locus-tag	class	description
EJ994_RS00035	COG4974	Belongs to the 'phage' integrase family
EJ994_RS00070	COG4974	Belongs to the 'phage' integrase family
EJ994_RS00175	COG1131	(ABC) transporter
EJ994_RS00230	COG4974	Belongs to the 'phage' integrase family
EJ994_RS00275	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EJ994_RS00285	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
EJ994_RS00300	COG0295	cytidine deaminase activity
EJ994_RS00305	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
EJ994_RS00315	COG2234	aminopeptidase activity
EJ994_RS00320	COG0300	oxidoreductase activity
EJ994_RS00335	COG0662	Cupin 2, conserved barrel domain protein
EJ994_RS00335	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
EJ994_RS00350	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
EJ994_RS00355	COG1524	type I phosphodiesterase nucleotide pyrophosphatase
EJ994_RS00360	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
EJ994_RS00365	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
EJ994_RS00370	COG3738	Protein conserved in bacteria
EJ994_RS00390	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
EJ994_RS00395	COG1262	PFAM Formylglycine-generating sulfatase enzyme
EJ994_RS00400	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
EJ994_RS00405	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EJ994_RS00415	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
EJ994_RS00425	COG0508	dehydrogenase complex catalyzes the overall conversion of
EJ994_RS00425	COG0022	dehydrogenase e1 component
EJ994_RS00430	COG1629	transport
EJ994_RS00430	COG4206	TonB-dependent receptor
EJ994_RS00435	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
EJ994_RS00440	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
EJ994_RS00455	COG1428	Deoxynucleoside kinase
EJ994_RS00460	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
EJ994_RS00485	COG2354	Protein conserved in bacteria
EJ994_RS00500	COG0527	aspartate kinase activity
EJ994_RS00500	COG0460	homoserine dehydrogenase
EJ994_RS00525	COG1959	2 iron, 2 sulfur cluster binding
EJ994_RS00535	COG0175	sulfate reduction
EJ994_RS00540	COG0175	sulfate reduction
EJ994_RS00545	COG2895	sulfate adenylyltransferase (ATP) activity
EJ994_RS00550	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EJ994_RS00555	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EJ994_RS00555	COG1648	precorrin-2 dehydrogenase activity
EJ994_RS00560	COG0492	ferredoxin-NADP+ reductase activity
EJ994_RS00565	COG1410	methionine synthase
EJ994_RS00565	COG0646	methionine synthase
EJ994_RS00580	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
EJ994_RS00615	COG0436	Aminotransferase
EJ994_RS00625	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
EJ994_RS00635	COG1162	GTPase activity
EJ994_RS00640	COG1490	D-aminoacyl-tRNA deacylase activity
EJ994_RS00655	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
EJ994_RS00660	COG0820	rRNA (adenine-C2-)-methyltransferase activity
EJ994_RS00670	COG1595	DNA-templated transcription, initiation
EJ994_RS00690	COG0531	amino acid
EJ994_RS00695	COG0358	DNA primase activity
EJ994_RS00705	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
EJ994_RS00775	COG0218	Necessary for normal cell division and for the maintenance of normal septation
EJ994_RS00785	COG2001	Belongs to the MraZ family
EJ994_RS00790	COG0275	rRNA processing
EJ994_RS00800	COG0768	penicillin binding
EJ994_RS00805	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
EJ994_RS00810	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EJ994_RS00815	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
EJ994_RS00820	COG0772	Belongs to the SEDS family
EJ994_RS00825	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
EJ994_RS00830	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EJ994_RS00845	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
EJ994_RS00850	COG1610	YqeY-like protein
EJ994_RS00860	COG1929	Belongs to the glycerate kinase type-1 family
EJ994_RS00865	COG0492	ferredoxin-NADP+ reductase activity
EJ994_RS00870	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
EJ994_RS00890	COG4628	conserved protein (DUF2132)
EJ994_RS00895	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EJ994_RS00900	COG1185	polyribonucleotide nucleotidyltransferase activity
EJ994_RS00905	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
EJ994_RS00915	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
EJ994_RS00920	COG0191	fructose-bisphosphate aldolase activity
