locus-tag	class	description
D9L16_mgp06	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D9L16_mgp07	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D9L16_mgp08	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
D9L16_mgp09	COG0713	ATP synthesis coupled electron transport
D9L16_mgp10	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
D9L16_mgp11	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
D9L16_mgp12	COG0839	Belongs to the complex I subunit 6 family
D9L16_mgp13	COG1845	cytochrome c oxidase, subunit III
D9L16_mgp14	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D9L16_mgp15	COG1007	ATP synthesis coupled electron transport
MRET_0017	COG0484	heat shock protein binding
MRET_0018	COG0205	6-phosphofructokinase activity
MRET_0024	COG0484	heat shock protein binding
MRET_0025	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MRET_0027	COG1643	Atp-dependent helicase
MRET_0031	COG1643	Atp-dependent helicase
MRET_0037	COG0724	RNA recognition motif
MRET_0057	COG0230	Belongs to the bacterial ribosomal protein bL34 family
MRET_0068	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
MRET_0069	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
MRET_0077	COG0318	PFAM AMP-dependent synthetase and ligase
MRET_0090	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
MRET_0094	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MRET_0095	COG1132	(ABC) transporter
MRET_0099	COG0105	UTP biosynthetic process
MRET_0110	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
MRET_0111	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
MRET_0123	COG0626	cystathionine gamma-synthase activity
MRET_0135	COG2267	carboxylic ester hydrolase activity
MRET_0136	COG2313	pseudouridylate synthase activity
MRET_0143	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MRET_0145	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
MRET_0151	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MRET_0151	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MRET_0156	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
MRET_0161	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
MRET_0180	COG1482	cell wall glycoprotein biosynthetic process
MRET_0188	COG0006	proline dipeptidase activity
MRET_0195	COG2255	four-way junction helicase activity
MRET_0196	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
MRET_0208	COG0488	(ABC) transporter
MRET_0211	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
MRET_0224	COG1612	heme a metabolic process
MRET_0227	COG0513	Belongs to the DEAD box helicase family
MRET_0241	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
MRET_0260	COG0513	Belongs to the DEAD box helicase family
MRET_0265	COG0513	Belongs to the DEAD box helicase family
MRET_0267	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
MRET_0273	COG2814	Major facilitator Superfamily
MRET_0289	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
MRET_0291	COG0191	fructose-bisphosphate aldolase activity
MRET_0295	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
MRET_0296	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
MRET_0297	COG0022	dehydrogenase e1 component
MRET_0297	COG0508	dehydrogenase complex catalyzes the overall conversion of
MRET_0302	COG0724	RNA recognition motif
MRET_0303	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
MRET_0308	COG0215	cysteine-tRNA ligase activity
MRET_0314	COG1648	precorrin-2 dehydrogenase activity
MRET_0314	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
MRET_0337	COG0484	heat shock protein binding
MRET_0346	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
MRET_0353	COG0285	dihydrofolate synthase activity
MRET_0357	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
MRET_0361	COG0724	RNA recognition motif
MRET_0367	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
MRET_0382	COG1022	Amp-dependent synthetase and ligase
MRET_0387	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
MRET_0392	COG1234	tRNA 3'-trailer cleavage
MRET_0409	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MRET_0413	COG0515	serine threonine protein kinase
MRET_0413	COG2815	serine threonine protein kinase
MRET_0428	COG0133	tryptophan synthase activity
MRET_0431	COG1230	cation diffusion facilitator family transporter
MRET_0438	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
MRET_0453	COG2154	pterin-4-alpha-carbinolamine dehydratase
MRET_0468	COG1643	Atp-dependent helicase
MRET_0476	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
MRET_0477	COG0432	Pfam Uncharacterised protein family UPF0047
MRET_0479	COG0515	serine threonine protein kinase
MRET_0479	COG2815	serine threonine protein kinase
MRET_0483	COG0513	Belongs to the DEAD box helicase family
