locus-tag	class	description
HV559_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HV559_RS00010	COG0592	DNA-directed DNA polymerase activity
HV559_RS00020	COG2976	Protein conserved in bacteria
HV559_RS00030	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HV559_RS00035	COG1426	Protein conserved in bacteria
HV559_RS00040	COG0165	Argininosuccinate lyase
HV559_RS00050	COG2991	Protein conserved in bacteria
HV559_RS00055	COG1477	protein flavinylation
HV559_RS00060	COG2871	sodium ion transport
HV559_RS00065	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HV559_RS00070	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HV559_RS00075	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HV559_RS00080	COG1805	sodium ion transport
HV559_RS00090	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HV559_RS00090	COG0316	Belongs to the HesB IscA family
HV559_RS00110	COG0583	DNA-binding transcription factor activity
HV559_RS00115	COG1011	Hydrolase
HV559_RS00120	COG0583	DNA-binding transcription factor activity
HV559_RS00125	COG1162	GTPase activity
HV559_RS00135	COG0537	adenosine 5'-monophosphoramidase activity
HV559_RS00150	COG3068	Protein conserved in bacteria
HV559_RS00155	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HV559_RS00165	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
HV559_RS00175	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HV559_RS00180	COG1414	Transcriptional regulator
HV559_RS00185	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HV559_RS00195	COG3107	peptidoglycan biosynthetic process
HV559_RS00200	COG0792	nuclease activity
HV559_RS00205	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HV559_RS00235	COG2814	Major facilitator Superfamily
HV559_RS00245	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
HV559_RS00250	COG0793	Belongs to the peptidase S41A family
HV559_RS00255	COG2989	Protein conserved in bacteria
HV559_RS00260	COG3108	Peptidase M15
HV559_RS00265	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HV559_RS00305	COG0745	RESPONSE REGULATOR receiver
HV559_RS00310	COG2129	metallophosphoesterase
HV559_RS00315	COG3172	ATPase kinase involved in NAD metabolism
HV559_RS00320	COG0196	riboflavin kinase activity
HV559_RS00325	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HV559_RS00330	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HV559_RS00335	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HV559_RS00365	COG1476	TRANSCRIPTIONal
HV559_RS00370	COG4172	Belongs to the ABC transporter superfamily
HV559_RS00380	COG0601	transmembrane transport
HV559_RS00385	COG0747	negative chemotaxis
HV559_RS00405	COG1686	Belongs to the peptidase S11 family
HV559_RS00410	COG0193	aminoacyl-tRNA hydrolase activity
HV559_RS00425	COG1620	l-lactate permease
HV559_RS00430	COG0247	lactate metabolic process
HV559_RS00435	COG1139	Iron-sulfur cluster binding protein
HV559_RS00440	COG1556	Lactate utilization protein
HV559_RS00445	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HV559_RS00450	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HV559_RS00455	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HV559_RS00475	COG1720	tRNA m6t6A37 methyltransferase activity
HV559_RS00480	COG1575	Belongs to the MenA family. Type 1 subfamily
HV559_RS00525	COG0594	ribonuclease P activity
HV559_RS00530	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HV559_RS00540	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HV559_RS00545	COG1758	RNA polymerase activity
HV559_RS00555	COG1621	beta-fructofuranosidase activity
HV559_RS00560	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV559_RS00570	COG2190	(PTS) system
HV559_RS00575	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HV559_RS00580	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV559_RS00585	COG1178	ABC-type Fe3 transport system permease component
HV559_RS00590	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
HV559_RS00600	COG0024	Methionine aminopeptidase
HV559_RS00605	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HV559_RS00620	COG0805	protein transport
HV559_RS00625	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HV559_RS00630	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HV559_RS00635	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HV559_RS00645	COG2226	methyltransferase
HV559_RS00650	COG0598	Magnesium transport protein CorA
HV559_RS00660	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HV559_RS00670	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HV559_RS00675	COG1040	competence protein
HV559_RS00680	COG0561	phosphatase activity
HV559_RS00685	COG0697	spore germination
HV559_RS00695	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HV559_RS00700	COG0142	geranyltranstransferase activity
HV559_RS00705	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HV559_RS00710	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HV559_RS00720	COG1028	Short-chain dehydrogenase reductase Sdr
HV559_RS00725	COG1114	Component of the transport system for branched-chain amino acids
HV559_RS00740	COG1490	D-aminoacyl-tRNA deacylase activity
HV559_RS00745	COG1295	ribonuclease BN
HV559_RS00760	COG3041	Addiction module toxin RelE StbE family
HV559_RS00765	COG3077	Addiction module antitoxin, RelB DinJ family
HV559_RS00780	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HV559_RS00785	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV559_RS00860	COG3177	Filamentation induced by cAMP protein fic
HV559_RS00935	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HV559_RS00945	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HV559_RS00950	COG3005	denitrification pathway
HV559_RS00955	COG3043	anaerobic respiration
HV559_RS00960	COG0348	domain, Protein
HV559_RS00965	COG0437	4 iron, 4 sulfur cluster binding
HV559_RS00970	COG0243	molybdopterin cofactor binding
HV559_RS00975	COG3062	negative regulation of establishment of protein localization
HV559_RS00985	COG2249	NAD(P)H dehydrogenase (quinone) activity
HV559_RS00990	COG0076	glutamate decarboxylase activity
HV559_RS00995	COG1487	ribonuclease activity
HV559_RS01005	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HV559_RS01020	COG2003	Belongs to the UPF0758 family
HV559_RS01025	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HV559_RS01035	COG4804	nuclease activity
HV559_RS01045	COG1309	transcriptional regulator
HV559_RS01060	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HV559_RS01065	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HV559_RS01065	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HV559_RS01105	COG0174	glutamine synthetase
HV559_RS01110	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HV559_RS01130	COG0085	RNA polymerase activity
HV559_RS01165	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HV559_RS01175	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HV559_RS01185	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HV559_RS01205	COG3959	Transketolase, thiamine diphosphate binding domain
HV559_RS01210	COG3958	Transketolase
HV559_RS01215	COG0758	DNA mediated transformation
HV559_RS01235	COG1737	Transcriptional regulator
HV559_RS01240	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HV559_RS01255	COG3962	Belongs to the TPP enzyme family
HV559_RS01265	COG0673	inositol 2-dehydrogenase activity
HV559_RS01275	COG0673	inositol 2-dehydrogenase activity
HV559_RS01280	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV559_RS01285	COG1129	ABC transporter
HV559_RS01300	COG3718	enzyme involved in inositol metabolism
HV559_RS01315	COG5295	Hep Hag repeat protein
HV559_RS01315	COG5295	Hep Hag repeat protein
HV559_RS01340	COG1194	a g-specific adenine glycosylase
HV559_RS01345	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
HV559_RS01350	COG0741	lytic transglycosylase activity
HV559_RS01375	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HV559_RS01385	COG2168	tRNA wobble position uridine thiolation
HV559_RS01395	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HV559_RS01400	COG2964	Protein conserved in bacteria
HV559_RS01405	COG0545	Peptidyl-prolyl cis-trans isomerase
HV559_RS01410	COG2900	Belongs to the SlyX family
HV559_RS01425	COG1929	Belongs to the glycerate kinase type-1 family
HV559_RS01440	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HV559_RS01445	COG1509	lysine 2,3-aminomutase activity
