locus-tag	class	description
BG558_RS00005	COG0445	tRNA wobble uridine modification
BG558_RS00015	COG0357	Ribosomal RNA small subunit methyltransferase G
BG558_RS00030	COG0667	Aldo Keto reductase
BG558_RS00035	COG2271	Major facilitator Superfamily
BG558_RS00040	COG0584	glycerophosphoryl diester phosphodiesterase
BG558_RS00045	COG2271	Major facilitator Superfamily
BG558_RS00090	COG1129	ABC transporter
BG558_RS00095	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BG558_RS00100	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BG558_RS00105	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BG558_RS00110	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
BG558_RS00115	COG2731	YhcH YjgK YiaL family protein
BG558_RS00120	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
BG558_RS00155	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BG558_RS00160	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BG558_RS00185	COG2502	aspartate--ammonia ligase
BG558_RS00190	COG1522	sequence-specific DNA binding
BG558_RS00200	COG0716	FMN binding
BG558_RS00205	COG0747	negative chemotaxis
BG558_RS00230	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
BG558_RS00245	COG0259	pyridoxamine-phosphate oxidase activity
BG558_RS00255	COG3276	selenocysteine insertion sequence binding
BG558_RS00260	COG2358	TRAP transporter, solute receptor (TAXI family
BG558_RS00275	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BG558_RS00280	COG0569	domain protein
BG558_RS00285	COG3477	response to acidic pH
BG558_RS00290	COG1012	belongs to the aldehyde dehydrogenase family
BG558_RS00295	COG1454	alcohol dehydrogenase
BG558_RS00300	COG1263	PTS System
BG558_RS00300	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BG558_RS00305	COG1879	ABC-type sugar transport system periplasmic component
BG558_RS00310	COG1172	Belongs to the binding-protein-dependent transport system permease family
BG558_RS00315	COG1129	ABC transporter
BG558_RS00320	COG0235	Class ii aldolase
BG558_RS00325	COG4154	Belongs to the RbsD FucU family
BG558_RS00330	COG1070	Carbohydrate kinase
BG558_RS00335	COG2407	Converts the aldose L-fucose into the corresponding ketose L-fuculose
BG558_RS00340	COG1349	DNA-binding transcription factor activity
BG558_RS00380	COG1629	transport
BG558_RS00380	COG4206	TonB-dependent receptor
BG558_RS00400	COG3676	manually curated
BG558_RS00410	COG1757	Na H antiporter
BG558_RS00415	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BG558_RS00430	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
BG558_RS00435	COG1595	DNA-templated transcription, initiation
BG558_RS00450	COG0673	inositol 2-dehydrogenase activity
BG558_RS00455	COG1305	Transglutaminase-like
BG558_RS00465	COG2608	mercury ion transmembrane transporter activity
BG558_RS00470	COG3730	PTS system glucitol sorbitol-specific
BG558_RS00485	COG1028	Short-chain dehydrogenase reductase Sdr
BG558_RS00490	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
BG558_RS00495	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BG558_RS00500	COG1349	DNA-binding transcription factor activity
BG558_RS00505	COG0517	IMP dehydrogenase activity
BG558_RS00505	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
BG558_RS00525	COG3722	fumarate hydratase activity
BG558_RS00530	COG0471	metal ion transport
BG558_RS00530	COG0490	domain, Protein
BG558_RS00535	COG4214	carbohydrate transport
BG558_RS00540	COG1129	ABC transporter
BG558_RS00545	COG4213	ABC transporter substrate-binding protein
BG558_RS00550	COG2115	Belongs to the xylose isomerase family
BG558_RS00555	COG1070	Carbohydrate kinase
BG558_RS00565	COG3545	Serine hydrolase
BG558_RS00575	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
BG558_RS00580	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BG558_RS00585	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BG558_RS00590	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
BG558_RS00605	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BG558_RS00610	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BG558_RS00665	COG0697	spore germination
BG558_RS00670	COG0346	lactoylglutathione lyase activity
BG558_RS00675	COG1194	a g-specific adenine glycosylase
BG558_RS00680	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
BG558_RS00685	COG0741	lytic transglycosylase activity
BG558_RS00710	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BG558_RS00715	COG1349	DNA-binding transcription factor activity
BG558_RS00720	COG2084	Dehydrogenase
BG558_RS00725	COG3395	kinase activity
BG558_RS00730	COG0235	Class ii aldolase
BG558_RS00735	COG3622	Belongs to the hyi family
BG558_RS00740	COG2610	gluconate transmembrane transporter activity
BG558_RS00750	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
BG558_RS00775	COG4545	Glutaredoxin-related protein
BG558_RS00780	COG4804	nuclease activity
BG558_RS00805	COG2964	Protein conserved in bacteria
BG558_RS00820	COG2832	Protein of unknown function (DUF454)
BG558_RS00840	COG3085	chromosome segregation
BG558_RS00845	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
BG558_RS00855	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BG558_RS00865	COG0521	Mo-molybdopterin cofactor biosynthetic process
BG558_RS00885	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BG558_RS00930	COG1840	ABC-type Fe3 transport system, periplasmic component
BG558_RS00940	COG1349	DNA-binding transcription factor activity
BG558_RS00945	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BG558_RS00965	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BG558_RS00975	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
BG558_RS00985	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
BG558_RS00995	COG0200	Binds to the 23S rRNA
BG558_RS01000	COG0201	protein transport
BG558_RS01010	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
BG558_RS01020	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BG558_RS01025	COG0202	RNA polymerase activity
BG558_RS01030	COG0203	ribosomal protein L17
BG558_RS01035	COG1609	Transcriptional regulator
BG558_RS01035	COG2207	Transcriptional regulator
BG558_RS01040	COG1609	Transcriptional regulator
BG558_RS01045	COG3265	gluconokinase activity
BG558_RS01050	COG2610	gluconate transmembrane transporter activity
BG558_RS01065	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
BG558_RS01070	COG1012	belongs to the aldehyde dehydrogenase family
BG558_RS01075	COG3718	enzyme involved in inositol metabolism
BG558_RS01090	COG1129	ABC transporter
BG558_RS01095	COG1172	Belongs to the binding-protein-dependent transport system permease family
BG558_RS01100	COG0673	inositol 2-dehydrogenase activity
BG558_RS01115	COG0673	inositol 2-dehydrogenase activity
BG558_RS01125	COG3962	Belongs to the TPP enzyme family
BG558_RS01140	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BG558_RS01150	COG2190	(PTS) system
BG558_RS01150	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BG558_RS01150	COG1263	PTS System
BG558_RS01155	COG0228	four-way junction DNA binding
BG558_RS01160	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BG558_RS01165	COG0336	Belongs to the RNA methyltransferase TrmD family
BG558_RS01185	COG1694	Mazg nucleotide pyrophosphohydrolase
BG558_RS01190	COG2850	peptidyl-arginine hydroxylation
BG558_RS01195	COG0439	Biotin carboxylase
BG558_RS01200	COG0511	ligase activity, forming carbon-carbon bonds
BG558_RS01210	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
BG558_RS01225	COG1876	peptidase activity
BG558_RS01235	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
BG558_RS01240	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BG558_RS01250	COG0606	chelatase, subunit chli
BG558_RS01255	COG2267	carboxylic ester hydrolase activity
BG558_RS01285	COG3691	Protein conserved in bacteria
BG558_RS01295	COG1879	ABC-type sugar transport system periplasmic component
BG558_RS01300	COG1879	ABC-type sugar transport system periplasmic component
BG558_RS01310	COG4211	Belongs to the binding-protein-dependent transport system permease family
BG558_RS01330	COG4795	General secretion pathway protein
BG558_RS01345	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
BG558_RS01355	COG0747	negative chemotaxis
BG558_RS01380	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
BG558_RS01380	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
BG558_RS01385	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BG558_RS01400	COG1309	transcriptional regulator
BG558_RS01425	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BG558_RS01430	COG2003	Belongs to the UPF0758 family
BG558_RS01445	COG1349	DNA-binding transcription factor activity
BG558_RS01460	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
BG558_RS01465	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
BG558_RS01470	COG0076	glutamate decarboxylase activity
BG558_RS01475	COG3111	PFAM Bacterial OB fold (BOF) protein
BG558_RS01480	COG2249	NAD(P)H dehydrogenase (quinone) activity
BG558_RS01485	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
BG558_RS01490	COG3062	negative regulation of establishment of protein localization
BG558_RS01495	COG0243	molybdopterin cofactor binding
BG558_RS01500	COG0437	4 iron, 4 sulfur cluster binding
BG558_RS01505	COG0348	domain, Protein
BG558_RS01510	COG3043	anaerobic respiration
BG558_RS01515	COG3005	denitrification pathway
BG558_RS01520	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
BG558_RS01530	COG3005	denitrification pathway
BG558_RS01560	COG0494	nUDIX hydrolase
BG558_RS01580	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
BG558_RS01585	COG4145	pantothenate transmembrane transporter activity
BG558_RS01590	COG3924	membrane
BG558_RS01595	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
BG558_RS01600	COG2853	Lipoprotein
BG558_RS01605	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BG558_RS01615	COG1858	cytochrome C peroxidase
BG558_RS01640	COG2801	Transposase and inactivated derivatives
BG558_RS01660	COG1309	transcriptional regulator
BG558_RS01665	COG0583	DNA-binding transcription factor activity
BG558_RS01670	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
BG558_RS01670	COG0678	peroxiredoxin activity
BG558_RS01675	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
BG558_RS01680	COG1803	Methylglyoxal synthase
BG558_RS01685	COG1289	transmembrane transporter activity
BG558_RS01690	COG1943	Transposase
BG558_RS01695	COG2995	paraquat-inducible protein a
BG558_RS01700	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
BG558_RS01720	COG0416	fatty acid biosynthetic process
BG558_RS01730	COG1399	metal-binding, possibly nucleic acid-binding protein
BG558_RS01735	COG4137	Cytochrome C assembly protein
BG558_RS01740	COG4536	flavin adenine dinucleotide binding
BG558_RS01745	COG0733	neurotransmitter:sodium symporter activity
BG558_RS01755	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
BG558_RS01760	COG0513	Belongs to the DEAD box helicase family
BG558_RS01765	COG2801	Transposase and inactivated derivatives
BG558_RS01780	COG3423	Transcriptional regulator
BG558_RS01785	COG2932	Transcriptional regulator
BG558_RS01795	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
BG558_RS01800	COG0676	glucose-6-phosphate 1-epimerase activity
BG558_RS01810	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
BG558_RS01815	COG0024	Methionine aminopeptidase
BG558_RS01825	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
BG558_RS01830	COG1178	ABC-type Fe3 transport system permease component
BG558_RS01835	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BG558_RS01840	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BG558_RS01845	COG2190	(PTS) system
BG558_RS01850	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BG558_RS01855	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BG558_RS01860	COG1621	beta-fructofuranosidase activity
BG558_RS01875	COG1758	RNA polymerase activity
BG558_RS01880	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BG558_RS01895	COG0230	Belongs to the bacterial ribosomal protein bL34 family
BG558_RS01900	COG0594	ribonuclease P activity
BG558_RS01905	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
BG558_RS01925	COG0562	UDP-galactopyranose mutase
BG558_RS01960	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BG558_RS01970	COG1575	Belongs to the MenA family. Type 1 subfamily
BG558_RS01975	COG1720	tRNA m6t6A37 methyltransferase activity
BG558_RS01985	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BG558_RS01990	COG1047	Peptidyl-prolyl cis-trans
BG558_RS02000	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BG558_RS02005	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
BG558_RS02010	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BG558_RS02020	COG0745	RESPONSE REGULATOR receiver
BG558_RS02025	COG2129	metallophosphoesterase
BG558_RS02030	COG3172	ATPase kinase involved in NAD metabolism
BG558_RS02035	COG0196	riboflavin kinase activity
BG558_RS02040	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
BG558_RS02055	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BG558_RS02060	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BG558_RS02065	COG4172	Belongs to the ABC transporter superfamily
BG558_RS02070	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BG558_RS02075	COG0601	transmembrane transport
BG558_RS02080	COG0747	negative chemotaxis
BG558_RS02090	COG1686	Belongs to the peptidase S11 family
BG558_RS02105	COG1620	l-lactate permease
BG558_RS02110	COG0247	lactate metabolic process
BG558_RS02115	COG1139	Iron-sulfur cluster binding protein
BG558_RS02120	COG1556	Lactate utilization protein
BG558_RS02135	COG1561	YicC-like family, N-terminal region
BG558_RS02140	COG0354	folic acid binding
BG558_RS02145	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
BG558_RS02155	COG1129	ABC transporter
BG558_RS02160	COG1172	Belongs to the binding-protein-dependent transport system permease family
BG558_RS02165	COG1879	ABC-type sugar transport system periplasmic component
BG558_RS02170	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BG558_RS02175	COG1609	Transcriptional regulator
BG558_RS02180	COG2197	response regulator
BG558_RS02190	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
BG558_RS02205	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
BG558_RS02215	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BG558_RS02220	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
BG558_RS02225	COG0511	ligase activity, forming carbon-carbon bonds
BG558_RS02225	COG5016	pyruvate
BG558_RS02230	COG3630	sodium ion export across plasma membrane
BG558_RS02235	COG1914	H( )-stimulated, divalent metal cation uptake system
BG558_RS02240	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
BG558_RS02245	COG1984	allophanate hydrolase subunit 2
BG558_RS02250	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
BG558_RS02255	COG1793	dna ligase
BG558_RS02305	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
BG558_RS02315	COG0006	proline dipeptidase activity
BG558_RS02320	COG3030	protein affecting phage T7 exclusion by the F plasmid
BG558_RS02330	COG1187	pseudouridine synthase activity
BG558_RS02345	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BG558_RS02355	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BG558_RS02360	COG5413	integral membrane protein
BG558_RS02380	COG4166	transmembrane transport
BG558_RS02385	COG1254	Belongs to the acylphosphatase family
BG558_RS02390	COG0308	aminopeptidase N
BG558_RS02395	COG0748	coenzyme F420 binding
BG558_RS02410	COG0814	amino acid
BG558_RS02415	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BG558_RS02435	COG1487	ribonuclease activity
BG558_RS02440	COG2195	Cleaves the N-terminal amino acid of tripeptides
BG558_RS02475	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BG558_RS02480	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BG558_RS02485	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BG558_RS02490	COG1121	(ABC) transporter
BG558_RS02515	COG3063	Type IV pilus biogenesis stability protein PilW
BG558_RS02520	COG2183	response to ionizing radiation
BG558_RS02525	COG0778	Nitroreductase
BG558_RS02530	COG0616	signal peptide processing
BG558_RS02555	COG0477	Major facilitator Superfamily
BG558_RS02575	COG3978	acetolactate synthase activity
BG558_RS02590	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
BG558_RS02595	COG0437	4 iron, 4 sulfur cluster binding
BG558_RS02600	COG3301	Polysulphide reductase, NrfD
BG558_RS02605	COG1138	Cytochrome C-type biogenesis protein
BG558_RS02610	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BG558_RS02615	COG3088	subunit of a heme lyase
BG558_RS02615	COG4235	cytochrome complex assembly
BG558_RS02625	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BG558_RS02630	COG1127	ABC transporter
BG558_RS02635	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BG558_RS02640	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
BG558_RS02645	COG2854	intermembrane phospholipid transfer
BG558_RS02655	COG5007	Belongs to the BolA IbaG family
BG558_RS02660	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BG558_RS02665	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
BG558_RS02680	COG0494	nUDIX hydrolase
BG558_RS02710	COG2431	L-lysine efflux transmembrane transporter activity
BG558_RS02720	COG0501	Belongs to the peptidase M48B family
BG558_RS02725	COG1238	metal cluster binding
BG558_RS02730	COG2116	formate transmembrane transporter activity
BG558_RS02735	COG1882	Formate acetyltransferase
BG558_RS02745	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
BG558_RS02750	COG0339	signal peptide processing
BG558_RS02755	COG0077	Prephenate dehydratase
BG558_RS02755	COG1605	Chorismate mutase
BG558_RS02760	COG2841	Protein conserved in bacteria
BG558_RS02765	COG2268	Band 7 protein
BG558_RS02770	COG2801	Transposase and inactivated derivatives
BG558_RS02785	COG4773	Receptor
BG558_RS02790	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BG558_RS02800	COG1120	ATPase activity
BG558_RS02805	COG2814	Major facilitator Superfamily
BG558_RS02835	COG1120	ATPase activity
BG558_RS02840	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BG558_RS02855	COG4206	TonB-dependent receptor
BG558_RS02860	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
BG558_RS02880	COG1663	tetraacyldisaccharide 4'-kinase activity
BG558_RS02905	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
BG558_RS02910	COG0740	serine-type endopeptidase activity
BG558_RS02915	COG2166	iron-sulfur cluster assembly
BG558_RS02925	COG2226	methyltransferase
BG558_RS02935	COG1942	4-Oxalocrotonate Tautomerase
BG558_RS02940	COG0512	Glutamine amidotransferase of anthranilate synthase
BG558_RS02945	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BG558_RS02950	COG0009	L-threonylcarbamoyladenylate synthase
BG558_RS02955	COG1187	pseudouridine synthase activity
BG558_RS02960	COG3273	potassium ion transport
BG558_RS02960	COG0471	metal ion transport
BG558_RS02975	COG1640	4-alpha-glucanotransferase
BG558_RS03000	COG2965	DNA replication, synthesis of RNA primer
BG558_RS03020	COG0488	(ABC) transporter
BG558_RS03045	COG4657	Part of a membrane complex involved in electron transport
BG558_RS03050	COG2878	Part of a membrane complex involved in electron transport
BG558_RS03055	COG4656	Part of a membrane complex involved in electron transport
BG558_RS03060	COG2860	membrane
BG558_RS03065	COG4658	electron transport chain
BG558_RS03085	COG1560	Kdo2-lipid A biosynthetic process
BG558_RS03090	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BG558_RS03095	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
BG558_RS03100	COG1131	(ABC) transporter
BG558_RS03105	COG0842	Transport permease protein
BG558_RS03110	COG0725	ABC transporter, periplasmic molybdate-binding protein
BG558_RS03120	COG4149	molybdate abc transporter
BG558_RS03125	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
BG558_RS03130	COG2867	negative regulation of translational initiation
BG558_RS03135	COG2914	Belongs to the UPF0125 (RnfH) family
BG558_RS03145	COG2195	Cleaves the N-terminal amino acid of tripeptides
BG558_RS03160	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
BG558_RS03165	COG0194	GDP metabolic process
BG558_RS03170	COG1538	Outer membrane efflux protein
BG558_RS03175	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
BG558_RS03230	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BG558_RS03240	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BG558_RS03255	COG0732	type I restriction modification DNA specificity domain
BG558_RS03270	COG0488	(ABC) transporter
BG558_RS03275	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
BG558_RS03280	COG1611	Belongs to the LOG family
BG558_RS03285	COG3593	DNA synthesis involved in DNA repair
BG558_RS03290	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BG558_RS03320	COG4667	esterase of the alpha-beta hydrolase superfamily
BG558_RS03330	COG3719	Belongs to the RNase T2 family
BG558_RS03340	COG1252	NADH dehydrogenase
BG558_RS03345	COG1840	ABC-type Fe3 transport system, periplasmic component
BG558_RS03360	COG2252	PERMEase
BG558_RS03365	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BG558_RS03370	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BG558_RS03375	COG1862	Preprotein translocase
BG558_RS03380	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
BG558_RS03385	COG2017	converts alpha-aldose to the beta-anomer
BG558_RS03390	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
BG558_RS03395	COG1085	galactose-1-phosphate uridylyltransferase
BG558_RS03400	COG3739	integral membrane protein
BG558_RS03405	COG1408	metallophosphoesterase
BG558_RS03440	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BG558_RS03455	COG2801	Transposase and inactivated derivatives
BG558_RS03485	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BG558_RS03490	COG2233	PERMEase
BG558_RS03495	COG0167	dihydroorotate dehydrogenase activity
BG558_RS03500	COG4316	Uncharacterized protein conserved in bacteria (DUF2251)
BG558_RS03505	COG0148	phosphopyruvate hydratase activity
BG558_RS03510	COG2932	Transcriptional regulator
BG558_RS03515	COG3423	Transcriptional regulator
BG558_RS03525	COG2842	Transposition protein
BG558_RS03550	COG4396	Host-nuclease inhibitor protein Gam
BG558_RS03575	COG4382	Mu-like prophage protein Gp16
BG558_RS03580	COG3561	AntA/AntB antirepressor
BG558_RS03635	COG4383	Mu-like prophage protein gp29
BG558_RS03640	COG2369	cell adhesion
BG558_RS03645	COG5005	Phage virion morphogenesis
BG558_RS03660	COG4397	Mu-like prophage major head subunit gpT
BG558_RS03730	COG3299	homolog of phage Mu protein gp47
BG558_RS03755	COG3392	D12 class N6 adenine-specific DNA methyltransferase
BG558_RS03810	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BG558_RS03815	COG1472	Belongs to the glycosyl hydrolase 3 family
BG558_RS03820	COG0861	Integral membrane protein TerC family
BG558_RS03840	COG1584	GPR1 FUN34 yaaH family protein
BG558_RS03850	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BG558_RS03855	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BG558_RS03870	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BG558_RS03870	COG2190	(PTS) system
BG558_RS03870	COG1263	PTS System
BG558_RS03885	COG2920	part of a sulfur-relay system
BG558_RS03890	COG0670	Belongs to the BI1 family
BG558_RS03895	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BG558_RS03910	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
BG558_RS03915	COG0291	Belongs to the bacterial ribosomal protein bL35 family
BG558_RS03920	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BG558_RS03930	COG1965	Belongs to the frataxin family
BG558_RS03945	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BG558_RS03950	COG0564	pseudouridine synthase activity
BG558_RS03960	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
BG558_RS03965	COG1560	Kdo2-lipid A biosynthetic process
BG558_RS03970	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BG558_RS03980	COG1760	l-serine dehydratase
BG558_RS03995	COG2027	D-alanyl-D-alanine carboxypeptidase
BG558_RS04000	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BG558_RS04015	COG1441	menaquinone biosynthetic process
BG558_RS04025	COG2814	Major facilitator Superfamily
BG558_RS04030	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BG558_RS04035	COG0232	Belongs to the dGTPase family. Type 2 subfamily
BG558_RS04060	COG0564	pseudouridine synthase activity
BG558_RS04065	COG3023	N-Acetylmuramoyl-L-alanine amidase
BG558_RS04070	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
BG558_RS04085	COG0626	cystathionine gamma-synthase activity
BG558_RS04090	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
BG558_RS04105	COG1702	phosphate starvation-inducible protein PhoH
BG558_RS04130	COG0583	DNA-binding transcription factor activity
BG558_RS04135	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
BG558_RS04160	COG0815	Transfers the fatty acyl group on membrane lipoproteins
BG558_RS04180	COG2801	Transposase and inactivated derivatives
BG558_RS04190	COG3381	protein complex oligomerization
BG558_RS04200	COG0791	NLP P60 protein
BG558_RS04205	COG2932	Transcriptional regulator
BG558_RS04215	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
BG558_RS04220	COG0330	HflC and HflK could
BG558_RS04230	COG2990	Protein conserved in bacteria
BG558_RS04240	COG1643	Atp-dependent helicase
BG558_RS04260	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
BG558_RS04265	COG0534	Mate efflux family protein
BG558_RS04270	COG1074	ATP-dependent DNA helicase activity
BG558_RS04285	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
BG558_RS04290	COG0385	Bile acid
BG558_RS04295	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BG558_RS04300	COG0561	phosphatase activity
BG558_RS04310	COG1595	DNA-templated transcription, initiation
BG558_RS04315	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
BG558_RS04320	COG3026	antisigma factor binding
BG558_RS04330	COG0318	PFAM AMP-dependent synthetase and ligase
BG558_RS04335	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
BG558_RS04340	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BG558_RS04345	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BG558_RS04350	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
BG558_RS04355	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
BG558_RS04355	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
BG558_RS04360	COG1160	GTP binding
BG558_RS04370	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BG558_RS04380	COG1757	Na H antiporter
BG558_RS04385	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
BG558_RS04390	COG4172	Belongs to the ABC transporter superfamily
BG558_RS04395	COG0444	Belongs to the ABC transporter superfamily
BG558_RS04405	COG4166	transmembrane transport
BG558_RS04410	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BG558_RS04425	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BG558_RS04430	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
BG558_RS04435	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BG558_RS04435	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BG558_RS04440	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
BG558_RS04450	COG2801	Transposase and inactivated derivatives
BG558_RS04470	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
BG558_RS04480	COG2840	Smr protein MutS2
BG558_RS04485	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BG558_RS04495	COG0697	spore germination
BG558_RS04510	COG5002	protein histidine kinase activity
BG558_RS04510	COG2198	Histidine kinase
BG558_RS04510	COG0784	Response regulator, receiver
BG558_RS04515	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BG558_RS04525	COG1959	2 iron, 2 sulfur cluster binding
BG558_RS04535	COG0822	iron-sulfur transferase activity
BG558_RS04545	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
BG558_RS04555	COG2852	Protein conserved in bacteria
BG558_RS04570	COG0633	Ferredoxin
BG558_RS04575	COG2975	iron-sulfur cluster assembly
BG558_RS04580	COG1275	C4-dicarboxylate transporter malic acid transport protein
BG558_RS04585	COG0617	tRNA 3'-terminal CCA addition
BG558_RS04590	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BG558_RS04595	COG0730	response to heat
BG558_RS04600	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
BG558_RS04605	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
BG558_RS04615	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
BG558_RS04625	COG4969	Belongs to the N-Me-Phe pilin family
BG558_RS04630	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BG558_RS04635	COG1459	type II secretion system
BG558_RS04645	COG0237	dephospho-CoA kinase activity
BG558_RS04645	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
BG558_RS04650	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
BG558_RS04655	COG1466	dna polymerase III delta subunit
BG558_RS04660	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
BG558_RS04665	COG0495	leucyl-tRNA aminoacylation
BG558_RS04685	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
BG558_RS04700	COG3106	COG3106 Predicted ATPase
BG558_RS04705	COG3025	triphosphatase activity
BG558_RS04715	COG3140	Belongs to the UPF0181 family
BG558_RS04720	COG0564	pseudouridine synthase activity
BG558_RS04725	COG3098	single-species biofilm formation
BG558_RS04730	COG0135	phosphoribosylanthranilate isomerase activity
BG558_RS04730	COG0134	indole-3-glycerol-phosphate synthase activity
BG558_RS04735	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BG558_RS04735	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
BG558_RS04740	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BG558_RS04745	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BG558_RS04750	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BG558_RS04765	COG0750	zinc metalloprotease
BG558_RS04770	COG0575	Belongs to the CDS family
BG558_RS04775	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BG558_RS04780	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BG558_RS04790	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
BG558_RS04800	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
BG558_RS04825	COG1704	LemA family
BG558_RS04840	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
BG558_RS04840	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BG558_RS04840	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BG558_RS04845	COG1105	Belongs to the carbohydrate kinase PfkB family
BG558_RS04850	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
BG558_RS04850	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BG558_RS04855	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
BG558_RS04860	COG1523	belongs to the glycosyl hydrolase 13 family
BG558_RS04875	COG0058	SHG alpha-glucan phosphorylase activity
BG558_RS04880	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
BG558_RS04885	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
BG558_RS04890	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
BG558_RS04895	COG0583	DNA-binding transcription factor activity
BG558_RS04900	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BG558_RS04965	COG0582	viral genome integration into host DNA
BG558_RS04970	COG0582	viral genome integration into host DNA
BG558_RS04980	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BG558_RS04985	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BG558_RS04990	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
BG558_RS05000	COG3264	Mechanosensitive ion channel
BG558_RS05000	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
BG558_RS05005	COG0318	PFAM AMP-dependent synthetase and ligase
BG558_RS05015	COG0596	Alpha beta hydrolase
BG558_RS05020	COG2226	methyltransferase
BG558_RS05030	COG0586	Pfam SNARE associated Golgi protein
BG558_RS05040	COG0717	Belongs to the dCTP deaminase family
BG558_RS05045	COG0572	uridine kinase
BG558_RS05055	COG1077	Cell shape determining protein MreB Mrl
BG558_RS05060	COG1792	Involved in formation and maintenance of cell shape
BG558_RS05065	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
BG558_RS05070	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BG558_RS05075	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BG558_RS05080	COG3676	manually curated
BG558_RS05085	COG0121	glutamine amidotransferase
BG558_RS05090	COG0142	geranyltranstransferase activity
BG558_RS05095	COG1722	exodeoxyribonuclease VII activity
BG558_RS05100	COG0633	Ferredoxin
BG558_RS05100	COG3217	Mosc domain protein beta barrel domain protein
BG558_RS05105	COG1368	sulfuric ester hydrolase activity
BG558_RS05140	COG3561	AntA/AntB antirepressor
BG558_RS05180	COG3723	Recombinational DNA repair protein, rece pathway
BG558_RS05310	COG3179	chitinase
BG558_RS05330	COG3728	DNA packaging
BG558_RS05335	COG1783	phage Terminase large subunit
BG558_RS05395	COG1598	PFAM Uncharacterised protein family UPF0150
BG558_RS05400	COG1724	mRNA binding
BG558_RS05485	COG0671	phosphoesterase, PA-phosphatase related
BG558_RS05490	COG1534	Rna-binding protein
BG558_RS05495	COG0463	Glycosyl transferase, family 2
BG558_RS05500	COG0859	PFAM glycosyl transferase family 9
BG558_RS05510	COG0328	RNA-DNA hybrid ribonuclease activity
BG558_RS05515	COG1286	toxin biosynthetic process
BG558_RS05530	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
BG558_RS05555	COG0305	Participates in initiation and elongation during chromosome replication
BG558_RS05575	COG2801	Transposase and inactivated derivatives
BG558_RS05585	COG3691	Protein conserved in bacteria
BG558_RS05590	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BG558_RS05595	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BG558_RS05600	COG3084	Protein conserved in bacteria
BG558_RS05605	COG1763	Mo-molybdopterin cofactor biosynthetic process
BG558_RS05615	COG0676	glucose-6-phosphate 1-epimerase activity
BG558_RS05625	COG2801	Transposase and inactivated derivatives
BG558_RS05640	COG0629	single-stranded DNA binding
BG558_RS05645	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BG558_RS05650	COG0659	secondary active sulfate transmembrane transporter activity
BG558_RS05660	COG1122	ATPase activity
BG558_RS05670	COG1199	ATP-dependent helicase activity
BG558_RS05680	COG1346	cytolysis
BG558_RS05685	COG1132	(ABC) transporter
BG558_RS05700	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BG558_RS05705	COG0167	dihydroorotate dehydrogenase activity
BG558_RS05710	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
BG558_RS05715	COG0508	dehydrogenase complex catalyzes the overall conversion of
BG558_RS05720	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BG558_RS05745	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BG558_RS05750	COG3676	manually curated
BG558_RS05755	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
BG558_RS05760	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BG558_RS05780	COG4991	sh3 domain protein
BG558_RS05785	COG0306	phosphate transporter
BG558_RS05790	COG1392	Phosphate transport regulator
BG558_RS05795	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
BG558_RS05810	COG4604	ABC transporter, ATP-binding protein
BG558_RS05815	COG4605	iron ion homeostasis
BG558_RS05820	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BG558_RS05825	COG4607	ABC-type enterochelin transport system periplasmic component
BG558_RS05830	COG0305	Participates in initiation and elongation during chromosome replication
BG558_RS05835	COG3100	YcgL domain-containing protein
BG558_RS05840	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
BG558_RS05855	COG3676	manually curated
BG558_RS05880	COG3392	D12 class N6 adenine-specific DNA methyltransferase
BG558_RS05950	COG3723	Recombinational DNA repair protein, rece pathway
BG558_RS05975	COG3617	BRO family, N-terminal domain
BG558_RS06075	COG3179	chitinase
BG558_RS06100	COG5410	chromosome segregation
BG558_RS06245	COG5301	cellulose 1,4-beta-cellobiosidase activity
BG558_RS06270	COG0425	Belongs to the sulfur carrier protein TusA family
BG558_RS06275	COG2391	methyltransferase activity
BG558_RS06285	COG1172	Belongs to the binding-protein-dependent transport system permease family
BG558_RS06290	COG1172	Belongs to the binding-protein-dependent transport system permease family
BG558_RS06310	COG0697	spore germination
BG558_RS06315	COG1278	Cold shock
BG558_RS06360	COG3787	Belongs to the UPF0306 family
BG558_RS06370	COG1811	Na channel or pump
BG558_RS06380	COG3028	Belongs to the UPF0307 family
BG558_RS06385	COG0312	modulator of DNA gyrase
BG558_RS06390	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
BG558_RS06395	COG4409	exo-alpha-(2->6)-sialidase activity
BG558_RS06420	COG1496	oxidoreductase activity
BG558_RS06425	COG0251	oxidation-reduction process
BG558_RS06435	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BG558_RS06440	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BG558_RS06450	COG2211	Major facilitator Superfamily
BG558_RS06455	COG1085	galactose-1-phosphate uridylyltransferase
BG558_RS06460	COG2271	Major facilitator Superfamily
BG558_RS06470	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BG558_RS06490	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BG558_RS06500	COG1509	lysine 2,3-aminomutase activity
BG558_RS06505	COG0017	Asparaginyl-tRNA synthetase
BG558_RS06510	COG2925	Exonuclease
BG558_RS06520	COG0613	PHP domain protein
BG558_RS06535	COG2837	iron assimilation
BG558_RS06550	COG0556	nucleotide-excision repair
BG558_RS06560	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
BG558_RS06570	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
BG558_RS06575	COG0625	glutathione transferase activity
BG558_RS06580	COG2969	positive regulation of protein catabolic process
BG558_RS06595	COG0583	DNA-binding transcription factor activity
BG558_RS06600	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BG558_RS06615	COG2226	methyltransferase
BG558_RS06620	COG3036	rescue of stalled ribosome
BG558_RS06625	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
BG558_RS06630	COG1940	carbohydrate kinase activity
BG558_RS06630	COG1846	Transcriptional regulator
BG558_RS06635	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
BG558_RS06640	COG1522	sequence-specific DNA binding
BG558_RS06645	COG1674	ftsk spoiiie
BG558_RS06650	COG2321	neutral zinc metallopeptidase
BG558_RS06655	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
BG558_RS06660	COG1214	PFAM Peptidase M22, glycoprotease
BG558_RS06665	COG0730	response to heat
BG558_RS06670	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BG558_RS06675	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BG558_RS06680	COG3119	arylsulfatase activity
BG558_RS06685	COG0641	radical SAM
BG558_RS06690	COG1435	thymidine kinase activity
BG558_RS06695	COG3074	FtsZ-dependent cytokinesis
BG558_RS06700	COG1494	fructose-1,6-bisphosphatase
BG558_RS06710	COG0006	proline dipeptidase activity
BG558_RS06720	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
BG558_RS06720	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BG558_RS06725	COG0697	spore germination
BG558_RS06730	COG0440	acetolactate synthase activity
BG558_RS06735	COG0028	Belongs to the TPP enzyme family
BG558_RS06740	COG0288	reversible hydration of carbon dioxide
BG558_RS06745	COG0857	belongs to the CobB CobQ family
BG558_RS06745	COG0280	phosphate acetyltransferase
BG558_RS06755	COG0737	Belongs to the 5'-nucleotidase family
BG558_RS06820	COG2801	Transposase and inactivated derivatives
BG558_RS06845	COG0626	cystathionine gamma-synthase activity
BG558_RS06870	COG2363	Small membrane protein
BG558_RS06875	COG0659	secondary active sulfate transmembrane transporter activity
BG558_RS06880	COG0243	molybdopterin cofactor binding
BG558_RS06885	COG1049	propionate catabolic process, 2-methylcitrate cycle
BG558_RS06890	COG0538	isocitrate dehydrogenase activity
BG558_RS06910	COG2801	Transposase and inactivated derivatives
BG558_RS06930	COG0243	molybdopterin cofactor binding
BG558_RS06935	COG3005	denitrification pathway
BG558_RS06940	COG2909	trisaccharide binding
BG558_RS06950	COG0315	cyclic pyranopterin monophosphate synthase activity
BG558_RS06955	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
BG558_RS06960	COG0314	molybdopterin synthase activity
BG558_RS06965	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
BG558_RS06970	COG1444	tRNA N-acetyltransferase activity
BG558_RS06975	COG1448	Aminotransferase
BG558_RS06980	COG0285	dihydrofolate synthase activity
BG558_RS06990	COG3956	TIGRFAM MazG family protein
BG558_RS07015	COG0577	efflux transmembrane transporter activity
BG558_RS07015	COG1136	(ABC) transporter
BG558_RS07020	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
BG558_RS07025	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BG558_RS07030	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BG558_RS07080	COG3210	domain, Protein
BG558_RS07085	COG2831	hemolysin activation secretion protein
BG558_RS07095	COG1943	Transposase
BG558_RS07100	COG2333	competence protein COMEC
BG558_RS07100	COG0658	competence protein
BG558_RS07105	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
BG558_RS07110	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
BG558_RS07115	COG0737	Belongs to the 5'-nucleotidase family
BG558_RS07120	COG2801	Transposase and inactivated derivatives
BG558_RS07130	COG1737	Transcriptional regulator
BG558_RS07135	COG2731	YhcH YjgK YiaL family protein
BG558_RS07140	COG0248	Ppx GppA phosphatase
BG558_RS07145	COG2926	Belongs to the UPF0265 family
BG558_RS07150	COG1263	PTS System
BG558_RS07150	COG2190	(PTS) system
BG558_RS07150	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BG558_RS07155	COG0527	aspartate kinase activity
BG558_RS07160	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BG558_RS07185	COG0745	RESPONSE REGULATOR receiver
BG558_RS07190	COG5002	protein histidine kinase activity
BG558_RS07200	COG4785	May be involved in cell division
BG558_RS07205	COG0513	Belongs to the DEAD box helicase family
BG558_RS07210	COG0590	tRNA wobble adenosine to inosine editing
BG558_RS07215	COG2951	lytic endotransglycosylase activity
BG558_RS07220	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
BG558_RS07225	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
BG558_RS07230	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
BG558_RS07235	COG0195	Participates in both transcription termination and antitermination
BG558_RS07240	COG0779	Required for maturation of 30S ribosomal subunits
BG558_RS07250	COG0741	lytic transglycosylase activity
BG558_RS07255	COG0023	Translation Initiation Factor
BG558_RS07260	COG0284	orotidine-5'-phosphate decarboxylase activity
BG558_RS07265	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
BG558_RS07270	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
BG558_RS07280	COG0539	negative regulation of cytoplasmic translation
BG558_RS07285	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
BG558_RS07290	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BG558_RS07295	COG0791	NLP P60 protein
BG558_RS07305	COG0072	phenylalanine-tRNA ligase activity
BG558_RS07315	COG0778	Nitroreductase
BG558_RS07325	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
BG558_RS07340	COG3022	response to hydroperoxide
BG558_RS07350	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
BG558_RS07355	COG3105	Protein conserved in bacteria
BG558_RS07370	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BG558_RS07380	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BG558_RS07385	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BG558_RS07390	COG1309	transcriptional regulator
BG558_RS07400	COG3083	sulfuric ester hydrolase activity
BG558_RS07410	COG2814	Major facilitator Superfamily
BG558_RS07420	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
BG558_RS07430	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BG558_RS07435	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
BG558_RS07445	COG0589	response to stress
BG558_RS07455	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
BG558_RS07475	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
BG558_RS07515	COG0629	single-stranded DNA binding
BG558_RS07570	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BG558_RS07585	COG2801	Transposase and inactivated derivatives
BG558_RS07640	COG5301	cellulose 1,4-beta-cellobiosidase activity
BG558_RS07695	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
BG558_RS07745	COG4695	Portal protein
BG558_RS07750	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BG558_RS07765	COG5645	(Lipo)protein
BG558_RS07770	COG4172	Belongs to the ABC transporter superfamily
BG558_RS07775	COG4171	peptide transport system, permease
BG558_RS07780	COG4168	peptide transport system, permease
BG558_RS07785	COG4166	transmembrane transport
BG558_RS07790	COG3283	Transcriptional regulator of aromatic amino acids metabolism
BG558_RS07795	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
BG558_RS07800	COG2983	Belongs to the UPF0260 family
BG558_RS07805	COG0393	Putative heavy-metal-binding
BG558_RS07810	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
BG558_RS07820	COG3850	Histidine kinase
BG558_RS07825	COG0561	phosphatase activity
BG558_RS07835	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
BG558_RS07840	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BG558_RS07845	COG0739	heme binding
BG558_RS07850	COG1121	(ABC) transporter
BG558_RS07855	COG0567	Dehydrogenase, E1 component
BG558_RS07860	COG0508	dehydrogenase complex catalyzes the overall conversion of
BG558_RS07865	COG0045	succinate-CoA ligase (ADP-forming) activity
BG558_RS07870	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
BG558_RS07875	COG1115	amino acid carrier protein
BG558_RS07880	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
BG558_RS07885	COG3683	transport system, periplasmic component
BG558_RS08000	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BG558_RS08020	COG1783	phage Terminase large subunit
BG558_RS08025	COG3728	DNA packaging
BG558_RS08045	COG3179	chitinase
BG558_RS08105	COG0305	Participates in initiation and elongation during chromosome replication
BG558_RS08160	COG3617	BRO family, N-terminal domain
BG558_RS08175	COG3723	Recombinational DNA repair protein, rece pathway
BG558_RS08250	COG0281	malic enzyme
BG558_RS08250	COG0280	phosphate acetyltransferase
BG558_RS08255	COG0189	ligase activity
BG558_RS08265	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BG558_RS08275	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
BG558_RS08280	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BG558_RS08280	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BG558_RS08285	COG5339	Protein conserved in bacteria
BG558_RS08290	COG0159	tryptophan synthase activity
BG558_RS08300	COG4221	oxidoreductase activity
BG558_RS08305	COG1757	Na H antiporter
BG558_RS08310	COG2916	Histone family protein nucleoid-structuring protein H-NS
BG558_RS08315	COG0788	formyltetrahydrofolate deformylase activity
BG558_RS08320	COG2949	membrane
BG558_RS08325	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BG558_RS08330	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BG558_RS08335	COG1530	ribonuclease E activity
BG558_RS08345	COG1518	maintenance of DNA repeat elements
BG558_RS08390	COG1944	ATP diphosphatase activity
BG558_RS08395	COG0500	methyltransferase
BG558_RS08400	COG0187	DNA topoisomerase II activity
BG558_RS08420	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
BG558_RS08425	COG1349	DNA-binding transcription factor activity
BG558_RS08430	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BG558_RS08435	COG2915	High frequency lysogenization protein hflD homolog
BG558_RS08440	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
BG558_RS08445	COG4988	ABC transporter
BG558_RS08450	COG2911	Protein conserved in bacteria
BG558_RS08455	COG0729	surface antigen
BG558_RS08465	COG4942	peptidase
BG558_RS08475	COG0233	cytoplasmic translational termination
BG558_RS08480	COG0528	UMP kinase activity
BG558_RS08485	COG2194	sulfuric ester hydrolase activity
BG558_RS08500	COG1840	ABC-type Fe3 transport system, periplasmic component
BG558_RS08510	COG3842	ATPase activity
BG558_RS08515	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
BG558_RS08520	COG0433	COG0433 Predicted ATPase
BG558_RS08525	COG0513	Belongs to the DEAD box helicase family
BG558_RS08540	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
BG558_RS08550	COG0681	Belongs to the peptidase S26 family
BG558_RS08560	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
BG558_RS08575	COG2259	Doxx family
BG558_RS08590	COG3219	Protein conserved in bacteria
BG558_RS08595	COG1595	DNA-templated transcription, initiation
BG558_RS08610	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BG558_RS08625	COG1620	l-lactate permease
BG558_RS08630	COG0549	Belongs to the carbamate kinase family
BG558_RS08635	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
BG558_RS08640	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
BG558_RS08645	COG3257	ureidoglycine aminohydrolase activity
BG558_RS08655	COG1953	Uracil, thiamine, allantoin
BG558_RS08675	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
BG558_RS08680	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
BG558_RS08685	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BG558_RS08705	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
BG558_RS08710	COG0732	type I restriction modification DNA specificity domain
BG558_RS08720	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
BG558_RS08730	COG2350	Protein conserved in bacteria
BG558_RS08735	COG1607	acyl-coa hydrolase
BG558_RS08740	COG2917	probably involved in intracellular septation
BG558_RS08750	COG3092	negative regulation of chromosome organization
BG558_RS08760	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BG558_RS08765	COG0303	'Molybdopterin
BG558_RS08770	COG2095	MarC family integral membrane protein
BG558_RS08780	COG0488	(ABC) transporter
BG558_RS08795	COG0564	pseudouridine synthase activity
BG558_RS08810	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BG558_RS08820	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
BG558_RS08835	COG0823	Involved in the tonB-independent uptake of proteins
BG558_RS08840	COG3064	Membrane
BG558_RS08845	COG0848	biopolymer transport protein
BG558_RS08850	COG0811	peptide transport
BG558_RS08855	COG0824	Thioesterase
BG558_RS08870	COG1294	oxidase, subunit
BG558_RS08875	COG1271	oxidase subunit
BG558_RS08900	COG2801	Transposase and inactivated derivatives
BG558_RS08910	COG0494	nUDIX hydrolase
BG558_RS08940	COG0271	Belongs to the BolA IbaG family
BG558_RS08955	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BG558_RS08960	COG1678	Uncharacterized ACR, COG1678
BG558_RS08970	COG0628	permease
BG558_RS08975	COG1115	amino acid carrier protein
BG558_RS08980	COG1525	nuclease
BG558_RS09040	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BG558_RS09045	COG0205	6-phosphofructokinase activity
BG558_RS09055	COG0301	tRNA thio-modification
BG558_RS09055	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BG558_RS09080	COG0330	HflC and HflK could
BG558_RS09085	COG0330	HflC and HflK could
BG558_RS09090	COG3676	manually curated
BG558_RS09105	COG0542	response to heat
BG558_RS09115	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
BG558_RS09125	COG0295	cytidine deaminase activity
BG558_RS09135	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
BG558_RS09145	COG0187	DNA topoisomerase II activity
BG558_RS09165	COG2801	Transposase and inactivated derivatives
BG558_RS09175	COG0789	Transcriptional regulator
BG558_RS09180	COG2217	Heavy metal translocating P-type atpase
BG558_RS09185	COG2217	Heavy metal translocating P-type atpase
BG558_RS09195	COG0302	gtp cyclohydrolase
BG558_RS09200	COG3642	lipopolysaccharide core region biosynthetic process
BG558_RS09205	COG0489	protein tyrosine kinase activity
BG558_RS09210	COG4166	transmembrane transport
BG558_RS09215	COG2095	MarC family integral membrane protein
BG558_RS09220	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BG558_RS09225	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BG558_RS09230	COG2354	Protein conserved in bacteria
BG558_RS09235	COG3071	HemY protein
BG558_RS09240	COG2959	enzyme of heme biosynthesis
BG558_RS09250	COG0181	hydroxymethylbilane synthase activity
BG558_RS09255	COG1454	alcohol dehydrogenase
BG558_RS09255	COG1012	belongs to the aldehyde dehydrogenase family
BG558_RS09265	COG0531	amino acid
BG558_RS09275	COG2801	Transposase and inactivated derivatives
BG558_RS09285	COG1388	LysM domain
BG558_RS09285	COG0860	N-Acetylmuramoyl-L-alanine amidase
BG558_RS09290	COG0802	atpase or kinase
BG558_RS09295	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
BG558_RS09305	COG1519	Transferase
BG558_RS09310	COG0826	peptidase U32
BG558_RS09325	COG0795	lipopolysaccharide-transporting ATPase activity
BG558_RS09330	COG0795	lipopolysaccharide-transporting ATPase activity
BG558_RS09340	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BG558_RS09345	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BG558_RS09350	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
BG558_RS09365	COG3711	transcriptional antiterminator
BG558_RS09365	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BG558_RS09380	COG3716	PTS system mannose fructose sorbose family IID component
BG558_RS09385	COG3715	PTS system
BG558_RS09390	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BG558_RS09395	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BG558_RS09395	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
BG558_RS09400	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BG558_RS09420	COG1902	pentaerythritol trinitrate reductase activity
BG558_RS09430	COG1764	response to oxidative stress
BG558_RS09435	COG2207	Transcriptional regulator
BG558_RS09440	COG0813	purine-nucleoside phosphorylase activity
BG558_RS09450	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BG558_RS09460	COG1216	Glycosyl transferase, family 2
BG558_RS09465	COG1216	Glycosyl transferase, family 2
BG558_RS09475	COG3306	glycosyltransferase involved in LPS biosynthesis
BG558_RS09485	COG2244	polysaccharide biosynthetic process
BG558_RS09500	COG2089	acid synthase
BG558_RS09510	COG1434	Gram-negative-bacterium-type cell wall biogenesis
BG558_RS09515	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BG558_RS09525	COG1280	lysine exporter protein (LysE YggA)
BG558_RS09535	COG0436	Aminotransferase
BG558_RS09540	COG1169	isochorismate synthase
BG558_RS09555	COG0602	queuosine metabolic process
BG558_RS09560	COG0720	synthase
BG558_RS09570	COG2960	long-chain fatty acid transporting porin activity
BG558_RS09575	COG0166	Belongs to the GPI family
BG558_RS09600	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BG558_RS09605	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BG558_RS09615	COG0460	homoserine dehydrogenase
BG558_RS09615	COG0527	aspartate kinase activity
BG558_RS09620	COG0083	homoserine kinase activity
BG558_RS09625	COG0215	cysteine-tRNA ligase activity
BG558_RS09630	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BG558_RS09650	COG0437	4 iron, 4 sulfur cluster binding
BG558_RS09655	COG2864	formate dehydrogenase
BG558_RS09660	COG3058	Necessary for formate dehydrogenase activity
BG558_RS09670	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BG558_RS09680	COG0778	Nitroreductase
BG558_RS09685	COG4172	Belongs to the ABC transporter superfamily
BG558_RS09690	COG0191	fructose-bisphosphate aldolase activity
BG558_RS09695	COG0126	phosphoglycerate kinase activity
BG558_RS09700	COG0733	neurotransmitter:sodium symporter activity
BG558_RS09705	COG0338	D12 class N6 adenine-specific DNA methyltransferase
BG558_RS09710	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
BG558_RS09715	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BG558_RS09725	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
BG558_RS09750	COG4796	Type ii and iii secretion system protein
BG558_RS09755	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BG558_RS09760	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
BG558_RS09765	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
BG558_RS09770	COG1280	lysine exporter protein (LysE YggA)
BG558_RS09775	COG0632	four-way junction helicase activity
BG558_RS09780	COG2255	four-way junction helicase activity
BG558_RS09785	COG4160	amino acid transport
BG558_RS09790	COG4215	(ABC) transporter
BG558_RS09795	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BG558_RS09800	COG1126	abc transporter atp-binding protein
BG558_RS09805	COG4232	protein-disulfide reductase activity
BG558_RS09810	COG3101	peptidyl-lysine hydroxylation
BG558_RS09815	COG1022	Amp-dependent synthetase and ligase
BG558_RS09820	COG0251	oxidation-reduction process
BG558_RS09830	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BG558_RS09835	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
BG558_RS09840	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
BG558_RS09845	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
BG558_RS09855	COG0287	Prephenate dehydrogenase
BG558_RS09855	COG1605	Chorismate mutase
BG558_RS09860	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
BG558_RS09865	COG0859	PFAM glycosyl transferase family 9
BG558_RS09870	COG0469	pyruvate kinase activity
BG558_RS09875	COG2062	phosphohistidine phosphatase, SixA
BG558_RS09880	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BG558_RS09890	COG4771	TonB-dependent receptor
BG558_RS09890	COG1629	transport
BG558_RS09900	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BG558_RS09905	COG0346	lactoylglutathione lyase activity
BG558_RS09920	COG2911	Protein conserved in bacteria
BG558_RS09930	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BG558_RS09935	COG0617	tRNA 3'-terminal CCA addition
BG558_RS09940	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
BG558_RS09945	COG4143	(ABC) transporter
BG558_RS09950	COG0402	S-adenosylhomocysteine deaminase activity
BG558_RS09955	COG3753	Protein conserved in bacteria
BG558_RS09965	COG0492	ferredoxin-NADP+ reductase activity
BG558_RS09970	COG2376	Dihydroxyacetone kinase
BG558_RS09975	COG1461	Dihydroxyacetone kinase
BG558_RS09980	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
BG558_RS09980	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BG558_RS09980	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BG558_RS09985	COG3118	belongs to the thioredoxin family
BG558_RS10015	COG3115	cell septum assembly
BG558_RS10040	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BG558_RS10050	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BG558_RS10050	COG0475	glutathione-regulated potassium exporter activity
BG558_RS10060	COG4580	involved in the transport of maltose and maltodextrins
BG558_RS10065	COG3842	ATPase activity
BG558_RS10075	COG1175	transmembrane transport
BG558_RS10080	COG3833	ABC-type maltose transport systems, permease component
BG558_RS10085	COG0366	Alpha amylase catalytic
BG558_RS10090	COG2909	trisaccharide binding
BG558_RS10095	COG0058	SHG alpha-glucan phosphorylase activity
BG558_RS10100	COG1640	4-alpha-glucanotransferase
BG558_RS10110	COG2056	Na+-H+ antiporter family
BG558_RS10115	COG0708	Exodeoxyribonuclease III
BG558_RS10120	COG3117	lipopolysaccharide transmembrane transporter activity
BG558_RS10125	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
BG558_RS10130	COG1137	ATPase activity
BG558_RS10135	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BG558_RS10145	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BG558_RS10160	COG2177	Part of the ABC transporter FtsEX involved in
BG558_RS10165	COG2884	Cell division ATP-binding protein ftsE
BG558_RS10170	COG0552	protein localization to endoplasmic reticulum
BG558_RS10175	COG0742	ribosomal rna small subunit methyltransferase
BG558_RS10180	COG3099	Belongs to the UPF0263 family
BG558_RS10185	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BG558_RS10195	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
BG558_RS10200	COG3326	Membrane
BG558_RS10205	COG1027	Aspartate ammonia-lyase
BG558_RS10210	COG0210	DNA helicase
BG558_RS10215	COG3842	ATPase activity
BG558_RS10220	COG1176	ABC-type spermidine putrescine transport system, permease component I
BG558_RS10225	COG1177	transmembrane transport
BG558_RS10230	COG0601	transmembrane transport
BG558_RS10235	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BG558_RS10240	COG4172	Belongs to the ABC transporter superfamily