MRET_0484	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MRET_0487	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MRET_0492	COG0659	secondary active sulfate transmembrane transporter activity
MRET_0499	COG0481	GTPase activity
MRET_0502	COG0156	8-amino-7-oxononanoate synthase activity
MRET_0522	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
MRET_0523	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
MRET_0534	COG1222	aaa ATPase
MRET_0544	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
MRET_0556	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MRET_0563	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
MRET_0564	COG0823	Involved in the tonB-independent uptake of proteins
MRET_0564	COG1506	peptidase
MRET_0566	COG0436	Aminotransferase
MRET_0568	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
MRET_0569	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
MRET_0574	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
MRET_0576	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
MRET_0579	COG0459	protein refolding
MRET_0589	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
MRET_0606	COG3118	belongs to the thioredoxin family
MRET_0610	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MRET_0611	COG0039	L-malate dehydrogenase activity
MRET_0613	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
MRET_0620	COG0165	Argininosuccinate lyase
MRET_0626	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
MRET_0629	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
MRET_0648	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
MRET_0655	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
MRET_0660	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
MRET_0671	COG0495	leucyl-tRNA aminoacylation
MRET_0675	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
MRET_0676	COG1160	GTP binding
MRET_0677	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
MRET_0678	COG1132	(ABC) transporter
MRET_0679	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MRET_0680	COG0513	Belongs to the DEAD box helicase family
MRET_0690	COG0515	serine threonine protein kinase
MRET_0690	COG2815	serine threonine protein kinase
MRET_0695	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
MRET_0698	COG0515	serine threonine protein kinase
MRET_0699	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MRET_0704	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MRET_0709	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
MRET_0714	COG0529	Catalyzes the synthesis of activated sulfate
MRET_0714	COG2046	Belongs to the sulfate adenylyltransferase family
MRET_0721	COG0859	PFAM glycosyl transferase family 9
MRET_0721	COG0457	Tetratricopeptide repeat
MRET_0733	COG4178	(ABC) transporter
MRET_0743	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MRET_0755	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
MRET_0758	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MRET_0758	COG0047	phosphoribosylformylglycinamidine synthase activity
MRET_0775	COG0328	RNA-DNA hybrid ribonuclease activity
MRET_0776	COG2124	cytochrome p450
MRET_0776	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
MRET_0788	COG2815	serine threonine protein kinase
MRET_0788	COG0515	serine threonine protein kinase
MRET_0800	COG0505	Belongs to the CarA family
MRET_0803	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
MRET_0811	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
MRET_0821	COG0484	heat shock protein binding
MRET_0822	COG0670	Belongs to the BI1 family
MRET_0824	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
MRET_0826	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
MRET_0830	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
MRET_0832	COG1028	Short-chain dehydrogenase reductase Sdr
MRET_0843	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
MRET_0846	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
MRET_0849	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
MRET_0851	COG0417	DNA replication proofreading
MRET_0856	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MRET_0859	COG0211	Belongs to the bacterial ribosomal protein bL27 family
MRET_0870	COG0200	Binds to the 23S rRNA
MRET_0871	COG0513	Belongs to the DEAD box helicase family
MRET_0872	COG0439	Biotin carboxylase
MRET_0898	COG0557	exoribonuclease II activity
MRET_0900	COG1643	Atp-dependent helicase
MRET_0904	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
MRET_0908	COG1448	Aminotransferase
MRET_0910	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
MRET_0913	COG0131	Imidazoleglycerol-phosphate dehydratase
MRET_0917	COG0083	homoserine kinase activity
MRET_0919	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
MRET_0926	COG0183	Belongs to the thiolase family
MRET_0933	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
MRET_0938	COG0484	heat shock protein binding
