locus-tag	class	description
MCCS_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
MCCS_RS00010	COG0592	DNA-directed DNA polymerase activity
MCCS_RS00015	COG4152	abc transporter atp-binding protein
MCCS_RS00020	COG1668	transmembrane transport
MCCS_RS00025	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
MCCS_RS00030	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
MCCS_RS00035	COG2501	S4 domain
MCCS_RS00040	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
MCCS_RS00045	COG0187	DNA topoisomerase II activity
MCCS_RS00050	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
MCCS_RS00055	COG0028	Belongs to the TPP enzyme family
MCCS_RS00060	COG3527	Alpha-acetolactate decarboxylase
MCCS_RS00065	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
MCCS_RS00070	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
MCCS_RS00085	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
MCCS_RS00090	COG0359	binds to the 23S rRNA
MCCS_RS00095	COG0305	Participates in initiation and elongation during chromosome replication
MCCS_RS00100	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
MCCS_RS00105	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MCCS_RS00120	COG0745	RESPONSE REGULATOR receiver
MCCS_RS00135	COG4853	Protein conserved in bacteria
MCCS_RS00140	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
MCCS_RS00145	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
MCCS_RS00155	COG0863	Belongs to the N(4) N(6)-methyltransferase family
MCCS_RS00260	COG0135	phosphoribosylanthranilate isomerase activity
MCCS_RS00280	COG0518	GMP synthase (glutamine-hydrolyzing) activity
MCCS_RS00280	COG0519	Catalyzes the synthesis of GMP from XMP
MCCS_RS00305	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
MCCS_RS00310	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
MCCS_RS00315	COG1733	regulation of RNA biosynthetic process
MCCS_RS00320	COG1063	alcohol dehydrogenase
MCCS_RS00445	COG1876	peptidase activity
MCCS_RS00460	COG0431	NADPH-dependent FMN reductase
MCCS_RS00475	COG0535	radical SAM domain protein
MCCS_RS00485	COG0582	viral genome integration into host DNA
MCCS_RS00490	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
MCCS_RS00490	COG2111	Na H antiporter
MCCS_RS00495	COG2111	Na H antiporter
MCCS_RS00500	COG1006	Multisubunit Na H antiporter MnhC subunit
MCCS_RS00510	COG1863	multisubunit Na H antiporter MnhE subunit
MCCS_RS00515	COG2212	antiporter activity
MCCS_RS00520	COG1320	monovalent cation:proton antiporter activity
MCCS_RS00525	COG0702	epimerase
MCCS_RS00545	COG0431	NADPH-dependent FMN reductase
MCCS_RS00550	COG1114	Component of the transport system for branched-chain amino acids
MCCS_RS00555	COG1764	response to oxidative stress
MCCS_RS00560	COG1846	Transcriptional regulator
MCCS_RS00595	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MCCS_RS00620	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
MCCS_RS00635	COG2807	transmembrane transport
MCCS_RS00640	COG1396	sequence-specific DNA binding
MCCS_RS00645	COG0753	catalase activity
MCCS_RS00655	COG5002	protein histidine kinase activity
MCCS_RS00660	COG0523	cobalamin synthesis protein
MCCS_RS00665	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MCCS_RS00670	COG4485	Bacterial membrane protein, YfhO
MCCS_RS00675	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
MCCS_RS00715	COG1473	amidohydrolase
MCCS_RS00720	COG1396	sequence-specific DNA binding
MCCS_RS00725	COG0477	Major facilitator Superfamily
MCCS_RS00745	COG1090	epimerase
MCCS_RS00755	COG0346	lactoylglutathione lyase activity
MCCS_RS00760	COG0346	lactoylglutathione lyase activity
MCCS_RS00765	COG0346	lactoylglutathione lyase activity
MCCS_RS00770	COG0400	carboxylic ester hydrolase activity
MCCS_RS00780	COG2814	Major facilitator Superfamily
MCCS_RS00785	COG1335	isochorismatase
MCCS_RS00800	COG2814	Major facilitator Superfamily
MCCS_RS00820	COG0346	lactoylglutathione lyase activity
MCCS_RS00825	COG0400	carboxylic ester hydrolase activity
MCCS_RS00830	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
MCCS_RS00835	COG0475	glutathione-regulated potassium exporter activity
MCCS_RS00840	COG0490	domain, Protein
MCCS_RS00850	COG4841	protein insertion into membrane
MCCS_RS00860	COG0028	Belongs to the TPP enzyme family
MCCS_RS00865	COG0733	neurotransmitter:sodium symporter activity
MCCS_RS00870	COG1647	Serine aminopeptidase, S33
MCCS_RS00875	COG1113	amino acid transport
MCCS_RS00880	COG0753	catalase activity
MCCS_RS00885	COG3279	Response regulator of the LytR AlgR family
MCCS_RS00910	COG1115	amino acid carrier protein
MCCS_RS00925	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MCCS_RS00930	COG1136	(ABC) transporter
MCCS_RS00935	COG0577	efflux transmembrane transporter activity
MCCS_RS00945	COG5002	protein histidine kinase activity
MCCS_RS00945	COG3850	Histidine kinase
MCCS_RS00950	COG2326	polyphosphate kinase activity
MCCS_RS00955	COG1028	Short-chain dehydrogenase reductase Sdr
MCCS_RS00965	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MCCS_RS00980	COG2116	formate transmembrane transporter activity
MCCS_RS00985	COG0450	alkyl hydroperoxide reductase
MCCS_RS00990	COG3634	alkyl hydroperoxide reductase activity
MCCS_RS00995	COG0725	ABC transporter, periplasmic molybdate-binding protein
MCCS_RS01000	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
MCCS_RS01030	COG1131	(ABC) transporter
MCCS_RS01035	COG5646	InterPro IPR014922
MCCS_RS01040	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
MCCS_RS01055	COG3275	phosphorelay sensor kinase activity
MCCS_RS01060	COG3279	Response regulator of the LytR AlgR family
MCCS_RS01070	COG1346	cytolysis
MCCS_RS01075	COG0577	efflux transmembrane transporter activity
MCCS_RS01080	COG1136	(ABC) transporter
MCCS_RS01085	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MCCS_RS01095	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
MCCS_RS01100	COG2022	thiamine diphosphate biosynthetic process
MCCS_RS01110	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MCCS_RS01115	COG0352	thiamine-phosphate diphosphorylase activity
MCCS_RS01130	COG0861	Integral membrane protein TerC family
MCCS_RS01135	COG0586	Pfam SNARE associated Golgi protein
MCCS_RS01140	COG0672	)-iron permease
MCCS_RS01145	COG2837	iron assimilation
MCCS_RS01150	COG2822	iron ion transport
MCCS_RS01160	COG2348	transferase activity, transferring amino-acyl groups
MCCS_RS01165	COG0813	purine-nucleoside phosphorylase activity
MCCS_RS01170	COG4149	molybdate abc transporter
MCCS_RS01175	COG1960	acyl-CoA dehydrogenase activity
MCCS_RS01180	COG0697	spore germination
MCCS_RS01185	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MCCS_RS01190	COG1268	BioY protein
MCCS_RS01200	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
MCCS_RS01205	COG1140	nitrate reductase beta subunit
MCCS_RS01210	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
MCCS_RS01215	COG2181	nitrate reductase activity
MCCS_RS01225	COG4585	Histidine kinase
MCCS_RS01230	COG2197	response regulator
MCCS_RS01240	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
MCCS_RS01245	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
MCCS_RS01250	COG2205	protein histidine kinase activity
MCCS_RS01255	COG0745	RESPONSE REGULATOR receiver
MCCS_RS01265	COG2223	nitrite transmembrane transporter activity
MCCS_RS01270	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
MCCS_RS01280	COG0315	cyclic pyranopterin monophosphate synthase activity
MCCS_RS01295	COG0314	molybdopterin synthase activity
MCCS_RS01305	COG0746	molybdenum cofactor guanylyltransferase activity
MCCS_RS01310	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
MCCS_RS01315	COG3239	Fatty acid desaturase
MCCS_RS01320	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MCCS_RS01325	COG2814	Major facilitator Superfamily
MCCS_RS01335	COG1012	belongs to the aldehyde dehydrogenase family
MCCS_RS01340	COG2814	Major facilitator Superfamily
MCCS_RS01350	COG1131	(ABC) transporter
MCCS_RS01360	COG1686	Belongs to the peptidase S11 family
MCCS_RS01365	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
MCCS_RS01370	COG1620	l-lactate permease
MCCS_RS01375	COG0039	L-malate dehydrogenase activity
MCCS_RS01380	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MCCS_RS01385	COG0492	ferredoxin-NADP+ reductase activity
MCCS_RS01390	COG1120	ATPase activity
MCCS_RS01395	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MCCS_RS01400	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MCCS_RS01410	COG0366	Alpha amylase catalytic
MCCS_RS01415	COG2186	Transcriptional regulator
MCCS_RS01420	COG0247	lactate metabolic process
MCCS_RS01425	COG1139	Iron-sulfur cluster binding protein
MCCS_RS01430	COG1556	Lactate utilization protein
MCCS_RS01445	COG2348	transferase activity, transferring amino-acyl groups
MCCS_RS01450	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
MCCS_RS01460	COG2084	Dehydrogenase
MCCS_RS01465	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MCCS_RS01470	COG0436	Aminotransferase
MCCS_RS01480	COG2814	Major facilitator Superfamily
MCCS_RS01490	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
MCCS_RS01495	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
MCCS_RS01520	COG0561	phosphatase activity
MCCS_RS01530	COG0471	metal ion transport
MCCS_RS01535	COG3212	peptidase
MCCS_RS01540	COG2252	PERMEase
MCCS_RS01550	COG0051	transcription antitermination factor activity, RNA binding
MCCS_RS01555	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
MCCS_RS01560	COG0088	Forms part of the polypeptide exit tunnel
MCCS_RS01565	COG0089	rRNA binding
MCCS_RS01570	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
MCCS_RS01575	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
MCCS_RS01580	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
MCCS_RS01585	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
MCCS_RS01590	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