EJ994_RS00930	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EJ994_RS00940	COG2226	methyltransferase
EJ994_RS00945	COG0569	domain protein
EJ994_RS00950	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EJ994_RS00960	COG3119	arylsulfatase activity
EJ994_RS00965	COG0436	Aminotransferase
EJ994_RS00970	COG3239	Fatty acid desaturase
EJ994_RS00975	COG0357	Ribosomal RNA small subunit methyltransferase G
EJ994_RS00990	COG1012	belongs to the aldehyde dehydrogenase family
EJ994_RS00995	COG2967	ApaG domain
EJ994_RS01010	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
EJ994_RS01015	COG1805	sodium ion transport
EJ994_RS01025	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
EJ994_RS01030	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
EJ994_RS01045	COG1477	protein flavinylation
EJ994_RS01050	COG2226	methyltransferase
EJ994_RS01060	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
EJ994_RS01065	COG0666	response to abiotic stimulus
EJ994_RS01125	COG0671	phosphoesterase, PA-phosphatase related
EJ994_RS01140	COG3844	kynureninase activity
EJ994_RS01170	COG0740	serine-type endopeptidase activity
EJ994_RS01220	COG3046	protein related to deoxyribodipyrimidine photolyase
EJ994_RS01225	COG0415	Belongs to the DNA photolyase family
EJ994_RS01240	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EJ994_RS01255	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
EJ994_RS01260	COG1663	tetraacyldisaccharide 4'-kinase activity
EJ994_RS01275	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
EJ994_RS01295	COG1595	DNA-templated transcription, initiation
EJ994_RS01300	COG0812	UDP-N-acetylmuramate dehydrogenase activity
EJ994_RS01305	COG0436	Aminotransferase
EJ994_RS01310	COG0750	zinc metalloprotease
EJ994_RS01320	COG0525	valine-tRNA ligase activity
EJ994_RS01350	COG0688	phosphatidylethanolamine metabolic process
EJ994_RS01355	COG4589	Belongs to the CDS family
EJ994_RS01365	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EJ994_RS01370	COG0799	negative regulation of ribosome biogenesis
EJ994_RS01385	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
EJ994_RS01390	COG1051	belongs to the nudix hydrolase family
EJ994_RS01400	COG2201	protein-glutamate methylesterase activity
EJ994_RS01415	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
EJ994_RS01420	COG1181	Belongs to the D-alanine--D-alanine ligase family
EJ994_RS01425	COG2815	serine threonine protein kinase
EJ994_RS01425	COG0515	serine threonine protein kinase
EJ994_RS01430	COG0564	pseudouridine synthase activity
EJ994_RS01435	COG3022	response to hydroperoxide
EJ994_RS01460	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
EJ994_RS01475	COG0702	epimerase
EJ994_RS01485	COG0159	tryptophan synthase activity
EJ994_RS01495	COG0133	tryptophan synthase activity
EJ994_RS01500	COG0135	phosphoribosylanthranilate isomerase activity
EJ994_RS01505	COG0134	indole-3-glycerol-phosphate synthase activity
EJ994_RS01510	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EJ994_RS01515	COG0512	Glutamine amidotransferase of anthranilate synthase
EJ994_RS01520	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
EJ994_RS01525	COG2353	YceI-like domain
EJ994_RS01530	COG0778	Nitroreductase
EJ994_RS01535	COG1846	Transcriptional regulator
EJ994_RS01540	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EJ994_RS01560	COG1115	amino acid carrier protein
EJ994_RS01570	COG1960	acyl-CoA dehydrogenase activity
EJ994_RS01575	COG0828	Belongs to the bacterial ribosomal protein bS21 family
EJ994_RS01580	COG4974	Belongs to the 'phage' integrase family
EJ994_RS01630	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
EJ994_RS01635	COG0081	regulation of translation
EJ994_RS01640	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
EJ994_RS01645	COG0222	ribosome binding
EJ994_RS01650	COG0085	RNA polymerase activity
EJ994_RS01655	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
EJ994_RS01665	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
EJ994_RS01705	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
EJ994_RS01715	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EJ994_RS01720	COG1482	cell wall glycoprotein biosynthetic process
EJ994_RS01740	COG0561	phosphatase activity
EJ994_RS01770	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
EJ994_RS01805	COG2258	MOSC domain
EJ994_RS01815	COG0326	Molecular chaperone. Has ATPase activity
EJ994_RS01830	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EJ994_RS01845	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
