locus-tag	class	description
BG553_RS00005	COG0445	tRNA wobble uridine modification
BG553_RS00015	COG0357	Ribosomal RNA small subunit methyltransferase G
BG553_RS00030	COG0667	Aldo Keto reductase
BG553_RS00035	COG2271	Major facilitator Superfamily
BG553_RS00040	COG0584	glycerophosphoryl diester phosphodiesterase
BG553_RS00045	COG2271	Major facilitator Superfamily
BG553_RS00090	COG1129	ABC transporter
BG553_RS00095	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BG553_RS00100	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BG553_RS00105	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BG553_RS00110	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
BG553_RS00115	COG2731	YhcH YjgK YiaL family protein
BG553_RS00120	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
BG553_RS00155	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BG553_RS00160	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BG553_RS00185	COG2502	aspartate--ammonia ligase
BG553_RS00190	COG1522	sequence-specific DNA binding
BG553_RS00200	COG0716	FMN binding
BG553_RS00205	COG0747	negative chemotaxis
BG553_RS00230	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
BG553_RS00245	COG0259	pyridoxamine-phosphate oxidase activity
BG553_RS00255	COG3276	selenocysteine insertion sequence binding
BG553_RS00260	COG2358	TRAP transporter, solute receptor (TAXI family
BG553_RS00275	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BG553_RS00280	COG0569	domain protein
BG553_RS00285	COG3477	response to acidic pH
BG553_RS00290	COG1012	belongs to the aldehyde dehydrogenase family
BG553_RS00295	COG1454	alcohol dehydrogenase
BG553_RS00300	COG1263	PTS System
BG553_RS00300	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BG553_RS00305	COG1879	ABC-type sugar transport system periplasmic component
BG553_RS00310	COG1172	Belongs to the binding-protein-dependent transport system permease family
BG553_RS00315	COG1129	ABC transporter
BG553_RS00320	COG0235	Class ii aldolase
BG553_RS00325	COG4154	Belongs to the RbsD FucU family
BG553_RS00330	COG1070	Carbohydrate kinase
BG553_RS00335	COG2407	Converts the aldose L-fucose into the corresponding ketose L-fuculose
BG553_RS00340	COG1349	DNA-binding transcription factor activity
BG553_RS00380	COG1629	transport
BG553_RS00380	COG4206	TonB-dependent receptor
BG553_RS00400	COG3676	manually curated
BG553_RS00410	COG1757	Na H antiporter
BG553_RS00415	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BG553_RS00430	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
BG553_RS00435	COG1595	DNA-templated transcription, initiation
BG553_RS00450	COG0673	inositol 2-dehydrogenase activity
BG553_RS00455	COG1305	Transglutaminase-like
BG553_RS00465	COG2608	mercury ion transmembrane transporter activity
BG553_RS00470	COG3730	PTS system glucitol sorbitol-specific
BG553_RS00485	COG1028	Short-chain dehydrogenase reductase Sdr
BG553_RS00490	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
BG553_RS00495	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BG553_RS00500	COG1349	DNA-binding transcription factor activity
BG553_RS00505	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
BG553_RS00505	COG0517	IMP dehydrogenase activity
BG553_RS00525	COG3722	fumarate hydratase activity
BG553_RS00530	COG0471	metal ion transport
BG553_RS00530	COG0490	domain, Protein
BG553_RS00535	COG4214	carbohydrate transport
BG553_RS00540	COG1129	ABC transporter
BG553_RS00545	COG4213	ABC transporter substrate-binding protein
BG553_RS00550	COG2115	Belongs to the xylose isomerase family
BG553_RS00555	COG1070	Carbohydrate kinase
BG553_RS00565	COG3545	Serine hydrolase
BG553_RS00575	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
BG553_RS00580	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BG553_RS00585	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BG553_RS00590	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
BG553_RS00605	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BG553_RS00610	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BG553_RS00665	COG0697	spore germination
BG553_RS00670	COG0346	lactoylglutathione lyase activity
BG553_RS00675	COG1194	a g-specific adenine glycosylase
BG553_RS00680	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
BG553_RS00685	COG0741	lytic transglycosylase activity
BG553_RS00710	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BG553_RS00715	COG1349	DNA-binding transcription factor activity
BG553_RS00720	COG2084	Dehydrogenase
BG553_RS00725	COG3395	kinase activity
BG553_RS00730	COG0235	Class ii aldolase
BG553_RS00735	COG3622	Belongs to the hyi family
BG553_RS00740	COG2610	gluconate transmembrane transporter activity
BG553_RS00750	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
BG553_RS00775	COG4545	Glutaredoxin-related protein
BG553_RS00780	COG4804	nuclease activity
BG553_RS00805	COG2964	Protein conserved in bacteria
BG553_RS00820	COG2832	Protein of unknown function (DUF454)
BG553_RS00840	COG3085	chromosome segregation
BG553_RS00845	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
BG553_RS00855	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BG553_RS00865	COG0521	Mo-molybdopterin cofactor biosynthetic process
BG553_RS00885	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BG553_RS00930	COG1840	ABC-type Fe3 transport system, periplasmic component
BG553_RS00940	COG1349	DNA-binding transcription factor activity
BG553_RS00945	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BG553_RS00965	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BG553_RS00975	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
BG553_RS00985	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
BG553_RS00995	COG0200	Binds to the 23S rRNA
BG553_RS01000	COG0201	protein transport
BG553_RS01010	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
BG553_RS01020	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BG553_RS01025	COG0202	RNA polymerase activity
BG553_RS01030	COG0203	ribosomal protein L17
BG553_RS01035	COG1609	Transcriptional regulator
BG553_RS01035	COG2207	Transcriptional regulator
BG553_RS01040	COG1609	Transcriptional regulator
BG553_RS01045	COG3265	gluconokinase activity
BG553_RS01050	COG2610	gluconate transmembrane transporter activity
BG553_RS01065	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
BG553_RS01070	COG1012	belongs to the aldehyde dehydrogenase family
BG553_RS01075	COG3718	enzyme involved in inositol metabolism
BG553_RS01090	COG1129	ABC transporter
BG553_RS01095	COG1172	Belongs to the binding-protein-dependent transport system permease family
BG553_RS01100	COG0673	inositol 2-dehydrogenase activity
BG553_RS01115	COG0673	inositol 2-dehydrogenase activity
BG553_RS01125	COG3962	Belongs to the TPP enzyme family
BG553_RS01140	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BG553_RS01150	COG1263	PTS System
BG553_RS01150	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BG553_RS01150	COG2190	(PTS) system
BG553_RS01155	COG0228	four-way junction DNA binding
BG553_RS01160	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BG553_RS01165	COG0336	Belongs to the RNA methyltransferase TrmD family
BG553_RS01185	COG1694	Mazg nucleotide pyrophosphohydrolase
BG553_RS01190	COG2850	peptidyl-arginine hydroxylation
BG553_RS01195	COG0439	Biotin carboxylase
BG553_RS01200	COG0511	ligase activity, forming carbon-carbon bonds
BG553_RS01210	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
BG553_RS01225	COG1876	peptidase activity
BG553_RS01235	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
BG553_RS01240	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BG553_RS01250	COG0606	chelatase, subunit chli
BG553_RS01255	COG2267	carboxylic ester hydrolase activity
BG553_RS01285	COG3691	Protein conserved in bacteria
BG553_RS01295	COG1879	ABC-type sugar transport system periplasmic component
BG553_RS01300	COG1879	ABC-type sugar transport system periplasmic component
BG553_RS01310	COG4211	Belongs to the binding-protein-dependent transport system permease family
BG553_RS01330	COG4795	General secretion pathway protein
BG553_RS01345	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
BG553_RS01355	COG0747	negative chemotaxis
BG553_RS01380	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
BG553_RS01380	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
BG553_RS01385	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BG553_RS01400	COG1309	transcriptional regulator
BG553_RS01425	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BG553_RS01430	COG2003	Belongs to the UPF0758 family
BG553_RS01445	COG1349	DNA-binding transcription factor activity
BG553_RS01460	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
BG553_RS01465	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
BG553_RS01470	COG0076	glutamate decarboxylase activity
BG553_RS01475	COG3111	PFAM Bacterial OB fold (BOF) protein
BG553_RS01480	COG2249	NAD(P)H dehydrogenase (quinone) activity
BG553_RS01485	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
BG553_RS01490	COG3062	negative regulation of establishment of protein localization
BG553_RS01495	COG0243	molybdopterin cofactor binding
BG553_RS01500	COG0437	4 iron, 4 sulfur cluster binding
BG553_RS01505	COG0348	domain, Protein
BG553_RS01510	COG3043	anaerobic respiration
BG553_RS01515	COG3005	denitrification pathway
BG553_RS01520	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
BG553_RS01530	COG3005	denitrification pathway
BG553_RS01540	COG3381	protein complex oligomerization
BG553_RS01560	COG0494	nUDIX hydrolase
BG553_RS01580	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
BG553_RS01585	COG4145	pantothenate transmembrane transporter activity
BG553_RS01590	COG3924	membrane
BG553_RS01595	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
BG553_RS01600	COG2853	Lipoprotein
BG553_RS01605	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BG553_RS01615	COG1858	cytochrome C peroxidase
BG553_RS01640	COG2801	Transposase and inactivated derivatives
BG553_RS01660	COG1309	transcriptional regulator
BG553_RS01665	COG0583	DNA-binding transcription factor activity
BG553_RS01670	COG0678	peroxiredoxin activity
BG553_RS01670	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
BG553_RS01675	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
BG553_RS01680	COG1803	Methylglyoxal synthase
BG553_RS01685	COG1289	transmembrane transporter activity
BG553_RS01690	COG1943	Transposase
BG553_RS01695	COG2995	paraquat-inducible protein a
BG553_RS01700	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
BG553_RS01720	COG0416	fatty acid biosynthetic process
BG553_RS01730	COG1399	metal-binding, possibly nucleic acid-binding protein
BG553_RS01735	COG4137	Cytochrome C assembly protein
BG553_RS01740	COG4536	flavin adenine dinucleotide binding
BG553_RS01745	COG0733	neurotransmitter:sodium symporter activity
BG553_RS01755	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
BG553_RS01760	COG0513	Belongs to the DEAD box helicase family
BG553_RS01765	COG2801	Transposase and inactivated derivatives
BG553_RS01780	COG3423	Transcriptional regulator
BG553_RS01785	COG2932	Transcriptional regulator
BG553_RS01795	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
BG553_RS01800	COG0676	glucose-6-phosphate 1-epimerase activity
BG553_RS01810	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
BG553_RS01815	COG0024	Methionine aminopeptidase
BG553_RS01825	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
BG553_RS01830	COG1178	ABC-type Fe3 transport system permease component
BG553_RS01835	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BG553_RS01840	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BG553_RS01845	COG2190	(PTS) system
BG553_RS01850	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BG553_RS01855	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BG553_RS01860	COG1621	beta-fructofuranosidase activity
BG553_RS01875	COG1758	RNA polymerase activity
BG553_RS01880	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BG553_RS01895	COG0230	Belongs to the bacterial ribosomal protein bL34 family
BG553_RS01900	COG0594	ribonuclease P activity
BG553_RS01905	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
BG553_RS01925	COG0562	UDP-galactopyranose mutase
BG553_RS01960	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BG553_RS01970	COG1575	Belongs to the MenA family. Type 1 subfamily
BG553_RS01975	COG1720	tRNA m6t6A37 methyltransferase activity
BG553_RS01985	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BG553_RS01990	COG1047	Peptidyl-prolyl cis-trans
BG553_RS02000	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BG553_RS02005	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
BG553_RS02010	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BG553_RS02020	COG0745	RESPONSE REGULATOR receiver
BG553_RS02025	COG2129	metallophosphoesterase
BG553_RS02030	COG3172	ATPase kinase involved in NAD metabolism
BG553_RS02035	COG0196	riboflavin kinase activity
BG553_RS02040	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
BG553_RS02055	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BG553_RS02060	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BG553_RS02065	COG4172	Belongs to the ABC transporter superfamily
BG553_RS02070	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BG553_RS02075	COG0601	transmembrane transport
BG553_RS02080	COG0747	negative chemotaxis
BG553_RS02090	COG1686	Belongs to the peptidase S11 family
BG553_RS02105	COG1620	l-lactate permease
BG553_RS02110	COG0247	lactate metabolic process
BG553_RS02115	COG1139	Iron-sulfur cluster binding protein
BG553_RS02120	COG1556	Lactate utilization protein
BG553_RS02135	COG1561	YicC-like family, N-terminal region
BG553_RS02140	COG0354	folic acid binding
BG553_RS02145	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
BG553_RS02155	COG1129	ABC transporter
BG553_RS02160	COG1172	Belongs to the binding-protein-dependent transport system permease family
BG553_RS02165	COG1879	ABC-type sugar transport system periplasmic component
BG553_RS02170	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BG553_RS02175	COG1609	Transcriptional regulator
BG553_RS02180	COG2197	response regulator
BG553_RS02190	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
BG553_RS02205	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
BG553_RS02215	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BG553_RS02220	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
BG553_RS02225	COG5016	pyruvate
BG553_RS02225	COG0511	ligase activity, forming carbon-carbon bonds
BG553_RS02230	COG3630	sodium ion export across plasma membrane
BG553_RS02235	COG1914	H( )-stimulated, divalent metal cation uptake system
BG553_RS02240	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
BG553_RS02245	COG1984	allophanate hydrolase subunit 2
BG553_RS02250	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
BG553_RS02255	COG1793	dna ligase
BG553_RS02305	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
BG553_RS02315	COG0006	proline dipeptidase activity
BG553_RS02320	COG3030	protein affecting phage T7 exclusion by the F plasmid
BG553_RS02330	COG1187	pseudouridine synthase activity
BG553_RS02345	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BG553_RS02355	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BG553_RS02360	COG5413	integral membrane protein
BG553_RS02380	COG4166	transmembrane transport
BG553_RS02385	COG1254	Belongs to the acylphosphatase family
BG553_RS02390	COG0308	aminopeptidase N
BG553_RS02395	COG0748	coenzyme F420 binding
BG553_RS02410	COG0814	amino acid
BG553_RS02415	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BG553_RS02435	COG1487	ribonuclease activity
BG553_RS02440	COG2195	Cleaves the N-terminal amino acid of tripeptides
BG553_RS02475	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BG553_RS02480	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BG553_RS02485	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BG553_RS02490	COG1121	(ABC) transporter
BG553_RS02515	COG3063	Type IV pilus biogenesis stability protein PilW
BG553_RS02520	COG2183	response to ionizing radiation
BG553_RS02525	COG0778	Nitroreductase
BG553_RS02530	COG0616	signal peptide processing
BG553_RS02555	COG0477	Major facilitator Superfamily
BG553_RS02575	COG3978	acetolactate synthase activity
BG553_RS02590	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
BG553_RS02595	COG0437	4 iron, 4 sulfur cluster binding
BG553_RS02600	COG3301	Polysulphide reductase, NrfD
BG553_RS02605	COG1138	Cytochrome C-type biogenesis protein
BG553_RS02610	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BG553_RS02615	COG4235	cytochrome complex assembly
BG553_RS02615	COG3088	subunit of a heme lyase
BG553_RS02625	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BG553_RS02630	COG1127	ABC transporter
BG553_RS02635	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BG553_RS02640	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
BG553_RS02645	COG2854	intermembrane phospholipid transfer
BG553_RS02655	COG5007	Belongs to the BolA IbaG family
BG553_RS02660	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BG553_RS02665	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
BG553_RS02680	COG0494	nUDIX hydrolase
BG553_RS02705	COG2431	L-lysine efflux transmembrane transporter activity
BG553_RS02715	COG0501	Belongs to the peptidase M48B family
BG553_RS02720	COG1238	metal cluster binding
BG553_RS02725	COG2116	formate transmembrane transporter activity
BG553_RS02730	COG1882	Formate acetyltransferase
BG553_RS02740	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
BG553_RS02745	COG0339	signal peptide processing
BG553_RS02750	COG1605	Chorismate mutase
BG553_RS02750	COG0077	Prephenate dehydratase
BG553_RS02755	COG2841	Protein conserved in bacteria
BG553_RS02760	COG2268	Band 7 protein
BG553_RS02765	COG2801	Transposase and inactivated derivatives
BG553_RS02780	COG4773	Receptor
BG553_RS02785	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BG553_RS02795	COG1120	ATPase activity
BG553_RS02800	COG2814	Major facilitator Superfamily
BG553_RS02830	COG1120	ATPase activity
BG553_RS02835	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BG553_RS02850	COG4206	TonB-dependent receptor
BG553_RS02855	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
BG553_RS02875	COG1663	tetraacyldisaccharide 4'-kinase activity
BG553_RS02900	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
BG553_RS02905	COG0740	serine-type endopeptidase activity
BG553_RS02910	COG2166	iron-sulfur cluster assembly
BG553_RS02920	COG2226	methyltransferase
BG553_RS02930	COG1942	4-Oxalocrotonate Tautomerase
BG553_RS02935	COG0512	Glutamine amidotransferase of anthranilate synthase
BG553_RS02940	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BG553_RS02945	COG0009	L-threonylcarbamoyladenylate synthase
BG553_RS02950	COG1187	pseudouridine synthase activity
BG553_RS02955	COG3273	potassium ion transport
BG553_RS02955	COG0471	metal ion transport
BG553_RS02970	COG1640	4-alpha-glucanotransferase
BG553_RS02995	COG2965	DNA replication, synthesis of RNA primer
BG553_RS03015	COG0488	(ABC) transporter
BG553_RS03040	COG4657	Part of a membrane complex involved in electron transport
BG553_RS03045	COG2878	Part of a membrane complex involved in electron transport
BG553_RS03050	COG4656	Part of a membrane complex involved in electron transport
BG553_RS03055	COG2860	membrane
BG553_RS03060	COG4658	electron transport chain
BG553_RS03080	COG1560	Kdo2-lipid A biosynthetic process
BG553_RS03085	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BG553_RS03090	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
BG553_RS03095	COG1131	(ABC) transporter
BG553_RS03100	COG0842	Transport permease protein
BG553_RS03105	COG0725	ABC transporter, periplasmic molybdate-binding protein
BG553_RS03115	COG4149	molybdate abc transporter
BG553_RS03120	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
BG553_RS03125	COG2867	negative regulation of translational initiation
BG553_RS03130	COG2914	Belongs to the UPF0125 (RnfH) family
BG553_RS03140	COG2195	Cleaves the N-terminal amino acid of tripeptides
BG553_RS03155	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
BG553_RS03160	COG0194	GDP metabolic process
BG553_RS03165	COG1538	Outer membrane efflux protein
BG553_RS03170	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
BG553_RS03225	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BG553_RS03235	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BG553_RS03245	COG0732	type I restriction modification DNA specificity domain
BG553_RS03260	COG0488	(ABC) transporter
BG553_RS03265	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
BG553_RS03270	COG1611	Belongs to the LOG family
BG553_RS03275	COG3593	DNA synthesis involved in DNA repair
BG553_RS03280	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BG553_RS03310	COG4667	esterase of the alpha-beta hydrolase superfamily
BG553_RS03320	COG3719	Belongs to the RNase T2 family
BG553_RS03330	COG1252	NADH dehydrogenase
BG553_RS03335	COG1840	ABC-type Fe3 transport system, periplasmic component
BG553_RS03350	COG2252	PERMEase
BG553_RS03355	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BG553_RS03360	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BG553_RS03365	COG1862	Preprotein translocase
BG553_RS03370	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
BG553_RS03375	COG2017	converts alpha-aldose to the beta-anomer
BG553_RS03380	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
BG553_RS03385	COG1085	galactose-1-phosphate uridylyltransferase
BG553_RS03390	COG3739	integral membrane protein
BG553_RS03395	COG1408	metallophosphoesterase
BG553_RS03425	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BG553_RS03440	COG2801	Transposase and inactivated derivatives
BG553_RS03470	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BG553_RS03475	COG2233	PERMEase
BG553_RS03480	COG0167	dihydroorotate dehydrogenase activity
BG553_RS03485	COG4316	Uncharacterized protein conserved in bacteria (DUF2251)
BG553_RS03490	COG0148	phosphopyruvate hydratase activity
BG553_RS03495	COG2932	Transcriptional regulator
BG553_RS03500	COG3423	Transcriptional regulator
BG553_RS03510	COG2842	Transposition protein
BG553_RS03535	COG4396	Host-nuclease inhibitor protein Gam
BG553_RS03560	COG4382	Mu-like prophage protein Gp16
BG553_RS03565	COG3561	AntA/AntB antirepressor
BG553_RS03620	COG4383	Mu-like prophage protein gp29
BG553_RS03625	COG2369	cell adhesion
BG553_RS03630	COG5005	Phage virion morphogenesis
BG553_RS03645	COG4397	Mu-like prophage major head subunit gpT
BG553_RS03715	COG3299	homolog of phage Mu protein gp47
BG553_RS03740	COG3392	D12 class N6 adenine-specific DNA methyltransferase
BG553_RS03770	COG0277	FAD linked oxidase domain protein
BG553_RS03810	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BG553_RS03815	COG1472	Belongs to the glycosyl hydrolase 3 family
BG553_RS03820	COG0861	Integral membrane protein TerC family
BG553_RS03840	COG1584	GPR1 FUN34 yaaH family protein
BG553_RS03850	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BG553_RS03870	COG1263	PTS System
BG553_RS03870	COG2190	(PTS) system
BG553_RS03870	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BG553_RS03885	COG2920	part of a sulfur-relay system
BG553_RS03890	COG0670	Belongs to the BI1 family
BG553_RS03895	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BG553_RS03910	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
BG553_RS03915	COG0291	Belongs to the bacterial ribosomal protein bL35 family
BG553_RS03920	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BG553_RS03930	COG1965	Belongs to the frataxin family
BG553_RS03945	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BG553_RS03950	COG0564	pseudouridine synthase activity
BG553_RS03960	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
BG553_RS03965	COG1560	Kdo2-lipid A biosynthetic process
BG553_RS03970	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BG553_RS03975	COG0814	amino acid
BG553_RS03980	COG1760	l-serine dehydratase
BG553_RS03995	COG2027	D-alanyl-D-alanine carboxypeptidase
BG553_RS04000	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BG553_RS04015	COG1441	menaquinone biosynthetic process
BG553_RS04025	COG2814	Major facilitator Superfamily
BG553_RS04030	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BG553_RS04035	COG0232	Belongs to the dGTPase family. Type 2 subfamily
BG553_RS04060	COG0564	pseudouridine synthase activity
BG553_RS04065	COG3023	N-Acetylmuramoyl-L-alanine amidase
BG553_RS04070	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
BG553_RS04085	COG0626	cystathionine gamma-synthase activity
BG553_RS04090	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
BG553_RS04105	COG1702	phosphate starvation-inducible protein PhoH
BG553_RS04130	COG0583	DNA-binding transcription factor activity
BG553_RS04135	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
BG553_RS04160	COG0815	Transfers the fatty acyl group on membrane lipoproteins
BG553_RS04180	COG2801	Transposase and inactivated derivatives
BG553_RS04190	COG3381	protein complex oligomerization
BG553_RS04200	COG0791	NLP P60 protein
BG553_RS04205	COG2932	Transcriptional regulator
BG553_RS04215	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
BG553_RS04220	COG0330	HflC and HflK could
BG553_RS04230	COG2990	Protein conserved in bacteria
BG553_RS04240	COG1643	Atp-dependent helicase
BG553_RS04260	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
BG553_RS04265	COG0534	Mate efflux family protein
BG553_RS04270	COG1074	ATP-dependent DNA helicase activity
BG553_RS04285	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
BG553_RS04290	COG0385	Bile acid
BG553_RS04295	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BG553_RS04300	COG0561	phosphatase activity
BG553_RS04310	COG1595	DNA-templated transcription, initiation
BG553_RS04315	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
BG553_RS04320	COG3026	antisigma factor binding
BG553_RS04330	COG0318	PFAM AMP-dependent synthetase and ligase
BG553_RS04335	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
BG553_RS04340	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BG553_RS04345	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BG553_RS04350	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
BG553_RS04355	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
BG553_RS04355	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
BG553_RS04360	COG1160	GTP binding
BG553_RS04370	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BG553_RS04380	COG1757	Na H antiporter
BG553_RS04385	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
BG553_RS04390	COG4172	Belongs to the ABC transporter superfamily
BG553_RS04395	COG0444	Belongs to the ABC transporter superfamily
BG553_RS04405	COG4166	transmembrane transport
BG553_RS04410	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BG553_RS04420	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BG553_RS04425	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
BG553_RS04430	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BG553_RS04430	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BG553_RS04435	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
BG553_RS04445	COG2801	Transposase and inactivated derivatives
BG553_RS04465	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
BG553_RS04475	COG2840	Smr protein MutS2
BG553_RS04480	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BG553_RS04490	COG0697	spore germination
BG553_RS04505	COG2198	Histidine kinase
BG553_RS04505	COG5002	protein histidine kinase activity
BG553_RS04505	COG0784	Response regulator, receiver
BG553_RS04510	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BG553_RS04520	COG1959	2 iron, 2 sulfur cluster binding
BG553_RS04530	COG0822	iron-sulfur transferase activity
BG553_RS04540	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
BG553_RS04550	COG2852	Protein conserved in bacteria
BG553_RS04565	COG0633	Ferredoxin
BG553_RS04570	COG2975	iron-sulfur cluster assembly
BG553_RS04575	COG1275	C4-dicarboxylate transporter malic acid transport protein
BG553_RS04580	COG0617	tRNA 3'-terminal CCA addition
BG553_RS04585	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BG553_RS04590	COG0730	response to heat
BG553_RS04595	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
BG553_RS04600	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
BG553_RS04610	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
BG553_RS04620	COG4969	Belongs to the N-Me-Phe pilin family
BG553_RS04625	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BG553_RS04630	COG1459	type II secretion system
BG553_RS04640	COG0237	dephospho-CoA kinase activity
BG553_RS04640	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
BG553_RS04645	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
BG553_RS04650	COG1466	dna polymerase III delta subunit
BG553_RS04655	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
BG553_RS04660	COG0495	leucyl-tRNA aminoacylation
BG553_RS04680	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
BG553_RS04695	COG3106	COG3106 Predicted ATPase
BG553_RS04700	COG3025	triphosphatase activity
BG553_RS04710	COG3140	Belongs to the UPF0181 family
BG553_RS04715	COG0564	pseudouridine synthase activity
BG553_RS04720	COG3098	single-species biofilm formation
BG553_RS04725	COG0135	phosphoribosylanthranilate isomerase activity
BG553_RS04725	COG0134	indole-3-glycerol-phosphate synthase activity
BG553_RS04730	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
BG553_RS04730	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BG553_RS04735	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BG553_RS04740	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BG553_RS04745	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BG553_RS04760	COG0750	zinc metalloprotease
BG553_RS04765	COG0575	Belongs to the CDS family
BG553_RS04770	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BG553_RS04775	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BG553_RS04785	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
BG553_RS04795	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
BG553_RS04820	COG1704	LemA family
BG553_RS04835	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BG553_RS04835	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BG553_RS04835	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
BG553_RS04840	COG1105	Belongs to the carbohydrate kinase PfkB family
BG553_RS04845	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BG553_RS04845	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
BG553_RS04850	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
BG553_RS04855	COG1523	belongs to the glycosyl hydrolase 13 family
BG553_RS04870	COG0058	SHG alpha-glucan phosphorylase activity
BG553_RS04875	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
BG553_RS04880	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
BG553_RS04885	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
BG553_RS04890	COG0583	DNA-binding transcription factor activity
BG553_RS04895	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BG553_RS04960	COG0582	viral genome integration into host DNA
BG553_RS04965	COG0582	viral genome integration into host DNA
BG553_RS04975	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BG553_RS04980	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BG553_RS04985	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
BG553_RS04995	COG3264	Mechanosensitive ion channel
BG553_RS04995	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
BG553_RS05000	COG0318	PFAM AMP-dependent synthetase and ligase
BG553_RS05010	COG0596	Alpha beta hydrolase
BG553_RS05015	COG2226	methyltransferase
BG553_RS05025	COG0586	Pfam SNARE associated Golgi protein
BG553_RS05035	COG0717	Belongs to the dCTP deaminase family
BG553_RS05040	COG0572	uridine kinase
BG553_RS05050	COG1077	Cell shape determining protein MreB Mrl
BG553_RS05055	COG1792	Involved in formation and maintenance of cell shape
BG553_RS05060	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
BG553_RS05065	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BG553_RS05070	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BG553_RS05075	COG3676	manually curated
BG553_RS05080	COG0121	glutamine amidotransferase
BG553_RS05085	COG0142	geranyltranstransferase activity
BG553_RS05090	COG1722	exodeoxyribonuclease VII activity
BG553_RS05095	COG0633	Ferredoxin
BG553_RS05095	COG3217	Mosc domain protein beta barrel domain protein
BG553_RS05100	COG1368	sulfuric ester hydrolase activity
BG553_RS05115	COG0671	phosphoesterase, PA-phosphatase related
BG553_RS05120	COG1534	Rna-binding protein
BG553_RS05125	COG0463	Glycosyl transferase, family 2
BG553_RS05130	COG0859	PFAM glycosyl transferase family 9
BG553_RS05140	COG0328	RNA-DNA hybrid ribonuclease activity
BG553_RS05145	COG1286	toxin biosynthetic process
BG553_RS05160	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
BG553_RS05185	COG0305	Participates in initiation and elongation during chromosome replication
BG553_RS05205	COG2801	Transposase and inactivated derivatives
BG553_RS05215	COG3691	Protein conserved in bacteria
BG553_RS05220	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BG553_RS05225	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BG553_RS05230	COG3084	Protein conserved in bacteria
BG553_RS05235	COG1763	Mo-molybdopterin cofactor biosynthetic process
BG553_RS05245	COG0676	glucose-6-phosphate 1-epimerase activity
BG553_RS05255	COG2801	Transposase and inactivated derivatives
BG553_RS05270	COG0629	single-stranded DNA binding
BG553_RS05275	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BG553_RS05280	COG0659	secondary active sulfate transmembrane transporter activity
BG553_RS05290	COG1122	ATPase activity
BG553_RS05300	COG1199	ATP-dependent helicase activity
BG553_RS05310	COG1346	cytolysis
BG553_RS05315	COG1132	(ABC) transporter
BG553_RS05330	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BG553_RS05335	COG0167	dihydroorotate dehydrogenase activity
BG553_RS05340	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
BG553_RS05345	COG0508	dehydrogenase complex catalyzes the overall conversion of
BG553_RS05350	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BG553_RS05375	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BG553_RS05380	COG3676	manually curated
BG553_RS05385	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
BG553_RS05390	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BG553_RS05410	COG4991	sh3 domain protein
BG553_RS05415	COG0306	phosphate transporter
BG553_RS05420	COG1392	Phosphate transport regulator
BG553_RS05425	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
BG553_RS05440	COG4604	ABC transporter, ATP-binding protein
BG553_RS05445	COG4605	iron ion homeostasis
BG553_RS05450	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BG553_RS05455	COG4607	ABC-type enterochelin transport system periplasmic component
BG553_RS05460	COG0305	Participates in initiation and elongation during chromosome replication
BG553_RS05465	COG3100	YcgL domain-containing protein
BG553_RS05470	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
BG553_RS05485	COG3676	manually curated
BG553_RS05505	COG0425	Belongs to the sulfur carrier protein TusA family
BG553_RS05510	COG2391	methyltransferase activity
BG553_RS05520	COG1172	Belongs to the binding-protein-dependent transport system permease family
BG553_RS05525	COG1172	Belongs to the binding-protein-dependent transport system permease family
BG553_RS05545	COG0697	spore germination
BG553_RS05550	COG1278	Cold shock
BG553_RS05595	COG3787	Belongs to the UPF0306 family
BG553_RS05605	COG1811	Na channel or pump
BG553_RS05615	COG3028	Belongs to the UPF0307 family
BG553_RS05620	COG0312	modulator of DNA gyrase
BG553_RS05625	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
BG553_RS05630	COG4409	exo-alpha-(2->6)-sialidase activity
BG553_RS05655	COG1496	oxidoreductase activity
BG553_RS05660	COG0251	oxidation-reduction process
BG553_RS05670	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BG553_RS05675	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BG553_RS05685	COG2211	Major facilitator Superfamily
BG553_RS05690	COG1085	galactose-1-phosphate uridylyltransferase
BG553_RS05695	COG2271	Major facilitator Superfamily
BG553_RS05705	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BG553_RS05725	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BG553_RS05735	COG1509	lysine 2,3-aminomutase activity
BG553_RS05740	COG0017	Asparaginyl-tRNA synthetase
BG553_RS05745	COG2925	Exonuclease
BG553_RS05755	COG0613	PHP domain protein
BG553_RS05770	COG2837	iron assimilation
BG553_RS05785	COG0556	nucleotide-excision repair
BG553_RS05795	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
BG553_RS05805	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
BG553_RS05810	COG0625	glutathione transferase activity
BG553_RS05815	COG2969	positive regulation of protein catabolic process
BG553_RS05830	COG0583	DNA-binding transcription factor activity
BG553_RS05835	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BG553_RS05850	COG2226	methyltransferase
BG553_RS05855	COG3036	rescue of stalled ribosome
BG553_RS05860	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
BG553_RS05865	COG1940	carbohydrate kinase activity
BG553_RS05865	COG1846	Transcriptional regulator
BG553_RS05870	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
BG553_RS05875	COG1522	sequence-specific DNA binding
BG553_RS05880	COG1674	ftsk spoiiie
BG553_RS05885	COG2321	neutral zinc metallopeptidase
BG553_RS05890	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
BG553_RS05895	COG1214	PFAM Peptidase M22, glycoprotease
BG553_RS05900	COG0730	response to heat
BG553_RS05905	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BG553_RS05910	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BG553_RS05915	COG3119	arylsulfatase activity
BG553_RS05920	COG0641	radical SAM
BG553_RS05925	COG1435	thymidine kinase activity
BG553_RS05930	COG3074	FtsZ-dependent cytokinesis
BG553_RS05935	COG1494	fructose-1,6-bisphosphatase
BG553_RS05945	COG0006	proline dipeptidase activity
BG553_RS05955	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BG553_RS05955	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
BG553_RS05960	COG0697	spore germination
BG553_RS05965	COG0440	acetolactate synthase activity
BG553_RS05970	COG0028	Belongs to the TPP enzyme family
BG553_RS05975	COG0288	reversible hydration of carbon dioxide
BG553_RS05980	COG0857	belongs to the CobB CobQ family
BG553_RS05980	COG0280	phosphate acetyltransferase
BG553_RS05990	COG0737	Belongs to the 5'-nucleotidase family
BG553_RS06000	COG0626	cystathionine gamma-synthase activity
BG553_RS06025	COG2363	Small membrane protein
BG553_RS06030	COG0659	secondary active sulfate transmembrane transporter activity
BG553_RS06035	COG0243	molybdopterin cofactor binding
BG553_RS06040	COG1049	propionate catabolic process, 2-methylcitrate cycle
BG553_RS06045	COG0538	isocitrate dehydrogenase activity
BG553_RS06065	COG2801	Transposase and inactivated derivatives
BG553_RS06080	COG0243	molybdopterin cofactor binding
BG553_RS06090	COG2909	trisaccharide binding
BG553_RS06100	COG0315	cyclic pyranopterin monophosphate synthase activity
BG553_RS06105	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
BG553_RS06110	COG0314	molybdopterin synthase activity
BG553_RS06115	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
BG553_RS06120	COG1444	tRNA N-acetyltransferase activity
BG553_RS06125	COG1448	Aminotransferase
BG553_RS06130	COG0285	dihydrofolate synthase activity
BG553_RS06140	COG3956	TIGRFAM MazG family protein
BG553_RS06165	COG1136	(ABC) transporter
BG553_RS06165	COG0577	efflux transmembrane transporter activity
BG553_RS06170	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
BG553_RS06175	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BG553_RS06180	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BG553_RS06240	COG3210	domain, Protein
BG553_RS06245	COG2831	hemolysin activation secretion protein
BG553_RS06255	COG1943	Transposase
BG553_RS06260	COG0658	competence protein
BG553_RS06260	COG2333	competence protein COMEC
BG553_RS06265	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
BG553_RS06270	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
BG553_RS06275	COG0737	Belongs to the 5'-nucleotidase family
BG553_RS06280	COG2801	Transposase and inactivated derivatives
BG553_RS06290	COG1737	Transcriptional regulator
BG553_RS06295	COG2731	YhcH YjgK YiaL family protein
BG553_RS06300	COG0248	Ppx GppA phosphatase
BG553_RS06305	COG2926	Belongs to the UPF0265 family
BG553_RS06310	COG1263	PTS System
BG553_RS06310	COG2190	(PTS) system
BG553_RS06310	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BG553_RS06315	COG0527	aspartate kinase activity
BG553_RS06320	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BG553_RS06345	COG0745	RESPONSE REGULATOR receiver
BG553_RS06350	COG5002	protein histidine kinase activity
BG553_RS06360	COG4785	May be involved in cell division
BG553_RS06365	COG0513	Belongs to the DEAD box helicase family
BG553_RS06370	COG0590	tRNA wobble adenosine to inosine editing
BG553_RS06375	COG2951	lytic endotransglycosylase activity
BG553_RS06380	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
BG553_RS06385	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
BG553_RS06390	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
BG553_RS06395	COG0195	Participates in both transcription termination and antitermination
BG553_RS06400	COG0779	Required for maturation of 30S ribosomal subunits
BG553_RS06410	COG0741	lytic transglycosylase activity
BG553_RS06415	COG0023	Translation Initiation Factor
BG553_RS06420	COG0284	orotidine-5'-phosphate decarboxylase activity
BG553_RS06425	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
BG553_RS06430	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
BG553_RS06440	COG0539	negative regulation of cytoplasmic translation
BG553_RS06445	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
BG553_RS06450	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BG553_RS06455	COG0791	NLP P60 protein
BG553_RS06465	COG0072	phenylalanine-tRNA ligase activity
BG553_RS06475	COG0778	Nitroreductase
BG553_RS06485	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
BG553_RS06500	COG3022	response to hydroperoxide
BG553_RS06510	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
BG553_RS06515	COG3105	Protein conserved in bacteria
BG553_RS06530	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BG553_RS06540	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BG553_RS06545	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BG553_RS06550	COG1309	transcriptional regulator
BG553_RS06560	COG3083	sulfuric ester hydrolase activity
BG553_RS06570	COG2814	Major facilitator Superfamily
BG553_RS06580	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
BG553_RS06590	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BG553_RS06595	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
BG553_RS06605	COG0589	response to stress
BG553_RS06615	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
BG553_RS06635	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
BG553_RS06675	COG0629	single-stranded DNA binding
BG553_RS06730	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BG553_RS06745	COG2801	Transposase and inactivated derivatives
BG553_RS06800	COG5301	cellulose 1,4-beta-cellobiosidase activity
BG553_RS06855	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
BG553_RS06905	COG4695	Portal protein
BG553_RS06910	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BG553_RS06925	COG5645	(Lipo)protein
BG553_RS06930	COG4172	Belongs to the ABC transporter superfamily
BG553_RS06935	COG4171	peptide transport system, permease
BG553_RS06940	COG4168	peptide transport system, permease
BG553_RS06945	COG4166	transmembrane transport
BG553_RS06950	COG3283	Transcriptional regulator of aromatic amino acids metabolism
BG553_RS06955	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
BG553_RS06960	COG2983	Belongs to the UPF0260 family
BG553_RS06965	COG0393	Putative heavy-metal-binding
BG553_RS06970	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
BG553_RS06980	COG3850	Histidine kinase
BG553_RS06985	COG0561	phosphatase activity
BG553_RS06995	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
BG553_RS07000	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BG553_RS07005	COG0739	heme binding
BG553_RS07010	COG1121	(ABC) transporter
BG553_RS07015	COG0567	Dehydrogenase, E1 component
BG553_RS07020	COG0508	dehydrogenase complex catalyzes the overall conversion of
BG553_RS07025	COG0045	succinate-CoA ligase (ADP-forming) activity
BG553_RS07030	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
BG553_RS07035	COG1115	amino acid carrier protein
BG553_RS07040	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
BG553_RS07045	COG3683	transport system, periplasmic component
BG553_RS07065	COG5301	cellulose 1,4-beta-cellobiosidase activity
BG553_RS07210	COG5410	chromosome segregation
BG553_RS07235	COG3179	chitinase
BG553_RS07335	COG3617	BRO family, N-terminal domain
BG553_RS07360	COG3723	Recombinational DNA repair protein, rece pathway
BG553_RS07420	COG0281	malic enzyme
BG553_RS07420	COG0280	phosphate acetyltransferase
BG553_RS07425	COG0189	ligase activity
BG553_RS07435	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BG553_RS07445	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
BG553_RS07450	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BG553_RS07450	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BG553_RS07455	COG5339	Protein conserved in bacteria
BG553_RS07460	COG0159	tryptophan synthase activity
BG553_RS07470	COG4221	oxidoreductase activity
BG553_RS07475	COG1757	Na H antiporter
BG553_RS07480	COG2916	Histone family protein nucleoid-structuring protein H-NS
BG553_RS07485	COG0788	formyltetrahydrofolate deformylase activity
BG553_RS07490	COG2949	membrane
BG553_RS07495	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BG553_RS07500	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BG553_RS07505	COG1530	ribonuclease E activity
BG553_RS07515	COG1518	maintenance of DNA repeat elements
BG553_RS07560	COG1944	ATP diphosphatase activity
BG553_RS07565	COG0500	methyltransferase
BG553_RS07570	COG0187	DNA topoisomerase II activity
BG553_RS07585	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
BG553_RS07590	COG1349	DNA-binding transcription factor activity
BG553_RS07595	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BG553_RS07600	COG2915	High frequency lysogenization protein hflD homolog
BG553_RS07605	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
BG553_RS07610	COG4988	ABC transporter
BG553_RS07615	COG2911	Protein conserved in bacteria
BG553_RS07620	COG0729	surface antigen
BG553_RS07630	COG4942	peptidase
BG553_RS07640	COG0233	cytoplasmic translational termination
BG553_RS07645	COG0528	UMP kinase activity
BG553_RS07650	COG2194	sulfuric ester hydrolase activity
BG553_RS07665	COG1840	ABC-type Fe3 transport system, periplasmic component
BG553_RS07675	COG3842	ATPase activity
BG553_RS07680	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
BG553_RS07685	COG0433	COG0433 Predicted ATPase
BG553_RS07690	COG0513	Belongs to the DEAD box helicase family
BG553_RS07705	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
BG553_RS07715	COG0681	Belongs to the peptidase S26 family
BG553_RS07725	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
BG553_RS07740	COG2259	Doxx family
BG553_RS07755	COG3219	Protein conserved in bacteria
BG553_RS07760	COG1595	DNA-templated transcription, initiation
BG553_RS07775	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BG553_RS07790	COG1620	l-lactate permease
BG553_RS07795	COG0549	Belongs to the carbamate kinase family
BG553_RS07800	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
BG553_RS07805	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
BG553_RS07810	COG3257	ureidoglycine aminohydrolase activity
BG553_RS07820	COG1953	Uracil, thiamine, allantoin
BG553_RS07840	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
BG553_RS07845	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
BG553_RS07850	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BG553_RS07870	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
BG553_RS07875	COG0732	type I restriction modification DNA specificity domain
BG553_RS07885	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
BG553_RS07895	COG2350	Protein conserved in bacteria
BG553_RS07900	COG1607	acyl-coa hydrolase
BG553_RS07905	COG2917	probably involved in intracellular septation
BG553_RS07915	COG3092	negative regulation of chromosome organization
BG553_RS07925	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BG553_RS07930	COG0303	'Molybdopterin
BG553_RS07935	COG2095	MarC family integral membrane protein
BG553_RS07945	COG0488	(ABC) transporter
BG553_RS07960	COG0564	pseudouridine synthase activity
BG553_RS07975	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BG553_RS07985	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
BG553_RS08000	COG0823	Involved in the tonB-independent uptake of proteins
BG553_RS08005	COG3064	Membrane
BG553_RS08010	COG0848	biopolymer transport protein
BG553_RS08015	COG0811	peptide transport
BG553_RS08020	COG0824	Thioesterase
BG553_RS08035	COG1294	oxidase, subunit
BG553_RS08040	COG1271	oxidase subunit
BG553_RS08065	COG2801	Transposase and inactivated derivatives
BG553_RS08075	COG0494	nUDIX hydrolase
BG553_RS08105	COG0271	Belongs to the BolA IbaG family
BG553_RS08120	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BG553_RS08125	COG1678	Uncharacterized ACR, COG1678
BG553_RS08135	COG0628	permease
BG553_RS08140	COG1115	amino acid carrier protein
BG553_RS08145	COG1525	nuclease
BG553_RS08205	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BG553_RS08210	COG0205	6-phosphofructokinase activity
BG553_RS08220	COG0301	tRNA thio-modification
BG553_RS08220	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BG553_RS08245	COG0330	HflC and HflK could
BG553_RS08250	COG0330	HflC and HflK could
BG553_RS08255	COG3676	manually curated
BG553_RS08270	COG0542	response to heat
BG553_RS08280	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
BG553_RS08290	COG0295	cytidine deaminase activity
BG553_RS08300	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
BG553_RS08310	COG0187	DNA topoisomerase II activity
BG553_RS08325	COG2801	Transposase and inactivated derivatives
BG553_RS08340	COG2801	Transposase and inactivated derivatives
BG553_RS08350	COG0789	Transcriptional regulator
BG553_RS08355	COG2217	Heavy metal translocating P-type atpase
BG553_RS08360	COG2217	Heavy metal translocating P-type atpase
BG553_RS08370	COG0302	gtp cyclohydrolase
BG553_RS08375	COG3642	lipopolysaccharide core region biosynthetic process
BG553_RS08380	COG0489	protein tyrosine kinase activity
BG553_RS08385	COG4166	transmembrane transport
BG553_RS08390	COG2095	MarC family integral membrane protein
BG553_RS08395	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BG553_RS08400	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BG553_RS08405	COG2354	Protein conserved in bacteria
BG553_RS08410	COG3071	HemY protein
BG553_RS08415	COG2959	enzyme of heme biosynthesis
BG553_RS08425	COG0181	hydroxymethylbilane synthase activity
BG553_RS08430	COG1012	belongs to the aldehyde dehydrogenase family
BG553_RS08430	COG1454	alcohol dehydrogenase
BG553_RS08440	COG0531	amino acid
BG553_RS08450	COG2801	Transposase and inactivated derivatives
BG553_RS08460	COG0860	N-Acetylmuramoyl-L-alanine amidase
BG553_RS08460	COG1388	LysM domain
BG553_RS08465	COG0802	atpase or kinase
BG553_RS08470	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
BG553_RS08480	COG1519	Transferase
BG553_RS08485	COG0826	peptidase U32
BG553_RS08500	COG0795	lipopolysaccharide-transporting ATPase activity
BG553_RS08505	COG0795	lipopolysaccharide-transporting ATPase activity
BG553_RS08515	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BG553_RS08520	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BG553_RS08525	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
BG553_RS08540	COG3711	transcriptional antiterminator
BG553_RS08540	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BG553_RS08555	COG3716	PTS system mannose fructose sorbose family IID component
BG553_RS08560	COG3715	PTS system
BG553_RS08565	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BG553_RS08570	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BG553_RS08570	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
BG553_RS08575	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BG553_RS08585	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
BG553_RS08595	COG1902	pentaerythritol trinitrate reductase activity
BG553_RS08605	COG1764	response to oxidative stress
BG553_RS08610	COG2207	Transcriptional regulator
BG553_RS08615	COG0813	purine-nucleoside phosphorylase activity
BG553_RS08625	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BG553_RS08635	COG1216	Glycosyl transferase, family 2
BG553_RS08640	COG1216	Glycosyl transferase, family 2
BG553_RS08650	COG3306	glycosyltransferase involved in LPS biosynthesis
BG553_RS08660	COG2244	polysaccharide biosynthetic process
BG553_RS08675	COG2089	acid synthase
BG553_RS08685	COG1434	Gram-negative-bacterium-type cell wall biogenesis
BG553_RS08690	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BG553_RS08700	COG1280	lysine exporter protein (LysE YggA)
BG553_RS08710	COG0436	Aminotransferase
BG553_RS08715	COG1169	isochorismate synthase
BG553_RS08730	COG0602	queuosine metabolic process
BG553_RS08735	COG0720	synthase
BG553_RS08745	COG2960	long-chain fatty acid transporting porin activity
BG553_RS08750	COG0166	Belongs to the GPI family
BG553_RS08775	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BG553_RS08780	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BG553_RS08790	COG0460	homoserine dehydrogenase
BG553_RS08790	COG0527	aspartate kinase activity
BG553_RS08795	COG0083	homoserine kinase activity
BG553_RS08800	COG0215	cysteine-tRNA ligase activity
BG553_RS08805	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BG553_RS08825	COG0437	4 iron, 4 sulfur cluster binding
BG553_RS08830	COG2864	formate dehydrogenase
BG553_RS08835	COG3058	Necessary for formate dehydrogenase activity
BG553_RS08845	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BG553_RS08855	COG0778	Nitroreductase
BG553_RS08860	COG4172	Belongs to the ABC transporter superfamily
BG553_RS08865	COG0191	fructose-bisphosphate aldolase activity
BG553_RS08870	COG0126	phosphoglycerate kinase activity
BG553_RS08875	COG0733	neurotransmitter:sodium symporter activity
BG553_RS08880	COG0338	D12 class N6 adenine-specific DNA methyltransferase
BG553_RS08885	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
BG553_RS08890	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BG553_RS08900	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
BG553_RS08925	COG4796	Type ii and iii secretion system protein
BG553_RS08930	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BG553_RS08935	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
BG553_RS08940	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
BG553_RS08945	COG1280	lysine exporter protein (LysE YggA)
BG553_RS08950	COG0632	four-way junction helicase activity
BG553_RS08955	COG2255	four-way junction helicase activity
BG553_RS08960	COG4160	amino acid transport
BG553_RS08965	COG4215	(ABC) transporter
BG553_RS08970	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BG553_RS08975	COG1126	abc transporter atp-binding protein
BG553_RS08980	COG4232	protein-disulfide reductase activity
BG553_RS08985	COG3101	peptidyl-lysine hydroxylation
BG553_RS08990	COG1022	Amp-dependent synthetase and ligase
BG553_RS08995	COG0251	oxidation-reduction process
BG553_RS09005	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BG553_RS09010	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
BG553_RS09015	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
BG553_RS09020	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
BG553_RS09030	COG1605	Chorismate mutase
BG553_RS09030	COG0287	Prephenate dehydrogenase
BG553_RS09035	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
BG553_RS09040	COG0859	PFAM glycosyl transferase family 9
BG553_RS09045	COG0469	pyruvate kinase activity
BG553_RS09050	COG2062	phosphohistidine phosphatase, SixA
BG553_RS09055	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BG553_RS09065	COG4771	TonB-dependent receptor
BG553_RS09065	COG1629	transport
BG553_RS09075	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BG553_RS09080	COG0346	lactoylglutathione lyase activity
BG553_RS09095	COG2911	Protein conserved in bacteria
BG553_RS09105	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BG553_RS09110	COG0617	tRNA 3'-terminal CCA addition
BG553_RS09115	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
BG553_RS09120	COG4143	(ABC) transporter
BG553_RS09125	COG0402	S-adenosylhomocysteine deaminase activity
BG553_RS09130	COG3753	Protein conserved in bacteria
BG553_RS09140	COG0492	ferredoxin-NADP+ reductase activity
BG553_RS09145	COG2376	Dihydroxyacetone kinase
BG553_RS09150	COG1461	Dihydroxyacetone kinase
BG553_RS09155	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
BG553_RS09155	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BG553_RS09155	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BG553_RS09160	COG3118	belongs to the thioredoxin family
BG553_RS09190	COG3115	cell septum assembly
BG553_RS09210	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BG553_RS09220	COG0475	glutathione-regulated potassium exporter activity
BG553_RS09220	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BG553_RS09230	COG4580	involved in the transport of maltose and maltodextrins
BG553_RS09235	COG3842	ATPase activity
BG553_RS09245	COG1175	transmembrane transport
BG553_RS09250	COG3833	ABC-type maltose transport systems, permease component
BG553_RS09255	COG0366	Alpha amylase catalytic
BG553_RS09260	COG2909	trisaccharide binding
BG553_RS09265	COG0058	SHG alpha-glucan phosphorylase activity
BG553_RS09270	COG1640	4-alpha-glucanotransferase
BG553_RS09280	COG2056	Na+-H+ antiporter family
BG553_RS09285	COG0708	Exodeoxyribonuclease III
BG553_RS09290	COG3117	lipopolysaccharide transmembrane transporter activity
BG553_RS09295	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
BG553_RS09300	COG1137	ATPase activity
BG553_RS09305	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BG553_RS09315	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BG553_RS09330	COG2177	Part of the ABC transporter FtsEX involved in
BG553_RS09335	COG2884	Cell division ATP-binding protein ftsE
BG553_RS09340	COG0552	protein localization to endoplasmic reticulum
BG553_RS09345	COG0742	ribosomal rna small subunit methyltransferase
BG553_RS09350	COG3099	Belongs to the UPF0263 family
BG553_RS09355	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BG553_RS09365	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
BG553_RS09370	COG3326	Membrane
BG553_RS09375	COG1027	Aspartate ammonia-lyase
BG553_RS09380	COG0210	DNA helicase
BG553_RS09385	COG3842	ATPase activity
BG553_RS09390	COG1176	ABC-type spermidine putrescine transport system, permease component I
BG553_RS09395	COG1177	transmembrane transport
BG553_RS09400	COG0601	transmembrane transport
BG553_RS09405	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BG553_RS09410	COG4172	Belongs to the ABC transporter superfamily
BG553_RS09430	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BG553_RS09435	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
BG553_RS09440	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
BG553_RS09460	COG2801	Transposase and inactivated derivatives
BG553_RS09480	COG2801	Transposase and inactivated derivatives
BG553_RS09560	COG0740	serine-type endopeptidase activity
BG553_RS09600	COG3179	chitinase
BG553_RS09640	COG1403	HNH endonuclease
BG553_RS09685	COG1724	mRNA binding
BG553_RS09690	COG1598	PFAM Uncharacterised protein family UPF0150
BG553_RS09720	COG0629	single-stranded DNA binding
BG553_RS09755	COG3392	D12 class N6 adenine-specific DNA methyltransferase
BG553_RS09775	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BG553_RS09795	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BG553_RS09800	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BG553_RS09805	COG0483	inositol monophosphate 1-phosphatase activity
BG553_RS09810	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BG553_RS09815	COG1966	Carbon starvation protein
BG553_RS09820	COG0084	hydrolase, TatD family'
BG553_RS09845	COG4591	ABC-type transport system involved in lipoprotein release permease component
BG553_RS09850	COG1136	(ABC) transporter
BG553_RS09855	COG4591	ABC-type transport system involved in lipoprotein release permease component
BG553_RS09860	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BG553_RS09885	COG0512	Glutamine amidotransferase of anthranilate synthase
BG553_RS09890	COG1322	Protein conserved in bacteria
BG553_RS09890	COG1322	Protein conserved in bacteria
BG553_RS09900	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BG553_RS09910	COG2137	regulation of response to DNA damage stimulus
BG553_RS09920	COG0551	DNA topoisomerase type I activity
BG553_RS09925	COG0009	L-threonylcarbamoyladenylate synthase
BG553_RS09930	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BG553_RS09955	COG0210	DNA helicase
BG553_RS09960	COG1090	epimerase
BG553_RS09980	COG1666	GTP binding
BG553_RS09985	COG0560	Phosphoserine phosphatase
BG553_RS09995	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
BG553_RS10000	COG2081	HI0933 family
BG553_RS10005	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
BG553_RS10010	COG2252	PERMEase
BG553_RS10015	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BG553_RS10025	COG0716	FMN binding
BG553_RS10030	COG0735	belongs to the Fur family
BG553_RS10035	COG3008	intermembrane lipid transfer
BG553_RS10040	COG1854	S-ribosylhomocysteine lyase activity
BG553_RS10045	COG1132	(ABC) transporter
BG553_RS10050	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BG553_RS10055	COG0592	DNA-directed DNA polymerase activity
BG553_RS10060	COG2976	Protein conserved in bacteria
BG553_RS10070	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
BG553_RS10075	COG1426	Protein conserved in bacteria
BG553_RS10080	COG0165	Argininosuccinate lyase
BG553_RS10100	COG2801	Transposase and inactivated derivatives
BG553_RS10110	COG2801	Transposase and inactivated derivatives
BG553_RS10120	COG0783	Belongs to the Dps family
BG553_RS10125	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BG553_RS10130	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
BG553_RS10145	COG3676	manually curated
BG553_RS10155	COG2801	Transposase and inactivated derivatives
BG553_RS10165	COG2991	Protein conserved in bacteria
BG553_RS10170	COG1477	protein flavinylation
BG553_RS10175	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
BG553_RS10180	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
BG553_RS10185	COG2871	sodium ion transport
BG553_RS10190	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
BG553_RS10195	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
BG553_RS10200	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
BG553_RS10205	COG1805	sodium ion transport
BG553_RS10215	COG0316	Belongs to the HesB IscA family
BG553_RS10215	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
BG553_RS10225	COG0252	asparaginase activity
BG553_RS10235	COG0583	DNA-binding transcription factor activity
BG553_RS10240	COG1011	Hydrolase
BG553_RS10245	COG0583	DNA-binding transcription factor activity
BG553_RS10250	COG1162	GTPase activity
BG553_RS10260	COG0537	adenosine 5'-monophosphoramidase activity
BG553_RS10270	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BG553_RS10275	COG3108	Peptidase M15
BG553_RS10280	COG2989	Protein conserved in bacteria
BG553_RS10285	COG0793	Belongs to the peptidase S41A family
BG553_RS10290	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
BG553_RS10300	COG2814	Major facilitator Superfamily
BG553_RS10305	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BG553_RS10315	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BG553_RS10345	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
BG553_RS10350	COG0792	nuclease activity
BG553_RS10355	COG3107	peptidoglycan biosynthetic process
BG553_RS10375	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BG553_RS10380	COG1414	Transcriptional regulator
BG553_RS10385	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BG553_RS10395	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
BG553_RS10410	COG3068	Protein conserved in bacteria
BG553_RS10420	COG2801	Transposase and inactivated derivatives
BG553_RS10435	COG1530	ribonuclease E activity
BG553_RS10445	COG4977	sequence-specific DNA binding
BG553_RS10445	COG1917	Cupin 2, conserved barrel domain protein
BG553_RS10455	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
BG553_RS10460	COG2824	Alkylphosphonate utilization operon protein PhnA
BG553_RS10465	COG0557	exoribonuclease II activity
BG553_RS10485	COG3116	cell division
BG553_RS10490	COG0768	penicillin binding
BG553_RS10495	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BG553_RS10505	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BG553_RS10510	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BG553_RS10515	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BG553_RS10520	COG0772	Belongs to the SEDS family
BG553_RS10525	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BG553_RS10535	COG1181	Belongs to the D-alanine--D-alanine ligase family
BG553_RS10545	COG0849	cell division
BG553_RS10560	COG0497	DNA recombination
BG553_RS10595	COG2801	Transposase and inactivated derivatives
BG553_RS10605	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
BG553_RS10615	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
BG553_RS10620	COG2259	Doxx family
BG553_RS10625	COG1040	competence protein
BG553_RS10630	COG0561	phosphatase activity
BG553_RS10635	COG0697	spore germination
BG553_RS10640	COG0697	spore germination
BG553_RS10650	COG0261	This protein binds to 23S rRNA in the presence of protein L20
BG553_RS10655	COG0142	geranyltranstransferase activity
BG553_RS10660	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BG553_RS10665	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
BG553_RS10675	COG1028	Short-chain dehydrogenase reductase Sdr
BG553_RS10680	COG1114	Component of the transport system for branched-chain amino acids
BG553_RS10690	COG1490	D-aminoacyl-tRNA deacylase activity
BG553_RS10695	COG1295	ribonuclease BN
BG553_RS10710	COG3041	Addiction module toxin RelE StbE family
BG553_RS10715	COG3077	Addiction module antitoxin, RelB DinJ family
BG553_RS10730	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BG553_RS10740	COG2801	Transposase and inactivated derivatives
BG553_RS10745	COG2818	Glycosylase
BG553_RS10755	COG4942	peptidase
BG553_RS10755	COG1388	LysM domain
BG553_RS10770	COG1238	metal cluster binding
BG553_RS10775	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
BG553_RS10795	COG3716	PTS system mannose fructose sorbose family IID component
BG553_RS10800	COG3715	PTS system
BG553_RS10805	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BG553_RS10805	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
BG553_RS10820	COG4974	Belongs to the 'phage' integrase family
BG553_RS10845	COG0688	phosphatidylethanolamine metabolic process
BG553_RS10850	COG1555	photosystem II stabilization
BG553_RS10855	COG3061	Opacity-associated protein A
BG553_RS10855	COG3266	domain, Protein
BG553_RS10865	COG0859	PFAM glycosyl transferase family 9
BG553_RS10870	COG0859	PFAM glycosyl transferase family 9
BG553_RS10875	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BG553_RS10880	COG0049	tRNA binding
BG553_RS10885	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BG553_RS10895	COG0544	peptidyl-prolyl cis-trans isomerase activity
BG553_RS10900	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BG553_RS10905	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
BG553_RS10910	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
BG553_RS10915	COG1045	serine acetyltransferase
BG553_RS10940	COG0582	viral genome integration into host DNA
BG553_RS10950	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BG553_RS10970	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
BG553_RS10980	COG1217	gtp-binding protein TYPA
BG553_RS10985	COG0456	acetyltransferase
BG553_RS10990	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
BG553_RS11015	COG0131	Imidazoleglycerol-phosphate dehydratase
BG553_RS11015	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
BG553_RS11030	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
BG553_RS11045	COG0107	imidazoleglycerol-phosphate synthase activity
BG553_RS11065	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
BG553_RS11070	COG0494	nUDIX hydrolase
BG553_RS11075	COG1218	3'(2'),5'-bisphosphate nucleotidase
BG553_RS11080	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BG553_RS11085	COG0363	glucosamine-6-phosphate deaminase activity
BG553_RS11095	COG1794	racemase activity, acting on amino acids and derivatives
BG553_RS11100	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
BG553_RS11110	COG0525	valine-tRNA ligase activity
BG553_RS11120	COG4185	zeta toxin
BG553_RS11125	COG3177	Filamentation induced by cAMP protein fic
BG553_RS11130	COG2153	protein acetylation
BG553_RS11135	COG2927	DNA polymerase III (CHI subunit)
BG553_RS11140	COG1652	LysM domain
BG553_RS11175	COG2801	Transposase and inactivated derivatives
BG553_RS11220	COG0598	Magnesium transport protein CorA
BG553_RS11225	COG2226	methyltransferase
BG553_RS11230	COG3165	ubiquinone biosynthetic process from chorismate
BG553_RS11235	COG4804	nuclease activity
BG553_RS11240	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BG553_RS11245	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BG553_RS11250	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BG553_RS11255	COG0805	protein transport
BG553_RS11265	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BG553_RS11270	COG0220	tRNA (guanine-N7-)-methyltransferase activity
BG553_RS11275	COG3171	Protein conserved in bacteria
BG553_RS11285	COG0762	integral membrane protein
BG553_RS11290	COG1126	abc transporter atp-binding protein
BG553_RS11295	COG0765	amino acid transport
BG553_RS11300	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BG553_RS11305	COG0257	Belongs to the bacterial ribosomal protein bL36 family
BG553_RS11315	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BG553_RS11330	COG2801	Transposase and inactivated derivatives
BG553_RS11370	COG2801	Transposase and inactivated derivatives
BG553_RS11380	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BG553_RS11415	COG3617	BRO family, N-terminal domain
BG553_RS11465	COG3723	Recombinational DNA repair protein, rece pathway
BG553_RS11595	COG3179	chitinase
BG553_RS11615	COG3728	DNA packaging
BG553_RS11620	COG1783	phage Terminase large subunit
BG553_RS11680	COG1598	PFAM Uncharacterised protein family UPF0150
BG553_RS11685	COG1724	mRNA binding
BG553_RS11770	COG0604	alcohol dehydrogenase
BG553_RS11770	COG1028	Short-chain dehydrogenase reductase Sdr
BG553_RS11770	COG3321	synthase
BG553_RS11780	COG0778	Nitroreductase
BG553_RS11785	COG1902	pentaerythritol trinitrate reductase activity
BG553_RS11795	COG0431	NADPH-dependent FMN reductase
BG553_RS11805	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
BG553_RS11815	COG0564	pseudouridine synthase activity
BG553_RS11820	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
BG553_RS11825	COG1393	Belongs to the ArsC family
BG553_RS11830	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BG553_RS11840	COG2391	methyltransferase activity
BG553_RS11845	COG2391	methyltransferase activity
BG553_RS11850	COG0425	Belongs to the sulfur carrier protein TusA family
BG553_RS11855	COG0753	catalase activity
BG553_RS11875	COG0347	Belongs to the P(II) protein family
BG553_RS11905	COG2801	Transposase and inactivated derivatives
BG553_RS11920	COG0494	nUDIX hydrolase
BG553_RS11925	COG0730	response to heat
BG553_RS11935	COG0546	phosphoglycolate phosphatase activity
BG553_RS11950	COG0180	Tryptophanyl-tRNA synthetase
BG553_RS11955	COG0501	Belongs to the peptidase M48B family
BG553_RS11960	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
BG553_RS11980	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BG553_RS11985	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
BG553_RS11990	COG0470	DNA polymerase III
BG553_RS12005	COG0084	hydrolase, TatD family'
BG553_RS12015	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BG553_RS12020	COG1215	transferase activity, transferring glycosyl groups
BG553_RS12050	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
BG553_RS12055	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
BG553_RS12060	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BG553_RS12065	COG1053	succinate dehydrogenase
BG553_RS12070	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
BG553_RS12075	COG2962	Rard protein
BG553_RS12080	COG2223	nitrite transmembrane transporter activity
BG553_RS12085	COG2223	nitrite transmembrane transporter activity
BG553_RS12090	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BG553_RS12095	COG2020	methyltransferase activity
BG553_RS12100	COG0728	peptidoglycan biosynthetic process
BG553_RS12105	COG0268	Binds directly to 16S ribosomal RNA
BG553_RS12110	COG1970	mechanosensitive ion channel activity
BG553_RS12115	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
BG553_RS12120	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BG553_RS12125	COG1739	Uncharacterized protein family UPF0029
BG553_RS12135	COG1119	ATPase activity
BG553_RS12145	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BG553_RS12150	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
BG553_RS12160	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BG553_RS12165	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
BG553_RS12170	COG0321	lipoyl(octanoyl) transferase activity
BG553_RS12175	COG2921	Belongs to the UPF0250 family
BG553_RS12180	COG1686	Belongs to the peptidase S11 family
BG553_RS12185	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
BG553_RS12190	COG0772	Belongs to the SEDS family
BG553_RS12195	COG0768	penicillin binding
BG553_RS12205	COG0799	negative regulation of ribosome biogenesis
BG553_RS12215	COG1312	Catalyzes the dehydration of D-mannonate
BG553_RS12220	COG2186	Transcriptional regulator
BG553_RS12225	COG1028	Short-chain dehydrogenase reductase Sdr
BG553_RS12240	COG2211	Major facilitator Superfamily
BG553_RS12255	COG0800	Aldolase
BG553_RS12260	COG4783	chaperone-mediated protein folding
BG553_RS12280	COG0545	Peptidyl-prolyl cis-trans isomerase
BG553_RS12285	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BG553_RS12300	COG0037	tRNA processing
BG553_RS12305	COG4974	Belongs to the 'phage' integrase family
BG553_RS12340	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BG553_RS12365	COG3133	Outer membrane lipoprotein
BG553_RS12370	COG3102	Protein conserved in bacteria
BG553_RS12375	COG0018	arginyl-trna synthetase
BG553_RS12380	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BG553_RS12390	COG1138	Cytochrome C-type biogenesis protein
BG553_RS12400	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BG553_RS12405	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BG553_RS12410	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BG553_RS12415	COG4133	protoheme IX ABC transporter activity
BG553_RS12420	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BG553_RS12425	COG0747	negative chemotaxis
BG553_RS12430	COG0601	transmembrane transport
BG553_RS12435	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BG553_RS12440	COG0444	Belongs to the ABC transporter superfamily
BG553_RS12445	COG4608	Belongs to the ABC transporter superfamily
BG553_RS12460	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BG553_RS12460	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BG553_RS12465	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BG553_RS12475	COG2801	Transposase and inactivated derivatives
BG553_RS12480	COG0616	signal peptide processing
BG553_RS12500	COG2801	Transposase and inactivated derivatives
BG553_RS12540	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
BG553_RS12555	COG0174	glutamine synthetase
BG553_RS12560	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BG553_RS12570	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
BG553_RS12580	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BG553_RS12600	COG0085	RNA polymerase activity
BG553_RS12615	COG2168	tRNA wobble position uridine thiolation
BG553_RS12625	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
BG553_RS12630	COG2964	Protein conserved in bacteria
BG553_RS12635	COG0545	Peptidyl-prolyl cis-trans isomerase
BG553_RS12640	COG2900	Belongs to the SlyX family
BG553_RS12650	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BG553_RS12655	COG3914	O-linked N-acetylglucosamine transferase SPINDLY family
BG553_RS12665	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
BG553_RS12670	COG1328	CTP reductase activity
BG553_RS12685	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BG553_RS12695	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BG553_RS12705	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BG553_RS12710	COG1028	Short-chain dehydrogenase reductase Sdr
BG553_RS12725	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BG553_RS12740	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BG553_RS12750	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BG553_RS12770	COG0758	DNA mediated transformation
BG553_RS12785	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BG553_RS12790	COG1067	ATP-dependent peptidase activity
BG553_RS12795	COG3120	sequence-specific DNA binding
BG553_RS12805	COG0277	FAD linked oxidase domain protein
BG553_RS12805	COG0247	lactate metabolic process
BG553_RS12810	COG2050	protein possibly involved in aromatic compounds catabolism
BG553_RS12825	COG0204	Acyl-transferase
BG553_RS12835	COG0825	malonyl-CoA metabolic process
BG553_RS12855	COG2801	Transposase and inactivated derivatives
BG553_RS12865	COG0235	Class ii aldolase
BG553_RS12870	COG3623	hexulose-6-phosphate isomerase
BG553_RS12890	COG0737	Belongs to the 5'-nucleotidase family
BG553_RS12910	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
BG553_RS12915	COG1929	Belongs to the glycerate kinase type-1 family
BG553_RS12920	COG2610	gluconate transmembrane transporter activity
BG553_RS12925	COG3835	regulator
BG553_RS12940	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BG553_RS12945	COG0840	transmembrane signaling receptor activity
BG553_RS12970	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
BG553_RS12980	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
BG553_RS12990	COG0089	rRNA binding
BG553_RS12995	COG0088	Forms part of the polypeptide exit tunnel
BG553_RS13000	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BG553_RS13005	COG0051	transcription antitermination factor activity, RNA binding
BG553_RS13010	COG3070	regulator of competence-specific genes
BG553_RS13025	COG0019	diaminopimelate decarboxylase activity
BG553_RS13030	COG0625	glutathione transferase activity
BG553_RS13040	COG2264	protein methyltransferase activity
BG553_RS13095	COG3161	chorismate lyase activity
BG553_RS13105	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
BG553_RS13120	COG0442	prolyl-tRNA aminoacylation
BG553_RS13145	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BG553_RS13155	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BG553_RS13160	COG1192	Involved in chromosome partitioning
BG553_RS13190	COG3676	manually curated
BG553_RS13220	COG3012	SEC-C Motif Domain Protein