locus-tag	class	description
A6B40_RS00010	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
A6B40_RS00015	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A6B40_RS00025	COG0670	Belongs to the BI1 family
A6B40_RS00030	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A6B40_RS00045	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
A6B40_RS00050	COG0291	Belongs to the bacterial ribosomal protein bL35 family
A6B40_RS00055	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
A6B40_RS00065	COG1965	Belongs to the frataxin family
A6B40_RS00075	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
A6B40_RS00080	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A6B40_RS00085	COG0564	pseudouridine synthase activity
A6B40_RS00095	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
A6B40_RS00100	COG1560	Kdo2-lipid A biosynthetic process
A6B40_RS00105	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A6B40_RS00110	COG0814	amino acid
A6B40_RS00115	COG1760	l-serine dehydratase
A6B40_RS00130	COG2027	D-alanyl-D-alanine carboxypeptidase
A6B40_RS00135	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A6B40_RS00150	COG1441	menaquinone biosynthetic process
A6B40_RS00155	COG1187	pseudouridine synthase activity
A6B40_RS00160	COG2814	Major facilitator Superfamily
A6B40_RS00165	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A6B40_RS00170	COG0232	Belongs to the dGTPase family. Type 2 subfamily
A6B40_RS00190	COG0564	pseudouridine synthase activity
A6B40_RS00195	COG3023	N-Acetylmuramoyl-L-alanine amidase
A6B40_RS00200	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
A6B40_RS00220	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
A6B40_RS00240	COG1704	LemA family
A6B40_RS00245	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A6B40_RS00245	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
A6B40_RS00245	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A6B40_RS00250	COG1105	Belongs to the carbohydrate kinase PfkB family
A6B40_RS00255	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6B40_RS00255	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6B40_RS00260	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
A6B40_RS00265	COG1523	belongs to the glycosyl hydrolase 13 family
A6B40_RS00270	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
A6B40_RS00280	COG0058	SHG alpha-glucan phosphorylase activity
A6B40_RS00285	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
A6B40_RS00290	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
A6B40_RS00295	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
A6B40_RS00305	COG3381	protein complex oligomerization
A6B40_RS00315	COG0791	NLP P60 protein
A6B40_RS00320	COG2932	Transcriptional regulator
A6B40_RS00330	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
A6B40_RS00335	COG0330	HflC and HflK could
A6B40_RS00345	COG2990	Protein conserved in bacteria
A6B40_RS00355	COG1643	Atp-dependent helicase
A6B40_RS00375	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
A6B40_RS00380	COG0617	tRNA 3'-terminal CCA addition
A6B40_RS00385	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A6B40_RS00390	COG0730	response to heat
A6B40_RS00395	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
A6B40_RS00400	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
A6B40_RS00405	COG0583	DNA-binding transcription factor activity
A6B40_RS00415	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
A6B40_RS00425	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
A6B40_RS00430	COG4969	Belongs to the N-Me-Phe pilin family
A6B40_RS00435	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A6B40_RS00440	COG1459	type II secretion system
A6B40_RS00450	COG0237	dephospho-CoA kinase activity
A6B40_RS00455	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
A6B40_RS00460	COG1466	dna polymerase III delta subunit
A6B40_RS00465	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
A6B40_RS00470	COG0495	leucyl-tRNA aminoacylation
A6B40_RS00485	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
A6B40_RS00490	COG3106	COG3106 Predicted ATPase
A6B40_RS00495	COG3025	triphosphatase activity
A6B40_RS00505	COG3140	Belongs to the UPF0181 family
A6B40_RS00510	COG0564	pseudouridine synthase activity
A6B40_RS00515	COG3098	single-species biofilm formation
A6B40_RS00520	COG0134	indole-3-glycerol-phosphate synthase activity
A6B40_RS00520	COG0135	phosphoribosylanthranilate isomerase activity
A6B40_RS00525	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A6B40_RS00525	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
A6B40_RS00530	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A6B40_RS00535	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A6B40_RS00540	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A6B40_RS00555	COG0750	zinc metalloprotease
A6B40_RS00560	COG0575	Belongs to the CDS family
A6B40_RS00565	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
A6B40_RS00570	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
A6B40_RS00580	COG0581	inorganic phosphate transmembrane transporter activity
A6B40_RS00590	COG0745	RESPONSE REGULATOR receiver
A6B40_RS00595	COG5002	protein histidine kinase activity
A6B40_RS00600	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A6B40_RS00620	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
A6B40_RS00630	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
A6B40_RS00635	COG1253	flavin adenine dinucleotide binding
A6B40_RS00645	COG1982	Orn Lys Arg decarboxylase major
A6B40_RS00650	COG0531	amino acid
A6B40_RS00655	COG2831	hemolysin activation secretion protein
A6B40_RS00660	COG3210	domain, Protein
A6B40_RS00690	COG0629	single-stranded DNA binding
A6B40_RS00695	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A6B40_RS00700	COG0659	secondary active sulfate transmembrane transporter activity
A6B40_RS00715	COG1199	ATP-dependent helicase activity
A6B40_RS00725	COG1346	cytolysis
A6B40_RS00730	COG1132	(ABC) transporter
A6B40_RS00740	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
A6B40_RS00745	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
A6B40_RS00750	COG0167	dihydroorotate dehydrogenase activity
A6B40_RS00755	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
A6B40_RS00760	COG0508	dehydrogenase complex catalyzes the overall conversion of
A6B40_RS00765	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A6B40_RS00780	COG0741	lytic transglycosylase activity
A6B40_RS00790	COG0779	Required for maturation of 30S ribosomal subunits
A6B40_RS00795	COG0195	Participates in both transcription termination and antitermination
A6B40_RS00800	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
A6B40_RS00805	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
A6B40_RS00810	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
A6B40_RS00815	COG2951	lytic endotransglycosylase activity
A6B40_RS00820	COG0590	tRNA wobble adenosine to inosine editing
A6B40_RS00825	COG0513	Belongs to the DEAD box helicase family
A6B40_RS00830	COG4785	May be involved in cell division
A6B40_RS00835	COG1185	polyribonucleotide nucleotidyltransferase activity
A6B40_RS00840	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A6B40_RS00890	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
A6B40_RS00895	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
A6B40_RS00900	COG2814	Major facilitator Superfamily
A6B40_RS00905	COG3083	sulfuric ester hydrolase activity
A6B40_RS00915	COG1309	transcriptional regulator
A6B40_RS00920	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A6B40_RS00925	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A6B40_RS00935	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A6B40_RS00950	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
A6B40_RS00955	COG0387	Pfam Sodium calcium exchanger
A6B40_RS00960	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
A6B40_RS00965	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A6B40_RS00980	COG4991	sh3 domain protein
A6B40_RS00985	COG0306	phosphate transporter
A6B40_RS00990	COG1392	Phosphate transport regulator
A6B40_RS00995	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
A6B40_RS01010	COG3105	Protein conserved in bacteria
A6B40_RS01015	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
A6B40_RS01020	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
A6B40_RS01040	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
A6B40_RS01045	COG1823	symporter activity
A6B40_RS01050	COG0778	Nitroreductase
A6B40_RS01055	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
A6B40_RS01060	COG0072	phenylalanine-tRNA ligase activity
A6B40_RS01070	COG0791	NLP P60 protein
A6B40_RS01075	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A6B40_RS01085	COG0539	negative regulation of cytoplasmic translation
A6B40_RS01095	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
A6B40_RS01100	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
A6B40_RS01105	COG0284	orotidine-5'-phosphate decarboxylase activity
A6B40_RS01110	COG0023	Translation Initiation Factor
A6B40_RS01115	COG0737	Belongs to the 5'-nucleotidase family
A6B40_RS01120	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