MCCS_RS01595	COG0255	Belongs to the universal ribosomal protein uL29 family
MCCS_RS01600	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
MCCS_RS01610	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
MCCS_RS01615	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
MCCS_RS01620	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
MCCS_RS01625	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
MCCS_RS01630	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
MCCS_RS01635	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
MCCS_RS01640	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
MCCS_RS01645	COG1841	ribosomal large subunit assembly
MCCS_RS01650	COG0200	Binds to the 23S rRNA
MCCS_RS01655	COG0201	protein transport
MCCS_RS01675	COG0257	Belongs to the bacterial ribosomal protein bL36 family
MCCS_RS01680	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
MCCS_RS01685	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
MCCS_RS01690	COG0202	RNA polymerase activity
MCCS_RS01695	COG0203	ribosomal protein L17
MCCS_RS01705	COG1122	ATPase activity
MCCS_RS01710	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
MCCS_RS01715	COG0101	tRNA pseudouridine synthase activity
MCCS_RS01720	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
MCCS_RS01725	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
MCCS_RS01790	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
MCCS_RS01800	COG2808	Putative FMN-binding domain
MCCS_RS01825	COG2249	NAD(P)H dehydrogenase (quinone) activity
MCCS_RS01830	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MCCS_RS01835	COG1733	regulation of RNA biosynthetic process
MCCS_RS01845	COG0446	pyridine nucleotide-disulphide oxidoreductase
MCCS_RS01870	COG1464	Belongs to the NlpA lipoprotein family
MCCS_RS01875	COG0039	L-malate dehydrogenase activity
MCCS_RS01895	COG0659	secondary active sulfate transmembrane transporter activity
MCCS_RS01900	COG0589	response to stress
MCCS_RS01905	COG3949	Membrane
MCCS_RS01910	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MCCS_RS01915	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
MCCS_RS01925	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MCCS_RS01925	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MCCS_RS01950	COG1937	Protein conserved in bacteria
MCCS_RS01955	COG2217	Heavy metal translocating P-type atpase
MCCS_RS01980	COG1611	Belongs to the LOG family
MCCS_RS02010	COG2814	Major facilitator Superfamily
MCCS_RS02030	COG2832	Protein of unknown function (DUF454)
MCCS_RS02035	COG1609	Transcriptional regulator
MCCS_RS02040	COG1263	PTS System
MCCS_RS02040	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MCCS_RS02040	COG2190	(PTS) system
MCCS_RS02060	COG0745	RESPONSE REGULATOR receiver
MCCS_RS02065	COG2205	protein histidine kinase activity
MCCS_RS02070	COG1136	(ABC) transporter
MCCS_RS02085	COG0574	Belongs to the PEP-utilizing enzyme family
MCCS_RS02085	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MCCS_RS02090	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
MCCS_RS02095	COG0531	amino acid
MCCS_RS02100	COG3842	ATPase activity
MCCS_RS02110	COG0395	ABC-type sugar transport system, permease component
MCCS_RS02135	COG0598	Magnesium transport protein CorA
MCCS_RS02140	COG1278	Cold shock
MCCS_RS02145	COG1278	Cold shock
MCCS_RS02200	COG1104	cysteine desulfurase activity
MCCS_RS02205	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
MCCS_RS02210	COG0157	Belongs to the NadC ModD family
MCCS_RS02215	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
MCCS_RS02225	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
MCCS_RS02240	COG0519	Catalyzes the synthesis of GMP from XMP
MCCS_RS02245	COG2814	Major facilitator Superfamily
MCCS_RS02255	COG3314	Sporulation integral membrane protein YlbJ
MCCS_RS02260	COG2329	Antibiotic biosynthesis monooxygenase
MCCS_RS02265	COG0300	oxidoreductase activity
MCCS_RS02275	COG2807	transmembrane transport
MCCS_RS02280	COG2962	Rard protein
MCCS_RS02295	COG1988	membrane-bound metal-dependent
MCCS_RS02315	COG2321	neutral zinc metallopeptidase
MCCS_RS02330	COG0489	protein tyrosine kinase activity
MCCS_RS02400	COG0010	Belongs to the arginase family
MCCS_RS02430	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MCCS_RS02435	COG0246	Mannitol dehydrogenase
MCCS_RS02440	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
MCCS_RS02445	COG3711	transcriptional antiterminator
MCCS_RS02525	COG2972	Histidine kinase
MCCS_RS02540	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
MCCS_RS02540	COG3711	transcriptional antiterminator
MCCS_RS02545	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MCCS_RS02545	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MCCS_RS02545	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
MCCS_RS02550	COG1482	cell wall glycoprotein biosynthetic process
MCCS_RS02600	COG1349	DNA-binding transcription factor activity
MCCS_RS02620	COG3842	ATPase activity
MCCS_RS02630	COG2017	converts alpha-aldose to the beta-anomer
MCCS_RS02640	COG1473	amidohydrolase
MCCS_RS02645	COG1522	sequence-specific DNA binding
MCCS_RS02645	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MCCS_RS02655	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
MCCS_RS02660	COG1802	Transcriptional regulator
MCCS_RS02665	COG2610	gluconate transmembrane transporter activity
MCCS_RS02670	COG2084	Dehydrogenase
MCCS_RS02690	COG3878	Protein conserved in bacteria
MCCS_RS02715	COG3842	ATPase activity
MCCS_RS02720	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
MCCS_RS02760	COG2391	methyltransferase activity
MCCS_RS02765	COG0425	Belongs to the sulfur carrier protein TusA family
MCCS_RS02770	COG4876	unkown
MCCS_RS02790	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
MCCS_RS02800	COG2376	Dihydroxyacetone kinase
MCCS_RS02805	COG0730	response to heat
MCCS_RS02810	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MCCS_RS02815	COG1937	Protein conserved in bacteria
MCCS_RS02820	COG0446	pyridine nucleotide-disulphide oxidoreductase
MCCS_RS02825	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MCCS_RS02825	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MCCS_RS02840	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
MCCS_RS02855	COG0579	oxidoreductase
MCCS_RS02860	COG0385	Bile acid
MCCS_RS02870	COG1012	belongs to the aldehyde dehydrogenase family
MCCS_RS02875	COG0791	NLP P60 protein
MCCS_RS02885	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
MCCS_RS02890	COG2824	Alkylphosphonate utilization operon protein PhnA
MCCS_RS02895	COG2311	Membrane
MCCS_RS02910	COG0477	Major facilitator Superfamily
MCCS_RS02925	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MCCS_RS02930	COG1392	Phosphate transport regulator
MCCS_RS02935	COG0306	phosphate transporter
MCCS_RS02950	COG0217	transcriptional regulatory protein
MCCS_RS02965	COG1725	Transcriptional regulator
MCCS_RS02970	COG1131	(ABC) transporter
MCCS_RS02990	COG2011	ABC-type metal ion transport system permease component
MCCS_RS03000	COG1309	transcriptional regulator
MCCS_RS03005	COG1566	PFAM secretion protein HlyD family protein
MCCS_RS03010	COG2814	Major facilitator Superfamily
MCCS_RS03020	COG1028	Short-chain dehydrogenase reductase Sdr
MCCS_RS03025	COG0084	hydrolase, TatD family'
MCCS_RS03030	COG0583	DNA-binding transcription factor activity
MCCS_RS03035	COG2357	RelA SpoT domain protein
MCCS_RS03040	COG2814	Major facilitator Superfamily
MCCS_RS03045	COG2839	Protein conserved in bacteria
MCCS_RS03050	COG2318	DinB family
MCCS_RS03055	COG0025	NhaP-type Na H and K H
MCCS_RS03060	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
MCCS_RS03075	COG0598	Magnesium transport protein CorA
MCCS_RS03110	COG1683	Conserved Protein
MCCS_RS03130	COG1846	Transcriptional regulator
MCCS_RS03135	COG1968	undecaprenyl-diphosphatase activity
MCCS_RS03140	COG4988	ABC transporter
MCCS_RS03145	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
MCCS_RS03160	COG0523	cobalamin synthesis protein
MCCS_RS03165	COG1349	DNA-binding transcription factor activity
MCCS_RS03170	COG1105	Belongs to the carbohydrate kinase PfkB family
MCCS_RS03175	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
MCCS_RS03175	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MCCS_RS03175	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MCCS_RS03180	COG0596	Alpha beta hydrolase
MCCS_RS03185	COG1253	flavin adenine dinucleotide binding
MCCS_RS03190	COG2814	Major facilitator Superfamily
MCCS_RS03195	COG1187	pseudouridine synthase activity
MCCS_RS03205	COG0656	L-ascorbic acid biosynthetic process
MCCS_RS03230	COG0720	synthase
MCCS_RS03235	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
MCCS_RS03240	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
MCCS_RS03240	COG0512	Glutamine amidotransferase of anthranilate synthase
MCCS_RS03260	COG1368	sulfuric ester hydrolase activity
MCCS_RS03270	COG0488	(ABC) transporter
MCCS_RS03275	COG0514	ATP-dependent DNA helicase (RecQ)
MCCS_RS03280	COG1125	glycine betaine transport
MCCS_RS03280	COG0517	IMP dehydrogenase activity
MCCS_RS03285	COG1174	glycine betaine transport
MCCS_RS03290	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MCCS_RS03295	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
MCCS_RS03300	COG1597	lipid kinase activity
MCCS_RS03305	COG3104	oligopeptide transport
MCCS_RS03310	COG3104	oligopeptide transport
MCCS_RS03315	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
MCCS_RS03325	COG1780	Probably involved in ribonucleotide reductase function
MCCS_RS03330	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MCCS_RS03335	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MCCS_RS03345	COG0812	UDP-N-acetylmuramate dehydrogenase activity
MCCS_RS03365	COG3118	belongs to the thioredoxin family
MCCS_RS03375	COG2195	Cleaves the N-terminal amino acid of tripeptides
