locus-tag	class	description
N220_RS00005	COG0445	tRNA wobble uridine modification
N220_RS00015	COG0357	Ribosomal RNA small subunit methyltransferase G
N220_RS00020	COG2211	Major facilitator Superfamily
N220_RS00030	COG0667	Aldo Keto reductase
N220_RS00035	COG2271	Major facilitator Superfamily
N220_RS00040	COG0584	glycerophosphoryl diester phosphodiesterase
N220_RS00045	COG2271	Major facilitator Superfamily
N220_RS00090	COG1129	ABC transporter
N220_RS00095	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
N220_RS00100	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
N220_RS00105	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
N220_RS00110	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
N220_RS00115	COG2731	YhcH YjgK YiaL family protein
N220_RS00120	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
N220_RS00125	COG2160	L-arabinose isomerase activity
N220_RS00155	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
N220_RS00160	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
N220_RS00185	COG2502	aspartate--ammonia ligase
N220_RS00190	COG1522	sequence-specific DNA binding
N220_RS00195	COG0716	FMN binding
N220_RS00200	COG0747	negative chemotaxis
N220_RS00210	COG5301	cellulose 1,4-beta-cellobiosidase activity
N220_RS00245	COG2801	Transposase and inactivated derivatives
N220_RS00250	COG3423	Transcriptional regulator
N220_RS00255	COG2932	Transcriptional regulator
N220_RS00280	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
N220_RS00295	COG0259	pyridoxamine-phosphate oxidase activity
N220_RS00305	COG3276	selenocysteine insertion sequence binding
N220_RS00310	COG2358	TRAP transporter, solute receptor (TAXI family
N220_RS00325	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
N220_RS00330	COG0569	domain protein
N220_RS00335	COG3477	response to acidic pH
N220_RS00340	COG1012	belongs to the aldehyde dehydrogenase family
N220_RS00345	COG1454	alcohol dehydrogenase
N220_RS00350	COG1263	PTS System
N220_RS00350	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
N220_RS00355	COG1879	ABC-type sugar transport system periplasmic component
N220_RS00360	COG1172	Belongs to the binding-protein-dependent transport system permease family
N220_RS00365	COG1129	ABC transporter
N220_RS00370	COG0235	Class ii aldolase
N220_RS00375	COG4154	Belongs to the RbsD FucU family
N220_RS00380	COG1070	Carbohydrate kinase
N220_RS00385	COG2407	Converts the aldose L-fucose into the corresponding ketose L-fuculose
N220_RS00390	COG1349	DNA-binding transcription factor activity
N220_RS00425	COG1629	transport
N220_RS00425	COG4206	TonB-dependent receptor
N220_RS00435	COG0252	asparaginase activity
N220_RS00440	COG3676	manually curated
N220_RS00450	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
N220_RS00455	COG1595	DNA-templated transcription, initiation
N220_RS00470	COG0673	inositol 2-dehydrogenase activity
N220_RS00475	COG1305	Transglutaminase-like
N220_RS00485	COG2608	mercury ion transmembrane transporter activity
N220_RS00490	COG3730	PTS system glucitol sorbitol-specific
N220_RS00505	COG1028	Short-chain dehydrogenase reductase Sdr
N220_RS00510	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
N220_RS00515	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
N220_RS00520	COG1349	DNA-binding transcription factor activity
N220_RS00525	COG0517	IMP dehydrogenase activity
N220_RS00525	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
N220_RS00550	COG3722	fumarate hydratase activity
N220_RS00555	COG0490	domain, Protein
N220_RS00555	COG0471	metal ion transport
N220_RS00565	COG1396	sequence-specific DNA binding
N220_RS00570	COG3423	Transcriptional regulator
N220_RS00575	COG2801	Transposase and inactivated derivatives
N220_RS00580	COG4214	carbohydrate transport
N220_RS00585	COG1129	ABC transporter
N220_RS00590	COG4213	ABC transporter substrate-binding protein
N220_RS00595	COG2115	Belongs to the xylose isomerase family
N220_RS00600	COG1070	Carbohydrate kinase
N220_RS00610	COG3545	Serine hydrolase
N220_RS00620	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
N220_RS00625	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
N220_RS00630	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
N220_RS00635	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
N220_RS00650	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
N220_RS00705	COG0697	spore germination
N220_RS00710	COG0346	lactoylglutathione lyase activity
N220_RS00715	COG1194	a g-specific adenine glycosylase
N220_RS00720	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
N220_RS00725	COG0741	lytic transglycosylase activity
N220_RS00750	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
N220_RS00755	COG1349	DNA-binding transcription factor activity
N220_RS00760	COG2084	Dehydrogenase
N220_RS00765	COG3395	kinase activity
N220_RS00770	COG0235	Class ii aldolase
N220_RS00775	COG3622	Belongs to the hyi family
N220_RS00780	COG2610	gluconate transmembrane transporter activity
N220_RS00790	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
N220_RS00815	COG4545	Glutaredoxin-related protein
N220_RS00820	COG4804	nuclease activity
N220_RS00840	COG0814	amino acid
N220_RS00845	COG2964	Protein conserved in bacteria
N220_RS00860	COG2832	Protein of unknown function (DUF454)
N220_RS00880	COG3085	chromosome segregation
N220_RS00890	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
N220_RS00900	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
N220_RS00910	COG0521	Mo-molybdopterin cofactor biosynthetic process
N220_RS00930	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
N220_RS00975	COG1840	ABC-type Fe3 transport system, periplasmic component
N220_RS00985	COG1349	DNA-binding transcription factor activity
N220_RS00990	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
N220_RS01010	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
N220_RS01020	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
N220_RS01030	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
N220_RS01040	COG0200	Binds to the 23S rRNA
N220_RS01045	COG0201	protein transport
N220_RS01055	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
N220_RS01065	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
N220_RS01070	COG0202	RNA polymerase activity
N220_RS01075	COG0203	ribosomal protein L17
N220_RS01080	COG2207	Transcriptional regulator
N220_RS01080	COG1609	Transcriptional regulator
N220_RS01085	COG1609	Transcriptional regulator
N220_RS01090	COG3265	gluconokinase activity
N220_RS01095	COG2610	gluconate transmembrane transporter activity
N220_RS01100	COG0583	DNA-binding transcription factor activity
N220_RS01110	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
N220_RS01115	COG1012	belongs to the aldehyde dehydrogenase family
N220_RS01120	COG3718	enzyme involved in inositol metabolism
N220_RS01135	COG1129	ABC transporter
N220_RS01140	COG1172	Belongs to the binding-protein-dependent transport system permease family
N220_RS01145	COG0673	inositol 2-dehydrogenase activity
N220_RS01160	COG0673	inositol 2-dehydrogenase activity
N220_RS01170	COG3962	Belongs to the TPP enzyme family
N220_RS01185	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
N220_RS01195	COG2190	(PTS) system
N220_RS01195	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
N220_RS01195	COG1263	PTS System
N220_RS01205	COG0228	four-way junction DNA binding
N220_RS01215	COG0336	Belongs to the RNA methyltransferase TrmD family
N220_RS01235	COG1694	Mazg nucleotide pyrophosphohydrolase
N220_RS01240	COG2850	peptidyl-arginine hydroxylation
N220_RS01245	COG0439	Biotin carboxylase
N220_RS01250	COG0511	ligase activity, forming carbon-carbon bonds
N220_RS01260	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
N220_RS01275	COG1876	peptidase activity
N220_RS01285	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
N220_RS01290	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
N220_RS01300	COG0606	chelatase, subunit chli
N220_RS01310	COG0210	DNA helicase
N220_RS01345	COG1475	DNA binding
N220_RS01350	COG2801	Transposase and inactivated derivatives
N220_RS01385	COG0606	chelatase, subunit chli
N220_RS01390	COG2267	carboxylic ester hydrolase activity
N220_RS01400	COG1216	Glycosyl transferase, family 2
N220_RS01400	COG1442	glycosyl transferase family 8
N220_RS01405	COG3691	Protein conserved in bacteria
N220_RS01415	COG1879	ABC-type sugar transport system periplasmic component
N220_RS01425	COG0675	Transposase, IS605 OrfB family
N220_RS01430	COG1879	ABC-type sugar transport system periplasmic component
N220_RS01440	COG4211	Belongs to the binding-protein-dependent transport system permease family
N220_RS01445	COG0747	negative chemotaxis
N220_RS01450	COG3676	manually curated
N220_RS01460	COG1757	Na H antiporter
N220_RS01465	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
N220_RS01470	COG3676	manually curated
N220_RS01475	COG0747	negative chemotaxis
N220_RS01490	COG4795	General secretion pathway protein
N220_RS01505	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
N220_RS01515	COG0747	negative chemotaxis
N220_RS01535	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
N220_RS01535	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
N220_RS01540	COG0812	UDP-N-acetylmuramate dehydrogenase activity
N220_RS01555	COG1309	transcriptional regulator
N220_RS01580	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
N220_RS01585	COG2003	Belongs to the UPF0758 family
N220_RS01600	COG1349	DNA-binding transcription factor activity
N220_RS01605	COG3395	kinase activity
N220_RS01615	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
N220_RS01620	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
N220_RS01625	COG0076	glutamate decarboxylase activity
N220_RS01630	COG3111	PFAM Bacterial OB fold (BOF) protein
N220_RS01635	COG2249	NAD(P)H dehydrogenase (quinone) activity
N220_RS01640	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
N220_RS01645	COG3062	negative regulation of establishment of protein localization
N220_RS01650	COG0243	molybdopterin cofactor binding
N220_RS01655	COG0437	4 iron, 4 sulfur cluster binding
N220_RS01660	COG0348	domain, Protein
N220_RS01665	COG3043	anaerobic respiration
N220_RS01670	COG3005	denitrification pathway
N220_RS01675	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
N220_RS01685	COG3005	denitrification pathway
N220_RS01695	COG3381	protein complex oligomerization
N220_RS01715	COG2801	Transposase and inactivated derivatives
N220_RS01720	COG0494	nUDIX hydrolase
N220_RS01740	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
N220_RS01745	COG4145	pantothenate transmembrane transporter activity
N220_RS01750	COG3924	membrane
N220_RS01755	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
N220_RS01760	COG2853	Lipoprotein
N220_RS01765	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
N220_RS01775	COG1858	cytochrome C peroxidase
N220_RS01805	COG1309	transcriptional regulator
N220_RS01810	COG0583	DNA-binding transcription factor activity
N220_RS01815	COG0678	peroxiredoxin activity
N220_RS01815	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
N220_RS01820	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
N220_RS01825	COG1803	Methylglyoxal synthase
N220_RS01830	COG1289	transmembrane transporter activity
N220_RS01845	COG2995	paraquat-inducible protein a
N220_RS01850	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
N220_RS01870	COG0416	fatty acid biosynthetic process
N220_RS01880	COG1399	metal-binding, possibly nucleic acid-binding protein
N220_RS01885	COG4137	Cytochrome C assembly protein
N220_RS01890	COG4536	flavin adenine dinucleotide binding
N220_RS01895	COG0733	neurotransmitter:sodium symporter activity
N220_RS01905	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
N220_RS01910	COG0513	Belongs to the DEAD box helicase family
N220_RS01915	COG3691	Protein conserved in bacteria
N220_RS01920	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
N220_RS01925	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
N220_RS01930	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
N220_RS01935	COG3084	Protein conserved in bacteria
N220_RS01950	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
N220_RS01955	COG0676	glucose-6-phosphate 1-epimerase activity
N220_RS01965	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
N220_RS01970	COG0024	Methionine aminopeptidase
N220_RS01985	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
N220_RS01990	COG1178	ABC-type Fe3 transport system permease component
N220_RS01995	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
N220_RS02000	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
N220_RS02005	COG2190	(PTS) system
N220_RS02010	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
N220_RS02015	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
N220_RS02020	COG1621	beta-fructofuranosidase activity
N220_RS02035	COG1758	RNA polymerase activity
N220_RS02040	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
N220_RS02055	COG0230	Belongs to the bacterial ribosomal protein bL34 family
N220_RS02060	COG0594	ribonuclease P activity
N220_RS02065	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
N220_RS02075	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
N220_RS02090	COG1216	Glycosyl transferase, family 2
N220_RS02100	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
N220_RS02110	COG1088	dTDP-glucose 4,6-dehydratase activity
N220_RS02115	COG3307	-O-antigen
N220_RS02135	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
N220_RS02145	COG1575	Belongs to the MenA family. Type 1 subfamily
N220_RS02150	COG1720	tRNA m6t6A37 methyltransferase activity
N220_RS02160	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
N220_RS02165	COG1047	Peptidyl-prolyl cis-trans
N220_RS02175	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
N220_RS02180	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
N220_RS02185	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
N220_RS02195	COG0745	RESPONSE REGULATOR receiver
N220_RS02200	COG2129	metallophosphoesterase
N220_RS02205	COG3172	ATPase kinase involved in NAD metabolism
N220_RS02210	COG0196	riboflavin kinase activity
N220_RS02215	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
N220_RS02225	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
N220_RS02230	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
N220_RS02235	COG4172	Belongs to the ABC transporter superfamily
N220_RS02240	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
N220_RS02245	COG0601	transmembrane transport
N220_RS02250	COG0747	negative chemotaxis
N220_RS02260	COG1686	Belongs to the peptidase S11 family
N220_RS02275	COG1620	l-lactate permease
N220_RS02280	COG0247	lactate metabolic process
N220_RS02285	COG1139	Iron-sulfur cluster binding protein
N220_RS02290	COG1556	Lactate utilization protein
N220_RS02310	COG1561	YicC-like family, N-terminal region
N220_RS02315	COG0354	folic acid binding
N220_RS02320	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
N220_RS02330	COG1129	ABC transporter
N220_RS02335	COG1172	Belongs to the binding-protein-dependent transport system permease family
N220_RS02340	COG1879	ABC-type sugar transport system periplasmic component
N220_RS02345	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
N220_RS02350	COG1609	Transcriptional regulator
N220_RS02355	COG2197	response regulator
N220_RS02365	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
N220_RS02380	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
N220_RS02390	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
N220_RS02395	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
N220_RS02400	COG5016	pyruvate
N220_RS02400	COG0511	ligase activity, forming carbon-carbon bonds
N220_RS02405	COG3630	sodium ion export across plasma membrane
N220_RS02410	COG1914	H( )-stimulated, divalent metal cation uptake system
N220_RS02415	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
N220_RS02420	COG1984	allophanate hydrolase subunit 2
N220_RS02425	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
N220_RS02430	COG1793	dna ligase
N220_RS02475	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
N220_RS02485	COG0006	proline dipeptidase activity
N220_RS02490	COG3030	protein affecting phage T7 exclusion by the F plasmid
N220_RS02500	COG1187	pseudouridine synthase activity
N220_RS02515	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
N220_RS02525	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
N220_RS02530	COG5413	integral membrane protein
N220_RS02550	COG4166	transmembrane transport
N220_RS02555	COG1254	Belongs to the acylphosphatase family
N220_RS02560	COG0308	aminopeptidase N
N220_RS02565	COG0748	coenzyme F420 binding
N220_RS02585	COG0814	amino acid
N220_RS02590	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
N220_RS02610	COG1487	ribonuclease activity
N220_RS02645	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
N220_RS02650	COG1108	ABC-type Mn2 Zn2 transport systems permease components
N220_RS02655	COG1108	ABC-type Mn2 Zn2 transport systems permease components
N220_RS02660	COG1121	(ABC) transporter
N220_RS02685	COG3063	Type IV pilus biogenesis stability protein PilW
N220_RS02690	COG2183	response to ionizing radiation
N220_RS02695	COG0778	Nitroreductase
N220_RS02700	COG0616	signal peptide processing
N220_RS02720	COG0477	Major facilitator Superfamily
N220_RS02740	COG3978	acetolactate synthase activity
N220_RS02755	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
N220_RS02760	COG0437	4 iron, 4 sulfur cluster binding
N220_RS02765	COG3301	Polysulphide reductase, NrfD
N220_RS02770	COG1138	Cytochrome C-type biogenesis protein
N220_RS02775	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
N220_RS02780	COG4235	cytochrome complex assembly
N220_RS02780	COG3088	subunit of a heme lyase
N220_RS02790	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
N220_RS02795	COG1127	ABC transporter
N220_RS02800	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
N220_RS02805	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
N220_RS02810	COG2854	intermembrane phospholipid transfer
N220_RS02820	COG5007	Belongs to the BolA IbaG family
N220_RS02825	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
N220_RS02830	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
N220_RS02845	COG0494	nUDIX hydrolase
N220_RS02870	COG3423	Transcriptional regulator
N220_RS02875	COG2801	Transposase and inactivated derivatives
N220_RS02885	COG2842	Transposition protein
N220_RS02905	COG4396	Host-nuclease inhibitor protein Gam
N220_RS02925	COG4382	Mu-like prophage protein Gp16
N220_RS02960	COG0640	Transcriptional regulator
N220_RS02970	COG4373	Mu-like prophage FluMu protein gp28
N220_RS02990	COG5005	Phage virion morphogenesis
N220_RS03110	COG3392	D12 class N6 adenine-specific DNA methyltransferase
N220_RS03125	COG2431	L-lysine efflux transmembrane transporter activity
N220_RS03135	COG0501	Belongs to the peptidase M48B family
N220_RS03140	COG1238	metal cluster binding
N220_RS03145	COG2116	formate transmembrane transporter activity
N220_RS03150	COG1882	Formate acetyltransferase
N220_RS03160	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
N220_RS03165	COG0339	signal peptide processing
N220_RS03170	COG0077	Prephenate dehydratase
N220_RS03170	COG1605	Chorismate mutase
N220_RS03175	COG2841	Protein conserved in bacteria
N220_RS03180	COG2268	Band 7 protein
N220_RS03190	COG4773	Receptor
N220_RS03200	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
N220_RS03215	COG1120	ATPase activity
N220_RS03220	COG2814	Major facilitator Superfamily
N220_RS03250	COG1120	ATPase activity
N220_RS03255	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
N220_RS03270	COG4206	TonB-dependent receptor
N220_RS03275	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
N220_RS03295	COG1663	tetraacyldisaccharide 4'-kinase activity
N220_RS03320	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
N220_RS03325	COG0740	serine-type endopeptidase activity
N220_RS03330	COG2166	iron-sulfur cluster assembly
N220_RS03340	COG2226	methyltransferase
N220_RS03350	COG1942	4-Oxalocrotonate Tautomerase
N220_RS03355	COG0512	Glutamine amidotransferase of anthranilate synthase
N220_RS03360	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
N220_RS03365	COG0009	L-threonylcarbamoyladenylate synthase
N220_RS03370	COG1187	pseudouridine synthase activity
N220_RS03375	COG3273	potassium ion transport
N220_RS03375	COG0471	metal ion transport
N220_RS03390	COG1640	4-alpha-glucanotransferase
N220_RS03415	COG2965	DNA replication, synthesis of RNA primer
N220_RS03435	COG0488	(ABC) transporter
N220_RS03455	COG4657	Part of a membrane complex involved in electron transport
N220_RS03460	COG2878	Part of a membrane complex involved in electron transport
N220_RS03465	COG4656	Part of a membrane complex involved in electron transport
N220_RS03470	COG2860	membrane
N220_RS03475	COG4658	electron transport chain
N220_RS03490	COG1560	Kdo2-lipid A biosynthetic process
N220_RS03495	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
N220_RS03500	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
N220_RS03505	COG1131	(ABC) transporter
N220_RS03510	COG0842	Transport permease protein
N220_RS03515	COG0725	ABC transporter, periplasmic molybdate-binding protein
N220_RS03520	COG4149	molybdate abc transporter
N220_RS03525	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
N220_RS03530	COG2867	negative regulation of translational initiation
N220_RS03535	COG2914	Belongs to the UPF0125 (RnfH) family
N220_RS03545	COG2195	Cleaves the N-terminal amino acid of tripeptides
N220_RS03560	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
N220_RS03565	COG0194	GDP metabolic process
N220_RS03570	COG1538	Outer membrane efflux protein
N220_RS03575	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
N220_RS03630	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
N220_RS03640	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
N220_RS03645	COG0488	(ABC) transporter
N220_RS03650	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
N220_RS03655	COG1611	Belongs to the LOG family
N220_RS03660	COG3593	DNA synthesis involved in DNA repair
N220_RS03665	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
N220_RS03695	COG4667	esterase of the alpha-beta hydrolase superfamily
N220_RS03705	COG3719	Belongs to the RNase T2 family
N220_RS03715	COG1252	NADH dehydrogenase
N220_RS03720	COG1840	ABC-type Fe3 transport system, periplasmic component
N220_RS03735	COG2252	PERMEase
N220_RS03740	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
N220_RS03745	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
N220_RS03750	COG1862	Preprotein translocase
N220_RS03755	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
N220_RS03760	COG2017	converts alpha-aldose to the beta-anomer
N220_RS03765	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
N220_RS03770	COG1085	galactose-1-phosphate uridylyltransferase
N220_RS03780	COG3739	integral membrane protein
N220_RS03785	COG1408	metallophosphoesterase
N220_RS03810	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
N220_RS03815	COG2801	Transposase and inactivated derivatives
N220_RS03825	COG0709	Synthesizes selenophosphate from selenide and ATP
N220_RS03835	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
N220_RS03840	COG2233	PERMEase
N220_RS03850	COG4316	Uncharacterized protein conserved in bacteria (DUF2251)
N220_RS03855	COG0148	phosphopyruvate hydratase activity
N220_RS03860	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
N220_RS03865	COG1472	Belongs to the glycosyl hydrolase 3 family
N220_RS03870	COG0861	Integral membrane protein TerC family
N220_RS03890	COG1584	GPR1 FUN34 yaaH family protein
N220_RS03900	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
N220_RS03905	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
N220_RS03920	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
N220_RS03920	COG2190	(PTS) system
N220_RS03920	COG1263	PTS System
N220_RS03930	COG2920	part of a sulfur-relay system
N220_RS03935	COG0670	Belongs to the BI1 family
N220_RS03940	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
N220_RS03955	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
N220_RS03960	COG0291	Belongs to the bacterial ribosomal protein bL35 family
N220_RS03965	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
N220_RS03975	COG1965	Belongs to the frataxin family
N220_RS03990	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
N220_RS03995	COG0564	pseudouridine synthase activity
N220_RS04005	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
N220_RS04010	COG1560	Kdo2-lipid A biosynthetic process
N220_RS04015	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
N220_RS04020	COG0814	amino acid
N220_RS04025	COG1760	l-serine dehydratase
N220_RS04040	COG2027	D-alanyl-D-alanine carboxypeptidase
N220_RS04045	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
N220_RS04060	COG1441	menaquinone biosynthetic process
N220_RS04070	COG2814	Major facilitator Superfamily
N220_RS04075	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
N220_RS04080	COG0232	Belongs to the dGTPase family. Type 2 subfamily
N220_RS04105	COG0564	pseudouridine synthase activity
N220_RS04110	COG3023	N-Acetylmuramoyl-L-alanine amidase
N220_RS04115	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
N220_RS04130	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
N220_RS04135	COG0626	cystathionine gamma-synthase activity
N220_RS04140	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
N220_RS04155	COG1702	phosphate starvation-inducible protein PhoH
N220_RS04180	COG0583	DNA-binding transcription factor activity
N220_RS04185	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
N220_RS04210	COG0815	Transfers the fatty acyl group on membrane lipoproteins
N220_RS04230	COG3381	protein complex oligomerization
N220_RS04240	COG0791	NLP P60 protein
N220_RS04245	COG2932	Transcriptional regulator
N220_RS04255	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
N220_RS04260	COG0330	HflC and HflK could
N220_RS04275	COG1643	Atp-dependent helicase
N220_RS04295	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
N220_RS04300	COG0534	Mate efflux family protein
N220_RS04305	COG1074	ATP-dependent DNA helicase activity
N220_RS04320	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
N220_RS04330	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
N220_RS04335	COG0561	phosphatase activity
N220_RS04345	COG1595	DNA-templated transcription, initiation
N220_RS04350	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
N220_RS04355	COG3026	antisigma factor binding
N220_RS04365	COG0318	PFAM AMP-dependent synthetase and ligase
N220_RS04370	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
N220_RS04375	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
N220_RS04380	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
N220_RS04385	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
N220_RS04390	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
N220_RS04390	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
N220_RS04395	COG1160	GTP binding
N220_RS04405	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
N220_RS04415	COG1757	Na H antiporter
N220_RS04420	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
N220_RS04425	COG4172	Belongs to the ABC transporter superfamily
N220_RS04430	COG0444	Belongs to the ABC transporter superfamily
N220_RS04440	COG4166	transmembrane transport
N220_RS04445	COG0635	Involved in the biosynthesis of porphyrin-containing compound
N220_RS04455	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
N220_RS04460	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
N220_RS04465	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
N220_RS04465	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
N220_RS04470	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
N220_RS04485	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
N220_RS04495	COG2840	Smr protein MutS2
N220_RS04500	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
N220_RS04510	COG0697	spore germination
N220_RS04530	COG2801	Transposase and inactivated derivatives
N220_RS04535	COG0676	glucose-6-phosphate 1-epimerase activity
N220_RS04545	COG1763	Mo-molybdopterin cofactor biosynthetic process
N220_RS04550	COG3084	Protein conserved in bacteria
N220_RS04555	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
N220_RS04560	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
N220_RS04570	COG3691	Protein conserved in bacteria
N220_RS04575	COG2801	Transposase and inactivated derivatives
N220_RS04590	COG2801	Transposase and inactivated derivatives
N220_RS04610	COG2801	Transposase and inactivated derivatives
N220_RS04615	COG1192	Involved in chromosome partitioning
N220_RS04645	COG4608	Belongs to the ABC transporter superfamily
N220_RS04660	COG0500	methyltransferase
N220_RS04665	COG2830	Protein of unknown function (DUF452)
N220_RS04675	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
N220_RS04685	COG0545	Peptidyl-prolyl cis-trans isomerase
N220_RS04780	COG2801	Transposase and inactivated derivatives
N220_RS04850	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
N220_RS04855	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
N220_RS04880	COG2198	Histidine kinase
N220_RS04880	COG0784	Response regulator, receiver
N220_RS04880	COG5002	protein histidine kinase activity
N220_RS04885	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
N220_RS04895	COG1959	2 iron, 2 sulfur cluster binding
N220_RS04905	COG0822	iron-sulfur transferase activity
N220_RS04915	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
N220_RS04925	COG2852	Protein conserved in bacteria
N220_RS04940	COG0633	Ferredoxin
N220_RS04945	COG2975	iron-sulfur cluster assembly
N220_RS04950	COG1275	C4-dicarboxylate transporter malic acid transport protein
N220_RS04955	COG0617	tRNA 3'-terminal CCA addition
N220_RS04960	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
N220_RS04965	COG0730	response to heat
N220_RS04970	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
N220_RS04975	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
N220_RS04980	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
N220_RS04990	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
N220_RS04995	COG4969	Belongs to the N-Me-Phe pilin family
N220_RS05000	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
N220_RS05005	COG1459	type II secretion system
N220_RS05015	COG0237	dephospho-CoA kinase activity
N220_RS05015	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
N220_RS05020	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
N220_RS05025	COG1466	dna polymerase III delta subunit
N220_RS05030	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
N220_RS05035	COG0495	leucyl-tRNA aminoacylation
N220_RS05055	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
N220_RS05070	COG3106	COG3106 Predicted ATPase
N220_RS05075	COG3025	triphosphatase activity
N220_RS05085	COG0564	pseudouridine synthase activity
N220_RS05090	COG3098	single-species biofilm formation
N220_RS05095	COG0135	phosphoribosylanthranilate isomerase activity
N220_RS05095	COG0134	indole-3-glycerol-phosphate synthase activity
N220_RS05100	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
N220_RS05100	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
N220_RS05105	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
N220_RS05110	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
N220_RS05115	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
N220_RS05130	COG0750	zinc metalloprotease
N220_RS05135	COG0575	Belongs to the CDS family
N220_RS05140	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
N220_RS05145	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
N220_RS05150	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
N220_RS05160	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
N220_RS05185	COG1704	LemA family
N220_RS05200	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
N220_RS05200	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
N220_RS05200	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
N220_RS05205	COG1105	Belongs to the carbohydrate kinase PfkB family
N220_RS05210	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
N220_RS05210	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
N220_RS05215	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
N220_RS05220	COG1523	belongs to the glycosyl hydrolase 13 family
N220_RS05235	COG0058	SHG alpha-glucan phosphorylase activity
N220_RS05240	COG0058	SHG alpha-glucan phosphorylase activity
N220_RS05245	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
N220_RS05250	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
N220_RS05255	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
N220_RS05260	COG0583	DNA-binding transcription factor activity
N220_RS05265	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
N220_RS05280	COG0675	Transposase, IS605 OrfB family
N220_RS05320	COG1518	maintenance of DNA repeat elements
N220_RS05330	COG1530	ribonuclease E activity
N220_RS05335	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
N220_RS05420	COG3728	DNA packaging
N220_RS05425	COG1783	phage Terminase large subunit
N220_RS05445	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
N220_RS05555	COG3683	transport system, periplasmic component
N220_RS05560	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
N220_RS05565	COG1115	amino acid carrier protein
N220_RS05570	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
N220_RS05575	COG0045	succinate-CoA ligase (ADP-forming) activity
N220_RS05580	COG0508	dehydrogenase complex catalyzes the overall conversion of
N220_RS05585	COG0567	Dehydrogenase, E1 component
N220_RS05590	COG1121	(ABC) transporter
N220_RS05595	COG0739	heme binding
N220_RS05600	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
N220_RS05605	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
N220_RS05615	COG0561	phosphatase activity
N220_RS05620	COG3850	Histidine kinase
N220_RS05630	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
N220_RS05635	COG0393	Putative heavy-metal-binding
N220_RS05640	COG2983	Belongs to the UPF0260 family
N220_RS05645	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
N220_RS05650	COG3283	Transcriptional regulator of aromatic amino acids metabolism
N220_RS05655	COG4166	transmembrane transport
N220_RS05660	COG4168	peptide transport system, permease
N220_RS05665	COG4171	peptide transport system, permease
N220_RS05670	COG4172	Belongs to the ABC transporter superfamily
N220_RS05675	COG5645	(Lipo)protein
N220_RS05690	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
N220_RS05695	COG4695	Portal protein
N220_RS05745	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
N220_RS05775	COG2801	Transposase and inactivated derivatives
N220_RS05800	COG5301	cellulose 1,4-beta-cellobiosidase activity
N220_RS05860	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
N220_RS05915	COG0629	single-stranded DNA binding
N220_RS05950	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
N220_RS05970	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
N220_RS05980	COG0589	response to stress
N220_RS05990	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
N220_RS05995	COG1210	Utp--glucose-1-phosphate uridylyltransferase
N220_RS06005	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
N220_RS06010	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
N220_RS06015	COG2814	Major facilitator Superfamily
N220_RS06020	COG2814	Major facilitator Superfamily
N220_RS06025	COG3083	sulfuric ester hydrolase activity
N220_RS06035	COG1309	transcriptional regulator
N220_RS06040	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
N220_RS06045	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
N220_RS06055	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
N220_RS06070	COG3105	Protein conserved in bacteria
N220_RS06075	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
N220_RS06105	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
N220_RS06110	COG1823	symporter activity
N220_RS06115	COG0778	Nitroreductase
N220_RS06125	COG0072	phenylalanine-tRNA ligase activity
N220_RS06135	COG0791	NLP P60 protein
N220_RS06140	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
N220_RS06145	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
N220_RS06150	COG0539	negative regulation of cytoplasmic translation
N220_RS06160	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
N220_RS06165	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
N220_RS06170	COG0284	orotidine-5'-phosphate decarboxylase activity
N220_RS06175	COG0023	Translation Initiation Factor
N220_RS06180	COG0741	lytic transglycosylase activity
N220_RS06195	COG0779	Required for maturation of 30S ribosomal subunits
N220_RS06200	COG0195	Participates in both transcription termination and antitermination
N220_RS06205	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
N220_RS06210	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
N220_RS06215	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
N220_RS06225	COG2951	lytic endotransglycosylase activity
N220_RS06230	COG0590	tRNA wobble adenosine to inosine editing
N220_RS06235	COG0513	Belongs to the DEAD box helicase family
N220_RS06240	COG4785	May be involved in cell division
N220_RS06250	COG5002	protein histidine kinase activity
N220_RS06255	COG0745	RESPONSE REGULATOR receiver
N220_RS06280	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
N220_RS06285	COG0527	aspartate kinase activity
N220_RS06290	COG1263	PTS System
N220_RS06290	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
N220_RS06290	COG2190	(PTS) system
N220_RS06295	COG2926	Belongs to the UPF0265 family
N220_RS06300	COG0248	Ppx GppA phosphatase
N220_RS06305	COG2731	YhcH YjgK YiaL family protein
N220_RS06310	COG1737	Transcriptional regulator
N220_RS06315	COG0737	Belongs to the 5'-nucleotidase family
N220_RS06320	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
N220_RS06325	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
N220_RS06330	COG0658	competence protein
N220_RS06330	COG2333	competence protein COMEC
N220_RS06345	COG2831	hemolysin activation secretion protein
N220_RS06350	COG3210	domain, Protein
N220_RS06390	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
N220_RS06395	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
N220_RS06400	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
N220_RS06405	COG0577	efflux transmembrane transporter activity
N220_RS06405	COG1136	(ABC) transporter
N220_RS06410	COG2801	Transposase and inactivated derivatives
N220_RS06420	COG3956	TIGRFAM MazG family protein
N220_RS06425	COG3956	TIGRFAM MazG family protein
N220_RS06430	COG3956	TIGRFAM MazG family protein
N220_RS06440	COG0285	dihydrofolate synthase activity
N220_RS06445	COG1448	Aminotransferase
N220_RS06450	COG1444	tRNA N-acetyltransferase activity
N220_RS06455	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
N220_RS06460	COG0314	molybdopterin synthase activity
N220_RS06465	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
N220_RS06470	COG0315	cyclic pyranopterin monophosphate synthase activity
N220_RS06480	COG2909	trisaccharide binding
N220_RS06485	COG3005	denitrification pathway
N220_RS06490	COG0243	molybdopterin cofactor binding
N220_RS06500	COG2189	Belongs to the N(4) N(6)-methyltransferase family
N220_RS06520	COG0538	isocitrate dehydrogenase activity
N220_RS06525	COG1049	propionate catabolic process, 2-methylcitrate cycle
N220_RS06530	COG0243	molybdopterin cofactor binding
N220_RS06540	COG2363	Small membrane protein
N220_RS06565	COG0626	cystathionine gamma-synthase activity
N220_RS06590	COG4128	Pfam Zonular occludens toxin
N220_RS06600	COG2801	Transposase and inactivated derivatives
N220_RS06630	COG0737	Belongs to the 5'-nucleotidase family
N220_RS06640	COG0857	belongs to the CobB CobQ family
N220_RS06640	COG0280	phosphate acetyltransferase
N220_RS06645	COG0288	reversible hydration of carbon dioxide
N220_RS06650	COG0028	Belongs to the TPP enzyme family
N220_RS06655	COG0440	acetolactate synthase activity
N220_RS06660	COG0697	spore germination
N220_RS06665	COG2801	Transposase and inactivated derivatives
N220_RS06670	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
N220_RS06670	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
N220_RS06680	COG0006	proline dipeptidase activity
N220_RS06695	COG3074	FtsZ-dependent cytokinesis
N220_RS06700	COG1435	thymidine kinase activity
N220_RS06705	COG0641	radical SAM
N220_RS06710	COG3119	arylsulfatase activity
N220_RS06715	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
N220_RS06720	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
N220_RS06725	COG0730	response to heat
N220_RS06730	COG1214	PFAM Peptidase M22, glycoprotease
N220_RS06735	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
N220_RS06740	COG2321	neutral zinc metallopeptidase
N220_RS06745	COG1674	ftsk spoiiie
N220_RS06750	COG1522	sequence-specific DNA binding
N220_RS06755	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
N220_RS06760	COG1846	Transcriptional regulator
N220_RS06760	COG1940	carbohydrate kinase activity
N220_RS06765	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
N220_RS06770	COG3036	rescue of stalled ribosome
N220_RS06775	COG2226	methyltransferase
N220_RS06790	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
N220_RS06795	COG0583	DNA-binding transcription factor activity
N220_RS06810	COG2969	positive regulation of protein catabolic process
N220_RS06815	COG0625	glutathione transferase activity
N220_RS06820	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
N220_RS06830	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
N220_RS06840	COG0556	nucleotide-excision repair
N220_RS06855	COG2837	iron assimilation
N220_RS06870	COG0613	PHP domain protein
N220_RS06880	COG2925	Exonuclease
N220_RS06970	COG1724	mRNA binding
N220_RS06975	COG1598	PFAM Uncharacterised protein family UPF0150
N220_RS07035	COG1783	phage Terminase large subunit
N220_RS07040	COG3728	DNA packaging
N220_RS07100	COG0305	Participates in initiation and elongation during chromosome replication
N220_RS07135	COG2801	Transposase and inactivated derivatives
N220_RS07230	COG0582	viral genome integration into host DNA
N220_RS07235	COG0017	Asparaginyl-tRNA synthetase
N220_RS07240	COG1509	lysine 2,3-aminomutase activity
N220_RS07250	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
N220_RS07270	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
N220_RS07280	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
N220_RS07285	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
N220_RS07295	COG0251	oxidation-reduction process
N220_RS07300	COG1496	oxidoreductase activity
N220_RS07310	COG0582	viral genome integration into host DNA
N220_RS07410	COG4409	exo-alpha-(2->6)-sialidase activity
N220_RS07415	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
N220_RS07420	COG0312	modulator of DNA gyrase
N220_RS07425	COG3028	Belongs to the UPF0307 family
N220_RS07435	COG1811	Na channel or pump
N220_RS07445	COG3787	Belongs to the UPF0306 family
N220_RS07465	COG2801	Transposase and inactivated derivatives
N220_RS07475	COG2932	Transcriptional regulator
N220_RS07480	COG0425	Belongs to the sulfur carrier protein TusA family
N220_RS07485	COG3945	hemerythrin HHE cation binding domain
N220_RS07500	COG1278	Cold shock
N220_RS07505	COG0697	spore germination
N220_RS07525	COG1172	Belongs to the binding-protein-dependent transport system permease family
N220_RS07530	COG1172	Belongs to the binding-protein-dependent transport system permease family
N220_RS07545	COG0425	Belongs to the sulfur carrier protein TusA family
N220_RS07570	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
N220_RS07575	COG3100	YcgL domain-containing protein
N220_RS07580	COG0305	Participates in initiation and elongation during chromosome replication
N220_RS07585	COG4607	ABC-type enterochelin transport system periplasmic component
N220_RS07590	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
N220_RS07600	COG4604	ABC transporter, ATP-binding protein
N220_RS07615	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
N220_RS07620	COG1392	Phosphate transport regulator
N220_RS07625	COG0306	phosphate transporter
N220_RS07630	COG4991	sh3 domain protein
N220_RS07650	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
N220_RS07655	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
N220_RS07660	COG3676	manually curated
N220_RS07665	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
N220_RS07690	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
N220_RS07695	COG0508	dehydrogenase complex catalyzes the overall conversion of
N220_RS07700	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
N220_RS07705	COG0167	dihydroorotate dehydrogenase activity
N220_RS07710	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
N220_RS07725	COG1132	(ABC) transporter
N220_RS07730	COG1346	cytolysis
N220_RS07740	COG1199	ATP-dependent helicase activity
N220_RS07750	COG1122	ATPase activity
N220_RS07760	COG0659	secondary active sulfate transmembrane transporter activity
N220_RS07765	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
N220_RS07770	COG0629	single-stranded DNA binding
N220_RS07865	COG4453	Protein conserved in bacteria
N220_RS08025	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
N220_RS08070	COG0305	Participates in initiation and elongation during chromosome replication
N220_RS08095	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
N220_RS08110	COG1286	toxin biosynthetic process
N220_RS08115	COG0328	RNA-DNA hybrid ribonuclease activity
N220_RS08125	COG0859	PFAM glycosyl transferase family 9
N220_RS08130	COG0463	Glycosyl transferase, family 2
N220_RS08135	COG1534	Rna-binding protein
N220_RS08140	COG0671	phosphoesterase, PA-phosphatase related
N220_RS08155	COG1368	sulfuric ester hydrolase activity
N220_RS08160	COG3217	Mosc domain protein beta barrel domain protein
N220_RS08160	COG0633	Ferredoxin
N220_RS08165	COG1722	exodeoxyribonuclease VII activity
N220_RS08170	COG0142	geranyltranstransferase activity
N220_RS08175	COG0121	glutamine amidotransferase
N220_RS08180	COG1108	ABC-type Mn2 Zn2 transport systems permease components
N220_RS08185	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
N220_RS08190	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
N220_RS08195	COG1792	Involved in formation and maintenance of cell shape
N220_RS08200	COG1077	Cell shape determining protein MreB Mrl
N220_RS08210	COG0572	uridine kinase
N220_RS08215	COG0717	Belongs to the dCTP deaminase family
N220_RS08225	COG0586	Pfam SNARE associated Golgi protein
N220_RS08235	COG2226	methyltransferase
N220_RS08240	COG0596	Alpha beta hydrolase
N220_RS08250	COG0318	PFAM AMP-dependent synthetase and ligase
N220_RS08255	COG3264	Mechanosensitive ion channel
N220_RS08255	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
N220_RS08265	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
N220_RS08270	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
N220_RS08275	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
N220_RS08285	COG0582	viral genome integration into host DNA
N220_RS08300	COG0675	Transposase, IS605 OrfB family
N220_RS08320	COG1944	ATP diphosphatase activity
N220_RS08325	COG0500	methyltransferase
N220_RS08330	COG0187	DNA topoisomerase II activity
N220_RS08345	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
N220_RS08350	COG1349	DNA-binding transcription factor activity
N220_RS08355	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
N220_RS08360	COG2915	High frequency lysogenization protein hflD homolog
N220_RS08365	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
N220_RS08370	COG4988	ABC transporter
N220_RS08375	COG2911	Protein conserved in bacteria
N220_RS08380	COG0729	surface antigen
N220_RS08385	COG2861	carbohydrate metabolic process
N220_RS08390	COG4942	peptidase
N220_RS08400	COG0233	cytoplasmic translational termination
N220_RS08405	COG0528	UMP kinase activity
N220_RS08410	COG2194	sulfuric ester hydrolase activity
N220_RS08425	COG1840	ABC-type Fe3 transport system, periplasmic component
N220_RS08435	COG3842	ATPase activity
N220_RS08440	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
N220_RS08445	COG0433	COG0433 Predicted ATPase
N220_RS08450	COG0513	Belongs to the DEAD box helicase family
N220_RS08460	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
N220_RS08470	COG0681	Belongs to the peptidase S26 family
N220_RS08480	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
N220_RS08490	COG2801	Transposase and inactivated derivatives
N220_RS08495	COG2801	Transposase and inactivated derivatives
N220_RS08500	COG2259	Doxx family
N220_RS08515	COG3219	Protein conserved in bacteria
N220_RS08530	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
N220_RS08535	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
N220_RS08540	COG0635	Involved in the biosynthesis of porphyrin-containing compound
N220_RS08565	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
N220_RS08570	COG0732	type I restriction modification DNA specificity domain
N220_RS08575	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
N220_RS08585	COG2350	Protein conserved in bacteria
N220_RS08590	COG1607	acyl-coa hydrolase
N220_RS08595	COG2917	probably involved in intracellular septation
N220_RS08605	COG3092	negative regulation of chromosome organization
N220_RS08610	COG2932	Transcriptional regulator
N220_RS08615	COG3423	Transcriptional regulator
N220_RS08625	COG2842	Transposition protein
N220_RS08665	COG4382	Mu-like prophage protein Gp16
N220_RS08725	COG4383	Mu-like prophage protein gp29
N220_RS08735	COG5005	Phage virion morphogenesis
N220_RS08745	COG4397	Mu-like prophage major head subunit gpT
N220_RS08815	COG3299	homolog of phage Mu protein gp47
N220_RS08825	COG5301	cellulose 1,4-beta-cellobiosidase activity
N220_RS08840	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
N220_RS08845	COG0303	'Molybdopterin
N220_RS08850	COG2095	MarC family integral membrane protein
N220_RS08860	COG0488	(ABC) transporter
N220_RS08875	COG0564	pseudouridine synthase activity
N220_RS08890	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
N220_RS08900	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
N220_RS08915	COG0823	Involved in the tonB-independent uptake of proteins
N220_RS08920	COG3064	Membrane
N220_RS08925	COG0848	biopolymer transport protein
N220_RS08930	COG0811	peptide transport
N220_RS08935	COG0824	Thioesterase
N220_RS08945	COG1294	oxidase, subunit
N220_RS08950	COG1271	oxidase subunit
N220_RS08975	COG2801	Transposase and inactivated derivatives
N220_RS08980	COG0494	nUDIX hydrolase
N220_RS09010	COG0271	Belongs to the BolA IbaG family
N220_RS09025	COG1385	rRNA (uridine-N3-)-methyltransferase activity
N220_RS09030	COG1678	Uncharacterized ACR, COG1678
N220_RS09040	COG0628	permease
N220_RS09045	COG1115	amino acid carrier protein
N220_RS09050	COG1525	nuclease
N220_RS09080	COG3676	manually curated
N220_RS09115	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
N220_RS09120	COG0205	6-phosphofructokinase activity
N220_RS09130	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
N220_RS09130	COG0301	tRNA thio-modification
N220_RS09150	COG0629	single-stranded DNA binding
N220_RS09205	COG2801	Transposase and inactivated derivatives
N220_RS09210	COG0582	viral genome integration into host DNA
N220_RS09245	COG3077	Addiction module antitoxin, RelB DinJ family
N220_RS09320	COG0330	HflC and HflK could
N220_RS09325	COG0330	HflC and HflK could
N220_RS09340	COG0542	response to heat
N220_RS09345	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
N220_RS09350	COG0471	metal ion transport
N220_RS09355	COG0295	cytidine deaminase activity
N220_RS09365	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
N220_RS09375	COG0187	DNA topoisomerase II activity
N220_RS09390	COG0789	Transcriptional regulator
N220_RS09395	COG2608	mercury ion transmembrane transporter activity
N220_RS09410	COG0302	gtp cyclohydrolase
N220_RS09415	COG3642	lipopolysaccharide core region biosynthetic process
N220_RS09420	COG0489	protein tyrosine kinase activity
N220_RS09425	COG4166	transmembrane transport
N220_RS09430	COG2095	MarC family integral membrane protein
N220_RS09435	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
N220_RS09440	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
N220_RS09445	COG2354	Protein conserved in bacteria
N220_RS09450	COG3071	HemY protein
N220_RS09455	COG2959	enzyme of heme biosynthesis
N220_RS09465	COG0181	hydroxymethylbilane synthase activity
N220_RS09470	COG1454	alcohol dehydrogenase
N220_RS09470	COG1012	belongs to the aldehyde dehydrogenase family
N220_RS09480	COG0531	amino acid
N220_RS09490	COG0860	N-Acetylmuramoyl-L-alanine amidase
N220_RS09490	COG1388	LysM domain
N220_RS09495	COG0802	atpase or kinase
N220_RS09500	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
N220_RS09510	COG1519	Transferase
N220_RS09515	COG0826	peptidase U32
N220_RS09530	COG0795	lipopolysaccharide-transporting ATPase activity
N220_RS09535	COG0795	lipopolysaccharide-transporting ATPase activity
N220_RS09545	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
N220_RS09550	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
N220_RS09555	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
N220_RS09570	COG3711	transcriptional antiterminator
N220_RS09570	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
N220_RS09585	COG3716	PTS system mannose fructose sorbose family IID component
N220_RS09590	COG3715	PTS system
N220_RS09595	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
N220_RS09600	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
N220_RS09600	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
N220_RS09605	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
N220_RS09615	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
N220_RS09625	COG1902	pentaerythritol trinitrate reductase activity
N220_RS09635	COG1764	response to oxidative stress
N220_RS09640	COG2207	Transcriptional regulator
N220_RS09645	COG0813	purine-nucleoside phosphorylase activity
N220_RS09655	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
N220_RS09665	COG1216	Glycosyl transferase, family 2
N220_RS09670	COG1216	Glycosyl transferase, family 2
N220_RS09680	COG3306	glycosyltransferase involved in LPS biosynthesis
N220_RS09690	COG2244	polysaccharide biosynthetic process
N220_RS09705	COG2089	acid synthase
N220_RS09715	COG1434	Gram-negative-bacterium-type cell wall biogenesis
N220_RS09720	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
N220_RS09725	COG1280	lysine exporter protein (LysE YggA)
N220_RS09730	COG2962	Rard protein
N220_RS09735	COG0436	Aminotransferase
N220_RS09740	COG1169	isochorismate synthase
N220_RS09750	COG3676	manually curated
N220_RS09760	COG2801	Transposase and inactivated derivatives
N220_RS09765	COG0602	queuosine metabolic process
N220_RS09770	COG0720	synthase
N220_RS09780	COG2960	long-chain fatty acid transporting porin activity
N220_RS09785	COG0166	Belongs to the GPI family
N220_RS09815	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
N220_RS09820	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
N220_RS09835	COG0460	homoserine dehydrogenase
N220_RS09835	COG0527	aspartate kinase activity
N220_RS09840	COG0083	homoserine kinase activity
N220_RS09845	COG0215	cysteine-tRNA ligase activity
N220_RS09850	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
N220_RS09865	COG3383	formate dehydrogenase (NAD+) activity
N220_RS09865	COG0243	molybdopterin cofactor binding
N220_RS09870	COG3383	formate dehydrogenase (NAD+) activity
N220_RS09870	COG0243	molybdopterin cofactor binding
N220_RS09875	COG0437	4 iron, 4 sulfur cluster binding
N220_RS09880	COG2864	formate dehydrogenase
N220_RS09885	COG3058	Necessary for formate dehydrogenase activity
N220_RS09895	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
N220_RS09905	COG0778	Nitroreductase
N220_RS09910	COG4172	Belongs to the ABC transporter superfamily
N220_RS09915	COG0191	fructose-bisphosphate aldolase activity
N220_RS09920	COG0126	phosphoglycerate kinase activity
N220_RS09925	COG0733	neurotransmitter:sodium symporter activity
N220_RS09930	COG0338	D12 class N6 adenine-specific DNA methyltransferase
N220_RS09935	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
N220_RS09940	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
N220_RS09945	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
N220_RS09970	COG4796	Type ii and iii secretion system protein
N220_RS09975	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
N220_RS09980	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
N220_RS09985	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
N220_RS09990	COG1280	lysine exporter protein (LysE YggA)
N220_RS09995	COG0632	four-way junction helicase activity
N220_RS10000	COG2255	four-way junction helicase activity
N220_RS10005	COG4160	amino acid transport
N220_RS10010	COG4215	(ABC) transporter
N220_RS10015	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N220_RS10020	COG1126	abc transporter atp-binding protein
N220_RS10025	COG4232	protein-disulfide reductase activity
N220_RS10030	COG3101	peptidyl-lysine hydroxylation
N220_RS10035	COG1022	Amp-dependent synthetase and ligase
N220_RS10040	COG0251	oxidation-reduction process
N220_RS10050	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
N220_RS10055	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
N220_RS10060	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
N220_RS10065	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
N220_RS10075	COG0287	Prephenate dehydrogenase
N220_RS10075	COG1605	Chorismate mutase
N220_RS10080	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
N220_RS10085	COG0859	PFAM glycosyl transferase family 9
N220_RS10090	COG0469	pyruvate kinase activity
N220_RS10095	COG2062	phosphohistidine phosphatase, SixA
N220_RS10100	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
N220_RS10110	COG1629	transport
N220_RS10110	COG4771	TonB-dependent receptor
N220_RS10125	COG0346	lactoylglutathione lyase activity
N220_RS10140	COG2911	Protein conserved in bacteria
N220_RS10150	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
N220_RS10155	COG0617	tRNA 3'-terminal CCA addition
N220_RS10160	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
N220_RS10165	COG4143	(ABC) transporter
N220_RS10170	COG0402	S-adenosylhomocysteine deaminase activity
N220_RS10175	COG3753	Protein conserved in bacteria
N220_RS10185	COG0492	ferredoxin-NADP+ reductase activity
N220_RS10190	COG2376	Dihydroxyacetone kinase
N220_RS10195	COG1461	Dihydroxyacetone kinase
N220_RS10200	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
N220_RS10200	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
N220_RS10200	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
N220_RS10205	COG3118	belongs to the thioredoxin family
N220_RS10235	COG3115	cell septum assembly
N220_RS10255	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
N220_RS10265	COG0475	glutathione-regulated potassium exporter activity
N220_RS10265	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
N220_RS10275	COG4580	involved in the transport of maltose and maltodextrins
N220_RS10280	COG3842	ATPase activity
N220_RS10290	COG1175	transmembrane transport
N220_RS10295	COG3833	ABC-type maltose transport systems, permease component
N220_RS10300	COG0366	Alpha amylase catalytic
N220_RS10305	COG2909	trisaccharide binding
N220_RS10310	COG0058	SHG alpha-glucan phosphorylase activity
N220_RS10315	COG1640	4-alpha-glucanotransferase
N220_RS10325	COG2056	Na+-H+ antiporter family
N220_RS10330	COG0708	Exodeoxyribonuclease III
N220_RS10335	COG3117	lipopolysaccharide transmembrane transporter activity
N220_RS10340	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
N220_RS10345	COG1137	ATPase activity
N220_RS10350	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
N220_RS10360	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
N220_RS10375	COG2177	Part of the ABC transporter FtsEX involved in
N220_RS10380	COG2884	Cell division ATP-binding protein ftsE
N220_RS10385	COG0552	protein localization to endoplasmic reticulum
N220_RS10390	COG0742	ribosomal rna small subunit methyltransferase
N220_RS10395	COG3099	Belongs to the UPF0263 family
N220_RS10400	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
N220_RS10410	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
N220_RS10415	COG3326	Membrane
N220_RS10420	COG1027	Aspartate ammonia-lyase
N220_RS10425	COG0210	DNA helicase
N220_RS10430	COG3842	ATPase activity
N220_RS10435	COG1176	ABC-type spermidine putrescine transport system, permease component I
N220_RS10440	COG1177	transmembrane transport
N220_RS10445	COG0601	transmembrane transport
N220_RS10450	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
N220_RS10455	COG4172	Belongs to the ABC transporter superfamily
N220_RS10475	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
N220_RS10480	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
N220_RS10485	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
N220_RS10490	COG1629	transport
N220_RS10490	COG4206	TonB-dependent receptor
N220_RS10495	COG1629	transport
N220_RS10495	COG4206	TonB-dependent receptor
N220_RS10505	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
N220_RS10525	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
N220_RS10530	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
N220_RS10535	COG0483	inositol monophosphate 1-phosphatase activity
N220_RS10540	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
N220_RS10545	COG1966	Carbon starvation protein
N220_RS10550	COG0084	hydrolase, TatD family'
N220_RS10575	COG4591	ABC-type transport system involved in lipoprotein release permease component
N220_RS10580	COG1136	(ABC) transporter
N220_RS10585	COG4591	ABC-type transport system involved in lipoprotein release permease component
N220_RS10590	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
N220_RS10620	COG0512	Glutamine amidotransferase of anthranilate synthase
N220_RS10625	COG1322	Protein conserved in bacteria
N220_RS10625	COG1322	Protein conserved in bacteria
N220_RS10635	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
N220_RS10645	COG2137	regulation of response to DNA damage stimulus
N220_RS10655	COG0551	DNA topoisomerase type I activity
N220_RS10660	COG0009	L-threonylcarbamoyladenylate synthase
N220_RS10665	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
N220_RS10690	COG0210	DNA helicase
N220_RS10695	COG1090	epimerase
N220_RS10715	COG1666	GTP binding
N220_RS10720	COG0560	Phosphoserine phosphatase
N220_RS10730	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
N220_RS10735	COG2081	HI0933 family
N220_RS10740	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
N220_RS10745	COG2252	PERMEase
N220_RS10750	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
N220_RS10760	COG0716	FMN binding
N220_RS10765	COG0735	belongs to the Fur family
N220_RS10770	COG3008	intermembrane lipid transfer
N220_RS10775	COG1854	S-ribosylhomocysteine lyase activity
N220_RS10780	COG1132	(ABC) transporter
N220_RS10785	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
N220_RS10790	COG0592	DNA-directed DNA polymerase activity
N220_RS10795	COG2976	Protein conserved in bacteria
N220_RS10805	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
N220_RS10810	COG1426	Protein conserved in bacteria
N220_RS10815	COG0165	Argininosuccinate lyase
N220_RS10835	COG2991	Protein conserved in bacteria
N220_RS10840	COG1477	protein flavinylation
N220_RS10845	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
N220_RS10850	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
N220_RS10855	COG2871	sodium ion transport
N220_RS10860	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
N220_RS10865	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
N220_RS10870	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
N220_RS10875	COG1805	sodium ion transport
N220_RS10885	COG0316	Belongs to the HesB IscA family
N220_RS10885	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
N220_RS10895	COG0252	asparaginase activity
N220_RS10905	COG0583	DNA-binding transcription factor activity
N220_RS10910	COG1011	Hydrolase
N220_RS10915	COG0583	DNA-binding transcription factor activity
N220_RS10920	COG1162	GTPase activity
N220_RS10930	COG0537	adenosine 5'-monophosphoramidase activity
N220_RS10940	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
N220_RS10945	COG3108	Peptidase M15
N220_RS10950	COG2989	Protein conserved in bacteria
N220_RS10955	COG0793	Belongs to the peptidase S41A family
N220_RS10960	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
N220_RS10970	COG2814	Major facilitator Superfamily
N220_RS10975	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
N220_RS10985	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
N220_RS11015	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
N220_RS11020	COG0792	nuclease activity
N220_RS11025	COG3107	peptidoglycan biosynthetic process
N220_RS11040	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
N220_RS11045	COG1414	Transcriptional regulator
N220_RS11050	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
N220_RS11055	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
N220_RS11070	COG3068	Protein conserved in bacteria
N220_RS11085	COG1530	ribonuclease E activity
N220_RS11095	COG4977	sequence-specific DNA binding
N220_RS11095	COG1917	Cupin 2, conserved barrel domain protein
N220_RS11105	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
N220_RS11110	COG2824	Alkylphosphonate utilization operon protein PhnA
N220_RS11115	COG0557	exoribonuclease II activity
N220_RS11135	COG3116	cell division
N220_RS11140	COG0768	penicillin binding
N220_RS11145	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
N220_RS11150	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
N220_RS11155	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
N220_RS11160	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
N220_RS11165	COG0772	Belongs to the SEDS family
N220_RS11170	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
N220_RS11180	COG1181	Belongs to the D-alanine--D-alanine ligase family
N220_RS11190	COG0849	cell division
N220_RS11205	COG0497	DNA recombination
N220_RS11270	COG1652	LysM domain
N220_RS11275	COG2927	DNA polymerase III (CHI subunit)
N220_RS11280	COG2153	protein acetylation
N220_RS11290	COG4185	zeta toxin
N220_RS11300	COG0525	valine-tRNA ligase activity
N220_RS11310	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
N220_RS11315	COG1794	racemase activity, acting on amino acids and derivatives
N220_RS11325	COG0363	glucosamine-6-phosphate deaminase activity
N220_RS11330	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
N220_RS11335	COG1218	3'(2'),5'-bisphosphate nucleotidase
N220_RS11340	COG0494	nUDIX hydrolase
N220_RS11345	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
N220_RS11370	COG0107	imidazoleglycerol-phosphate synthase activity
N220_RS11385	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
N220_RS11400	COG0131	Imidazoleglycerol-phosphate dehydratase
N220_RS11400	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
N220_RS11425	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
N220_RS11430	COG0456	acetyltransferase
N220_RS11435	COG1217	gtp-binding protein TYPA
N220_RS11445	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
N220_RS11465	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
N220_RS11470	COG0582	viral genome integration into host DNA
N220_RS11495	COG3728	DNA packaging
N220_RS11505	COG1045	serine acetyltransferase
N220_RS11510	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
N220_RS11515	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
N220_RS11520	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
N220_RS11525	COG0544	peptidyl-prolyl cis-trans isomerase activity
N220_RS11535	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
N220_RS11540	COG0049	tRNA binding
N220_RS11545	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
N220_RS11550	COG0859	PFAM glycosyl transferase family 9
N220_RS11555	COG0859	PFAM glycosyl transferase family 9
N220_RS11565	COG3061	Opacity-associated protein A
N220_RS11565	COG3266	domain, Protein
N220_RS11570	COG1555	photosystem II stabilization
N220_RS11575	COG0688	phosphatidylethanolamine metabolic process
N220_RS11600	COG4974	Belongs to the 'phage' integrase family
N220_RS11615	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
N220_RS11615	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
N220_RS11620	COG3715	PTS system
N220_RS11625	COG3716	PTS system mannose fructose sorbose family IID component
N220_RS11645	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
N220_RS11650	COG1238	metal cluster binding
N220_RS11665	COG1388	LysM domain
N220_RS11665	COG4942	peptidase
N220_RS11675	COG2818	Glycosylase
N220_RS11685	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
N220_RS11695	COG0257	Belongs to the bacterial ribosomal protein bL36 family
N220_RS11700	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N220_RS11705	COG0765	amino acid transport
N220_RS11710	COG1126	abc transporter atp-binding protein
N220_RS11715	COG0762	integral membrane protein
N220_RS11720	COG3171	Protein conserved in bacteria
N220_RS11725	COG0220	tRNA (guanine-N7-)-methyltransferase activity
N220_RS11730	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
N220_RS11740	COG0805	protein transport
N220_RS11745	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
N220_RS11750	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
N220_RS11755	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
N220_RS11760	COG4804	nuclease activity
N220_RS11765	COG3165	ubiquinone biosynthetic process from chorismate
N220_RS11770	COG2226	methyltransferase
N220_RS11775	COG0598	Magnesium transport protein CorA
N220_RS11790	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
N220_RS11795	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
N220_RS11800	COG0783	Belongs to the Dps family
N220_RS11810	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
N220_RS11820	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
N220_RS11825	COG2259	Doxx family
N220_RS11830	COG1040	competence protein
N220_RS11835	COG0561	phosphatase activity
N220_RS11840	COG0697	spore germination
N220_RS11845	COG0697	spore germination
N220_RS11855	COG0261	This protein binds to 23S rRNA in the presence of protein L20
N220_RS11860	COG0142	geranyltranstransferase activity
N220_RS11865	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
N220_RS11870	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
N220_RS11880	COG1028	Short-chain dehydrogenase reductase Sdr
N220_RS11885	COG1114	Component of the transport system for branched-chain amino acids
N220_RS11895	COG1490	D-aminoacyl-tRNA deacylase activity
N220_RS11900	COG1295	ribonuclease BN
N220_RS11915	COG3041	Addiction module toxin RelE StbE family
N220_RS11920	COG3077	Addiction module antitoxin, RelB DinJ family
N220_RS11935	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
N220_RS11955	COG0347	Belongs to the P(II) protein family
N220_RS11975	COG0753	catalase activity
N220_RS11980	COG0425	Belongs to the sulfur carrier protein TusA family
N220_RS11985	COG2391	methyltransferase activity
N220_RS11995	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
N220_RS12000	COG1393	Belongs to the ArsC family
N220_RS12005	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
N220_RS12010	COG0564	pseudouridine synthase activity
N220_RS12015	COG0668	transmembrane transport
N220_RS12020	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
N220_RS12030	COG0431	NADPH-dependent FMN reductase
N220_RS12040	COG1902	pentaerythritol trinitrate reductase activity
N220_RS12045	COG0778	Nitroreductase
N220_RS12080	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
N220_RS12085	COG1064	alcohol dehydrogenase
N220_RS12090	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
N220_RS12110	COG0494	nUDIX hydrolase
N220_RS12115	COG0730	response to heat
N220_RS12125	COG0546	phosphoglycolate phosphatase activity
N220_RS12140	COG0180	Tryptophanyl-tRNA synthetase
N220_RS12145	COG0501	Belongs to the peptidase M48B family
N220_RS12150	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
N220_RS12170	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
N220_RS12175	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
N220_RS12180	COG0470	DNA polymerase III
N220_RS12195	COG0084	hydrolase, TatD family'
N220_RS12205	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
N220_RS12235	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
N220_RS12260	COG3133	Outer membrane lipoprotein
N220_RS12265	COG3102	Protein conserved in bacteria
N220_RS12270	COG0018	arginyl-trna synthetase
N220_RS12275	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
N220_RS12285	COG1138	Cytochrome C-type biogenesis protein
N220_RS12295	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
N220_RS12300	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
N220_RS12305	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
N220_RS12310	COG4133	protoheme IX ABC transporter activity
N220_RS12315	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
N220_RS12320	COG0747	negative chemotaxis
N220_RS12325	COG0601	transmembrane transport
N220_RS12330	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
N220_RS12335	COG0444	Belongs to the ABC transporter superfamily
N220_RS12340	COG4608	Belongs to the ABC transporter superfamily
N220_RS12345	COG1595	DNA-templated transcription, initiation
N220_RS12350	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
N220_RS12350	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
N220_RS12355	COG2801	Transposase and inactivated derivatives
N220_RS12360	COG0616	signal peptide processing
N220_RS12375	COG2801	Transposase and inactivated derivatives
N220_RS12420	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
N220_RS12435	COG0174	glutamine synthetase
N220_RS12450	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
N220_RS12460	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
N220_RS12485	COG0085	RNA polymerase activity
N220_RS12500	COG2168	tRNA wobble position uridine thiolation
N220_RS12510	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
N220_RS12515	COG2964	Protein conserved in bacteria
N220_RS12520	COG0545	Peptidyl-prolyl cis-trans isomerase
N220_RS12525	COG2900	Belongs to the SlyX family
N220_RS12540	COG3914	O-linked N-acetylglucosamine transferase SPINDLY family
N220_RS12550	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
N220_RS12555	COG1328	CTP reductase activity
N220_RS12570	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
N220_RS12580	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
N220_RS12590	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
N220_RS12595	COG1028	Short-chain dehydrogenase reductase Sdr
N220_RS12610	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
N220_RS12625	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
N220_RS12635	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
N220_RS12655	COG0758	DNA mediated transformation
N220_RS12670	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
N220_RS12675	COG1067	ATP-dependent peptidase activity
N220_RS12680	COG3120	sequence-specific DNA binding
N220_RS12690	COG0277	FAD linked oxidase domain protein
N220_RS12690	COG0247	lactate metabolic process
N220_RS12695	COG2050	protein possibly involved in aromatic compounds catabolism
N220_RS12710	COG0204	Acyl-transferase
N220_RS12720	COG0825	malonyl-CoA metabolic process
N220_RS12745	COG0235	Class ii aldolase
N220_RS12750	COG3623	hexulose-6-phosphate isomerase
N220_RS12770	COG0737	Belongs to the 5'-nucleotidase family
N220_RS12790	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
N220_RS12795	COG1929	Belongs to the glycerate kinase type-1 family
N220_RS12800	COG2610	gluconate transmembrane transporter activity
N220_RS12805	COG3835	regulator
N220_RS12825	COG0840	transmembrane signaling receptor activity
N220_RS12850	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
N220_RS12860	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
N220_RS12870	COG0089	rRNA binding
N220_RS12875	COG0088	Forms part of the polypeptide exit tunnel
N220_RS12880	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
N220_RS12885	COG0051	transcription antitermination factor activity, RNA binding
N220_RS12890	COG3070	regulator of competence-specific genes
N220_RS12905	COG0019	diaminopimelate decarboxylase activity
N220_RS12910	COG0625	glutathione transferase activity
N220_RS12920	COG2264	protein methyltransferase activity
N220_RS12955	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
N220_RS12960	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
N220_RS12965	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
N220_RS12970	COG1053	succinate dehydrogenase
N220_RS12975	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
N220_RS12980	COG2962	Rard protein
N220_RS12985	COG2223	nitrite transmembrane transporter activity
N220_RS12990	COG2223	nitrite transmembrane transporter activity
N220_RS12995	COG2223	nitrite transmembrane transporter activity
N220_RS13000	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
N220_RS13005	COG2020	methyltransferase activity
N220_RS13010	COG0728	peptidoglycan biosynthetic process
N220_RS13015	COG0268	Binds directly to 16S ribosomal RNA
N220_RS13020	COG1970	mechanosensitive ion channel activity
N220_RS13025	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
N220_RS13030	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
N220_RS13035	COG1739	Uncharacterized protein family UPF0029
N220_RS13045	COG1119	ATPase activity
N220_RS13055	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
N220_RS13060	COG2801	Transposase and inactivated derivatives
N220_RS13065	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
N220_RS13070	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
N220_RS13075	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
N220_RS13080	COG0321	lipoyl(octanoyl) transferase activity
N220_RS13085	COG2921	Belongs to the UPF0250 family
N220_RS13090	COG1686	Belongs to the peptidase S11 family
N220_RS13095	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
N220_RS13100	COG0772	Belongs to the SEDS family
N220_RS13105	COG0768	penicillin binding
N220_RS13115	COG0799	negative regulation of ribosome biogenesis
N220_RS13125	COG1312	Catalyzes the dehydration of D-mannonate
N220_RS13130	COG2186	Transcriptional regulator
N220_RS13135	COG1063	alcohol dehydrogenase
N220_RS13140	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
N220_RS13145	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
N220_RS13150	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
N220_RS13155	COG1028	Short-chain dehydrogenase reductase Sdr
N220_RS13160	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
N220_RS13165	COG0800	Aldolase
N220_RS13170	COG4783	chaperone-mediated protein folding
N220_RS13190	COG0545	Peptidyl-prolyl cis-trans isomerase
N220_RS13195	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
N220_RS13210	COG3676	manually curated
N220_RS13220	COG0037	tRNA processing
N220_RS13225	COG4974	Belongs to the 'phage' integrase family
N220_RS13275	COG3161	chorismate lyase activity
N220_RS13285	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
N220_RS13305	COG0442	prolyl-tRNA aminoacylation
N220_RS13325	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
N220_RS13335	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
N220_RS13340	COG1192	Involved in chromosome partitioning
N220_RS13355	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
N220_RS13360	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
N220_RS13410	COG3012	SEC-C Motif Domain Protein