A6B40_RS01125	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
A6B40_RS01130	COG0658	competence protein
A6B40_RS01130	COG2333	competence protein COMEC
A6B40_RS01135	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A6B40_RS01140	COG1151	hydroxylamine reductase activity
A6B40_RS01150	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
A6B40_RS01160	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
A6B40_RS01165	COG0625	glutathione transferase activity
A6B40_RS01170	COG2969	positive regulation of protein catabolic process
A6B40_RS01185	COG0583	DNA-binding transcription factor activity
A6B40_RS01190	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A6B40_RS01205	COG2226	methyltransferase
A6B40_RS01210	COG3036	rescue of stalled ribosome
A6B40_RS01215	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
A6B40_RS01220	COG1940	carbohydrate kinase activity
A6B40_RS01225	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
A6B40_RS01230	COG1522	sequence-specific DNA binding
A6B40_RS01235	COG1674	ftsk spoiiie
A6B40_RS01240	COG2321	neutral zinc metallopeptidase
A6B40_RS01245	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A6B40_RS01250	COG1214	PFAM Peptidase M22, glycoprotease
A6B40_RS01260	COG3074	FtsZ-dependent cytokinesis
A6B40_RS01265	COG1494	fructose-1,6-bisphosphatase
A6B40_RS01275	COG0006	proline dipeptidase activity
A6B40_RS01290	COG0440	acetolactate synthase activity
A6B40_RS01295	COG0028	Belongs to the TPP enzyme family
A6B40_RS01300	COG0288	reversible hydration of carbon dioxide
A6B40_RS01305	COG0857	belongs to the CobB CobQ family
A6B40_RS01305	COG0280	phosphate acetyltransferase
A6B40_RS01315	COG0737	Belongs to the 5'-nucleotidase family
A6B40_RS01325	COG0626	cystathionine gamma-synthase activity
A6B40_RS01340	COG2363	Small membrane protein
A6B40_RS01345	COG0243	molybdopterin cofactor binding
A6B40_RS01355	COG1049	propionate catabolic process, 2-methylcitrate cycle
A6B40_RS01360	COG0538	isocitrate dehydrogenase activity
A6B40_RS01380	COG0243	molybdopterin cofactor binding
A6B40_RS01385	COG3005	denitrification pathway
A6B40_RS01390	COG2909	trisaccharide binding
A6B40_RS01400	COG0315	cyclic pyranopterin monophosphate synthase activity
A6B40_RS01405	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
A6B40_RS01410	COG0314	molybdopterin synthase activity
A6B40_RS01415	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
A6B40_RS01420	COG1444	tRNA N-acetyltransferase activity
A6B40_RS01425	COG1448	Aminotransferase
A6B40_RS01430	COG0285	dihydrofolate synthase activity
A6B40_RS01440	COG3956	TIGRFAM MazG family protein
A6B40_RS01445	COG0745	RESPONSE REGULATOR receiver
A6B40_RS01450	COG2205	protein histidine kinase activity
A6B40_RS01455	COG1136	(ABC) transporter
A6B40_RS01455	COG0577	efflux transmembrane transporter activity
A6B40_RS01460	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
A6B40_RS01465	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A6B40_RS01470	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A6B40_RS01480	COG0697	spore germination
A6B40_RS01485	COG0084	hydrolase, TatD family'
A6B40_RS01500	COG0556	nucleotide-excision repair
A6B40_RS01510	COG2837	iron assimilation
A6B40_RS01520	COG4607	ABC-type enterochelin transport system periplasmic component
A6B40_RS01525	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A6B40_RS01530	COG4605	iron ion homeostasis
A6B40_RS01535	COG4604	ABC transporter, ATP-binding protein
A6B40_RS01540	COG0613	PHP domain protein
A6B40_RS01550	COG2925	Exonuclease
A6B40_RS01555	COG0017	Asparaginyl-tRNA synthetase
A6B40_RS01560	COG1509	lysine 2,3-aminomutase activity
A6B40_RS01570	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
A6B40_RS01575	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A6B40_RS01580	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
A6B40_RS01585	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A6B40_RS01610	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
A6B40_RS01615	COG0312	modulator of DNA gyrase
A6B40_RS01620	COG3028	Belongs to the UPF0307 family
A6B40_RS01625	COG3094	Invasion gene expression up-regulator, SirB
A6B40_RS01630	COG1811	Na channel or pump
A6B40_RS01640	COG3787	Belongs to the UPF0306 family
A6B40_RS01645	COG2207	Transcriptional regulator
A6B40_RS01650	COG4774	siderophore transport
A6B40_RS01665	COG3945	hemerythrin HHE cation binding domain
A6B40_RS01685	COG1278	Cold shock
A6B40_RS01690	COG0697	spore germination
A6B40_RS01695	COG1737	Transcriptional regulator
A6B40_RS01700	COG2731	YhcH YjgK YiaL family protein
A6B40_RS01710	COG2926	Belongs to the UPF0265 family
A6B40_RS01715	COG1263	PTS System
A6B40_RS01715	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A6B40_RS01715	COG2190	(PTS) system
A6B40_RS01720	COG0527	aspartate kinase activity
A6B40_RS01730	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
A6B40_RS01735	COG3100	YcgL domain-containing protein
A6B40_RS01740	COG0305	Participates in initiation and elongation during chromosome replication
A6B40_RS01755	COG1210	Utp--glucose-1-phosphate uridylyltransferase
A6B40_RS01765	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
A6B40_RS01775	COG0589	response to stress
A6B40_RS01785	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
A6B40_RS01795	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
A6B40_RS01805	COG0586	Pfam SNARE associated Golgi protein
A6B40_RS01815	COG2226	methyltransferase
A6B40_RS01820	COG0596	Alpha beta hydrolase
A6B40_RS01830	COG0318	PFAM AMP-dependent synthetase and ligase
A6B40_RS01835	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
A6B40_RS01835	COG3264	Mechanosensitive ion channel
A6B40_RS01845	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
A6B40_RS01855	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A6B40_RS01870	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A6B40_RS01880	COG3021	interspecies interaction between organisms
A6B40_RS01895	COG5645	(Lipo)protein
A6B40_RS01900	COG4172	Belongs to the ABC transporter superfamily
A6B40_RS01905	COG4171	peptide transport system, permease
A6B40_RS01910	COG4168	peptide transport system, permease
A6B40_RS01915	COG4166	transmembrane transport
A6B40_RS01920	COG3283	Transcriptional regulator of aromatic amino acids metabolism
A6B40_RS01925	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
A6B40_RS01930	COG2983	Belongs to the UPF0260 family
A6B40_RS01935	COG0393	Putative heavy-metal-binding
A6B40_RS01940	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
A6B40_RS01950	COG3850	Histidine kinase
A6B40_RS01955	COG0561	phosphatase activity
A6B40_RS01965	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
A6B40_RS01975	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A6B40_RS01980	COG0739	heme binding
A6B40_RS01985	COG1121	(ABC) transporter
A6B40_RS01990	COG0567	Dehydrogenase, E1 component
A6B40_RS01995	COG0508	dehydrogenase complex catalyzes the overall conversion of
A6B40_RS02000	COG0045	succinate-CoA ligase (ADP-forming) activity
A6B40_RS02005	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
A6B40_RS02010	COG1115	amino acid carrier protein
A6B40_RS02015	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
A6B40_RS02035	COG0281	malic enzyme
A6B40_RS02035	COG0280	phosphate acetyltransferase
A6B40_RS02040	COG0189	ligase activity
A6B40_RS02050	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A6B40_RS02060	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
A6B40_RS02065	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A6B40_RS02065	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A6B40_RS02070	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
A6B40_RS02075	COG4208	sulfate ABC transporter
A6B40_RS02080	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
A6B40_RS02085	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
A6B40_RS02115	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A6B40_RS02120	COG5339	Protein conserved in bacteria
A6B40_RS02130	COG0133	tryptophan synthase activity
A6B40_RS02135	COG4221	oxidoreductase activity
A6B40_RS02140	COG1757	Na H antiporter
A6B40_RS02145	COG2916	Histone family protein nucleoid-structuring protein H-NS
A6B40_RS02150	COG0788	formyltetrahydrofolate deformylase activity
A6B40_RS02155	COG2949	membrane
A6B40_RS02160	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A6B40_RS02165	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
A6B40_RS02170	COG1530	ribonuclease E activity
A6B40_RS02175	COG0187	DNA topoisomerase II activity
A6B40_RS02180	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
A6B40_RS02185	COG1349	DNA-binding transcription factor activity
A6B40_RS02190	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A6B40_RS02195	COG2915	High frequency lysogenization protein hflD homolog
A6B40_RS02200	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
A6B40_RS02205	COG4988	ABC transporter
A6B40_RS02210	COG2911	Protein conserved in bacteria
A6B40_RS02215	COG0729	surface antigen
A6B40_RS02220	COG2861	carbohydrate metabolic process
A6B40_RS02225	COG4942	peptidase
A6B40_RS02235	COG0233	cytoplasmic translational termination
A6B40_RS02240	COG0528	UMP kinase activity
A6B40_RS02245	COG2194	sulfuric ester hydrolase activity
