locus-tag class description KU6B_RS00005 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) KU6B_RS00015 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) KU6B_RS00025 ENOG410756H nucleotidyltransferase KU6B_RS00040 ENOG4105D7T ABC transporter KU6B_RS00045 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component KU6B_RS00055 ENOG4105E9K Isocitrate dehydrogenase KU6B_RS00060 ENOG4105KJM monovalent cation h antiporter subunit g KU6B_RS00065 ENOG4105W4C monovalent cation H antiporter subunit F KU6B_RS00070 ENOG4105SC1 monovalent cation H antiporter subunit E KU6B_RS00075 ENOG4107R4Z monovalent cation h antiporter subunit d KU6B_RS00080 ENOG4108ZE9 Monovalent cation H antiporter subunit C KU6B_RS00090 ENOG4105C1B dTDP-glucose 4-6-dehydratase KU6B_RS00100 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein KU6B_RS00105 ENOG4105E0C molybdate abc transporter KU6B_RS00110 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) KU6B_RS00120 ENOG4105EXX Deoxyribodipyrimidine photolyase-related protein KU6B_RS00130 ENOG4108KX4 response regulator KU6B_RS00145 ENOG4105C4K Nad synthetase KU6B_RS00155 ENOG4107XID 2'-5' rna ligase KU6B_RS00165 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) KU6B_RS00175 ENOG4105KPV Transcriptional regulator KU6B_RS00180 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) KU6B_RS00185 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) KU6B_RS00195 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor KU6B_RS00210 ENOG4107TK4 histidinol-phosphate phosphatase KU6B_RS00220 ENOG4108I0Y (ABC) transporter KU6B_RS00225 ENOG4108UJV acyl-CoA thioesterase i KU6B_RS00235 ENOG4105P52 geranylgeranyl reductase KU6B_RS00240 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein KU6B_RS00260 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) KU6B_RS00270 ENOG4105DD5 Flagellar motor switch protein KU6B_RS00275 ENOG4105CN7 Flagellar biosynthetic protein FliP KU6B_RS00280 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) KU6B_RS00285 ENOG4105C72 UPF0176 protein KU6B_RS00290 ENOG4105R8A Heat shock protein KU6B_RS00295 ENOG4108RWI nicotinamidase KU6B_RS00300 ENOG4107RH7 Nicotinate phosphoribosyltransferase KU6B_RS00305 ENOG4105EXC Acyl-transferase KU6B_RS00315 ENOG4105CIH Imidazole acetol-phosphate transaminase KU6B_RS00330 ENOG4107S78 Band 7 protein KU6B_RS00335 ENOG4105PV3 Inner membrane protein yqiJ KU6B_RS00345 ENOG4107ZT5 Thiol disulfide interchange protein KU6B_RS00350 ENOG4105CH7 arginosuccinase KU6B_RS00380 ENOG4108YZN class I peptide chain release factor KU6B_RS00385 ENOG4105EX9 Membrane KU6B_RS00395 ENOG4105HPZ Involved in the removal of murein from the sacculus. May also facilitate integration of nascent murein strands into the sacculus by cleaving the peptide bonds between neighboring strands in mature murein (By similarity) KU6B_RS00415 ENOG4105C9U ATP-dependent DNA helicase RecQ KU6B_RS00420 ENOG4105D1Q UPF0246 protein KU6B_RS00425 ENOG4105BZU Histidine kinase KU6B_RS00465 ENOG4108ZEY Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) KU6B_RS00470 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) KU6B_RS00475 ENOG4105CHU acetyl-coa acetyltransferase KU6B_RS00485 ENOG4105EGS Mechanosensitive ion channel KU6B_RS00490 ENOG4105C6T cysteine synthase KU6B_RS00500 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) KU6B_RS00510 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) KU6B_RS00530 ENOG4105ETT transcriptional Regulator, LysR family KU6B_RS00535 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) KU6B_RS00545 ENOG4105DJP Membrane KU6B_RS00555 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) KU6B_RS00630 ENOG4107Y80 Major Facilitator superfamily KU6B_RS00645 ENOG4108M4U conserved membrane protein KU6B_RS00670 ENOG4108N5C SNARE associated Golgi protein-related protein KU6B_RS00695 ENOG4105E0F Histidine kinase KU6B_RS00750 ENOG4105CVR type I restriction-modification system KU6B_RS00765 ENOG4105DZR Type I site-specific deoxyribonuclease KU6B_RS00770 ENOG4105DUM transcriptional regulator, lysR family KU6B_RS00775 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F KU6B_RS00800 ENOG4105KCV RNA signal recognition particle 4.5S RNA KU6B_RS00805 ENOG4105CYM Glutathione S-transferase KU6B_RS00810 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) KU6B_RS00825 ENOG4105KK4 UPF0060 membrane protein KU6B_RS00830 ENOG4105W1Y Transcriptional regulator KU6B_RS00845 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) KU6B_RS00860 ENOG4105D6J arsenicaL-resistance protein KU6B_RS00865 ENOG4105CHR reductase KU6B_RS00870 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 KU6B_RS00875 ENOG4108RTU Aldolase KU6B_RS00880 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) KU6B_RS00910 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs KU6B_RS00935 ENOG4107QPD alcohol dehydrogenase KU6B_RS00975 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) KU6B_RS00980 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase KU6B_RS00995 ENOG4105D6Z AFG1 family ATPase KU6B_RS01005 ENOG4105DCM major facilitator superfamily KU6B_RS01010 ENOG4108J2P Alpha beta hydrolase fold KU6B_RS01015 ENOG4105CIF Ornithine Cyclodeaminase KU6B_RS01025 ENOG4108UPT UPF0178 protein KU6B_RS01030 ENOG4105C4W S-formylglutathione hydrolase KU6B_RS01050 ENOG4105C01 Dihydroxy-acid dehydratase KU6B_RS01075 ENOG4105CJP fad dependent oxidoreductase KU6B_RS01080 ENOG4105D38 putrescine abc transporter KU6B_RS01085 ENOG4105F38 ABC transporter, permease KU6B_RS01090 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) KU6B_RS01105 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) KU6B_RS01115 ENOG4105K8Z Phage shock protein KU6B_RS01120 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) KU6B_RS01140 ENOG4107QSN dihydrolipoamide acetyltransferase KU6B_RS01145 ENOG4107QN2 dihydrolipoyl dehydrogenase KU6B_RS01150 ENOG4108NIX Factor ChrR KU6B_RS01155 ENOG4105K6V RNA polymerase KU6B_RS01175 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr KU6B_RS01185 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) KU6B_RS01210 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) KU6B_RS01250 ENOG4105DY8 decarboxylase KU6B_RS01255 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) KU6B_RS01260 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) KU6B_RS01310 ENOG4105E3A (ABC) transporter KU6B_RS01335 ENOG4107104 thymidine kinase KU6B_RS01365 ENOG4108Z7R Chaperone CsaA KU6B_RS01370 ENOG4105II7 pyrroline-5-carboxylate reductase KU6B_RS01385 ENOG4105DDW LysR family Transcriptional regulator KU6B_RS01390 ENOG41072AC 4-hydroxybenzoate 3-monooxygenase KU6B_RS01400 ENOG4105EU7 Protocatechuate 3,4-dioxygenase, beta KU6B_RS01405 ENOG4105RM9 Protocatechuate 3,4-dioxygenase alpha KU6B_RS01425 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase KU6B_RS01430 ENOG4105E3W Two component transcriptional regulator (Winged helix family KU6B_RS01435 ENOG4105EB3 Histidine kinase KU6B_RS01445 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) KU6B_RS01455 ENOG41080Z8 PHOSPHOCARRIER protein KU6B_RS01465 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase KU6B_RS01480 ENOG4105TPV KU6B_RS01485 ENOG4105D0M Protease HtpX homolog KU6B_RS01495 ENOG4108K0D peptidase, M48 KU6B_RS01505 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) KU6B_RS01515 ENOG4105E1F short-chain dehydrogenase reductase KU6B_RS01525 ENOG4108WBT adenosyltransferase KU6B_RS01540 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) KU6B_RS01630 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) KU6B_RS01640 ENOG4105ETT transcriptional Regulator, LysR family KU6B_RS01650 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) KU6B_RS01655 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) KU6B_RS01665 ENOG4105BZU Histidine kinase KU6B_RS01675 ENOG4108VZM 50s ribosomal protein L10 KU6B_RS01680 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) KU6B_RS01685 ENOG4107QIH DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) KU6B_RS01690 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) KU6B_RS01705 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) KU6B_RS01710 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) KU6B_RS01715 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) KU6B_RS01720 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) KU6B_RS01725 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) KU6B_RS01730 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) KU6B_RS01735 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) KU6B_RS01740 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) KU6B_RS01755 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) KU6B_RS01760 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) KU6B_RS01770 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) KU6B_RS01805 ENOG41083MP 50s ribosomal protein l29 KU6B_RS01810 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal KU6B_RS01815 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) KU6B_RS01820 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) KU6B_RS01825 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits KU6B_RS01830 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) KU6B_RS01835 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) KU6B_RS01840 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) KU6B_RS01845 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) KU6B_RS01855 ENOG41084HQ 50S ribosomal protein L30 KU6B_RS01860 ENOG4105E8R UPF0173 metal-dependent hydrolase KU6B_RS01865 ENOG4106A3M Cytochrome p-450 KU6B_RS01875 ENOG4105C1J atp-dependent rna helicase KU6B_RS01885 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) KU6B_RS01890 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) KU6B_RS01895 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) KU6B_RS01905 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits KU6B_RS01910 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) KU6B_RS01915 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) KU6B_RS01920 ENOG4108ZT0 50S ribosomal protein l17 KU6B_RS01930 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) KU6B_RS01935 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) KU6B_RS01950 ENOG4105D1N poly(r)-hydroxyalkanoic acid synthase, class KU6B_RS01970 ENOG4105FKN transcriptional regulator, AsnC family KU6B_RS01980 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase KU6B_RS01990 ENOG4105BZU Histidine kinase KU6B_RS02020 ENOG4107QVT Binding-protein-dependent transport systems, inner membrane component KU6B_RS02055 ENOG4105EXC Acyl-transferase KU6B_RS02060 ENOG4105EXC Acyl-transferase KU6B_RS02065 ENOG4105EXC Acyl-transferase KU6B_RS02085 ENOG4105C30 Nad-dependent epimerase dehydratase KU6B_RS02100 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family KU6B_RS02105 ENOG4105DFA alanine racemase domain protein KU6B_RS02110 ENOG4107RDJ Sulfotransferase KU6B_RS02120 ENOG4105TXM Domain of unknown function (DUF3576) KU6B_RS02125 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) KU6B_RS02130 ENOG4105C8T Leucyl-tRNA synthetase KU6B_RS02155 ENOG4105GQU Trap dicarboxylate transporter, dctp subunit KU6B_RS02160 ENOG4105CG6 trap dicarboxylate transporter dctm subunit KU6B_RS02185 ENOG4107SQD Transcriptional regulator, GntR family KU6B_RS02195 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) KU6B_RS02210 ENOG4105ETE Transcriptional regulator (LacI family KU6B_RS02220 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component KU6B_RS02235 ENOG4105CHR reductase KU6B_RS02240 ENOG4105DEI Mannitol dehydrogenase KU6B_RS02260 ENOG4105D7T ABC transporter KU6B_RS02275 ENOG4108IFG nitrite reductase, (NAD(P)H) KU6B_RS02280 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit KU6B_RS02290 ENOG4107S1N anthranilate phosphoribosyltransferase KU6B_RS02295 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) KU6B_RS02305 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase KU6B_RS02315 ENOG4107RUE extracellular solute-binding protein family 1 KU6B_RS02320 ENOG4105D38 putrescine abc transporter KU6B_RS02325 ENOG4105F38 ABC transporter, permease KU6B_RS02330 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) KU6B_RS02335 ENOG4105CWC Acetylornithine deacetylase KU6B_RS02350 ENOG4107R11 Transcriptional regulator KU6B_RS02360 ENOG4105KME endoribonuclease L-psp KU6B_RS02365 ENOG4105H3G oxidoreductase KU6B_RS02375 ENOG4105CYB regulatoR KU6B_RS02395 ENOG4105S0E allantoin catabolism protein KU6B_RS02410 ENOG4108Z2U ureidoglycolate hydrolase KU6B_RS02415 ENOG4105FFA Catalyzes the oxidation of uric acid to 5- hydroxyisourate, which is further processed to form (S)-allantoin (By similarity) KU6B_RS02425 ENOG4105CC0 LysR family Transcriptional regulator KU6B_RS02435 ENOG4108EQM faD-dependent pyridine nucleotide-disulfide oxidoreductase KU6B_RS02440 ENOG4108V7B Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide (By similarity) KU6B_RS02445 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) KU6B_RS02470 ENOG4105E2Y ABC, transporter KU6B_RS02475 ENOG4108RZE Tetr family transcriptional regulator KU6B_RS02505 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) KU6B_RS02515 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) KU6B_RS02560 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) KU6B_RS02580 ENOG4105CMT Dihydroxyacetone kinase KU6B_RS02595 ENOG4108YZG isomerase KU6B_RS02600 ENOG4105CP7 Triose-phosphate isomerase KU6B_RS02610 ENOG4105CV1 Transketolase (EC 2.2.1.1) KU6B_RS02625 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) KU6B_RS02640 ENOG410908U Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) KU6B_RS02650 ENOG4105C6V Glycerol-3-phosphate dehydrogenase KU6B_RS02665 ENOG4105C2J ABC transporter KU6B_RS02670 ENOG4105CNN ABC, transporter KU6B_RS02675 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator KU6B_RS02680 ENOG410811B TRANSCRIPTIONal KU6B_RS02685 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) KU6B_RS02715 ENOG4105D3W isochorismatase KU6B_RS02725 ENOG4108ZX5 transcriptional regulator KU6B_RS02750 ENOG4108KB2 LysR family Transcriptional regulator KU6B_RS02760 ENOG4107QIZ NADH dehydrogenase KU6B_RS02765 ENOG4108IEG Formate dehydrogenase Alpha subunit KU6B_RS02770 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) KU6B_RS02790 ENOG4105EHG Permease protein KU6B_RS02795 ENOG4105E0A ABC, transporter KU6B_RS02800 ENOG4105D38 putrescine abc transporter KU6B_RS02815 ENOG4107RUE extracellular solute-binding protein family 1 KU6B_RS02825 ENOG4105C26 Dehydrogenase KU6B_RS02840 ENOG4105CG6 trap dicarboxylate transporter dctm subunit KU6B_RS02860 ENOG4107EJG GntR family transcriptional regulator KU6B_RS02870 ENOG4107R9N ABC transporter KU6B_RS02875 ENOG4105C2J ABC transporter KU6B_RS02880 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator KU6B_RS02885 ENOG4106NZI LysR family Transcriptional regulator KU6B_RS02925 ENOG4105CG6 trap dicarboxylate transporter dctm subunit KU6B_RS02930 ENOG4107Y2X deaminase KU6B_RS02935 ENOG4108JQ7 (ABC) transporter KU6B_RS02940 ENOG4105C3U ABC transporter KU6B_RS02945 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) KU6B_RS02955 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component KU6B_RS02960 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component KU6B_RS02965 ENOG4105DEF Extracellular solute-binding protein, family 5 KU6B_RS02970 ENOG4107YCY Transcriptional regulator KU6B_RS02980 ENOG4105ETE Transcriptional regulator (LacI family KU6B_RS03000 ENOG4105C2J ABC transporter KU6B_RS03005 ENOG4105CNN ABC, transporter KU6B_RS03010 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane KU6B_RS03025 ENOG4105EVH UPF0753 protein KU6B_RS03030 ENOG4105D65 subunit l KU6B_RS03055 ENOG4108RYR transcriptional regulator AsnC family KU6B_RS03065 ENOG4105C26 Dehydrogenase KU6B_RS03105 ENOG4105C7R Atpase associated with various cellular activities aaa_3 KU6B_RS03110 ENOG4105CRW Short chain fatty acid transporter KU6B_RS03115 ENOG4105DV0 amidase (EC 3.5.1.4 KU6B_RS03120 ENOG4105CEY Amp-dependent synthetase and ligase KU6B_RS03140 ENOG4105K56 Transcriptional regulator KU6B_RS03150 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) KU6B_RS03175 ENOG4105RE0 Asp Glu hydantoin racemase KU6B_RS03190 ENOG4108UAU isochorismatase KU6B_RS03195 ENOG4105MSY salicylate hydroxylase KU6B_RS03210 ENOG4105UIB (ABC) transporter KU6B_RS03215 ENOG4108JQ9 ABC transporter KU6B_RS03295 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) KU6B_RS03300 ENOG4107SPB Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) KU6B_RS03305 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase KU6B_RS03310 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) KU6B_RS03350 ENOG4108RG0 uracil-dna glycosylase KU6B_RS03385 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) KU6B_RS03400 ENOG4106517 Short-chain dehydrogenase reductase Sdr KU6B_RS03410 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component KU6B_RS03435 ENOG4105DEF Extracellular solute-binding protein, family 5 KU6B_RS03440 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) KU6B_RS03445 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) KU6B_RS03450 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) KU6B_RS03490 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) KU6B_RS03500 ENOG4105E3N F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) KU6B_RS03505 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) KU6B_RS03510 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) KU6B_RS03515 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) KU6B_RS03520 ENOG4107ZDE Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) KU6B_RS03530 ENOG41076UM multiple antibiotic resistance (MarC)-related protein KU6B_RS03555 ENOG4105EBM Alpha Beta Hydrolase Fold protein KU6B_RS03560 ENOG4105E3A (ABC) transporter KU6B_RS03565 ENOG4105DA5 (ABC) transporter KU6B_RS03570 ENOG4108SXK Transporter Drug Metabolite Exporter family KU6B_RS03585 ENOG4105GVR general secretion pathway protein D KU6B_RS03595 ENOG4107QHF type ii secretion system protein e KU6B_RS03600 ENOG4105D7Q type ii secretion system KU6B_RS03640 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) KU6B_RS03645 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) KU6B_RS03685 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) KU6B_RS03695 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase KU6B_RS03700 ENOG4108Z0Z intracellular protease Pfpi family KU6B_RS03710 ENOG4105HEI LysR family (Transcriptional regulator KU6B_RS03730 ENOG4108I62 cina-like protein KU6B_RS03735 ENOG4105PW4 Sugar fermentation stimulation protein homolog KU6B_RS03740 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase KU6B_RS03745 ENOG4105EEF Alkane 1-monooxygenase KU6B_RS03750 ENOG4105CEN a g-specific adenine glycosylase KU6B_RS03765 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F KU6B_RS03790 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) KU6B_RS03800 ENOG4107U32 Beta-lactamase domain protein KU6B_RS03805 ENOG4106H78 methyltransferase KU6B_RS03820 ENOG4105KZX Pterin carbinolamine dehydratase KU6B_RS03830 ENOG4108QXE glycerophosphoryl diester phosphodiesterase KU6B_RS03865 ENOG4105BZ4 penicillin-binding protein KU6B_RS03870 ENOG4108YZA Nitrogen regulatory protein pii KU6B_RS03885 ENOG41073TP transcriptional regulator KU6B_RS03890 ENOG4108ZAF Molybdopterin KU6B_RS03900 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase KU6B_RS03920 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) KU6B_RS03930 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) KU6B_RS03935 ENOG4105C3F Signal peptidase i KU6B_RS03945 ENOG4105C3F Signal peptidase i KU6B_RS03955 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) KU6B_RS03970 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) KU6B_RS03980 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) KU6B_RS03985 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) KU6B_RS04000 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) KU6B_RS04020 ENOG4105EN6 Membrane KU6B_RS04025 ENOG4105C87 Aminotransferase class I and II KU6B_RS04030 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) KU6B_RS04035 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) KU6B_RS04040 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) KU6B_RS04045 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) KU6B_RS04060 ENOG4105CHF Glutathione S-transferase KU6B_RS04100 ENOG4108IJ7 Glycine betaine KU6B_RS04120 ENOG4105CHR reductase KU6B_RS04135 ENOG4105CHM Aminotransferase KU6B_RS04170 ENOG4108ZZ3 UPF0260 protein KU6B_RS04190 ENOG4105CA9 Pyruvate kinase KU6B_RS04200 ENOG4105DSF transport protein KU6B_RS04205 ENOG41082BR 50S ribosomal protein L35 KU6B_RS04210 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) KU6B_RS04230 ENOG4108NH8 Cation transport protein KU6B_RS04235 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) KU6B_RS04255 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) KU6B_RS04275 ENOG4105C1G acyl-Coa dehydrogenase KU6B_RS04335 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) KU6B_RS04350 ENOG4105EW9 transcriptional regulator AsnC family KU6B_RS04370 ENOG4107S8C mandelate racemase muconate lactonizing KU6B_RS04400 ENOG4107YD3 Thioesterase KU6B_RS04410 ENOG4105E02 MotA TolQ exbB proton channel KU6B_RS04415 ENOG4105M8F Biopolymer transport protein exbD tolR KU6B_RS04435 ENOG4105KCK Peptidoglycan-associated lipoprotein KU6B_RS04445 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) KU6B_RS04450 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) KU6B_RS04465 ENOG4105CKU formyltetrahydrofolate synthetase KU6B_RS04480 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) KU6B_RS04485 ENOG4105CMR udp-glucose 4-epimerase KU6B_RS04525 ENOG4105CPC Aldo Keto reductase KU6B_RS04555 ENOG4105UIB (ABC) transporter KU6B_RS04560 ENOG4105C2J ABC transporter KU6B_RS04595 ENOG4105C0R drug resistance transporter emrb qaca subfamily KU6B_RS04620 ENOG4105CUT histidyl-tRNA synthetase KU6B_RS04625 ENOG4105P5X ATP phosphoribosyltransferase regulatory subunit KU6B_RS04630 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) KU6B_RS04635 ENOG4105CYM Glutathione S-transferase KU6B_RS04665 ENOG4105CPN adenine deaminase KU6B_RS04680 ENOG4108M0I Transcriptional regulator KU6B_RS04720 ENOG4105CKI cobalamin synthesis protein KU6B_RS04735 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) KU6B_RS04755 ENOG4105D7T ABC transporter KU6B_RS04780 ENOG4105DSE periplasmic solute binding protein KU6B_RS04785 ENOG4105DIK (ABC) transporter KU6B_RS04795 ENOG4107RBD ABC, transporter KU6B_RS04810 ENOG41074H6 response regulator KU6B_RS04840 ENOG4108Z86 Glutamine amidotransferase KU6B_RS04845 ENOG4105VDW Csbd family KU6B_RS04865 ENOG410903D sensor protein KU6B_RS04895 ENOG4105DSF transport protein KU6B_RS04915 ENOG4105CS9 pantothenic acid kinase KU6B_RS04925 ENOG4105C3Q Glycosyl transferase, family 2 KU6B_RS04930 ENOG4107NQ8 LysR family Transcriptional regulator KU6B_RS04935 ENOG4105F38 ABC transporter, permease KU6B_RS04940 ENOG4108EG7 Binding-protein-dependent transport systems, inner membrane component KU6B_RS04950 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) KU6B_RS04955 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) KU6B_RS04960 ENOG4105DE9 3-keto-5-aminohexanoate cleavage enzyme KU6B_RS04975 ENOG4105FC8 fad dependent oxidoreductase KU6B_RS04990 ENOG4107YV9 domain protein KU6B_RS04995 ENOG4105C7W Xanthine dehydrogenase KU6B_RS05010 ENOG4107QUY Guanine deaminase KU6B_RS05080 ENOG4105DDR sarcosine oxidase (Beta subunit) KU6B_RS05090 ENOG4105WIU sarcosine oxidase delta subunit KU6B_RS05095 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) KU6B_RS05110 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) KU6B_RS05115 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) KU6B_RS05145 ENOG4107RT5 aminobenzoyl-glutamate utilization protein B KU6B_RS05155 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) KU6B_RS05160 ENOG4105E12 capsule polysaccharide KU6B_RS05170 ENOG41084CK capsule polysaccharide KU6B_RS05180 ENOG4105CUC YeeE YedE family protein KU6B_RS05195 ENOG4107QIV Cytochrome c biogenesis protein KU6B_RS05225 ENOG4105CGH 5'-nucleotidase KU6B_RS05245 ENOG4107S7U Sulfide dehydrogenase KU6B_RS05260 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) KU6B_RS05265 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) KU6B_RS05295 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) KU6B_RS05300 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase KU6B_RS05320 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) KU6B_RS05325 ENOG4108IV0 ABC, transporter KU6B_RS05330 ENOG4105C0Z ABC transporter KU6B_RS05340 ENOG4105C32 Amino acid ABC transporter (Permease) KU6B_RS05350 ENOG4105CFF transcriptional regulator KU6B_RS05355 ENOG4105CK6 Two component transcriptional regulator (Winged helix family KU6B_RS05365 ENOG4105BZU Histidine kinase KU6B_RS05410 ENOG4105Y2X UPF0335 protein KU6B_RS05485 ENOG4105E2X shikimate dehydrogenase KU6B_RS05490 ENOG410846T CoA-transferase family III KU6B_RS05505 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) KU6B_RS05555 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component KU6B_RS05560 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component KU6B_RS05570 ENOG4108WAV Transcriptional regulator KU6B_RS05575 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) KU6B_RS05610 ENOG4105ECQ AraC Family Transcriptional Regulator KU6B_RS05615 ENOG4105MP9 class II Aldolase KU6B_RS05625 ENOG4105BZS acriflavin resistance protein KU6B_RS05630 ENOG4105C1P efflux transporter, rnd family, mfp subunit KU6B_RS05635 ENOG4108ERU trap dicarboxylate transporter subunit DctP KU6B_RS05650 ENOG4105C45 hydrogenase expression formation protein (HypE) KU6B_RS05655 ENOG4105CQS hydrogenase expression formation protein HypD KU6B_RS05660 ENOG41082MF Hydrogenase assembly chaperone hypC hupF KU6B_RS05665 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family KU6B_RS05670 ENOG4107RSS Hydrogenase accessory protein HypB KU6B_RS05675 ENOG4105WMM Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) KU6B_RS05680 ENOG4108ZBK Inherit from NOG: hydrogenase expression formation protein HupK KU6B_RS05685 ENOG410631X Hydrogenase expression formation protein KU6B_RS05690 ENOG4108UT5 Hydrogenase expression KU6B_RS05695 ENOG4105YYZ Hydrogenase expression formation protein KU6B_RS05700 ENOG4105X9Y Hydrogenase assembly chaperone hypC hupF KU6B_RS05705 ENOG4108USZ hydrogenase KU6B_RS05710 ENOG4105X7T Ni Fe-hydrogenase, b-type cytochrome subunit KU6B_RS05720 ENOG4105DPX Hydrogenase, large subunit KU6B_RS05725 ENOG4105E3S small subunit KU6B_RS05730 ENOG4105C8H hydrogenase maturation protein Hypf KU6B_RS05735 ENOG4105E3S small subunit KU6B_RS05755 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component KU6B_RS05765 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) KU6B_RS05770 ENOG4105RQF LysR family Transcriptional regulator KU6B_RS05775 ENOG4105DEF Extracellular solute-binding protein, family 5 KU6B_RS05785 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component KU6B_RS05790 ENOG4105C3U ABC transporter KU6B_RS05800 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) KU6B_RS05805 ENOG4107RT5 aminobenzoyl-glutamate utilization protein B KU6B_RS05810 ENOG4105CT3 Monooxygenase KU6B_RS05815 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family KU6B_RS05820 ENOG4105C7K acetolactate synthase KU6B_RS05830 ENOG4107S78 Band 7 protein KU6B_RS05845 ENOG4105C0Z ABC transporter KU6B_RS05855 ENOG4105C32 Amino acid ABC transporter (Permease) KU6B_RS05860 ENOG4105CP9 extracellular ligand-binding receptor KU6B_RS05885 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase KU6B_RS05895 ENOG4108VRQ UPF0314 protein KU6B_RS05900 ENOG4105ERH Fumarylacetoacetate hydrolase KU6B_RS05905 ENOG4105F1J Homogentisate 1,2-dioxygenase KU6B_RS05910 ENOG4108RXX maleylacetoacetate isomerase KU6B_RS05915 ENOG4105C8Y Acetylornithine aminotransferase KU6B_RS05940 ENOG4105C26 Dehydrogenase KU6B_RS05945 ENOG4105EQN UPF0261 protein KU6B_RS06035 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) KU6B_RS06040 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) KU6B_RS06045 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) KU6B_RS06055 ENOG4108VYJ response regulator receiver protein KU6B_RS06060 ENOG4105BZU Histidine kinase KU6B_RS06065 ENOG4108V3W Chemotaxis protein, CheW KU6B_RS06070 ENOG4105CBS Chea signal transduction histidine kinase KU6B_RS06075 ENOG4108VYJ response regulator receiver protein KU6B_RS06125 ENOG4108JQ6 ABC transporter KU6B_RS06130 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component KU6B_RS06135 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component KU6B_RS06140 ENOG4105DEF Extracellular solute-binding protein, family 5 KU6B_RS06175 ENOG4105CHU acetyl-coa acetyltransferase KU6B_RS06185 ENOG4105C1G acyl-Coa dehydrogenase KU6B_RS06195 ENOG4105CSU acyl-Coa dehydrogenase KU6B_RS06230 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) KU6B_RS06275 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) KU6B_RS06290 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) KU6B_RS06300 ENOG4105DMF Dehydrogenase KU6B_RS06310 ENOG4105BZU Histidine kinase KU6B_RS06315 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) KU6B_RS06320 ENOG4105CSR polyphosphate kinase 2 KU6B_RS06330 ENOG4107QI1 Mate efflux family protein KU6B_RS06340 ENOG4105C3G gtp-binding protein KU6B_RS06365 ENOG4105DY2 Paraquat-inducible protein b KU6B_RS06370 ENOG4105F1S paraquat-inducible protein a KU6B_RS06395 ENOG4105HMI Membrane KU6B_RS06465 ENOG4108Z4U Ferredoxin KU6B_RS06470 ENOG4105DP0 ferredoxin-NADP reductase KU6B_RS06525 ENOG4105FDP GntR family transcriptional regulator KU6B_RS06530 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase KU6B_RS06535 ENOG4105CHU acetyl-coa acetyltransferase KU6B_RS06545 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family KU6B_RS06550 ENOG4105C01 Dihydroxy-acid dehydratase KU6B_RS06555 ENOG41060WC Enoyl-CoA hydratase KU6B_RS06560 ENOG4105EW6 flavin reductase domain protein, FMN-binding KU6B_RS06575 ENOG4105F2Z 3-oxoadipate enol-lactonase KU6B_RS06590 ENOG4105CC9 acyl-Coa dehydrogenase KU6B_RS06595 ENOG4108RK3 acyl-Coa dehydrogenase KU6B_RS06610 ENOG4105C1J atp-dependent rna helicase KU6B_RS06620 ENOG4105EMF GntR family transcriptional regulator KU6B_RS06625 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) KU6B_RS06645 ENOG410633P Hydantoin racemase KU6B_RS06655 ENOG41079YP Citrate utilization protein b KU6B_RS06665 ENOG4105DRR Transcriptional regulator, GntR family KU6B_RS06670 ENOG4108KTG Membrane protein, drug metabolite transporter KU6B_RS06680 ENOG4105CS1 NAD(P)H quinone oxidoreductase KU6B_RS06740 ENOG4105BZU Histidine kinase KU6B_RS06755 ENOG4105CG6 trap dicarboxylate transporter dctm subunit KU6B_RS06785 ENOG41060I7 thioesterase Superfamily protein KU6B_RS06825 ENOG4107HP6 Transcriptional regulator KU6B_RS06840 ENOG4105MSY salicylate hydroxylase KU6B_RS06860 ENOG4108I05 Binding-protein-dependent transport systems, inner membrane component KU6B_RS06875 ENOG4108MXF Alpha Beta Hydrolase KU6B_RS06885 ENOG4105CHR reductase KU6B_RS06895 ENOG4108Q27 Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate (By similarity) KU6B_RS06900 ENOG4105C26 Dehydrogenase KU6B_RS06910 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) KU6B_RS06920 ENOG4108K2P TRANSCRIPTIONal KU6B_RS06965 ENOG4105RD8 TRAP dicarboxylate transporter KU6B_RS06970 ENOG4105CNQ glycine cleavage T protein, aminomethyl transferase KU6B_RS06980 ENOG4105CM2 brancheD-chain amino acid aminotransferase KU6B_RS06985 ENOG4108JCI Transcriptional regulator KU6B_RS06990 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) KU6B_RS07000 ENOG4105CFF transcriptional regulator KU6B_RS07010 ENOG4105CI0 Citrate lyase KU6B_RS07015 ENOG4105CMV Succinyl-CoA synthetase subunit beta KU6B_RS07020 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha KU6B_RS07025 ENOG4108M9J MaoC like domain protein KU6B_RS07030 ENOG4105IYB L-carnitine dehydratase bile acid-inducible protein F KU6B_RS07040 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) KU6B_RS07045 ENOG4105CHU acetyl-coa acetyltransferase KU6B_RS07050 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit KU6B_RS07055 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit KU6B_RS07060 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit KU6B_RS07065 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit KU6B_RS07070 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) KU6B_RS07080 ENOG4105DXM phenylacetic acid degradation protein KU6B_RS07085 ENOG4105V9J phenylacetic acid degradation operon negative regulatory protein KU6B_RS07100 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) KU6B_RS07105 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) KU6B_RS07120 ENOG4107QP6 Xylose isomerase domain protein TIM barrel KU6B_RS07125 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) KU6B_RS07130 ENOG4105C2J ABC transporter KU6B_RS07135 ENOG4105CNN ABC, transporter KU6B_RS07140 ENOG4105CNN ABC, transporter KU6B_RS07170 ENOG4105CSV Glutaminase KU6B_RS07180 ENOG4105DEF Extracellular solute-binding protein, family 5 KU6B_RS07195 ENOG4108JQ7 (ABC) transporter KU6B_RS07200 ENOG4108YXU transcriptional regulator AsnC family KU6B_RS07245 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) KU6B_RS07250 ENOG4105EUX methane phenol toluene hydroxylase KU6B_RS07265 ENOG4108ZFP monooxygenase component MmoB DmpM KU6B_RS07280 ENOG4108MFQ Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) KU6B_RS07290 ENOG4108UYE Lactoylglutathione lyase KU6B_RS07305 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) KU6B_RS07315 ENOG4105E6M Sulphatase-modifying factor protein KU6B_RS07325 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) KU6B_RS07345 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) KU6B_RS07360 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) KU6B_RS07370 ENOG4105BZ1 (ABC) transporter KU6B_RS07380 ENOG4105C5R Aminotransferase KU6B_RS07385 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) KU6B_RS07400 ENOG4105CIH Imidazole acetol-phosphate transaminase KU6B_RS07445 ENOG4105D6E homoserine dehydrogenase KU6B_RS07565 ENOG4105EF7 Transcriptional regulator KU6B_RS07590 ENOG4105DDW LysR family Transcriptional regulator KU6B_RS07605 ENOG4105CBG Sulfatase KU6B_RS07660 ENOG4108XM1 transcriptional regulator AsnC family KU6B_RS07675 ENOG4105E1J oxidoreductase KU6B_RS07705 ENOG4105D38 putrescine abc transporter KU6B_RS07710 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) KU6B_RS07735 ENOG4105E9Z Nad-dependent epimerase dehydratase KU6B_RS07765 ENOG4105D64 Mechanosensitive ion channel KU6B_RS07800 ENOG4105DDR sarcosine oxidase (Beta subunit) KU6B_RS07810 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) KU6B_RS07820 ENOG4105CFU surface antigen KU6B_RS07830 ENOG4108RW8 Universal stress protein F KU6B_RS07840 ENOG4105H1G trap transporter solute receptor taxi family KU6B_RS07855 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) KU6B_RS07860 ENOG41082A2 Alpha beta hydrolase KU6B_RS07865 ENOG4107SV1 subunit D KU6B_RS07870 ENOG4105EET magnesium chelatase KU6B_RS07875 ENOG4108ZIP spheroidene monooxygenase KU6B_RS07880 ENOG4105EWK phytoene KU6B_RS07890 ENOG4105KAV tspo and mbr like protein KU6B_RS07895 ENOG4108PZJ hydroxyneurosporene synthase KU6B_RS07900 ENOG4107VFM Dehydrogenase KU6B_RS07905 ENOG4105CTB Polyprenyl synthetase KU6B_RS07910 ENOG4107EPK O-methyltransferase, family 2 KU6B_RS07920 ENOG4105DSM The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components the iron protein and the molybdenum-iron protein (By similarity) KU6B_RS07925 ENOG41060GA Chlorophyllide reductase subunit Y KU6B_RS07930 ENOG4105ETK chlorophyllide reductase subunit Z KU6B_RS07945 ENOG41084RU Antenna complexes are light-harvesting systems, which transfer the excitation energy to the reaction centers KU6B_RS07955 ENOG4107R94 photosynthetic reaction center, M subunit KU6B_RS07960 ENOG4105J6N PhotosynthetiC reaction center cytochrome c subunit KU6B_RS07965 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) KU6B_RS07975 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) KU6B_RS07980 ENOG4108TF2 Photosynthetic complex assembly protein 2 KU6B_RS07985 ENOG4105FBB Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME) (By similarity) KU6B_RS08005 ENOG4108S36 Photosynthetic reaction center KU6B_RS08010 ENOG4105XCI PucC protein KU6B_RS08015 ENOG4108MIC Mg-protoporphyrin IX methyl transferase KU6B_RS08020 ENOG4105DSM The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components the iron protein and the molybdenum-iron protein (By similarity) KU6B_RS08035 ENOG4105C78 Uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent (By similarity) KU6B_RS08040 ENOG4108VJI 2-vinyl bacteriochlorophyllide hydratase KU6B_RS08050 ENOG4105D4D transcriptional regulator KU6B_RS08075 ENOG4105C2J ABC transporter KU6B_RS08080 ENOG41062B0 ABC transporter, permease KU6B_RS08105 ENOG4105C5I Dehydrogenase KU6B_RS08110 ENOG4108JQ6 ABC transporter KU6B_RS08115 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component KU6B_RS08125 ENOG4105DEF Extracellular solute-binding protein, family 5 KU6B_RS08130 ENOG4106NZI LysR family Transcriptional regulator KU6B_RS08150 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) KU6B_RS08155 ENOG4105C0A alcohol dehydrogenase KU6B_RS08165 ENOG4107S2N Type III effector Hrp-dependent KU6B_RS08170 ENOG4105CHR reductase KU6B_RS08180 ENOG4105E9F Enoyl-CoA hydratase KU6B_RS08190 ENOG4105C5I Dehydrogenase KU6B_RS08225 ENOG4105EXW epimerase dehydratase KU6B_RS08230 ENOG4107SS6 2-dehydro-3-deoxygluconokinase KU6B_RS08235 ENOG4105CQB FAD linked oxidase domain protein KU6B_RS08245 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase KU6B_RS08250 ENOG4105D4X repressor KU6B_RS08275 ENOG4105H9W Short-chain dehydrogenase reductase Sdr KU6B_RS08280 ENOG4108SXK Transporter Drug Metabolite Exporter family KU6B_RS08285 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr KU6B_RS08295 ENOG4105CTX dehydratase KU6B_RS08300 ENOG4105EV8 ectoine hydroxylase KU6B_RS08305 ENOG4105CG6 trap dicarboxylate transporter dctm subunit KU6B_RS08315 ENOG4105GQU Trap dicarboxylate transporter, dctp subunit KU6B_RS08345 ENOG4105C1G acyl-Coa dehydrogenase KU6B_RS08355 ENOG4105DE9 3-keto-5-aminohexanoate cleavage enzyme KU6B_RS08370 ENOG4105SYT Methylenetetrahydrofolate reductase KU6B_RS08375 ENOG4105DZ2 Transcriptional regulator KU6B_RS08390 ENOG4105KUZ arsenate reductase KU6B_RS08410 ENOG4105E18 UPF0276 protein KU6B_RS08420 ENOG4105C22 threonyL-tRNA synthetase KU6B_RS08470 ENOG4105W0E 50S ribosomal protein L33 KU6B_RS08475 ENOG4105KEG ribosomal-protein-alanine acetyltransferase KU6B_RS08485 ENOG4105HFZ Membrane KU6B_RS08505 ENOG4105EEF Alkane 1-monooxygenase KU6B_RS08515 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) KU6B_RS08535 ENOG4105EW9 transcriptional regulator AsnC family KU6B_RS08540 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) KU6B_RS08555 ENOG4105K4P CoA-binding domain protein KU6B_RS08570 ENOG4105KPZ phosphoribosyl-atp pyrophosphatase KU6B_RS08580 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) KU6B_RS08605 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) KU6B_RS08610 ENOG4105ECC imidazole-glycerol-phosphate dehydratase KU6B_RS08640 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase KU6B_RS08650 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) KU6B_RS08665 ENOG4105C4R Atp-dependent dna helicase KU6B_RS08685 ENOG4105MPN Membrane KU6B_RS08730 ENOG41080G2 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) KU6B_RS08735 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) KU6B_RS08750 ENOG4105CFF transcriptional regulator KU6B_RS08755 ENOG4105C2C drug resistance transporter, Bcr CflA KU6B_RS08835 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) KU6B_RS08855 ENOG4107W75 Flagellin KU6B_RS08880 ENOG4105C02 permease KU6B_RS08890 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) KU6B_RS08900 ENOG4108A04 Beta-lactamase KU6B_RS08910 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) KU6B_RS08915 ENOG4105EEI dihydropteroate synthase KU6B_RS08930 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) KU6B_RS08935 ENOG4105C38 Glycyl-tRNA synthetase beta subunit KU6B_RS09015 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase KU6B_RS09025 ENOG4108ZRZ Transcriptional regulator (AsnC family) KU6B_RS09055 ENOG4105DRR Transcriptional regulator, GntR family KU6B_RS09065 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain KU6B_RS09070 ENOG4105KTH gatB Yqey KU6B_RS09100 ENOG4105BZ9 Cytochrome C oxidase, subunit I KU6B_RS09115 ENOG4105K5X acetyltransferase KU6B_RS09120 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) KU6B_RS09160 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F KU6B_RS09195 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase KU6B_RS09220 ENOG4105CG6 trap dicarboxylate transporter dctm subunit KU6B_RS09255 ENOG4105CHU acetyl-coa acetyltransferase KU6B_RS09275 ENOG4105DFW ABC transporter KU6B_RS09285 ENOG4108HWW ABC transporter KU6B_RS09315 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) KU6B_RS09335 ENOG4108UQY Iron-storage protein KU6B_RS09370 ENOG4105BZU Histidine kinase KU6B_RS09385 ENOG4105D1F ATP-binding protein KU6B_RS09425 ENOG4108JB9 formate dehydrogenase KU6B_RS09430 ENOG4105QAX Iron-sulfur KU6B_RS09445 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family KU6B_RS09465 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family KU6B_RS09485 ENOG4105E0X reductase KU6B_RS09510 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) KU6B_RS09535 ENOG4105CD8 aminopeptidase N KU6B_RS09540 ENOG4105CVP deoxyribo-dipyrimidine photolyase KU6B_RS09570 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) KU6B_RS09585 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) KU6B_RS09590 ENOG4105CVW peptidase s1 and s6 chymotrypsin hap KU6B_RS09595 ENOG4105VIE preprotein translocase, subunit YajC KU6B_RS09600 ENOG4107RSV Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) KU6B_RS09605 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) KU6B_RS09615 ENOG4108UIV Protein of unknown function (DUF498/DUF598) KU6B_RS09620 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) KU6B_RS09625 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) KU6B_RS09630 ENOG41060IM Heme exporter protein KU6B_RS09640 ENOG4107QX9 Thiol disulfide interChange protein KU6B_RS09690 ENOG4107QM5 aconitate hydratase KU6B_RS09720 ENOG4105C83 adenylosuccinate lyase KU6B_RS09735 ENOG4105CUC YeeE YedE family protein KU6B_RS09760 ENOG4108JQ6 ABC transporter KU6B_RS09765 ENOG4105CWC Acetylornithine deacetylase KU6B_RS09770 ENOG4105MWK D-amino acid dehydrogenase, small subunit KU6B_RS09775 ENOG4105CH2 amidohydrolase KU6B_RS09780 ENOG4105CH2 amidohydrolase KU6B_RS09790 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) KU6B_RS09805 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) KU6B_RS09810 ENOG4105HHA aminodeoxychorismate lyase KU6B_RS09830 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) KU6B_RS09885 ENOG4105C0H protease KU6B_RS09915 ENOG4105ED9 Protein of unknown function (DUF455) KU6B_RS09920 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen KU6B_RS09950 ENOG4107QN2 dihydrolipoyl dehydrogenase KU6B_RS09965 ENOG4105DHZ alpha beta KU6B_RS09970 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family KU6B_RS09990 ENOG4105C3K feS assembly ATPase SufC KU6B_RS09995 ENOG4105JRK feS assembly protein SufD KU6B_RS10010 ENOG4105C9B Cysteine desulfurase KU6B_RS10015 ENOG4107T2S C-20 methyltransferase BchU KU6B_RS10045 ENOG4107UNZ domain protein KU6B_RS10070 ENOG4105VFQ Histone family protein nucleoid-structuring protein H-NS KU6B_RS10085 ENOG4105W5Q DNA repair protein (RadC KU6B_RS10195 ENOG4105E4C Lytic transglycosylase catalytic KU6B_RS10305 ENOG4107RSM transcriptional regulator KU6B_RS10310 ENOG4105VN1 Heat shock protein KU6B_RS10315 ENOG4105VN1 Heat shock protein KU6B_RS10325 ENOG4105D0M Protease HtpX homolog KU6B_RS10335 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit KU6B_RS10350 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) KU6B_RS10365 ENOG4108ZNX Heat shock protein KU6B_RS10410 ENOG4105N14 lysine exporter protein LysE YggA KU6B_RS10425 ENOG4105N14 lysine exporter protein LysE YggA KU6B_RS10440 ENOG4105CM2 brancheD-chain amino acid aminotransferase KU6B_RS10445 ENOG4105ETT