EJ994_RS01850	COG0508	dehydrogenase complex catalyzes the overall conversion of
EJ994_RS01865	COG0179	Fumarylacetoacetate (FAA) hydrolase
EJ994_RS01875	COG1546	Belongs to the CinA family
EJ994_RS01875	COG1058	Belongs to the CinA family
EJ994_RS01880	COG0227	Belongs to the bacterial ribosomal protein bL28 family
EJ994_RS01885	COG0267	Belongs to the bacterial ribosomal protein bL33 family
EJ994_RS01895	COG0552	protein localization to endoplasmic reticulum
EJ994_RS01905	COG0154	amidase activity
EJ994_RS01940	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EJ994_RS01965	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
EJ994_RS01980	COG0518	GMP synthase (glutamine-hydrolyzing) activity
EJ994_RS01980	COG0519	Catalyzes the synthesis of GMP from XMP
EJ994_RS02005	COG3530	Putative quorum-sensing-regulated virulence factor
EJ994_RS02010	COG0504	CTP synthase activity
EJ994_RS02015	COG0706	membrane insertase activity
EJ994_RS02025	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
EJ994_RS02030	COG0482	sulfurtransferase activity
EJ994_RS02045	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EJ994_RS02060	COG1741	Belongs to the pirin family
EJ994_RS02075	COG0714	Associated with various cellular activities
EJ994_RS02115	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EJ994_RS02140	COG1473	amidohydrolase
EJ994_RS02145	COG1252	NADH dehydrogenase
EJ994_RS02150	COG0366	Alpha amylase catalytic
EJ994_RS02160	COG4974	Belongs to the 'phage' integrase family
EJ994_RS02175	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
EJ994_RS02180	COG2133	pyrroloquinoline quinone binding
EJ994_RS02190	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EJ994_RS02200	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EJ994_RS02210	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
EJ994_RS02225	COG2270	Major facilitator Superfamily
EJ994_RS02245	COG1595	DNA-templated transcription, initiation
EJ994_RS02255	COG5492	domain, Protein
EJ994_RS02260	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
EJ994_RS02265	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
EJ994_RS02270	COG2823	Periplasmic or secreted lipoprotein
EJ994_RS02270	COG1652	LysM domain
EJ994_RS02280	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
EJ994_RS02285	COG0540	Belongs to the ATCase OTCase family
EJ994_RS02295	COG1234	tRNA 3'-trailer cleavage
EJ994_RS02300	COG0259	pyridoxamine-phosphate oxidase activity
EJ994_RS02310	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
EJ994_RS02340	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
EJ994_RS02360	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
EJ994_RS02370	COG0473	3-isopropylmalate dehydrogenase activity
EJ994_RS02410	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EJ994_RS02420	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
EJ994_RS02430	COG1454	alcohol dehydrogenase
EJ994_RS02445	COG0217	transcriptional regulatory protein
EJ994_RS02450	COG2154	pterin-4-alpha-carbinolamine dehydratase
EJ994_RS02460	COG2066	Belongs to the glutaminase family
EJ994_RS02465	COG0404	The glycine cleavage system catalyzes the degradation of glycine
EJ994_RS02470	COG0006	proline dipeptidase activity
EJ994_RS02475	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
EJ994_RS02480	COG0083	homoserine kinase activity
EJ994_RS02485	COG0527	aspartate kinase activity
EJ994_RS02485	COG0460	homoserine dehydrogenase
EJ994_RS02490	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
EJ994_RS02500	COG0542	response to heat
EJ994_RS02520	COG0183	Belongs to the thiolase family
EJ994_RS02565	COG2115	Belongs to the xylose isomerase family
EJ994_RS02585	COG1082	Xylose isomerase domain protein TIM barrel
EJ994_RS02595	COG3119	arylsulfatase activity
EJ994_RS02605	COG0657	acetylesterase activity
EJ994_RS02605	COG2755	lipolytic protein G-D-S-L family
EJ994_RS02630	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
EJ994_RS02635	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
EJ994_RS02640	COG2610	gluconate transmembrane transporter activity
EJ994_RS02645	COG1331	Highly conserved protein containing a thioredoxin domain
EJ994_RS02650	COG3119	arylsulfatase activity
EJ994_RS02655	COG1262	PFAM Formylglycine-generating sulfatase enzyme
EJ994_RS02660	COG0492	ferredoxin-NADP+ reductase activity
EJ994_RS02670	COG0156	8-amino-7-oxononanoate synthase activity
EJ994_RS02675	COG4948	Mandelate Racemase Muconate Lactonizing
EJ994_RS02715	COG3422	double-strand break repair