A6B40_RS02260	COG1840	ABC-type Fe3 transport system, periplasmic component
A6B40_RS02270	COG3842	ATPase activity
A6B40_RS02275	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
A6B40_RS02280	COG0433	COG0433 Predicted ATPase
A6B40_RS02290	COG0513	Belongs to the DEAD box helicase family
A6B40_RS02300	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
A6B40_RS02310	COG0681	Belongs to the peptidase S26 family
A6B40_RS02315	COG0481	GTPase activity
A6B40_RS02320	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A6B40_RS02330	COG3069	C4-dicarboxylate transmembrane transporter activity
A6B40_RS02335	COG1473	amidohydrolase
A6B40_RS02340	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
A6B40_RS02345	COG1301	dicarboxylic acid transport
A6B40_RS02355	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A6B40_RS02360	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A6B40_RS02370	COG1620	l-lactate permease
A6B40_RS02375	COG0549	Belongs to the carbamate kinase family
A6B40_RS02380	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
A6B40_RS02385	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
A6B40_RS02390	COG3257	ureidoglycine aminohydrolase activity
A6B40_RS02400	COG1953	Uracil, thiamine, allantoin
A6B40_RS02430	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
A6B40_RS02445	COG1286	toxin biosynthetic process
A6B40_RS02450	COG0328	RNA-DNA hybrid ribonuclease activity
A6B40_RS02465	COG0859	PFAM glycosyl transferase family 9
A6B40_RS02470	COG0463	Glycosyl transferase, family 2
A6B40_RS02475	COG1534	Rna-binding protein
A6B40_RS02480	COG0671	phosphoesterase, PA-phosphatase related
A6B40_RS02485	COG1940	carbohydrate kinase activity
A6B40_RS02490	COG1368	sulfuric ester hydrolase activity
A6B40_RS02495	COG0633	Ferredoxin
A6B40_RS02495	COG3217	Mosc domain protein beta barrel domain protein
A6B40_RS02500	COG1722	exodeoxyribonuclease VII activity
A6B40_RS02505	COG0142	geranyltranstransferase activity
A6B40_RS02510	COG0121	glutamine amidotransferase
A6B40_RS02515	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A6B40_RS02520	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A6B40_RS02525	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
A6B40_RS02530	COG1792	Involved in formation and maintenance of cell shape
A6B40_RS02535	COG1077	Cell shape determining protein MreB Mrl
A6B40_RS02545	COG0572	uridine kinase
A6B40_RS02550	COG0717	Belongs to the dCTP deaminase family
A6B40_RS02560	COG0583	DNA-binding transcription factor activity
A6B40_RS02565	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A6B40_RS02580	COG2975	iron-sulfur cluster assembly
A6B40_RS02585	COG0633	Ferredoxin
A6B40_RS02605	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
A6B40_RS02615	COG0822	iron-sulfur transferase activity
A6B40_RS02625	COG1959	2 iron, 2 sulfur cluster binding
A6B40_RS02635	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A6B40_RS02640	COG2198	Histidine kinase
A6B40_RS02640	COG5002	protein histidine kinase activity
A6B40_RS02640	COG0784	Response regulator, receiver
A6B40_RS02650	COG0697	spore germination
A6B40_RS02660	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
A6B40_RS02665	COG2840	Smr protein MutS2
A6B40_RS02675	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
A6B40_RS02680	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
A6B40_RS02685	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
A6B40_RS02685	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
A6B40_RS02690	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
A6B40_RS02695	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
A6B40_RS02700	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A6B40_RS02705	COG4166	transmembrane transport
A6B40_RS02715	COG0444	Belongs to the ABC transporter superfamily
A6B40_RS02720	COG4608	Belongs to the ABC transporter superfamily
A6B40_RS02725	COG0519	Catalyzes the synthesis of GMP from XMP
A6B40_RS02730	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
A6B40_RS02745	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A6B40_RS02755	COG1160	GTP binding
A6B40_RS02760	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
A6B40_RS02760	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
A6B40_RS02765	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
A6B40_RS02770	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A6B40_RS02775	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A6B40_RS02780	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
A6B40_RS02785	COG0318	PFAM AMP-dependent synthetase and ligase
A6B40_RS02795	COG3026	antisigma factor binding
A6B40_RS02800	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
A6B40_RS02805	COG1595	DNA-templated transcription, initiation
A6B40_RS02815	COG0561	phosphatase activity
A6B40_RS02820	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A6B40_RS02825	COG0385	Bile acid
A6B40_RS02830	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
A6B40_RS02845	COG1074	ATP-dependent DNA helicase activity
A6B40_RS02850	COG0534	Mate efflux family protein
A6B40_RS02865	COG0815	Transfers the fatty acyl group on membrane lipoproteins
A6B40_RS02890	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
A6B40_RS02900	COG1518	maintenance of DNA repeat elements
A6B40_RS02940	COG1944	ATP diphosphatase activity
A6B40_RS02945	COG0500	methyltransferase
A6B40_RS02950	COG0583	DNA-binding transcription factor activity
A6B40_RS02975	COG1702	phosphate starvation-inducible protein PhoH
A6B40_RS02990	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
A6B40_RS02995	COG0626	cystathionine gamma-synthase activity
A6B40_RS03000	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
A6B40_RS03005	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A6B40_RS03030	COG2350	Protein conserved in bacteria
A6B40_RS03035	COG1607	acyl-coa hydrolase
A6B40_RS03040	COG2917	probably involved in intracellular septation
A6B40_RS03050	COG3092	negative regulation of chromosome organization
A6B40_RS03060	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A6B40_RS03065	COG0303	'Molybdopterin
A6B40_RS03070	COG2095	MarC family integral membrane protein
A6B40_RS03095	COG0564	pseudouridine synthase activity
A6B40_RS03110	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A6B40_RS03120	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
A6B40_RS03135	COG0823	Involved in the tonB-independent uptake of proteins
A6B40_RS03140	COG3064	Membrane
A6B40_RS03140	COG3064	Membrane
A6B40_RS03145	COG0848	biopolymer transport protein
A6B40_RS03150	COG0811	peptide transport
A6B40_RS03155	COG0824	Thioesterase
A6B40_RS03170	COG1294	oxidase, subunit
A6B40_RS03175	COG1271	oxidase subunit
A6B40_RS03200	COG0494	nUDIX hydrolase
A6B40_RS03230	COG0271	Belongs to the BolA IbaG family
A6B40_RS03240	COG1385	rRNA (uridine-N3-)-methyltransferase activity
A6B40_RS03245	COG1678	Uncharacterized ACR, COG1678
A6B40_RS03255	COG0628	permease
A6B40_RS03260	COG1115	amino acid carrier protein
A6B40_RS03265	COG1525	nuclease
A6B40_RS03270	COG3047	cAMP biosynthetic process
A6B40_RS03275	COG0542	response to heat
A6B40_RS03280	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
A6B40_RS03285	COG0471	metal ion transport
A6B40_RS03290	COG0295	cytidine deaminase activity
A6B40_RS03295	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
A6B40_RS03305	COG0187	DNA topoisomerase II activity
A6B40_RS03310	COG0789	Transcriptional regulator
A6B40_RS03320	COG2608	mercury ion transmembrane transporter activity
A6B40_RS03325	COG2217	Heavy metal translocating P-type atpase
A6B40_RS03335	COG0302	gtp cyclohydrolase
A6B40_RS03345	COG0489	protein tyrosine kinase activity
A6B40_RS03350	COG4166	transmembrane transport
A6B40_RS03355	COG2095	MarC family integral membrane protein
A6B40_RS03360	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A6B40_RS03365	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
A6B40_RS03370	COG2354	Protein conserved in bacteria
A6B40_RS03375	COG2999	glutathione oxidoreductase activity
A6B40_RS03380	COG3071	HemY protein
A6B40_RS03385	COG2959	enzyme of heme biosynthesis
A6B40_RS03395	COG0181	hydroxymethylbilane synthase activity
A6B40_RS03400	COG1454	alcohol dehydrogenase
A6B40_RS03400	COG1012	belongs to the aldehyde dehydrogenase family
A6B40_RS03405	COG1538	Outer membrane efflux protein
A6B40_RS03410	COG0842	Transport permease protein
A6B40_RS03415	COG0842	Transport permease protein
A6B40_RS03415	COG1129	ABC transporter
A6B40_RS03420	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A6B40_RS03435	COG0531	amino acid
A6B40_RS03445	COG1388	LysM domain
A6B40_RS03445	COG0860	N-Acetylmuramoyl-L-alanine amidase
A6B40_RS03450	COG0802	atpase or kinase
A6B40_RS03455	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
A6B40_RS03465	COG1519	Transferase
A6B40_RS03485	COG0795	lipopolysaccharide-transporting ATPase activity
A6B40_RS03490	COG0795	lipopolysaccharide-transporting ATPase activity
A6B40_RS03500	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
A6B40_RS03505	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A6B40_RS03510	COG1349	DNA-binding transcription factor activity
A6B40_RS03520	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A6B40_RS03525	COG0738	Major facilitator superfamily