MRET_0945	COG0534	Mate efflux family protein
MRET_0947	COG0484	heat shock protein binding
MRET_0956	COG1643	Atp-dependent helicase
MRET_0958	COG0714	Associated with various cellular activities
MRET_0960	COG0513	Belongs to the DEAD box helicase family
MRET_0966	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
MRET_0979	COG0515	serine threonine protein kinase
MRET_0995	COG0515	serine threonine protein kinase
MRET_0995	COG2815	serine threonine protein kinase
MRET_1003	COG0473	3-isopropylmalate dehydrogenase activity
MRET_1010	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
MRET_1010	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
MRET_1011	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
MRET_1025	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
MRET_1049	COG0418	dihydroorotase activity
MRET_1062	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
MRET_1068	COG0123	including yeast histone deacetylase and acetoin utilization protein
MRET_1076	COG0009	L-threonylcarbamoyladenylate synthase
MRET_1091	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MRET_1099	COG2814	Major facilitator Superfamily
MRET_1102	COG4589	Belongs to the CDS family
MRET_1103	COG0515	serine threonine protein kinase
MRET_1103	COG2815	serine threonine protein kinase
MRET_1114	COG0443	Heat shock 70 kDa protein
MRET_1131	COG4221	oxidoreductase activity
MRET_1158	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
MRET_1176	COG0049	tRNA binding
MRET_1189	COG1022	Amp-dependent synthetase and ligase
MRET_1189	COG3320	Male sterility
MRET_1192	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
MRET_1196	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
MRET_1219	COG0515	serine threonine protein kinase
MRET_1227	COG0417	DNA replication proofreading
MRET_1234	COG2895	sulfate adenylyltransferase (ATP) activity
MRET_1241	COG0105	UTP biosynthetic process
MRET_1242	COG0557	exoribonuclease II activity
MRET_1243	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MRET_1248	COG2271	Major facilitator Superfamily
MRET_1251	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
MRET_1253	COG0515	serine threonine protein kinase
MRET_1253	COG2815	serine threonine protein kinase
MRET_1256	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
MRET_1261	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
MRET_1264	COG0443	Heat shock 70 kDa protein
MRET_1270	COG0647	UMP catabolic process
MRET_1273	COG2814	Major facilitator Superfamily
MRET_1276	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MRET_1279	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
MRET_1309	COG0123	including yeast histone deacetylase and acetoin utilization protein
MRET_1321	COG0017	Asparaginyl-tRNA synthetase
MRET_1329	COG0488	(ABC) transporter
MRET_1335	COG2815	serine threonine protein kinase
MRET_1335	COG0515	serine threonine protein kinase
MRET_1340	COG0515	serine threonine protein kinase
MRET_1340	COG2815	serine threonine protein kinase
MRET_1347	COG0508	dehydrogenase complex catalyzes the overall conversion of
MRET_1357	COG0227	Belongs to the bacterial ribosomal protein bL28 family
MRET_1359	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
MRET_1386	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
MRET_1395	COG0443	Heat shock 70 kDa protein
MRET_1404	COG2132	Multicopper oxidase
MRET_1405	COG3511	phospholipase C
MRET_1409	COG1584	GPR1 FUN34 yaaH family protein
MRET_1428	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
MRET_1431	COG0504	CTP synthase activity
MRET_1449	COG0017	Asparaginyl-tRNA synthetase
MRET_1455	COG0318	PFAM AMP-dependent synthetase and ligase
MRET_1467	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
MRET_1469	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
MRET_1470	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
MRET_1476	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MRET_1479	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
MRET_1482	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MRET_1484	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MRET_1487	COG0512	Glutamine amidotransferase of anthranilate synthase
MRET_1489	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MRET_1497	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
MRET_1505	COG3266	domain, Protein
MRET_1505	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
MRET_1514	COG0228	four-way junction DNA binding
MRET_1522	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
MRET_1527	COG0626	cystathionine gamma-synthase activity
MRET_1532	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
MRET_1538	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
MRET_1542	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
MRET_1549	COG0070	glutamate synthase
MRET_1549	COG0069	glutamate synthase activity
MRET_1549	COG0067	glutamate synthase
MRET_1551	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
MRET_1574	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
MRET_1580	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
MRET_1581	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MRET_1585	COG0515	serine threonine protein kinase
MRET_1586	COG0003	Pfam Anion-transporting ATPase
MRET_1590	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
MRET_1592	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
MRET_1595	COG2814	Major facilitator Superfamily
MRET_1598	COG2814	Major facilitator Superfamily
MRET_1602	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
MRET_1615	COG1132	(ABC) transporter
MRET_1621	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
MRET_1631	COG0513	Belongs to the DEAD box helicase family
MRET_1645	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MRET_1655	COG0515	serine threonine protein kinase
MRET_1655	COG2815	serine threonine protein kinase
MRET_1656	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
MRET_1675	COG0706	membrane insertase activity
MRET_1689	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
MRET_1698	COG1185	polyribonucleotide nucleotidyltransferase activity
MRET_1706	COG0129	dihydroxy-acid dehydratase activity
MRET_1707	COG0688	phosphatidylethanolamine metabolic process
MRET_1731	COG0542	response to heat
MRET_1739	COG0484	heat shock protein binding
MRET_1763	COG0514	ATP-dependent DNA helicase (RecQ)
MRET_1765	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
MRET_1766	COG0442	prolyl-tRNA aminoacylation
MRET_1802	COG1643	Atp-dependent helicase
MRET_1809	COG0281	malic enzyme
MRET_1811	COG1111	helicase
MRET_1811	COG1205	dead DEAH box helicase
MRET_1816	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
MRET_1823	COG0285	dihydrofolate synthase activity
MRET_1839	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
MRET_1840	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
MRET_1842	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
MRET_1843	COG0484	heat shock protein binding
MRET_1846	COG0483	inositol monophosphate 1-phosphatase activity
MRET_1855	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
MRET_1861	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
MRET_1865	COG0220	tRNA (guanine-N7-)-methyltransferase activity
MRET_1869	COG0515	serine threonine protein kinase
MRET_1869	COG2815	serine threonine protein kinase
MRET_1879	COG0604	alcohol dehydrogenase
MRET_1882	COG0557	exoribonuclease II activity
MRET_1883	COG0513	Belongs to the DEAD box helicase family
MRET_1885	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
MRET_1890	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
MRET_1899	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
MRET_1903	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MRET_1903	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MRET_1915	COG0406	alpha-ribazole phosphatase activity
MRET_1955	COG0572	uridine kinase
MRET_1956	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
MRET_1957	COG1122	ATPase activity
MRET_1968	COG0137	argininosuccinate synthase activity
MRET_1970	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
MRET_1973	COG1028	Short-chain dehydrogenase reductase Sdr
MRET_1974	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
MRET_1986	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
MRET_1995	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
MRET_2000	COG0288	reversible hydration of carbon dioxide
MRET_2005	COG1505	serine-type exopeptidase activity
MRET_2006	COG1160	GTP binding
MRET_2020	COG1073	alpha beta
MRET_2037	COG3118	belongs to the thioredoxin family
MRET_2042	COG0114	fumarate hydratase activity
MRET_2050	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
MRET_2051	COG2814	Major facilitator Superfamily
MRET_2054	COG0081	regulation of translation
MRET_2058	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
MRET_2062	COG5265	(ABC) transporter
MRET_2073	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
MRET_2083	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
MRET_2087	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
MRET_2088	COG1012	belongs to the aldehyde dehydrogenase family
MRET_2096	COG0489	protein tyrosine kinase activity
MRET_2106	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
MRET_2108	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
MRET_2116	COG2814	Major facilitator Superfamily
MRET_2118	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
MRET_2124	COG1960	acyl-CoA dehydrogenase activity
MRET_2126	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
MRET_2128	COG0484	heat shock protein binding
MRET_2135	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
MRET_2144	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
MRET_2150	COG0515	serine threonine protein kinase
MRET_2174	COG0513	Belongs to the DEAD box helicase family
MRET_2176	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
MRET_2180	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
MRET_2186	COG3590	peptidase
MRET_2187	COG3590	peptidase
MRET_2209	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
MRET_2212	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MRET_2214	COG1132	(ABC) transporter
MRET_2215	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
MRET_2230	COG3961	Belongs to the TPP enzyme family
MRET_2243	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MRET_2243	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MRET_2253	COG2271	Major facilitator Superfamily
MRET_2256	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
MRET_2258	COG2815	serine threonine protein kinase
MRET_2258	COG0515	serine threonine protein kinase
MRET_2267	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MRET_2273	COG0018	arginyl-trna synthetase
MRET_2274	COG0218	Necessary for normal cell division and for the maintenance of normal septation
MRET_2277	COG0405	Gamma-glutamyltransferase
MRET_2282	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
MRET_2289	COG0494	nUDIX hydrolase
MRET_2294	COG1196	nuclear chromosome segregation
MRET_2304	COG0038	chloride channel
MRET_2309	COG4178	(ABC) transporter
MRET_2319	COG0515	serine threonine protein kinase
MRET_2329	COG0842	Transport permease protein
MRET_2329	COG1131	(ABC) transporter
MRET_2329	COG1716	ATPase activity
MRET_2330	COG1716	ATPase activity
MRET_2330	COG1131	(ABC) transporter
MRET_2330	COG0842	Transport permease protein
MRET_2344	COG0489	protein tyrosine kinase activity
MRET_2352	COG0518	GMP synthase (glutamine-hydrolyzing) activity
MRET_2352	COG0519	Catalyzes the synthesis of GMP from XMP
MRET_2358	COG1648	precorrin-2 dehydrogenase activity
MRET_2358	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
MRET_2361	COG2252	PERMEase
MRET_2365	COG3511	phospholipase C
MRET_2366	COG0667	Aldo Keto reductase
MRET_2374	COG0367	asparagine synthase
MRET_2377	COG1028	Short-chain dehydrogenase reductase Sdr
MRET_2379	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MRET_2387	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
MRET_2390	COG0596	Alpha beta hydrolase
MRET_2394	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
MRET_2395	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
MRET_2396	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
MRET_2401	COG0469	pyruvate kinase activity
MRET_2403	COG2226	methyltransferase
MRET_2407	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
MRET_2417	COG0443	Heat shock 70 kDa protein
MRET_2418	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
MRET_2422	COG0459	protein refolding
MRET_2424	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
MRET_2430	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
MRET_2434	COG1196	nuclear chromosome segregation
MRET_2447	COG0515	serine threonine protein kinase
MRET_2447	COG2815	serine threonine protein kinase
MRET_2449	COG0017	Asparaginyl-tRNA synthetase
MRET_2455	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
MRET_2457	COG0564	pseudouridine synthase activity
MRET_2463	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MRET_2471	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
MRET_2473	COG2119	membrane
MRET_2477	COG0052	Belongs to the universal ribosomal protein uS2 family
MRET_2479	COG1132	(ABC) transporter
MRET_2492	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
MRET_2493	COG1119	ATPase activity
MRET_2496	COG2264	protein methyltransferase activity
MRET_2501	COG0445	tRNA wobble uridine modification
MRET_2506	COG0142	geranyltranstransferase activity
MRET_2507	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MRET_2511	COG2224	Isocitrate lyase
MRET_2516	COG0149	triose-phosphate isomerase activity
MRET_2519	COG0138	bifunctional purine biosynthesis protein purh
MRET_2521	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
MRET_2522	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
MRET_2524	COG1064	alcohol dehydrogenase
MRET_2530	COG0440	acetolactate synthase activity
MRET_2539	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
MRET_2544	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
MRET_2549	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MRET_2551	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
MRET_2558	COG0450	alkyl hydroperoxide reductase
MRET_2559	COG1028	Short-chain dehydrogenase reductase Sdr
MRET_2562	COG1253	flavin adenine dinucleotide binding
MRET_2563	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
MRET_2564	COG0037	tRNA processing