EJ994_RS02730	COG3781	membrane
EJ994_RS02740	COG0494	nUDIX hydrolase
EJ994_RS02745	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EJ994_RS02770	COG0783	Belongs to the Dps family
EJ994_RS02790	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
EJ994_RS02800	COG2808	Putative FMN-binding domain
EJ994_RS02805	COG2267	carboxylic ester hydrolase activity
EJ994_RS02830	COG4946	Tricorn protease homolog
EJ994_RS02830	COG1506	peptidase
EJ994_RS02830	COG0823	Involved in the tonB-independent uptake of proteins
EJ994_RS02850	COG3340	Belongs to the peptidase S51 family
EJ994_RS02855	COG0513	Belongs to the DEAD box helicase family
EJ994_RS02865	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
EJ994_RS02880	COG3275	phosphorelay sensor kinase activity
EJ994_RS02910	COG3279	Response regulator of the LytR AlgR family
EJ994_RS02985	COG1073	alpha beta
EJ994_RS03030	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
EJ994_RS03085	COG2124	cytochrome p450
EJ994_RS03190	COG3387	PFAM Glycoside hydrolase 15-related
EJ994_RS03200	COG1960	acyl-CoA dehydrogenase activity
EJ994_RS03205	COG0183	Belongs to the thiolase family
EJ994_RS03215	COG1250	3-hydroxyacyl-CoA dehydrogenase
EJ994_RS03215	COG1024	Enoyl-CoA hydratase
EJ994_RS03240	COG4771	TonB-dependent receptor
EJ994_RS03245	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EJ994_RS03245	COG0047	phosphoribosylformylglycinamidine synthase activity
EJ994_RS03275	COG2852	Protein conserved in bacteria
EJ994_RS03280	COG1473	amidohydrolase
EJ994_RS03290	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EJ994_RS03290	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
EJ994_RS03310	COG1595	DNA-templated transcription, initiation
EJ994_RS03315	COG1132	(ABC) transporter
EJ994_RS03320	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EJ994_RS03335	COG0254	rRNA binding
EJ994_RS03345	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EJ994_RS03360	COG0741	lytic transglycosylase activity
EJ994_RS03370	COG0230	Belongs to the bacterial ribosomal protein bL34 family
EJ994_RS03405	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
EJ994_RS03410	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
EJ994_RS03415	COG0363	glucosamine-6-phosphate deaminase activity
EJ994_RS03435	COG1120	ATPase activity
EJ994_RS03440	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EJ994_RS03450	COG4206	TonB-dependent receptor
EJ994_RS03490	COG0668	transmembrane transport
EJ994_RS03505	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
EJ994_RS03525	COG0366	Alpha amylase catalytic
EJ994_RS03535	COG0513	Belongs to the DEAD box helicase family
EJ994_RS03545	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
EJ994_RS03570	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EJ994_RS03575	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
EJ994_RS03585	COG1295	ribonuclease BN
EJ994_RS03595	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
EJ994_RS03600	COG3279	Response regulator of the LytR AlgR family
EJ994_RS03605	COG0360	Binds together with S18 to 16S ribosomal RNA
EJ994_RS03610	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
EJ994_RS03615	COG0359	binds to the 23S rRNA
EJ994_RS03625	COG0124	histidyl-tRNA synthetase
EJ994_RS03635	COG1363	Peptidase, m42
EJ994_RS03670	COG0335	large ribosomal subunit rRNA binding
EJ994_RS03675	COG0336	Belongs to the RNA methyltransferase TrmD family
EJ994_RS03680	COG0456	acetyltransferase
EJ994_RS03700	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
EJ994_RS03705	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EJ994_RS03710	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
EJ994_RS03725	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EJ994_RS03730	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EJ994_RS03740	COG1739	Uncharacterized protein family UPF0029
EJ994_RS03750	COG1011	Hydrolase
EJ994_RS03755	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EJ994_RS03755	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EJ994_RS03765	COG2890	protein-(glutamine-N5) methyltransferase activity
EJ994_RS03770	COG1611	Belongs to the LOG family
EJ994_RS03775	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
EJ994_RS03815	COG2423	ornithine cyclodeaminase activity
EJ994_RS03850	COG0737	Belongs to the 5'-nucleotidase family
EJ994_RS03855	COG0737	Belongs to the 5'-nucleotidase family
EJ994_RS03855	COG1525	nuclease
EJ994_RS03855	COG4085	toxin activity
EJ994_RS03865	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EJ994_RS03890	COG0497	DNA recombination
EJ994_RS03895	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
EJ994_RS03900	COG0463	Glycosyl transferase, family 2
EJ994_RS03900	COG1216	Glycosyl transferase, family 2
EJ994_RS03910	COG0237	dephospho-CoA kinase activity
EJ994_RS03925	COG3265	gluconokinase activity
EJ994_RS03930	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
EJ994_RS03935	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EJ994_RS03940	COG2176	DNA-directed DNA polymerase activity
EJ994_RS03945	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
EJ994_RS03955	COG1250	3-hydroxyacyl-CoA dehydrogenase
EJ994_RS03965	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
EJ994_RS03970	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
EJ994_RS03995	COG0542	response to heat
EJ994_RS04010	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
EJ994_RS04030	COG3279	Response regulator of the LytR AlgR family
EJ994_RS04055	COG0300	oxidoreductase activity
EJ994_RS04065	COG0488	(ABC) transporter
EJ994_RS04080	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
EJ994_RS04095	COG0473	3-isopropylmalate dehydrogenase activity
EJ994_RS04100	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EJ994_RS04110	COG0697	spore germination
EJ994_RS04120	COG0564	pseudouridine synthase activity
EJ994_RS04125	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
EJ994_RS04130	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
EJ994_RS04195	COG0405	Gamma-glutamyltransferase
EJ994_RS04205	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EJ994_RS04225	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EJ994_RS04235	COG0277	FAD linked oxidase domain protein
EJ994_RS04235	COG0247	lactate metabolic process
EJ994_RS04245	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
EJ994_RS04250	COG1301	dicarboxylic acid transport
EJ994_RS04255	COG0189	ligase activity
EJ994_RS04275	COG3011	Protein conserved in bacteria
EJ994_RS04305	COG1472	Belongs to the glycosyl hydrolase 3 family
EJ994_RS04325	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
EJ994_RS04340	COG0813	purine-nucleoside phosphorylase activity
EJ994_RS04360	COG0022	dehydrogenase e1 component
EJ994_RS04375	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EJ994_RS04390	COG1028	Short-chain dehydrogenase reductase Sdr
EJ994_RS04395	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EJ994_RS04400	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EJ994_RS04405	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EJ994_RS04505	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
EJ994_RS04530	COG2205	protein histidine kinase activity
EJ994_RS04530	COG0745	RESPONSE REGULATOR receiver
EJ994_RS04530	COG3292	Two component regulator propeller
EJ994_RS04550	COG3279	Response regulator of the LytR AlgR family
EJ994_RS04555	COG3275	phosphorelay sensor kinase activity
EJ994_RS04560	COG1131	(ABC) transporter
EJ994_RS04585	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
EJ994_RS04590	COG1187	pseudouridine synthase activity
EJ994_RS04595	COG0697	spore germination
EJ994_RS04605	COG1858	cytochrome C peroxidase
EJ994_RS04640	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
EJ994_RS04675	COG1741	Belongs to the pirin family
EJ994_RS04700	COG2357	RelA SpoT domain protein
EJ994_RS04775	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EJ994_RS04790	COG1215	transferase activity, transferring glycosyl groups
EJ994_RS04800	COG0745	RESPONSE REGULATOR receiver
EJ994_RS04815	COG1607	acyl-coa hydrolase
EJ994_RS04835	COG1045	serine acetyltransferase
EJ994_RS04900	COG0783	Belongs to the Dps family
EJ994_RS04905	COG0598	Magnesium transport protein CorA
EJ994_RS04910	COG0101	tRNA pseudouridine synthase activity
EJ994_RS04925	COG0745	RESPONSE REGULATOR receiver
EJ994_RS04930	COG5002	protein histidine kinase activity
EJ994_RS04950	COG2311	Membrane
EJ994_RS04955	COG0140	phosphoribosyl-ATP diphosphatase activity
EJ994_RS04955	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
EJ994_RS04960	COG0107	imidazoleglycerol-phosphate synthase activity
EJ994_RS04970	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
EJ994_RS04985	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
EJ994_RS04985	COG0131	Imidazoleglycerol-phosphate dehydratase
EJ994_RS04990	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EJ994_RS04995	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