A6B40_RS03535	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
A6B40_RS03540	COG2221	Nitrite and sulphite reductase 4Fe-4S
A6B40_RS03540	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
A6B40_RS03545	COG3381	protein complex oligomerization
A6B40_RS03550	COG3302	dmso reductase anchor subunit
A6B40_RS03555	COG0437	4 iron, 4 sulfur cluster binding
A6B40_RS03560	COG0243	molybdopterin cofactor binding
A6B40_RS03565	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A6B40_RS03575	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
A6B40_RS03580	COG0813	purine-nucleoside phosphorylase activity
A6B40_RS03590	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A6B40_RS03595	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A6B40_RS03595	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A6B40_RS03600	COG1216	Glycosyl transferase, family 2
A6B40_RS03605	COG1216	Glycosyl transferase, family 2
A6B40_RS03615	COG3306	glycosyltransferase involved in LPS biosynthesis
A6B40_RS03625	COG2244	polysaccharide biosynthetic process
A6B40_RS03640	COG2089	acid synthase
A6B40_RS03650	COG1434	Gram-negative-bacterium-type cell wall biogenesis
A6B40_RS03655	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
A6B40_RS03665	COG2962	Rard protein
A6B40_RS03670	COG0436	Aminotransferase
A6B40_RS03675	COG1169	isochorismate synthase
A6B40_RS03685	COG0602	queuosine metabolic process
A6B40_RS03690	COG0720	synthase
A6B40_RS03695	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
A6B40_RS03700	COG2960	long-chain fatty acid transporting porin activity
A6B40_RS03705	COG0166	Belongs to the GPI family
A6B40_RS03735	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A6B40_RS03740	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A6B40_RS03750	COG0460	homoserine dehydrogenase
A6B40_RS03750	COG0527	aspartate kinase activity
A6B40_RS03755	COG0083	homoserine kinase activity
A6B40_RS03760	COG3593	DNA synthesis involved in DNA repair
A6B40_RS03765	COG1611	Belongs to the LOG family
A6B40_RS03770	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
A6B40_RS03780	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A6B40_RS03790	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A6B40_RS03805	COG4580	involved in the transport of maltose and maltodextrins
A6B40_RS03810	COG3842	ATPase activity
A6B40_RS03820	COG1175	transmembrane transport
A6B40_RS03825	COG3833	ABC-type maltose transport systems, permease component
A6B40_RS03830	COG2909	trisaccharide binding
A6B40_RS03835	COG0058	SHG alpha-glucan phosphorylase activity
A6B40_RS03840	COG1640	4-alpha-glucanotransferase
A6B40_RS03850	COG2056	Na+-H+ antiporter family
A6B40_RS03855	COG0708	Exodeoxyribonuclease III
A6B40_RS03860	COG3117	lipopolysaccharide transmembrane transporter activity
A6B40_RS03865	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
A6B40_RS03870	COG1137	ATPase activity
A6B40_RS03875	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6B40_RS03885	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A6B40_RS03900	COG2177	Part of the ABC transporter FtsEX involved in
A6B40_RS03905	COG2884	Cell division ATP-binding protein ftsE
A6B40_RS03910	COG0552	protein localization to endoplasmic reticulum
A6B40_RS03915	COG0742	ribosomal rna small subunit methyltransferase
A6B40_RS03920	COG3099	Belongs to the UPF0263 family
A6B40_RS03935	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
A6B40_RS03940	COG3326	Membrane
A6B40_RS03945	COG1027	Aspartate ammonia-lyase
A6B40_RS03950	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
A6B40_RS03955	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A6B40_RS03960	COG2207	Transcriptional regulator
A6B40_RS03970	COG1764	response to oxidative stress
A6B40_RS03975	COG0583	DNA-binding transcription factor activity
A6B40_RS03990	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
A6B40_RS03995	COG1966	Carbon starvation protein
A6B40_RS04000	COG0084	hydrolase, TatD family'
A6B40_RS04025	COG4591	ABC-type transport system involved in lipoprotein release permease component
A6B40_RS04030	COG1136	(ABC) transporter
A6B40_RS04040	COG4591	ABC-type transport system involved in lipoprotein release permease component
A6B40_RS04070	COG0512	Glutamine amidotransferase of anthranilate synthase
A6B40_RS04075	COG1322	Protein conserved in bacteria
A6B40_RS04075	COG1322	Protein conserved in bacteria
A6B40_RS04085	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A6B40_RS04095	COG2137	regulation of response to DNA damage stimulus
A6B40_RS04105	COG0551	DNA topoisomerase type I activity
A6B40_RS04115	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A6B40_RS04140	COG0210	DNA helicase
A6B40_RS04145	COG1090	epimerase
A6B40_RS04150	COG1438	arginine binding
A6B40_RS04170	COG1666	GTP binding
A6B40_RS04175	COG0560	Phosphoserine phosphatase
A6B40_RS04185	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
A6B40_RS04190	COG2081	HI0933 family
A6B40_RS04195	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
A6B40_RS04200	COG2252	PERMEase
A6B40_RS04205	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A6B40_RS04215	COG0716	FMN binding
A6B40_RS04220	COG0735	belongs to the Fur family
A6B40_RS04225	COG3008	intermembrane lipid transfer
A6B40_RS04230	COG1854	S-ribosylhomocysteine lyase activity
A6B40_RS04235	COG1132	(ABC) transporter
A6B40_RS04240	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
A6B40_RS04245	COG0592	DNA-directed DNA polymerase activity
A6B40_RS04250	COG2976	Protein conserved in bacteria
A6B40_RS04260	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
A6B40_RS04265	COG1426	Protein conserved in bacteria
A6B40_RS04280	COG2991	Protein conserved in bacteria
A6B40_RS04285	COG1477	protein flavinylation
A6B40_RS04290	COG2871	sodium ion transport
A6B40_RS04295	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
A6B40_RS04300	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
A6B40_RS04305	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
A6B40_RS04310	COG1805	sodium ion transport
A6B40_RS04320	COG0316	Belongs to the HesB IscA family
A6B40_RS04320	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
A6B40_RS04340	COG0583	DNA-binding transcription factor activity
A6B40_RS04345	COG1011	Hydrolase
A6B40_RS04350	COG0583	DNA-binding transcription factor activity
A6B40_RS04355	COG1162	GTPase activity
A6B40_RS04365	COG0537	adenosine 5'-monophosphoramidase activity
A6B40_RS04375	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A6B40_RS04380	COG3108	Peptidase M15
A6B40_RS04385	COG2989	Protein conserved in bacteria
A6B40_RS04390	COG0793	Belongs to the peptidase S41A family
A6B40_RS04395	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
A6B40_RS04405	COG2814	Major facilitator Superfamily
A6B40_RS04410	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A6B40_RS04420	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A6B40_RS04445	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
A6B40_RS04450	COG0792	nuclease activity
A6B40_RS04455	COG3107	peptidoglycan biosynthetic process
A6B40_RS04465	COG1858	cytochrome C peroxidase
A6B40_RS04475	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A6B40_RS04480	COG1414	Transcriptional regulator
A6B40_RS04485	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
A6B40_RS04495	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
A6B40_RS04510	COG3068	Protein conserved in bacteria
A6B40_RS04525	COG1530	ribonuclease E activity
A6B40_RS04530	COG1755	Isoprenylcysteine carboxyl methyltransferase
A6B40_RS04540	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
A6B40_RS04550	COG2824	Alkylphosphonate utilization operon protein PhnA
A6B40_RS04555	COG0557	exoribonuclease II activity
A6B40_RS04575	COG3116	cell division
A6B40_RS04580	COG0768	penicillin binding
A6B40_RS04585	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A6B40_RS04595	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A6B40_RS04600	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A6B40_RS04605	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
A6B40_RS04610	COG0772	Belongs to the SEDS family
A6B40_RS04615	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A6B40_RS04625	COG1181	Belongs to the D-alanine--D-alanine ligase family
A6B40_RS04635	COG0849	cell division
A6B40_RS04645	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
A6B40_RS04650	COG0497	DNA recombination
A6B40_RS04715	COG1652	LysM domain
A6B40_RS04720	COG2927	DNA polymerase III (CHI subunit)
A6B40_RS04725	COG2153	protein acetylation
A6B40_RS04735	COG4185	zeta toxin
A6B40_RS04755	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
A6B40_RS04760	COG1794	racemase activity, acting on amino acids and derivatives
A6B40_RS04770	COG0363	glucosamine-6-phosphate deaminase activity
A6B40_RS04775	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
A6B40_RS04780	COG1218	3'(2'),5'-bisphosphate nucleotidase
A6B40_RS04785	COG0494	nUDIX hydrolase
A6B40_RS04790	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
A6B40_RS04805	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
A6B40_RS04810	COG0456	acetyltransferase
A6B40_RS04820	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
A6B40_RS04825	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
A6B40_RS04835	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A6B40_RS04845	COG1045	serine acetyltransferase
A6B40_RS04855	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
A6B40_RS04860	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A6B40_RS04865	COG0544	peptidyl-prolyl cis-trans isomerase activity
A6B40_RS04880	COG0049	tRNA binding
A6B40_RS04890	COG0859	PFAM glycosyl transferase family 9
A6B40_RS04895	COG0859	PFAM glycosyl transferase family 9
A6B40_RS04905	COG3061	Opacity-associated protein A
A6B40_RS04905	COG3266	domain, Protein
A6B40_RS04910	COG1555	photosystem II stabilization
A6B40_RS04915	COG0688	phosphatidylethanolamine metabolic process
A6B40_RS04930	COG3715	PTS system
A6B40_RS04935	COG3716	PTS system mannose fructose sorbose family IID component
A6B40_RS04940	COG4811	Protein of unknown function (DUF986)
A6B40_RS04955	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
A6B40_RS04960	COG1238	metal cluster binding
A6B40_RS04975	COG1388	LysM domain
A6B40_RS04975	COG4942	peptidase
A6B40_RS04980	COG2818	Glycosylase
A6B40_RS04990	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
A6B40_RS05000	COG0257	Belongs to the bacterial ribosomal protein bL36 family
A6B40_RS05005	COG0762	integral membrane protein
A6B40_RS05010	COG3171	Protein conserved in bacteria
A6B40_RS05015	COG0220	tRNA (guanine-N7-)-methyltransferase activity
A6B40_RS05020	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A6B40_RS05030	COG0805	protein transport
A6B40_RS05035	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A6B40_RS05040	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A6B40_RS05045	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
A6B40_RS05055	COG2226	methyltransferase
A6B40_RS05060	COG0598	Magnesium transport protein CorA
A6B40_RS05070	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A6B40_RS05080	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
A6B40_RS05085	COG2910	NAD(P)H-binding
A6B40_RS05100	COG1064	alcohol dehydrogenase
A6B40_RS05105	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
A6B40_RS05120	COG0778	Nitroreductase
A6B40_RS05125	COG1902	pentaerythritol trinitrate reductase activity
A6B40_RS05130	COG0583	DNA-binding transcription factor activity
A6B40_RS05135	COG0431	NADPH-dependent FMN reductase
A6B40_RS05150	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
A6B40_RS05155	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A6B40_RS05160	COG0783	Belongs to the Dps family
A6B40_RS05170	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
A6B40_RS05175	COG0668	transmembrane transport
A6B40_RS05180	COG0564	pseudouridine synthase activity
A6B40_RS05190	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
A6B40_RS05195	COG1393	Belongs to the ArsC family
A6B40_RS05200	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A6B40_RS05210	COG2391	methyltransferase activity
A6B40_RS05215	COG0425	Belongs to the sulfur carrier protein TusA family
A6B40_RS05220	COG0753	catalase activity
A6B40_RS05240	COG0347	Belongs to the P(II) protein family
A6B40_RS05255	COG2259	Doxx family
A6B40_RS05260	COG1040	competence protein
A6B40_RS05265	COG0561	phosphatase activity
A6B40_RS05275	COG0261	This protein binds to 23S rRNA in the presence of protein L20
A6B40_RS05280	COG0142	geranyltranstransferase activity
A6B40_RS05285	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
A6B40_RS05290	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
A6B40_RS05300	COG1028	Short-chain dehydrogenase reductase Sdr
A6B40_RS05305	COG1114	Component of the transport system for branched-chain amino acids
A6B40_RS05315	COG1490	D-aminoacyl-tRNA deacylase activity
A6B40_RS05320	COG1295	ribonuclease BN
A6B40_RS05345	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A6B40_RS05360	COG1858	cytochrome C peroxidase
A6B40_RS05365	COG1309	transcriptional regulator
A6B40_RS05370	COG0583	DNA-binding transcription factor activity
A6B40_RS05375	COG0180	Tryptophanyl-tRNA synthetase
A6B40_RS05390	COG0730	response to heat
A6B40_RS05400	COG4145	pantothenate transmembrane transporter activity
A6B40_RS05405	COG3924	membrane
A6B40_RS05410	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
A6B40_RS05415	COG2853	Lipoprotein
A6B40_RS05420	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A6B40_RS05425	COG0501	Belongs to the peptidase M48B family
A6B40_RS05430	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
A6B40_RS05450	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
A6B40_RS05455	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
A6B40_RS05460	COG0470	DNA polymerase III
A6B40_RS05465	COG0084	hydrolase, TatD family'
A6B40_RS05475	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A6B40_RS05480	COG1216	Glycosyl transferase, family 2
A6B40_RS05525	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
A6B40_RS05540	COG0174	glutamine synthetase
A6B40_RS05545	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A6B40_RS05555	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
A6B40_RS05565	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A6B40_RS05585	COG0085	RNA polymerase activity
A6B40_RS05595	COG2168	tRNA wobble position uridine thiolation
A6B40_RS05605	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
A6B40_RS05610	COG2964	Protein conserved in bacteria
A6B40_RS05615	COG0545	Peptidyl-prolyl cis-trans isomerase
A6B40_RS05620	COG2900	Belongs to the SlyX family
A6B40_RS05625	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A6B40_RS05630	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A6B40_RS05635	COG3914	O-linked N-acetylglucosamine transferase SPINDLY family
A6B40_RS05640	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A6B40_RS05645	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
A6B40_RS05650	COG1328	CTP reductase activity
A6B40_RS05675	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
A6B40_RS05680	COG1785	Belongs to the alkaline phosphatase family
A6B40_RS05690	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A6B40_RS05695	COG0758	DNA mediated transformation
A6B40_RS05715	COG1067	ATP-dependent peptidase activity
A6B40_RS05720	COG3120	sequence-specific DNA binding
A6B40_RS05725	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
A6B40_RS05725	COG2885	chlorophyll binding
A6B40_RS05735	COG0247	lactate metabolic process
A6B40_RS05735	COG0277	FAD linked oxidase domain protein
A6B40_RS05740	COG2050	protein possibly involved in aromatic compounds catabolism
A6B40_RS05755	COG0204	Acyl-transferase
A6B40_RS05765	COG0825	malonyl-CoA metabolic process
A6B40_RS05810	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A6B40_RS05825	COG0521	Mo-molybdopterin cofactor biosynthetic process
A6B40_RS05835	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
A6B40_RS05845	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
A6B40_RS05855	COG3085	chromosome segregation
A6B40_RS05875	COG2832	Protein of unknown function (DUF454)
A6B40_RS05890	COG2964	Protein conserved in bacteria
A6B40_RS05920	COG2852	Protein conserved in bacteria
A6B40_RS05925	COG4545	Glutaredoxin-related protein
A6B40_RS05945	COG0235	Class ii aldolase
A6B40_RS05950	COG3623	hexulose-6-phosphate isomerase
A6B40_RS05970	COG0737	Belongs to the 5'-nucleotidase family
A6B40_RS05980	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
A6B40_RS05985	COG1929	Belongs to the glycerate kinase type-1 family
A6B40_RS05990	COG2610	gluconate transmembrane transporter activity
A6B40_RS05995	COG3835	regulator
A6B40_RS06000	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6B40_RS06005	COG1126	abc transporter atp-binding protein
A6B40_RS06015	COG0765	amino acid transport
A6B40_RS06035	COG0840	transmembrane signaling receptor activity
A6B40_RS06060	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
A6B40_RS06065	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
A6B40_RS06070	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
A6B40_RS06080	COG0089	rRNA binding
A6B40_RS06085	COG0088	Forms part of the polypeptide exit tunnel
A6B40_RS06090	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
A6B40_RS06095	COG0051	transcription antitermination factor activity, RNA binding
A6B40_RS06100	COG3070	regulator of competence-specific genes
A6B40_RS06115	COG0019	diaminopimelate decarboxylase activity
A6B40_RS06120	COG0625	glutathione transferase activity
A6B40_RS06135	COG2264	protein methyltransferase activity
A6B40_RS06140	COG0673	inositol 2-dehydrogenase activity
A6B40_RS06155	COG1595	DNA-templated transcription, initiation
A6B40_RS06160	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
A6B40_RS06170	COG0252	asparaginase activity
A6B40_RS06190	COG1349	DNA-binding transcription factor activity
A6B40_RS06195	COG2407	Converts the aldose L-fucose into the corresponding ketose L-fuculose
A6B40_RS06200	COG1070	Carbohydrate kinase
A6B40_RS06205	COG4154	Belongs to the RbsD FucU family
A6B40_RS06210	COG0235	Class ii aldolase
A6B40_RS06215	COG0738	Major facilitator superfamily
A6B40_RS06220	COG1454	alcohol dehydrogenase
A6B40_RS06225	COG1012	belongs to the aldehyde dehydrogenase family
A6B40_RS06230	COG3477	response to acidic pH
A6B40_RS06235	COG0569	domain protein
A6B40_RS06240	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A6B40_RS06255	COG2358	TRAP transporter, solute receptor (TAXI family
A6B40_RS06260	COG4206	TonB-dependent receptor
A6B40_RS06260	COG1629	transport
A6B40_RS06265	COG3276	selenocysteine insertion sequence binding
A6B40_RS06285	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
A6B40_RS06295	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A6B40_RS06300	COG0716	FMN binding
A6B40_RS06310	COG2160	L-arabinose isomerase activity
A6B40_RS06320	COG3254	rhamnose metabolic process
A6B40_RS06330	COG0235	Class ii aldolase
A6B40_RS06335	COG4806	L-rhamnose isomerase
A6B40_RS06340	COG1070	Carbohydrate kinase
A6B40_RS06345	COG4977	sequence-specific DNA binding
A6B40_RS06355	COG1172	Belongs to the binding-protein-dependent transport system permease family
A6B40_RS06360	COG1129	ABC transporter
A6B40_RS06365	COG1879	ABC-type sugar transport system periplasmic component
A6B40_RS06370	COG0442	prolyl-tRNA aminoacylation
A6B40_RS06390	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
A6B40_RS06400	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A6B40_RS06410	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A6B40_RS06410	COG1522	sequence-specific DNA binding
A6B40_RS06415	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A6B40_RS06425	COG3012	SEC-C Motif Domain Protein
A6B40_RS06430	COG0445	tRNA wobble uridine modification
A6B40_RS06435	COG0357	Ribosomal RNA small subunit methyltransferase G
A6B40_RS06455	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
A6B40_RS06460	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A6B40_RS06490	COG2502	aspartate--ammonia ligase
A6B40_RS06495	COG1522	sequence-specific DNA binding
A6B40_RS06505	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
A6B40_RS06510	COG3161	chorismate lyase activity
A6B40_RS06555	COG4974	Belongs to the 'phage' integrase family
A6B40_RS06560	COG0037	tRNA processing
A6B40_RS06565	COG2814	Major facilitator Superfamily
A6B40_RS06590	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A6B40_RS06595	COG0545	Peptidyl-prolyl cis-trans isomerase
A6B40_RS06625	COG0800	Aldolase
A6B40_RS06630	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A6B40_RS06640	COG1028	Short-chain dehydrogenase reductase Sdr
A6B40_RS06650	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
A6B40_RS06665	COG2186	Transcriptional regulator
A6B40_RS06670	COG1312	Catalyzes the dehydration of D-mannonate
A6B40_RS06680	COG0799	negative regulation of ribosome biogenesis
A6B40_RS06690	COG0768	penicillin binding
A6B40_RS06695	COG0772	Belongs to the SEDS family
A6B40_RS06700	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
A6B40_RS06705	COG1686	Belongs to the peptidase S11 family
A6B40_RS06715	COG0321	lipoyl(octanoyl) transferase activity
A6B40_RS06720	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
A6B40_RS06730	COG1119	ATPase activity
A6B40_RS06740	COG1739	Uncharacterized protein family UPF0029
A6B40_RS06745	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A6B40_RS06755	COG1970	mechanosensitive ion channel activity
A6B40_RS06765	COG0728	peptidoglycan biosynthetic process
A6B40_RS06775	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A6B40_RS06780	COG2223	nitrite transmembrane transporter activity
A6B40_RS06790	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
A6B40_RS06795	COG1053	succinate dehydrogenase
A6B40_RS06800	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
A6B40_RS06805	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
A6B40_RS06810	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
A6B40_RS06850	COG1305	Transglutaminase-like
A6B40_RS06860	COG2608	mercury ion transmembrane transporter activity
A6B40_RS06865	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
A6B40_RS06865	COG0517	IMP dehydrogenase activity
A6B40_RS06880	COG3722	fumarate hydratase activity
A6B40_RS06885	COG0471	metal ion transport
A6B40_RS06885	COG0490	domain, Protein
A6B40_RS06890	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
A6B40_RS06895	COG2731	YhcH YjgK YiaL family protein
A6B40_RS06900	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
A6B40_RS06905	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
A6B40_RS06910	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
A6B40_RS06915	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
A6B40_RS06920	COG1879	ABC-type sugar transport system periplasmic component
A6B40_RS06930	COG1172	Belongs to the binding-protein-dependent transport system permease family
A6B40_RS06940	COG4575	ribosome binding
A6B40_RS06960	COG2271	Major facilitator Superfamily
A6B40_RS06965	COG0584	glycerophosphoryl diester phosphodiesterase
A6B40_RS06980	COG1840	ABC-type Fe3 transport system, periplasmic component
A6B40_RS06990	COG1349	DNA-binding transcription factor activity
A6B40_RS06995	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A6B40_RS07015	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
A6B40_RS07020	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
A6B40_RS07025	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
A6B40_RS07035	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
A6B40_RS07045	COG0200	Binds to the 23S rRNA
A6B40_RS07050	COG0201	protein transport
A6B40_RS07060	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
A6B40_RS07070	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
A6B40_RS07075	COG0202	RNA polymerase activity
A6B40_RS07085	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A6B40_RS07110	COG0741	lytic transglycosylase activity
A6B40_RS07115	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
A6B40_RS07120	COG1194	a g-specific adenine glycosylase
A6B40_RS07125	COG0346	lactoylglutathione lyase activity
A6B40_RS07130	COG0697	spore germination
A6B40_RS07185	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
A6B40_RS07190	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A6B40_RS07195	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
A6B40_RS07200	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
A6B40_RS07210	COG3545	Serine hydrolase
A6B40_RS07220	COG1070	Carbohydrate kinase
A6B40_RS07230	COG4213	ABC transporter substrate-binding protein
A6B40_RS07235	COG1129	ABC transporter
A6B40_RS07240	COG4214	carbohydrate transport
A6B40_RS07245	COG0477	Major facilitator Superfamily
A6B40_RS07245	COG2814	Major facilitator Superfamily
A6B40_RS07250	COG0667	Aldo Keto reductase
A6B40_RS07255	COG1609	Transcriptional regulator
A6B40_RS07255	COG2207	Transcriptional regulator
A6B40_RS07260	COG1609	Transcriptional regulator
A6B40_RS07265	COG3265	gluconokinase activity
A6B40_RS07270	COG2610	gluconate transmembrane transporter activity
A6B40_RS07275	COG1012	belongs to the aldehyde dehydrogenase family
A6B40_RS07280	COG3718	enzyme involved in inositol metabolism
A6B40_RS07295	COG1129	ABC transporter
A6B40_RS07300	COG1172	Belongs to the binding-protein-dependent transport system permease family
A6B40_RS07305	COG0673	inositol 2-dehydrogenase activity
A6B40_RS07310	COG0673	inositol 2-dehydrogenase activity
A6B40_RS07320	COG3962	Belongs to the TPP enzyme family
A6B40_RS07335	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A6B40_RS07350	COG0228	four-way junction DNA binding
A6B40_RS07355	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
A6B40_RS07360	COG0336	Belongs to the RNA methyltransferase TrmD family
A6B40_RS07370	COG1694	Mazg nucleotide pyrophosphohydrolase
A6B40_RS07375	COG2850	peptidyl-arginine hydroxylation
A6B40_RS07380	COG0439	Biotin carboxylase
A6B40_RS07385	COG0511	ligase activity, forming carbon-carbon bonds
A6B40_RS07395	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
A6B40_RS07405	COG3711	transcriptional antiterminator
A6B40_RS07410	COG2723	6-phospho-beta-galactosidase activity
A6B40_RS07415	COG2190	(PTS) system
A6B40_RS07415	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A6B40_RS07415	COG1263	PTS System
A6B40_RS07420	COG1876	peptidase activity
A6B40_RS07425	COG0742	ribosomal rna small subunit methyltransferase
A6B40_RS07430	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
A6B40_RS07435	COG3047	cAMP biosynthetic process
A6B40_RS07435	COG2885	chlorophyll binding
A6B40_RS07440	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A6B40_RS07450	COG0606	chelatase, subunit chli
A6B40_RS07455	COG2267	carboxylic ester hydrolase activity
A6B40_RS07485	COG3691	Protein conserved in bacteria
A6B40_RS07490	COG1879	ABC-type sugar transport system periplasmic component
A6B40_RS07495	COG1879	ABC-type sugar transport system periplasmic component
A6B40_RS07505	COG4211	Belongs to the binding-protein-dependent transport system permease family
A6B40_RS07510	COG0747	negative chemotaxis
A6B40_RS07520	COG4795	General secretion pathway protein
A6B40_RS07535	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
A6B40_RS07540	COG1025	Belongs to the peptidase M16 family
A6B40_RS07545	COG0747	negative chemotaxis
A6B40_RS07550	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
A6B40_RS07550	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
A6B40_RS07555	COG0812	UDP-N-acetylmuramate dehydrogenase activity
A6B40_RS07570	COG1309	transcriptional regulator
A6B40_RS07580	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
A6B40_RS07585	COG2003	Belongs to the UPF0758 family
A6B40_RS07600	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A6B40_RS07605	COG0076	glutamate decarboxylase activity
A6B40_RS07610	COG2249	NAD(P)H dehydrogenase (quinone) activity
A6B40_RS07620	COG3062	negative regulation of establishment of protein localization
A6B40_RS07625	COG0243	molybdopterin cofactor binding
A6B40_RS07630	COG0437	4 iron, 4 sulfur cluster binding
A6B40_RS07635	COG0348	domain, Protein
A6B40_RS07640	COG3043	anaerobic respiration
A6B40_RS07645	COG3005	denitrification pathway
A6B40_RS07650	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
A6B40_RS07660	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
A6B40_RS07665	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A6B40_RS07675	COG3005	denitrification pathway
A6B40_RS07690	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A6B40_RS07700	COG3223	Belongs to the PsiE family
A6B40_RS07705	COG0494	nUDIX hydrolase
A6B40_RS07740	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
A6B40_RS07745	COG1803	Methylglyoxal synthase
A6B40_RS07750	COG1289	transmembrane transporter activity
A6B40_RS07755	COG2995	paraquat-inducible protein a
A6B40_RS07760	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
A6B40_RS07790	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
A6B40_RS07790	COG0131	Imidazoleglycerol-phosphate dehydratase
A6B40_RS07800	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
A6B40_RS07810	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
A6B40_RS07815	COG0107	imidazoleglycerol-phosphate synthase activity
A6B40_RS07830	COG0416	fatty acid biosynthetic process
A6B40_RS07840	COG1399	metal-binding, possibly nucleic acid-binding protein
A6B40_RS07845	COG4137	Cytochrome C assembly protein
A6B40_RS07850	COG4536	flavin adenine dinucleotide binding
A6B40_RS07855	COG0733	neurotransmitter:sodium symporter activity
A6B40_RS07865	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
A6B40_RS07870	COG0513	Belongs to the DEAD box helicase family
A6B40_RS07875	COG3691	Protein conserved in bacteria
A6B40_RS07880	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A6B40_RS07885	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A6B40_RS07890	COG3084	Protein conserved in bacteria
A6B40_RS07895	COG0746	molybdenum cofactor guanylyltransferase activity
A6B40_RS07900	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
A6B40_RS07905	COG0676	glucose-6-phosphate 1-epimerase activity
A6B40_RS07915	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
A6B40_RS07920	COG0024	Methionine aminopeptidase
A6B40_RS07930	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
A6B40_RS07935	COG1178	ABC-type Fe3 transport system permease component
A6B40_RS07940	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6B40_RS07945	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A6B40_RS07950	COG2190	(PTS) system
A6B40_RS07955	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A6B40_RS07960	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A6B40_RS07965	COG1621	beta-fructofuranosidase activity
A6B40_RS07980	COG1758	RNA polymerase activity
A6B40_RS07985	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A6B40_RS07995	COG0230	Belongs to the bacterial ribosomal protein bL34 family
A6B40_RS08000	COG0594	ribonuclease P activity
A6B40_RS08010	COG0316	Belongs to the HesB IscA family
A6B40_RS08015	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
A6B40_RS08040	COG1442	glycosyl transferase family 8
A6B40_RS08040	COG1216	Glycosyl transferase, family 2
A6B40_RS08050	COG0562	UDP-galactopyranose mutase
A6B40_RS08055	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A6B40_RS08060	COG1088	dTDP-glucose 4,6-dehydratase activity
A6B40_RS08065	COG3307	-O-antigen
A6B40_RS08080	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A6B40_RS08090	COG1575	Belongs to the MenA family. Type 1 subfamily
A6B40_RS08095	COG1720	tRNA m6t6A37 methyltransferase activity
A6B40_RS08105	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A6B40_RS08125	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A6B40_RS08130	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
A6B40_RS08135	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A6B40_RS08145	COG0745	RESPONSE REGULATOR receiver
A6B40_RS08150	COG2129	metallophosphoesterase
A6B40_RS08155	COG3172	ATPase kinase involved in NAD metabolism
A6B40_RS08160	COG0196	riboflavin kinase activity
A6B40_RS08165	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
A6B40_RS08170	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A6B40_RS08175	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A6B40_RS08180	COG4172	Belongs to the ABC transporter superfamily
A6B40_RS08185	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A6B40_RS08190	COG0601	transmembrane transport
A6B40_RS08195	COG0747	negative chemotaxis
A6B40_RS08210	COG1686	Belongs to the peptidase S11 family
A6B40_RS08225	COG1620	l-lactate permease
A6B40_RS08230	COG0247	lactate metabolic process
A6B40_RS08235	COG1139	Iron-sulfur cluster binding protein
A6B40_RS08240	COG1556	Lactate utilization protein
A6B40_RS08255	COG1561	YicC-like family, N-terminal region
A6B40_RS08260	COG0354	folic acid binding
A6B40_RS08265	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
A6B40_RS08275	COG1129	ABC transporter
A6B40_RS08280	COG1172	Belongs to the binding-protein-dependent transport system permease family
A6B40_RS08285	COG1879	ABC-type sugar transport system periplasmic component
A6B40_RS08290	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A6B40_RS08295	COG1609	Transcriptional regulator
A6B40_RS08300	COG2197	response regulator
A6B40_RS08310	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
A6B40_RS08320	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
A6B40_RS08325	COG1120	ATPase activity
A6B40_RS08350	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
A6B40_RS08355	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
A6B40_RS08365	COG3630	sodium ion export across plasma membrane
A6B40_RS08370	COG1793	dna ligase
A6B40_RS08405	COG0616	signal peptide processing
A6B40_RS08410	COG4608	Belongs to the ABC transporter superfamily
A6B40_RS08420	COG0444	Belongs to the ABC transporter superfamily
A6B40_RS08425	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A6B40_RS08430	COG0601	transmembrane transport
A6B40_RS08435	COG0747	negative chemotaxis
A6B40_RS08440	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
A6B40_RS08445	COG4133	protoheme IX ABC transporter activity
A6B40_RS08450	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A6B40_RS08455	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A6B40_RS08460	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A6B40_RS08470	COG1138	Cytochrome C-type biogenesis protein
A6B40_RS08485	COG0018	arginyl-trna synthetase
A6B40_RS08490	COG3102	Protein conserved in bacteria
A6B40_RS08495	COG3133	Outer membrane lipoprotein
A6B40_RS08515	COG2274	protein secretion by the type I secretion system
A6B40_RS08565	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
A6B40_RS08575	COG0006	proline dipeptidase activity
A6B40_RS08580	COG3030	protein affecting phage T7 exclusion by the F plasmid
A6B40_RS08590	COG1187	pseudouridine synthase activity
A6B40_RS08600	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A6B40_RS08610	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A6B40_RS08615	COG5413	integral membrane protein
A6B40_RS08635	COG4166	transmembrane transport
A6B40_RS08640	COG1254	Belongs to the acylphosphatase family
A6B40_RS08645	COG0308	aminopeptidase N
A6B40_RS08650	COG0748	coenzyme F420 binding
A6B40_RS08655	COG4771	TonB-dependent receptor
A6B40_RS08655	COG1629	transport
A6B40_RS08665	COG0814	amino acid
A6B40_RS08670	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
A6B40_RS08695	COG2195	Cleaves the N-terminal amino acid of tripeptides
A6B40_RS08730	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A6B40_RS08735	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A6B40_RS08740	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A6B40_RS08745	COG1121	(ABC) transporter
A6B40_RS08780	COG3063	Type IV pilus biogenesis stability protein PilW
A6B40_RS08785	COG2183	response to ionizing radiation
A6B40_RS08805	COG0300	oxidoreductase activity
A6B40_RS08810	COG0778	Nitroreductase
A6B40_RS08815	COG0616	signal peptide processing
A6B40_RS08830	COG0477	Major facilitator Superfamily
A6B40_RS08850	COG3978	acetolactate synthase activity
A6B40_RS08865	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
A6B40_RS08870	COG0437	4 iron, 4 sulfur cluster binding
A6B40_RS08875	COG3301	Polysulphide reductase, NrfD
A6B40_RS08880	COG1138	Cytochrome C-type biogenesis protein
A6B40_RS08890	COG4235	cytochrome complex assembly
A6B40_RS08890	COG3088	subunit of a heme lyase
A6B40_RS08900	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A6B40_RS08905	COG1127	ABC transporter
A6B40_RS08910	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A6B40_RS08915	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
A6B40_RS08920	COG2854	intermembrane phospholipid transfer
A6B40_RS08930	COG5007	Belongs to the BolA IbaG family
A6B40_RS08935	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A6B40_RS08940	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
A6B40_RS08945	COG0641	radical SAM
A6B40_RS08950	COG0217	transcriptional regulatory protein
A6B40_RS08955	COG0494	nUDIX hydrolase
A6B40_RS08975	COG2431	L-lysine efflux transmembrane transporter activity
A6B40_RS08985	COG0501	Belongs to the peptidase M48B family
A6B40_RS08990	COG1238	metal cluster binding
A6B40_RS08995	COG2116	formate transmembrane transporter activity
A6B40_RS09000	COG1882	Formate acetyltransferase
A6B40_RS09005	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
A6B40_RS09010	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
A6B40_RS09015	COG0339	signal peptide processing
A6B40_RS09025	COG0077	Prephenate dehydratase
A6B40_RS09025	COG1605	Chorismate mutase
A6B40_RS09030	COG2841	Protein conserved in bacteria
A6B40_RS09035	COG2268	Band 7 protein
A6B40_RS09045	COG2814	Major facilitator Superfamily
A6B40_RS09060	COG1663	tetraacyldisaccharide 4'-kinase activity
A6B40_RS09065	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
A6B40_RS09070	COG0740	serine-type endopeptidase activity
A6B40_RS09075	COG2166	iron-sulfur cluster assembly
A6B40_RS09085	COG2226	methyltransferase
A6B40_RS09100	COG1942	4-Oxalocrotonate Tautomerase
A6B40_RS09105	COG0512	Glutamine amidotransferase of anthranilate synthase
A6B40_RS09110	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A6B40_RS09115	COG0009	L-threonylcarbamoyladenylate synthase
A6B40_RS09120	COG1187	pseudouridine synthase activity
A6B40_RS09125	COG0471	metal ion transport
A6B40_RS09125	COG3273	potassium ion transport
A6B40_RS09155	COG2965	DNA replication, synthesis of RNA primer
A6B40_RS09165	COG0359	binds to the 23S rRNA
A6B40_RS09185	COG4657	Part of a membrane complex involved in electron transport
A6B40_RS09190	COG2878	Part of a membrane complex involved in electron transport
A6B40_RS09195	COG4656	Part of a membrane complex involved in electron transport
A6B40_RS09205	COG2860	membrane
A6B40_RS09210	COG4658	electron transport chain
A6B40_RS09220	COG4660	Part of a membrane complex involved in electron transport
A6B40_RS09225	COG1560	Kdo2-lipid A biosynthetic process
A6B40_RS09245	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
A6B40_RS09255	COG4172	Belongs to the ABC transporter superfamily
A6B40_RS09260	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A6B40_RS09265	COG0601	transmembrane transport
A6B40_RS09270	COG1177	transmembrane transport
A6B40_RS09275	COG1176	ABC-type spermidine putrescine transport system, permease component I
A6B40_RS09280	COG3842	ATPase activity
A6B40_RS09295	COG0210	DNA helicase
A6B40_RS09300	COG2195	Cleaves the N-terminal amino acid of tripeptides
A6B40_RS09315	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
A6B40_RS09320	COG0194	GDP metabolic process
A6B40_RS09325	COG1538	Outer membrane efflux protein
A6B40_RS09335	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A6B40_RS09350	COG3115	cell septum assembly
A6B40_RS09360	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
A6B40_RS09380	COG3118	belongs to the thioredoxin family
A6B40_RS09385	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A6B40_RS09385	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
A6B40_RS09385	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6B40_RS09390	COG1461	Dihydroxyacetone kinase
A6B40_RS09395	COG2376	Dihydroxyacetone kinase
A6B40_RS09400	COG0492	ferredoxin-NADP+ reductase activity
A6B40_RS09410	COG0402	S-adenosylhomocysteine deaminase activity
A6B40_RS09415	COG4143	(ABC) transporter
A6B40_RS09420	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
A6B40_RS09425	COG0617	tRNA 3'-terminal CCA addition
A6B40_RS09430	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
A6B40_RS09440	COG2911	Protein conserved in bacteria
A6B40_RS09450	COG0346	lactoylglutathione lyase activity
A6B40_RS09455	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A6B40_RS09465	COG4771	TonB-dependent receptor
A6B40_RS09465	COG1629	transport
A6B40_RS09475	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A6B40_RS09480	COG2062	phosphohistidine phosphatase, SixA
A6B40_RS09485	COG0469	pyruvate kinase activity
A6B40_RS09490	COG0859	PFAM glycosyl transferase family 9
A6B40_RS09495	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A6B40_RS09500	COG1605	Chorismate mutase
A6B40_RS09500	COG0287	Prephenate dehydrogenase
A6B40_RS09510	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
A6B40_RS09515	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
A6B40_RS09520	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
A6B40_RS09525	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A6B40_RS09535	COG0251	oxidation-reduction process
A6B40_RS09540	COG1022	Amp-dependent synthetase and ligase
A6B40_RS09545	COG3101	peptidyl-lysine hydroxylation
A6B40_RS09555	COG4232	protein-disulfide reductase activity
A6B40_RS09560	COG1126	abc transporter atp-binding protein
A6B40_RS09565	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6B40_RS09570	COG4215	(ABC) transporter
A6B40_RS09575	COG4160	amino acid transport
A6B40_RS09580	COG2255	four-way junction helicase activity
A6B40_RS09585	COG0632	four-way junction helicase activity
A6B40_RS09590	COG1280	lysine exporter protein (LysE YggA)
A6B40_RS09595	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
A6B40_RS09600	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
A6B40_RS09605	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A6B40_RS09610	COG4796	Type ii and iii secretion system protein
A6B40_RS09635	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
A6B40_RS09640	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
A6B40_RS09645	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
A6B40_RS09650	COG0338	D12 class N6 adenine-specific DNA methyltransferase
A6B40_RS09655	COG0733	neurotransmitter:sodium symporter activity
A6B40_RS09660	COG0471	metal ion transport
A6B40_RS09665	COG0126	phosphoglycerate kinase activity
A6B40_RS09670	COG0191	fructose-bisphosphate aldolase activity
A6B40_RS09675	COG4172	Belongs to the ABC transporter superfamily
A6B40_RS09680	COG0778	Nitroreductase
A6B40_RS09690	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A6B40_RS09700	COG3058	Necessary for formate dehydrogenase activity
A6B40_RS09705	COG2864	formate dehydrogenase
A6B40_RS09710	COG0437	4 iron, 4 sulfur cluster binding
A6B40_RS09730	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A6B40_RS09735	COG0215	cysteine-tRNA ligase activity
A6B40_RS09740	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A6B40_RS09760	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
A6B40_RS09765	COG4667	esterase of the alpha-beta hydrolase superfamily
A6B40_RS09775	COG3719	Belongs to the RNase T2 family
A6B40_RS09785	COG1252	NADH dehydrogenase
A6B40_RS09790	COG1840	ABC-type Fe3 transport system, periplasmic component
A6B40_RS09805	COG2252	PERMEase
A6B40_RS09810	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A6B40_RS09815	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A6B40_RS09820	COG1862	Preprotein translocase
A6B40_RS09825	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
A6B40_RS09830	COG2017	converts alpha-aldose to the beta-anomer
A6B40_RS09840	COG1085	galactose-1-phosphate uridylyltransferase
A6B40_RS09845	COG1408	metallophosphoesterase
A6B40_RS09870	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A6B40_RS09895	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A6B40_RS09900	COG1472	Belongs to the glycosyl hydrolase 3 family
A6B40_RS09905	COG0861	Integral membrane protein TerC family
A6B40_RS09925	COG1584	GPR1 FUN34 yaaH family protein
A6B40_RS09930	COG3381	protein complex oligomerization
A6B40_RS09935	COG2221	Nitrite and sulphite reductase 4Fe-4S
A6B40_RS09935	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
A6B40_RS09940	COG0243	molybdopterin cofactor binding
A6B40_RS09945	COG0437	4 iron, 4 sulfur cluster binding
A6B40_RS09950	COG3302	dmso reductase anchor subunit
A6B40_RS09965	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A6B40_RS09970	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A6B40_RS09975	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
A6B40_RS09990	COG3118	belongs to the thioredoxin family
A6B40_RS09995	COG0330	HflC and HflK could
A6B40_RS10000	COG0330	HflC and HflK could
A6B40_RS10015	COG2610	gluconate transmembrane transporter activity
A6B40_RS10020	COG1028	Short-chain dehydrogenase reductase Sdr
A6B40_RS10025	COG0183	Belongs to the thiolase family
A6B40_RS10030	COG2031	fatty acid transporter
A6B40_RS10035	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
A6B40_RS10040	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
A6B40_RS10045	COG0583	DNA-binding transcription factor activity
A6B40_RS10060	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
A6B40_RS10065	COG0301	tRNA thio-modification
A6B40_RS10065	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A6B40_RS10075	COG0205	6-phosphofructokinase activity
A6B40_RS10080	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine