG0551	DNA topoisomerase type I activity
BI350_RS15980	COG2205	protein histidine kinase activity
BI350_RS15985	COG0745	RESPONSE REGULATOR receiver
BI350_RS16000	COG2207	Transcriptional regulator
BI350_RS16000	COG3708	Transcriptional regulator
BI350_RS16005	COG2814	Major facilitator Superfamily
BI350_RS16010	COG2217	Heavy metal translocating P-type atpase
BI350_RS16035	COG1253	flavin adenine dinucleotide binding
BI350_RS16040	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BI350_RS16065	COG1132	(ABC) transporter
BI350_RS16070	COG1132	(ABC) transporter
BI350_RS16080	COG3300	MHYT domain
BI350_RS16080	COG5001	Diguanylate cyclase
BI350_RS16085	COG2031	fatty acid transporter
BI350_RS16090	COG1028	Short-chain dehydrogenase reductase Sdr
BI350_RS16095	COG2801	Transposase and inactivated derivatives
BI350_RS16105	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
BI350_RS16110	COG1573	uracil-dna glycosylase
BI350_RS16115	COG1511	domain protein
BI350_RS16120	COG1309	transcriptional regulator
BI350_RS16135	COG1122	ATPase activity
BI350_RS16175	COG1012	belongs to the aldehyde dehydrogenase family
BI350_RS16180	COG0653	protein targeting
BI350_RS16185	COG2814	Major facilitator Superfamily
BI350_RS16190	COG1309	transcriptional regulator
BI350_RS16210	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
BI350_RS16215	COG0066	3-isopropylmalate dehydratase activity
BI350_RS16240	COG0440	acetolactate synthase activity
BI350_RS16245	COG0028	Belongs to the TPP enzyme family
BI350_RS16250	COG2801	Transposase and inactivated derivatives
BI350_RS16260	COG2801	Transposase and inactivated derivatives
BI350_RS16270	COG1012	belongs to the aldehyde dehydrogenase family
BI350_RS16275	COG1960	acyl-CoA dehydrogenase activity
BI350_RS16280	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BI350_RS16300	COG0314	molybdopterin synthase activity
BI350_RS16310	COG0303	'Molybdopterin
BI350_RS16315	COG0315	cyclic pyranopterin monophosphate synthase activity
BI350_RS16325	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BI350_RS16330	COG2223	nitrite transmembrane transporter activity
BI350_RS16340	COG2197	response regulator
BI350_RS16355	COG2181	nitrate reductase activity
BI350_RS16365	COG1140	nitrate reductase beta subunit
BI350_RS16370	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
BI350_RS16375	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BI350_RS16380	COG0716	FMN binding
BI350_RS16385	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BI350_RS16395	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BI350_RS16400	COG1115	amino acid carrier protein
BI350_RS16405	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
BI350_RS16410	COG1473	amidohydrolase
BI350_RS16415	COG1473	amidohydrolase
BI350_RS16420	COG1288	antiporter activity
BI350_RS16425	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
BI350_RS16430	COG1234	tRNA 3'-trailer cleavage
BI350_RS16445	COG3850	Histidine kinase
BI350_RS16445	COG5002	protein histidine kinase activity
BI350_RS16450	COG0745	RESPONSE REGULATOR receiver
BI350_RS16455	COG1121	(ABC) transporter
BI350_RS16460	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BI350_RS16465	COG0803	Belongs to the bacterial solute-binding protein 9 family
BI350_RS16470	COG1968	undecaprenyl-diphosphatase activity
BI350_RS16475	COG0586	Pfam SNARE associated Golgi protein
BI350_RS16485	COG0318	PFAM AMP-dependent synthetase and ligase
BI350_RS16530	COG3290	protein histidine kinase activity
BI350_RS16535	COG1668	transmembrane transport
BI350_RS16540	COG4152	abc transporter atp-binding protein