MCCS_RS03395	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MCCS_RS03400	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MCCS_RS03405	COG1739	Uncharacterized protein family UPF0029
MCCS_RS03410	COG1307	EDD domain protein, DegV family
MCCS_RS03415	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
MCCS_RS03420	COG1040	competence protein
MCCS_RS03425	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
MCCS_RS03430	COG0653	protein targeting
MCCS_RS03435	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
MCCS_RS03440	COG2010	Cytochrome c
MCCS_RS03450	COG1388	LysM domain
MCCS_RS03450	COG3942	CHAP domain
MCCS_RS03455	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MCCS_RS03480	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
MCCS_RS03485	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
MCCS_RS03490	COG0110	maltose O-acetyltransferase activity
MCCS_RS03505	COG1660	Displays ATPase and GTPase activities
MCCS_RS03510	COG0391	Required for morphogenesis under gluconeogenic growth conditions
MCCS_RS03515	COG1481	regulation of sporulation
MCCS_RS03520	COG0740	serine-type endopeptidase activity
MCCS_RS03530	COG2390	Transcriptional regulator
MCCS_RS03535	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
MCCS_RS03540	COG0126	phosphoglycerate kinase activity
MCCS_RS03545	COG0149	triose-phosphate isomerase activity
MCCS_RS03550	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
MCCS_RS03555	COG0148	phosphopyruvate hydratase activity
MCCS_RS03560	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
MCCS_RS03565	COG1647	Serine aminopeptidase, S33
MCCS_RS03570	COG0557	exoribonuclease II activity
MCCS_RS03575	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
MCCS_RS03600	COG0710	3-dehydroquinate dehydratase activity
MCCS_RS03610	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MCCS_RS03615	COG1393	Belongs to the ArsC family
MCCS_RS03620	COG0509	glycine decarboxylation via glycine cleavage system
MCCS_RS03625	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
MCCS_RS03630	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MCCS_RS03635	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
MCCS_RS03640	COG2011	ABC-type metal ion transport system permease component
MCCS_RS03645	COG1464	Belongs to the NlpA lipoprotein family
MCCS_RS03650	COG0396	ATPase activity
MCCS_RS03655	COG0719	Fe-S assembly protein
MCCS_RS03665	COG0822	iron-sulfur transferase activity
MCCS_RS03670	COG0719	Fe-S assembly protein
MCCS_RS03680	COG0390	transport system, permease component
MCCS_RS03685	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
MCCS_RS03690	COG1801	Protein of unknown function DUF72
MCCS_RS03695	COG0730	response to heat
MCCS_RS03700	COG0737	Belongs to the 5'-nucleotidase family
MCCS_RS03705	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
MCCS_RS03710	COG4470	Protein conserved in bacteria
MCCS_RS03730	COG2445	Protein of unknown function DUF86
MCCS_RS03735	COG0647	UMP catabolic process
MCCS_RS03750	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MCCS_RS03755	COG1696	Membrane protein involved in D-alanine export
MCCS_RS03765	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
MCCS_RS03770	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
MCCS_RS03775	COG4837	Protein of unknown function (DUF1462)
MCCS_RS03780	COG1252	NADH dehydrogenase
MCCS_RS03790	COG0316	Belongs to the HesB IscA family
MCCS_RS03795	COG1252	NADH dehydrogenase
MCCS_RS03815	COG2056	Na+-H+ antiporter family
MCCS_RS03820	COG2050	protein possibly involved in aromatic compounds catabolism
MCCS_RS03825	COG1320	monovalent cation:proton antiporter activity
MCCS_RS03830	COG2212	antiporter activity
MCCS_RS03835	COG1863	multisubunit Na H antiporter MnhE subunit
MCCS_RS03855	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
MCCS_RS03855	COG2111	Na H antiporter
MCCS_RS03865	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
MCCS_RS03880	COG1098	S1 RNA binding domain
MCCS_RS03885	COG1012	belongs to the aldehyde dehydrogenase family
MCCS_RS03890	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
MCCS_RS03900	COG1979	alcohol dehydrogenase
MCCS_RS03905	COG0165	Argininosuccinate lyase
MCCS_RS03910	COG0137	argininosuccinate synthase activity
MCCS_RS03920	COG0398	Pfam SNARE associated Golgi protein
MCCS_RS03930	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
MCCS_RS03935	COG1074	ATP-dependent DNA helicase activity
MCCS_RS03955	COG1874	Beta-galactosidase
MCCS_RS03955	COG0366	Alpha amylase catalytic
MCCS_RS03965	COG0446	pyridine nucleotide-disulphide oxidoreductase
MCCS_RS03970	COG0561	phosphatase activity
MCCS_RS03975	COG2151	metal-sulfur cluster biosynthetic enzyme
MCCS_RS03980	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MCCS_RS03985	COG0542	response to heat
MCCS_RS03995	COG1744	ABC transporter substrate-binding protein PnrA-like
MCCS_RS04000	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MCCS_RS04015	COG0444	Belongs to the ABC transporter superfamily
MCCS_RS04020	COG4608	Belongs to the ABC transporter superfamily
MCCS_RS04025	COG0601	transmembrane transport
MCCS_RS04030	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MCCS_RS04040	COG1132	(ABC) transporter
MCCS_RS04045	COG0180	Tryptophanyl-tRNA synthetase
MCCS_RS04050	COG1393	Belongs to the ArsC family
MCCS_RS04055	COG4862	establishment of competence for transformation
MCCS_RS04065	COG1164	Oligoendopeptidase f
MCCS_RS04075	COG2346	COG2346, Truncated hemoglobins
MCCS_RS04090	COG2357	RelA SpoT domain protein
MCCS_RS04100	COG0564	pseudouridine synthase activity
MCCS_RS04105	COG2239	Acts as a magnesium transporter
MCCS_RS04110	COG0569	domain protein
MCCS_RS04110	COG0475	glutathione-regulated potassium exporter activity
MCCS_RS04120	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
MCCS_RS04130	COG0628	permease
MCCS_RS04135	COG1210	Utp--glucose-1-phosphate uridylyltransferase
MCCS_RS04140	COG2814	Major facilitator Superfamily
MCCS_RS04155	COG1131	(ABC) transporter
MCCS_RS04160	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
MCCS_RS04170	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
MCCS_RS04175	COG0861	Integral membrane protein TerC family
MCCS_RS04180	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MCCS_RS04185	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
MCCS_RS04190	COG3852	Histidine kinase
MCCS_RS04205	COG4873	Protein conserved in bacteria
MCCS_RS04220	COG4187	Peptidase family M20/M25/M40
MCCS_RS04225	COG3594	Acyltransferase
MCCS_RS04245	COG1316	TRANSCRIPTIONal
MCCS_RS04250	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
MCCS_RS04260	COG1682	transport, permease protein
MCCS_RS04265	COG0438	transferase activity, transferring glycosyl groups
MCCS_RS04285	COG1134	teichoic acid transport
MCCS_RS04350	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
MCCS_RS04355	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
MCCS_RS04360	COG0110	maltose O-acetyltransferase activity
MCCS_RS04365	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
MCCS_RS04370	COG1959	2 iron, 2 sulfur cluster binding
MCCS_RS04375	COG1017	nitric oxide dioxygenase activity
MCCS_RS04375	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
MCCS_RS04390	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
MCCS_RS04395	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
MCCS_RS04405	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
MCCS_RS04410	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MCCS_RS04420	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MCCS_RS04425	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
MCCS_RS04430	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
MCCS_RS04440	COG0138	bifunctional purine biosynthesis protein purh
MCCS_RS04455	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
MCCS_RS04465	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
MCCS_RS04475	COG1408	metallophosphoesterase
MCCS_RS04485	COG1271	oxidase subunit
MCCS_RS04495	COG0569	domain protein
MCCS_RS04510	COG5503	Protein of unknown function (DUF1447)
MCCS_RS04515	COG0561	phosphatase activity
MCCS_RS04525	COG0242	peptide deformylase activity
MCCS_RS04555	COG4476	Belongs to the UPF0223 family
MCCS_RS04565	COG3842	ATPase activity
MCCS_RS04575	COG1177	transmembrane transport
MCCS_RS04580	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
MCCS_RS04590	COG2427	Protein of unknown function (DUF1641)
MCCS_RS04595	COG3383	formate dehydrogenase (NAD+) activity
MCCS_RS04600	COG4493	Belongs to the UPF0637 family
MCCS_RS04605	COG0483	inositol monophosphate 1-phosphatase activity
MCCS_RS04620	COG1217	gtp-binding protein TYPA
MCCS_RS04630	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
MCCS_RS04635	COG4838	Belongs to the UPF0358 family
MCCS_RS04640	COG0772	Belongs to the SEDS family
MCCS_RS04650	COG1612	heme a metabolic process
MCCS_RS04655	COG0109	protoheme IX farnesyltransferase activity
MCCS_RS04680	COG3336	cytochrome c oxidase
MCCS_RS04690	COG0628	permease
MCCS_RS04700	COG2340	Cysteine-rich secretory protein family
MCCS_RS04705	COG3679	Belongs to the UPF0342 family
MCCS_RS04715	COG0584	glycerophosphoryl diester phosphodiesterase
MCCS_RS04730	COG0742	ribosomal rna small subunit methyltransferase
MCCS_RS04735	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
MCCS_RS04750	COG0333	Belongs to the bacterial ribosomal protein bL32 family
MCCS_RS04755	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
MCCS_RS04760	COG2001	Belongs to the MraZ family
MCCS_RS04765	COG0275	rRNA processing
MCCS_RS04770	COG4839	cell division protein FtsL
MCCS_RS04775	COG0768	penicillin binding
MCCS_RS04785	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
MCCS_RS04790	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
MCCS_RS04795	COG0849	cell division
MCCS_RS04805	COG1496	oxidoreductase activity
MCCS_RS04810	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
MCCS_RS04815	COG1799	cell septum assembly
MCCS_RS04820	COG0762	integral membrane protein
MCCS_RS04825	COG2302	S4 RNA-binding domain