HV559_RS01460	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HV559_RS01470	COG3700	Belongs to the class B bacterial acid phosphatase family
HV559_RS01490	COG3623	hexulose-6-phosphate isomerase
HV559_RS01495	COG0235	Class ii aldolase
HV559_RS01510	COG1349	DNA-binding transcription factor activity
HV559_RS01515	COG2084	Dehydrogenase
HV559_RS01520	COG3395	kinase activity
HV559_RS01525	COG0235	Class ii aldolase
HV559_RS01530	COG3622	Belongs to the hyi family
HV559_RS01535	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HV559_RS01540	COG2610	gluconate transmembrane transporter activity
HV559_RS01560	COG1126	abc transporter atp-binding protein
HV559_RS01570	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HV559_RS01575	COG1349	DNA-binding transcription factor activity
HV559_RS01580	COG0584	glycerophosphoryl diester phosphodiesterase
HV559_RS01585	COG2271	Major facilitator Superfamily
HV559_RS01605	COG4575	ribosome binding
HV559_RS01630	COG1129	ABC transporter
HV559_RS01640	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HV559_RS01645	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HV559_RS01650	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HV559_RS01655	COG2731	YhcH YjgK YiaL family protein
HV559_RS01660	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HV559_RS01665	COG0490	domain, Protein
HV559_RS01665	COG0471	metal ion transport
HV559_RS01670	COG3722	fumarate hydratase activity
HV559_RS01685	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HV559_RS01685	COG0517	IMP dehydrogenase activity
HV559_RS01690	COG2608	mercury ion transmembrane transporter activity
HV559_RS01700	COG1305	Transglutaminase-like
HV559_RS01705	COG0673	inositol 2-dehydrogenase activity
HV559_RS01715	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HV559_RS01725	COG0252	asparaginase activity
HV559_RS01735	COG1629	transport
HV559_RS01735	COG4206	TonB-dependent receptor
HV559_RS01755	COG1373	ATPase (AAA superfamily
HV559_RS01765	COG1349	DNA-binding transcription factor activity
HV559_RS01770	COG2407	Converts the aldose L-fucose into the corresponding ketose L-fuculose
HV559_RS01775	COG1070	Carbohydrate kinase
HV559_RS01780	COG4154	Belongs to the RbsD FucU family
HV559_RS01785	COG0235	Class ii aldolase
HV559_RS01790	COG0738	Major facilitator superfamily
HV559_RS01795	COG1454	alcohol dehydrogenase
HV559_RS01800	COG1012	belongs to the aldehyde dehydrogenase family
HV559_RS01805	COG0569	domain protein
HV559_RS01810	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HV559_RS01825	COG2358	TRAP transporter, solute receptor (TAXI family
HV559_RS01830	COG5295	Hep Hag repeat protein
HV559_RS01835	COG3276	selenocysteine insertion sequence binding
HV559_RS01850	COG1921	L-seryl-tRNASec selenium transferase activity
HV559_RS01875	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
HV559_RS01885	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HV559_RS01915	COG0716	FMN binding
HV559_RS01940	COG0442	prolyl-tRNA aminoacylation
HV559_RS01955	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HV559_RS01965	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HV559_RS01975	COG3012	SEC-C Motif Domain Protein
HV559_RS01980	COG0445	tRNA wobble uridine modification
HV559_RS02015	COG0357	Ribosomal RNA small subunit methyltransferase G
HV559_RS02040	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HV559_RS02045	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HV559_RS02075	COG2502	aspartate--ammonia ligase
HV559_RS02080	COG1522	sequence-specific DNA binding
HV559_RS02095	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
HV559_RS02100	COG3161	chorismate lyase activity
HV559_RS02105	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
HV559_RS02110	COG1518	maintenance of DNA repeat elements
HV559_RS02155	COG1337	RAMP superfamily
HV559_RS02210	COG4974	Belongs to the 'phage' integrase family
HV559_RS02215	COG0037	tRNA processing
HV559_RS02240	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HV559_RS02245	COG0545	Peptidyl-prolyl cis-trans isomerase
HV559_RS02285	COG1674	ftsk spoiiie
HV559_RS02290	COG0582	viral genome integration into host DNA
HV559_RS02305	COG0800	Aldolase
HV559_RS02310	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV559_RS02320	COG1028	Short-chain dehydrogenase reductase Sdr
HV559_RS02330	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HV559_RS02345	COG2186	Transcriptional regulator
HV559_RS02355	COG0799	negative regulation of ribosome biogenesis
HV559_RS02365	COG0768	penicillin binding
HV559_RS02370	COG0772	Belongs to the SEDS family
HV559_RS02375	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HV559_RS02380	COG1686	Belongs to the peptidase S11 family
HV559_RS02400	COG0321	lipoyl(octanoyl) transferase activity
HV559_RS02405	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HV559_RS02410	COG1119	ATPase activity
HV559_RS02420	COG1739	Uncharacterized protein family UPF0029
HV559_RS02425	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HV559_RS02440	COG0728	peptidoglycan biosynthetic process
HV559_RS02445	COG2020	methyltransferase activity
HV559_RS02450	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HV559_RS02455	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
HV559_RS02460	COG1053	succinate dehydrogenase
HV559_RS02465	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HV559_RS02470	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
HV559_RS02475	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
HV559_RS02520	COG2264	protein methyltransferase activity
HV559_RS02530	COG0625	glutathione transferase activity
HV559_RS02535	COG0019	diaminopimelate decarboxylase activity
HV559_RS02550	COG3070	regulator of competence-specific genes
HV559_RS02555	COG0051	transcription antitermination factor activity, RNA binding
HV559_RS02560	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HV559_RS02565	COG0088	Forms part of the polypeptide exit tunnel
HV559_RS02570	COG0089	rRNA binding
HV559_RS02580	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HV559_RS02585	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HV559_RS02590	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HV559_RS02605	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HV559_RS02635	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HV559_RS02640	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HV559_RS02650	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HV559_RS02660	COG0200	Binds to the 23S rRNA
HV559_RS02665	COG0201	protein transport
HV559_RS02675	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HV559_RS02685	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HV559_RS02690	COG0202	RNA polymerase activity
HV559_RS02700	COG0228	four-way junction DNA binding
HV559_RS02705	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HV559_RS02710	COG0336	Belongs to the RNA methyltransferase TrmD family
HV559_RS02720	COG2850	peptidyl-arginine hydroxylation
HV559_RS02725	COG0439	Biotin carboxylase
HV559_RS02730	COG0511	ligase activity, forming carbon-carbon bonds
HV559_RS02740	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HV559_RS02750	COG1876	peptidase activity
HV559_RS02755	COG0742	ribosomal rna small subunit methyltransferase
HV559_RS02760	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HV559_RS02765	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HV559_RS02775	COG0606	chelatase, subunit chli
HV559_RS02780	COG2267	carboxylic ester hydrolase activity
HV559_RS02805	COG3691	Protein conserved in bacteria
HV559_RS02815	COG4545	Glutaredoxin-related protein
HV559_RS02825	COG4804	nuclease activity
HV559_RS02830	COG2852	Protein conserved in bacteria
HV559_RS02860	COG2832	Protein of unknown function (DUF454)
HV559_RS02880	COG3085	chromosome segregation
HV559_RS02885	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HV559_RS02895	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HV559_RS02905	COG0521	Mo-molybdopterin cofactor biosynthetic process
HV559_RS02920	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HV559_RS02975	COG0204	Acyl-transferase
HV559_RS02990	COG2050	protein possibly involved in aromatic compounds catabolism
HV559_RS02995	COG0277	FAD linked oxidase domain protein
HV559_RS02995	COG0247	lactate metabolic process
HV559_RS03005	COG3120	sequence-specific DNA binding
HV559_RS03010	COG1067	ATP-dependent peptidase activity
HV559_RS03015	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HV559_RS03025	COG4795	General secretion pathway protein
HV559_RS03040	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HV559_RS03045	COG1025	Belongs to the peptidase M16 family
HV559_RS03050	COG0747	negative chemotaxis
HV559_RS03055	COG5295	Hep Hag repeat protein
HV559_RS03055	COG5295	Hep Hag repeat protein
HV559_RS03090	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HV559_RS03100	COG3545	Serine hydrolase
HV559_RS03120	COG0616	signal peptide processing
HV559_RS03135	COG4608	Belongs to the ABC transporter superfamily
HV559_RS03140	COG0444	Belongs to the ABC transporter superfamily
HV559_RS03145	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HV559_RS03150	COG0601	transmembrane transport
HV559_RS03155	COG0747	negative chemotaxis
HV559_RS03160	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HV559_RS03165	COG4133	protoheme IX ABC transporter activity
HV559_RS03170	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HV559_RS03175	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HV559_RS03180	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HV559_RS03190	COG1138	Cytochrome C-type biogenesis protein
HV559_RS03210	COG1476	TRANSCRIPTIONal
HV559_RS03230	COG0018	arginyl-trna synthetase
HV559_RS03235	COG3102	Protein conserved in bacteria
HV559_RS03240	COG3133	Outer membrane lipoprotein
HV559_RS03245	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HV559_RS03250	COG1793	dna ligase
HV559_RS03285	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HV559_RS03295	COG0084	hydrolase, TatD family'
HV559_RS03300	COG0470	DNA polymerase III
HV559_RS03305	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HV559_RS03310	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HV559_RS03330	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HV559_RS03335	COG0501	Belongs to the peptidase M48B family
HV559_RS03340	COG0180	Tryptophanyl-tRNA synthetase
HV559_RS03355	COG0730	response to heat
HV559_RS03360	COG0494	nUDIX hydrolase
HV559_RS03365	COG0431	NADPH-dependent FMN reductase
HV559_RS03370	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HV559_RS03375	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HV559_RS03380	COG0783	Belongs to the Dps family
HV559_RS03390	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HV559_RS03395	COG0668	transmembrane transport
HV559_RS03400	COG0564	pseudouridine synthase activity
HV559_RS03405	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HV559_RS03410	COG1393	Belongs to the ArsC family
HV559_RS03415	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HV559_RS03425	COG0753	catalase activity
HV559_RS03450	COG0347	Belongs to the P(II) protein family
HV559_RS03455	COG4145	pantothenate transmembrane transporter activity
HV559_RS03460	COG3924	membrane
HV559_RS03465	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
HV559_RS03470	COG2853	Lipoprotein
HV559_RS03475	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HV559_RS03500	COG1309	transcriptional regulator
HV559_RS03505	COG0583	DNA-binding transcription factor activity
HV559_RS03510	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HV559_RS03515	COG1803	Methylglyoxal synthase
HV559_RS03520	COG2995	paraquat-inducible protein a
HV559_RS03525	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HV559_RS03545	COG0416	fatty acid biosynthetic process
HV559_RS03555	COG1399	metal-binding, possibly nucleic acid-binding protein
HV559_RS03560	COG4137	Cytochrome C assembly protein
HV559_RS03565	COG4536	flavin adenine dinucleotide binding
HV559_RS03570	COG0733	neurotransmitter:sodium symporter activity
HV559_RS03580	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HV559_RS03585	COG0513	Belongs to the DEAD box helicase family
HV559_RS03590	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HV559_RS03595	COG3084	Protein conserved in bacteria
HV559_RS03610	COG0676	glucose-6-phosphate 1-epimerase activity
HV559_RS03615	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HV559_RS03620	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HV559_RS03625	COG3171	Protein conserved in bacteria
HV559_RS03630	COG0762	integral membrane protein
HV559_RS03635	COG1126	abc transporter atp-binding protein
HV559_RS03640	COG0765	amino acid transport
HV559_RS03645	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HV559_RS03650	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HV559_RS03660	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HV559_RS03670	COG2818	Glycosylase
HV559_RS03675	COG1388	LysM domain
HV559_RS03675	COG4942	peptidase
HV559_RS03690	COG1238	metal cluster binding
HV559_RS03695	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HV559_RS03700	COG0585	pseudouridine synthase activity
HV559_RS03720	COG3716	PTS system mannose fructose sorbose family IID component
HV559_RS03725	COG3715	PTS system
HV559_RS03730	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV559_RS03730	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV559_RS03740	COG4974	Belongs to the 'phage' integrase family
HV559_RS03745	COG0688	phosphatidylethanolamine metabolic process
HV559_RS03750	COG1555	photosystem II stabilization
HV559_RS03755	COG3266	domain, Protein
HV559_RS03755	COG3061	Opacity-associated protein A
HV559_RS03765	COG0859	PFAM glycosyl transferase family 9
HV559_RS03770	COG0859	PFAM glycosyl transferase family 9
HV559_RS03780	COG0049	tRNA binding
HV559_RS03795	COG0544	peptidyl-prolyl cis-trans isomerase activity
HV559_RS03800	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HV559_RS03805	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
HV559_RS03815	COG1045	serine acetyltransferase
HV559_RS03830	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HV559_RS03835	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HV559_RS03845	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HV559_RS03860	COG0456	acetyltransferase
HV559_RS03865	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
HV559_RS03890	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HV559_RS03890	COG0131	Imidazoleglycerol-phosphate dehydratase
HV559_RS03900	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HV559_RS03920	COG0107	imidazoleglycerol-phosphate synthase activity
HV559_RS03925	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HV559_RS03935	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HV559_RS03940	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HV559_RS03945	COG0494	nUDIX hydrolase
HV559_RS03950	COG1218	3'(2'),5'-bisphosphate nucleotidase
HV559_RS03955	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HV559_RS03960	COG0363	glucosamine-6-phosphate deaminase activity
HV559_RS03970	COG1794	racemase activity, acting on amino acids and derivatives
HV559_RS03975	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HV559_RS03985	COG0525	valine-tRNA ligase activity
HV559_RS03995	COG4185	zeta toxin
HV559_RS04010	COG2153	protein acetylation
HV559_RS04015	COG2927	DNA polymerase III (CHI subunit)
HV559_RS04020	COG1652	LysM domain
HV559_RS04030	COG1530	ribonuclease E activity
HV559_RS04040	COG1917	Cupin 2, conserved barrel domain protein
HV559_RS04040	COG4977	sequence-specific DNA binding
HV559_RS04050	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
HV559_RS04060	COG2824	Alkylphosphonate utilization operon protein PhnA
HV559_RS04065	COG0557	exoribonuclease II activity
HV559_RS04080	COG0275	rRNA processing
HV559_RS04085	COG3116	cell division
HV559_RS04090	COG0768	penicillin binding
HV559_RS04095	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HV559_RS04105	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HV559_RS04110	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HV559_RS04115	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HV559_RS04120	COG0772	Belongs to the SEDS family
HV559_RS04125	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HV559_RS04135	COG1181	Belongs to the D-alanine--D-alanine ligase family
HV559_RS04145	COG0849	cell division
HV559_RS04150	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HV559_RS04155	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HV559_RS04160	COG0497	DNA recombination
HV559_RS04205	COG1561	YicC-like family, N-terminal region
HV559_RS04210	COG0354	folic acid binding
HV559_RS04215	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HV559_RS04225	COG1129	ABC transporter
HV559_RS04230	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV559_RS04235	COG1879	ABC-type sugar transport system periplasmic component
HV559_RS04240	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV559_RS04245	COG1609	Transcriptional regulator
HV559_RS04250	COG2197	response regulator
HV559_RS04260	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HV559_RS04270	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HV559_RS04295	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HV559_RS04330	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
HV559_RS04340	COG0006	proline dipeptidase activity
HV559_RS04345	COG3030	protein affecting phage T7 exclusion by the F plasmid
HV559_RS04360	COG2816	NAD+ diphosphatase activity
HV559_RS04375	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HV559_RS04380	COG5413	integral membrane protein
HV559_RS04400	COG0308	aminopeptidase N
HV559_RS04405	COG0748	coenzyme F420 binding
HV559_RS04410	COG4771	TonB-dependent receptor
HV559_RS04410	COG1629	transport
HV559_RS04420	COG0814	amino acid
HV559_RS04425	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HV559_RS04465	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HV559_RS04470	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HV559_RS04475	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HV559_RS04480	COG1121	(ABC) transporter
HV559_RS04495	COG3063	Type IV pilus biogenesis stability protein PilW
HV559_RS04500	COG2183	response to ionizing radiation
HV559_RS04505	COG0300	oxidoreductase activity
HV559_RS04510	COG0778	Nitroreductase
HV559_RS04515	COG0616	signal peptide processing
HV559_RS04520	COG0352	thiamine-phosphate diphosphorylase activity
HV559_RS04530	COG0477	Major facilitator Superfamily
HV559_RS04540	COG3978	acetolactate synthase activity
HV559_RS04555	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
HV559_RS04560	COG0437	4 iron, 4 sulfur cluster binding
HV559_RS04565	COG3301	Polysulphide reductase, NrfD
HV559_RS04570	COG1138	Cytochrome C-type biogenesis protein
HV559_RS04580	COG3088	subunit of a heme lyase
HV559_RS04580	COG4235	cytochrome complex assembly
HV559_RS04585	COG4235	cytochrome complex assembly
HV559_RS04600	COG0789	Transcriptional regulator
HV559_RS04610	COG0583	DNA-binding transcription factor activity
HV559_RS04615	COG0659	secondary active sulfate transmembrane transporter activity
HV559_RS04625	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HV559_RS04630	COG1127	ABC transporter
HV559_RS04635	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HV559_RS04640	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HV559_RS04645	COG2854	intermembrane phospholipid transfer
HV559_RS04650	COG3113	response to antibiotic
HV559_RS04655	COG5007	Belongs to the BolA IbaG family
HV559_RS04660	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HV559_RS04665	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HV559_RS04675	COG0217	transcriptional regulatory protein
HV559_RS04680	COG0494	nUDIX hydrolase
HV559_RS04700	COG2431	L-lysine efflux transmembrane transporter activity
HV559_RS04705	COG0501	Belongs to the peptidase M48B family
HV559_RS04710	COG1238	metal cluster binding
HV559_RS04715	COG2116	formate transmembrane transporter activity
HV559_RS04720	COG1882	Formate acetyltransferase
HV559_RS04730	COG3676	manually curated
HV559_RS04755	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HV559_RS04760	COG0339	signal peptide processing
HV559_RS04765	COG0747	negative chemotaxis
HV559_RS04770	COG0077	Prephenate dehydratase
HV559_RS04770	COG1605	Chorismate mutase
HV559_RS04780	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HV559_RS04790	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HV559_RS04815	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HV559_RS04820	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HV559_RS04830	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HV559_RS04840	COG1966	Carbon starvation protein
HV559_RS04845	COG0084	hydrolase, TatD family'
HV559_RS04850	COG4285	Biotin-protein ligase, N terminal
HV559_RS04860	COG0477	Major facilitator Superfamily
HV559_RS04870	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
HV559_RS04890	COG3118	belongs to the thioredoxin family
HV559_RS04895	COG0492	ferredoxin-NADP+ reductase activity
HV559_RS04910	COG1663	tetraacyldisaccharide 4'-kinase activity
HV559_RS04920	COG3152	Membrane
HV559_RS04930	COG3177	Filamentation induced by cAMP protein fic
HV559_RS04935	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HV559_RS04940	COG0740	serine-type endopeptidase activity
HV559_RS04945	COG2166	iron-sulfur cluster assembly
HV559_RS04955	COG2226	methyltransferase
HV559_RS04970	COG0512	Glutamine amidotransferase of anthranilate synthase
HV559_RS04975	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HV559_RS04980	COG0009	L-threonylcarbamoyladenylate synthase
HV559_RS04990	COG0471	metal ion transport
HV559_RS04990	COG3273	potassium ion transport
HV559_RS04995	COG4591	ABC-type transport system involved in lipoprotein release permease component
HV559_RS05000	COG1136	(ABC) transporter
HV559_RS05005	COG4591	ABC-type transport system involved in lipoprotein release permease component
HV559_RS05035	COG0512	Glutamine amidotransferase of anthranilate synthase
HV559_RS05040	COG1322	Protein conserved in bacteria
HV559_RS05050	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HV559_RS05060	COG2137	regulation of response to DNA damage stimulus
HV559_RS05070	COG0551	DNA topoisomerase type I activity
HV559_RS05080	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HV559_RS05105	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HV559_RS05120	COG4589	Belongs to the CDS family
HV559_RS05125	COG2255	four-way junction helicase activity
HV559_RS05135	COG1280	lysine exporter protein (LysE YggA)
HV559_RS05140	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HV559_RS05145	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HV559_RS05150	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HV559_RS05155	COG4796	Type ii and iii secretion system protein
HV559_RS05180	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HV559_RS05185	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HV559_RS05190	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HV559_RS05195	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HV559_RS05200	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HV559_RS05205	COG0583	DNA-binding transcription factor activity
HV559_RS05210	COG2177	Part of the ABC transporter FtsEX involved in
HV559_RS05215	COG2884	Cell division ATP-binding protein ftsE
HV559_RS05220	COG0552	protein localization to endoplasmic reticulum
HV559_RS05225	COG0742	ribosomal rna small subunit methyltransferase
HV559_RS05230	COG3099	Belongs to the UPF0263 family
HV559_RS05235	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HV559_RS05245	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HV559_RS05250	COG4172	Belongs to the ABC transporter superfamily
HV559_RS05255	COG0126	phosphoglycerate kinase activity
HV559_RS05260	COG0191	fructose-bisphosphate aldolase activity
HV559_RS05270	COG1177	transmembrane transport
HV559_RS05275	COG1176	ABC-type spermidine putrescine transport system, permease component I
HV559_RS05280	COG3842	ATPase activity
HV559_RS05285	COG0210	DNA helicase
HV559_RS05290	COG0778	Nitroreductase
HV559_RS05295	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HV559_RS05305	COG3058	Necessary for formate dehydrogenase activity
HV559_RS05310	COG2864	formate dehydrogenase
HV559_RS05315	COG0437	4 iron, 4 sulfur cluster binding
HV559_RS05335	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HV559_RS05340	COG0215	cysteine-tRNA ligase activity
HV559_RS05345	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HV559_RS05370	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HV559_RS05380	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV559_RS05385	COG1137	ATPase activity
HV559_RS05390	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HV559_RS05395	COG3117	lipopolysaccharide transmembrane transporter activity
HV559_RS05400	COG0708	Exodeoxyribonuclease III
HV559_RS05405	COG2056	Na+-H+ antiporter family
HV559_RS05410	COG1640	4-alpha-glucanotransferase
HV559_RS05415	COG0058	SHG alpha-glucan phosphorylase activity
HV559_RS05420	COG2909	trisaccharide binding
HV559_RS05425	COG3833	ABC-type maltose transport systems, permease component
HV559_RS05430	COG1175	transmembrane transport
HV559_RS05435	COG2182	Extracellular solute-binding protein
HV559_RS05440	COG3842	ATPase activity
HV559_RS05445	COG4580	involved in the transport of maltose and maltodextrins
HV559_RS05460	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HV559_RS05470	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HV559_RS05510	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HV559_RS05515	COG1611	Belongs to the LOG family
HV559_RS05520	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HV559_RS05525	COG0795	lipopolysaccharide-transporting ATPase activity
HV559_RS05530	COG0795	lipopolysaccharide-transporting ATPase activity
HV559_RS05550	COG1519	Transferase
HV559_RS05560	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HV559_RS05565	COG0802	atpase or kinase
HV559_RS05570	COG0860	N-Acetylmuramoyl-L-alanine amidase
HV559_RS05570	COG1388	LysM domain
HV559_RS05580	COG0531	amino acid
HV559_RS05590	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV559_RS05595	COG0842	Transport permease protein
HV559_RS05595	COG1129	ABC transporter
HV559_RS05600	COG0842	Transport permease protein
HV559_RS05610	COG1012	belongs to the aldehyde dehydrogenase family
HV559_RS05610	COG1454	alcohol dehydrogenase
HV559_RS05615	COG0181	hydroxymethylbilane synthase activity
HV559_RS05625	COG2959	enzyme of heme biosynthesis
HV559_RS05630	COG3071	HemY protein
HV559_RS05635	COG2354	Protein conserved in bacteria
HV559_RS05640	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HV559_RS05645	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HV559_RS05650	COG2095	MarC family integral membrane protein
HV559_RS05655	COG4166	transmembrane transport
HV559_RS05660	COG0489	protein tyrosine kinase activity
HV559_RS05670	COG0302	gtp cyclohydrolase
HV559_RS05680	COG2217	Heavy metal translocating P-type atpase
HV559_RS05685	COG2608	mercury ion transmembrane transporter activity
HV559_RS05695	COG0789	Transcriptional regulator
HV559_RS05710	COG0187	DNA topoisomerase II activity
HV559_RS05715	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HV559_RS05720	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HV559_RS05725	COG0295	cytidine deaminase activity
HV559_RS05730	COG0542	response to heat
HV559_RS05735	COG0129	dihydroxy-acid dehydratase activity
HV559_RS05740	COG2914	Belongs to the UPF0125 (RnfH) family
HV559_RS05745	COG2867	negative regulation of translational initiation
HV559_RS05750	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HV559_RS05755	COG4149	molybdate abc transporter
HV559_RS05760	COG0725	ABC transporter, periplasmic molybdate-binding protein
HV559_RS05765	COG0842	Transport permease protein
HV559_RS05770	COG1131	(ABC) transporter
HV559_RS05775	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HV559_RS05780	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HV559_RS05785	COG2920	part of a sulfur-relay system
HV559_RS05790	COG0670	Belongs to the BI1 family
HV559_RS05795	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HV559_RS05825	COG3676	manually curated
HV559_RS05870	COG3676	manually curated
HV559_RS05890	COG1252	NADH dehydrogenase
HV559_RS05895	COG2252	PERMEase
HV559_RS05900	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HV559_RS05905	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HV559_RS05910	COG1862	Preprotein translocase
HV559_RS05915	COG1408	metallophosphoesterase
HV559_RS05925	COG0561	phosphatase activity
HV559_RS05935	COG1595	DNA-templated transcription, initiation
HV559_RS05940	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
HV559_RS05950	COG3086	response to oxidative stress
HV559_RS05955	COG0318	PFAM AMP-dependent synthetase and ligase
HV559_RS05960	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HV559_RS05965	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HV559_RS05970	COG4533	DNA binding
HV559_RS05980	COG0444	Belongs to the ABC transporter superfamily
HV559_RS05985	COG4608	Belongs to the ABC transporter superfamily
HV559_RS05990	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HV559_RS06005	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HV559_RS06015	COG1160	GTP binding
HV559_RS06020	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HV559_RS06020	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HV559_RS06025	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HV559_RS06030	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HV559_RS06035	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HV559_RS06040	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HV559_RS06045	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HV559_RS06050	COG2194	sulfuric ester hydrolase activity
HV559_RS06055	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HV559_RS06055	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HV559_RS06060	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HV559_RS06065	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HV559_RS06075	COG2840	Smr protein MutS2
HV559_RS06085	COG0697	spore germination
HV559_RS06095	COG2198	Histidine kinase
HV559_RS06095	COG5002	protein histidine kinase activity
HV559_RS06095	COG0784	Response regulator, receiver
HV559_RS06100	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HV559_RS06105	COG1959	2 iron, 2 sulfur cluster binding
HV559_RS06115	COG0822	iron-sulfur transferase activity
HV559_RS06125	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HV559_RS06145	COG0633	Ferredoxin
HV559_RS06150	COG2975	iron-sulfur cluster assembly
HV559_RS06155	COG0617	tRNA 3'-terminal CCA addition
HV559_RS06160	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HV559_RS06165	COG0730	response to heat
HV559_RS06170	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HV559_RS06175	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HV559_RS06185	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HV559_RS06190	COG4969	Belongs to the N-Me-Phe pilin family
HV559_RS06195	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HV559_RS06200	COG1459	type II secretion system
HV559_RS06210	COG0237	dephospho-CoA kinase activity
HV559_RS06215	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
HV559_RS06220	COG1466	dna polymerase III delta subunit
HV559_RS06225	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
HV559_RS06230	COG0495	leucyl-tRNA aminoacylation
HV559_RS06275	COG5005	Phage virion morphogenesis
HV559_RS06385	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HV559_RS06390	COG3106	COG3106 Predicted ATPase
HV559_RS06395	COG3025	triphosphatase activity
HV559_RS06400	COG3140	Belongs to the UPF0181 family
HV559_RS06405	COG0564	pseudouridine synthase activity
HV559_RS06410	COG3098	single-species biofilm formation
HV559_RS06415	COG0135	phosphoribosylanthranilate isomerase activity
HV559_RS06415	COG0134	indole-3-glycerol-phosphate synthase activity
HV559_RS06420	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HV559_RS06420	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HV559_RS06425	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HV559_RS06430	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HV559_RS06435	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HV559_RS06450	COG0750	zinc metalloprotease
HV559_RS06455	COG0575	Belongs to the CDS family
HV559_RS06460	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HV559_RS06475	COG0581	inorganic phosphate transmembrane transporter activity
HV559_RS06485	COG0745	RESPONSE REGULATOR receiver
HV559_RS06490	COG5002	protein histidine kinase activity
HV559_RS06495	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HV559_RS06520	COG1022	Amp-dependent synthetase and ligase
HV559_RS06545	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HV559_RS06555	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HV559_RS06560	COG0590	tRNA wobble adenosine to inosine editing
HV559_RS06565	COG0513	Belongs to the DEAD box helicase family
HV559_RS06570	COG4785	May be involved in cell division
HV559_RS06580	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HV559_RS06600	COG2337	Toxic component of a toxin-antitoxin (TA) module
HV559_RS06605	COG2336	PFAM SpoVT AbrB
HV559_RS06640	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV559_RS06645	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV559_RS06650	COG1129	ABC transporter
HV559_RS06670	COG1275	C4-dicarboxylate transporter malic acid transport protein
HV559_RS06675	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
HV559_RS06685	COG0542	response to heat
HV559_RS06690	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
HV559_RS06695	COG3083	sulfuric ester hydrolase activity
HV559_RS06705	COG1309	transcriptional regulator
HV559_RS06710	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV559_RS06715	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HV559_RS06730	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HV559_RS06735	COG0387	Pfam Sodium calcium exchanger
HV559_RS06740	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HV559_RS06745	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HV559_RS06760	COG4991	sh3 domain protein
HV559_RS06765	COG0306	phosphate transporter
HV559_RS06770	COG1392	Phosphate transport regulator
HV559_RS06775	COG0305	Participates in initiation and elongation during chromosome replication
HV559_RS06785	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HV559_RS06800	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HV559_RS06805	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
HV559_RS06810	COG1823	symporter activity
HV559_RS06815	COG0778	Nitroreductase
HV559_RS06820	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HV559_RS06825	COG0072	phenylalanine-tRNA ligase activity
HV559_RS06835	COG0791	NLP P60 protein
HV559_RS06840	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HV559_RS06850	COG0539	negative regulation of cytoplasmic translation
HV559_RS06860	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
HV559_RS06865	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HV559_RS06870	COG0284	orotidine-5'-phosphate decarboxylase activity
HV559_RS06875	COG0023	Translation Initiation Factor
HV559_RS06880	COG0737	Belongs to the 5'-nucleotidase family
HV559_RS06885	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HV559_RS06890	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
HV559_RS06895	COG0658	competence protein
HV559_RS06895	COG2333	competence protein COMEC
HV559_RS06905	COG3683	transport system, periplasmic component
HV559_RS06910	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
HV559_RS06915	COG1115	amino acid carrier protein
HV559_RS06935	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HV559_RS06940	COG0045	succinate-CoA ligase (ADP-forming) activity
HV559_RS06945	COG0508	dehydrogenase complex catalyzes the overall conversion of
HV559_RS06950	COG0567	Dehydrogenase, E1 component
HV559_RS06955	COG1121	(ABC) transporter
HV559_RS06960	COG0739	heme binding
HV559_RS06965	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HV559_RS06975	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HV559_RS06985	COG0561	phosphatase activity
HV559_RS06990	COG3850	Histidine kinase
HV559_RS07000	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HV559_RS07005	COG0393	Putative heavy-metal-binding
HV559_RS07010	COG2983	Belongs to the UPF0260 family
HV559_RS07015	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HV559_RS07020	COG3283	Transcriptional regulator of aromatic amino acids metabolism
HV559_RS07025	COG4166	transmembrane transport
HV559_RS07030	COG4168	peptide transport system, permease
HV559_RS07035	COG4171	peptide transport system, permease
HV559_RS07040	COG4172	Belongs to the ABC transporter superfamily
HV559_RS07045	COG5645	(Lipo)protein
HV559_RS07060	COG3021	interspecies interaction between organisms
HV559_RS07070	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HV559_RS07085	COG0251	oxidation-reduction process
HV559_RS07090	COG3081	Nucleoid-associated protein
HV559_RS07095	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HV559_RS07115	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HV559_RS07120	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HV559_RS07135	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HV559_RS07145	COG3036	rescue of stalled ribosome
HV559_RS07150	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HV559_RS07155	COG1940	carbohydrate kinase activity
HV559_RS07155	COG1846	Transcriptional regulator
HV559_RS07160	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HV559_RS07165	COG1522	sequence-specific DNA binding
HV559_RS07170	COG1674	ftsk spoiiie
HV559_RS07175	COG2321	neutral zinc metallopeptidase
HV559_RS07180	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HV559_RS07185	COG1214	PFAM Peptidase M22, glycoprotease
HV559_RS07190	COG1435	thymidine kinase activity
HV559_RS07195	COG3074	FtsZ-dependent cytokinesis
HV559_RS07200	COG1494	fructose-1,6-bisphosphatase
HV559_RS07210	COG0006	proline dipeptidase activity
HV559_RS07220	COG0440	acetolactate synthase activity
HV559_RS07225	COG0028	Belongs to the TPP enzyme family
HV559_RS07230	COG0288	reversible hydration of carbon dioxide
HV559_RS07235	COG0857	belongs to the CobB CobQ family
HV559_RS07235	COG0280	phosphate acetyltransferase
HV559_RS07245	COG0737	Belongs to the 5'-nucleotidase family
HV559_RS07260	COG0626	cystathionine gamma-synthase activity
HV559_RS07275	COG2363	Small membrane protein
HV559_RS07280	COG0243	molybdopterin cofactor binding
HV559_RS07290	COG0538	isocitrate dehydrogenase activity
HV559_RS07300	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HV559_RS07315	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HV559_RS07320	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HV559_RS07330	COG0589	response to stress
HV559_RS07340	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HV559_RS07350	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HV559_RS07360	COG0586	Pfam SNARE associated Golgi protein
HV559_RS07370	COG2226	methyltransferase
HV559_RS07375	COG0596	Alpha beta hydrolase
HV559_RS07385	COG0318	PFAM AMP-dependent synthetase and ligase
HV559_RS07390	COG3264	Mechanosensitive ion channel
HV559_RS07390	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
HV559_RS07400	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
HV559_RS07410	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HV559_RS07465	COG2176	DNA-directed DNA polymerase activity
HV559_RS07480	COG1802	Transcriptional regulator
HV559_RS07480	COG4626	Terminase
HV559_RS07530	COG4409	exo-alpha-(2->6)-sialidase activity
HV559_RS07535	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HV559_RS07540	COG0312	modulator of DNA gyrase
HV559_RS07545	COG3028	Belongs to the UPF0307 family
HV559_RS07550	COG3094	Invasion gene expression up-regulator, SirB
HV559_RS07560	COG3787	Belongs to the UPF0306 family
HV559_RS07570	COG3945	hemerythrin HHE cation binding domain
HV559_RS07585	COG1278	Cold shock
HV559_RS07590	COG1737	Transcriptional regulator
HV559_RS07595	COG2731	YhcH YjgK YiaL family protein
HV559_RS07600	COG0248	Ppx GppA phosphatase
HV559_RS07605	COG2926	Belongs to the UPF0265 family
HV559_RS07610	COG2190	(PTS) system
HV559_RS07610	COG1263	PTS System
HV559_RS07610	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV559_RS07615	COG0527	aspartate kinase activity
HV559_RS07630	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HV559_RS07635	COG3105	Protein conserved in bacteria
HV559_RS07650	COG0243	molybdopterin cofactor binding
HV559_RS07655	COG3005	denitrification pathway
HV559_RS07660	COG2909	trisaccharide binding
HV559_RS07670	COG0315	cyclic pyranopterin monophosphate synthase activity
HV559_RS07675	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HV559_RS07680	COG0314	molybdopterin synthase activity
HV559_RS07685	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HV559_RS07700	COG1444	tRNA N-acetyltransferase activity
HV559_RS07705	COG1448	Aminotransferase
HV559_RS07710	COG0285	dihydrofolate synthase activity
HV559_RS07720	COG3956	TIGRFAM MazG family protein
HV559_RS07725	COG0745	RESPONSE REGULATOR receiver
HV559_RS07730	COG2205	protein histidine kinase activity
HV559_RS07735	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HV559_RS07740	COG0697	spore germination
HV559_RS07745	COG0084	hydrolase, TatD family'
HV559_RS07750	COG0556	nucleotide-excision repair
HV559_RS07760	COG2837	iron assimilation
HV559_RS07765	COG0613	PHP domain protein
HV559_RS07775	COG2925	Exonuclease
HV559_RS07780	COG0017	Asparaginyl-tRNA synthetase
HV559_RS07785	COG1509	lysine 2,3-aminomutase activity
HV559_RS07795	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HV559_RS07800	COG2969	positive regulation of protein catabolic process
HV559_RS07805	COG0625	glutathione transferase activity
HV559_RS07810	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HV559_RS07815	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HV559_RS07885	COG1724	mRNA binding
HV559_RS07890	COG1598	PFAM Uncharacterised protein family UPF0150
HV559_RS07950	COG1783	phage Terminase large subunit
HV559_RS07955	COG3728	DNA packaging
HV559_RS08015	COG3549	Plasmid maintenance system killer
HV559_RS08020	COG3093	addiction module antidote protein HigA
HV559_RS08025	COG3617	BRO family, N-terminal domain
HV559_RS08040	COG0305	Participates in initiation and elongation during chromosome replication
HV559_RS08095	COG3617	BRO family, N-terminal domain
HV559_RS08200	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HV559_RS08215	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HV559_RS08225	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HV559_RS08230	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HV559_RS08230	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HV559_RS08235	COG5339	Protein conserved in bacteria
HV559_RS08245	COG0133	tryptophan synthase activity
HV559_RS08250	COG4221	oxidoreductase activity
HV559_RS08255	COG1757	Na H antiporter
HV559_RS08260	COG2916	Histone family protein nucleoid-structuring protein H-NS
HV559_RS08265	COG0788	formyltetrahydrofolate deformylase activity
HV559_RS08270	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HV559_RS08275	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HV559_RS08280	COG1530	ribonuclease E activity
HV559_RS08295	COG0500	methyltransferase
HV559_RS08300	COG1944	ATP diphosphatase activity
HV559_RS08330	COG1518	maintenance of DNA repeat elements
HV559_RS08350	COG0187	DNA topoisomerase II activity
HV559_RS08355	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HV559_RS08360	COG1349	DNA-binding transcription factor activity
HV559_RS08365	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HV559_RS08370	COG2915	High frequency lysogenization protein hflD homolog
HV559_RS08375	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HV559_RS08380	COG4988	ABC transporter
HV559_RS08385	COG2911	Protein conserved in bacteria
HV559_RS08390	COG0729	surface antigen
HV559_RS08400	COG4942	peptidase
HV559_RS08410	COG0233	cytoplasmic translational termination
HV559_RS08415	COG0528	UMP kinase activity
HV559_RS08430	COG1840	ABC-type Fe3 transport system, periplasmic component
HV559_RS08440	COG3842	ATPase activity
HV559_RS08445	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HV559_RS08450	COG0433	COG0433 Predicted ATPase
HV559_RS08455	COG0513	Belongs to the DEAD box helicase family
HV559_RS08465	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HV559_RS08475	COG0681	Belongs to the peptidase S26 family
HV559_RS08480	COG0481	GTPase activity
HV559_RS08485	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HV559_RS08515	COG2259	Doxx family
HV559_RS08530	COG3219	Protein conserved in bacteria
HV559_RS08535	COG1595	DNA-templated transcription, initiation
HV559_RS08550	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HV559_RS08555	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HV559_RS08565	COG1620	l-lactate permease
HV559_RS08570	COG0549	Belongs to the carbamate kinase family
HV559_RS08575	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HV559_RS08580	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HV559_RS08585	COG3257	ureidoglycine aminohydrolase activity
HV559_RS08595	COG1953	Uracil, thiamine, allantoin
HV559_RS08625	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HV559_RS08630	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HV559_RS08635	COG1286	toxin biosynthetic process
HV559_RS08640	COG0328	RNA-DNA hybrid ribonuclease activity
HV559_RS08650	COG0739	heme binding
HV559_RS08660	COG3738	Protein conserved in bacteria
HV559_RS08665	COG0859	PFAM glycosyl transferase family 9
HV559_RS08670	COG0463	Glycosyl transferase, family 2
HV559_RS08675	COG1534	Rna-binding protein
HV559_RS08680	COG0671	phosphoesterase, PA-phosphatase related
HV559_RS08690	COG1368	sulfuric ester hydrolase activity
HV559_RS08695	COG3217	Mosc domain protein beta barrel domain protein
HV559_RS08695	COG0633	Ferredoxin
HV559_RS08700	COG1722	exodeoxyribonuclease VII activity
HV559_RS08705	COG0142	geranyltranstransferase activity
HV559_RS08710	COG0121	glutamine amidotransferase
HV559_RS08715	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HV559_RS08720	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HV559_RS08725	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HV559_RS08730	COG1792	Involved in formation and maintenance of cell shape
HV559_RS08735	COG1077	Cell shape determining protein MreB Mrl
HV559_RS08745	COG0572	uridine kinase
HV559_RS08755	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HV559_RS08760	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HV559_RS08765	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
HV559_RS08770	COG1704	LemA family
HV559_RS08785	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HV559_RS08790	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HV559_RS08795	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HV559_RS08820	COG2350	Protein conserved in bacteria
HV559_RS08825	COG1607	acyl-coa hydrolase
HV559_RS08830	COG2917	probably involved in intracellular septation
HV559_RS08840	COG3092	negative regulation of chromosome organization
HV559_RS08850	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HV559_RS08855	COG0303	'Molybdopterin
HV559_RS08860	COG2095	MarC family integral membrane protein
HV559_RS08875	COG0564	pseudouridine synthase activity
HV559_RS08890	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HV559_RS08895	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HV559_RS08905	COG0823	Involved in the tonB-independent uptake of proteins
HV559_RS08910	COG3064	Membrane
HV559_RS08915	COG0848	biopolymer transport protein
HV559_RS08920	COG0811	peptide transport
HV559_RS08925	COG0824	Thioesterase
HV559_RS08940	COG1294	oxidase, subunit
HV559_RS08945	COG1271	oxidase subunit
HV559_RS08970	COG0494	nUDIX hydrolase
HV559_RS09000	COG0271	Belongs to the BolA IbaG family
HV559_RS09010	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HV559_RS09015	COG1678	Uncharacterized ACR, COG1678
HV559_RS09025	COG0628	permease
HV559_RS09030	COG1115	amino acid carrier protein
HV559_RS09035	COG1525	nuclease
HV559_RS09065	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HV559_RS09070	COG0205	6-phosphofructokinase activity
HV559_RS09085	COG0564	pseudouridine synthase activity
HV559_RS09090	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HV559_RS09095	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HV559_RS09100	COG1965	Belongs to the frataxin family
HV559_RS09110	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HV559_RS09115	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HV559_RS09120	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HV559_RS09130	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HV559_RS09140	COG1584	GPR1 FUN34 yaaH family protein
HV559_RS09160	COG0861	Integral membrane protein TerC family
HV559_RS09165	COG1472	Belongs to the glycosyl hydrolase 3 family
HV559_RS09180	COG4316	Uncharacterized protein conserved in bacteria (DUF2251)
HV559_RS09185	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HV559_RS09215	COG0385	Bile acid
HV559_RS09220	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
HV559_RS09235	COG1074	ATP-dependent DNA helicase activity
HV559_RS09245	COG0534	Mate efflux family protein
HV559_RS09250	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HV559_RS09255	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HV559_RS09265	COG1643	Atp-dependent helicase
HV559_RS09270	COG2990	Protein conserved in bacteria
HV559_RS09280	COG0330	HflC and HflK could
HV559_RS09285	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HV559_RS09295	COG2932	Transcriptional regulator
HV559_RS09300	COG0791	NLP P60 protein
HV559_RS09310	COG3381	protein complex oligomerization
HV559_RS09330	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HV559_RS09340	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HV559_RS09340	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HV559_RS09355	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HV559_RS09360	COG0583	DNA-binding transcription factor activity
HV559_RS09375	COG3306	glycosyltransferase involved in LPS biosynthesis
HV559_RS09405	COG1702	phosphate starvation-inducible protein PhoH
HV559_RS09420	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HV559_RS09425	COG0626	cystathionine gamma-synthase activity
HV559_RS09430	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HV559_RS09435	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HV559_RS09440	COG3023	N-Acetylmuramoyl-L-alanine amidase
HV559_RS09445	COG0564	pseudouridine synthase activity
HV559_RS09465	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HV559_RS09470	COG2814	Major facilitator Superfamily
HV559_RS09475	COG1187	pseudouridine synthase activity
HV559_RS09480	COG1441	menaquinone biosynthetic process
HV559_RS09495	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HV559_RS09510	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HV559_RS09515	COG1560	Kdo2-lipid A biosynthetic process
HV559_RS09520	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HV559_RS09525	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HV559_RS09525	COG0301	tRNA thio-modification
HV559_RS09530	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HV559_RS09555	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HV559_RS09560	COG0508	dehydrogenase complex catalyzes the overall conversion of
HV559_RS09565	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HV559_RS09570	COG0167	dihydroorotate dehydrogenase activity
HV559_RS09575	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HV559_RS09580	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HV559_RS09590	COG1132	(ABC) transporter
HV559_RS09595	COG1199	ATP-dependent helicase activity
HV559_RS09600	COG1122	ATPase activity
HV559_RS09610	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HV559_RS09615	COG0629	single-stranded DNA binding
HV559_RS09620	COG2610	gluconate transmembrane transporter activity
HV559_RS09625	COG3265	gluconokinase activity
HV559_RS09630	COG1609	Transcriptional regulator
HV559_RS09635	COG1253	flavin adenine dinucleotide binding
HV559_RS09640	COG2951	lytic endotransglycosylase activity
HV559_RS09645	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HV559_RS09650	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HV559_RS09655	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HV559_RS09660	COG0195	Participates in both transcription termination and antitermination
HV559_RS09665	COG0779	Required for maturation of 30S ribosomal subunits
HV559_RS09675	COG0741	lytic transglycosylase activity
HV559_RS09685	COG0330	HflC and HflK could
HV559_RS09690	COG0330	HflC and HflK could
HV559_RS09700	COG3091	SprT-like family
HV559_RS09705	COG3719	Belongs to the RNase T2 family
HV559_RS09745	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HV559_RS09750	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HV559_RS09755	COG4977	sequence-specific DNA binding
HV559_RS09755	COG1917	Cupin 2, conserved barrel domain protein
HV559_RS09760	COG3302	dmso reductase anchor subunit
HV559_RS09765	COG0437	4 iron, 4 sulfur cluster binding
HV559_RS09770	COG0243	molybdopterin cofactor binding
HV559_RS09775	COG3381	protein complex oligomerization
HV559_RS09805	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HV559_RS09830	COG0460	homoserine dehydrogenase
HV559_RS09830	COG0527	aspartate kinase activity
HV559_RS09835	COG0083	homoserine kinase activity
HV559_RS09840	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HV559_RS09845	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HV559_RS09850	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HV559_RS09850	COG2221	Nitrite and sulphite reductase 4Fe-4S
HV559_RS09855	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HV559_RS09870	COG0813	purine-nucleoside phosphorylase activity
HV559_RS09880	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HV559_RS09890	COG1216	Glycosyl transferase, family 2
HV559_RS09895	COG1216	Glycosyl transferase, family 2
HV559_RS09905	COG3306	glycosyltransferase involved in LPS biosynthesis
HV559_RS09915	COG2244	polysaccharide biosynthetic process
HV559_RS09925	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HV559_RS09930	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HV559_RS09935	COG0436	Aminotransferase
HV559_RS09950	COG2960	long-chain fatty acid transporting porin activity
HV559_RS09955	COG0166	Belongs to the GPI family
HV559_RS09960	COG4160	amino acid transport
HV559_RS09965	COG4215	(ABC) transporter
HV559_RS09970	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HV559_RS09975	COG1126	abc transporter atp-binding protein
HV559_RS09980	COG4232	protein-disulfide reductase activity
HV559_RS09985	COG3101	peptidyl-lysine hydroxylation
HV559_RS09990	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HV559_RS09995	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HV559_RS10000	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HV559_RS10005	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HV559_RS10045	COG0287	Prephenate dehydrogenase
HV559_RS10045	COG1605	Chorismate mutase
HV559_RS10050	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HV559_RS10055	COG0859	PFAM glycosyl transferase family 9
HV559_RS10060	COG0469	pyruvate kinase activity
HV559_RS10065	COG2062	phosphohistidine phosphatase, SixA
HV559_RS10070	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HV559_RS10080	COG1629	transport
HV559_RS10080	COG4771	TonB-dependent receptor
HV559_RS10090	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HV559_RS10095	COG0346	lactoylglutathione lyase activity
HV559_RS10105	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HV559_RS10110	COG0617	tRNA 3'-terminal CCA addition
HV559_RS10120	COG4143	(ABC) transporter
HV559_RS10125	COG0402	S-adenosylhomocysteine deaminase activity
HV559_RS10130	COG1538	Outer membrane efflux protein
HV559_RS10135	COG0194	GDP metabolic process
HV559_RS10140	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
HV559_RS10155	COG2195	Cleaves the N-terminal amino acid of tripeptides
HV559_RS10160	COG1560	Kdo2-lipid A biosynthetic process
HV559_RS10175	COG4658	electron transport chain
HV559_RS10180	COG2860	membrane
HV559_RS10185	COG4656	Part of a membrane complex involved in electron transport
HV559_RS10190	COG2878	Part of a membrane complex involved in electron transport
HV559_RS10195	COG4657	Part of a membrane complex involved in electron transport
HV559_RS10200	COG0488	(ABC) transporter
HV559_RS10210	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HV559_RS10215	COG0359	binds to the 23S rRNA
HV559_RS10225	COG2965	DNA replication, synthesis of RNA primer
HV559_RS10240	COG3266	domain, Protein
HV559_RS10255	COG3115	cell septum assembly
HV559_RS10270	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HV559_RS10275	COG2814	Major facilitator Superfamily
HV559_RS10285	COG2268	Band 7 protein
HV559_RS10290	COG0210	DNA helicase
HV559_RS10295	COG1090	epimerase
HV559_RS10300	COG1438	arginine binding
HV559_RS10315	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HV559_RS10325	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HV559_RS10335	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV559_RS10340	COG3715	PTS system
HV559_RS10345	COG3716	PTS system mannose fructose sorbose family IID component
HV559_RS10375	COG1666	GTP binding
HV559_RS10380	COG0560	Phosphoserine phosphatase
HV559_RS10390	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HV559_RS10395	COG2081	HI0933 family
HV559_RS10400	COG2252	PERMEase
HV559_RS10405	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HV559_RS10415	COG0716	FMN binding
HV559_RS10420	COG0735	belongs to the Fur family
HV559_RS10425	COG3008	intermembrane lipid transfer
HV559_RS10430	COG1854	S-ribosylhomocysteine lyase activity
HV559_RS10435	COG1132	(ABC) transporter