locus-tag	class	description
BG586_RS00100	COG3392	D12 class N6 adenine-specific DNA methyltransferase
BG586_RS00105	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
BG586_RS00110	COG1757	Na H antiporter
BG586_RS00120	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BG586_RS00130	COG1160	GTP binding
BG586_RS00135	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
BG586_RS00135	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
BG586_RS00140	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
BG586_RS00145	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BG586_RS00150	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BG586_RS00155	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
BG586_RS00160	COG0318	PFAM AMP-dependent synthetase and ligase
BG586_RS00170	COG3026	antisigma factor binding
BG586_RS00175	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
BG586_RS00180	COG1595	DNA-templated transcription, initiation
BG586_RS00190	COG0561	phosphatase activity
BG586_RS00195	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BG586_RS00205	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
BG586_RS00220	COG1074	ATP-dependent DNA helicase activity
BG586_RS00225	COG0534	Mate efflux family protein
BG586_RS00230	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
BG586_RS00250	COG1643	Atp-dependent helicase
BG586_RS00265	COG0330	HflC and HflK could
BG586_RS00270	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
BG586_RS00280	COG2932	Transcriptional regulator
BG586_RS00285	COG0791	NLP P60 protein
BG586_RS00295	COG3381	protein complex oligomerization
BG586_RS00315	COG0815	Transfers the fatty acyl group on membrane lipoproteins
BG586_RS00340	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
BG586_RS00345	COG0583	DNA-binding transcription factor activity
BG586_RS00370	COG1702	phosphate starvation-inducible protein PhoH
BG586_RS00385	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
BG586_RS00390	COG0626	cystathionine gamma-synthase activity
BG586_RS00405	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
BG586_RS00410	COG3023	N-Acetylmuramoyl-L-alanine amidase
BG586_RS00415	COG0564	pseudouridine synthase activity
BG586_RS00440	COG0232	Belongs to the dGTPase family. Type 2 subfamily
BG586_RS00445	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BG586_RS00450	COG2814	Major facilitator Superfamily
BG586_RS00460	COG1441	menaquinone biosynthetic process
BG586_RS00475	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BG586_RS00480	COG2027	D-alanyl-D-alanine carboxypeptidase
BG586_RS00495	COG1760	l-serine dehydratase
BG586_RS00500	COG0814	amino acid
BG586_RS00505	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BG586_RS00510	COG1560	Kdo2-lipid A biosynthetic process
BG586_RS00515	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
BG586_RS00525	COG0564	pseudouridine synthase activity
BG586_RS00530	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BG586_RS00545	COG1965	Belongs to the frataxin family
BG586_RS00555	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BG586_RS00560	COG0291	Belongs to the bacterial ribosomal protein bL35 family
BG586_RS00565	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
BG586_RS00580	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BG586_RS00585	COG0670	Belongs to the BI1 family
BG586_RS00590	COG2920	part of a sulfur-relay system
BG586_RS00605	COG2190	(PTS) system
BG586_RS00605	COG1263	PTS System
BG586_RS00605	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BG586_RS00620	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BG586_RS00625	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BG586_RS00635	COG1584	GPR1 FUN34 yaaH family protein
BG586_RS00655	COG0861	Integral membrane protein TerC family
BG586_RS00660	COG1472	Belongs to the glycosyl hydrolase 3 family
BG586_RS00665	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BG586_RS00670	COG0148	phosphopyruvate hydratase activity
BG586_RS00675	COG4316	Uncharacterized protein conserved in bacteria (DUF2251)
BG586_RS00685	COG2233	PERMEase
BG586_RS00690	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BG586_RS00710	COG2801	Transposase and inactivated derivatives
BG586_RS00715	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BG586_RS00750	COG1408	metallophosphoesterase
BG586_RS00755	COG3739	integral membrane protein
BG586_RS00760	COG1085	galactose-1-phosphate uridylyltransferase
BG586_RS00765	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
BG586_RS00770	COG2017	converts alpha-aldose to the beta-anomer
BG586_RS00775	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
BG586_RS00780	COG1862	Preprotein translocase
BG586_RS00785	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BG586_RS00790	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BG586_RS00795	COG2252	PERMEase
BG586_RS00810	COG1840	ABC-type Fe3 transport system, periplasmic component
BG586_RS00815	COG1252	NADH dehydrogenase
BG586_RS00825	COG3719	Belongs to the RNase T2 family
BG586_RS00835	COG4667	esterase of the alpha-beta hydrolase superfamily
BG586_RS00865	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BG586_RS00870	COG3593	DNA synthesis involved in DNA repair
BG586_RS00875	COG1611	Belongs to the LOG family
BG586_RS00880	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
BG586_RS00885	COG0488	(ABC) transporter
BG586_RS00890	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BG586_RS00900	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BG586_RS00955	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
BG586_RS00960	COG1538	Outer membrane efflux protein
BG586_RS00965	COG0194	GDP metabolic process
BG586_RS00970	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
BG586_RS00985	COG2195	Cleaves the N-terminal amino acid of tripeptides
BG586_RS00995	COG2914	Belongs to the UPF0125 (RnfH) family
BG586_RS01000	COG2867	negative regulation of translational initiation
BG586_RS01005	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
BG586_RS01010	COG4149	molybdate abc transporter
BG586_RS01015	COG0725	ABC transporter, periplasmic molybdate-binding protein
BG586_RS01020	COG0842	Transport permease protein
BG586_RS01025	COG1131	(ABC) transporter
BG586_RS01030	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
BG586_RS01035	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BG586_RS01040	COG1560	Kdo2-lipid A biosynthetic process
BG586_RS01060	COG4658	electron transport chain
BG586_RS01065	COG2860	membrane
BG586_RS01070	COG4656	Part of a membrane complex involved in electron transport
BG586_RS01075	COG2878	Part of a membrane complex involved in electron transport
BG586_RS01080	COG4657	Part of a membrane complex involved in electron transport
BG586_RS01105	COG0488	(ABC) transporter
BG586_RS01125	COG2965	DNA replication, synthesis of RNA primer
BG586_RS01145	COG1640	4-alpha-glucanotransferase
BG586_RS01160	COG3273	potassium ion transport
BG586_RS01160	COG0471	metal ion transport
BG586_RS01165	COG1187	pseudouridine synthase activity
BG586_RS01170	COG0009	L-threonylcarbamoyladenylate synthase
BG586_RS01175	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BG586_RS01180	COG0512	Glutamine amidotransferase of anthranilate synthase
BG586_RS01185	COG1942	4-Oxalocrotonate Tautomerase
BG586_RS01195	COG2226	methyltransferase
BG586_RS01205	COG2166	iron-sulfur cluster assembly
BG586_RS01210	COG0740	serine-type endopeptidase activity
BG586_RS01215	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
BG586_RS01240	COG1663	tetraacyldisaccharide 4'-kinase activity
BG586_RS01260	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
BG586_RS01265	COG4206	TonB-dependent receptor
BG586_RS01280	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BG586_RS01285	COG1120	ATPase activity
BG586_RS01315	COG2814	Major facilitator Superfamily
BG586_RS01320	COG1120	ATPase activity
BG586_RS01335	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BG586_RS01345	COG4773	Receptor
BG586_RS01355	COG2268	Band 7 protein
BG586_RS01360	COG2841	Protein conserved in bacteria
BG586_RS01365	COG1605	Chorismate mutase
BG586_RS01365	COG0077	Prephenate dehydratase
BG586_RS01370	COG0339	signal peptide processing
BG586_RS01375	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
BG586_RS01385	COG1882	Formate acetyltransferase
BG586_RS01390	COG2116	formate transmembrane transporter activity
BG586_RS01395	COG1238	metal cluster binding
BG586_RS01400	COG0501	Belongs to the peptidase M48B family
BG586_RS01410	COG2431	L-lysine efflux transmembrane transporter activity
BG586_RS01425	COG3392	D12 class N6 adenine-specific DNA methyltransferase
BG586_RS01550	COG5005	Phage virion morphogenesis
BG586_RS01570	COG4373	Mu-like prophage FluMu protein gp28
BG586_RS01580	COG0640	Transcriptional regulator
BG586_RS01615	COG4382	Mu-like prophage protein Gp16
BG586_RS01655	COG2842	Transposition protein
BG586_RS01665	COG2801	Transposase and inactivated derivatives
BG586_RS01670	COG3423	Transcriptional regulator
BG586_RS01695	COG0494	nUDIX hydrolase
BG586_RS01710	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
BG586_RS01715	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BG586_RS01720	COG5007	Belongs to the BolA IbaG family
BG586_RS01730	COG2854	intermembrane phospholipid transfer
BG586_RS01735	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
BG586_RS01740	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BG586_RS01745	COG1127	ABC transporter
BG586_RS01750	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BG586_RS01760	COG4235	cytochrome complex assembly
BG586_RS01760	COG3088	subunit of a heme lyase
BG586_RS01765	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BG586_RS01770	COG1138	Cytochrome C-type biogenesis protein
BG586_RS01775	COG3301	Polysulphide reductase, NrfD
BG586_RS01780	COG0437	4 iron, 4 sulfur cluster binding
BG586_RS01785	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
BG586_RS01800	COG3978	acetolactate synthase activity
BG586_RS01820	COG0477	Major facilitator Superfamily
BG586_RS01845	COG0616	signal peptide processing
BG586_RS01850	COG0778	Nitroreductase
BG586_RS01855	COG2183	response to ionizing radiation