MRET_2568	COG0473	3-isopropylmalate dehydrogenase activity
MRET_2573	COG1362	aminopeptidase activity
MRET_2584	COG0085	RNA polymerase activity
MRET_2587	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MRET_2587	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MRET_2589	COG0404	The glycine cleavage system catalyzes the degradation of glycine
MRET_2590	COG1132	(ABC) transporter
MRET_2592	COG0088	Forms part of the polypeptide exit tunnel
MRET_2600	COG0308	aminopeptidase N
MRET_2627	COG0531	amino acid
MRET_2628	COG1643	Atp-dependent helicase
MRET_2638	COG1448	Aminotransferase
MRET_2643	COG1185	polyribonucleotide nucleotidyltransferase activity
MRET_2655	COG0101	tRNA pseudouridine synthase activity
MRET_2662	COG3940	Belongs to the glycosyl hydrolase 43 family
MRET_2669	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
MRET_2687	COG2814	Major facilitator Superfamily
MRET_2689	COG0513	Belongs to the DEAD box helicase family
MRET_2693	COG0442	prolyl-tRNA aminoacylation
MRET_2694	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
MRET_2695	COG0484	heat shock protein binding
MRET_2703	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
MRET_2703	COG0515	serine threonine protein kinase
MRET_2713	COG0833	amino acid
MRET_2727	COG0076	glutamate decarboxylase activity
MRET_2729	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
MRET_2730	COG0481	GTPase activity
MRET_2758	COG0459	protein refolding
MRET_2760	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
MRET_2764	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
MRET_2765	COG0124	histidyl-tRNA synthetase
MRET_2767	COG0251	oxidation-reduction process
MRET_2777	COG0804	urea catabolic process
MRET_2800	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
MRET_2800	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
MRET_2801	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
MRET_2806	COG2897	thiosulfate sulfurtransferase activity
MRET_2810	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
MRET_2818	COG2267	carboxylic ester hydrolase activity
MRET_2831	COG0072	phenylalanine-tRNA ligase activity
MRET_2857	COG2815	serine threonine protein kinase
MRET_2857	COG0515	serine threonine protein kinase
MRET_2871	COG0477	Major facilitator Superfamily
MRET_2880	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
MRET_2891	COG0833	amino acid
MRET_2892	COG1113	amino acid transport
MRET_2893	COG0833	amino acid
MRET_2894	COG0833	amino acid
MRET_2897	COG0408	coproporphyrinogen oxidase activity
MRET_2899	COG0515	serine threonine protein kinase
MRET_2902	COG0142	geranyltranstransferase activity
MRET_2912	COG1760	l-serine dehydratase
MRET_2920	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
MRET_2941	COG1643	Atp-dependent helicase
MRET_2946	COG0515	serine threonine protein kinase
MRET_2946	COG2815	serine threonine protein kinase
MRET_2964	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
MRET_2968	COG0424	maF-like protein
MRET_2970	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MRET_2975	COG1902	pentaerythritol trinitrate reductase activity
MRET_2988	COG0604	alcohol dehydrogenase
MRET_2988	COG1028	Short-chain dehydrogenase reductase Sdr
MRET_2988	COG3321	synthase
MRET_2989	COG0033	Phosphoglucomutase
MRET_2993	COG2086	electron transfer activity
MRET_2996	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
MRET_2998	COG1132	(ABC) transporter
MRET_2999	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
MRET_3000	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
MRET_3007	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
MRET_3023	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MRET_3032	COG0181	hydroxymethylbilane synthase activity
MRET_3036	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
MRET_3044	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
MRET_3063	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MRET_3073	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
MRET_3075	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
MRET_3090	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MRET_3091	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
MRET_3100	COG0829	nickel cation binding
MRET_3119	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
MRET_3129	COG1914	H( )-stimulated, divalent metal cation uptake system
MRET_3131	COG3321	synthase
MRET_3131	COG1028	Short-chain dehydrogenase reductase Sdr
MRET_3131	COG0604	alcohol dehydrogenase
MRET_3134	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
MRET_3144	COG0484	heat shock protein binding
MRET_3145	COG0101	tRNA pseudouridine synthase activity
MRET_3154	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
MRET_3173	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MRET_3177	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