transcriptional Regulator, LysR family KU6B_RS10460 ENOG4105VZ8 Transcriptional regulator KU6B_RS10490 ENOG4105JAB phenazine biosynthesis protein, phzf family KU6B_RS10495 ENOG4108V1U phospholipid-binding protein KU6B_RS10500 ENOG4105DJB Major Facilitator Superfamily KU6B_RS10550 ENOG4108RPX mosc domain containing protein KU6B_RS10555 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain KU6B_RS10565 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) KU6B_RS10570 ENOG4105VKD bioY protein KU6B_RS10595 ENOG4105EQ0 Major Facilitator superfamily KU6B_RS10600 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) KU6B_RS10610 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) KU6B_RS10625 ENOG4105EMY transcriptional regulator KU6B_RS10635 ENOG4105E3W Two component transcriptional regulator (Winged helix family KU6B_RS10640 ENOG4105E0F Histidine kinase KU6B_RS10645 ENOG4105K64 Glycosyl transferase, family 2 KU6B_RS10655 ENOG4105BZ1 (ABC) transporter KU6B_RS10660 ENOG4105CBG Sulfatase KU6B_RS10670 ENOG4106IEQ KU6B_RS10675 ENOG4107S7U Sulfide dehydrogenase KU6B_RS10695 ENOG4105C4M (Ubiquinol oxidase) subunit I KU6B_RS10700 ENOG4108JJ8 (ABC) transporter KU6B_RS10710 ENOG4105KPV Transcriptional regulator KU6B_RS10725 ENOG4108JPW Aminotransferase KU6B_RS10730 ENOG4108Z6K Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity) KU6B_RS10735 ENOG4105CZK Aspartate kinase KU6B_RS10755 ENOG4105WH1 Two component transcriptional regulator luxr family KU6B_RS10765 ENOG4105BZU Histidine kinase KU6B_RS10775 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation KU6B_RS10785 ENOG4105FE5 Homospermidine synthase KU6B_RS10800 ENOG4105K9Q Binds to the 23S rRNA (By similarity) KU6B_RS10805 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) KU6B_RS10810 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) KU6B_RS10820 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase KU6B_RS10840 ENOG4105DXN mazG family KU6B_RS10845 ENOG4105CH2 amidohydrolase KU6B_RS10850 ENOG4105CH2 amidohydrolase KU6B_RS10855 ENOG4105CYW agmatinase KU6B_RS10865 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) KU6B_RS10870 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) KU6B_RS10880 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) KU6B_RS10885 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) KU6B_RS10895 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) KU6B_RS10910 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) KU6B_RS10920 ENOG4108WIW Aspartyl protease KU6B_RS10925 ENOG41081FY multiple antibiotic resistance (MarC)-related KU6B_RS10935 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) KU6B_RS10945 ENOG4108JZP Catalyzes the decarboxylation of oxaloacetate into pyruvate. Seems to play a role in maintaining cellular concentrations of bicarbonate and pyruvate (By similarity) KU6B_RS10950 ENOG4105CHM Aminotransferase KU6B_RS11040 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters KU6B_RS11045 ENOG4105D7W serine acetyltransferase KU6B_RS11050 ENOG4105C7S Dehydrogenase KU6B_RS11060 ENOG4105CPP Dehydrogenase, E1 component KU6B_RS11070 ENOG4108JYK Dehydrogenase KU6B_RS11075 ENOG4106ABQ septum formation initiator KU6B_RS11090 ENOG4105C5Q Transcriptional regulator KU6B_RS11145 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) KU6B_RS11155 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) KU6B_RS11175 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) KU6B_RS11180 ENOG4107S75 HAD-superfamily hydrolase subfamily IA variant 3 KU6B_RS11210 ENOG4105C1G acyl-Coa dehydrogenase KU6B_RS11230 ENOG4107QX3 carboxylase KU6B_RS11250 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase KU6B_RS11260 ENOG4105E39 Enoyl-CoA hydratase KU6B_RS11275 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain KU6B_RS11280 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) KU6B_RS11285 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain KU6B_RS11295 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) KU6B_RS11325 ENOG41080PD NADH ubiquinone oxidoreductase 41 kD complex I subunit KU6B_RS11335 ENOG4107QIZ NADH dehydrogenase KU6B_RS11400 ENOG4108048 decarboxylase KU6B_RS11405 ENOG4105DF2 NADH dehydrogenase subunit j KU6B_RS11415 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) KU6B_RS11420 ENOG4105D65 subunit l KU6B_RS11425 ENOG4105C8S subunit m KU6B_RS11430 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) KU6B_RS11435 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase KU6B_RS11440 ENOG4107QNB Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) KU6B_RS11455 ENOG4105C1J atp-dependent rna helicase KU6B_RS11500 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) KU6B_RS11520 ENOG4108Z4X TRANSCRIPTIONal KU6B_RS11590 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit KU6B_RS11600 ENOG4105MSY salicylate hydroxylase KU6B_RS11605 ENOG4107XAN XdhC and CoxI family KU6B_RS11620 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) KU6B_RS11630 ENOG4105CXN decarboxylase KU6B_RS11635 ENOG4105DP0 ferredoxin-NADP reductase KU6B_RS11645 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) KU6B_RS11650 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) KU6B_RS11660 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) KU6B_RS11665 ENOG4108XM1 transcriptional regulator AsnC family KU6B_RS11675 ENOG4105CQZ Histidine kinase KU6B_RS11680 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family KU6B_RS11685 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit KU6B_RS11690 ENOG410835K Tripartite ATP-Independent Periplasmic transporter DctQ KU6B_RS11695 ENOG4105CG6 trap dicarboxylate transporter dctm subunit KU6B_RS11700 ENOG4105CP7 Triose-phosphate isomerase KU6B_RS11725 ENOG4105CZQ inner membrane transport protein YdhC KU6B_RS11745 ENOG4105VG1 fes assembly suf system protein KU6B_RS11750 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) KU6B_RS11755 ENOG4105EUB pirin domain protein KU6B_RS11785 ENOG4108E1C hydrolase KU6B_RS11790 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) KU6B_RS11795 ENOG4105X96 Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Activated D-alanyl-Dcp donates its D-alanyl substituent to membrane-associated LTA (By similarity) KU6B_RS11805 ENOG4105C5H ABC transporter KU6B_RS11835 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F KU6B_RS11840 ENOG4105CYW agmatinase KU6B_RS11860 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B KU6B_RS11875 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) KU6B_RS11880 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) KU6B_RS11900 ENOG4105CI3 gtp-binding protein typa KU6B_RS11910 ENOG410814C multidrug resistance protein KU6B_RS11930 ENOG4105C8Q Methyl-accepting chemotaxis KU6B_RS11940 ENOG4105NPQ Pfam:DUF403 KU6B_RS11990 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) KU6B_RS11995 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) KU6B_RS12015 ENOG4105JSC dimethylmenaquinone methyltransferase KU6B_RS12025 ENOG4105GAK amidohydrolase 2 KU6B_RS12060 ENOG4105U1N riboflavin KU6B_RS12085 ENOG4108EMS branched-chain alpha-keto acid dehydrogenase subunit E2 KU6B_RS12125 ENOG4105H1N peptidase, M24 KU6B_RS12130 ENOG4105CHR reductase KU6B_RS12140 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator KU6B_RS12145 ENOG4105CHR reductase KU6B_RS12150 ENOG4105CNN ABC, transporter KU6B_RS12155 ENOG4105CNN ABC, transporter KU6B_RS12160 ENOG4105C2J ABC transporter KU6B_RS12165 ENOG4107RDJ Sulfotransferase KU6B_RS12195 ENOG4105DKK Benzoate KU6B_RS12210 ENOG4108ESU Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity) KU6B_RS12215 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) KU6B_RS12225 ENOG4105JQN Transcriptional regulator KU6B_RS12230 ENOG4105EUB pirin domain protein KU6B_RS12235 ENOG4105CHJ isochorismatase hydrolase KU6B_RS12255 ENOG4108IGT Dipeptidase KU6B_RS12290 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) KU6B_RS12295 ENOG4105K46 50S ribosomal protein l27 KU6B_RS12305 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control KU6B_RS12310 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) KU6B_RS12315 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) KU6B_RS12340 ENOG4106HMZ Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) KU6B_RS12365 ENOG4107TQK Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity) KU6B_RS12390 ENOG4105P0T Usg family KU6B_RS12400 ENOG4105D52 delta-aminolevulinic acid dehydratase KU6B_RS12455 ENOG4105DAE Methylenetetrahydrofolate reductase KU6B_RS12470 ENOG4105C9X ppx gppa phosphatase KU6B_RS12475 ENOG4105KCV RNA signal recognition particle 4.5S RNA KU6B_RS12500 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) KU6B_RS12540 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) KU6B_RS12550 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) KU6B_RS12575 ENOG4108KNB n-acetylmuramoyl-l-alanine amidase KU6B_RS12585 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) KU6B_RS12615 ENOG4108ZP8 Acetolactate synthase small subunit KU6B_RS12620 ENOG4105BZU Histidine kinase KU6B_RS12650 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit KU6B_RS12670 ENOG4105DWA May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate KU6B_RS12690 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) KU6B_RS12700 ENOG4108UHU Aldolase KU6B_RS12705 ENOG4105C01 Dihydroxy-acid dehydratase KU6B_RS12720 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) KU6B_RS12750 ENOG4105CAH Chromate KU6B_RS12780 ENOG4108I05 Binding-protein-dependent transport systems, inner membrane component KU6B_RS12795 ENOG4108X0B nad(p)h dehydrogenase (quinone) KU6B_RS12800 ENOG4108X0B nad(p)h dehydrogenase (quinone) KU6B_RS12830 ENOG4105CNN ABC, transporter KU6B_RS12840 ENOG4105ETE Transcriptional regulator (LacI family KU6B_RS12855 ENOG4105C8Q Methyl-accepting chemotaxis KU6B_RS12860 ENOG4107SDU Methyl-accepting chemotaxis KU6B_RS12865 ENOG4105KVH Transcriptional regulator KU6B_RS12870 ENOG4105ECR NmrA family KU6B_RS12875 ENOG4105HEI LysR family (Transcriptional regulator KU6B_RS12890 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b KU6B_RS12895 ENOG4105CHF Glutathione S-transferase KU6B_RS12905 ENOG4105C0D helicase KU6B_RS12930 ENOG4105C0D helicase KU6B_RS12950 ENOG4107QKA exodeoxyribonuclease V beta KU6B_RS12965 ENOG4107VRP DNA repair exonuclease KU6B_RS13060 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) KU6B_RS13065 ENOG4105E0F Histidine kinase KU6B_RS13080 ENOG4105E43 Extracellular solute-binding protein, family 5 KU6B_RS13100 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) KU6B_RS13110 ENOG4105ETT transcriptional Regulator, LysR family KU6B_RS13115 ENOG4105C1G acyl-Coa dehydrogenase KU6B_RS13125 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) KU6B_RS13135 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) KU6B_RS13140 ENOG4105CE9 30S ribosomal protein S2 KU6B_RS13150 ENOG4105CK6 Two component transcriptional regulator (Winged helix family KU6B_RS13155 ENOG4108UTW Plays a role in the regulation of phosphate uptake KU6B_RS13160 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) KU6B_RS13180 ENOG4105BZU Histidine kinase KU6B_RS13185 ENOG4105C28 cystathionine KU6B_RS13195 ENOG4108Z0R Transferase KU6B_RS13200 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) KU6B_RS13205 ENOG4105DSJ YicC domain protein KU6B_RS13215 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase KU6B_RS13220 ENOG4105ECQ AraC Family Transcriptional Regulator KU6B_RS13245 ENOG4105C0Z ABC transporter KU6B_RS13250 ENOG4108IV0 ABC, transporter KU6B_RS13270 ENOG4105C32 Amino acid ABC transporter (Permease) KU6B_RS13300 ENOG4107SVH Potassium channel protein KU6B_RS13305 ENOG4105C2C drug resistance transporter, Bcr CflA KU6B_RS13335 ENOG4107RTZ reductase KU6B_RS13355 ENOG4105VEQ Cold shock protein KU6B_RS13360 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) KU6B_RS13365 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH KU6B_RS13375 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) KU6B_RS13395 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) KU6B_RS13405 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) KU6B_RS13415 ENOG4108V3E phosphoribosylglycinamide formyltransferase KU6B_RS13420 ENOG4105CXB phosphoribosylaminoimidazole synthetase KU6B_RS13440 ENOG4105D7A ATP-binding protein KU6B_RS13450 ENOG4105CKW Inner membrane protein yedI KU6B_RS13460 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase KU6B_RS13480 ENOG4105CQZ Histidine kinase KU6B_RS13485 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I KU6B_RS13495 ENOG4105VR9 phosphoribosylformylglycinamidine synthase KU6B_RS13525 ENOG4107QPR SAICAR synthetase KU6B_RS13560 ENOG4105CVG Homoserine O-transsuccinylase KU6B_RS13570 ENOG4105CSR polyphosphate kinase 2 KU6B_RS13575 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) KU6B_RS13590 ENOG4108UJD 30S ribosomal protein S9 KU6B_RS13595 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) KU6B_RS13610 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) KU6B_RS13615 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) KU6B_RS13630 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) KU6B_RS13635 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) KU6B_RS13640 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) KU6B_RS13645 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase KU6B_RS13655 ENOG4105CB5 ATP-dependent DNA helicase recG KU6B_RS13660 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) KU6B_RS13675 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) KU6B_RS13700 ENOG41082GS 50S ribosomal protein L32 KU6B_RS13705 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) KU6B_RS13710 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) KU6B_RS13715 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) KU6B_RS13720 ENOG4105WJX transcriptional regulator MERR family KU6B_RS13735 ENOG4105DHP deoxycytidine triphosphate deaminase KU6B_RS13745 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) KU6B_RS13750 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) KU6B_RS13765 ENOG4105C75 arginyL-tRNA synthetase KU6B_RS13770 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) KU6B_RS13775 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein KU6B_RS13790 ENOG4108YX9 iron--sulfur cluster insertion protein erpA KU6B_RS13825 ENOG4105M2J Glutaredoxin KU6B_RS13845 ENOG4105CV1 Transketolase (EC 2.2.1.1) KU6B_RS13850 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) KU6B_RS13860 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) KU6B_RS13865 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) KU6B_RS13875 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane KU6B_RS13880 ENOG4105DZP Membrane-associated zinc metalloprotease KU6B_RS13900 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) KU6B_RS13925 ENOG4105DEF Extracellular