MCCS_RS04830	COG3599	regulation of cell shape
MCCS_RS04835	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
MCCS_RS04840	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
MCCS_RS04845	COG0564	pseudouridine synthase activity
MCCS_RS04850	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
MCCS_RS04860	COG0540	Belongs to the ATCase OTCase family
MCCS_RS04865	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
MCCS_RS04870	COG0505	Belongs to the CarA family
MCCS_RS04875	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
MCCS_RS04885	COG0167	dihydroorotate dehydrogenase activity
MCCS_RS04890	COG0284	orotidine-5'-phosphate decarboxylase activity
MCCS_RS04895	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
MCCS_RS04905	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MCCS_RS04910	COG1523	belongs to the glycosyl hydrolase 13 family
MCCS_RS04915	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
MCCS_RS04920	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
MCCS_RS04925	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
MCCS_RS04930	COG0297	glycogen (starch) synthase activity
MCCS_RS04935	COG0058	SHG alpha-glucan phosphorylase activity
MCCS_RS04945	COG4485	Bacterial membrane protein, YfhO
MCCS_RS04955	COG1785	Belongs to the alkaline phosphatase family
MCCS_RS04975	COG0194	GDP metabolic process
MCCS_RS04980	COG1758	RNA polymerase activity
MCCS_RS04985	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
MCCS_RS04990	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
MCCS_RS05005	COG0242	peptide deformylase activity
MCCS_RS05010	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
MCCS_RS05015	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MCCS_RS05015	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
MCCS_RS05020	COG0820	rRNA (adenine-C2-)-methyltransferase activity
MCCS_RS05025	COG0631	protein serine/threonine phosphatase activity
MCCS_RS05040	COG2124	cytochrome p450
MCCS_RS05045	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MCCS_RS05055	COG3158	transport of potassium into the cell
MCCS_RS05060	COG2801	Transposase and inactivated derivatives
MCCS_RS05075	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
MCCS_RS05080	COG1564	THIamine pyrophosphokinase
MCCS_RS05085	COG0227	Belongs to the bacterial ribosomal protein bL28 family
MCCS_RS05090	COG1302	Protein conserved in bacteria
MCCS_RS05100	COG1760	l-serine dehydratase
MCCS_RS05105	COG1760	l-serine dehydratase
MCCS_RS05115	COG3764	Sortase (surface protein transpeptidase)
MCCS_RS05125	COG0416	fatty acid biosynthetic process
MCCS_RS05140	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MCCS_RS05145	COG0571	ribonuclease III activity
MCCS_RS05150	COG1196	nuclear chromosome segregation
MCCS_RS05155	COG0552	protein localization to endoplasmic reticulum
MCCS_RS05160	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
MCCS_RS05165	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
MCCS_RS05175	COG1837	Belongs to the UPF0109 family
MCCS_RS05180	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
MCCS_RS05185	COG0336	Belongs to the RNA methyltransferase TrmD family
MCCS_RS05195	COG4485	Bacterial membrane protein, YfhO
MCCS_RS05200	COG4485	Bacterial membrane protein, YfhO
MCCS_RS05210	COG0463	Glycosyl transferase, family 2
MCCS_RS05215	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
MCCS_RS05220	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
MCCS_RS05225	COG0045	succinate-CoA ligase (ADP-forming) activity
MCCS_RS05230	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
MCCS_RS05235	COG0758	DNA mediated transformation
MCCS_RS05240	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MCCS_RS05245	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
MCCS_RS05255	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
MCCS_RS05260	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
MCCS_RS05265	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
MCCS_RS05270	COG0052	Belongs to the universal ribosomal protein uS2 family
MCCS_RS05275	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
MCCS_RS05280	COG0528	UMP kinase activity
MCCS_RS05285	COG0233	cytoplasmic translational termination
MCCS_RS05295	COG4589	Belongs to the CDS family
MCCS_RS05300	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
MCCS_RS05310	COG0442	prolyl-tRNA aminoacylation
MCCS_RS05320	COG0779	Required for maturation of 30S ribosomal subunits
MCCS_RS05325	COG0195	Participates in both transcription termination and antitermination
MCCS_RS05330	COG2740	Nucleic-acid-binding protein implicated in transcription termination
MCCS_RS05335	COG1358	cellular component organization or biogenesis
MCCS_RS05340	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
MCCS_RS05345	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
MCCS_RS05350	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
MCCS_RS05355	COG0196	riboflavin kinase activity
MCCS_RS05365	COG1185	polyribonucleotide nucleotidyltransferase activity
MCCS_RS05370	COG0612	Peptidase, M16
MCCS_RS05390	COG2188	Transcriptional regulator
MCCS_RS05395	COG0612	Peptidase, M16
MCCS_RS05400	COG0612	Peptidase, M16
MCCS_RS05420	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
MCCS_RS05425	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
MCCS_RS05430	COG1418	mRNA catabolic process
MCCS_RS05435	COG1692	metallophosphoesterase
MCCS_RS05440	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
MCCS_RS05440	COG0674	pyruvate-flavodoxin oxidoreductase activity
MCCS_RS05445	COG1013	pyruvate-flavodoxin oxidoreductase activity
MCCS_RS05450	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MCCS_RS05460	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MCCS_RS05465	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MCCS_RS05465	COG1116	anion transmembrane transporter activity
MCCS_RS05470	COG0586	Pfam SNARE associated Golgi protein
MCCS_RS05475	COG1132	(ABC) transporter
MCCS_RS05480	COG1132	(ABC) transporter
MCCS_RS05485	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MCCS_RS05490	COG4550	Control of competence regulator ComK, YlbF/YmcA
MCCS_RS05495	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
MCCS_RS05500	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
MCCS_RS05510	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
MCCS_RS05515	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
MCCS_RS05520	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
MCCS_RS05530	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
MCCS_RS05535	COG1923	regulation of RNA biosynthetic process
MCCS_RS05540	COG0386	Belongs to the glutathione peroxidase family
MCCS_RS05545	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
MCCS_RS05550	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
MCCS_RS05555	COG0789	Transcriptional regulator
MCCS_RS05570	COG0527	aspartate kinase activity
MCCS_RS05575	COG0460	homoserine dehydrogenase
MCCS_RS05580	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
MCCS_RS05585	COG0083	homoserine kinase activity
MCCS_RS05590	COG0561	phosphatase activity
MCCS_RS05605	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
MCCS_RS05620	COG0833	amino acid
MCCS_RS05625	COG0267	Belongs to the bacterial ribosomal protein bL33 family
MCCS_RS05630	COG0523	cobalamin synthesis protein
MCCS_RS05660	COG3443	Belongs to the bacterial solute-binding protein 9 family
MCCS_RS05665	COG1983	PspC domain protein
MCCS_RS05680	COG4224	UPF0291 protein
MCCS_RS05690	COG3763	UPF0154 protein
MCCS_RS05700	COG0785	Cytochrome C biogenesis protein
MCCS_RS05705	COG4846	Membrane protein involved in cytochrome C biogenesis
MCCS_RS05735	COG1999	signal sequence binding
MCCS_RS05740	COG1970	mechanosensitive ion channel activity
MCCS_RS05745	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
MCCS_RS05750	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
MCCS_RS05755	COG0824	Thioesterase
MCCS_RS05760	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
MCCS_RS05765	COG0187	DNA topoisomerase II activity
MCCS_RS05770	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
MCCS_RS05775	COG1115	amino acid carrier protein
MCCS_RS05785	COG3711	transcriptional antiterminator
MCCS_RS05790	COG2190	(PTS) system
MCCS_RS05790	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MCCS_RS05790	COG1263	PTS System
MCCS_RS05795	COG0628	permease
MCCS_RS05815	COG1942	4-Oxalocrotonate Tautomerase
MCCS_RS05845	COG2161	toxin-antitoxin pair type II binding
MCCS_RS05855	COG0456	acetyltransferase
MCCS_RS05860	COG3642	lipopolysaccharide core region biosynthetic process
MCCS_RS05905	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MCCS_RS05915	COG1363	Peptidase, m42
MCCS_RS05935	COG2348	transferase activity, transferring amino-acyl groups
MCCS_RS05960	COG1028	Short-chain dehydrogenase reductase Sdr
MCCS_RS05965	COG2996	Protein conserved in bacteria
MCCS_RS05975	COG0527	aspartate kinase activity
MCCS_RS05980	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
MCCS_RS05985	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MCCS_RS05990	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
MCCS_RS06040	COG1114	Component of the transport system for branched-chain amino acids
MCCS_RS06045	COG4548	von Willebrand factor, type A
MCCS_RS06050	COG0714	Associated with various cellular activities
MCCS_RS06060	COG0346	lactoylglutathione lyase activity
MCCS_RS06075	COG5002	protein histidine kinase activity
MCCS_RS06090	COG0671	phosphoesterase, PA-phosphatase related
MCCS_RS06100	COG0793	Belongs to the peptidase S41A family
MCCS_RS06110	COG2190	(PTS) system
MCCS_RS06115	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MCCS_RS06160	COG1413	lyase activity
MCCS_RS06170	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
MCCS_RS06180	COG0561	phosphatase activity
MCCS_RS06190	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MCCS_RS06200	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
MCCS_RS06205	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
MCCS_RS06210	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
MCCS_RS06215	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MCCS_RS06220	COG0116	Belongs to the methyltransferase superfamily
MCCS_RS06230	COG3599	regulation of cell shape
MCCS_RS06235	COG4474	Belongs to the UPF0398 family
MCCS_RS06245	COG3331	DNA recombination
MCCS_RS06250	COG4499	WXG100 protein secretion system (Wss), protein YukC
MCCS_RS06250	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MCCS_RS06260	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
MCCS_RS06265	COG3935	DnaD domain protein
MCCS_RS06285	COG0617	tRNA 3'-terminal CCA addition
MCCS_RS06290	COG0438	transferase activity, transferring glycosyl groups
MCCS_RS06295	COG1694	Mazg nucleotide pyrophosphohydrolase
MCCS_RS06300	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MCCS_RS06305	COG2738	Putative neutral zinc metallopeptidase
MCCS_RS06310	COG4347	Protein of unknown function (DUF1405)
MCCS_RS06320	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
MCCS_RS06325	COG0723	plastoquinol--plastocyanin reductase activity
MCCS_RS06340	COG0457	Tetratricopeptide repeat
MCCS_RS06345	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
MCCS_RS06350	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
MCCS_RS06355	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
MCCS_RS06360	COG0105	UTP biosynthetic process
MCCS_RS06395	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
MCCS_RS06400	COG1160	GTP binding
MCCS_RS06405	COG0539	negative regulation of cytoplasmic translation
MCCS_RS06410	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
MCCS_RS06420	COG0492	ferredoxin-NADP+ reductase activity
MCCS_RS06435	COG0514	ATP-dependent DNA helicase (RecQ)
MCCS_RS06445	COG1141	Ferredoxin
MCCS_RS06460	COG0745	RESPONSE REGULATOR receiver
MCCS_RS06465	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
MCCS_RS06470	COG1333	cytochrome c biogenesis protein
MCCS_RS06475	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MCCS_RS06480	COG1187	pseudouridine synthase activity
MCCS_RS06485	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
MCCS_RS06490	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
MCCS_RS06495	COG1547	Domain of unknown function (DUF309)
MCCS_RS06500	COG4974	Belongs to the 'phage' integrase family
MCCS_RS06505	COG0735	belongs to the Fur family
MCCS_RS06510	COG0494	nUDIX hydrolase
MCCS_RS06515	COG0667	Aldo Keto reductase
MCCS_RS06520	COG1073	alpha beta
MCCS_RS06525	COG0300	oxidoreductase activity
MCCS_RS06530	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
MCCS_RS06535	COG1234	tRNA 3'-trailer cleavage
MCCS_RS06540	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
MCCS_RS06550	COG2207	Transcriptional regulator
MCCS_RS06560	COG2195	Cleaves the N-terminal amino acid of tripeptides
MCCS_RS06565	COG4129	membrane
MCCS_RS06585	COG0584	glycerophosphoryl diester phosphodiesterase
MCCS_RS06590	COG0745	RESPONSE REGULATOR receiver
MCCS_RS06595	COG0497	DNA recombination
MCCS_RS06600	COG1438	arginine binding
MCCS_RS06605	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
MCCS_RS06610	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
MCCS_RS06630	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MCCS_RS06640	COG0439	Biotin carboxylase
MCCS_RS06645	COG0511	ligase activity, forming carbon-carbon bonds
MCCS_RS06650	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
MCCS_RS06655	COG0006	proline dipeptidase activity
MCCS_RS06665	COG0095	Lipoate-protein ligase
MCCS_RS06670	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MCCS_RS06680	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
MCCS_RS06685	COG0404	The glycine cleavage system catalyzes the degradation of glycine
MCCS_RS06690	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
MCCS_RS06705	COG4537	Required for transformation and DNA binding
MCCS_RS06780	COG3953	SLT domain
MCCS_RS06780	COG5280	Phage tail tape measure protein TP901
MCCS_RS06865	COG1783	phage Terminase large subunit
MCCS_RS06870	COG5484	DNA packaging
MCCS_RS06890	COG3331	DNA recombination
MCCS_RS06895	COG0756	dUTP diphosphatase activity
MCCS_RS07015	COG1484	DNA-dependent DNA replication
MCCS_RS07075	COG1396	sequence-specific DNA binding
MCCS_RS07095	COG4974	Belongs to the 'phage' integrase family
MCCS_RS07110	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
MCCS_RS07120	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MCCS_RS07130	COG0011	TIGRFAM Protein of
MCCS_RS07135	COG1940	carbohydrate kinase activity
MCCS_RS07150	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
MCCS_RS07155	COG0267	Belongs to the bacterial ribosomal protein bL33 family
MCCS_RS07160	COG0704	Plays a role in the regulation of phosphate uptake
MCCS_RS07165	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
MCCS_RS07170	COG0581	inorganic phosphate transmembrane transporter activity
MCCS_RS07175	COG0573	inorganic phosphate transmembrane transporter activity
MCCS_RS07180	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
MCCS_RS07185	COG0768	penicillin binding
MCCS_RS07200	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
MCCS_RS07205	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
MCCS_RS07215	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MCCS_RS07220	COG1121	(ABC) transporter
MCCS_RS07225	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
MCCS_RS07230	COG0513	Belongs to the DEAD box helicase family
MCCS_RS07235	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
MCCS_RS07245	COG2384	SAM-dependent methyltransferase
MCCS_RS07250	COG2010	Cytochrome c
MCCS_RS07255	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MCCS_RS07265	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
MCCS_RS07270	COG0517	IMP dehydrogenase activity
MCCS_RS07275	COG0423	glycine-tRNA ligase activity
MCCS_RS07280	COG3844	kynureninase activity
MCCS_RS07285	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
MCCS_RS07295	COG1381	Involved in DNA repair and RecF pathway recombination
MCCS_RS07305	COG0295	cytidine deaminase activity
MCCS_RS07315	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
MCCS_RS07320	COG1702	phosphate starvation-inducible protein PhoH
MCCS_RS07335	COG4864	UPF0365 protein
MCCS_RS07340	COG1030	water channel activity
MCCS_RS07345	COG0828	Belongs to the bacterial ribosomal protein bS21 family
MCCS_RS07350	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MCCS_RS07355	COG1385	rRNA (uridine-N3-)-methyltransferase activity
MCCS_RS07360	COG2264	protein methyltransferase activity
MCCS_RS07365	COG0484	heat shock protein binding
MCCS_RS07375	COG0768	penicillin binding
MCCS_RS07390	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
MCCS_RS07395	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
MCCS_RS07405	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MCCS_RS07410	COG1121	(ABC) transporter
MCCS_RS07415	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
MCCS_RS07420	COG0513	Belongs to the DEAD box helicase family
MCCS_RS07425	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
MCCS_RS07435	COG2384	SAM-dependent methyltransferase
MCCS_RS07440	COG2010	Cytochrome c
MCCS_RS07445	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MCCS_RS07455	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
MCCS_RS07460	COG0517	IMP dehydrogenase activity
MCCS_RS07465	COG0423	glycine-tRNA ligase activity
MCCS_RS07470	COG3844	kynureninase activity
MCCS_RS07475	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
MCCS_RS07485	COG1381	Involved in DNA repair and RecF pathway recombination
MCCS_RS07495	COG0295	cytidine deaminase activity
MCCS_RS07505	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
MCCS_RS07510	COG1702	phosphate starvation-inducible protein PhoH
MCCS_RS07525	COG4864	UPF0365 protein
MCCS_RS07530	COG1030	water channel activity
MCCS_RS07535	COG0828	Belongs to the bacterial ribosomal protein bS21 family
MCCS_RS07540	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MCCS_RS07545	COG1385	rRNA (uridine-N3-)-methyltransferase activity
MCCS_RS07550	COG2264	protein methyltransferase activity
MCCS_RS07555	COG0484	heat shock protein binding
MCCS_RS07560	COG0443	Heat shock 70 kDa protein
MCCS_RS07565	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
MCCS_RS07570	COG1420	regulation of RNA biosynthetic process
MCCS_RS07575	COG0635	Involved in the biosynthesis of porphyrin-containing compound
MCCS_RS07580	COG0481	GTPase activity
MCCS_RS07585	COG0268	Binds directly to 16S ribosomal RNA
MCCS_RS07590	COG1466	dna polymerase III delta subunit
MCCS_RS07600	COG2333	competence protein COMEC
MCCS_RS07600	COG0658	competence protein
MCCS_RS07605	COG2131	deaminase
MCCS_RS07610	COG1555	photosystem II stabilization
MCCS_RS07615	COG2226	methyltransferase
MCCS_RS07620	COG0799	negative regulation of ribosome biogenesis
MCCS_RS07630	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
MCCS_RS07635	COG1534	Rna-binding protein
MCCS_RS07640	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
MCCS_RS07645	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
MCCS_RS07655	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
MCCS_RS07665	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
MCCS_RS07670	COG0572	uridine kinase
MCCS_RS07675	COG0826	peptidase U32
MCCS_RS07680	COG0826	peptidase U32
MCCS_RS07685	COG4122	O-methyltransferase activity
MCCS_RS07690	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
MCCS_RS07695	COG3906	Belongs to the UPF0473 family
MCCS_RS07700	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
MCCS_RS07705	COG4472	Bacterial protein of unknown function (DUF965)
MCCS_RS07710	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
MCCS_RS07715	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
MCCS_RS07725	COG0482	sulfurtransferase activity