EJ994_RS05000	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
EJ994_RS05015	COG0393	Putative heavy-metal-binding
EJ994_RS05020	COG1028	Short-chain dehydrogenase reductase Sdr
EJ994_RS05025	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
EJ994_RS05030	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EJ994_RS05035	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EJ994_RS05040	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EJ994_RS05045	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EJ994_RS05045	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
EJ994_RS05050	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EJ994_RS05055	COG1078	dGTPase activity
EJ994_RS05060	COG2204	response regulator
EJ994_RS05065	COG0802	atpase or kinase
EJ994_RS05090	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
EJ994_RS05105	COG1522	sequence-specific DNA binding
EJ994_RS05125	COG0861	Integral membrane protein TerC family
EJ994_RS05150	COG0012	GTP binding
EJ994_RS05155	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
EJ994_RS05165	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
EJ994_RS05170	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EJ994_RS05225	COG0302	gtp cyclohydrolase
EJ994_RS05230	COG1136	(ABC) transporter
EJ994_RS05245	COG1858	cytochrome C peroxidase
EJ994_RS05260	COG0673	inositol 2-dehydrogenase activity
EJ994_RS05285	COG1233	COG1233 Phytoene dehydrogenase and related
EJ994_RS05295	COG2234	aminopeptidase activity
EJ994_RS05305	COG3852	Histidine kinase
EJ994_RS05310	COG2205	protein histidine kinase activity
EJ994_RS05315	COG2205	protein histidine kinase activity
EJ994_RS05320	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
EJ994_RS05325	COG0626	cystathionine gamma-synthase activity
EJ994_RS05330	COG0534	Mate efflux family protein
EJ994_RS05340	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EJ994_RS05340	COG1333	cytochrome c biogenesis protein
EJ994_RS05355	COG0424	maF-like protein
EJ994_RS05380	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
EJ994_RS05400	COG0415	Belongs to the DNA photolyase family
EJ994_RS05410	COG0415	Belongs to the DNA photolyase family
EJ994_RS05415	COG1473	amidohydrolase
EJ994_RS05455	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
EJ994_RS05475	COG0514	ATP-dependent DNA helicase (RecQ)
EJ994_RS05480	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EJ994_RS05490	COG1678	Uncharacterized ACR, COG1678
EJ994_RS05495	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EJ994_RS05525	COG2267	carboxylic ester hydrolase activity
EJ994_RS05535	COG1228	amidohydrolase
EJ994_RS05540	COG0604	alcohol dehydrogenase
EJ994_RS05555	COG0180	Tryptophanyl-tRNA synthetase
EJ994_RS05620	COG3279	Response regulator of the LytR AlgR family
EJ994_RS05625	COG3275	phosphorelay sensor kinase activity
EJ994_RS05635	COG1131	(ABC) transporter
EJ994_RS05640	COG3275	phosphorelay sensor kinase activity
EJ994_RS05645	COG3279	Response regulator of the LytR AlgR family
EJ994_RS05680	COG2207	Transcriptional regulator
EJ994_RS05680	COG1917	Cupin 2, conserved barrel domain protein
EJ994_RS05690	COG1611	Belongs to the LOG family
EJ994_RS05700	COG0022	dehydrogenase e1 component
EJ994_RS05705	COG0612	Peptidase, M16
EJ994_RS05710	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EJ994_RS05740	COG0009	L-threonylcarbamoyladenylate synthase
EJ994_RS05755	COG1473	amidohydrolase
EJ994_RS05760	COG0069	glutamate synthase activity
EJ994_RS05790	COG0308	aminopeptidase N
EJ994_RS05795	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
EJ994_RS05800	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
EJ994_RS05805	COG0066	3-isopropylmalate dehydratase activity
EJ994_RS05815	COG0473	3-isopropylmalate dehydrogenase activity
EJ994_RS05825	COG1012	belongs to the aldehyde dehydrogenase family
EJ994_RS05830	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
EJ994_RS05835	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
EJ994_RS05840	COG0440	acetolactate synthase activity
EJ994_RS05855	COG0028	Belongs to the TPP enzyme family
EJ994_RS05860	COG0129	dihydroxy-acid dehydratase activity
EJ994_RS05870	COG1984	allophanate hydrolase subunit 2
EJ994_RS05875	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
EJ994_RS05905	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EJ994_RS05940	COG0606	chelatase, subunit chli
EJ994_RS05950	COG4232	protein-disulfide reductase activity
EJ994_RS05955	COG0037	tRNA processing
EJ994_RS05960	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
EJ994_RS05985	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EJ994_RS05995	COG0626	cystathionine gamma-synthase activity
EJ994_RS06000	COG1757	Na H antiporter
EJ994_RS06005	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
EJ994_RS06015	COG1674	ftsk spoiiie
EJ994_RS06030	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EJ994_RS06030	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EJ994_RS06035	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EJ994_RS06050	COG1216	Glycosyl transferase, family 2
EJ994_RS06050	COG1442	glycosyl transferase family 8
EJ994_RS06060	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
EJ994_RS06090	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EJ994_RS06095	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
EJ994_RS06100	COG1595	DNA-templated transcription, initiation
EJ994_RS06105	COG1595	DNA-templated transcription, initiation
EJ994_RS06110	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EJ994_RS06120	COG0564	pseudouridine synthase activity
EJ994_RS06155	COG0156	8-amino-7-oxononanoate synthase activity
EJ994_RS06170	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
EJ994_RS06200	COG2308	Evidence 4 Homologs of previously reported genes of
EJ994_RS06250	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
EJ994_RS06255	COG0488	(ABC) transporter
EJ994_RS06265	COG0673	inositol 2-dehydrogenase activity
EJ994_RS06270	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EJ994_RS06290	COG4771	TonB-dependent receptor
EJ994_RS06310	COG1266	CAAX protease self-immunity
EJ994_RS06320	COG1028	Short-chain dehydrogenase reductase Sdr
EJ994_RS06330	COG0784	Response regulator, receiver
EJ994_RS06335	COG1575	Belongs to the MenA family. Type 1 subfamily
EJ994_RS06345	COG2996	Protein conserved in bacteria
EJ994_RS06355	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
EJ994_RS06360	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
EJ994_RS06385	COG0443	Heat shock 70 kDa protein
EJ994_RS06390	COG1760	l-serine dehydratase
EJ994_RS06395	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
EJ994_RS06400	COG1702	phosphate starvation-inducible protein PhoH
EJ994_RS06405	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
EJ994_RS06410	COG0592	DNA-directed DNA polymerase activity
EJ994_RS06425	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
EJ994_RS06450	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EJ994_RS06465	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EJ994_RS06480	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
EJ994_RS06500	COG0728	peptidoglycan biosynthetic process
EJ994_RS06505	COG0438	transferase activity, transferring glycosyl groups
EJ994_RS06520	COG0438	transferase activity, transferring glycosyl groups
EJ994_RS06525	COG0367	asparagine synthase
EJ994_RS06540	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EJ994_RS06570	COG1216	Glycosyl transferase, family 2
EJ994_RS06570	COG0463	Glycosyl transferase, family 2
EJ994_RS06615	COG1215	transferase activity, transferring glycosyl groups
EJ994_RS06620	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EJ994_RS06650	COG0438	transferase activity, transferring glycosyl groups
EJ994_RS06655	COG1472	Belongs to the glycosyl hydrolase 3 family
EJ994_RS06665	COG2181	nitrate reductase activity
EJ994_RS06665	COG0247	lactate metabolic process
EJ994_RS06670	COG0247	lactate metabolic process
EJ994_RS06670	COG2181	nitrate reductase activity
EJ994_RS06680	COG0860	N-Acetylmuramoyl-L-alanine amidase
EJ994_RS06690	COG0251	oxidation-reduction process
EJ994_RS06705	COG0205	6-phosphofructokinase activity
EJ994_RS06715	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
EJ994_RS06720	COG1385	rRNA (uridine-N3-)-methyltransferase activity
EJ994_RS06745	COG1629	transport
EJ994_RS06750	COG0702	epimerase
EJ994_RS06775	COG2133	pyrroloquinoline quinone binding
EJ994_RS06780	COG2010	Cytochrome c
EJ994_RS06785	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
EJ994_RS06790	COG1349	DNA-binding transcription factor activity
EJ994_RS06795	COG0363	glucosamine-6-phosphate deaminase activity
EJ994_RS06800	COG1649	PFAM Uncharacterised BCR, COG1649
EJ994_RS06805	COG2211	Major facilitator Superfamily
EJ994_RS06810	COG1472	Belongs to the glycosyl hydrolase 3 family
EJ994_RS06815	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
EJ994_RS06825	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EJ994_RS06830	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EJ994_RS06835	COG2814	Major facilitator Superfamily