solute-binding protein, family 5 KU6B_RS13950 ENOG4105E4C Lytic transglycosylase catalytic KU6B_RS13955 ENOG4108UUM single-stranded DNA-binding protein KU6B_RS13970 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) KU6B_RS13985 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) KU6B_RS13990 ENOG4108JU6 CBS domain protein KU6B_RS14060 ENOG4105D7T ABC transporter KU6B_RS14130 ENOG4105DZC cytosine deaminase KU6B_RS14135 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) KU6B_RS14140 ENOG4105D38 putrescine abc transporter KU6B_RS14145 ENOG4105F38 ABC transporter, permease KU6B_RS14165 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) KU6B_RS14170 ENOG4108ZJ4 polysaccharide deacetylase KU6B_RS14195 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) KU6B_RS14235 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase KU6B_RS14240 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) KU6B_RS14245 ENOG4105DWF phosphomethylpyrimidine kinase KU6B_RS14250 ENOG4105ETU transcriptional activator (TenA KU6B_RS14290 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase KU6B_RS14305 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) KU6B_RS14320 ENOG4105C26 Dehydrogenase KU6B_RS14330 ENOG4106KXD ATP-dependent carboxylate-amine ligase (By similarity) KU6B_RS14340 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease KU6B_RS14345 ENOG4107T8Q Glycosyl transferase (Group 1 KU6B_RS14350 ENOG4105C1G acyl-Coa dehydrogenase KU6B_RS14370 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) KU6B_RS14385 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase KU6B_RS14390 ENOG4107UX3 phosphatidylethanolamine N-methyltransferase KU6B_RS14400 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) KU6B_RS14405 ENOG4105CG3 alpha amylase, catalytic region KU6B_RS14415 ENOG4105S9S Binding-protein-dependent transport systems, inner membrane component KU6B_RS14425 ENOG4105FKQ transcriptional regulator KU6B_RS14435 ENOG4105CHC glucokinase (EC 2.7.1.2) KU6B_RS14445 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) KU6B_RS14450 ENOG4105BZU Histidine kinase KU6B_RS14455 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) KU6B_RS14460 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase KU6B_RS14470 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) KU6B_RS14485 ENOG4105DND Transcriptional regulator KU6B_RS14490 ENOG4107QIK phosphoribosylformylglycinamidine synthase KU6B_RS14495 ENOG4105D0M Protease HtpX homolog KU6B_RS14500 ENOG4105F1N DNA alkylation repair KU6B_RS14505 ENOG4105CHR reductase KU6B_RS14535 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) KU6B_RS14560 ENOG4105KCK Peptidoglycan-associated lipoprotein KU6B_RS14620 ENOG4105EKE dihydroorotase KU6B_RS14625 ENOG4108YAB Invasion protein KU6B_RS14635 ENOG4107SW0 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) KU6B_RS14645 ENOG4108UHF Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) KU6B_RS14650 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) KU6B_RS14655 ENOG4105CY3 ABC transporter, permease KU6B_RS14680 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase KU6B_RS14700 ENOG4105PDP Short chain dehydrogenase KU6B_RS14705 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) KU6B_RS14710 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) KU6B_RS14720 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) KU6B_RS14735 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) KU6B_RS14740 ENOG41081BE Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) KU6B_RS14745 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) KU6B_RS14760 ENOG4105WYW fructose-bisphosphate aldolase KU6B_RS14775 ENOG4107QIV Cytochrome c biogenesis protein KU6B_RS14780 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) KU6B_RS14790 ENOG4105C03 ribonuclease KU6B_RS14790 ENOG4105C03 ribonuclease KU6B_RS14800 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase KU6B_RS14820 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) KU6B_RS14825 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) KU6B_RS14835 ENOG4105C1A potassium transporter peripheral membrane KU6B_RS14845 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family KU6B_RS14850 ENOG4105ES5 Histidine kinase KU6B_RS14860 ENOG4105CUX Signal transduction histidine kinase KU6B_RS14865 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) KU6B_RS14870 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) KU6B_RS14875 ENOG4108ZAI phosphatidylglycerophosphatase a KU6B_RS14880 ENOG4107TH8 cina domain protein KU6B_RS14885 ENOG4105BZU Histidine kinase KU6B_RS14900 ENOG4108Z1B Cyclase dehydrase KU6B_RS14905 ENOG4108UGV hypoxanthine phosphoribosyltransferase KU6B_RS14930 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) KU6B_RS14945 ENOG4105F5V trimethylamine methyltransferase KU6B_RS14970 ENOG4108M3R transcriptional activator CadC KU6B_RS14975 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) KU6B_RS15015 ENOG4108Q52 Methyltransferase cognate corrinoid protein KU6B_RS15025 ENOG4105K8R UPF0145 protein KU6B_RS15045 ENOG4105DDQ anthranilate synthase KU6B_RS15055 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) KU6B_RS15060 ENOG4105DK0 Indole-3-glycerol phosphate synthase KU6B_RS15065 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) KU6B_RS15070 ENOG4105CVM Molybdenum cofactor synthesis domain protein KU6B_RS15075 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) KU6B_RS15080 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 KU6B_RS15085 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) KU6B_RS15090 ENOG4105BZN citrate synthase KU6B_RS15095 ENOG4105CGU Enoyl-CoA hydratase KU6B_RS15110 ENOG4105KWW Biogenesis protein KU6B_RS15140 ENOG4107QP8 phosphohexose isomerase KU6B_RS15150 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase KU6B_RS15170 ENOG4105C2X Arabinose 5-phosphate isomerase KU6B_RS15175 ENOG4105CNG UPF0061 protein KU6B_RS15195 ENOG41090R7 Ferric uptake KU6B_RS15200 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) KU6B_RS15205 ENOG4105EGS Mechanosensitive ion channel KU6B_RS15215 ENOG41087AY ADP-Ribose pyrophosphatase KU6B_RS15225 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase KU6B_RS15235 ENOG4105CVP deoxyribo-dipyrimidine photolyase KU6B_RS15240 ENOG4105C9B Cysteine desulfurase KU6B_RS15245 ENOG4105C94 Transporter KU6B_RS15250 ENOG4108RW8 Universal stress protein F KU6B_RS15255 ENOG4105K59 histidine triad (HIT) protein KU6B_RS15260 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family KU6B_RS15295 ENOG4105KCK Peptidoglycan-associated lipoprotein KU6B_RS15310 ENOG4105X58 receptor KU6B_RS15315 ENOG4106QJH hemin transport protein KU6B_RS15320 ENOG4107R4I Periplasmic binding protein KU6B_RS15325 ENOG4105EHG Permease protein KU6B_RS15330 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) KU6B_RS15375 ENOG4105CDA abc transporter atp-binding protein KU6B_RS15390 ENOG4105E5Q amino acid AbC transporter KU6B_RS15420 ENOG4107RUE extracellular solute-binding protein family 1 KU6B_RS15430 ENOG4107V2S Transcriptional regulator KU6B_RS15440 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) KU6B_RS15450 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) KU6B_RS15455 ENOG4106J7G oxidoreductase KU6B_RS15470 ENOG4108NQD KU6B_RS15475 ENOG41089GP Oxidoreductase domain protein KU6B_RS15480 ENOG4105CNN ABC, transporter KU6B_RS15485 ENOG4105C2J ABC transporter KU6B_RS15495 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator KU6B_RS15500 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate KU6B_RS15515 ENOG4107QMS site-determining protein KU6B_RS15520 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) KU6B_RS15570 ENOG4105E0A ABC, transporter KU6B_RS15575 ENOG4105EHG Permease protein KU6B_RS15600 ENOG410827H Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S- specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX (By similarity) KU6B_RS15605 ENOG4108YZA Nitrogen regulatory protein pii KU6B_RS15610 ENOG4105C5F glutamine synthetase KU6B_RS15650 ENOG4105MWK D-amino acid dehydrogenase, small subunit KU6B_RS15670 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) KU6B_RS15675 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) KU6B_RS15710 ENOG4108IG5 Transcriptional regulator KU6B_RS15725 ENOG4108Z86 Glutamine amidotransferase KU6B_RS15735 ENOG4107QP3 malate synthase g KU6B_RS15755 ENOG4108URH decarboxylase KU6B_RS15760 ENOG4105FR1 rard protein KU6B_RS15775 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) KU6B_RS15790 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) KU6B_RS15805 ENOG4105DDR sarcosine oxidase (Beta subunit) KU6B_RS15815 ENOG4107ZJC Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) KU6B_RS15835 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) KU6B_RS15860 ENOG4107SET aldo keto reductase KU6B_RS15875 ENOG4107XQ1 cobalamin (vitamin B12) biosynthesis CbiM protein KU6B_RS15905 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) KU6B_RS15910 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) KU6B_RS15915 ENOG4105CIA precorrin-4 C(11)-methyltransferase KU6B_RS15930 ENOG4105QUC reductase KU6B_RS15985 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) KU6B_RS15995 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) KU6B_RS16015 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) KU6B_RS16020 ENOG4108UHF Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) KU6B_RS16045 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase KU6B_RS16055 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family KU6B_RS16065 ENOG4105CG6 trap dicarboxylate transporter dctm subunit KU6B_RS16085 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) KU6B_RS16095 ENOG4107QN1 sodium solute KU6B_RS16100 ENOG4105NAE bifunctional deaminase-reductase domain protein KU6B_RS16115 ENOG4108IRC dna polymerase iii KU6B_RS16125 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) KU6B_RS16145 ENOG4105CG6 trap dicarboxylate transporter dctm subunit KU6B_RS16190 ENOG4105C7B Threonine dehydratase KU6B_RS16195 ENOG4105C5R Aminotransferase KU6B_RS16200 ENOG4107HP6 Transcriptional regulator KU6B_RS16215 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) KU6B_RS16220 ENOG4105D9P serine threonine protein kinase KU6B_RS16230 ENOG4108ZF3 Phosphatase KU6B_RS16260 ENOG4107QSI ABC, transporter KU6B_RS16265 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component KU6B_RS16270 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component KU6B_RS16275 ENOG4105C3U ABC transporter KU6B_RS16280 ENOG4108JQ7 (ABC) transporter KU6B_RS16300 ENOG4105CTX dehydratase KU6B_RS16305 ENOG4105JSC dimethylmenaquinone methyltransferase KU6B_RS16310 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) KU6B_RS16325 ENOG4105CG6 trap dicarboxylate transporter dctm subunit KU6B_RS16380 ENOG4105DG4 malate L-lactate dehydrogenase KU6B_RS16385 ENOG4105CPQ Dehydrogenase KU6B_RS16390 ENOG4105CG6 trap dicarboxylate transporter dctm subunit KU6B_RS16400 ENOG4105GQU Trap dicarboxylate transporter, dctp subunit KU6B_RS16405 ENOG4107XBN GntR Family Transcriptional Regulator KU6B_RS16415 ENOG4105DEI Mannitol dehydrogenase KU6B_RS16420 ENOG4105CG6 trap dicarboxylate transporter dctm subunit KU6B_RS16430 ENOG4105CH5 extracellular solute-binding protein, family 7 KU6B_RS16460 ENOG4105D4B ABC, transporter KU6B_RS16465 ENOG4105C2J ABC transporter KU6B_RS16470 ENOG4105CNN ABC, transporter KU6B_RS16475 ENOG4105CNN ABC, transporter KU6B_RS16480 ENOG4105M10 Involved in the anomeric conversion of L-rhamnose (By similarity) KU6B_RS16490 ENOG4105BZU Histidine kinase KU6B_RS16530 ENOG4105K6H D-cysteine desulfhydrase KU6B_RS16560 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component KU6B_RS16565 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component KU6B_RS16570 ENOG4105DEF Extracellular solute-binding protein, family 5 KU6B_RS16575 ENOG4108WYP Transcriptional regulator KU6B_RS16595 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) KU6B_RS16605 ENOG4105CVM Molybdenum cofactor synthesis domain protein KU6B_RS16610 ENOG41077A9 carbonic anhydrase KU6B_RS16615 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) KU6B_RS16620 ENOG41076YT nitrate reductase, gamma subunit KU6B_RS16625 ENOG4105R3A Nitrate reductase KU6B_RS16630 ENOG4108IUE nitrate reductase beta subunit KU6B_RS16640 ENOG4105DQQ Major facilitator superfamily MFS_1 KU6B_RS16645 ENOG4107RNU major facilitator superfamily MFS_1 KU6B_RS16660 ENOG4105CEI nitrite reductase KU6B_RS16700 ENOG4105GMT ATPase associated with various cellular activities aaa_5 KU6B_RS16705 ENOG4105DSQ Nitric oxide reductase KU6B_RS16710 ENOG4108VKQ nitriC oxide reductase KU6B_RS16735 ENOG4105CNN ABC, transporter KU6B_RS16745 ENOG4105C2J ABC transporter KU6B_RS16750 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator KU6B_RS16755 ENOG4105BZU Histidine kinase KU6B_RS16835 ENOG4107YVC modification (methylase) KU6B_RS16845 ENOG41061ZR Transcriptional regulator KU6B_RS16850 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component KU6B_RS16890 ENOG4105CPP Dehydrogenase, E1 component KU6B_RS16920 ENOG4105CNV Aldolase KU6B_RS17005 ENOG4105DZ1 carboxypeptidase KU6B_RS17010 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) KU6B_RS17020 ENOG4105D1F ATP-binding protein KU6B_RS17030 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) KU6B_RS17035 ENOG4105C7K acetolactate synthase KU6B_RS17040 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) KU6B_RS17050 ENOG4105DZA Converts GTP to 7,8-dihydroneopterin triphosphate (By similarity) KU6B_RS17075 ENOG4108Z4U Ferredoxin KU6B_RS17080 ENOG4105VEJ Heat shock protein KU6B_RS17100 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) KU6B_RS17110 ENOG4107T0X DNA ligase KU6B_RS17135 ENOG4108IGT Dipeptidase KU6B_RS17140 ENOG4105KSC Transcriptional regulator, TraR DksA family KU6B_RS17160 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) KU6B_RS17165 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) KU6B_RS17170 ENOG4105CBG Sulfatase KU6B_RS17210 ENOG4108UK5 Transposase KU6B_RS17215 ENOG4105CDY transcriptional regulatory protein KU6B_RS17220 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) KU6B_RS17245 ENOG4107Z7P Ferredoxin KU6B_RS17250 ENOG4105C0B DNA polymerase III (alpha subunit) KU6B_RS17260 ENOG4105II7 pyrroline-5-carboxylate reductase KU6B_RS17285 ENOG4105EPW hflc protein KU6B_RS17290 ENOG4107QJR hflk protein KU6B_RS17305 ENOG4105CHH sulfate transporter KU6B_RS17320 ENOG4105E66 phosphoriboisomerase A KU6B_RS17380 ENOG4105DC7 peptidase M24 KU6B_RS17410 ENOG4105CQB FAD linked oxidase domain protein KU6B_RS17435 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) KU6B_RS17440 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane KU6B_RS17445 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) KU6B_RS17450 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) KU6B_RS17455 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) KU6B_RS17460 ENOG4108UFP Essential cell division protein (By similarity) KU6B_RS17465 ENOG4105CPF Cell wall formation (By similarity) KU6B_RS17470 ENOG4105D4A Cell wall formation (By similarity) KU6B_RS17490 ENOG4105DFU Cell wall formation (By similarity) KU6B_RS17495 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) KU6B_RS17510 ENOG4105CBX hi0933 family KU6B_RS17515 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) KU6B_RS17520 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) KU6B_RS17530 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) KU6B_RS17545 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) KU6B_RS17550 ENOG4107YZH Cell division protein mraZ KU6B_RS17640 ENOG4105EFV Major head subunit KU6B_RS17660 ENOG4108QUU Morphogenesis Protein KU6B_RS17670 ENOG4105QIB mu-like prophage Flumu protein gp29 KU6B_RS17885 ENOG4105F8V Hydrolase, tatD family KU6B_RS17890 ENOG4108H5C Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) KU6B_RS17900 ENOG4108SXK Transporter Drug Metabolite Exporter family KU6B_RS17910 ENOG4105CJW magnesium transporter KU6B_RS17925 ENOG4108KGA Nitrile hydratase KU6B_RS17940 ENOG4107EJC Preprotein translocase subunit SecG KU6B_RS17950 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) KU6B_RS17975 ENOG4105D6S protein involved in catabolism of external DNA KU6B_RS18000 ENOG4106PMH Extracellular solute-binding protein family 3 KU6B_RS18015 ENOG4105DMR ABC, transporter KU6B_RS18020 ENOG4105CFQ glutamine synthetase KU6B_RS18030 ENOG4105CFQ glutamine synthetase KU6B_RS18035 ENOG4105CJP fad dependent oxidoreductase KU6B_RS18040 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase KU6B_RS18050 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) KU6B_RS18055 ENOG4105C12 Phosphoribosylglycinamide synthetase KU6B_RS18065 ENOG4108SXK Transporter Drug Metabolite Exporter family KU6B_RS18085 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis KU6B_RS18100 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) KU6B_RS18105 ENOG4107TK4 histidinol-phosphate phosphatase KU6B_RS18110 ENOG4108WRK Transcriptional regulator KU6B_RS18165 ENOG4105ERH Fumarylacetoacetate hydrolase KU6B_RS18180 ENOG4107THI 3,4-dihydroxyphenylacetate 2,3-dioxygenase KU6B_RS18195 ENOG4108V8F Transcriptional regulator, MarR family KU6B_RS18205 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) KU6B_RS18215 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) KU6B_RS18250 ENOG4105CHR reductase KU6B_RS18295 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) KU6B_RS18315 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component KU6B_RS18320 ENOG4108IJ9 (ABC) transporter KU6B_RS18325 ENOG4108IJ9 (ABC) transporter KU6B_RS18335 ENOG4105E98 transcriptional regulator DeoR family KU6B_RS18355 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) KU6B_RS18395 ENOG4108ES0 acetoacetyl-CoA synthetase KU6B_RS18400 ENOG4108US0 Transcription regulator that can specifically activate or repress expression of target genes (By similarity) KU6B_RS18410 ENOG4108UKI Enoyl-CoA hydratase KU6B_RS18455 ENOG4107XZX Involved in the transcription termination process (By similarity) KU6B_RS18465 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) KU6B_RS18475 ENOG4105C2N RNA methyltransferase TrmH family group 3 KU6B_RS18495 ENOG4105FAV ABC, transporter KU6B_RS18500 ENOG4105FDK ABC transporter KU6B_RS18505 ENOG4105MYN Zinc uptake regulation protein KU6B_RS18515 ENOG4105E7W lamb ycsf family protein KU6B_RS18555 ENOG4105ES4 Nitrilase KU6B_RS18595 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) KU6B_RS18610 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase KU6B_RS18635 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) KU6B_RS18645 ENOG4107R16 Multicopper oxidase KU6B_RS18675 ENOG4108UW5 maltose o-acetyltransferase KU6B_RS18680 ENOG4105CHH sulfate transporter KU6B_RS18685 ENOG4107RHB Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity) KU6B_RS18695 ENOG410829K Lysine exporter protein (Lyse ygga) KU6B_RS18710 ENOG4105D1N poly(r)-hydroxyalkanoic acid synthase, class KU6B_RS18750 ENOG4105C79 DNA protecting protein DprA KU6B_RS18765 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) KU6B_RS18770 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) KU6B_RS18780 ENOG4105FT1 Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I (By similarity) KU6B_RS18785 ENOG4107QS1 Cytochrome C Oxidase, Subunit III KU6B_RS18795 ENOG4105D98 threonine synthase KU6B_RS18855 ENOG4105UYK outer membrane protein a KU6B_RS18930 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) KU6B_RS18935 ENOG4105C8Y Acetylornithine aminotransferase KU6B_RS18940 ENOG4105C26 Dehydrogenase KU6B_RS18945 ENOG4108RYR transcriptional regulator AsnC family KU6B_RS18960 ENOG4105ENR peptidase, M24 KU6B_RS18965 ENOG4105CWC Acetylornithine deacetylase KU6B_RS18970 ENOG4105CPQ Dehydrogenase KU6B_RS18975 ENOG4105F1G UPF0441 protein KU6B_RS19065 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) KU6B_RS19105 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate KU6B_RS19115 ENOG4105CG6 trap dicarboxylate transporter dctm subunit KU6B_RS19125 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit KU6B_RS19130 ENOG4105ETE Transcriptional regulator (LacI family KU6B_RS19150 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) KU6B_RS19170 ENOG4105DVW rieske (2Fe-2S) KU6B_RS19215 ENOG41073TP transcriptional regulator KU6B_RS19220 ENOG4105CP9 extracellular ligand-binding receptor KU6B_RS19230 ENOG4105DDR sarcosine oxidase (Beta subunit) KU6B_RS19235 ENOG4105WIU sarcosine oxidase delta subunit KU6B_RS19240 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) KU6B_RS19250 ENOG4105ECQ AraC Family Transcriptional Regulator KU6B_RS19265 ENOG4105E3J oxidoreductase KU6B_RS19275 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) KU6B_RS19290 ENOG4105EYU Glutamine amido-transferase KU6B_RS19295 ENOG4105M90 Glutamate synthase alpha subunit domain protein KU6B_RS19300 ENOG4105CBC glutamate synthase KU6B_RS19305 ENOG4105C5F glutamine synthetase KU6B_RS19310 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) KU6B_RS19315 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) KU6B_RS19320 ENOG4105C5I Dehydrogenase KU6B_RS19330 ENOG4105CMV Succinyl-CoA synthetase subunit beta KU6B_RS19340 ENOG4105WH1 Two component transcriptional regulator luxr family KU6B_RS19360 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) KU6B_RS19375 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) KU6B_RS19380 ENOG4105CKU formyltetrahydrofolate synthetase KU6B_RS19385 ENOG4108IEG Formate dehydrogenase Alpha subunit KU6B_RS19410 ENOG4105BZU Histidine kinase KU6B_RS19425 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) KU6B_RS19450 ENOG4105EMN RNA polymerase sigma factor KU6B_RS19470 ENOG4105EV9 Alpha Beta Hydrolase KU6B_RS19475 ENOG410811B TRANSCRIPTIONal KU6B_RS19515 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) KU6B_RS19545 ENOG4105KJF protein tyrosine phosphatase KU6B_RS19550 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) KU6B_RS19565 ENOG4105KDC 50s ribosomal protein l28 KU6B_RS19570 ENOG4105DJT lAO AO transport system ATPase KU6B_RS19580 ENOG4105DBV ornithine carbamoyltransferase KU6B_RS19585 ENOG4105C8Y Acetylornithine aminotransferase KU6B_RS19595 ENOG4108IGT Dipeptidase KU6B_RS19610 ENOG4105CH2 amidohydrolase KU6B_RS19630 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) KU6B_RS19635 ENOG4105CM6 amino acid regulated cytosolic protein KU6B_RS19645 ENOG4106K28 UPF0283 membrane protein KU6B_RS19665 ENOG41061H0 Monooxygenase KU6B_RS19675 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) KU6B_RS19690 ENOG4105WH1 Two component transcriptional regulator luxr family KU6B_RS19695 ENOG4105BZU Histidine kinase KU6B_RS19700 ENOG4105BZU Histidine kinase KU6B_RS19705 ENOG4105CEY Amp-dependent synthetase and ligase KU6B_RS19735 ENOG4105C32 Amino acid ABC transporter (Permease) KU6B_RS19740 ENOG4105CF8 branched-chain amino acid ABC transporter, permease KU6B_RS19745 ENOG4105C2J ABC transporter KU6B_RS19750 ENOG4108IV0 ABC, transporter KU6B_RS19770 ENOG4105BZ8 glutamate synthase KU6B_RS19775 ENOG4107SJI Dehydrogenase KU6B_RS19780 ENOG4108R86 Transcriptional regulator KU6B_RS19785 ENOG4105CE7 Amidase, hydantoinase carbamoylase family KU6B_RS19795 ENOG4105CD3 dihydroorotase KU6B_RS19815 ENOG4108I05 Binding-protein-dependent transport systems, inner membrane component KU6B_RS19840 ENOG4106YT9 Enoyl-CoA hydratase KU6B_RS19855 ENOG4105C1B dTDP-glucose 4-6-dehydratase KU6B_RS19860 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase KU6B_RS19865 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase KU6B_RS19870 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) KU6B_RS19880 ENOG4105G9V cytochrome C KU6B_RS19885 ENOG4105E43 Extracellular solute-binding protein, family 5 KU6B_RS19890 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component KU6B_RS19900 ENOG4108JQ5 ABC transporter KU6B_RS19905 ENOG4105D4P Coproporphyrinogen iii oxidase KU6B_RS19910 ENOG4105DS0 Transcriptional regulator, Crp Fnr family KU6B_RS19915 ENOG4105JAB phenazine biosynthesis protein, phzf family KU6B_RS19925 ENOG4105EUH cytochrome C oxidase, cbb3-type, subunit i KU6B_RS19940 ENOG4105D6P C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex (By similarity) KU6B_RS19945 ENOG410810E transcriptional regulator, lysR family KU6B_RS19950 ENOG4105C58 cytochrome c oxidase accessory protein ccog KU6B_RS19970 ENOG4108YXU transcriptional regulator AsnC family KU6B_RS19975 ENOG4105DCF alanine dehydrogenase KU6B_RS19985 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) KU6B_RS19990 ENOG4105CYM Glutathione S-transferase KU6B_RS19995 ENOG4108V0E nucleoside 2-deoxyribosyltransferase YtoQ KU6B_RS20035 ENOG4105CJN penicillin-binding protein KU6B_RS20040 ENOG4105CNI cell division protein FtsW KU6B_RS20045 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase KU6B_RS20050 ENOG4105DJV ribulose-phosphate 3-epimerase KU6B_RS20070 ENOG4105C1G acyl-Coa dehydrogenase KU6B_RS20085 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein KU6B_RS20125 ENOG4105VFQ Histone family protein nucleoid-structuring protein H-NS KU6B_RS20130 ENOG4105D3A purine nucleoside phosphorylase DeoD-type KU6B_RS20145 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) KU6B_RS20150 ENOG4105E33 succinate dehydrogenase KU6B_RS20165 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) KU6B_RS20175 ENOG410612Q succinate dehydrogenase (cytochrome b-556 subunit) KU6B_RS20185 ENOG4105DJG MaoC domain protein dehydratase KU6B_RS20215 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) KU6B_RS20220 ENOG4105CMV Succinyl-CoA synthetase subunit beta KU6B_RS20250 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 KU6B_RS20255 ENOG4105C7S Dehydrogenase KU6B_RS20275 ENOG4107QN2 dihydrolipoyl dehydrogenase KU6B_RS20325 ENOG4105CAK Cell division ATP-binding protein ftsE KU6B_RS20340 ENOG4108IY8 ABC, transporter KU6B_RS20350 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) KU6B_RS20365 ENOG4105K70 DNA-binding protein KU6B_RS20370 ENOG4105FYV Amp nucleosidase KU6B_RS20390 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) KU6B_RS20415 ENOG41090HR transcriptional regulator KU6B_RS20420 ENOG4105DPZ Two component transcriptional regulator (Winged helix family KU6B_RS20425 ENOG4105DGU Histone deacetylase KU6B_RS20430 ENOG41083BM Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) KU6B_RS20435 ENOG4105CTB Polyprenyl synthetase KU6B_RS20440 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) KU6B_RS20475 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) KU6B_RS20490 ENOG4105DEN Luciferase family KU6B_RS20495 ENOG4107QJN gtp cyclohydrolase ii KU6B_RS20500 ENOG4105CK6 Two component transcriptional regulator (Winged helix family KU6B_RS20505 ENOG4105K56 Transcriptional regulator KU6B_RS20510 ENOG4108ZHJ Organic hydroperoxide resistance protein KU6B_RS20525 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) KU6B_RS20530 ENOG4105EEQ Na H antiporter KU6B_RS20540 ENOG4105CKI cobalamin synthesis protein KU6B_RS20545 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) KU6B_RS20590 ENOG4105K63 Thioredoxin KU6B_RS20595 ENOG4105CGK Exodeoxyribonuclease III KU6B_RS20605 ENOG4105D3R alkyl hydroperoxide reductase KU6B_RS20620 ENOG4105D3G Pseudouridine synthase KU6B_RS20655 ENOG41082AN stage II sporulation protein KU6B_RS20665 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) KU6B_RS20685 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) KU6B_RS20690 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) KU6B_RS20710 ENOG4108Z7G MaoC domain protein dehydratase KU6B_RS20745 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) KU6B_RS20770 ENOG4105DC1 bifunctional purine biosynthesis protein purh KU6B_RS20795 ENOG4107ZGG Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) KU6B_RS20810 ENOG4105CMS peptidase U62, modulator of DNA gyrase KU6B_RS20825 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase KU6B_RS20830 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) KU6B_RS20845 ENOG4105YK5 50S ribosomal protein L36 KU6B_RS20870 ENOG4108IV0 ABC, transporter KU6B_RS20900 ENOG4105C32 Amino acid ABC transporter (Permease) KU6B_RS20905 ENOG4105C0Z ABC transporter KU6B_RS20915 ENOG4105BZU Histidine kinase KU6B_RS20920 ENOG4105DPZ Two component transcriptional regulator (Winged helix family KU6B_RS20940 ENOG4108IEG Formate dehydrogenase Alpha subunit KU6B_RS20960 ENOG41083MR nifu domain-containing protein KU6B_RS20965 ENOG41072GX Peptidase M22 Glycoprotease KU6B_RS20975 ENOG4105DIH basic membrane KU6B_RS20980 ENOG4108JQ9 ABC transporter KU6B_RS20985 ENOG4105UIB (ABC) transporter KU6B_RS21000 ENOG4108VCT Sulfite exporter TauE/SafE KU6B_RS21015 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) KU6B_RS21020 ENOG4105CYX Short-chain dehydrogenase reductase Sdr KU6B_RS21035 ENOG4108E8C ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) KU6B_RS21050 ENOG4105C25 Primosomal protein n' KU6B_RS21055 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) KU6B_RS21065 ENOG4107SKI cobyrinic Acid a,c-diamide synthase KU6B_RS21080 ENOG4105DK7 lysyl-tRNA synthetase KU6B_RS21105 ENOG4107WK2 Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) KU6B_RS21110 ENOG4105C8Q Methyl-accepting chemotaxis KU6B_RS21150 ENOG4105NAU thioesterase Superfamily protein KU6B_RS21155 ENOG4105NWF RbsD or FucU transport KU6B_RS21160 ENOG4105E8T Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) KU6B_RS21170 ENOG4105MMR Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly (By similarity) KU6B_RS21200 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) KU6B_RS21205 ENOG4105KI2 Urea amidohydrolase subunit beta KU6B_RS21215 ENOG4108YZ9 Urea amidohydrolase subunit gamma KU6B_RS21230 ENOG4105C32 Amino acid ABC transporter (Permease) KU6B_RS21235 ENOG4105CNN ABC, transporter KU6B_RS21240 ENOG4105C0Z ABC transporter KU6B_RS21245 ENOG4108IV0 ABC, transporter KU6B_RS21250 ENOG4105UT3 Methyl-accepting chemotaxis KU6B_RS21285 ENOG4105EAD ABC transporter KU6B_RS21290 ENOG4105CDA abc transporter atp-binding protein KU6B_RS21315 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) KU6B_RS21320 ENOG4105ETE Transcriptional regulator (LacI family KU6B_RS21325 ENOG4105D7K pfkb domain protein KU6B_RS21330 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) KU6B_RS21350 ENOG4105DH8 myo-inositol catabolism KU6B_RS21355 ENOG4105CQB FAD linked oxidase domain protein KU6B_RS21370 ENOG4105E09 nadh pyrophosphatase KU6B_RS21380 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 KU6B_RS21395 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) KU6B_RS21415 ENOG4107QMP dna polymerase iii subunits gamma and tau KU6B_RS21420 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) KU6B_RS21430 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) KU6B_RS21460 ENOG4105CEY Amp-dependent synthetase and ligase KU6B_RS21480 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) KU6B_RS21485 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) KU6B_RS21490 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) KU6B_RS21495 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) KU6B_RS21505 ENOG4105C6K Malic enzyme KU6B_RS21510 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) KU6B_RS21525 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) KU6B_RS21530 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) KU6B_RS21535 ENOG4108UMS Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase (By similarity) KU6B_RS21545 ENOG4105NX3 Membrane KU6B_RS21575 ENOG4105CPC Aldo Keto reductase KU6B_RS21595 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) KU6B_RS21605 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) KU6B_RS21620 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase KU6B_RS21630 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) KU6B_RS21655 ENOG41080HT Transcriptional regulator, arsr family KU6B_RS21660 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) KU6B_RS21665 ENOG4105CEY Amp-dependent synthetase and ligase KU6B_RS21680 ENOG4108RAV Conserved protein KU6B_RS21690 ENOG4108Z5K methylglyoxal synthase KU6B_RS21695 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) KU6B_RS21705 ENOG4105DE9 3-keto-5-aminohexanoate cleavage enzyme KU6B_RS21710 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) KU6B_RS21715 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) KU6B_RS21725 ENOG4105G63 Type III effector Hrp-dependent KU6B_RS21785 ENOG4105H1G trap transporter solute receptor taxi family KU6B_RS21795 ENOG4105CBG Sulfatase KU6B_RS21815 ENOG4105BZ1 (ABC) transporter KU6B_RS21830 ENOG4105CGH 5'-nucleotidase KU6B_RS21845 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase KU6B_RS21855 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) KU6B_RS21870 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) KU6B_RS21895 ENOG4105FD8 phosphonate metabolism protein PhnM KU6B_RS21900 ENOG4108TXN phosphonate metabolism protein KU6B_RS21910 ENOG4105HRV phosphonate c-p lyase system protein phnl KU6B_RS21915 ENOG4105ENV phosphonate C-P lyase system protein PhnK KU6B_RS21950 ENOG4105FD8 phosphonate metabolism protein PhnM KU6B_RS21965 ENOG4105S7S phosphonate abc transporter KU6B_RS21970 ENOG4105EHI Phosphonate ABC transporter, periplasmic KU6B_RS21990 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) KU6B_RS21995 ENOG4105CXC rtn protein KU6B_RS22005 ENOG4105CHR reductase KU6B_RS22015 ENOG4105ETT transcriptional Regulator, LysR family KU6B_RS22025 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) KU6B_RS22035 ENOG4105EAH synthase KU6B_RS22040 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) KU6B_RS22045 ENOG4105DJQ tetratricopeptide tpr_2 repeat protein KU6B_RS22065 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) KU6B_RS22075 ENOG4105CVM Molybdenum cofactor synthesis domain protein KU6B_RS22085 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b KU6B_RS22090 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) KU6B_RS22095 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) KU6B_RS22130 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) KU6B_RS22135 ENOG4108UJU UPF0301 protein KU6B_RS22145 ENOG4105BZS acriflavin resistance protein KU6B_RS22155 ENOG4108RIR Molybdenum cofactor biosynthesis protein KU6B_RS22165 ENOG410829K Lysine exporter protein (Lyse ygga) KU6B_RS22170 ENOG4108UN4 phage SPO1 DNA polymerase-related protein KU6B_RS22175 ENOG4105CXT aspartate transcarbamylase KU6B_RS22200 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) KU6B_RS22220 ENOG4108WWZ General secretion pathway protein J KU6B_RS22235 ENOG4108VAU general secretion pathway protein G KU6B_RS22275 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) KU6B_RS22280 ENOG4105E0X reductase KU6B_RS22285 ENOG4107RFB Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) KU6B_RS22300 ENOG4105CJ3 phosphate transporter KU6B_RS22305 ENOG4105C0B DNA polymerase III (alpha subunit) KU6B_RS22310 ENOG4105CGF Aromatic amino acid aminotransferase KU6B_RS22315 ENOG4105KHC sulfurtransferase KU6B_RS22325 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) KU6B_RS22335 ENOG4108Z2U ureidoglycolate hydrolase KU6B_RS22355 ENOG4105QV4 Tryptophan halogenase KU6B_RS22360 ENOG4107E2E PKHD-type hydroxylase KU6B_RS22370 ENOG4105UVJ 5-dehydro-4-deoxyglucarate dehydratase KU6B_RS22375 ENOG4105E9Z Nad-dependent epimerase dehydratase KU6B_RS22380 ENOG4105NTD Inherit from COG: Hydrolase KU6B_RS22395 ENOG41073TP transcriptional regulator KU6B_RS22410 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component KU6B_RS22415 ENOG4108JQ6 ABC transporter KU6B_RS22430 ENOG4105EQX glucarate dehydratase KU6B_RS22450 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit KU6B_RS22455 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit KU6B_RS22530 ENOG4107Z7P Ferredoxin KU6B_RS22565 ENOG4105ERH Fumarylacetoacetate hydrolase KU6B_RS22570 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr KU6B_RS22575 ENOG4105CTX dehydratase KU6B_RS22580 ENOG4105CTX dehydratase KU6B_RS22590 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) KU6B_RS22595 ENOG4105M10 Involved in the anomeric conversion of L-rhamnose (By similarity) KU6B_RS22600 ENOG4105DIA mandelate racemase muconate lactonizing KU6B_RS22610 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component KU6B_RS22715 ENOG4107SCJ type I restriction enzyme EcoKI subunit R KU6B_RS22740 ENOG4105CVR type I restriction-modification system KU6B_RS22770 ENOG4105DIQ Transcriptional regulator KU6B_RS22775 ENOG4105CAT Cytidine monophosphate kinase KU6B_RS22785 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase KU6B_RS22790 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) KU6B_RS22815 ENOG4108JU5 Magnesium and cobalt efflux protein KU6B_RS22825 ENOG4105C9A Phoh family KU6B_RS22835 ENOG4105UYK outer membrane protein a KU6B_RS22850 ENOG4108JA0 Oxidoreductase, FAD NAD(P)-binding domain protein KU6B_RS22865 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) KU6B_RS22875 ENOG4108RKI Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity) KU6B_RS22880 ENOG41090R7 Ferric uptake KU6B_RS22885 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase KU6B_RS22890 ENOG4107S9B Shikimate dehydrogenase KU6B_RS23110 ENOG4108N0N Phage Terminase Large Subunit KU6B_RS23255 ENOG4108PNI recT protein KU6B_RS23325 ENOG4105EW9 transcriptional regulator AsnC family KU6B_RS23350 ENOG4105ECY inositol monophosphatase KU6B_RS23405 ENOG4108UYE Lactoylglutathione lyase KU6B_RS23425 ENOG410903D sensor protein KU6B_RS23435 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) KU6B_RS23445 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) KU6B_RS23575 ENOG4105CBG Sulfatase KU6B_RS23585 ENOG4105D7T ABC transporter KU6B_RS23595 ENOG4105DS0 Transcriptional regulator, Crp Fnr family KU6B_RS23605 ENOG4108YAB Invasion protein KU6B_RS23680 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) KU6B_RS23685 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP KU6B_RS23695 ENOG4105C3R Methionine synthase KU6B_RS23700 ENOG4105SYT Methylenetetrahydrofolate reductase KU6B_RS23710 ENOG4108JJB ABC transporter KU6B_RS23715 ENOG4107YZB Cobalt transport protein KU6B_RS23755 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) KU6B_RS23820 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) KU6B_RS23855 ENOG4105K63 Thioredoxin KU6B_RS23875 ENOG4105CK6 Two component transcriptional regulator (Winged helix family KU6B_RS23905 ENOG4108R5F Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) KU6B_RS23915 ENOG4105EIX cytochrome c1 KU6B_RS23920 ENOG4107T0D ABC, transporter KU6B_RS23930 ENOG4105DP9 ABC transporter KU6B_RS23940 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase KU6B_RS23970 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) KU6B_RS23985 ENOG4105M74 Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) KU6B_RS23990 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) KU6B_RS23995 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) KU6B_RS24010 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) KU6B_RS24015 ENOG4108JHT EamA-like transporter family KU6B_RS24035 ENOG4105DGW oligopeptidase A KU6B_RS24040 ENOG4105D06 uba thif-type nad fad binding protein KU6B_RS24045 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) KU6B_RS24050 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase KU6B_RS24065 ENOG4108K3A Glutathione S-transferase KU6B_RS24070 ENOG4105C0P Mg chelatase subunit ChlI KU6B_RS24085 ENOG41082D8 UPF0102 protein KU6B_RS24090 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) KU6B_RS24100 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) KU6B_RS24125 ENOG4105C31 Tryptophanyl-tRNA synthetase KU6B_RS24145 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) KU6B_RS24150 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) KU6B_RS24175 ENOG4107TVJ ,Oxidoreductase FAD NAD(P)-binding KU6B_RS24190 ENOG4106BM2 Cupin domain KU6B_RS24195 ENOG4105CUC YeeE YedE family protein KU6B_RS24200 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) KU6B_RS24205 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) KU6B_RS24225 ENOG4105K5G 30S ribosomal protein S21 KU6B_RS24240 ENOG4105DZ1 carboxypeptidase KU6B_RS24250 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) KU6B_RS24255 ENOG4107VE0 Methyltransferase KU6B_RS24260 ENOG4105CHR reductase KU6B_RS24265 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) KU6B_RS24270 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase KU6B_RS24275 ENOG4108R99 pseudouridine synthase KU6B_RS24280 ENOG4108Z6B deaminase KU6B_RS24285 ENOG4105FE9 pseudouridine synthase KU6B_RS24305 ENOG4105CDW Resistance protein KU6B_RS24340 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) KU6B_RS24350 ENOG4108JJA ABC, transporter KU6B_RS24395 ENOG4105ES5 Histidine kinase KU6B_RS24400 ENOG4107QN2 dihydrolipoyl dehydrogenase KU6B_RS24410 ENOG4105VG0 50S ribosomal protein l34 KU6B_RS24415 ENOG4105KK3 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) KU6B_RS24420 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) KU6B_RS24425 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) KU6B_RS24430 ENOG4105BZU Histidine kinase KU6B_RS24435 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins KU6B_RS24445 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) KU6B_RS24450 ENOG4105CAS nag kinase KU6B_RS24465 ENOG4107QXX ABC transporter KU6B_RS24480 ENOG4105EI2 Pseudouridine synthase KU6B_RS24505 ENOG4105C0H protease KU6B_RS24520 ENOG4105C93 Xylose Isomerase KU6B_RS24525 ENOG4105CMG Carbohydrate kinase KU6B_RS24535 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) KU6B_RS24545 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase KU6B_RS24560 ENOG4105F7P transcriptional regulator AsnC family KU6B_RS24565 ENOG4105C3M thioredoxin reductase KU6B_RS24575 ENOG4107RIQ Sulfate adenylate transferase KU6B_RS24620 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) KU6B_RS24625 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit KU6B_RS24630 ENOG4105FD8 phosphonate metabolism protein PhnM KU6B_RS24660 ENOG4105D1F ATP-binding protein KU6B_RS24665 ENOG4105N5Q Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) KU6B_RS24670 ENOG4108VHN F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) KU6B_RS24675 ENOG4105VD1 ATP synthase subunit C KU6B_RS24680 ENOG4105EE4 it plays a direct role in the translocation of protons across the membrane (By similarity) KU6B_RS24705 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) KU6B_RS24715 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY KU6B_RS24750 ENOG4105K5M 30s ribosomal protein S16 KU6B_RS24755 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) KU6B_RS24765 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) KU6B_RS24785 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) KU6B_RS24790 ENOG41082FS 50S ribosomal protein L31 KU6B_RS24800 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) KU6B_RS24810 ENOG4105BZG amino acid carrier protein KU6B_RS24825 ENOG4105CHH sulfate transporter KU6B_RS24830 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) KU6B_RS24840 ENOG4108JQ1 Dehydrogenase KU6B_RS24855 ENOG4108ZJI phenylacetic acid degradation protein KU6B_RS24865 ENOG4105CYW agmatinase KU6B_RS24870 ENOG4107SN7 NLP P60 protein KU6B_RS24885 ENOG41077A9 carbonic anhydrase KU6B_RS24910 ENOG4105EWT decarboxylase family KU6B_RS24920 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) KU6B_RS24930 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) KU6B_RS24945 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) KU6B_RS24955 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) KU6B_RS24980 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) KU6B_RS24985 ENOG4105CN1 protease KU6B_RS24995 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) KU6B_RS25005 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain KU6B_RS25015 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase KU6B_RS25020 ENOG4105C9M aspartyl-trna synthetase KU6B_RS25060 ENOG41084XA UPF0235 protein KU6B_RS25105 ENOG41061DF Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P (By similarity) KU6B_RS25110 ENOG4107R5G Periplasmic binding protein LacI transcriptional regulator KU6B_RS25115 ENOG4105CNN ABC, transporter KU6B_RS25120 ENOG4105C2J ABC transporter KU6B_RS25125 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) KU6B_RS25130 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) KU6B_RS25135 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) KU6B_RS25140 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) KU6B_RS25150 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) KU6B_RS25155 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 KU6B_RS25165 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) KU6B_RS25180 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) KU6B_RS25185 ENOG4105M6F mutator MutT protein KU6B_RS25190 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) KU6B_RS25195 ENOG4107TF3 peptidylprolyl cis-trans isomerase KU6B_RS25200 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving KU6B_RS25215 ENOG4107S17 Phosphate-binding protein KU6B_RS25220 ENOG4105W5Q DNA repair protein (RadC KU6B_RS25230 ENOG4105CFG Acts as a chaperone (By similarity) KU6B_RS25255 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase KU6B_RS25295 ENOG4108S2Y peptide Chain Release factor KU6B_RS25305 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN KU6B_RS25310 ENOG4107TNS sigma 54 modulation protein ribosomal protein S30ea KU6B_RS25315 ENOG4108IUZ ABC transporter KU6B_RS25335 ENOG4105D3Q Sugar transferase KU6B_RS25340 ENOG4108M9J MaoC like domain protein KU6B_RS25345 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase KU6B_RS25355 ENOG4108ZG0 Ompa motb domain protein KU6B_RS25360 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) KU6B_RS25370 ENOG4105CSM endonuclease III KU6B_RS25395 ENOG4108UT2 hemolysin iii KU6B_RS25400 ENOG4105EUB pirin domain protein KU6B_RS25410 ENOG4105DA5 (ABC) transporter KU6B_RS25415 ENOG4105K59 histidine triad (HIT) protein KU6B_RS25430 ENOG4108YZG isomerase KU6B_RS25440 ENOG4105C7R Atpase associated with various cellular activities aaa_3 KU6B_RS25475 ENOG4105CQB FAD linked oxidase domain protein KU6B_RS25480 ENOG4105EU8 FAD linked oxidase domain protein KU6B_RS25490 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) KU6B_RS25500 ENOG4108ZNX Heat shock protein KU6B_RS25535 ENOG4105C26 Dehydrogenase KU6B_RS25575 ENOG4105RX8 Protein of unknown function (DUF1523) KU6B_RS25585 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein KU6B_RS25600 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) KU6B_RS25605 ENOG4105HM0 Sulfoacetaldehyde acetyltransferase KU6B_RS25655 ENOG4105EMU Dehydrogenase KU6B_RS25675 ENOG4107RA4 Glycosyl transferase (Group 1 KU6B_RS25685 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) KU6B_RS25690 ENOG4108QV3 biosynthesis protein KU6B_RS25730 ENOG4105CPK Glycosyl transferase (Group 1 KU6B_RS25750 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) KU6B_RS25760 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) KU6B_RS25765 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA KU6B_RS25785 ENOG4105C6Y Udp-glucose 6-dehydrogenase KU6B_RS25790 ENOG4105C2X Arabinose 5-phosphate isomerase KU6B_RS25795 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) KU6B_RS25800 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase KU6B_RS25825 ENOG4105HEE Binding Domain protein KU6B_RS25900 ENOG4105DZG Dehydrogenase KU6B_RS25935 ENOG4105BZU Histidine kinase KU6B_RS25945 ENOG4105CHY citrate lyase, alpha KU6B_RS25965 ENOG4105CYM Glutathione S-transferase KU6B_RS25970 ENOG4105IU3 Glutathione S-transferase KU6B_RS25995 ENOG41060W2 glyoxylate carboligase KU6B_RS26000 ENOG4105C7F AcnD-accessory protein PrpF KU6B_RS26005 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) KU6B_RS26025 ENOG4105DHQ Histidine kinase KU6B_RS26030 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) KU6B_RS26040 ENOG4105DRR Transcriptional regulator, GntR family KU6B_RS26050 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) KU6B_RS26055 ENOG4108IYU L-aspartate oxidase KU6B_RS26060 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase KU6B_RS26090 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase KU6B_RS26130 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) KU6B_RS26135 ENOG4108R7K Metal Dependent Phosphohydrolase KU6B_RS26145 ENOG410810E transcriptional regulator, lysR family KU6B_RS26150 ENOG4108UYB regulatoR KU6B_RS26160 ENOG4105TX3 Histidine kinase KU6B_RS26170 ENOG4108E87 P-loop hydrolase UPF0079 KU6B_RS26175 ENOG4105EHM Aminoglycoside phosphotransferase KU6B_RS26180 ENOG4108S0S Nucleotidyl transferase KU6B_RS26190 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation KU6B_RS26195 ENOG4105K63 Thioredoxin KU6B_RS26200 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) KU6B_RS26210 ENOG4107TE5 Lipid kinase KU6B_RS26215 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) KU6B_RS26220 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein KU6B_RS26230 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component KU6B_RS26235 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component KU6B_RS26245 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) KU6B_RS26260 ENOG4105VW4 glutaredoxin 3 KU6B_RS26265 ENOG4105MJ2 Competence protein KU6B_RS26270 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) KU6B_RS26275 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) KU6B_RS26295 ENOG4105F7V ErfK ybiS ycfS ynhG family protein KU6B_RS26320 ENOG4105BZ1 (ABC) transporter KU6B_RS26330 ENOG4105P8F nudix hydrolase KU6B_RS26335 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) KU6B_RS26340 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) KU6B_RS26345 ENOG4105CK6 Two component transcriptional regulator (Winged helix family KU6B_RS26360 ENOG4105C7B Threonine dehydratase KU6B_RS26370 ENOG4105CDH Citrulline--aspartate ligase KU6B_RS26385 ENOG4107R50 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) KU6B_RS26405 ENOG4105C6K Malic enzyme KU6B_RS26415 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ KU6B_RS26420 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) KU6B_RS26425 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) KU6B_RS26430 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) KU6B_RS26435 ENOG4105CSA Coproporphyrinogen iii oxidase KU6B_RS26455 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) KU6B_RS26460 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) KU6B_RS26465 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) KU6B_RS26470 ENOG4108UHJ MAF-like protein KU6B_RS26475 ENOG4105E2X shikimate dehydrogenase KU6B_RS26480 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) KU6B_RS26490 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) KU6B_RS26495 ENOG4105FS0 cytoplasmic membrane protein KU6B_RS26510 ENOG4105XAB Smr domain protein KU6B_RS26530 ENOG4105D3Q Sugar transferase KU6B_RS26540 ENOG4105E3R (LipO)protein KU6B_RS26545 ENOG4105ER2 Ompa motb domain protein KU6B_RS26550 ENOG4105BZE flagellar hook protein, FlgE KU6B_RS26565 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) KU6B_RS26570 ENOG4107RD7 Flagellar Motor Protein, MotA KU6B_RS26580 ENOG4105D7B Flagellar biosynthesis protein flha KU6B_RS26590 ENOG4105D00 flagellar biosynthetic protein flhB KU6B_RS26605 ENOG4107W7W Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) KU6B_RS26615 ENOG4105CGA flagellar basal-body rod protein FlgG KU6B_RS26620 ENOG4105KTQ flagellar basal-body rod protein KU6B_RS26625 ENOG4105VS8 Flagellar biosynthetic protein fliq KU6B_RS26635 ENOG4108ZC9 flagellar basal-body rod protein flgc KU6B_RS26655 ENOG4105IE4 repressor protein FlbT KU6B_RS26690 ENOG410822I Flagellar hook capping protein KU6B_RS26705 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) KU6B_RS26710 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) KU6B_RS26720 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) KU6B_RS26735 ENOG4108JE9 extracellular solute-binding protein family 1 KU6B_RS26740 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component KU6B_RS26755 ENOG4105CXK mandelate racemase muconate lactonizing KU6B_RS26765 ENOG4107QSN dihydrolipoamide acetyltransferase KU6B_RS26770 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) KU6B_RS26775 ENOG4105J0Q Transcriptional regulator KU6B_RS26795 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component KU6B_RS26800 ENOG4107TTD cytosine deaminase KU6B_RS26805 ENOG4105D4A Cell wall formation (By similarity) KU6B_RS26810 ENOG4107XKF NMT1 THI5 Like Domain Protein KU6B_RS26815 ENOG4108X0B nad(p)h dehydrogenase (quinone) KU6B_RS26820 ENOG4108IG5 Transcriptional regulator KU6B_RS26830 ENOG4107Z7P Ferredoxin KU6B_RS26850 ENOG4105EZ7 amino acid ABC transporter KU6B_RS26855 ENOG4105DRP amino acid AbC transporter KU6B_RS26860 ENOG4105CDA abc transporter atp-binding protein KU6B_RS26870 ENOG4105CBG Sulfatase KU6B_RS26875 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) KU6B_RS26880 ENOG4105MWK D-amino acid dehydrogenase, small subunit KU6B_RS26885 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr KU6B_RS26890 ENOG4105C26 Dehydrogenase KU6B_RS26900 ENOG4105CHR reductase KU6B_RS26905 ENOG4105CTU Proline racemase KU6B_RS26910 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) KU6B_RS26925 ENOG4105C26 Dehydrogenase KU6B_RS26935 ENOG4105E32 cytoplasmic protein KU6B_RS26955 ENOG4105CBG Sulfatase KU6B_RS26970 ENOG4105E45 Histidinol-phosphate aminotransferase KU6B_RS26975 ENOG4105CQB FAD linked oxidase domain protein KU6B_RS26980 ENOG4107QSI ABC, transporter KU6B_RS27005 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component KU6B_RS27020 ENOG4105CGP Urocanate hydratase KU6B_RS27030 ENOG4105C84 Histidine ammonia-lyase KU6B_RS27035 ENOG4105CI2 imidazolone-5-propionate hydrolase KU6B_RS27040 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) KU6B_RS27080 ENOG4105CEY Amp-dependent synthetase and ligase KU6B_RS27090 ENOG4108ZMQ domain protein KU6B_RS27105 ENOG4105DG4 malate L-lactate dehydrogenase KU6B_RS27110 ENOG4105H1G trap transporter solute receptor taxi family KU6B_RS27135 ENOG4105YAJ CopG Arc MetJ KU6B_RS27140 ENOG4105EZY Pyrroloquinoline quinone biosynthesis protein E KU6B_RS27145 ENOG4105Z85 coenzyme PQQ synthesis KU6B_RS27150 ENOG41086XE Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ (By similarity) KU6B_RS27155 ENOG4105JIE May be involved in the transport of PQQ or its precursor to the periplasm (By similarity) KU6B_RS27160 ENOG410698T Required for coenzyme pyrroloquinoline quinone (PQQ) biosynthesis. PQQ is probably formed by cross-linking a specific glutamate to a specific tyrosine residue and excising these residues from the peptide (By similarity) KU6B_RS27165 ENOG4105ETX regulatoR KU6B_RS27170 ENOG4105BZU Histidine kinase KU6B_RS27255 ENOG4108U4V Cytochrome c protein KU6B_RS27260 ENOG4105DZG Dehydrogenase KU6B_RS27265 ENOG4105XUA cytochrome c KU6B_RS27270 ENOG4105C4W S-formylglutathione hydrolase KU6B_RS27275 ENOG4107QPD alcohol dehydrogenase KU6B_RS27310 ENOG4105BZU Histidine kinase KU6B_RS27380 ENOG4105VT3 DNA binding domain protein, excisionase family KU6B_RS27395 ENOG4105DZR Type I site-specific deoxyribonuclease KU6B_RS27435 ENOG4108BUD transposase KU6B_RS27440 ENOG4107RUY (E1 component), alpha subunit KU6B_RS27455 ENOG4107QKR Dehydrogenase KU6B_RS27460 ENOG4108KMH lipoate-protein ligase a KU6B_RS27480 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) KU6B_RS27490 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) KU6B_RS27505 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) KU6B_RS27515 ENOG4105D06 uba thif-type nad fad binding protein KU6B_RS27520 ENOG4105DWF phosphomethylpyrimidine kinase KU6B_RS27625 ENOG4105W5Q DNA repair protein (RadC KU6B_RS27700 ENOG4105KCV RNA signal recognition particle 4.5S RNA KU6B_RS27705 ENOG4105CYM Glutathione S-transferase KU6B_RS27710 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) KU6B_RS27725 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase KU6B_RS27745 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) KU6B_RS27760 ENOG4105PF9 Transcriptional regulator KU6B_RS27805 ENOG4108EHY type IV secretion system KU6B_RS27810 ENOG4105CMA conjugation trbi family protein KU6B_RS27830 ENOG4105E4C Lytic transglycosylase catalytic KU6B_RS27890 ENOG4105DV0 amidase (EC 3.5.1.4 KU6B_RS27895 ENOG4105CEY Amp-dependent synthetase and ligase KU6B_RS27910 ENOG4105E0A ABC, transporter KU6B_RS27915 ENOG4108U1V ABC transporter, permease KU6B_RS27920 ENOG4105DQ5 transport system permease protein KU6B_RS27925 ENOG4108HUF Transporter KU6B_RS27960 ENOG4108RYK Nad-dependent epimerase dehydratase KU6B_RS27965 ENOG4105KVH Transcriptional regulator KU6B_RS27985 ENOG4105CZN Potassium uptake protein KU6B_RS27995 ENOG4108MES Periplasmic binding protein KU6B_RS28005 ENOG4105E0A ABC, transporter KU6B_RS28010 ENOG4108U1V ABC transporter, permease KU6B_RS28015 ENOG4105DQ5 transport system permease protein KU6B_RS28020 ENOG4108MES Periplasmic binding protein KU6B_RS28030 ENOG4105CG6 trap dicarboxylate transporter dctm subunit KU6B_RS28050 ENOG4105CAD extracellular ligand-binding receptor KU6B_RS28055 ENOG4105C0Z ABC transporter KU6B_RS28060 ENOG4108IV0 ABC, transporter KU6B_RS28065 ENOG4105C32 Amino acid ABC transporter (Permease) KU6B_RS28075 ENOG4107SKW Inherit from COG: Alpha beta hydrolase KU6B_RS28090 ENOG4105CEY Amp-dependent synthetase and ligase KU6B_RS28100 ENOG4105PF9 Transcriptional regulator KU6B_RS28110 ENOG4105EYH Exonuclease KU6B_RS28125 ENOG4105C5Q Transcriptional regulator KU6B_RS28195 ENOG4105E4C Lytic transglycosylase catalytic KU6B_RS28215 ENOG4105CMA conjugation trbi family protein KU6B_RS28240 ENOG4105PGM cation diffusion facilitator family transporter KU6B_RS28290 ENOG4108N5C SNARE associated Golgi protein-related protein KU6B_RS28315 ENOG4105E0F Histidine kinase KU6B_RS28325 ENOG4105DA4 cytochrome c-type biogenesis protein KU6B_RS28330 ENOG4107QX9 Thiol disulfide interChange protein KU6B_RS28335 ENOG4105KWW Biogenesis protein KU6B_RS28340 ENOG4106FI7 cytochrome c-type biogenesis protein KU6B_RS28395 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding KU6B_RS28400 ENOG4105E3B Multicopper oxidase KU6B_RS28410 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) KU6B_RS28465 ENOG4105E3B Multicopper oxidase KU6B_RS28565 ENOG4105W5Q DNA repair protein (RadC KU6B_RS28580 ENOG4108UUM single-stranded DNA-binding protein KU6B_RS28655 ENOG4105XJC Two component transcriptional regulator (Winged helix family KU6B_RS28700 ENOG4105FEQ ParB domain protein nuclease KU6B_RS28785 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) KU6B_RS28790 ENOG4105DB4 KU6B_RS28810 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) KU6B_RS28875 ENOG4107UNZ domain protein KU6B_RS28890 ENOG4105CMA conjugation trbi family protein KU6B_RS28900 ENOG4105PDG Type IV secretion system protein VirB8 KU6B_RS28920 ENOG4105E4C Lytic transglycosylase catalytic KU6B_RS28945 ENOG4105E4C Lytic transglycosylase catalytic KU6B_RS28970 ENOG4105CHU acetyl-coa acetyltransferase KU6B_RS28980 ENOG4105TPV KU6B_RS28990 ENOG4105F95 Monooxygenase KU6B_RS29010 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase KU6B_RS29035 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F