BG558_RS10260	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BG558_RS10265	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
BG558_RS10270	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
BG558_RS10290	COG2801	Transposase and inactivated derivatives
BG558_RS10310	COG2801	Transposase and inactivated derivatives
BG558_RS10390	COG0740	serine-type endopeptidase activity
BG558_RS10430	COG3179	chitinase
BG558_RS10470	COG1403	HNH endonuclease
BG558_RS10515	COG1724	mRNA binding
BG558_RS10520	COG1598	PFAM Uncharacterised protein family UPF0150
BG558_RS10550	COG0629	single-stranded DNA binding
BG558_RS10585	COG3392	D12 class N6 adenine-specific DNA methyltransferase
BG558_RS10605	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BG558_RS10625	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BG558_RS10630	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BG558_RS10635	COG0483	inositol monophosphate 1-phosphatase activity
BG558_RS10640	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BG558_RS10645	COG1966	Carbon starvation protein
BG558_RS10650	COG0084	hydrolase, TatD family'
BG558_RS10675	COG4591	ABC-type transport system involved in lipoprotein release permease component
BG558_RS10680	COG1136	(ABC) transporter
BG558_RS10685	COG4591	ABC-type transport system involved in lipoprotein release permease component
BG558_RS10690	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BG558_RS10715	COG0512	Glutamine amidotransferase of anthranilate synthase
BG558_RS10720	COG1322	Protein conserved in bacteria
BG558_RS10720	COG1322	Protein conserved in bacteria
BG558_RS10730	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BG558_RS10740	COG2137	regulation of response to DNA damage stimulus
BG558_RS10750	COG0551	DNA topoisomerase type I activity
BG558_RS10755	COG0009	L-threonylcarbamoyladenylate synthase
BG558_RS10760	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BG558_RS10785	COG0210	DNA helicase
BG558_RS10790	COG1090	epimerase
BG558_RS10810	COG1666	GTP binding
BG558_RS10815	COG0560	Phosphoserine phosphatase
BG558_RS10825	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
BG558_RS10830	COG2081	HI0933 family
BG558_RS10835	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
BG558_RS10840	COG2252	PERMEase
BG558_RS10845	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BG558_RS10855	COG0716	FMN binding
BG558_RS10860	COG0735	belongs to the Fur family
BG558_RS10865	COG3008	intermembrane lipid transfer
BG558_RS10870	COG1854	S-ribosylhomocysteine lyase activity
BG558_RS10875	COG1132	(ABC) transporter
BG558_RS10880	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BG558_RS10885	COG0592	DNA-directed DNA polymerase activity
BG558_RS10890	COG2976	Protein conserved in bacteria
BG558_RS10900	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
BG558_RS10905	COG1426	Protein conserved in bacteria
BG558_RS10910	COG0165	Argininosuccinate lyase
BG558_RS10930	COG2801	Transposase and inactivated derivatives
BG558_RS10940	COG2801	Transposase and inactivated derivatives
BG558_RS10950	COG2991	Protein conserved in bacteria
BG558_RS10955	COG1477	protein flavinylation
BG558_RS10960	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
BG558_RS10965	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
BG558_RS10970	COG2871	sodium ion transport
BG558_RS10975	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
BG558_RS10980	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
BG558_RS10985	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
BG558_RS10990	COG1805	sodium ion transport
BG558_RS11000	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
BG558_RS11000	COG0316	Belongs to the HesB IscA family
BG558_RS11010	COG0252	asparaginase activity
BG558_RS11020	COG0583	DNA-binding transcription factor activity
BG558_RS11025	COG1011	Hydrolase
BG558_RS11030	COG0583	DNA-binding transcription factor activity
BG558_RS11035	COG1162	GTPase activity
BG558_RS11045	COG0537	adenosine 5'-monophosphoramidase activity
BG558_RS11055	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BG558_RS11060	COG3108	Peptidase M15
BG558_RS11065	COG2989	Protein conserved in bacteria
BG558_RS11070	COG0793	Belongs to the peptidase S41A family
BG558_RS11075	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
BG558_RS11085	COG2814	Major facilitator Superfamily
BG558_RS11090	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BG558_RS11100	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BG558_RS11130	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
BG558_RS11135	COG0792	nuclease activity
BG558_RS11140	COG3107	peptidoglycan biosynthetic process
BG558_RS11160	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BG558_RS11165	COG1414	Transcriptional regulator
BG558_RS11170	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BG558_RS11180	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
BG558_RS11195	COG3068	Protein conserved in bacteria
BG558_RS11210	COG1530	ribonuclease E activity
BG558_RS11220	COG4977	sequence-specific DNA binding
BG558_RS11220	COG1917	Cupin 2, conserved barrel domain protein
BG558_RS11230	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
BG558_RS11235	COG2824	Alkylphosphonate utilization operon protein PhnA
BG558_RS11240	COG0557	exoribonuclease II activity
BG558_RS11260	COG3116	cell division
BG558_RS11265	COG0768	penicillin binding
BG558_RS11270	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BG558_RS11280	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BG558_RS11285	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BG558_RS11290	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BG558_RS11295	COG0772	Belongs to the SEDS family
BG558_RS11300	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BG558_RS11310	COG1181	Belongs to the D-alanine--D-alanine ligase family
BG558_RS11320	COG0849	cell division
BG558_RS11335	COG0497	DNA recombination
BG558_RS11370	COG2801	Transposase and inactivated derivatives
BG558_RS11380	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BG558_RS11395	COG3077	Addiction module antitoxin, RelB DinJ family
BG558_RS11400	COG3041	Addiction module toxin RelE StbE family
BG558_RS11415	COG1295	ribonuclease BN
BG558_RS11420	COG1490	D-aminoacyl-tRNA deacylase activity
BG558_RS11430	COG1114	Component of the transport system for branched-chain amino acids
BG558_RS11435	COG1028	Short-chain dehydrogenase reductase Sdr
BG558_RS11445	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
BG558_RS11450	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BG558_RS11455	COG0142	geranyltranstransferase activity
BG558_RS11460	COG0261	This protein binds to 23S rRNA in the presence of protein L20
BG558_RS11470	COG0697	spore germination
BG558_RS11475	COG0697	spore germination
BG558_RS11480	COG0561	phosphatase activity
BG558_RS11485	COG1040	competence protein
BG558_RS11490	COG2259	Doxx family
BG558_RS11495	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
BG558_RS11505	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
BG558_RS11515	COG2801	Transposase and inactivated derivatives
BG558_RS11525	COG0783	Belongs to the Dps family
BG558_RS11530	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BG558_RS11535	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
BG558_RS11550	COG3676	manually curated
BG558_RS11560	COG2801	Transposase and inactivated derivatives
BG558_RS11600	COG2801	Transposase and inactivated derivatives
BG558_RS11635	COG1652	LysM domain
BG558_RS11640	COG2927	DNA polymerase III (CHI subunit)
BG558_RS11645	COG2153	protein acetylation
BG558_RS11650	COG3177	Filamentation induced by cAMP protein fic
BG558_RS11655	COG4185	zeta toxin
BG558_RS11665	COG0525	valine-tRNA ligase activity
BG558_RS11675	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
BG558_RS11680	COG1794	racemase activity, acting on amino acids and derivatives
BG558_RS11690	COG0363	glucosamine-6-phosphate deaminase activity
BG558_RS11695	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BG558_RS11700	COG1218	3'(2'),5'-bisphosphate nucleotidase
BG558_RS11705	COG0494	nUDIX hydrolase
BG558_RS11710	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
BG558_RS11730	COG0107	imidazoleglycerol-phosphate synthase activity
BG558_RS11745	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
BG558_RS11760	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
BG558_RS11760	COG0131	Imidazoleglycerol-phosphate dehydratase
BG558_RS11785	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
BG558_RS11790	COG0456	acetyltransferase
BG558_RS11795	COG1217	gtp-binding protein TYPA
BG558_RS11805	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
BG558_RS11825	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BG558_RS11835	COG0582	viral genome integration into host DNA
BG558_RS11860	COG1045	serine acetyltransferase
BG558_RS11865	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
BG558_RS11870	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
BG558_RS11875	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BG558_RS11880	COG0544	peptidyl-prolyl cis-trans isomerase activity
BG558_RS11890	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BG558_RS11895	COG0049	tRNA binding
BG558_RS11900	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BG558_RS11905	COG0859	PFAM glycosyl transferase family 9
BG558_RS11910	COG0859	PFAM glycosyl transferase family 9
BG558_RS11920	COG3061	Opacity-associated protein A
BG558_RS11920	COG3266	domain, Protein
BG558_RS11925	COG1555	photosystem II stabilization
BG558_RS11930	COG0688	phosphatidylethanolamine metabolic process
BG558_RS11955	COG4974	Belongs to the 'phage' integrase family
BG558_RS11960	COG0732	type I restriction modification DNA specificity domain
BG558_RS11970	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BG558_RS11970	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
BG558_RS11975	COG3715	PTS system
BG558_RS11980	COG3716	PTS system mannose fructose sorbose family IID component
BG558_RS12000	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
BG558_RS12005	COG1238	metal cluster binding
BG558_RS12020	COG4942	peptidase
BG558_RS12020	COG1388	LysM domain
BG558_RS12030	COG2818	Glycosylase
BG558_RS12035	COG2801	Transposase and inactivated derivatives
BG558_RS12050	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BG558_RS12060	COG0257	Belongs to the bacterial ribosomal protein bL36 family
BG558_RS12065	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BG558_RS12070	COG0765	amino acid transport
BG558_RS12075	COG1126	abc transporter atp-binding protein
BG558_RS12080	COG0762	integral membrane protein
BG558_RS12090	COG3171	Protein conserved in bacteria
BG558_RS12095	COG0220	tRNA (guanine-N7-)-methyltransferase activity
BG558_RS12100	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BG558_RS12110	COG0805	protein transport
BG558_RS12115	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BG558_RS12120	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BG558_RS12125	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BG558_RS12130	COG4804	nuclease activity
BG558_RS12135	COG3165	ubiquinone biosynthetic process from chorismate
BG558_RS12140	COG2226	methyltransferase
BG558_RS12145	COG0598	Magnesium transport protein CorA
BG558_RS12160	COG2801	Transposase and inactivated derivatives
BG558_RS12190	COG0347	Belongs to the P(II) protein family
BG558_RS12210	COG0753	catalase activity
BG558_RS12215	COG0425	Belongs to the sulfur carrier protein TusA family
BG558_RS12220	COG2391	methyltransferase activity
BG558_RS12225	COG2391	methyltransferase activity
BG558_RS12235	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BG558_RS12240	COG1393	Belongs to the ArsC family
BG558_RS12245	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
BG558_RS12250	COG0564	pseudouridine synthase activity
BG558_RS12260	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
BG558_RS12270	COG0431	NADPH-dependent FMN reductase
BG558_RS12280	COG1902	pentaerythritol trinitrate reductase activity
BG558_RS12285	COG0778	Nitroreductase
BG558_RS12295	COG0604	alcohol dehydrogenase
BG558_RS12295	COG1028	Short-chain dehydrogenase reductase Sdr
BG558_RS12295	COG3321	synthase
BG558_RS12310	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BG558_RS12320	COG2801	Transposase and inactivated derivatives
BG558_RS12335	COG0494	nUDIX hydrolase
BG558_RS12340	COG0730	response to heat
BG558_RS12350	COG0546	phosphoglycolate phosphatase activity
BG558_RS12365	COG0180	Tryptophanyl-tRNA synthetase
BG558_RS12370	COG0501	Belongs to the peptidase M48B family
BG558_RS12375	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
BG558_RS12395	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BG558_RS12400	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
BG558_RS12405	COG0470	DNA polymerase III
BG558_RS12420	COG0084	hydrolase, TatD family'
BG558_RS12430	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BG558_RS12435	COG1215	transferase activity, transferring glycosyl groups
BG558_RS12480	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
BG558_RS12495	COG0174	glutamine synthetase
BG558_RS12500	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BG558_RS12510	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
BG558_RS12520	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BG558_RS12540	COG0085	RNA polymerase activity
BG558_RS12555	COG2168	tRNA wobble position uridine thiolation
BG558_RS12565	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
BG558_RS12570	COG2964	Protein conserved in bacteria
BG558_RS12575	COG0545	Peptidyl-prolyl cis-trans isomerase
BG558_RS12580	COG2900	Belongs to the SlyX family
BG558_RS12590	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BG558_RS12595	COG3914	O-linked N-acetylglucosamine transferase SPINDLY family
BG558_RS12605	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
BG558_RS12610	COG1328	CTP reductase activity
BG558_RS12625	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BG558_RS12635	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BG558_RS12645	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BG558_RS12650	COG1028	Short-chain dehydrogenase reductase Sdr
BG558_RS12665	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BG558_RS12680	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BG558_RS12690	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BG558_RS12710	COG0758	DNA mediated transformation
BG558_RS12725	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BG558_RS12730	COG1067	ATP-dependent peptidase activity
BG558_RS12735	COG3120	sequence-specific DNA binding
BG558_RS12745	COG0277	FAD linked oxidase domain protein
BG558_RS12745	COG0247	lactate metabolic process
BG558_RS12750	COG2050	protein possibly involved in aromatic compounds catabolism
BG558_RS12765	COG0204	Acyl-transferase
BG558_RS12775	COG0825	malonyl-CoA metabolic process
BG558_RS12795	COG2801	Transposase and inactivated derivatives
BG558_RS12805	COG0235	Class ii aldolase
BG558_RS12810	COG3623	hexulose-6-phosphate isomerase
BG558_RS12830	COG0737	Belongs to the 5'-nucleotidase family
BG558_RS12850	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
BG558_RS12855	COG1929	Belongs to the glycerate kinase type-1 family
BG558_RS12860	COG2610	gluconate transmembrane transporter activity
BG558_RS12865	COG3835	regulator
BG558_RS12880	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BG558_RS12885	COG0840	transmembrane signaling receptor activity
BG558_RS12910	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
BG558_RS12920	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
BG558_RS12930	COG0089	rRNA binding
BG558_RS12935	COG0088	Forms part of the polypeptide exit tunnel
BG558_RS12940	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BG558_RS12945	COG0051	transcription antitermination factor activity, RNA binding
BG558_RS12950	COG3070	regulator of competence-specific genes
BG558_RS12965	COG0019	diaminopimelate decarboxylase activity
BG558_RS12970	COG0625	glutathione transferase activity
BG558_RS12980	COG2264	protein methyltransferase activity
BG558_RS13020	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
BG558_RS13025	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
BG558_RS13030	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BG558_RS13035	COG1053	succinate dehydrogenase
BG558_RS13040	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
BG558_RS13045	COG2962	Rard protein
BG558_RS13050	COG2223	nitrite transmembrane transporter activity
BG558_RS13055	COG2223	nitrite transmembrane transporter activity
BG558_RS13060	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BG558_RS13065	COG2020	methyltransferase activity
BG558_RS13070	COG0728	peptidoglycan biosynthetic process
BG558_RS13075	COG0268	Binds directly to 16S ribosomal RNA
BG558_RS13080	COG1970	mechanosensitive ion channel activity
BG558_RS13085	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
BG558_RS13090	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BG558_RS13095	COG1739	Uncharacterized protein family UPF0029
BG558_RS13105	COG1119	ATPase activity
BG558_RS13115	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BG558_RS13120	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
BG558_RS13130	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BG558_RS13135	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
BG558_RS13140	COG0321	lipoyl(octanoyl) transferase activity
BG558_RS13145	COG2921	Belongs to the UPF0250 family
BG558_RS13150	COG1686	Belongs to the peptidase S11 family
BG558_RS13155	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
BG558_RS13160	COG0772	Belongs to the SEDS family
BG558_RS13165	COG0768	penicillin binding
BG558_RS13175	COG0799	negative regulation of ribosome biogenesis
BG558_RS13185	COG1312	Catalyzes the dehydration of D-mannonate
BG558_RS13190	COG2186	Transcriptional regulator
BG558_RS13195	COG1028	Short-chain dehydrogenase reductase Sdr
BG558_RS13210	COG2211	Major facilitator Superfamily
BG558_RS13225	COG0800	Aldolase
BG558_RS13230	COG4783	chaperone-mediated protein folding
BG558_RS13250	COG0545	Peptidyl-prolyl cis-trans isomerase
BG558_RS13255	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BG558_RS13270	COG0037	tRNA processing
BG558_RS13275	COG4974	Belongs to the 'phage' integrase family
BG558_RS13310	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BG558_RS13335	COG3133	Outer membrane lipoprotein
BG558_RS13340	COG3102	Protein conserved in bacteria
BG558_RS13345	COG0018	arginyl-trna synthetase
BG558_RS13350	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BG558_RS13360	COG1138	Cytochrome C-type biogenesis protein
BG558_RS13370	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BG558_RS13375	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BG558_RS13380	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BG558_RS13385	COG4133	protoheme IX ABC transporter activity
BG558_RS13390	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BG558_RS13395	COG0747	negative chemotaxis
BG558_RS13400	COG0601	transmembrane transport
BG558_RS13405	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BG558_RS13410	COG0444	Belongs to the ABC transporter superfamily
BG558_RS13415	COG4608	Belongs to the ABC transporter superfamily
BG558_RS13430	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BG558_RS13430	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BG558_RS13435	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BG558_RS13445	COG2801	Transposase and inactivated derivatives
BG558_RS13450	COG0616	signal peptide processing
BG558_RS13470	COG2801	Transposase and inactivated derivatives
BG558_RS13510	COG3161	chorismate lyase activity
BG558_RS13520	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
BG558_RS13535	COG0442	prolyl-tRNA aminoacylation
BG558_RS13560	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BG558_RS13570	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BG558_RS13575	COG1192	Involved in chromosome partitioning
BG558_RS13605	COG3676	manually curated
BG558_RS13635	COG3012	SEC-C Motif Domain Protein