MRET_3178	COG0085	RNA polymerase activity
MRET_3183	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
MRET_3196	COG2815	serine threonine protein kinase
MRET_3196	COG0515	serine threonine protein kinase
MRET_3200	COG0515	serine threonine protein kinase
MRET_3200	COG2815	serine threonine protein kinase
MRET_3212	COG0515	serine threonine protein kinase
MRET_3212	COG2815	serine threonine protein kinase
MRET_3229	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
MRET_3234	COG0527	aspartate kinase activity
MRET_3234	COG0460	homoserine dehydrogenase
MRET_3239	COG0222	ribosome binding
MRET_3261	COG0154	amidase activity
MRET_3267	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MRET_3278	COG4221	oxidoreductase activity
MRET_3280	COG0109	protoheme IX farnesyltransferase activity
MRET_3302	COG0513	Belongs to the DEAD box helicase family
MRET_3309	COG0617	tRNA 3'-terminal CCA addition
MRET_3310	COG0515	serine threonine protein kinase
MRET_3318	COG1183	phosphatidylcholine synthase activity
MRET_3321	COG0277	FAD linked oxidase domain protein
MRET_3327	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
MRET_3342	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
MRET_3382	COG0488	(ABC) transporter
MRET_3383	COG0488	(ABC) transporter
MRET_3386	COG0488	(ABC) transporter
MRET_3410	COG0025	NhaP-type Na H and K H
MRET_3426	COG1228	amidohydrolase
MRET_3434	COG3425	synthase
MRET_3436	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MRET_3437	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MRET_3443	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
MRET_3448	COG0443	Heat shock 70 kDa protein
MRET_3449	COG0194	GDP metabolic process
MRET_3458	COG0261	This protein binds to 23S rRNA in the presence of protein L20
MRET_3473	COG2226	methyltransferase
MRET_3475	COG0167	dihydroorotate dehydrogenase activity
MRET_3477	COG1196	nuclear chromosome segregation
MRET_3483	COG0656	L-ascorbic acid biosynthetic process
MRET_3484	COG0656	L-ascorbic acid biosynthetic process
MRET_3485	COG0656	L-ascorbic acid biosynthetic process
MRET_3487	COG0423	glycine-tRNA ligase activity
MRET_3500	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
MRET_3502	COG2759	Belongs to the formate--tetrahydrofolate ligase family
MRET_3520	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
MRET_3528	COG0180	Tryptophanyl-tRNA synthetase
MRET_3545	COG0051	transcription antitermination factor activity, RNA binding
MRET_3549	COG0463	Glycosyl transferase, family 2
MRET_3554	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MRET_3557	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
MRET_3565	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
MRET_3580	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
MRET_3599	COG1017	nitric oxide dioxygenase activity
MRET_3599	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
MRET_3600	COG0724	RNA recognition motif
MRET_3601	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
MRET_3603	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
MRET_3610	COG0473	3-isopropylmalate dehydrogenase activity
MRET_3612	COG2895	sulfate adenylyltransferase (ATP) activity
MRET_3617	COG0204	Acyl-transferase
MRET_3622	COG0542	response to heat
MRET_3626	COG0515	serine threonine protein kinase
MRET_3627	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
MRET_3631	COG1028	Short-chain dehydrogenase reductase Sdr
MRET_3632	COG0822	iron-sulfur transferase activity
MRET_3653	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
MRET_3656	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
MRET_3661	COG2895	sulfate adenylyltransferase (ATP) activity
MRET_3670	COG0515	serine threonine protein kinase
MRET_3670	COG2815	serine threonine protein kinase
MRET_3677	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
MRET_3678	COG0156	8-amino-7-oxononanoate synthase activity
MRET_3689	COG1063	alcohol dehydrogenase
MRET_3701	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MRET_3718	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MRET_3719	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
MRET_3741	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MRET_3742	COG1028	Short-chain dehydrogenase reductase Sdr
MRET_3752	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
MRET_3754	COG1444	tRNA N-acetyltransferase activity
MRET_3765	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
MRET_3771	COG0415	Belongs to the DNA photolyase family
MRET_3775	COG2814	Major facilitator Superfamily
MRET_3789	COG1185	polyribonucleotide nucleotidyltransferase activity
MRET_3821	COG0515	serine threonine protein kinase
MRET_3824	COG2890	protein-(glutamine-N5) methyltransferase activity
MRET_3833	COG0387	Pfam Sodium calcium exchanger
MRET_3835	COG0004	ammonium transporteR
MRET_3836	COG0585	pseudouridine synthase activity
MRET_3851	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
MRET_3853	COG0501	Belongs to the peptidase M48B family
MRET_3854	COG1793	dna ligase
MRET_3855	COG1196	nuclear chromosome segregation
MRET_3870	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
MRET_3883	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
MRET_3885	COG0523	cobalamin synthesis protein
MRET_3906	COG0488	(ABC) transporter
MRET_3919	COG0484	heat shock protein binding
MRET_3938	COG0481	GTPase activity
MRET_3961	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
MRET_3963	COG1960	acyl-CoA dehydrogenase activity
MRET_3966	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
MRET_3974	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
MRET_3985	COG0028	Belongs to the TPP enzyme family
MRET_3994	COG3240	lipase activity
MRET_3997	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
MRET_3998	COG0513	Belongs to the DEAD box helicase family
MRET_4003	COG1129	ABC transporter
MRET_4007	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
MRET_4011	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MRET_4013	COG1025	Belongs to the peptidase M16 family
MRET_4019	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
MRET_4021	COG0183	Belongs to the thiolase family
MRET_4025	COG0352	thiamine-phosphate diphosphorylase activity
MRET_4025	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
MRET_4025	COG0351	phosphomethylpyrimidine kinase
MRET_4028	COG0326	Molecular chaperone. Has ATPase activity
MRET_4045	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MRET_4046	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
MRET_4073	COG2814	Major facilitator Superfamily
MRET_4073	COG0477	Major facilitator Superfamily
MRET_4076	COG0484	heat shock protein binding
MRET_4089	COG1012	belongs to the aldehyde dehydrogenase family
MRET_4094	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
MRET_4113	COG0175	sulfate reduction
MRET_4116	COG0492	ferredoxin-NADP+ reductase activity
MRET_4120	COG0724	RNA recognition motif
MRET_4125	COG2815	serine threonine protein kinase
MRET_4125	COG0515	serine threonine protein kinase
MRET_4132	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
MRET_4142	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
MRET_4151	COG0515	serine threonine protein kinase
MRET_4158	COG0525	valine-tRNA ligase activity
MRET_4173	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
MRET_4178	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
MRET_4179	COG0085	RNA polymerase activity
MRET_4192	COG0784	Response regulator, receiver
MRET_4192	COG2205	protein histidine kinase activity
MRET_4192	COG5002	protein histidine kinase activity
MRET_4198	COG5265	(ABC) transporter
MRET_4205	COG1394	ATPase activity, coupled to movement of substances
MRET_4207	COG0563	adenylate kinase activity
MRET_4210	COG0515	serine threonine protein kinase
MRET_4212	COG0517	IMP dehydrogenase activity
MRET_4212	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
MRET_4216	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MRET_4221	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
MRET_4222	COG1132	(ABC) transporter
MRET_4231	COG0756	dUTP diphosphatase activity
MRET_4237	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
MRET_4238	COG0417	DNA replication proofreading
MRET_4243	COG2072	flavoprotein involved in K transport
MRET_4251	COG0656	L-ascorbic acid biosynthetic process
MRET_4268	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
MRET_4279	COG0667	Aldo Keto reductase
MRET_4284	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
MRET_4285	COG0484	heat shock protein binding
MRET_4294	COG1643	Atp-dependent helicase
MRET_4297	COG0017	Asparaginyl-tRNA synthetase
MRET_4298	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
MRET_4301	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MRET_4312	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MRET_4314	COG0489	protein tyrosine kinase activity
MRET_4315	COG0563	adenylate kinase activity
MRET_4316	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MRET_4318	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MRET_4318	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MRET_4319	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
MRET_4320	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MRET_4322	COG0183	Belongs to the thiolase family
MRET_4334	COG0543	2 iron, 2 sulfur cluster binding
MRET_4334	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
MRET_4339	COG0367	asparagine synthase
MRET_4350	COG0563	adenylate kinase activity
MRET_4357	COG0509	glycine decarboxylation via glycine cleavage system
MRET_4369	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MRET_4385	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA