locus-tag	class	description
BG590_RS00005	COG0445	tRNA wobble uridine modification
BG590_RS00015	COG0357	Ribosomal RNA small subunit methyltransferase G
BG590_RS00020	COG2211	Major facilitator Superfamily
BG590_RS00030	COG0667	Aldo Keto reductase
BG590_RS00035	COG2271	Major facilitator Superfamily
BG590_RS00040	COG0584	glycerophosphoryl diester phosphodiesterase
BG590_RS00045	COG2271	Major facilitator Superfamily
BG590_RS00090	COG1129	ABC transporter
BG590_RS00095	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BG590_RS00100	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BG590_RS00105	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BG590_RS00110	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
BG590_RS00115	COG2731	YhcH YjgK YiaL family protein
BG590_RS00120	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
BG590_RS00155	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BG590_RS00160	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BG590_RS00185	COG2502	aspartate--ammonia ligase
BG590_RS00190	COG1522	sequence-specific DNA binding
BG590_RS00200	COG0716	FMN binding
BG590_RS00205	COG0747	negative chemotaxis
BG590_RS00215	COG5301	cellulose 1,4-beta-cellobiosidase activity
BG590_RS00250	COG2801	Transposase and inactivated derivatives
BG590_RS00255	COG3423	Transcriptional regulator
BG590_RS00260	COG2932	Transcriptional regulator
BG590_RS00285	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
BG590_RS00300	COG0259	pyridoxamine-phosphate oxidase activity
BG590_RS00310	COG3276	selenocysteine insertion sequence binding
BG590_RS00315	COG2358	TRAP transporter, solute receptor (TAXI family
BG590_RS00330	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BG590_RS00335	COG0569	domain protein
BG590_RS00340	COG3477	response to acidic pH
BG590_RS00345	COG1012	belongs to the aldehyde dehydrogenase family
BG590_RS00350	COG1454	alcohol dehydrogenase
BG590_RS00355	COG1263	PTS System
BG590_RS00355	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BG590_RS00360	COG1879	ABC-type sugar transport system periplasmic component
BG590_RS00365	COG1172	Belongs to the binding-protein-dependent transport system permease family
BG590_RS00370	COG1129	ABC transporter
BG590_RS00375	COG0235	Class ii aldolase
BG590_RS00380	COG4154	Belongs to the RbsD FucU family
BG590_RS00385	COG1070	Carbohydrate kinase
BG590_RS00390	COG2407	Converts the aldose L-fucose into the corresponding ketose L-fuculose
BG590_RS00395	COG1349	DNA-binding transcription factor activity
BG590_RS00435	COG1629	transport
BG590_RS00435	COG4206	TonB-dependent receptor
BG590_RS00455	COG3676	manually curated
BG590_RS00465	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
BG590_RS00470	COG1595	DNA-templated transcription, initiation
BG590_RS00485	COG0673	inositol 2-dehydrogenase activity
BG590_RS00490	COG1305	Transglutaminase-like
BG590_RS00500	COG2608	mercury ion transmembrane transporter activity
BG590_RS00505	COG3730	PTS system glucitol sorbitol-specific
BG590_RS00520	COG1028	Short-chain dehydrogenase reductase Sdr
BG590_RS00525	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
BG590_RS00530	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BG590_RS00535	COG1349	DNA-binding transcription factor activity
BG590_RS00540	COG0517	IMP dehydrogenase activity
BG590_RS00540	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
BG590_RS00560	COG3722	fumarate hydratase activity
BG590_RS00565	COG0490	domain, Protein
BG590_RS00565	COG0471	metal ion transport
BG590_RS00575	COG1396	sequence-specific DNA binding
BG590_RS00580	COG3423	Transcriptional regulator
BG590_RS00585	COG2801	Transposase and inactivated derivatives
BG590_RS00590	COG4214	carbohydrate transport
BG590_RS00595	COG1129	ABC transporter
BG590_RS00600	COG4213	ABC transporter substrate-binding protein
BG590_RS00605	COG2115	Belongs to the xylose isomerase family
BG590_RS00610	COG1070	Carbohydrate kinase
BG590_RS00620	COG3545	Serine hydrolase
BG590_RS00630	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
BG590_RS00635	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BG590_RS00640	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BG590_RS00645	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
BG590_RS00660	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BG590_RS00720	COG0697	spore germination
BG590_RS00725	COG0346	lactoylglutathione lyase activity
BG590_RS00735	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
BG590_RS00740	COG0741	lytic transglycosylase activity
BG590_RS00765	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BG590_RS00770	COG1349	DNA-binding transcription factor activity
BG590_RS00775	COG2084	Dehydrogenase
BG590_RS00780	COG3395	kinase activity
BG590_RS00785	COG0235	Class ii aldolase
BG590_RS00790	COG3622	Belongs to the hyi family
BG590_RS00795	COG2610	gluconate transmembrane transporter activity
BG590_RS00805	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
BG590_RS00830	COG4545	Glutaredoxin-related protein
BG590_RS00835	COG4804	nuclease activity
BG590_RS00855	COG0814	amino acid
BG590_RS00860	COG2964	Protein conserved in bacteria
BG590_RS00875	COG2832	Protein of unknown function (DUF454)
BG590_RS00895	COG3085	chromosome segregation
BG590_RS00905	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
BG590_RS00915	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BG590_RS00925	COG0521	Mo-molybdopterin cofactor biosynthetic process
BG590_RS00945	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BG590_RS00990	COG1840	ABC-type Fe3 transport system, periplasmic component
BG590_RS01000	COG1349	DNA-binding transcription factor activity
BG590_RS01005	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BG590_RS01025	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BG590_RS01035	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
BG590_RS01045	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
BG590_RS01055	COG0200	Binds to the 23S rRNA
BG590_RS01060	COG0201	protein transport
BG590_RS01070	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
BG590_RS01080	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BG590_RS01085	COG0202	RNA polymerase activity
BG590_RS01090	COG0203	ribosomal protein L17
BG590_RS01095	COG2207	Transcriptional regulator
BG590_RS01095	COG1609	Transcriptional regulator
BG590_RS01100	COG1609	Transcriptional regulator
BG590_RS01105	COG3265	gluconokinase activity
BG590_RS01110	COG2610	gluconate transmembrane transporter activity
BG590_RS01115	COG0583	DNA-binding transcription factor activity
BG590_RS01125	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
BG590_RS01130	COG1012	belongs to the aldehyde dehydrogenase family
BG590_RS01135	COG3718	enzyme involved in inositol metabolism
BG590_RS01150	COG1129	ABC transporter
BG590_RS01155	COG1172	Belongs to the binding-protein-dependent transport system permease family
BG590_RS01160	COG0673	inositol 2-dehydrogenase activity
BG590_RS01175	COG0673	inositol 2-dehydrogenase activity
BG590_RS01185	COG3962	Belongs to the TPP enzyme family
BG590_RS01200	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BG590_RS01210	COG2190	(PTS) system
BG590_RS01210	COG1263	PTS System
BG590_RS01210	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BG590_RS01215	COG0228	four-way junction DNA binding
BG590_RS01225	COG0336	Belongs to the RNA methyltransferase TrmD family
BG590_RS01245	COG1694	Mazg nucleotide pyrophosphohydrolase
BG590_RS01250	COG2850	peptidyl-arginine hydroxylation
BG590_RS01255	COG0439	Biotin carboxylase
BG590_RS01260	COG0511	ligase activity, forming carbon-carbon bonds
BG590_RS01270	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
BG590_RS01285	COG1876	peptidase activity
BG590_RS01295	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
BG590_RS01300	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BG590_RS01310	COG0606	chelatase, subunit chli
BG590_RS01320	COG0210	DNA helicase
BG590_RS01320	COG0210	DNA helicase
BG590_RS01355	COG1475	DNA binding
BG590_RS01365	COG2801	Transposase and inactivated derivatives
BG590_RS01405	COG2267	carboxylic ester hydrolase activity
BG590_RS01415	COG1442	glycosyl transferase family 8
BG590_RS01420	COG3691	Protein conserved in bacteria
BG590_RS01430	COG1879	ABC-type sugar transport system periplasmic component
BG590_RS01440	COG2801	Transposase and inactivated derivatives
BG590_RS01445	COG1879	ABC-type sugar transport system periplasmic component
BG590_RS01455	COG4211	Belongs to the binding-protein-dependent transport system permease family
BG590_RS01460	COG0747	negative chemotaxis
BG590_RS01465	COG3676	manually curated
BG590_RS01475	COG1757	Na H antiporter
BG590_RS01480	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BG590_RS01505	COG4795	General secretion pathway protein
BG590_RS01520	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
BG590_RS01530	COG0747	negative chemotaxis
BG590_RS01555	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
BG590_RS01555	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
BG590_RS01560	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BG590_RS01575	COG1309	transcriptional regulator
BG590_RS01600	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BG590_RS01605	COG2003	Belongs to the UPF0758 family
BG590_RS01620	COG1349	DNA-binding transcription factor activity
BG590_RS01625	COG3395	kinase activity
BG590_RS01635	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
BG590_RS01640	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
BG590_RS01645	COG0076	glutamate decarboxylase activity
BG590_RS01650	COG3111	PFAM Bacterial OB fold (BOF) protein
BG590_RS01655	COG2249	NAD(P)H dehydrogenase (quinone) activity
BG590_RS01660	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
BG590_RS01665	COG3062	negative regulation of establishment of protein localization
BG590_RS01670	COG0243	molybdopterin cofactor binding
BG590_RS01675	COG0437	4 iron, 4 sulfur cluster binding
BG590_RS01680	COG0348	domain, Protein
BG590_RS01685	COG3043	anaerobic respiration
BG590_RS01690	COG3005	denitrification pathway
BG590_RS01695	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
BG590_RS01705	COG3005	denitrification pathway
BG590_RS01715	COG3381	protein complex oligomerization
BG590_RS01740	COG2801	Transposase and inactivated derivatives
BG590_RS01745	COG0494	nUDIX hydrolase
BG590_RS01765	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
BG590_RS01770	COG4145	pantothenate transmembrane transporter activity
BG590_RS01775	COG3924	membrane
BG590_RS01780	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
BG590_RS01785	COG2853	Lipoprotein
BG590_RS01790	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BG590_RS01800	COG1858	cytochrome C peroxidase
BG590_RS01830	COG1309	transcriptional regulator
BG590_RS01835	COG0583	DNA-binding transcription factor activity
BG590_RS01840	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
BG590_RS01840	COG0678	peroxiredoxin activity
BG590_RS01845	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
BG590_RS01850	COG1803	Methylglyoxal synthase
BG590_RS01855	COG1289	transmembrane transporter activity
BG590_RS01870	COG2995	paraquat-inducible protein a
BG590_RS01875	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
BG590_RS01895	COG0416	fatty acid biosynthetic process
BG590_RS01905	COG1399	metal-binding, possibly nucleic acid-binding protein
BG590_RS01910	COG4137	Cytochrome C assembly protein
BG590_RS01915	COG4536	flavin adenine dinucleotide binding
BG590_RS01920	COG0733	neurotransmitter:sodium symporter activity
BG590_RS01930	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
BG590_RS01935	COG0513	Belongs to the DEAD box helicase family
BG590_RS01940	COG3691	Protein conserved in bacteria
BG590_RS01945	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BG590_RS01950	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BG590_RS01955	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BG590_RS01960	COG3084	Protein conserved in bacteria
BG590_RS01975	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
BG590_RS01980	COG0676	glucose-6-phosphate 1-epimerase activity
BG590_RS01990	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
BG590_RS01995	COG0024	Methionine aminopeptidase
BG590_RS02005	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
BG590_RS02010	COG1178	ABC-type Fe3 transport system permease component
BG590_RS02015	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BG590_RS02020	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BG590_RS02025	COG2190	(PTS) system
BG590_RS02030	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BG590_RS02035	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BG590_RS02040	COG1621	beta-fructofuranosidase activity
BG590_RS02055	COG1758	RNA polymerase activity
BG590_RS02060	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BG590_RS02075	COG0230	Belongs to the bacterial ribosomal protein bL34 family
BG590_RS02080	COG0594	ribonuclease P activity
BG590_RS02085	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
BG590_RS02095	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
BG590_RS02110	COG1216	Glycosyl transferase, family 2
BG590_RS02120	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BG590_RS02130	COG1088	dTDP-glucose 4,6-dehydratase activity
BG590_RS02135	COG3307	-O-antigen
BG590_RS02155	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BG590_RS02165	COG1575	Belongs to the MenA family. Type 1 subfamily
BG590_RS02170	COG1720	tRNA m6t6A37 methyltransferase activity
BG590_RS02180	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BG590_RS02185	COG1047	Peptidyl-prolyl cis-trans
BG590_RS02195	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BG590_RS02200	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
BG590_RS02205	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BG590_RS02215	COG0745	RESPONSE REGULATOR receiver
BG590_RS02220	COG2129	metallophosphoesterase
BG590_RS02225	COG3172	ATPase kinase involved in NAD metabolism
BG590_RS02230	COG0196	riboflavin kinase activity
BG590_RS02235	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
BG590_RS02250	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BG590_RS02255	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BG590_RS02260	COG4172	Belongs to the ABC transporter superfamily
BG590_RS02265	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BG590_RS02270	COG0601	transmembrane transport
BG590_RS02275	COG0747	negative chemotaxis
BG590_RS02285	COG1686	Belongs to the peptidase S11 family
BG590_RS02300	COG1620	l-lactate permease
BG590_RS02305	COG0247	lactate metabolic process
BG590_RS02310	COG1139	Iron-sulfur cluster binding protein
BG590_RS02315	COG1556	Lactate utilization protein
BG590_RS02330	COG1561	YicC-like family, N-terminal region
BG590_RS02335	COG0354	folic acid binding
BG590_RS02340	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
BG590_RS02350	COG1129	ABC transporter
BG590_RS02355	COG1172	Belongs to the binding-protein-dependent transport system permease family
BG590_RS02360	COG1879	ABC-type sugar transport system periplasmic component
BG590_RS02365	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BG590_RS02370	COG1609	Transcriptional regulator
BG590_RS02375	COG2197	response regulator
BG590_RS02385	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
BG590_RS02400	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
BG590_RS02410	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BG590_RS02415	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
BG590_RS02420	COG5016	pyruvate
BG590_RS02420	COG0511	ligase activity, forming carbon-carbon bonds
BG590_RS02425	COG3630	sodium ion export across plasma membrane
BG590_RS02430	COG1914	H( )-stimulated, divalent metal cation uptake system
BG590_RS02435	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
BG590_RS02440	COG1984	allophanate hydrolase subunit 2
BG590_RS02445	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
BG590_RS02450	COG1793	dna ligase
BG590_RS02495	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
BG590_RS02505	COG0006	proline dipeptidase activity
BG590_RS02510	COG3030	protein affecting phage T7 exclusion by the F plasmid
BG590_RS02520	COG1187	pseudouridine synthase activity
BG590_RS02535	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BG590_RS02545	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BG590_RS02550	COG5413	integral membrane protein
BG590_RS02570	COG4166	transmembrane transport
BG590_RS02575	COG1254	Belongs to the acylphosphatase family
BG590_RS02580	COG0308	aminopeptidase N
BG590_RS02585	COG0748	coenzyme F420 binding
BG590_RS02600	COG0814	amino acid
BG590_RS02605	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BG590_RS02625	COG1487	ribonuclease activity
BG590_RS02630	COG2195	Cleaves the N-terminal amino acid of tripeptides
BG590_RS02660	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BG590_RS02665	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BG590_RS02670	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BG590_RS02675	COG1121	(ABC) transporter
BG590_RS02700	COG3063	Type IV pilus biogenesis stability protein PilW
BG590_RS02705	COG2183	response to ionizing radiation
BG590_RS02710	COG0778	Nitroreductase
BG590_RS02715	COG0616	signal peptide processing
BG590_RS02740	COG0477	Major facilitator Superfamily
BG590_RS02760	COG3978	acetolactate synthase activity
BG590_RS02775	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
BG590_RS02780	COG0437	4 iron, 4 sulfur cluster binding
BG590_RS02785	COG3301	Polysulphide reductase, NrfD
BG590_RS02790	COG1138	Cytochrome C-type biogenesis protein
BG590_RS02795	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BG590_RS02800	COG4235	cytochrome complex assembly
BG590_RS02800	COG3088	subunit of a heme lyase
BG590_RS02810	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BG590_RS02815	COG1127	ABC transporter
BG590_RS02820	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BG590_RS02825	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
BG590_RS02830	COG2854	intermembrane phospholipid transfer
BG590_RS02840	COG5007	Belongs to the BolA IbaG family
BG590_RS02845	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BG590_RS02850	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
BG590_RS02865	COG0494	nUDIX hydrolase
BG590_RS02890	COG3423	Transcriptional regulator
BG590_RS02895	COG2801	Transposase and inactivated derivatives
BG590_RS02905	COG2842	Transposition protein
BG590_RS02945	COG4382	Mu-like prophage protein Gp16
BG590_RS02980	COG0640	Transcriptional regulator
BG590_RS02990	COG4373	Mu-like prophage FluMu protein gp28
BG590_RS03010	COG5005	Phage virion morphogenesis
BG590_RS03135	COG3392	D12 class N6 adenine-specific DNA methyltransferase
BG590_RS03150	COG2431	L-lysine efflux transmembrane transporter activity
BG590_RS03160	COG0501	Belongs to the peptidase M48B family
BG590_RS03165	COG1238	metal cluster binding
BG590_RS03170	COG2116	formate transmembrane transporter activity
BG590_RS03175	COG1882	Formate acetyltransferase
BG590_RS03185	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
BG590_RS03190	COG0339	signal peptide processing
BG590_RS03195	COG1605	Chorismate mutase
BG590_RS03195	COG0077	Prephenate dehydratase
BG590_RS03200	COG2841	Protein conserved in bacteria
BG590_RS03205	COG2268	Band 7 protein
BG590_RS03215	COG4773	Receptor
BG590_RS03225	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BG590_RS03240	COG1120	ATPase activity
BG590_RS03245	COG2814	Major facilitator Superfamily
BG590_RS03275	COG1120	ATPase activity
BG590_RS03280	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BG590_RS03295	COG4206	TonB-dependent receptor
BG590_RS03300	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
BG590_RS03320	COG1663	tetraacyldisaccharide 4'-kinase activity
BG590_RS03345	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
BG590_RS03350	COG0740	serine-type endopeptidase activity
BG590_RS03355	COG2166	iron-sulfur cluster assembly
BG590_RS03365	COG2226	methyltransferase
BG590_RS03375	COG1942	4-Oxalocrotonate Tautomerase
BG590_RS03380	COG0512	Glutamine amidotransferase of anthranilate synthase
BG590_RS03385	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BG590_RS03390	COG0009	L-threonylcarbamoyladenylate synthase
BG590_RS03395	COG1187	pseudouridine synthase activity
BG590_RS03400	COG3273	potassium ion transport
BG590_RS03400	COG0471	metal ion transport
BG590_RS03415	COG1640	4-alpha-glucanotransferase
BG590_RS03435	COG2965	DNA replication, synthesis of RNA primer
BG590_RS03455	COG0488	(ABC) transporter
BG590_RS03480	COG4657	Part of a membrane complex involved in electron transport
BG590_RS03485	COG2878	Part of a membrane complex involved in electron transport
BG590_RS03490	COG4656	Part of a membrane complex involved in electron transport
BG590_RS03495	COG2860	membrane
BG590_RS03500	COG4658	electron transport chain
BG590_RS03520	COG1560	Kdo2-lipid A biosynthetic process
BG590_RS03525	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BG590_RS03530	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
BG590_RS03535	COG1131	(ABC) transporter
BG590_RS03540	COG0842	Transport permease protein
BG590_RS03545	COG0725	ABC transporter, periplasmic molybdate-binding protein
BG590_RS03550	COG4149	molybdate abc transporter
BG590_RS03555	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
BG590_RS03560	COG2867	negative regulation of translational initiation
BG590_RS03565	COG2914	Belongs to the UPF0125 (RnfH) family
BG590_RS03575	COG2195	Cleaves the N-terminal amino acid of tripeptides
BG590_RS03590	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
BG590_RS03595	COG0194	GDP metabolic process
BG590_RS03600	COG1538	Outer membrane efflux protein
BG590_RS03605	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
BG590_RS03660	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BG590_RS03670	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BG590_RS03675	COG0488	(ABC) transporter
BG590_RS03680	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
BG590_RS03685	COG1611	Belongs to the LOG family
BG590_RS03690	COG3593	DNA synthesis involved in DNA repair
BG590_RS03695	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BG590_RS03725	COG4667	esterase of the alpha-beta hydrolase superfamily
BG590_RS03735	COG3719	Belongs to the RNase T2 family
BG590_RS03745	COG1252	NADH dehydrogenase
BG590_RS03750	COG1840	ABC-type Fe3 transport system, periplasmic component
BG590_RS03765	COG2252	PERMEase
BG590_RS03770	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BG590_RS03775	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BG590_RS03780	COG1862	Preprotein translocase
BG590_RS03785	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
BG590_RS03790	COG2017	converts alpha-aldose to the beta-anomer
BG590_RS03795	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
BG590_RS03800	COG1085	galactose-1-phosphate uridylyltransferase
BG590_RS03805	COG3739	integral membrane protein
BG590_RS03810	COG1408	metallophosphoesterase
BG590_RS03845	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BG590_RS03850	COG2801	Transposase and inactivated derivatives
BG590_RS03870	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BG590_RS03875	COG2233	PERMEase
BG590_RS03885	COG4316	Uncharacterized protein conserved in bacteria (DUF2251)
BG590_RS03890	COG0148	phosphopyruvate hydratase activity
BG590_RS03895	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BG590_RS03900	COG1472	Belongs to the glycosyl hydrolase 3 family
BG590_RS03905	COG0861	Integral membrane protein TerC family
BG590_RS03925	COG1584	GPR1 FUN34 yaaH family protein
BG590_RS03935	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BG590_RS03940	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BG590_RS03955	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BG590_RS03955	COG1263	PTS System
BG590_RS03955	COG2190	(PTS) system
BG590_RS03970	COG2920	part of a sulfur-relay system
BG590_RS03975	COG0670	Belongs to the BI1 family
BG590_RS03980	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BG590_RS03995	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
BG590_RS04000	COG0291	Belongs to the bacterial ribosomal protein bL35 family
BG590_RS04005	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BG590_RS04015	COG1965	Belongs to the frataxin family
BG590_RS04030	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BG590_RS04035	COG0564	pseudouridine synthase activity
BG590_RS04045	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
BG590_RS04050	COG1560	Kdo2-lipid A biosynthetic process
BG590_RS04055	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BG590_RS04060	COG0814	amino acid
BG590_RS04065	COG1760	l-serine dehydratase
BG590_RS04080	COG2027	D-alanyl-D-alanine carboxypeptidase
BG590_RS04085	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BG590_RS04100	COG1441	menaquinone biosynthetic process
BG590_RS04110	COG2814	Major facilitator Superfamily
BG590_RS04115	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BG590_RS04120	COG0232	Belongs to the dGTPase family. Type 2 subfamily
BG590_RS04145	COG0564	pseudouridine synthase activity
BG590_RS04150	COG3023	N-Acetylmuramoyl-L-alanine amidase
BG590_RS04155	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
BG590_RS04170	COG0626	cystathionine gamma-synthase activity
BG590_RS04175	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
BG590_RS04190	COG1702	phosphate starvation-inducible protein PhoH
BG590_RS04215	COG0583	DNA-binding transcription factor activity
BG590_RS04220	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
BG590_RS04245	COG0815	Transfers the fatty acyl group on membrane lipoproteins
BG590_RS04265	COG3381	protein complex oligomerization
BG590_RS04275	COG0791	NLP P60 protein
BG590_RS04280	COG2932	Transcriptional regulator
BG590_RS04290	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
BG590_RS04295	COG0330	HflC and HflK could
BG590_RS04330	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
BG590_RS04335	COG0534	Mate efflux family protein
BG590_RS04340	COG1074	ATP-dependent DNA helicase activity
BG590_RS04355	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
BG590_RS04365	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BG590_RS04370	COG0561	phosphatase activity
BG590_RS04380	COG1595	DNA-templated transcription, initiation
BG590_RS04385	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
BG590_RS04390	COG3026	antisigma factor binding
BG590_RS04400	COG0318	PFAM AMP-dependent synthetase and ligase
BG590_RS04405	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
BG590_RS04410	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BG590_RS04415	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BG590_RS04420	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
BG590_RS04425	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
BG590_RS04425	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
BG590_RS04430	COG1160	GTP binding
BG590_RS04440	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BG590_RS04450	COG1757	Na H antiporter
BG590_RS04455	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
BG590_RS04460	COG4172	Belongs to the ABC transporter superfamily
BG590_RS04465	COG0444	Belongs to the ABC transporter superfamily
BG590_RS04475	COG4166	transmembrane transport
BG590_RS04480	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BG590_RS04495	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BG590_RS04500	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
BG590_RS04505	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BG590_RS04505	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BG590_RS04510	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
BG590_RS04525	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
BG590_RS04535	COG2840	Smr protein MutS2
BG590_RS04540	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BG590_RS04550	COG0697	spore germination
BG590_RS04570	COG2801	Transposase and inactivated derivatives
BG590_RS04580	COG0676	glucose-6-phosphate 1-epimerase activity
BG590_RS04590	COG1763	Mo-molybdopterin cofactor biosynthetic process
BG590_RS04595	COG3084	Protein conserved in bacteria
BG590_RS04600	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BG590_RS04605	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BG590_RS04615	COG3691	Protein conserved in bacteria
BG590_RS04620	COG2801	Transposase and inactivated derivatives
BG590_RS04655	COG1192	Involved in chromosome partitioning
BG590_RS04685	COG4608	Belongs to the ABC transporter superfamily
BG590_RS04700	COG0500	methyltransferase
BG590_RS04705	COG2830	Protein of unknown function (DUF452)
BG590_RS04715	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BG590_RS04725	COG0545	Peptidyl-prolyl cis-trans isomerase
BG590_RS04825	COG2801	Transposase and inactivated derivatives
BG590_RS04880	COG2801	Transposase and inactivated derivatives
BG590_RS04905	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
BG590_RS04910	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
BG590_RS04935	COG5002	protein histidine kinase activity
BG590_RS04935	COG2198	Histidine kinase
BG590_RS04935	COG0784	Response regulator, receiver
BG590_RS04940	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BG590_RS04950	COG1959	2 iron, 2 sulfur cluster binding
BG590_RS04960	COG0822	iron-sulfur transferase activity
BG590_RS04970	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
BG590_RS04980	COG2852	Protein conserved in bacteria
BG590_RS04995	COG0633	Ferredoxin
BG590_RS05000	COG2975	iron-sulfur cluster assembly
BG590_RS05005	COG1275	C4-dicarboxylate transporter malic acid transport protein
BG590_RS05010	COG0617	tRNA 3'-terminal CCA addition
BG590_RS05015	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BG590_RS05020	COG0730	response to heat
BG590_RS05025	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
BG590_RS05030	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
BG590_RS05035	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
BG590_RS05045	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
BG590_RS05050	COG4969	Belongs to the N-Me-Phe pilin family
BG590_RS05055	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BG590_RS05060	COG1459	type II secretion system
BG590_RS05070	COG0237	dephospho-CoA kinase activity
BG590_RS05070	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
BG590_RS05075	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
BG590_RS05080	COG1466	dna polymerase III delta subunit
BG590_RS05085	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
BG590_RS05090	COG0495	leucyl-tRNA aminoacylation
BG590_RS05110	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
BG590_RS05125	COG3106	COG3106 Predicted ATPase
BG590_RS05130	COG3025	triphosphatase activity
BG590_RS05140	COG3140	Belongs to the UPF0181 family
BG590_RS05145	COG0564	pseudouridine synthase activity
BG590_RS05150	COG3098	single-species biofilm formation
BG590_RS05155	COG0135	phosphoribosylanthranilate isomerase activity
BG590_RS05155	COG0134	indole-3-glycerol-phosphate synthase activity
BG590_RS05160	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BG590_RS05160	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
BG590_RS05165	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BG590_RS05170	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BG590_RS05175	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BG590_RS05190	COG0750	zinc metalloprotease
BG590_RS05195	COG0575	Belongs to the CDS family
BG590_RS05200	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BG590_RS05205	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BG590_RS05215	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
BG590_RS05225	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
BG590_RS05250	COG1704	LemA family
BG590_RS05265	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
BG590_RS05265	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BG590_RS05265	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BG590_RS05270	COG1105	Belongs to the carbohydrate kinase PfkB family
BG590_RS05275	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
BG590_RS05275	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BG590_RS05280	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
BG590_RS05285	COG1523	belongs to the glycosyl hydrolase 13 family
BG590_RS05305	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
BG590_RS05310	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
BG590_RS05315	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
BG590_RS05320	COG0583	DNA-binding transcription factor activity
BG590_RS05325	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BG590_RS05345	COG0582	viral genome integration into host DNA
BG590_RS05355	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BG590_RS05360	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BG590_RS05365	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
BG590_RS05375	COG3264	Mechanosensitive ion channel
BG590_RS05375	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
BG590_RS05380	COG0318	PFAM AMP-dependent synthetase and ligase
BG590_RS05390	COG0596	Alpha beta hydrolase
BG590_RS05395	COG2226	methyltransferase
BG590_RS05405	COG0586	Pfam SNARE associated Golgi protein
BG590_RS05415	COG0717	Belongs to the dCTP deaminase family
BG590_RS05420	COG0572	uridine kinase
BG590_RS05430	COG1077	Cell shape determining protein MreB Mrl
BG590_RS05435	COG1792	Involved in formation and maintenance of cell shape
BG590_RS05440	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
BG590_RS05445	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BG590_RS05450	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BG590_RS05455	COG0121	glutamine amidotransferase
BG590_RS05460	COG0142	geranyltranstransferase activity
BG590_RS05465	COG1722	exodeoxyribonuclease VII activity
BG590_RS05470	COG0633	Ferredoxin
BG590_RS05470	COG3217	Mosc domain protein beta barrel domain protein
BG590_RS05475	COG1368	sulfuric ester hydrolase activity
BG590_RS05490	COG0671	phosphoesterase, PA-phosphatase related
BG590_RS05495	COG1534	Rna-binding protein
BG590_RS05500	COG0463	Glycosyl transferase, family 2
BG590_RS05505	COG0859	PFAM glycosyl transferase family 9
BG590_RS05515	COG0328	RNA-DNA hybrid ribonuclease activity
BG590_RS05520	COG1286	toxin biosynthetic process
BG590_RS05535	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
BG590_RS05560	COG0305	Participates in initiation and elongation during chromosome replication
BG590_RS05590	COG0629	single-stranded DNA binding
BG590_RS05635	COG2132	Multicopper oxidase
BG590_RS05655	COG0667	Aldo Keto reductase
BG590_RS05675	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BG590_RS05885	COG2826	transposase and inactivated derivatives, IS30 family
BG590_RS05915	COG0629	single-stranded DNA binding
BG590_RS05920	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BG590_RS05925	COG0659	secondary active sulfate transmembrane transporter activity
BG590_RS05935	COG1122	ATPase activity
BG590_RS05945	COG1199	ATP-dependent helicase activity
BG590_RS05955	COG1346	cytolysis
BG590_RS05960	COG1132	(ABC) transporter
BG590_RS05975	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BG590_RS05980	COG0167	dihydroorotate dehydrogenase activity
BG590_RS05985	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
BG590_RS05990	COG0508	dehydrogenase complex catalyzes the overall conversion of
BG590_RS05995	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BG590_RS06020	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BG590_RS06025	COG3676	manually curated
BG590_RS06030	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
BG590_RS06035	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BG590_RS06055	COG4991	sh3 domain protein
BG590_RS06060	COG0306	phosphate transporter
BG590_RS06065	COG1392	Phosphate transport regulator
BG590_RS06070	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
BG590_RS06085	COG4604	ABC transporter, ATP-binding protein
BG590_RS06095	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BG590_RS06100	COG4607	ABC-type enterochelin transport system periplasmic component
BG590_RS06105	COG0305	Participates in initiation and elongation during chromosome replication
BG590_RS06110	COG3100	YcgL domain-containing protein
BG590_RS06115	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
BG590_RS06125	COG0583	DNA-binding transcription factor activity
BG590_RS06145	COG0425	Belongs to the sulfur carrier protein TusA family
BG590_RS06160	COG1172	Belongs to the binding-protein-dependent transport system permease family
BG590_RS06165	COG1172	Belongs to the binding-protein-dependent transport system permease family
BG590_RS06185	COG0697	spore germination
BG590_RS06190	COG1278	Cold shock
BG590_RS06205	COG3945	hemerythrin HHE cation binding domain
BG590_RS06210	COG0425	Belongs to the sulfur carrier protein TusA family
BG590_RS06215	COG2932	Transcriptional regulator
BG590_RS06250	COG3787	Belongs to the UPF0306 family
BG590_RS06260	COG1811	Na channel or pump
BG590_RS06270	COG3028	Belongs to the UPF0307 family
BG590_RS06275	COG0312	modulator of DNA gyrase
BG590_RS06280	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
BG590_RS06285	COG4409	exo-alpha-(2->6)-sialidase activity
BG590_RS06385	COG0582	viral genome integration into host DNA
BG590_RS06395	COG1496	oxidoreductase activity
BG590_RS06400	COG0251	oxidation-reduction process
BG590_RS06410	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BG590_RS06415	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BG590_RS06425	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BG590_RS06445	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BG590_RS06455	COG1509	lysine 2,3-aminomutase activity
BG590_RS06460	COG0017	Asparaginyl-tRNA synthetase
BG590_RS06465	COG0582	viral genome integration into host DNA
BG590_RS06565	COG2801	Transposase and inactivated derivatives
BG590_RS06595	COG3683	transport system, periplasmic component
BG590_RS06600	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
BG590_RS06605	COG1115	amino acid carrier protein
BG590_RS06610	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
BG590_RS06615	COG0045	succinate-CoA ligase (ADP-forming) activity
BG590_RS06620	COG0508	dehydrogenase complex catalyzes the overall conversion of
BG590_RS06625	COG0567	Dehydrogenase, E1 component
BG590_RS06630	COG1121	(ABC) transporter
BG590_RS06635	COG0739	heme binding
BG590_RS06640	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BG590_RS06645	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
BG590_RS06655	COG0561	phosphatase activity
BG590_RS06660	COG3850	Histidine kinase
BG590_RS06670	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
BG590_RS06675	COG0393	Putative heavy-metal-binding
BG590_RS06680	COG2983	Belongs to the UPF0260 family
BG590_RS06685	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
BG590_RS06690	COG3283	Transcriptional regulator of aromatic amino acids metabolism
BG590_RS06695	COG4166	transmembrane transport
BG590_RS06700	COG4168	peptide transport system, permease
BG590_RS06705	COG4171	peptide transport system, permease
BG590_RS06710	COG4172	Belongs to the ABC transporter superfamily
BG590_RS06715	COG5645	(Lipo)protein
BG590_RS06730	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BG590_RS06735	COG4695	Portal protein
BG590_RS06785	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
BG590_RS06815	COG2801	Transposase and inactivated derivatives
BG590_RS06845	COG5301	cellulose 1,4-beta-cellobiosidase activity
BG590_RS06905	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BG590_RS06960	COG0629	single-stranded DNA binding
BG590_RS07000	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
BG590_RS07020	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
BG590_RS07030	COG0589	response to stress
BG590_RS07040	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
BG590_RS07045	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BG590_RS07055	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
BG590_RS07060	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
BG590_RS07065	COG2814	Major facilitator Superfamily
BG590_RS07070	COG2814	Major facilitator Superfamily
BG590_RS07075	COG3083	sulfuric ester hydrolase activity
BG590_RS07085	COG1309	transcriptional regulator
BG590_RS07090	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BG590_RS07095	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BG590_RS07105	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BG590_RS07120	COG3105	Protein conserved in bacteria
BG590_RS07125	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
BG590_RS07155	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
BG590_RS07160	COG1823	symporter activity
BG590_RS07165	COG0778	Nitroreductase
BG590_RS07175	COG0072	phenylalanine-tRNA ligase activity
BG590_RS07185	COG0791	NLP P60 protein
BG590_RS07190	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BG590_RS07195	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
BG590_RS07200	COG0539	negative regulation of cytoplasmic translation
BG590_RS07210	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
BG590_RS07215	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
BG590_RS07220	COG0284	orotidine-5'-phosphate decarboxylase activity
BG590_RS07225	COG0023	Translation Initiation Factor
BG590_RS07230	COG0741	lytic transglycosylase activity
BG590_RS07240	COG0779	Required for maturation of 30S ribosomal subunits
BG590_RS07245	COG0195	Participates in both transcription termination and antitermination
BG590_RS07250	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
BG590_RS07255	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
BG590_RS07260	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
BG590_RS07270	COG0590	tRNA wobble adenosine to inosine editing
BG590_RS07275	COG0513	Belongs to the DEAD box helicase family
BG590_RS07280	COG4785	May be involved in cell division
BG590_RS07290	COG5002	protein histidine kinase activity
BG590_RS07295	COG0745	RESPONSE REGULATOR receiver
BG590_RS07315	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BG590_RS07320	COG0527	aspartate kinase activity
BG590_RS07325	COG1263	PTS System
BG590_RS07325	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BG590_RS07325	COG2190	(PTS) system
BG590_RS07330	COG2926	Belongs to the UPF0265 family
BG590_RS07335	COG0248	Ppx GppA phosphatase
BG590_RS07340	COG2731	YhcH YjgK YiaL family protein
BG590_RS07345	COG1737	Transcriptional regulator
BG590_RS07350	COG0737	Belongs to the 5'-nucleotidase family
BG590_RS07355	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
BG590_RS07360	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
BG590_RS07365	COG0658	competence protein
BG590_RS07365	COG2333	competence protein COMEC
BG590_RS07370	COG1943	Transposase
BG590_RS07380	COG2831	hemolysin activation secretion protein
BG590_RS07385	COG3210	domain, Protein
BG590_RS07430	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BG590_RS07435	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BG590_RS07440	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
BG590_RS07445	COG1136	(ABC) transporter
BG590_RS07445	COG0577	efflux transmembrane transporter activity
BG590_RS07450	COG2205	protein histidine kinase activity
BG590_RS07460	COG2801	Transposase and inactivated derivatives
BG590_RS07465	COG0745	RESPONSE REGULATOR receiver
BG590_RS07480	COG0285	dihydrofolate synthase activity
BG590_RS07485	COG1448	Aminotransferase
BG590_RS07490	COG1444	tRNA N-acetyltransferase activity
BG590_RS07495	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
BG590_RS07500	COG0314	molybdopterin synthase activity
BG590_RS07505	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
BG590_RS07510	COG0315	cyclic pyranopterin monophosphate synthase activity
BG590_RS07520	COG2909	trisaccharide binding
BG590_RS07525	COG3005	denitrification pathway
BG590_RS07530	COG0243	molybdopterin cofactor binding
BG590_RS07540	COG2189	Belongs to the N(4) N(6)-methyltransferase family
BG590_RS07560	COG2801	Transposase and inactivated derivatives
BG590_RS07565	COG0697	spore germination
BG590_RS07570	COG0440	acetolactate synthase activity
BG590_RS07575	COG0028	Belongs to the TPP enzyme family
BG590_RS07580	COG0288	reversible hydration of carbon dioxide
BG590_RS07585	COG0857	belongs to the CobB CobQ family
BG590_RS07585	COG0280	phosphate acetyltransferase
BG590_RS07595	COG0737	Belongs to the 5'-nucleotidase family
BG590_RS07630	COG2801	Transposase and inactivated derivatives
BG590_RS07650	COG4128	Pfam Zonular occludens toxin
BG590_RS07675	COG0626	cystathionine gamma-synthase activity
BG590_RS07700	COG2363	Small membrane protein
BG590_RS07710	COG0243	molybdopterin cofactor binding
BG590_RS07715	COG1049	propionate catabolic process, 2-methylcitrate cycle
BG590_RS07720	COG0538	isocitrate dehydrogenase activity
BG590_RS07735	COG2801	Transposase and inactivated derivatives
BG590_RS07745	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
BG590_RS07745	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BG590_RS07755	COG0006	proline dipeptidase activity
BG590_RS07770	COG3074	FtsZ-dependent cytokinesis
BG590_RS07775	COG1435	thymidine kinase activity
BG590_RS07780	COG0641	radical SAM
BG590_RS07785	COG3119	arylsulfatase activity
BG590_RS07790	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BG590_RS07795	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BG590_RS07800	COG0730	response to heat
BG590_RS07805	COG1214	PFAM Peptidase M22, glycoprotease
BG590_RS07810	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
BG590_RS07815	COG2321	neutral zinc metallopeptidase
BG590_RS07820	COG1674	ftsk spoiiie
BG590_RS07825	COG1522	sequence-specific DNA binding
BG590_RS07830	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
BG590_RS07835	COG1846	Transcriptional regulator
BG590_RS07835	COG1940	carbohydrate kinase activity
BG590_RS07840	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
BG590_RS07845	COG3036	rescue of stalled ribosome
BG590_RS07850	COG2226	methyltransferase
BG590_RS07865	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BG590_RS07870	COG0583	DNA-binding transcription factor activity
BG590_RS07885	COG2969	positive regulation of protein catabolic process
BG590_RS07890	COG0625	glutathione transferase activity
BG590_RS07895	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
BG590_RS07905	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
BG590_RS07915	COG0556	nucleotide-excision repair
BG590_RS07930	COG2837	iron assimilation
BG590_RS07945	COG0613	PHP domain protein
BG590_RS07955	COG2925	Exonuclease
BG590_RS08050	COG1724	mRNA binding
BG590_RS08055	COG1598	PFAM Uncharacterised protein family UPF0150
BG590_RS08115	COG1783	phage Terminase large subunit
BG590_RS08120	COG3728	DNA packaging
BG590_RS08160	COG2801	Transposase and inactivated derivatives
BG590_RS08205	COG0305	Participates in initiation and elongation during chromosome replication
BG590_RS08245	COG2801	Transposase and inactivated derivatives
BG590_RS08370	COG0281	malic enzyme
BG590_RS08370	COG0280	phosphate acetyltransferase
BG590_RS08375	COG0189	ligase activity
BG590_RS08385	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BG590_RS08395	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
BG590_RS08400	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BG590_RS08400	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BG590_RS08460	COG3077	Addiction module antitoxin, RelB DinJ family
BG590_RS08575	COG0629	single-stranded DNA binding
BG590_RS08595	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BG590_RS08595	COG0301	tRNA thio-modification
BG590_RS08605	COG0205	6-phosphofructokinase activity
BG590_RS08610	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BG590_RS08670	COG1525	nuclease
BG590_RS08675	COG1115	amino acid carrier protein
BG590_RS08680	COG0628	permease
BG590_RS08690	COG1678	Uncharacterized ACR, COG1678
BG590_RS08695	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BG590_RS08710	COG0271	Belongs to the BolA IbaG family
BG590_RS08740	COG0494	nUDIX hydrolase
BG590_RS08775	COG1271	oxidase subunit
BG590_RS08780	COG1294	oxidase, subunit
BG590_RS08795	COG0824	Thioesterase
BG590_RS08800	COG0811	peptide transport
BG590_RS08805	COG0848	biopolymer transport protein
BG590_RS08810	COG3064	Membrane
BG590_RS08815	COG0823	Involved in the tonB-independent uptake of proteins
BG590_RS08830	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
BG590_RS08840	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BG590_RS08855	COG0564	pseudouridine synthase activity
BG590_RS08870	COG0488	(ABC) transporter
BG590_RS08880	COG2095	MarC family integral membrane protein
BG590_RS08885	COG0303	'Molybdopterin
BG590_RS08890	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BG590_RS08900	COG3092	negative regulation of chromosome organization
BG590_RS08910	COG2917	probably involved in intracellular septation
BG590_RS08915	COG1607	acyl-coa hydrolase
BG590_RS08920	COG2350	Protein conserved in bacteria
BG590_RS08930	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
BG590_RS08935	COG0732	type I restriction modification DNA specificity domain
BG590_RS08940	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
BG590_RS08960	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BG590_RS08965	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
BG590_RS08970	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
BG590_RS08990	COG3219	Protein conserved in bacteria
BG590_RS09005	COG2259	Doxx family
BG590_RS09010	COG2801	Transposase and inactivated derivatives
BG590_RS09020	COG2801	Transposase and inactivated derivatives
BG590_RS09030	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
BG590_RS09040	COG0681	Belongs to the peptidase S26 family
BG590_RS09050	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
BG590_RS09060	COG0513	Belongs to the DEAD box helicase family
BG590_RS09065	COG0433	COG0433 Predicted ATPase
BG590_RS09070	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
BG590_RS09075	COG3842	ATPase activity
BG590_RS09085	COG1840	ABC-type Fe3 transport system, periplasmic component
BG590_RS09100	COG2194	sulfuric ester hydrolase activity
BG590_RS09105	COG0528	UMP kinase activity
BG590_RS09110	COG0233	cytoplasmic translational termination
BG590_RS09120	COG4942	peptidase
BG590_RS09125	COG2861	carbohydrate metabolic process
BG590_RS09130	COG0729	surface antigen
BG590_RS09135	COG2911	Protein conserved in bacteria
BG590_RS09140	COG4988	ABC transporter
BG590_RS09145	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
BG590_RS09150	COG2915	High frequency lysogenization protein hflD homolog
BG590_RS09155	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BG590_RS09160	COG1349	DNA-binding transcription factor activity
BG590_RS09165	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
BG590_RS09185	COG0187	DNA topoisomerase II activity
BG590_RS09190	COG0500	methyltransferase
BG590_RS09195	COG1944	ATP diphosphatase activity
BG590_RS09215	COG0675	Transposase, IS605 OrfB family
BG590_RS09260	COG1518	maintenance of DNA repeat elements
BG590_RS09270	COG1530	ribonuclease E activity
BG590_RS09275	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BG590_RS09360	COG0740	serine-type endopeptidase activity
BG590_RS09400	COG3179	chitinase
BG590_RS09425	COG1403	HNH endonuclease
BG590_RS09440	COG4626	Terminase
BG590_RS09440	COG1802	Transcriptional regulator
BG590_RS09450	COG4197	protein conserved in bacteria, prophage-related
BG590_RS09495	COG0629	single-stranded DNA binding
BG590_RS09540	COG3617	BRO family, N-terminal domain
BG590_RS09565	COG3392	D12 class N6 adenine-specific DNA methyltransferase
BG590_RS09585	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BG590_RS09590	COG2949	membrane
BG590_RS09595	COG0788	formyltetrahydrofolate deformylase activity
BG590_RS09600	COG2916	Histone family protein nucleoid-structuring protein H-NS
BG590_RS09605	COG1757	Na H antiporter
BG590_RS09610	COG4221	oxidoreductase activity
BG590_RS09620	COG0159	tryptophan synthase activity
BG590_RS09625	COG5339	Protein conserved in bacteria
BG590_RS09630	COG2801	Transposase and inactivated derivatives
BG590_RS09645	COG1598	PFAM Uncharacterised protein family UPF0150
BG590_RS09650	COG1724	mRNA binding
BG590_RS09710	COG0330	HflC and HflK could
BG590_RS09715	COG0330	HflC and HflK could
BG590_RS09730	COG0542	response to heat
BG590_RS09740	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
BG590_RS09745	COG0471	metal ion transport
BG590_RS09750	COG0295	cytidine deaminase activity
BG590_RS09760	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
BG590_RS09770	COG0187	DNA topoisomerase II activity
BG590_RS09785	COG0789	Transcriptional regulator
BG590_RS09790	COG2608	mercury ion transmembrane transporter activity
BG590_RS09805	COG0302	gtp cyclohydrolase
BG590_RS09810	COG3642	lipopolysaccharide core region biosynthetic process
BG590_RS09815	COG0489	protein tyrosine kinase activity
BG590_RS09820	COG4166	transmembrane transport
BG590_RS09825	COG2095	MarC family integral membrane protein
BG590_RS09830	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BG590_RS09835	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BG590_RS09840	COG2354	Protein conserved in bacteria
BG590_RS09845	COG3071	HemY protein
BG590_RS09850	COG2959	enzyme of heme biosynthesis
BG590_RS09860	COG0181	hydroxymethylbilane synthase activity
BG590_RS09865	COG1454	alcohol dehydrogenase
BG590_RS09865	COG1012	belongs to the aldehyde dehydrogenase family
BG590_RS09875	COG0531	amino acid
BG590_RS09885	COG1388	LysM domain
BG590_RS09885	COG0860	N-Acetylmuramoyl-L-alanine amidase
BG590_RS09890	COG0802	atpase or kinase
BG590_RS09895	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
BG590_RS09905	COG1519	Transferase
BG590_RS09910	COG0826	peptidase U32
BG590_RS09925	COG0795	lipopolysaccharide-transporting ATPase activity
BG590_RS09930	COG0795	lipopolysaccharide-transporting ATPase activity
BG590_RS09940	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BG590_RS09945	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BG590_RS09950	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
BG590_RS09965	COG3711	transcriptional antiterminator
BG590_RS09965	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BG590_RS09980	COG3716	PTS system mannose fructose sorbose family IID component
BG590_RS09985	COG3715	PTS system
BG590_RS09990	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BG590_RS09995	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BG590_RS09995	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
BG590_RS10000	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BG590_RS10010	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
BG590_RS10020	COG1902	pentaerythritol trinitrate reductase activity
BG590_RS10030	COG1764	response to oxidative stress
BG590_RS10035	COG2207	Transcriptional regulator
BG590_RS10040	COG0813	purine-nucleoside phosphorylase activity
BG590_RS10050	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BG590_RS10060	COG1216	Glycosyl transferase, family 2
BG590_RS10065	COG1216	Glycosyl transferase, family 2
BG590_RS10075	COG3306	glycosyltransferase involved in LPS biosynthesis
BG590_RS10085	COG2244	polysaccharide biosynthetic process
BG590_RS10100	COG2089	acid synthase
BG590_RS10110	COG1434	Gram-negative-bacterium-type cell wall biogenesis
BG590_RS10115	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BG590_RS10125	COG1280	lysine exporter protein (LysE YggA)
BG590_RS10130	COG2962	Rard protein
BG590_RS10135	COG0436	Aminotransferase
BG590_RS10140	COG1169	isochorismate synthase
BG590_RS10155	COG2801	Transposase and inactivated derivatives
BG590_RS10165	COG0602	queuosine metabolic process
BG590_RS10170	COG0720	synthase
BG590_RS10180	COG2960	long-chain fatty acid transporting porin activity
BG590_RS10185	COG0166	Belongs to the GPI family
BG590_RS10215	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BG590_RS10220	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BG590_RS10230	COG0527	aspartate kinase activity
BG590_RS10230	COG0460	homoserine dehydrogenase
BG590_RS10235	COG0083	homoserine kinase activity
BG590_RS10240	COG0215	cysteine-tRNA ligase activity
BG590_RS10245	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BG590_RS10265	COG0437	4 iron, 4 sulfur cluster binding
BG590_RS10270	COG2864	formate dehydrogenase
BG590_RS10275	COG3058	Necessary for formate dehydrogenase activity
BG590_RS10285	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BG590_RS10295	COG0778	Nitroreductase
BG590_RS10300	COG4172	Belongs to the ABC transporter superfamily
BG590_RS10305	COG0191	fructose-bisphosphate aldolase activity
BG590_RS10310	COG0126	phosphoglycerate kinase activity
BG590_RS10315	COG0733	neurotransmitter:sodium symporter activity
BG590_RS10320	COG0338	D12 class N6 adenine-specific DNA methyltransferase
BG590_RS10325	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
BG590_RS10330	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BG590_RS10340	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
BG590_RS10365	COG4796	Type ii and iii secretion system protein
BG590_RS10370	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BG590_RS10375	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
BG590_RS10380	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
BG590_RS10385	COG1280	lysine exporter protein (LysE YggA)
BG590_RS10390	COG0632	four-way junction helicase activity
BG590_RS10395	COG2255	four-way junction helicase activity
BG590_RS10400	COG4160	amino acid transport
BG590_RS10405	COG4215	(ABC) transporter
BG590_RS10410	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BG590_RS10415	COG1126	abc transporter atp-binding protein
BG590_RS10420	COG4232	protein-disulfide reductase activity
BG590_RS10425	COG3101	peptidyl-lysine hydroxylation
BG590_RS10430	COG1022	Amp-dependent synthetase and ligase
BG590_RS10435	COG0251	oxidation-reduction process
BG590_RS10445	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BG590_RS10450	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
BG590_RS10455	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
BG590_RS10460	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
BG590_RS10470	COG0287	Prephenate dehydrogenase
BG590_RS10470	COG1605	Chorismate mutase
BG590_RS10475	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
BG590_RS10480	COG0859	PFAM glycosyl transferase family 9
BG590_RS10485	COG0469	pyruvate kinase activity
BG590_RS10490	COG2062	phosphohistidine phosphatase, SixA
BG590_RS10495	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BG590_RS10505	COG4771	TonB-dependent receptor
BG590_RS10505	COG1629	transport
BG590_RS10520	COG0346	lactoylglutathione lyase activity
BG590_RS10535	COG2911	Protein conserved in bacteria
BG590_RS10545	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BG590_RS10550	COG0617	tRNA 3'-terminal CCA addition
BG590_RS10555	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
BG590_RS10560	COG4143	(ABC) transporter
BG590_RS10565	COG0402	S-adenosylhomocysteine deaminase activity
BG590_RS10570	COG3753	Protein conserved in bacteria
BG590_RS10580	COG0492	ferredoxin-NADP+ reductase activity
BG590_RS10585	COG2376	Dihydroxyacetone kinase
BG590_RS10590	COG1461	Dihydroxyacetone kinase
BG590_RS10595	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
BG590_RS10595	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BG590_RS10595	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BG590_RS10600	COG3118	belongs to the thioredoxin family
BG590_RS10630	COG3115	cell septum assembly
BG590_RS10650	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BG590_RS10660	COG0475	glutathione-regulated potassium exporter activity
BG590_RS10660	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BG590_RS10670	COG4580	involved in the transport of maltose and maltodextrins
BG590_RS10675	COG3842	ATPase activity
BG590_RS10685	COG1175	transmembrane transport
BG590_RS10690	COG3833	ABC-type maltose transport systems, permease component
BG590_RS10695	COG0366	Alpha amylase catalytic
BG590_RS10700	COG2909	trisaccharide binding
BG590_RS10705	COG0058	SHG alpha-glucan phosphorylase activity
BG590_RS10710	COG1640	4-alpha-glucanotransferase
BG590_RS10720	COG2056	Na+-H+ antiporter family
BG590_RS10725	COG0708	Exodeoxyribonuclease III
BG590_RS10730	COG3117	lipopolysaccharide transmembrane transporter activity
BG590_RS10735	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
BG590_RS10740	COG1137	ATPase activity
BG590_RS10745	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BG590_RS10755	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BG590_RS10770	COG2177	Part of the ABC transporter FtsEX involved in
BG590_RS10775	COG2884	Cell division ATP-binding protein ftsE
BG590_RS10780	COG0552	protein localization to endoplasmic reticulum
BG590_RS10785	COG0742	ribosomal rna small subunit methyltransferase
BG590_RS10790	COG3099	Belongs to the UPF0263 family
BG590_RS10795	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BG590_RS10805	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
BG590_RS10810	COG3326	Membrane
BG590_RS10815	COG1027	Aspartate ammonia-lyase
BG590_RS10820	COG0210	DNA helicase
BG590_RS10825	COG3842	ATPase activity
BG590_RS10830	COG1176	ABC-type spermidine putrescine transport system, permease component I
BG590_RS10835	COG1177	transmembrane transport
BG590_RS10840	COG0601	transmembrane transport
BG590_RS10845	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BG590_RS10850	COG4172	Belongs to the ABC transporter superfamily
BG590_RS10870	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BG590_RS10875	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
BG590_RS10880	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
BG590_RS10885	COG1629	transport
BG590_RS10885	COG4206	TonB-dependent receptor
BG590_RS10890	COG1629	transport
BG590_RS10890	COG4206	TonB-dependent receptor
BG590_RS10900	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BG590_RS10920	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BG590_RS10925	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BG590_RS10930	COG0483	inositol monophosphate 1-phosphatase activity
BG590_RS10935	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BG590_RS10940	COG1966	Carbon starvation protein
BG590_RS10945	COG0084	hydrolase, TatD family'
BG590_RS10970	COG4591	ABC-type transport system involved in lipoprotein release permease component
BG590_RS10975	COG1136	(ABC) transporter
BG590_RS10980	COG4591	ABC-type transport system involved in lipoprotein release permease component
BG590_RS10985	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BG590_RS11015	COG0512	Glutamine amidotransferase of anthranilate synthase
BG590_RS11020	COG1322	Protein conserved in bacteria
BG590_RS11020	COG1322	Protein conserved in bacteria
BG590_RS11030	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BG590_RS11040	COG2137	regulation of response to DNA damage stimulus
BG590_RS11050	COG0551	DNA topoisomerase type I activity
BG590_RS11055	COG0009	L-threonylcarbamoyladenylate synthase
BG590_RS11060	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BG590_RS11085	COG0210	DNA helicase
BG590_RS11090	COG1090	epimerase
BG590_RS11110	COG1666	GTP binding
BG590_RS11115	COG0560	Phosphoserine phosphatase
BG590_RS11125	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
BG590_RS11130	COG2081	HI0933 family
BG590_RS11135	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
BG590_RS11140	COG2252	PERMEase
BG590_RS11145	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BG590_RS11155	COG0716	FMN binding
BG590_RS11160	COG0735	belongs to the Fur family
BG590_RS11165	COG3008	intermembrane lipid transfer
BG590_RS11170	COG1854	S-ribosylhomocysteine lyase activity
BG590_RS11175	COG1132	(ABC) transporter
BG590_RS11180	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BG590_RS11185	COG0592	DNA-directed DNA polymerase activity
BG590_RS11190	COG2976	Protein conserved in bacteria
BG590_RS11200	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
BG590_RS11205	COG1426	Protein conserved in bacteria
BG590_RS11210	COG0165	Argininosuccinate lyase
BG590_RS11230	COG2991	Protein conserved in bacteria
BG590_RS11235	COG1477	protein flavinylation
BG590_RS11240	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
BG590_RS11245	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
BG590_RS11250	COG2871	sodium ion transport
BG590_RS11255	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
BG590_RS11260	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
BG590_RS11265	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
BG590_RS11270	COG1805	sodium ion transport
BG590_RS11280	COG0316	Belongs to the HesB IscA family
BG590_RS11280	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
BG590_RS11290	COG0252	asparaginase activity
BG590_RS11300	COG0583	DNA-binding transcription factor activity
BG590_RS11305	COG1011	Hydrolase
BG590_RS11310	COG0583	DNA-binding transcription factor activity
BG590_RS11315	COG1162	GTPase activity
BG590_RS11325	COG0537	adenosine 5'-monophosphoramidase activity
BG590_RS11335	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BG590_RS11340	COG3108	Peptidase M15
BG590_RS11345	COG2989	Protein conserved in bacteria
BG590_RS11350	COG0793	Belongs to the peptidase S41A family
BG590_RS11355	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
BG590_RS11365	COG2814	Major facilitator Superfamily
BG590_RS11370	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BG590_RS11380	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BG590_RS11410	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
BG590_RS11415	COG0792	nuclease activity
BG590_RS11420	COG3107	peptidoglycan biosynthetic process
BG590_RS11440	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BG590_RS11445	COG1414	Transcriptional regulator
BG590_RS11450	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BG590_RS11460	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
BG590_RS11475	COG3068	Protein conserved in bacteria
BG590_RS11490	COG1530	ribonuclease E activity
BG590_RS11500	COG1917	Cupin 2, conserved barrel domain protein
BG590_RS11500	COG4977	sequence-specific DNA binding
BG590_RS11510	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
BG590_RS11515	COG2824	Alkylphosphonate utilization operon protein PhnA
BG590_RS11520	COG0557	exoribonuclease II activity
BG590_RS11540	COG3116	cell division
BG590_RS11545	COG0768	penicillin binding
BG590_RS11550	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BG590_RS11555	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BG590_RS11560	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BG590_RS11565	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BG590_RS11570	COG0772	Belongs to the SEDS family
BG590_RS11575	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BG590_RS11585	COG1181	Belongs to the D-alanine--D-alanine ligase family
BG590_RS11595	COG0849	cell division
BG590_RS11610	COG0497	DNA recombination
BG590_RS11675	COG1652	LysM domain
BG590_RS11680	COG2927	DNA polymerase III (CHI subunit)
BG590_RS11685	COG2153	protein acetylation
BG590_RS11695	COG4185	zeta toxin
BG590_RS11705	COG0525	valine-tRNA ligase activity
BG590_RS11715	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
BG590_RS11720	COG1794	racemase activity, acting on amino acids and derivatives
BG590_RS11730	COG0363	glucosamine-6-phosphate deaminase activity
BG590_RS11735	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BG590_RS11740	COG1218	3'(2'),5'-bisphosphate nucleotidase
BG590_RS11745	COG0494	nUDIX hydrolase
BG590_RS11750	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
BG590_RS11770	COG0107	imidazoleglycerol-phosphate synthase activity
BG590_RS11785	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
BG590_RS11800	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
BG590_RS11800	COG0131	Imidazoleglycerol-phosphate dehydratase
BG590_RS11825	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
BG590_RS11830	COG0456	acetyltransferase
BG590_RS11835	COG1217	gtp-binding protein TYPA
BG590_RS11845	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
BG590_RS11870	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BG590_RS11880	COG0582	viral genome integration into host DNA
BG590_RS11905	COG3728	DNA packaging
BG590_RS11915	COG1045	serine acetyltransferase
BG590_RS11920	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
BG590_RS11925	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
BG590_RS11930	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BG590_RS11935	COG0544	peptidyl-prolyl cis-trans isomerase activity
BG590_RS11945	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BG590_RS11950	COG0049	tRNA binding
BG590_RS11955	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BG590_RS11960	COG0859	PFAM glycosyl transferase family 9
BG590_RS11965	COG0859	PFAM glycosyl transferase family 9
BG590_RS11975	COG3061	Opacity-associated protein A
BG590_RS11975	COG3266	domain, Protein
BG590_RS11980	COG1555	photosystem II stabilization
BG590_RS11985	COG0688	phosphatidylethanolamine metabolic process
BG590_RS12010	COG4974	Belongs to the 'phage' integrase family
BG590_RS12025	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BG590_RS12025	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
BG590_RS12030	COG3715	PTS system
BG590_RS12035	COG3716	PTS system mannose fructose sorbose family IID component
BG590_RS12055	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
BG590_RS12060	COG1238	metal cluster binding
BG590_RS12075	COG4942	peptidase
BG590_RS12075	COG1388	LysM domain
BG590_RS12085	COG2818	Glycosylase
BG590_RS12095	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BG590_RS12105	COG0257	Belongs to the bacterial ribosomal protein bL36 family
BG590_RS12110	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BG590_RS12115	COG0765	amino acid transport
BG590_RS12120	COG1126	abc transporter atp-binding protein
BG590_RS12125	COG0762	integral membrane protein
BG590_RS12135	COG3171	Protein conserved in bacteria
BG590_RS12140	COG0220	tRNA (guanine-N7-)-methyltransferase activity
BG590_RS12145	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BG590_RS12155	COG0805	protein transport
BG590_RS12160	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BG590_RS12165	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BG590_RS12170	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BG590_RS12175	COG4804	nuclease activity
BG590_RS12180	COG3165	ubiquinone biosynthetic process from chorismate
BG590_RS12185	COG2226	methyltransferase
BG590_RS12190	COG0598	Magnesium transport protein CorA
BG590_RS12205	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
BG590_RS12210	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BG590_RS12215	COG0783	Belongs to the Dps family
BG590_RS12225	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
BG590_RS12235	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
BG590_RS12240	COG2259	Doxx family
BG590_RS12245	COG1040	competence protein
BG590_RS12250	COG0561	phosphatase activity
BG590_RS12255	COG0697	spore germination
BG590_RS12260	COG0697	spore germination
BG590_RS12270	COG0261	This protein binds to 23S rRNA in the presence of protein L20
BG590_RS12275	COG0142	geranyltranstransferase activity
BG590_RS12280	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BG590_RS12285	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
BG590_RS12295	COG1028	Short-chain dehydrogenase reductase Sdr
BG590_RS12300	COG1114	Component of the transport system for branched-chain amino acids
BG590_RS12310	COG1490	D-aminoacyl-tRNA deacylase activity
BG590_RS12315	COG1295	ribonuclease BN
BG590_RS12330	COG3041	Addiction module toxin RelE StbE family
BG590_RS12335	COG3077	Addiction module antitoxin, RelB DinJ family
BG590_RS12350	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BG590_RS12370	COG0347	Belongs to the P(II) protein family
BG590_RS12390	COG0753	catalase activity
BG590_RS12395	COG0425	Belongs to the sulfur carrier protein TusA family
BG590_RS12400	COG2391	methyltransferase activity
BG590_RS12410	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BG590_RS12415	COG1393	Belongs to the ArsC family
BG590_RS12420	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
BG590_RS12425	COG0564	pseudouridine synthase activity
BG590_RS12430	COG0668	transmembrane transport
BG590_RS12435	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
BG590_RS12445	COG0431	NADPH-dependent FMN reductase
BG590_RS12455	COG1902	pentaerythritol trinitrate reductase activity
BG590_RS12460	COG0778	Nitroreductase
BG590_RS12490	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BG590_RS12495	COG1064	alcohol dehydrogenase
BG590_RS12500	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
BG590_RS12515	COG0494	nUDIX hydrolase
BG590_RS12520	COG0730	response to heat
BG590_RS12530	COG0546	phosphoglycolate phosphatase activity
BG590_RS12545	COG0180	Tryptophanyl-tRNA synthetase
BG590_RS12550	COG0501	Belongs to the peptidase M48B family
BG590_RS12555	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
BG590_RS12575	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BG590_RS12580	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
BG590_RS12585	COG0470	DNA polymerase III
BG590_RS12600	COG0084	hydrolase, TatD family'
BG590_RS12610	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BG590_RS12640	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
BG590_RS12645	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
BG590_RS12650	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BG590_RS12655	COG1053	succinate dehydrogenase
BG590_RS12660	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
BG590_RS12665	COG2962	Rard protein
BG590_RS12670	COG2223	nitrite transmembrane transporter activity
BG590_RS12680	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BG590_RS12685	COG2020	methyltransferase activity
BG590_RS12690	COG0728	peptidoglycan biosynthetic process
BG590_RS12695	COG0268	Binds directly to 16S ribosomal RNA
BG590_RS12700	COG1970	mechanosensitive ion channel activity
BG590_RS12705	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
BG590_RS12710	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BG590_RS12715	COG1739	Uncharacterized protein family UPF0029
BG590_RS12725	COG1119	ATPase activity
BG590_RS12735	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BG590_RS12745	COG2801	Transposase and inactivated derivatives
BG590_RS12750	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
BG590_RS12755	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BG590_RS12760	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
BG590_RS12765	COG0321	lipoyl(octanoyl) transferase activity
BG590_RS12770	COG2921	Belongs to the UPF0250 family
BG590_RS12775	COG1686	Belongs to the peptidase S11 family
BG590_RS12780	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
BG590_RS12785	COG0772	Belongs to the SEDS family
BG590_RS12790	COG0768	penicillin binding
BG590_RS12800	COG0799	negative regulation of ribosome biogenesis
BG590_RS12810	COG1312	Catalyzes the dehydration of D-mannonate
BG590_RS12815	COG2186	Transcriptional regulator
BG590_RS12820	COG1063	alcohol dehydrogenase
BG590_RS12825	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BG590_RS12830	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
BG590_RS12835	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BG590_RS12840	COG1028	Short-chain dehydrogenase reductase Sdr
BG590_RS12845	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BG590_RS12850	COG0800	Aldolase
BG590_RS12855	COG4783	chaperone-mediated protein folding
BG590_RS12875	COG0545	Peptidyl-prolyl cis-trans isomerase
BG590_RS12880	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BG590_RS12890	COG3676	manually curated
BG590_RS12900	COG0037	tRNA processing
BG590_RS12905	COG4974	Belongs to the 'phage' integrase family
BG590_RS12940	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BG590_RS12965	COG3133	Outer membrane lipoprotein
BG590_RS12970	COG3102	Protein conserved in bacteria
BG590_RS12975	COG0018	arginyl-trna synthetase
BG590_RS12980	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BG590_RS12990	COG1138	Cytochrome C-type biogenesis protein
BG590_RS13000	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BG590_RS13005	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BG590_RS13010	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BG590_RS13015	COG4133	protoheme IX ABC transporter activity
BG590_RS13020	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BG590_RS13025	COG0747	negative chemotaxis
BG590_RS13030	COG0601	transmembrane transport
BG590_RS13035	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BG590_RS13040	COG0444	Belongs to the ABC transporter superfamily
BG590_RS13045	COG4608	Belongs to the ABC transporter superfamily
BG590_RS13055	COG1595	DNA-templated transcription, initiation
BG590_RS13060	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BG590_RS13060	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BG590_RS13065	COG2801	Transposase and inactivated derivatives
BG590_RS13075	COG0616	signal peptide processing
BG590_RS13090	COG2801	Transposase and inactivated derivatives
BG590_RS13140	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
BG590_RS13155	COG0174	glutamine synthetase
BG590_RS13170	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
BG590_RS13180	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BG590_RS13200	COG0085	RNA polymerase activity
BG590_RS13215	COG2168	tRNA wobble position uridine thiolation
BG590_RS13225	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
BG590_RS13230	COG2964	Protein conserved in bacteria
BG590_RS13235	COG0545	Peptidyl-prolyl cis-trans isomerase
BG590_RS13240	COG2900	Belongs to the SlyX family
BG590_RS13255	COG3914	O-linked N-acetylglucosamine transferase SPINDLY family
BG590_RS13265	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
BG590_RS13270	COG1328	CTP reductase activity
BG590_RS13285	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BG590_RS13295	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BG590_RS13305	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BG590_RS13310	COG1028	Short-chain dehydrogenase reductase Sdr
BG590_RS13325	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BG590_RS13340	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BG590_RS13350	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BG590_RS13370	COG0758	DNA mediated transformation
BG590_RS13385	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BG590_RS13390	COG1067	ATP-dependent peptidase activity
BG590_RS13395	COG3120	sequence-specific DNA binding
BG590_RS13405	COG0247	lactate metabolic process
BG590_RS13405	COG0277	FAD linked oxidase domain protein
BG590_RS13410	COG2050	protein possibly involved in aromatic compounds catabolism
BG590_RS13425	COG0204	Acyl-transferase
BG590_RS13435	COG0825	malonyl-CoA metabolic process
BG590_RS13455	COG0235	Class ii aldolase
BG590_RS13460	COG3623	hexulose-6-phosphate isomerase
BG590_RS13480	COG0737	Belongs to the 5'-nucleotidase family
BG590_RS13500	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
BG590_RS13505	COG1929	Belongs to the glycerate kinase type-1 family
BG590_RS13510	COG2610	gluconate transmembrane transporter activity
BG590_RS13515	COG3835	regulator
BG590_RS13535	COG0840	transmembrane signaling receptor activity
BG590_RS13575	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
BG590_RS13585	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
BG590_RS13595	COG0089	rRNA binding
BG590_RS13600	COG0088	Forms part of the polypeptide exit tunnel
BG590_RS13605	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BG590_RS13610	COG0051	transcription antitermination factor activity, RNA binding
BG590_RS13615	COG3070	regulator of competence-specific genes
BG590_RS13630	COG0019	diaminopimelate decarboxylase activity
BG590_RS13635	COG0625	glutathione transferase activity
BG590_RS13645	COG2264	protein methyltransferase activity
BG590_RS13700	COG3161	chorismate lyase activity
BG590_RS13710	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
BG590_RS13730	COG0442	prolyl-tRNA aminoacylation
BG590_RS13750	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BG590_RS13760	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BG590_RS13765	COG1192	Involved in chromosome partitioning
BG590_RS13780	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
BG590_RS13785	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
BG590_RS13835	COG3012	SEC-C Motif Domain Protein