MCCS_RS07730	COG1104	cysteine desulfurase activity
MCCS_RS07735	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MCCS_RS07740	COG1959	2 iron, 2 sulfur cluster binding
MCCS_RS07745	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
MCCS_RS07755	COG1131	(ABC) transporter
MCCS_RS07760	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
MCCS_RS07770	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
MCCS_RS07775	COG0124	histidyl-tRNA synthetase
MCCS_RS07780	COG0860	N-Acetylmuramoyl-L-alanine amidase
MCCS_RS07785	COG1490	D-aminoacyl-tRNA deacylase activity
MCCS_RS07790	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
MCCS_RS07795	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
MCCS_RS07800	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
MCCS_RS07800	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
MCCS_RS07805	COG1473	amidohydrolase
MCCS_RS07815	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MCCS_RS07815	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MCCS_RS07820	COG1862	Preprotein translocase
MCCS_RS07825	COG0343	queuine tRNA-ribosyltransferase activity
MCCS_RS07830	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
MCCS_RS07835	COG2255	four-way junction helicase activity
MCCS_RS07840	COG0632	four-way junction helicase activity
MCCS_RS07845	COG4492	Belongs to the UPF0735 family
MCCS_RS07850	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
MCCS_RS07860	COG0211	Belongs to the bacterial ribosomal protein bL27 family
MCCS_RS07865	COG2868	ribosomal protein
MCCS_RS07870	COG0261	This protein binds to 23S rRNA in the presence of protein L20
MCCS_RS07900	COG1132	(ABC) transporter
MCCS_RS07905	COG1132	(ABC) transporter
MCCS_RS07915	COG2003	Belongs to the UPF0758 family
MCCS_RS07920	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
MCCS_RS07925	COG1288	antiporter activity
MCCS_RS08165	COG3617	BRO family, N-terminal domain
MCCS_RS08175	COG1396	sequence-specific DNA binding
MCCS_RS08185	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
MCCS_RS08195	COG0285	dihydrofolate synthase activity
MCCS_RS08200	COG0525	valine-tRNA ligase activity
MCCS_RS08205	COG3180	Ammonia monooxygenase
MCCS_RS08215	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
MCCS_RS08230	COG0181	hydroxymethylbilane synthase activity
MCCS_RS08235	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
MCCS_RS08240	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
MCCS_RS08245	COG0218	Necessary for normal cell division and for the maintenance of normal septation
MCCS_RS08250	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
MCCS_RS08255	COG0544	peptidyl-prolyl cis-trans isomerase activity
MCCS_RS08265	COG4112	unkown
MCCS_RS08285	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
MCCS_RS08290	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
MCCS_RS08300	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
MCCS_RS08305	COG1053	succinate dehydrogenase
MCCS_RS08310	COG2009	succinate dehydrogenase
MCCS_RS08315	COG0322	excinuclease ABC activity
MCCS_RS08320	COG3118	belongs to the thioredoxin family
MCCS_RS08325	COG1193	negative regulation of DNA recombination
MCCS_RS08330	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
MCCS_RS08330	COG1796	DNA polymerase
MCCS_RS08335	COG1286	toxin biosynthetic process
MCCS_RS08340	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
MCCS_RS08345	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
MCCS_RS08350	COG0072	phenylalanine-tRNA ligase activity
MCCS_RS08355	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
MCCS_RS08380	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MCCS_RS08385	COG1846	Transcriptional regulator
MCCS_RS08390	COG3961	Belongs to the TPP enzyme family
MCCS_RS08395	COG2226	methyltransferase
MCCS_RS08405	COG5505	Protein of unknown function (DUF819)
MCCS_RS08410	COG2258	MOSC domain
MCCS_RS08420	COG1131	(ABC) transporter
MCCS_RS08425	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MCCS_RS08430	COG1304	FMN binding
MCCS_RS08445	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
MCCS_RS08445	COG1587	Uroporphyrinogen-III synthase
MCCS_RS08450	COG2146	nitrite reductase [NAD(P)H] activity
MCCS_RS08455	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MCCS_RS08460	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
MCCS_RS08460	COG1648	precorrin-2 dehydrogenase activity
MCCS_RS08470	COG2910	NAD(P)H-binding
MCCS_RS08475	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
MCCS_RS08480	COG0291	Belongs to the bacterial ribosomal protein bL35 family
MCCS_RS08485	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
MCCS_RS08490	COG0833	amino acid
MCCS_RS08495	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
MCCS_RS08500	COG1484	DNA-dependent DNA replication
MCCS_RS08505	COG3611	Membrane attachment protein
MCCS_RS08510	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
MCCS_RS08520	COG2076	Multidrug Resistance protein
MCCS_RS08525	COG2076	Multidrug Resistance protein
MCCS_RS08535	COG0237	dephospho-CoA kinase activity
MCCS_RS08540	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
MCCS_RS08545	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MCCS_RS08545	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MCCS_RS08550	COG5002	protein histidine kinase activity
MCCS_RS08555	COG0745	RESPONSE REGULATOR receiver
MCCS_RS08565	COG0538	isocitrate dehydrogenase activity
MCCS_RS08570	COG0372	Belongs to the citrate synthase family
MCCS_RS08575	COG1113	amino acid transport
MCCS_RS08580	COG0469	pyruvate kinase activity
MCCS_RS08585	COG0205	6-phosphofructokinase activity
MCCS_RS08590	COG0825	malonyl-CoA metabolic process
MCCS_RS08595	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
MCCS_RS08600	COG2186	Transcriptional regulator
MCCS_RS08605	COG0587	DNA-directed DNA polymerase activity
MCCS_RS08610	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
MCCS_RS08620	COG4109	DRTGG domain
MCCS_RS08625	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
MCCS_RS08630	COG0006	proline dipeptidase activity
MCCS_RS08640	COG0686	Belongs to the AlaDH PNT family
MCCS_RS08645	COG0589	response to stress
MCCS_RS08650	COG2226	methyltransferase
MCCS_RS08655	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
MCCS_RS08660	COG0827	DNA restriction-modification system
MCCS_RS08670	COG1714	RDD family
MCCS_RS08675	COG0616	signal peptide processing
MCCS_RS08680	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
MCCS_RS08690	COG0584	glycerophosphoryl diester phosphodiesterase
MCCS_RS08695	COG0301	tRNA thio-modification
MCCS_RS08700	COG1104	cysteine desulfurase activity
MCCS_RS08705	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
MCCS_RS08710	COG1956	GAF domain-containing protein
MCCS_RS08715	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
MCCS_RS08720	COG1764	response to oxidative stress
MCCS_RS08730	COG2986	histidine ammonia-lyase
MCCS_RS08745	COG0204	Acyl-transferase
MCCS_RS08750	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MCCS_RS08760	COG1704	LemA family
MCCS_RS08765	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
MCCS_RS08775	COG2759	Belongs to the formate--tetrahydrofolate ligase family
MCCS_RS08780	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MCCS_RS08785	COG0454	-acetyltransferase
MCCS_RS08790	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
MCCS_RS08790	COG0517	IMP dehydrogenase activity
MCCS_RS08790	COG0617	tRNA 3'-terminal CCA addition
MCCS_RS08795	COG0123	including yeast histone deacetylase and acetoin utilization protein
MCCS_RS08800	COG1609	Transcriptional regulator
MCCS_RS08805	COG1605	Chorismate mutase
MCCS_RS08805	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
MCCS_RS08815	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
MCCS_RS08820	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
MCCS_RS08825	COG1674	ftsk spoiiie
MCCS_RS08830	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MCCS_RS08835	COG4848	Belongs to the UPF0354 family
MCCS_RS08840	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MCCS_RS08850	COG1126	abc transporter atp-binding protein
MCCS_RS08855	COG0765	amino acid transport
MCCS_RS08860	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MCCS_RS08865	COG1363	Peptidase, m42
MCCS_RS08875	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
MCCS_RS08880	COG0220	tRNA (guanine-N7-)-methyltransferase activity
MCCS_RS08885	COG0510	thiamine kinase activity
MCCS_RS08890	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MCCS_RS08900	COG1187	pseudouridine synthase activity
MCCS_RS08905	COG2244	polysaccharide biosynthetic process
MCCS_RS08910	COG2081	HI0933 family
MCCS_RS08920	COG0495	leucyl-tRNA aminoacylation
MCCS_RS08925	COG2814	Major facilitator Superfamily
MCCS_RS08930	COG1242	4 iron, 4 sulfur cluster binding
MCCS_RS08935	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
MCCS_RS08945	COG2267	carboxylic ester hydrolase activity
MCCS_RS08950	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
MCCS_RS08960	COG0778	Nitroreductase
MCCS_RS09015	COG0506	proline dehydrogenase activity
MCCS_RS09020	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
MCCS_RS09030	COG0307	riboflavin synthase, alpha
MCCS_RS09035	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MCCS_RS09035	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MCCS_RS09040	COG1228	amidohydrolase
MCCS_RS09045	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
MCCS_RS09050	COG3314	Sporulation integral membrane protein YlbJ
MCCS_RS09055	COG0583	DNA-binding transcription factor activity
MCCS_RS09060	COG0010	Belongs to the arginase family
MCCS_RS09070	COG0517	IMP dehydrogenase activity
MCCS_RS09070	COG1125	glycine betaine transport
MCCS_RS09085	COG1174	glycine betaine transport
MCCS_RS09105	COG2311	Membrane
MCCS_RS09125	COG1396	sequence-specific DNA binding
MCCS_RS09135	COG1131	(ABC) transporter
MCCS_RS09190	COG0640	Transcriptional regulator
MCCS_RS09195	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MCCS_RS09215	COG1401	restriction endodeoxyribonuclease activity
MCCS_RS09230	COG4336	lyase activity
MCCS_RS09250	COG1914	H( )-stimulated, divalent metal cation uptake system
MCCS_RS09255	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
MCCS_RS09260	COG0439	Biotin carboxylase
MCCS_RS09265	COG0511	ligase activity, forming carbon-carbon bonds
MCCS_RS09270	COG1984	allophanate hydrolase subunit 2
MCCS_RS09275	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
MCCS_RS09280	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
MCCS_RS09290	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
MCCS_RS09295	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
MCCS_RS09300	COG0737	Belongs to the 5'-nucleotidase family
MCCS_RS09310	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
MCCS_RS09325	COG2801	Transposase and inactivated derivatives
MCCS_RS09330	COG1506	peptidase
MCCS_RS09335	COG0494	nUDIX hydrolase
MCCS_RS09345	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
MCCS_RS09355	COG0318	PFAM AMP-dependent synthetase and ligase
MCCS_RS09360	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
MCCS_RS09370	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
MCCS_RS09375	COG1169	isochorismate synthase
MCCS_RS09380	COG1575	Belongs to the MenA family. Type 1 subfamily
MCCS_RS09460	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
MCCS_RS09470	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
MCCS_RS09485	COG1131	(ABC) transporter
MCCS_RS09490	COG0537	adenosine 5'-monophosphoramidase activity
MCCS_RS09500	COG1846	Transcriptional regulator
MCCS_RS09510	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
MCCS_RS09515	COG3481	metal-dependent phosphohydrolase, HD sub domain
MCCS_RS09530	COG0635	Involved in the biosynthesis of porphyrin-containing compound
MCCS_RS09535	COG3679	Belongs to the UPF0342 family
MCCS_RS09540	COG4399	Belongs to the UPF0754 family
MCCS_RS09550	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
MCCS_RS09560	COG2197	response regulator
MCCS_RS09565	COG4585	Histidine kinase
MCCS_RS09565	COG2203	Gaf domain
MCCS_RS09570	COG3153	acetyltransferase
MCCS_RS09570	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MCCS_RS09575	COG0564	pseudouridine synthase activity
MCCS_RS09580	COG0778	Nitroreductase
MCCS_RS09585	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
MCCS_RS09590	COG0248	Ppx GppA phosphatase
MCCS_RS09595	COG0114	fumarate hydratase activity
MCCS_RS09605	COG0363	glucosamine-6-phosphate deaminase activity
MCCS_RS09610	COG0778	Nitroreductase
MCCS_RS09615	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
MCCS_RS09620	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
MCCS_RS09625	COG1126	abc transporter atp-binding protein
MCCS_RS09630	COG0765	amino acid transport
MCCS_RS09635	COG0436	Aminotransferase
MCCS_RS09820	COG0735	belongs to the Fur family
MCCS_RS09825	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MCCS_RS09830	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
MCCS_RS09835	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
MCCS_RS09840	COG4129	membrane
MCCS_RS09845	COG2094	Belongs to the DNA glycosylase MPG family
MCCS_RS09850	COG0069	glutamate synthase activity
MCCS_RS09870	COG1988	membrane-bound metal-dependent
MCCS_RS09880	COG1134	teichoic acid transport
MCCS_RS09880	COG1388	LysM domain
MCCS_RS09890	COG2137	regulation of response to DNA damage stimulus
MCCS_RS09895	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MCCS_RS09900	COG0693	protein deglycase activity
MCCS_RS09905	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MCCS_RS09915	COG0535	radical SAM domain protein
MCCS_RS09920	COG1607	acyl-coa hydrolase
MCCS_RS09925	COG2309	aminopeptidase activity
MCCS_RS09930	COG4840	Belongs to the UPF0435 family
MCCS_RS09940	COG1295	ribonuclease BN
MCCS_RS09945	COG0288	reversible hydration of carbon dioxide
MCCS_RS09950	COG2197	response regulator
MCCS_RS09970	COG0024	Methionine aminopeptidase
MCCS_RS09975	COG4129	membrane
MCCS_RS09980	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
MCCS_RS10000	COG1528	Iron-storage protein
MCCS_RS10020	COG3949	Membrane
MCCS_RS10035	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MCCS_RS10055	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MCCS_RS10060	COG0737	Belongs to the 5'-nucleotidase family
MCCS_RS10065	COG1028	Short-chain dehydrogenase reductase Sdr
MCCS_RS10070	COG1597	lipid kinase activity
MCCS_RS10075	COG0433	COG0433 Predicted ATPase
MCCS_RS10090	COG4464	protein tyrosine phosphatase activity
MCCS_RS10095	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MCCS_RS10100	COG0154	amidase activity
MCCS_RS10105	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MCCS_RS10110	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MCCS_RS10115	COG4851	CamS sex pheromone cAM373 precursor
MCCS_RS10120	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
MCCS_RS10125	COG0210	DNA helicase
MCCS_RS10130	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
MCCS_RS10135	COG1876	peptidase activity
MCCS_RS10140	COG1876	peptidase activity
MCCS_RS10145	COG4496	protein, YerC YecD
MCCS_RS10155	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
MCCS_RS10165	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
MCCS_RS10175	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
MCCS_RS10180	COG0477	Major facilitator Superfamily
MCCS_RS10190	COG5434	Belongs to the glycosyl hydrolase 28 family
MCCS_RS10195	COG1335	isochorismatase
MCCS_RS10200	COG1227	inorganic diphosphatase activity
MCCS_RS10210	COG0673	inositol 2-dehydrogenase activity
MCCS_RS10215	COG1012	belongs to the aldehyde dehydrogenase family
MCCS_RS10220	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MCCS_RS10225	COG2706	6-phosphogluconolactonase activity
MCCS_RS10230	COG1982	Orn Lys Arg decarboxylase major
MCCS_RS10235	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
MCCS_RS10240	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
MCCS_RS10245	COG0010	Belongs to the arginase family
MCCS_RS10300	COG1902	pentaerythritol trinitrate reductase activity
MCCS_RS10350	COG0488	(ABC) transporter
MCCS_RS10375	COG0471	metal ion transport
MCCS_RS10385	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
MCCS_RS10405	COG3655	Transcriptional regulator
MCCS_RS10425	COG1132	(ABC) transporter
MCCS_RS10440	COG2258	MOSC domain
MCCS_RS10455	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
MCCS_RS10465	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
MCCS_RS10475	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
MCCS_RS10485	COG0402	S-adenosylhomocysteine deaminase activity
MCCS_RS10490	COG1373	ATPase (AAA superfamily
MCCS_RS10520	COG0745	RESPONSE REGULATOR receiver
MCCS_RS10525	COG0642	Histidine kinase
MCCS_RS10540	COG2205	protein histidine kinase activity
MCCS_RS10560	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
MCCS_RS10640	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MCCS_RS10645	COG1279	arginine transmembrane transporter activity
MCCS_RS10655	COG0583	DNA-binding transcription factor activity
MCCS_RS10670	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MCCS_RS10675	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MCCS_RS10680	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MCCS_RS10690	COG2801	Transposase and inactivated derivatives
MCCS_RS10695	COG0459	protein refolding
MCCS_RS10700	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
MCCS_RS10725	COG2514	catechol 2,3-dioxygenase activity
MCCS_RS10735	COG1737	Transcriptional regulator
MCCS_RS10740	COG1621	beta-fructofuranosidase activity
MCCS_RS10745	COG0805	protein transport
MCCS_RS10750	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MCCS_RS10755	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
MCCS_RS10760	COG0488	(ABC) transporter
MCCS_RS10765	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
MCCS_RS10770	COG0456	acetyltransferase
MCCS_RS10775	COG1214	PFAM Peptidase M22, glycoprotease
MCCS_RS10780	COG0802	atpase or kinase
MCCS_RS10815	COG3091	SprT-like family
MCCS_RS10820	COG2183	response to ionizing radiation
MCCS_RS10825	COG1191	sigma factor activity
MCCS_RS10840	COG2208	phosphoserine phosphatase activity
MCCS_RS10850	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
MCCS_RS10855	COG0736	holo-[acyl-carrier-protein] synthase activity
MCCS_RS10860	COG3402	PFAM membrane-flanked domain
MCCS_RS10865	COG3428	Bacterial PH domain
MCCS_RS10875	COG0513	Belongs to the DEAD box helicase family
MCCS_RS10880	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
MCCS_RS10885	COG1181	Belongs to the D-alanine--D-alanine ligase family
MCCS_RS10890	COG0772	Belongs to the SEDS family
MCCS_RS10895	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MCCS_RS10900	COG1418	mRNA catabolic process
MCCS_RS10905	COG0706	membrane insertase activity
MCCS_RS10910	COG0352	thiamine-phosphate diphosphorylase activity
MCCS_RS10915	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
MCCS_RS10925	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
MCCS_RS10940	COG0629	single-stranded DNA binding
MCCS_RS10950	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
MCCS_RS10960	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
MCCS_RS10970	COG0355	proton-transporting ATP synthase activity, rotational mechanism
MCCS_RS10975	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
MCCS_RS10980	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
MCCS_RS10985	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
MCCS_RS10990	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
MCCS_RS10995	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
MCCS_RS11005	COG0356	it plays a direct role in the translocation of protons across the membrane
MCCS_RS11015	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
MCCS_RS11020	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