BG586_RS01860	COG3063	Type IV pilus biogenesis stability protein PilW
BG586_RS01885	COG1121	(ABC) transporter
BG586_RS01890	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BG586_RS01895	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BG586_RS01900	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BG586_RS01930	COG2195	Cleaves the N-terminal amino acid of tripeptides
BG586_RS01935	COG1487	ribonuclease activity
BG586_RS01955	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BG586_RS01960	COG0814	amino acid
BG586_RS01975	COG0748	coenzyme F420 binding
BG586_RS01980	COG0308	aminopeptidase N
BG586_RS01985	COG1254	Belongs to the acylphosphatase family
BG586_RS01990	COG4166	transmembrane transport
BG586_RS02010	COG5413	integral membrane protein
BG586_RS02015	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BG586_RS02025	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BG586_RS02040	COG1187	pseudouridine synthase activity
BG586_RS02050	COG3030	protein affecting phage T7 exclusion by the F plasmid
BG586_RS02055	COG0006	proline dipeptidase activity
BG586_RS02065	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
BG586_RS02110	COG1793	dna ligase
BG586_RS02115	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
BG586_RS02120	COG1984	allophanate hydrolase subunit 2
BG586_RS02125	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
BG586_RS02130	COG1914	H( )-stimulated, divalent metal cation uptake system
BG586_RS02135	COG3630	sodium ion export across plasma membrane
BG586_RS02140	COG0511	ligase activity, forming carbon-carbon bonds
BG586_RS02140	COG5016	pyruvate
BG586_RS02145	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
BG586_RS02150	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BG586_RS02160	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
BG586_RS02175	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
BG586_RS02185	COG2197	response regulator
BG586_RS02190	COG1609	Transcriptional regulator
BG586_RS02195	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BG586_RS02200	COG1879	ABC-type sugar transport system periplasmic component
BG586_RS02205	COG1172	Belongs to the binding-protein-dependent transport system permease family
BG586_RS02210	COG1129	ABC transporter
BG586_RS02220	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
BG586_RS02225	COG0354	folic acid binding
BG586_RS02230	COG1561	YicC-like family, N-terminal region
BG586_RS02245	COG1556	Lactate utilization protein
BG586_RS02250	COG1139	Iron-sulfur cluster binding protein
BG586_RS02255	COG0247	lactate metabolic process
BG586_RS02260	COG1620	l-lactate permease
BG586_RS02275	COG1686	Belongs to the peptidase S11 family
BG586_RS02285	COG0747	negative chemotaxis
BG586_RS02290	COG0601	transmembrane transport
BG586_RS02295	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BG586_RS02300	COG4172	Belongs to the ABC transporter superfamily
BG586_RS02305	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BG586_RS02310	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BG586_RS02325	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
BG586_RS02330	COG0196	riboflavin kinase activity
BG586_RS02335	COG3172	ATPase kinase involved in NAD metabolism
BG586_RS02340	COG2129	metallophosphoesterase
BG586_RS02345	COG0745	RESPONSE REGULATOR receiver
BG586_RS02355	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BG586_RS02360	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
BG586_RS02365	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BG586_RS02375	COG1047	Peptidyl-prolyl cis-trans
BG586_RS02380	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BG586_RS02390	COG1720	tRNA m6t6A37 methyltransferase activity
BG586_RS02395	COG1575	Belongs to the MenA family. Type 1 subfamily
BG586_RS02405	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BG586_RS02425	COG3307	-O-antigen
BG586_RS02430	COG1088	dTDP-glucose 4,6-dehydratase activity
BG586_RS02440	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BG586_RS02450	COG1216	Glycosyl transferase, family 2
BG586_RS02465	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
BG586_RS02475	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
BG586_RS02480	COG0594	ribonuclease P activity
BG586_RS02485	COG0230	Belongs to the bacterial ribosomal protein bL34 family
BG586_RS02500	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BG586_RS02505	COG1758	RNA polymerase activity
BG586_RS02520	COG1621	beta-fructofuranosidase activity
BG586_RS02525	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BG586_RS02530	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BG586_RS02535	COG2190	(PTS) system
BG586_RS02540	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BG586_RS02545	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BG586_RS02550	COG1178	ABC-type Fe3 transport system permease component
BG586_RS02555	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
BG586_RS02565	COG0024	Methionine aminopeptidase
BG586_RS02570	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
BG586_RS02580	COG0676	glucose-6-phosphate 1-epimerase activity
BG586_RS02585	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
BG586_RS02600	COG3084	Protein conserved in bacteria
BG586_RS02605	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BG586_RS02610	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BG586_RS02615	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BG586_RS02620	COG3691	Protein conserved in bacteria
BG586_RS02625	COG0513	Belongs to the DEAD box helicase family
BG586_RS02630	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
BG586_RS02640	COG0733	neurotransmitter:sodium symporter activity
BG586_RS02645	COG4536	flavin adenine dinucleotide binding
BG586_RS02650	COG4137	Cytochrome C assembly protein
BG586_RS02655	COG1399	metal-binding, possibly nucleic acid-binding protein
BG586_RS02665	COG0416	fatty acid biosynthetic process
BG586_RS02685	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
BG586_RS02690	COG2995	paraquat-inducible protein a
BG586_RS02705	COG1289	transmembrane transporter activity
BG586_RS02710	COG1803	Methylglyoxal synthase
BG586_RS02715	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
BG586_RS02720	COG0678	peroxiredoxin activity
BG586_RS02720	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
BG586_RS02725	COG0583	DNA-binding transcription factor activity
BG586_RS02730	COG1309	transcriptional regulator
BG586_RS02760	COG1858	cytochrome C peroxidase
BG586_RS02770	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BG586_RS02775	COG2853	Lipoprotein
BG586_RS02780	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
BG586_RS02785	COG3924	membrane
BG586_RS02790	COG4145	pantothenate transmembrane transporter activity
BG586_RS02795	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
BG586_RS02815	COG0494	nUDIX hydrolase
BG586_RS02820	COG2801	Transposase and inactivated derivatives
BG586_RS02845	COG3381	protein complex oligomerization
BG586_RS02855	COG3005	denitrification pathway
BG586_RS02865	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
BG586_RS02870	COG3005	denitrification pathway
BG586_RS02875	COG3043	anaerobic respiration
BG586_RS02880	COG0348	domain, Protein
BG586_RS02885	COG0437	4 iron, 4 sulfur cluster binding
BG586_RS02890	COG0243	molybdopterin cofactor binding
BG586_RS02895	COG3062	negative regulation of establishment of protein localization
BG586_RS02900	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
BG586_RS02905	COG2249	NAD(P)H dehydrogenase (quinone) activity
BG586_RS02910	COG3111	PFAM Bacterial OB fold (BOF) protein
BG586_RS02915	COG0076	glutamate decarboxylase activity
BG586_RS02920	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
BG586_RS02925	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
BG586_RS02935	COG3395	kinase activity
BG586_RS02940	COG1349	DNA-binding transcription factor activity
BG586_RS02955	COG2003	Belongs to the UPF0758 family
BG586_RS02960	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BG586_RS02985	COG1309	transcriptional regulator
BG586_RS03000	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BG586_RS03005	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
BG586_RS03005	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
BG586_RS03030	COG0747	negative chemotaxis
BG586_RS03040	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
BG586_RS03055	COG4795	General secretion pathway protein
BG586_RS03080	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BG586_RS03085	COG1757	Na H antiporter
BG586_RS03095	COG3676	manually curated
BG586_RS03100	COG0747	negative chemotaxis
BG586_RS03105	COG4211	Belongs to the binding-protein-dependent transport system permease family
BG586_RS03115	COG1879	ABC-type sugar transport system periplasmic component
BG586_RS03120	COG0675	Transposase, IS605 OrfB family
BG586_RS03130	COG1879	ABC-type sugar transport system periplasmic component
BG586_RS03140	COG3691	Protein conserved in bacteria
BG586_RS03145	COG1442	glycosyl transferase family 8
BG586_RS03160	COG2267	carboxylic ester hydrolase activity
BG586_RS03200	COG2801	Transposase and inactivated derivatives
BG586_RS03210	COG1475	DNA binding
BG586_RS03245	COG0210	DNA helicase
BG586_RS03255	COG0606	chelatase, subunit chli
BG586_RS03265	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BG586_RS03270	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
BG586_RS03280	COG1876	peptidase activity
BG586_RS03295	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
BG586_RS03305	COG0511	ligase activity, forming carbon-carbon bonds
BG586_RS03310	COG0439	Biotin carboxylase
BG586_RS03315	COG2850	peptidyl-arginine hydroxylation
BG586_RS03320	COG1694	Mazg nucleotide pyrophosphohydrolase
BG586_RS03340	COG0336	Belongs to the RNA methyltransferase TrmD family
BG586_RS03350	COG0228	four-way junction DNA binding
BG586_RS03355	COG2190	(PTS) system
BG586_RS03355	COG1263	PTS System
BG586_RS03355	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BG586_RS03365	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BG586_RS03380	COG3962	Belongs to the TPP enzyme family
BG586_RS03390	COG0673	inositol 2-dehydrogenase activity
BG586_RS03405	COG0673	inositol 2-dehydrogenase activity
BG586_RS03410	COG1172	Belongs to the binding-protein-dependent transport system permease family
BG586_RS03415	COG1129	ABC transporter
BG586_RS03430	COG3718	enzyme involved in inositol metabolism
BG586_RS03435	COG1012	belongs to the aldehyde dehydrogenase family
BG586_RS03440	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
BG586_RS03450	COG0583	DNA-binding transcription factor activity
BG586_RS03455	COG2610	gluconate transmembrane transporter activity
BG586_RS03460	COG3265	gluconokinase activity
BG586_RS03465	COG1609	Transcriptional regulator
BG586_RS03470	COG2207	Transcriptional regulator
BG586_RS03470	COG1609	Transcriptional regulator
BG586_RS03475	COG0203	ribosomal protein L17
BG586_RS03480	COG0202	RNA polymerase activity
BG586_RS03485	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BG586_RS03495	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
BG586_RS03505	COG0201	protein transport
BG586_RS03510	COG0200	Binds to the 23S rRNA
BG586_RS03520	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
BG586_RS03530	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
BG586_RS03540	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BG586_RS03560	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BG586_RS03565	COG1349	DNA-binding transcription factor activity
BG586_RS03575	COG1840	ABC-type Fe3 transport system, periplasmic component
BG586_RS03625	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BG586_RS03645	COG0521	Mo-molybdopterin cofactor biosynthetic process
BG586_RS03655	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BG586_RS03665	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
BG586_RS03675	COG3085	chromosome segregation
BG586_RS03695	COG2832	Protein of unknown function (DUF454)
BG586_RS03710	COG2964	Protein conserved in bacteria
BG586_RS03715	COG0814	amino acid
BG586_RS03735	COG4804	nuclease activity
BG586_RS03740	COG4545	Glutaredoxin-related protein
BG586_RS03765	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
BG586_RS03775	COG2610	gluconate transmembrane transporter activity
BG586_RS03780	COG3622	Belongs to the hyi family
BG586_RS03785	COG0235	Class ii aldolase
BG586_RS03790	COG3395	kinase activity
BG586_RS03795	COG2084	Dehydrogenase
BG586_RS03800	COG1349	DNA-binding transcription factor activity
BG586_RS03805	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BG586_RS03830	COG0741	lytic transglycosylase activity
BG586_RS03835	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
BG586_RS03840	COG1194	a g-specific adenine glycosylase
BG586_RS03845	COG0346	lactoylglutathione lyase activity
BG586_RS03850	COG0697	spore germination
BG586_RS03910	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BG586_RS03925	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
BG586_RS03930	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BG586_RS03935	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BG586_RS03940	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
BG586_RS03950	COG3545	Serine hydrolase
BG586_RS03960	COG1070	Carbohydrate kinase
BG586_RS03965	COG2115	Belongs to the xylose isomerase family
BG586_RS03970	COG4213	ABC transporter substrate-binding protein
BG586_RS03975	COG1129	ABC transporter
BG586_RS03980	COG4214	carbohydrate transport
BG586_RS03985	COG2801	Transposase and inactivated derivatives
BG586_RS03990	COG3423	Transcriptional regulator
BG586_RS03995	COG1396	sequence-specific DNA binding
BG586_RS04005	COG0471	metal ion transport
BG586_RS04005	COG0490	domain, Protein
BG586_RS04010	COG3722	fumarate hydratase activity
BG586_RS04030	COG0517	IMP dehydrogenase activity
BG586_RS04030	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
BG586_RS04035	COG1349	DNA-binding transcription factor activity
BG586_RS04040	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BG586_RS04045	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
BG586_RS04050	COG1028	Short-chain dehydrogenase reductase Sdr
BG586_RS04065	COG3730	PTS system glucitol sorbitol-specific
BG586_RS04070	COG2608	mercury ion transmembrane transporter activity
BG586_RS04080	COG1305	Transglutaminase-like
BG586_RS04085	COG0673	inositol 2-dehydrogenase activity
BG586_RS04100	COG1595	DNA-templated transcription, initiation
BG586_RS04105	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
BG586_RS04115	COG3676	manually curated
BG586_RS04135	COG4206	TonB-dependent receptor
BG586_RS04135	COG1629	transport
BG586_RS04170	COG1349	DNA-binding transcription factor activity
BG586_RS04175	COG2407	Converts the aldose L-fucose into the corresponding ketose L-fuculose
BG586_RS04180	COG1070	Carbohydrate kinase
BG586_RS04185	COG4154	Belongs to the RbsD FucU family
BG586_RS04190	COG0235	Class ii aldolase
BG586_RS04195	COG1129	ABC transporter
BG586_RS04200	COG1172	Belongs to the binding-protein-dependent transport system permease family
BG586_RS04205	COG1879	ABC-type sugar transport system periplasmic component
BG586_RS04210	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BG586_RS04210	COG1263	PTS System
BG586_RS04215	COG1454	alcohol dehydrogenase
BG586_RS04220	COG1012	belongs to the aldehyde dehydrogenase family
BG586_RS04225	COG3477	response to acidic pH
BG586_RS04230	COG0569	domain protein
BG586_RS04235	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BG586_RS04250	COG2358	TRAP transporter, solute receptor (TAXI family
BG586_RS04255	COG3276	selenocysteine insertion sequence binding
BG586_RS04265	COG0259	pyridoxamine-phosphate oxidase activity
BG586_RS04280	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
BG586_RS04305	COG2932	Transcriptional regulator
BG586_RS04310	COG3423	Transcriptional regulator
BG586_RS04315	COG2801	Transposase and inactivated derivatives
BG586_RS04350	COG5301	cellulose 1,4-beta-cellobiosidase activity
BG586_RS04360	COG0747	negative chemotaxis
BG586_RS04365	COG0716	FMN binding
BG586_RS04375	COG1522	sequence-specific DNA binding
BG586_RS04380	COG2502	aspartate--ammonia ligase
BG586_RS04405	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BG586_RS04410	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BG586_RS04445	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
BG586_RS04450	COG2731	YhcH YjgK YiaL family protein
BG586_RS04455	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
BG586_RS04460	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BG586_RS04465	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BG586_RS04470	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BG586_RS04475	COG1129	ABC transporter
BG586_RS04520	COG2271	Major facilitator Superfamily
BG586_RS04525	COG0584	glycerophosphoryl diester phosphodiesterase
BG586_RS04530	COG2271	Major facilitator Superfamily
BG586_RS04535	COG0667	Aldo Keto reductase
BG586_RS04545	COG2211	Major facilitator Superfamily
BG586_RS04550	COG0357	Ribosomal RNA small subunit methyltransferase G
BG586_RS04560	COG0445	tRNA wobble uridine modification
BG586_RS04565	COG3012	SEC-C Motif Domain Protein
BG586_RS04615	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
BG586_RS04620	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
BG586_RS04635	COG1192	Involved in chromosome partitioning
BG586_RS04640	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BG586_RS04650	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BG586_RS04670	COG0442	prolyl-tRNA aminoacylation
BG586_RS04685	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
BG586_RS04695	COG3161	chorismate lyase activity
BG586_RS04745	COG4974	Belongs to the 'phage' integrase family
BG586_RS04750	COG0037	tRNA processing
BG586_RS04760	COG3676	manually curated
BG586_RS04770	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BG586_RS04775	COG0545	Peptidyl-prolyl cis-trans isomerase
BG586_RS04795	COG4783	chaperone-mediated protein folding
BG586_RS04800	COG0800	Aldolase
BG586_RS04805	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BG586_RS04810	COG1028	Short-chain dehydrogenase reductase Sdr
BG586_RS04815	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BG586_RS04820	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
BG586_RS04825	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BG586_RS04830	COG1063	alcohol dehydrogenase
BG586_RS04835	COG2186	Transcriptional regulator
BG586_RS04840	COG1312	Catalyzes the dehydration of D-mannonate
BG586_RS04850	COG0799	negative regulation of ribosome biogenesis
BG586_RS04860	COG0768	penicillin binding
BG586_RS04865	COG0772	Belongs to the SEDS family
BG586_RS04870	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
BG586_RS04875	COG1686	Belongs to the peptidase S11 family
BG586_RS04880	COG2921	Belongs to the UPF0250 family
BG586_RS04885	COG0321	lipoyl(octanoyl) transferase activity
BG586_RS04890	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
BG586_RS04895	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BG586_RS04900	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
BG586_RS04905	COG2801	Transposase and inactivated derivatives
BG586_RS04915	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BG586_RS04925	COG1119	ATPase activity
BG586_RS04935	COG1739	Uncharacterized protein family UPF0029
BG586_RS04940	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BG586_RS04945	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
BG586_RS04950	COG1970	mechanosensitive ion channel activity
BG586_RS04955	COG0268	Binds directly to 16S ribosomal RNA
BG586_RS04960	COG0728	peptidoglycan biosynthetic process
BG586_RS04965	COG2020	methyltransferase activity
BG586_RS04970	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BG586_RS04980	COG2223	nitrite transmembrane transporter activity
BG586_RS04985	COG2962	Rard protein
BG586_RS04990	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
BG586_RS04995	COG1053	succinate dehydrogenase
BG586_RS05000	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BG586_RS05005	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
BG586_RS05010	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
BG586_RS05050	COG2264	protein methyltransferase activity
BG586_RS05060	COG0625	glutathione transferase activity