MCCS_RS11025	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
MCCS_RS11035	COG0698	ribose 5-phosphate isomerase
MCCS_RS11040	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MCCS_RS11045	COG0009	L-threonylcarbamoyladenylate synthase
MCCS_RS11050	COG2890	protein-(glutamine-N5) methyltransferase activity
MCCS_RS11055	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
MCCS_RS11060	COG1435	thymidine kinase activity
MCCS_RS11065	COG0254	rRNA binding
MCCS_RS11070	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
MCCS_RS11075	COG1494	fructose-1,6-bisphosphatase
MCCS_RS11085	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
MCCS_RS11095	COG2204	response regulator
MCCS_RS11105	COG0504	CTP synthase activity
MCCS_RS11110	COG3343	RNA polymerase activity
MCCS_RS11120	COG5146	pantothenate kinase activity
MCCS_RS11140	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
MCCS_RS11145	COG0626	cystathionine gamma-synthase activity
MCCS_RS11150	COG1854	S-ribosylhomocysteine lyase activity
MCCS_RS11165	COG3266	domain, Protein
MCCS_RS11165	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
MCCS_RS11165	COG4932	domain protein
MCCS_RS11170	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
MCCS_RS11175	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
MCCS_RS11180	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
MCCS_RS11185	COG2390	Transcriptional regulator
MCCS_RS11190	COG0783	Belongs to the Dps family
MCCS_RS11200	COG2814	Major facilitator Superfamily
MCCS_RS11210	COG1316	TRANSCRIPTIONal
MCCS_RS11225	COG1757	Na H antiporter
MCCS_RS11240	COG3266	domain, Protein
MCCS_RS11240	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
MCCS_RS11240	COG4932	domain protein
MCCS_RS11250	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
MCCS_RS11250	COG4932	domain protein
MCCS_RS11250	COG3266	domain, Protein
MCCS_RS11255	COG3266	domain, Protein
MCCS_RS11255	COG4932	domain protein
MCCS_RS11255	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
MCCS_RS11300	COG3266	domain, Protein
MCCS_RS11300	COG4932	domain protein
MCCS_RS11300	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
MCCS_RS11305	COG3266	domain, Protein
MCCS_RS11305	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
MCCS_RS11305	COG4932	domain protein
MCCS_RS11315	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
MCCS_RS11315	COG4932	domain protein
MCCS_RS11315	COG3266	domain, Protein
MCCS_RS11330	COG3266	domain, Protein
MCCS_RS11330	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
MCCS_RS11330	COG4932	domain protein
MCCS_RS11355	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
MCCS_RS11365	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
MCCS_RS11365	COG3266	domain, Protein
MCCS_RS11365	COG4932	domain protein
MCCS_RS11395	COG5295	Hep Hag repeat protein
MCCS_RS11395	COG4932	domain protein
MCCS_RS11405	COG0438	transferase activity, transferring glycosyl groups
MCCS_RS11425	COG1073	alpha beta
MCCS_RS11435	COG0201	protein transport
MCCS_RS11485	COG2855	membrane
MCCS_RS11490	COG1525	nuclease
MCCS_RS11505	COG1272	protein, Hemolysin III
MCCS_RS11525	COG2226	methyltransferase
MCCS_RS11530	COG2267	carboxylic ester hydrolase activity
MCCS_RS11550	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MCCS_RS11555	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MCCS_RS11560	COG0018	arginyl-trna synthetase
MCCS_RS11575	COG1078	dGTPase activity
MCCS_RS11590	COG1850	ribulose-bisphosphate carboxylase activity
MCCS_RS11600	COG0235	Class ii aldolase
MCCS_RS11605	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
MCCS_RS11625	COG4844	belongs to the
MCCS_RS11630	COG0095	Lipoate-protein ligase
MCCS_RS11640	COG3253	May function as heme-dependent peroxidase
MCCS_RS11645	COG4607	ABC-type enterochelin transport system periplasmic component
MCCS_RS11650	COG4604	ABC transporter, ATP-binding protein
MCCS_RS11655	COG4605	iron ion homeostasis
MCCS_RS11660	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MCCS_RS11665	COG0531	amino acid
MCCS_RS11670	COG2363	Small membrane protein
MCCS_RS11680	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
MCCS_RS11695	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
MCCS_RS11700	COG1469	GTP cyclohydrolase I activity
MCCS_RS11705	COG0110	maltose O-acetyltransferase activity
MCCS_RS11710	COG0561	phosphatase activity
MCCS_RS11720	COG1428	Deoxynucleoside kinase
MCCS_RS11725	COG1428	Deoxynucleoside kinase
MCCS_RS11730	COG0546	phosphoglycolate phosphatase activity
MCCS_RS11755	COG1473	amidohydrolase
MCCS_RS11760	COG1473	amidohydrolase
MCCS_RS11765	COG1473	amidohydrolase
MCCS_RS11770	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
MCCS_RS11775	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
MCCS_RS11780	COG0049	tRNA binding
MCCS_RS11785	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
MCCS_RS11810	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
MCCS_RS11815	COG0085	RNA polymerase activity
MCCS_RS11820	COG2813	Specifically methylates the guanine in position
MCCS_RS11825	COG0222	ribosome binding
MCCS_RS11830	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
MCCS_RS11835	COG0081	regulation of translation
MCCS_RS11840	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
MCCS_RS11855	COG1595	DNA-templated transcription, initiation
MCCS_RS11865	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MCCS_RS11870	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
MCCS_RS11875	COG0215	cysteine-tRNA ligase activity
MCCS_RS11885	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MCCS_RS11900	COG4956	integral membrane protein (PIN domain superfamily)
MCCS_RS11905	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
MCCS_RS11910	COG0542	response to heat
MCCS_RS11915	COG3869	Catalyzes the specific phosphorylation of arginine residues in
MCCS_RS11920	COG3880	PFAM UvrB UvrC protein
MCCS_RS11925	COG4463	regulation of RNA biosynthetic process
MCCS_RS11930	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
MCCS_RS11935	COG0778	Nitroreductase
MCCS_RS11940	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
MCCS_RS11945	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
MCCS_RS11950	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MCCS_RS12020	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
MCCS_RS12025	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
MCCS_RS12030	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
MCCS_RS12030	COG0302	gtp cyclohydrolase
MCCS_RS12035	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
MCCS_RS12045	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
MCCS_RS12050	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
MCCS_RS12055	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MCCS_RS12070	COG1098	S1 RNA binding domain
MCCS_RS12080	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
MCCS_RS12085	COG3956	TIGRFAM MazG family protein
MCCS_RS12090	COG2244	polysaccharide biosynthetic process
MCCS_RS12095	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
MCCS_RS12100	COG0193	aminoacyl-tRNA hydrolase activity
MCCS_RS12105	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
MCCS_RS12110	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
MCCS_RS12115	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
MCCS_RS12120	COG2088	sporulation resulting in formation of a cellular spore
MCCS_RS12125	COG0251	oxidation-reduction process
MCCS_RS12130	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
MCCS_RS12135	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
MCCS_RS12140	COG4466	Protein conserved in bacteria
MCCS_RS12145	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
MCCS_RS12150	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
MCCS_RS12160	COG0084	hydrolase, TatD family'
MCCS_RS12170	COG2002	toxin-antitoxin pair type II binding
MCCS_RS12175	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
MCCS_RS12180	COG2827	Endonuclease containing a URI domain
MCCS_RS12185	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
MCCS_RS12190	COG4467	Involved in initiation control of chromosome replication
MCCS_RS12195	COG1774	PSP1 C-terminal conserved region
MCCS_RS12200	COG0470	DNA polymerase III
MCCS_RS12205	COG3870	Protein conserved in bacteria
MCCS_RS12210	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
MCCS_RS12215	COG1982	Orn Lys Arg decarboxylase major
MCCS_RS12235	COG4667	esterase of the alpha-beta hydrolase superfamily
MCCS_RS12245	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
MCCS_RS12260	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
MCCS_RS12265	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
MCCS_RS12270	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
MCCS_RS12280	COG2188	Transcriptional regulator
MCCS_RS12285	COG0366	Alpha amylase catalytic
MCCS_RS12290	COG1263	PTS System
MCCS_RS12290	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MCCS_RS12365	COG0582	viral genome integration into host DNA
MCCS_RS12375	COG0518	GMP synthase (glutamine-hydrolyzing) activity
MCCS_RS12375	COG0519	Catalyzes the synthesis of GMP from XMP
MCCS_RS12380	COG0516	GMP reductase activity
MCCS_RS12380	COG0517	IMP dehydrogenase activity
MCCS_RS12385	COG2233	PERMEase
MCCS_RS12390	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
MCCS_RS12410	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
MCCS_RS12430	COG0012	GTP binding
MCCS_RS12435	COG4481	Protein conserved in bacteria
MCCS_RS12440	COG0668	transmembrane transport
MCCS_RS12445	COG1475	DNA binding
MCCS_RS12450	COG1192	Involved in chromosome partitioning
MCCS_RS12455	COG1475	DNA binding
MCCS_RS12460	COG0357	Ribosomal RNA small subunit methyltransferase G
MCCS_RS12465	COG0445	tRNA wobble uridine modification
MCCS_RS12470	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
MCCS_RS12475	COG1847	R3H domain protein
MCCS_RS12480	COG0594	ribonuclease P activity