BG586_RS05065	COG0019	diaminopimelate decarboxylase activity
BG586_RS05080	COG3070	regulator of competence-specific genes
BG586_RS05085	COG0051	transcription antitermination factor activity, RNA binding
BG586_RS05090	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BG586_RS05095	COG0088	Forms part of the polypeptide exit tunnel
BG586_RS05100	COG0089	rRNA binding
BG586_RS05110	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
BG586_RS05120	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
BG586_RS05145	COG0840	transmembrane signaling receptor activity
BG586_RS05165	COG3835	regulator
BG586_RS05170	COG2610	gluconate transmembrane transporter activity
BG586_RS05175	COG1929	Belongs to the glycerate kinase type-1 family
BG586_RS05180	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
BG586_RS05200	COG0737	Belongs to the 5'-nucleotidase family
BG586_RS05220	COG3623	hexulose-6-phosphate isomerase
BG586_RS05225	COG0235	Class ii aldolase
BG586_RS05245	COG0825	malonyl-CoA metabolic process
BG586_RS05255	COG0204	Acyl-transferase
BG586_RS05270	COG2050	protein possibly involved in aromatic compounds catabolism
BG586_RS05275	COG0277	FAD linked oxidase domain protein
BG586_RS05275	COG0247	lactate metabolic process
BG586_RS05285	COG3120	sequence-specific DNA binding
BG586_RS05290	COG1067	ATP-dependent peptidase activity
BG586_RS05295	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BG586_RS05310	COG0758	DNA mediated transformation
BG586_RS05330	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BG586_RS05340	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BG586_RS05355	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BG586_RS05370	COG1028	Short-chain dehydrogenase reductase Sdr
BG586_RS05375	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BG586_RS05385	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BG586_RS05395	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BG586_RS05410	COG1328	CTP reductase activity
BG586_RS05415	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
BG586_RS05425	COG3914	O-linked N-acetylglucosamine transferase SPINDLY family
BG586_RS05440	COG2900	Belongs to the SlyX family
BG586_RS05445	COG0545	Peptidyl-prolyl cis-trans isomerase
BG586_RS05450	COG2964	Protein conserved in bacteria
BG586_RS05455	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
BG586_RS05465	COG2168	tRNA wobble position uridine thiolation
BG586_RS05480	COG0085	RNA polymerase activity
BG586_RS05500	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BG586_RS05510	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
BG586_RS05525	COG0174	glutamine synthetase
BG586_RS05540	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
BG586_RS05590	COG2801	Transposase and inactivated derivatives
BG586_RS05605	COG0616	signal peptide processing
BG586_RS05615	COG2801	Transposase and inactivated derivatives
BG586_RS05620	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BG586_RS05620	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BG586_RS05625	COG1595	DNA-templated transcription, initiation
BG586_RS05635	COG4608	Belongs to the ABC transporter superfamily
BG586_RS05640	COG0444	Belongs to the ABC transporter superfamily
BG586_RS05645	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BG586_RS05650	COG0601	transmembrane transport
BG586_RS05655	COG0747	negative chemotaxis
BG586_RS05660	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BG586_RS05665	COG4133	protoheme IX ABC transporter activity
BG586_RS05670	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BG586_RS05675	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BG586_RS05680	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BG586_RS05690	COG1138	Cytochrome C-type biogenesis protein
BG586_RS05700	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BG586_RS05705	COG0018	arginyl-trna synthetase
BG586_RS05710	COG3102	Protein conserved in bacteria
BG586_RS05715	COG3133	Outer membrane lipoprotein
BG586_RS05740	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BG586_RS05770	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BG586_RS05780	COG0084	hydrolase, TatD family'
BG586_RS05795	COG0470	DNA polymerase III
BG586_RS05800	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
BG586_RS05805	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BG586_RS05825	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
BG586_RS05830	COG0501	Belongs to the peptidase M48B family
BG586_RS05835	COG0180	Tryptophanyl-tRNA synthetase
BG586_RS05850	COG0546	phosphoglycolate phosphatase activity
BG586_RS05860	COG0730	response to heat
BG586_RS05865	COG0494	nUDIX hydrolase
BG586_RS05880	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
BG586_RS05885	COG1064	alcohol dehydrogenase
BG586_RS05890	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BG586_RS05925	COG3617	BRO family, N-terminal domain
BG586_RS05975	COG3723	Recombinational DNA repair protein, rece pathway
BG586_RS06105	COG3179	chitinase
BG586_RS06140	COG0740	serine-type endopeptidase activity
BG586_RS06245	COG0778	Nitroreductase
BG586_RS06250	COG1902	pentaerythritol trinitrate reductase activity
BG586_RS06260	COG0431	NADPH-dependent FMN reductase
BG586_RS06270	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
BG586_RS06275	COG0668	transmembrane transport
BG586_RS06280	COG0564	pseudouridine synthase activity
BG586_RS06290	COG1393	Belongs to the ArsC family
BG586_RS06295	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BG586_RS06305	COG2391	methyltransferase activity
BG586_RS06310	COG0425	Belongs to the sulfur carrier protein TusA family
BG586_RS06315	COG0753	catalase activity
BG586_RS06335	COG0347	Belongs to the P(II) protein family
BG586_RS06355	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BG586_RS06370	COG3077	Addiction module antitoxin, RelB DinJ family
BG586_RS06375	COG3041	Addiction module toxin RelE StbE family
BG586_RS06390	COG1295	ribonuclease BN
BG586_RS06395	COG1490	D-aminoacyl-tRNA deacylase activity
BG586_RS06405	COG1114	Component of the transport system for branched-chain amino acids
BG586_RS06410	COG1028	Short-chain dehydrogenase reductase Sdr
BG586_RS06420	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
BG586_RS06425	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BG586_RS06430	COG0142	geranyltranstransferase activity
BG586_RS06435	COG0261	This protein binds to 23S rRNA in the presence of protein L20
BG586_RS06445	COG0697	spore germination
BG586_RS06450	COG0697	spore germination
BG586_RS06455	COG0561	phosphatase activity
BG586_RS06460	COG1040	competence protein
BG586_RS06465	COG2259	Doxx family
BG586_RS06470	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
BG586_RS06480	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
BG586_RS06490	COG0783	Belongs to the Dps family
BG586_RS06495	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BG586_RS06500	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
BG586_RS06515	COG0598	Magnesium transport protein CorA
BG586_RS06520	COG2226	methyltransferase
BG586_RS06525	COG3165	ubiquinone biosynthetic process from chorismate
BG586_RS06530	COG4804	nuclease activity
BG586_RS06535	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BG586_RS06540	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BG586_RS06545	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BG586_RS06550	COG0805	protein transport
BG586_RS06560	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BG586_RS06565	COG0220	tRNA (guanine-N7-)-methyltransferase activity
BG586_RS06570	COG3171	Protein conserved in bacteria
BG586_RS06580	COG0762	integral membrane protein
BG586_RS06585	COG1126	abc transporter atp-binding protein
BG586_RS06590	COG0765	amino acid transport
BG586_RS06595	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BG586_RS06600	COG0257	Belongs to the bacterial ribosomal protein bL36 family
BG586_RS06610	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BG586_RS06620	COG2818	Glycosylase
BG586_RS06630	COG4942	peptidase
BG586_RS06630	COG1388	LysM domain
BG586_RS06645	COG1238	metal cluster binding
BG586_RS06650	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
BG586_RS06670	COG3716	PTS system mannose fructose sorbose family IID component
BG586_RS06675	COG3715	PTS system
BG586_RS06680	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BG586_RS06680	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
BG586_RS06695	COG4974	Belongs to the 'phage' integrase family
BG586_RS06720	COG0688	phosphatidylethanolamine metabolic process
BG586_RS06725	COG1555	photosystem II stabilization
BG586_RS06730	COG3266	domain, Protein
BG586_RS06730	COG3061	Opacity-associated protein A
BG586_RS06740	COG0859	PFAM glycosyl transferase family 9
BG586_RS06745	COG0859	PFAM glycosyl transferase family 9
BG586_RS06750	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BG586_RS06755	COG0049	tRNA binding
BG586_RS06760	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BG586_RS06770	COG0544	peptidyl-prolyl cis-trans isomerase activity
BG586_RS06775	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BG586_RS06780	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
BG586_RS06785	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
BG586_RS06790	COG1045	serine acetyltransferase
BG586_RS06800	COG3728	DNA packaging
BG586_RS06825	COG0582	viral genome integration into host DNA
BG586_RS06835	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BG586_RS06860	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
BG586_RS06870	COG1217	gtp-binding protein TYPA
BG586_RS06875	COG0456	acetyltransferase
BG586_RS06880	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
BG586_RS06905	COG0131	Imidazoleglycerol-phosphate dehydratase
BG586_RS06905	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
BG586_RS06920	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
BG586_RS06935	COG0107	imidazoleglycerol-phosphate synthase activity
BG586_RS06955	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
BG586_RS06960	COG0494	nUDIX hydrolase
BG586_RS06965	COG1218	3'(2'),5'-bisphosphate nucleotidase
BG586_RS06970	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BG586_RS06975	COG0363	glucosamine-6-phosphate deaminase activity
BG586_RS06985	COG1794	racemase activity, acting on amino acids and derivatives
BG586_RS06990	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
BG586_RS07000	COG0525	valine-tRNA ligase activity
BG586_RS07010	COG4185	zeta toxin
BG586_RS07020	COG2153	protein acetylation
BG586_RS07025	COG2927	DNA polymerase III (CHI subunit)
BG586_RS07030	COG1652	LysM domain
BG586_RS07095	COG0497	DNA recombination
BG586_RS07110	COG0849	cell division
BG586_RS07120	COG1181	Belongs to the D-alanine--D-alanine ligase family
BG586_RS07130	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BG586_RS07135	COG0772	Belongs to the SEDS family
BG586_RS07140	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BG586_RS07145	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BG586_RS07150	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BG586_RS07155	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BG586_RS07160	COG0768	penicillin binding
BG586_RS07165	COG3116	cell division
BG586_RS07185	COG0557	exoribonuclease II activity
BG586_RS07190	COG2824	Alkylphosphonate utilization operon protein PhnA
BG586_RS07195	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
BG586_RS07205	COG1917	Cupin 2, conserved barrel domain protein
BG586_RS07205	COG4977	sequence-specific DNA binding
BG586_RS07215	COG1530	ribonuclease E activity
BG586_RS07230	COG3068	Protein conserved in bacteria
BG586_RS07245	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
BG586_RS07255	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BG586_RS07260	COG1414	Transcriptional regulator
BG586_RS07265	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BG586_RS07285	COG3107	peptidoglycan biosynthetic process
BG586_RS07290	COG0792	nuclease activity
BG586_RS07295	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
BG586_RS07325	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BG586_RS07335	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BG586_RS07340	COG2814	Major facilitator Superfamily
BG586_RS07350	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
BG586_RS07355	COG0793	Belongs to the peptidase S41A family
BG586_RS07360	COG2989	Protein conserved in bacteria
BG586_RS07365	COG3108	Peptidase M15
BG586_RS07370	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BG586_RS07380	COG0537	adenosine 5'-monophosphoramidase activity
BG586_RS07390	COG1162	GTPase activity
BG586_RS07395	COG0583	DNA-binding transcription factor activity
BG586_RS07400	COG1011	Hydrolase
BG586_RS07405	COG0583	DNA-binding transcription factor activity
BG586_RS07415	COG0252	asparaginase activity
BG586_RS07425	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
BG586_RS07425	COG0316	Belongs to the HesB IscA family
BG586_RS07435	COG1805	sodium ion transport
BG586_RS07440	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
BG586_RS07445	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
BG586_RS07450	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
BG586_RS07455	COG2871	sodium ion transport
BG586_RS07460	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
BG586_RS07465	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
BG586_RS07470	COG1477	protein flavinylation
BG586_RS07475	COG2991	Protein conserved in bacteria
BG586_RS07495	COG0165	Argininosuccinate lyase
BG586_RS07500	COG1426	Protein conserved in bacteria
BG586_RS07505	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
BG586_RS07515	COG2976	Protein conserved in bacteria
BG586_RS07520	COG0592	DNA-directed DNA polymerase activity
BG586_RS07525	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BG586_RS07530	COG1132	(ABC) transporter
BG586_RS07535	COG1854	S-ribosylhomocysteine lyase activity
BG586_RS07540	COG3008	intermembrane lipid transfer
BG586_RS07545	COG0735	belongs to the Fur family
BG586_RS07550	COG0716	FMN binding
BG586_RS07560	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BG586_RS07565	COG2252	PERMEase
BG586_RS07570	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
BG586_RS07575	COG2081	HI0933 family
BG586_RS07580	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
BG586_RS07590	COG0560	Phosphoserine phosphatase
BG586_RS07595	COG1666	GTP binding
BG586_RS07615	COG1090	epimerase
BG586_RS07620	COG0210	DNA helicase
BG586_RS07645	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BG586_RS07650	COG0009	L-threonylcarbamoyladenylate synthase
BG586_RS07655	COG0551	DNA topoisomerase type I activity
BG586_RS07665	COG2137	regulation of response to DNA damage stimulus
BG586_RS07675	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BG586_RS07685	COG1322	Protein conserved in bacteria
BG586_RS07685	COG1322	Protein conserved in bacteria
BG586_RS07690	COG0512	Glutamine amidotransferase of anthranilate synthase
BG586_RS07720	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BG586_RS07725	COG4591	ABC-type transport system involved in lipoprotein release permease component
BG586_RS07730	COG1136	(ABC) transporter
BG586_RS07735	COG4591	ABC-type transport system involved in lipoprotein release permease component
BG586_RS07760	COG0084	hydrolase, TatD family'
BG586_RS07765	COG1966	Carbon starvation protein
BG586_RS07770	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BG586_RS07775	COG0483	inositol monophosphate 1-phosphatase activity
BG586_RS07780	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BG586_RS07785	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BG586_RS07805	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BG586_RS07815	COG4206	TonB-dependent receptor
BG586_RS07815	COG1629	transport
BG586_RS07820	COG4206	TonB-dependent receptor
BG586_RS07820	COG1629	transport
BG586_RS07825	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
BG586_RS07830	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
BG586_RS07835	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BG586_RS07855	COG4172	Belongs to the ABC transporter superfamily
BG586_RS07860	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BG586_RS07865	COG0601	transmembrane transport
BG586_RS07870	COG1177	transmembrane transport
BG586_RS07875	COG1176	ABC-type spermidine putrescine transport system, permease component I
BG586_RS07880	COG3842	ATPase activity
BG586_RS07885	COG0210	DNA helicase
BG586_RS07890	COG1027	Aspartate ammonia-lyase
BG586_RS07895	COG3326	Membrane
BG586_RS07900	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
BG586_RS07910	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BG586_RS07915	COG3099	Belongs to the UPF0263 family
BG586_RS07920	COG0742	ribosomal rna small subunit methyltransferase
BG586_RS07925	COG0552	protein localization to endoplasmic reticulum
BG586_RS07930	COG2884	Cell division ATP-binding protein ftsE
BG586_RS07935	COG2177	Part of the ABC transporter FtsEX involved in
BG586_RS07955	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BG586_RS07965	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BG586_RS07970	COG1137	ATPase activity
BG586_RS07975	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
BG586_RS07980	COG3117	lipopolysaccharide transmembrane transporter activity
BG586_RS07985	COG0708	Exodeoxyribonuclease III
BG586_RS07990	COG2056	Na+-H+ antiporter family
BG586_RS08000	COG1640	4-alpha-glucanotransferase
BG586_RS08005	COG0058	SHG alpha-glucan phosphorylase activity
BG586_RS08010	COG2909	trisaccharide binding
BG586_RS08015	COG0366	Alpha amylase catalytic
BG586_RS08020	COG3833	ABC-type maltose transport systems, permease component
BG586_RS08025	COG1175	transmembrane transport
BG586_RS08035	COG3842	ATPase activity
BG586_RS08050	COG0475	glutathione-regulated potassium exporter activity
BG586_RS08050	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BG586_RS08060	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BG586_RS08080	COG3115	cell septum assembly
BG586_RS08110	COG3118	belongs to the thioredoxin family
BG586_RS08115	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BG586_RS08115	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BG586_RS08115	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
BG586_RS08120	COG1461	Dihydroxyacetone kinase
BG586_RS08125	COG2376	Dihydroxyacetone kinase
BG586_RS08130	COG0492	ferredoxin-NADP+ reductase activity
BG586_RS08140	COG3753	Protein conserved in bacteria
BG586_RS08145	COG0402	S-adenosylhomocysteine deaminase activity
BG586_RS08150	COG4143	(ABC) transporter
BG586_RS08155	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
BG586_RS08160	COG0617	tRNA 3'-terminal CCA addition
BG586_RS08165	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BG586_RS08175	COG2911	Protein conserved in bacteria
BG586_RS08190	COG0346	lactoylglutathione lyase activity
BG586_RS08205	COG4771	TonB-dependent receptor
BG586_RS08205	COG1629	transport
BG586_RS08215	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BG586_RS08220	COG2062	phosphohistidine phosphatase, SixA
BG586_RS08225	COG0469	pyruvate kinase activity
BG586_RS08230	COG0859	PFAM glycosyl transferase family 9
BG586_RS08235	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
BG586_RS08240	COG0287	Prephenate dehydrogenase
BG586_RS08240	COG1605	Chorismate mutase
BG586_RS08250	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
BG586_RS08255	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
BG586_RS08260	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
BG586_RS08265	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BG586_RS08275	COG0251	oxidation-reduction process
BG586_RS08280	COG1022	Amp-dependent synthetase and ligase
BG586_RS08285	COG3101	peptidyl-lysine hydroxylation
BG586_RS08290	COG4232	protein-disulfide reductase activity
BG586_RS08295	COG1126	abc transporter atp-binding protein
BG586_RS08300	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BG586_RS08305	COG4215	(ABC) transporter
BG586_RS08310	COG4160	amino acid transport
BG586_RS08315	COG2255	four-way junction helicase activity
BG586_RS08320	COG0632	four-way junction helicase activity
BG586_RS08325	COG1280	lysine exporter protein (LysE YggA)
BG586_RS08330	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
BG586_RS08335	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
BG586_RS08340	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BG586_RS08345	COG4796	Type ii and iii secretion system protein
BG586_RS08370	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
BG586_RS08380	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BG586_RS08385	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
BG586_RS08390	COG0338	D12 class N6 adenine-specific DNA methyltransferase
BG586_RS08395	COG0733	neurotransmitter:sodium symporter activity
BG586_RS08400	COG0126	phosphoglycerate kinase activity
BG586_RS08405	COG0191	fructose-bisphosphate aldolase activity
BG586_RS08410	COG4172	Belongs to the ABC transporter superfamily
BG586_RS08415	COG0778	Nitroreductase
BG586_RS08425	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BG586_RS08435	COG3058	Necessary for formate dehydrogenase activity
BG586_RS08440	COG2864	formate dehydrogenase
BG586_RS08445	COG0437	4 iron, 4 sulfur cluster binding
BG586_RS08465	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BG586_RS08470	COG0215	cysteine-tRNA ligase activity
BG586_RS08475	COG0083	homoserine kinase activity
BG586_RS08480	COG0460	homoserine dehydrogenase
BG586_RS08480	COG0527	aspartate kinase activity
BG586_RS08490	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BG586_RS08495	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BG586_RS08525	COG0166	Belongs to the GPI family
BG586_RS08530	COG2960	long-chain fatty acid transporting porin activity
BG586_RS08540	COG0720	synthase
BG586_RS08545	COG0602	queuosine metabolic process
BG586_RS08570	COG1169	isochorismate synthase
BG586_RS08575	COG0436	Aminotransferase
BG586_RS08580	COG2962	Rard protein
BG586_RS08585	COG1280	lysine exporter protein (LysE YggA)
BG586_RS08595	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BG586_RS08600	COG1434	Gram-negative-bacterium-type cell wall biogenesis
BG586_RS08610	COG2089	acid synthase
BG586_RS08625	COG2244	polysaccharide biosynthetic process
BG586_RS08635	COG3306	glycosyltransferase involved in LPS biosynthesis
BG586_RS08645	COG1216	Glycosyl transferase, family 2
BG586_RS08650	COG1216	Glycosyl transferase, family 2
BG586_RS08660	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BG586_RS08670	COG0813	purine-nucleoside phosphorylase activity
BG586_RS08675	COG2207	Transcriptional regulator
BG586_RS08680	COG1764	response to oxidative stress
BG586_RS08690	COG1902	pentaerythritol trinitrate reductase activity
BG586_RS08700	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
BG586_RS08710	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BG586_RS08715	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BG586_RS08715	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
BG586_RS08720	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BG586_RS08725	COG3715	PTS system
BG586_RS08730	COG3716	PTS system mannose fructose sorbose family IID component
BG586_RS08745	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BG586_RS08745	COG3711	transcriptional antiterminator
BG586_RS08760	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
BG586_RS08765	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BG586_RS08770	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BG586_RS08780	COG0795	lipopolysaccharide-transporting ATPase activity
BG586_RS08785	COG0795	lipopolysaccharide-transporting ATPase activity
BG586_RS08800	COG0826	peptidase U32
BG586_RS08805	COG1519	Transferase
BG586_RS08815	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
BG586_RS08820	COG0802	atpase or kinase
BG586_RS08825	COG1388	LysM domain
BG586_RS08825	COG0860	N-Acetylmuramoyl-L-alanine amidase
BG586_RS08835	COG0531	amino acid
BG586_RS08845	COG1454	alcohol dehydrogenase
BG586_RS08845	COG1012	belongs to the aldehyde dehydrogenase family
BG586_RS08850	COG0181	hydroxymethylbilane synthase activity
BG586_RS08860	COG2959	enzyme of heme biosynthesis
BG586_RS08865	COG3071	HemY protein
BG586_RS08870	COG2354	Protein conserved in bacteria
BG586_RS08875	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BG586_RS08880	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BG586_RS08885	COG2095	MarC family integral membrane protein
BG586_RS08890	COG4166	transmembrane transport
BG586_RS08895	COG0489	protein tyrosine kinase activity
BG586_RS08900	COG3642	lipopolysaccharide core region biosynthetic process
BG586_RS08905	COG0302	gtp cyclohydrolase
BG586_RS08920	COG2608	mercury ion transmembrane transporter activity
BG586_RS08925	COG0789	Transcriptional regulator
BG586_RS08940	COG0187	DNA topoisomerase II activity
BG586_RS08950	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
BG586_RS08960	COG0295	cytidine deaminase activity
BG586_RS08965	COG0471	metal ion transport
BG586_RS08970	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
BG586_RS08980	COG0542	response to heat
BG586_RS08995	COG0330	HflC and HflK could
BG586_RS09000	COG0330	HflC and HflK could
BG586_RS09070	COG3077	Addiction module antitoxin, RelB DinJ family
BG586_RS09185	COG0629	single-stranded DNA binding
BG586_RS09205	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BG586_RS09205	COG0301	tRNA thio-modification
BG586_RS09215	COG0205	6-phosphofructokinase activity
BG586_RS09220	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BG586_RS09280	COG1525	nuclease
BG586_RS09285	COG1115	amino acid carrier protein
BG586_RS09290	COG0628	permease
BG586_RS09300	COG1678	Uncharacterized ACR, COG1678
BG586_RS09305	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BG586_RS09320	COG0271	Belongs to the BolA IbaG family
BG586_RS09350	COG0494	nUDIX hydrolase
BG586_RS09360	COG2801	Transposase and inactivated derivatives
BG586_RS09385	COG1271	oxidase subunit
BG586_RS09390	COG1294	oxidase, subunit
BG586_RS09405	COG0824	Thioesterase
BG586_RS09410	COG0811	peptide transport
BG586_RS09415	COG0848	biopolymer transport protein
BG586_RS09420	COG3064	Membrane
BG586_RS09425	COG0823	Involved in the tonB-independent uptake of proteins
BG586_RS09440	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
BG586_RS09450	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BG586_RS09465	COG0564	pseudouridine synthase activity
BG586_RS09480	COG0488	(ABC) transporter
BG586_RS09490	COG2095	MarC family integral membrane protein
BG586_RS09495	COG0303	'Molybdopterin
BG586_RS09500	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BG586_RS09515	COG5301	cellulose 1,4-beta-cellobiosidase activity
BG586_RS09525	COG3299	homolog of phage Mu protein gp47
BG586_RS09595	COG4397	Mu-like prophage major head subunit gpT
BG586_RS09605	COG5005	Phage virion morphogenesis
BG586_RS09615	COG4383	Mu-like prophage protein gp29
BG586_RS09675	COG4382	Mu-like prophage protein Gp16
BG586_RS09720	COG2842	Transposition protein
BG586_RS09730	COG3423	Transcriptional regulator
BG586_RS09735	COG2932	Transcriptional regulator
BG586_RS09740	COG3092	negative regulation of chromosome organization
BG586_RS09750	COG2917	probably involved in intracellular septation
BG586_RS09755	COG1607	acyl-coa hydrolase
BG586_RS09760	COG2350	Protein conserved in bacteria
BG586_RS09770	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
BG586_RS09775	COG0732	type I restriction modification DNA specificity domain
BG586_RS09780	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
BG586_RS09800	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BG586_RS09805	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
BG586_RS09810	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
BG586_RS09830	COG3219	Protein conserved in bacteria
BG586_RS09845	COG2259	Doxx family
BG586_RS09850	COG2801	Transposase and inactivated derivatives
BG586_RS09870	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
BG586_RS09880	COG0681	Belongs to the peptidase S26 family
BG586_RS09890	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
BG586_RS09900	COG0513	Belongs to the DEAD box helicase family
BG586_RS09905	COG0433	COG0433 Predicted ATPase
BG586_RS09910	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
BG586_RS09915	COG3842	ATPase activity
BG586_RS09925	COG1840	ABC-type Fe3 transport system, periplasmic component
BG586_RS09940	COG2194	sulfuric ester hydrolase activity
BG586_RS09945	COG0528	UMP kinase activity
BG586_RS09950	COG0233	cytoplasmic translational termination
BG586_RS09960	COG4942	peptidase
BG586_RS09965	COG2861	carbohydrate metabolic process
BG586_RS09970	COG0729	surface antigen
BG586_RS09975	COG2911	Protein conserved in bacteria
BG586_RS09980	COG4988	ABC transporter
BG586_RS09985	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
BG586_RS09990	COG2915	High frequency lysogenization protein hflD homolog
BG586_RS09995	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BG586_RS10000	COG1349	DNA-binding transcription factor activity
BG586_RS10005	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
BG586_RS10025	COG0187	DNA topoisomerase II activity
BG586_RS10030	COG0500	methyltransferase
BG586_RS10035	COG1944	ATP diphosphatase activity
BG586_RS10055	COG0675	Transposase, IS605 OrfB family
BG586_RS10070	COG0582	viral genome integration into host DNA
BG586_RS10080	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BG586_RS10085	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BG586_RS10090	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
BG586_RS10100	COG3264	Mechanosensitive ion channel
BG586_RS10100	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
BG586_RS10105	COG0318	PFAM AMP-dependent synthetase and ligase
BG586_RS10115	COG0596	Alpha beta hydrolase
BG586_RS10120	COG2226	methyltransferase
BG586_RS10130	COG0586	Pfam SNARE associated Golgi protein
BG586_RS10140	COG0717	Belongs to the dCTP deaminase family
BG586_RS10145	COG0572	uridine kinase
BG586_RS10155	COG1077	Cell shape determining protein MreB Mrl
BG586_RS10160	COG1792	Involved in formation and maintenance of cell shape
BG586_RS10165	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
BG586_RS10170	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BG586_RS10175	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BG586_RS10180	COG0121	glutamine amidotransferase
BG586_RS10185	COG0142	geranyltranstransferase activity
BG586_RS10190	COG1722	exodeoxyribonuclease VII activity
BG586_RS10195	COG0633	Ferredoxin
BG586_RS10195	COG3217	Mosc domain protein beta barrel domain protein
BG586_RS10200	COG1368	sulfuric ester hydrolase activity
BG586_RS10215	COG0671	phosphoesterase, PA-phosphatase related
BG586_RS10220	COG1534	Rna-binding protein
BG586_RS10225	COG0463	Glycosyl transferase, family 2
BG586_RS10230	COG0859	PFAM glycosyl transferase family 9
BG586_RS10240	COG0328	RNA-DNA hybrid ribonuclease activity
BG586_RS10245	COG1286	toxin biosynthetic process
BG586_RS10260	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
BG586_RS10285	COG0305	Participates in initiation and elongation during chromosome replication
BG586_RS10315	COG0629	single-stranded DNA binding
BG586_RS10395	COG2132	Multicopper oxidase
BG586_RS10415	COG0667	Aldo Keto reductase
BG586_RS10435	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BG586_RS10750	COG4453	Protein conserved in bacteria
BG586_RS10830	COG2801	Transposase and inactivated derivatives
BG586_RS10835	COG0277	FAD linked oxidase domain protein
BG586_RS10845	COG2801	Transposase and inactivated derivatives
BG586_RS10860	COG0629	single-stranded DNA binding
BG586_RS10865	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BG586_RS10870	COG0659	secondary active sulfate transmembrane transporter activity
BG586_RS10880	COG1122	ATPase activity
BG586_RS10890	COG1199	ATP-dependent helicase activity
BG586_RS10900	COG1346	cytolysis
BG586_RS10905	COG1132	(ABC) transporter
BG586_RS10920	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BG586_RS10925	COG0167	dihydroorotate dehydrogenase activity
BG586_RS10930	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
BG586_RS10935	COG0508	dehydrogenase complex catalyzes the overall conversion of
BG586_RS10940	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BG586_RS10965	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BG586_RS10970	COG3676	manually curated
BG586_RS10975	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
BG586_RS10980	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BG586_RS11000	COG4991	sh3 domain protein
BG586_RS11005	COG0306	phosphate transporter
BG586_RS11010	COG1392	Phosphate transport regulator
BG586_RS11015	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
BG586_RS11030	COG4604	ABC transporter, ATP-binding protein
BG586_RS11040	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BG586_RS11045	COG4607	ABC-type enterochelin transport system periplasmic component
BG586_RS11050	COG0305	Participates in initiation and elongation during chromosome replication
BG586_RS11055	COG3100	YcgL domain-containing protein
BG586_RS11060	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
BG586_RS11070	COG0583	DNA-binding transcription factor activity
BG586_RS11090	COG0425	Belongs to the sulfur carrier protein TusA family
BG586_RS11105	COG1172	Belongs to the binding-protein-dependent transport system permease family
BG586_RS11110	COG1172	Belongs to the binding-protein-dependent transport system permease family
BG586_RS11130	COG0697	spore germination
BG586_RS11135	COG1278	Cold shock
BG586_RS11150	COG3945	hemerythrin HHE cation binding domain
BG586_RS11155	COG0425	Belongs to the sulfur carrier protein TusA family
BG586_RS11160	COG2932	Transcriptional regulator
BG586_RS11195	COG3787	Belongs to the UPF0306 family
BG586_RS11205	COG1811	Na channel or pump
BG586_RS11215	COG3028	Belongs to the UPF0307 family
BG586_RS11220	COG0312	modulator of DNA gyrase
BG586_RS11225	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
BG586_RS11230	COG4409	exo-alpha-(2->6)-sialidase activity
BG586_RS11330	COG0582	viral genome integration into host DNA
BG586_RS11340	COG1496	oxidoreductase activity
BG586_RS11345	COG0251	oxidation-reduction process
BG586_RS11355	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BG586_RS11360	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BG586_RS11370	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BG586_RS11390	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BG586_RS11400	COG1509	lysine 2,3-aminomutase activity
BG586_RS11405	COG0017	Asparaginyl-tRNA synthetase
BG586_RS11410	COG0582	viral genome integration into host DNA
BG586_RS11510	COG2801	Transposase and inactivated derivatives
BG586_RS11550	COG0305	Participates in initiation and elongation during chromosome replication
BG586_RS11620	COG3728	DNA packaging
BG586_RS11625	COG1783	phage Terminase large subunit
BG586_RS11685	COG1598	PFAM Uncharacterised protein family UPF0150
BG586_RS11690	COG1724	mRNA binding
BG586_RS11780	COG3683	transport system, periplasmic component
BG586_RS11785	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
BG586_RS11790	COG1115	amino acid carrier protein
BG586_RS11795	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
BG586_RS11800	COG0045	succinate-CoA ligase (ADP-forming) activity
BG586_RS11805	COG0508	dehydrogenase complex catalyzes the overall conversion of
BG586_RS11810	COG0567	Dehydrogenase, E1 component
BG586_RS11815	COG1121	(ABC) transporter
BG586_RS11820	COG0739	heme binding
BG586_RS11825	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BG586_RS11830	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
BG586_RS11840	COG0561	phosphatase activity
BG586_RS11845	COG3850	Histidine kinase
BG586_RS11855	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
BG586_RS11860	COG0393	Putative heavy-metal-binding
BG586_RS11865	COG2983	Belongs to the UPF0260 family
BG586_RS11870	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
BG586_RS11875	COG3283	Transcriptional regulator of aromatic amino acids metabolism
BG586_RS11880	COG4166	transmembrane transport
BG586_RS11885	COG4168	peptide transport system, permease
BG586_RS11890	COG4171	peptide transport system, permease
BG586_RS11895	COG4172	Belongs to the ABC transporter superfamily
BG586_RS11900	COG5645	(Lipo)protein
BG586_RS11915	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BG586_RS11920	COG4695	Portal protein
BG586_RS11970	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
BG586_RS12020	COG5301	cellulose 1,4-beta-cellobiosidase activity
BG586_RS12080	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BG586_RS12135	COG0629	single-stranded DNA binding
BG586_RS12175	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
BG586_RS12195	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
BG586_RS12205	COG0589	response to stress
BG586_RS12215	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
BG586_RS12220	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BG586_RS12230	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
BG586_RS12235	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
BG586_RS12240	COG2814	Major facilitator Superfamily
BG586_RS12245	COG2814	Major facilitator Superfamily
BG586_RS12250	COG3083	sulfuric ester hydrolase activity
BG586_RS12260	COG1309	transcriptional regulator
BG586_RS12265	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BG586_RS12270	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BG586_RS12280	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BG586_RS12295	COG3105	Protein conserved in bacteria
BG586_RS12300	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
BG586_RS12330	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
BG586_RS12335	COG1823	symporter activity
BG586_RS12340	COG0778	Nitroreductase
BG586_RS12350	COG0072	phenylalanine-tRNA ligase activity
BG586_RS12360	COG0791	NLP P60 protein
BG586_RS12365	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BG586_RS12370	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
BG586_RS12375	COG0539	negative regulation of cytoplasmic translation
BG586_RS12385	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
BG586_RS12390	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
BG586_RS12395	COG0284	orotidine-5'-phosphate decarboxylase activity
BG586_RS12400	COG0023	Translation Initiation Factor
BG586_RS12405	COG0741	lytic transglycosylase activity
BG586_RS12415	COG0779	Required for maturation of 30S ribosomal subunits
BG586_RS12420	COG0195	Participates in both transcription termination and antitermination
BG586_RS12425	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
BG586_RS12430	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
BG586_RS12435	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
BG586_RS12445	COG0590	tRNA wobble adenosine to inosine editing
BG586_RS12450	COG0513	Belongs to the DEAD box helicase family
BG586_RS12455	COG4785	May be involved in cell division
BG586_RS12465	COG5002	protein histidine kinase activity
BG586_RS12470	COG0745	RESPONSE REGULATOR receiver
BG586_RS12490	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BG586_RS12495	COG0527	aspartate kinase activity
BG586_RS12500	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BG586_RS12500	COG2190	(PTS) system
BG586_RS12500	COG1263	PTS System
BG586_RS12505	COG2926	Belongs to the UPF0265 family
BG586_RS12510	COG0248	Ppx GppA phosphatase
BG586_RS12515	COG2731	YhcH YjgK YiaL family protein
BG586_RS12520	COG1737	Transcriptional regulator
BG586_RS12525	COG0737	Belongs to the 5'-nucleotidase family
BG586_RS12530	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
BG586_RS12535	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
BG586_RS12540	COG2333	competence protein COMEC
BG586_RS12540	COG0658	competence protein
BG586_RS12545	COG1943	Transposase
BG586_RS12555	COG2831	hemolysin activation secretion protein
BG586_RS12560	COG3210	domain, Protein
BG586_RS12605	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BG586_RS12610	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BG586_RS12615	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
BG586_RS12630	COG2801	Transposase and inactivated derivatives
BG586_RS12635	COG0745	RESPONSE REGULATOR receiver
BG586_RS12650	COG0285	dihydrofolate synthase activity
BG586_RS12655	COG1448	Aminotransferase
BG586_RS12660	COG1444	tRNA N-acetyltransferase activity
BG586_RS12665	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
BG586_RS12670	COG0314	molybdopterin synthase activity
BG586_RS12675	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
BG586_RS12680	COG0315	cyclic pyranopterin monophosphate synthase activity
BG586_RS12690	COG2909	trisaccharide binding
BG586_RS12695	COG3005	denitrification pathway
BG586_RS12700	COG0243	molybdopterin cofactor binding
BG586_RS12710	COG2189	Belongs to the N(4) N(6)-methyltransferase family
BG586_RS12725	COG0538	isocitrate dehydrogenase activity
BG586_RS12730	COG1049	propionate catabolic process, 2-methylcitrate cycle
BG586_RS12735	COG0243	molybdopterin cofactor binding
BG586_RS12745	COG2363	Small membrane protein
BG586_RS12770	COG0626	cystathionine gamma-synthase activity
BG586_RS12795	COG4128	Pfam Zonular occludens toxin
BG586_RS12815	COG2801	Transposase and inactivated derivatives
BG586_RS12850	COG0737	Belongs to the 5'-nucleotidase family
BG586_RS12860	COG0280	phosphate acetyltransferase
BG586_RS12860	COG0857	belongs to the CobB CobQ family
BG586_RS12865	COG0288	reversible hydration of carbon dioxide
BG586_RS12870	COG0028	Belongs to the TPP enzyme family
BG586_RS12875	COG0440	acetolactate synthase activity
BG586_RS12880	COG0697	spore germination
BG586_RS12885	COG2801	Transposase and inactivated derivatives
BG586_RS12895	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
BG586_RS12895	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BG586_RS12905	COG0006	proline dipeptidase activity
BG586_RS12920	COG3074	FtsZ-dependent cytokinesis
BG586_RS12925	COG1435	thymidine kinase activity
BG586_RS12930	COG0641	radical SAM
BG586_RS12935	COG3119	arylsulfatase activity
BG586_RS12940	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BG586_RS12945	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BG586_RS12950	COG0730	response to heat
BG586_RS12955	COG1214	PFAM Peptidase M22, glycoprotease
BG586_RS12960	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
BG586_RS12965	COG2321	neutral zinc metallopeptidase
BG586_RS12970	COG1674	ftsk spoiiie
BG586_RS12975	COG1522	sequence-specific DNA binding
BG586_RS12980	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
BG586_RS12985	COG1846	Transcriptional regulator
BG586_RS12985	COG1940	carbohydrate kinase activity
BG586_RS12990	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
BG586_RS12995	COG3036	rescue of stalled ribosome
BG586_RS13000	COG2226	methyltransferase
BG586_RS13015	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BG586_RS13020	COG0583	DNA-binding transcription factor activity
BG586_RS13035	COG2969	positive regulation of protein catabolic process
BG586_RS13040	COG0625	glutathione transferase activity
BG586_RS13045	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
BG586_RS13055	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
BG586_RS13065	COG0556	nucleotide-excision repair
BG586_RS13080	COG2837	iron assimilation
BG586_RS13095	COG0613	PHP domain protein
BG586_RS13105	COG2925	Exonuclease
BG586_RS13225	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BG586_RS13245	COG1783	phage Terminase large subunit
BG586_RS13250	COG3728	DNA packaging
BG586_RS13325	COG0305	Participates in initiation and elongation during chromosome replication
BG586_RS13365	COG2801	Transposase and inactivated derivatives
BG586_RS13490	COG0281	malic enzyme
BG586_RS13490	COG0280	phosphate acetyltransferase
BG586_RS13495	COG0189	ligase activity
BG586_RS13505	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BG586_RS13515	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
BG586_RS13520	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BG586_RS13520	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BG586_RS13545	COG2801	Transposase and inactivated derivatives
BG586_RS13580	COG1724	mRNA binding
BG586_RS13585	COG1598	PFAM Uncharacterised protein family UPF0150
BG586_RS13605	COG5339	Protein conserved in bacteria
BG586_RS13610	COG0159	tryptophan synthase activity
BG586_RS13620	COG4221	oxidoreductase activity
BG586_RS13625	COG1757	Na H antiporter
BG586_RS13630	COG2916	Histone family protein nucleoid-structuring protein H-NS
BG586_RS13635	COG0788	formyltetrahydrofolate deformylase activity
BG586_RS13640	COG2949	membrane
BG586_RS13645	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BG586_RS13650	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BG586_RS13655	COG1530	ribonuclease E activity
BG586_RS13665	COG1518	maintenance of DNA repeat elements
BG586_RS13710	COG0675	Transposase, IS605 OrfB family
BG586_RS13725	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BG586_RS13730	COG0583	DNA-binding transcription factor activity
BG586_RS13735	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
BG586_RS13740	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
BG586_RS13745	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
BG586_RS13765	COG1523	belongs to the glycosyl hydrolase 13 family
BG586_RS13770	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
BG586_RS13775	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BG586_RS13775	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
BG586_RS13780	COG1105	Belongs to the carbohydrate kinase PfkB family
BG586_RS13785	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BG586_RS13785	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BG586_RS13785	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
BG586_RS13800	COG1704	LemA family
BG586_RS13825	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
BG586_RS13835	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
BG586_RS13845	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BG586_RS13850	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BG586_RS13855	COG0575	Belongs to the CDS family
BG586_RS13860	COG0750	zinc metalloprotease
BG586_RS13875	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BG586_RS13880	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BG586_RS13885	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BG586_RS13890	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BG586_RS13890	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
BG586_RS13895	COG0134	indole-3-glycerol-phosphate synthase activity
BG586_RS13895	COG0135	phosphoribosylanthranilate isomerase activity
BG586_RS13900	COG3098	single-species biofilm formation
BG586_RS13905	COG0564	pseudouridine synthase activity
BG586_RS13910	COG3140	Belongs to the UPF0181 family
BG586_RS13920	COG3025	triphosphatase activity
BG586_RS13925	COG3106	COG3106 Predicted ATPase
BG586_RS13940	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
BG586_RS13960	COG0495	leucyl-tRNA aminoacylation
BG586_RS13965	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
BG586_RS13970	COG1466	dna polymerase III delta subunit
BG586_RS13975	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
BG586_RS13980	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
BG586_RS13980	COG0237	dephospho-CoA kinase activity
BG586_RS13990	COG1459	type II secretion system
BG586_RS13995	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BG586_RS14000	COG4969	Belongs to the N-Me-Phe pilin family
BG586_RS14005	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
BG586_RS14015	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
BG586_RS14020	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
BG586_RS14025	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
BG586_RS14030	COG0730	response to heat
BG586_RS14035	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BG586_RS14040	COG0617	tRNA 3'-terminal CCA addition
BG586_RS14045	COG1275	C4-dicarboxylate transporter malic acid transport protein
BG586_RS14050	COG2975	iron-sulfur cluster assembly
BG586_RS14055	COG0633	Ferredoxin
BG586_RS14070	COG2852	Protein conserved in bacteria
BG586_RS14080	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
BG586_RS14090	COG0822	iron-sulfur transferase activity
BG586_RS14100	COG1959	2 iron, 2 sulfur cluster binding
BG586_RS14110	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BG586_RS14115	COG0784	Response regulator, receiver
BG586_RS14115	COG5002	protein histidine kinase activity
BG586_RS14115	COG2198	Histidine kinase
BG586_RS14140	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
BG586_RS14145	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
BG586_RS14220	COG2801	Transposase and inactivated derivatives
BG586_RS14320	COG0545	Peptidyl-prolyl cis-trans isomerase
BG586_RS14330	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BG586_RS14340	COG2830	Protein of unknown function (DUF452)
BG586_RS14345	COG0500	methyltransferase
BG586_RS14360	COG4608	Belongs to the ABC transporter superfamily
BG586_RS14390	COG1192	Involved in chromosome partitioning
BG586_RS14395	COG2801	Transposase and inactivated derivatives
BG586_RS14435	COG2801	Transposase and inactivated derivatives
BG586_RS14440	COG3691	Protein conserved in bacteria
BG586_RS14450	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BG586_RS14455	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BG586_RS14460	COG3084	Protein conserved in bacteria
BG586_RS14465	COG1763	Mo-molybdopterin cofactor biosynthetic process
BG586_RS14475	COG0676	glucose-6-phosphate 1-epimerase activity
BG586_RS14485	COG2801	Transposase and inactivated derivatives
BG586_RS14505	COG0697	spore germination
BG586_RS14515	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BG586_RS14520	COG2840	Smr protein MutS2
BG586_RS14530	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
BG586_RS14545	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
BG586_RS14550	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BG586_RS14550	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BG586_RS14555	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
BG586_RS14560	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BG586_RS14575	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BG586_RS14580	COG4166	transmembrane transport
BG586_RS14590	COG0444	Belongs to the ABC transporter superfamily
BG586_RS14595	COG4172	Belongs to the ABC transporter superfamily
BG586_RS14605	COG3423	Transcriptional regulator
BG586_RS14610	COG2801	Transposase and inactivated derivatives
BG586_RS14620	COG2842	Transposition protein
BG586_RS14660	COG4382	Mu-like prophage protein Gp16
BG586_RS14695	COG0640	Transcriptional regulator