EJ994_RS06840	COG0572	uridine kinase
EJ994_RS06850	COG1192	Involved in chromosome partitioning
EJ994_RS06855	COG1475	DNA binding
EJ994_RS06865	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
EJ994_RS06870	COG0681	Belongs to the peptidase S26 family
EJ994_RS06900	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
EJ994_RS06910	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
EJ994_RS06920	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EJ994_RS06935	COG0105	UTP biosynthetic process
EJ994_RS06945	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
EJ994_RS06955	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EJ994_RS06960	COG2195	Cleaves the N-terminal amino acid of tripeptides
EJ994_RS06990	COG0303	'Molybdopterin
EJ994_RS07000	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EJ994_RS07005	COG0315	cyclic pyranopterin monophosphate synthase activity
EJ994_RS07005	COG0746	molybdenum cofactor guanylyltransferase activity
EJ994_RS07010	COG0315	cyclic pyranopterin monophosphate synthase activity
EJ994_RS07015	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
EJ994_RS07020	COG0314	molybdopterin synthase activity
EJ994_RS07045	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EJ994_RS07050	COG0501	Belongs to the peptidase M48B family
EJ994_RS07055	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EJ994_RS07060	COG0735	belongs to the Fur family
EJ994_RS07065	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
EJ994_RS07075	COG0673	inositol 2-dehydrogenase activity
EJ994_RS07095	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EJ994_RS07115	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
EJ994_RS07130	COG2095	MarC family integral membrane protein
EJ994_RS07140	COG1418	mRNA catabolic process
EJ994_RS07160	COG0739	heme binding
EJ994_RS07175	COG1104	cysteine desulfurase activity
EJ994_RS07205	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EJ994_RS07210	COG0668	transmembrane transport
EJ994_RS07215	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
EJ994_RS07235	COG0116	Belongs to the methyltransferase superfamily
EJ994_RS07250	COG1272	protein, Hemolysin III
EJ994_RS07255	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
EJ994_RS07285	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
EJ994_RS07290	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
EJ994_RS07295	COG0291	Belongs to the bacterial ribosomal protein bL35 family
EJ994_RS07300	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
EJ994_RS07310	COG0561	phosphatase activity
EJ994_RS07325	COG0305	Participates in initiation and elongation during chromosome replication
EJ994_RS07330	COG0825	malonyl-CoA metabolic process
EJ994_RS07345	COG0343	queuine tRNA-ribosyltransferase activity
EJ994_RS07365	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
EJ994_RS07370	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
EJ994_RS07380	COG2197	response regulator
EJ994_RS07430	COG3279	Response regulator of the LytR AlgR family
EJ994_RS07440	COG4251	negative regulation of phosphorylation
EJ994_RS07450	COG4251	negative regulation of phosphorylation
EJ994_RS07460	COG0784	Response regulator, receiver
EJ994_RS07465	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EJ994_RS07470	COG3938	Belongs to the proline racemase family
EJ994_RS07485	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EJ994_RS07490	COG2207	Transcriptional regulator
EJ994_RS07530	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EJ994_RS07540	COG0714	Associated with various cellular activities
EJ994_RS07565	COG1187	pseudouridine synthase activity
EJ994_RS07575	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
EJ994_RS07580	COG1619	proteins homologs of microcin C7 resistance protein MccF
EJ994_RS07585	COG0514	ATP-dependent DNA helicase (RecQ)
EJ994_RS07590	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
EJ994_RS07590	COG0517	IMP dehydrogenase activity
EJ994_RS07595	COG0805	protein transport
EJ994_RS07605	COG1137	ATPase activity
EJ994_RS07655	COG0488	(ABC) transporter
EJ994_RS07680	COG0653	protein targeting
EJ994_RS07705	COG0513	Belongs to the DEAD box helicase family
EJ994_RS07715	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
EJ994_RS07740	COG1595	DNA-templated transcription, initiation
EJ994_RS07755	COG0251	oxidation-reduction process
EJ994_RS07765	COG0577	efflux transmembrane transporter activity
EJ994_RS07765	COG1136	(ABC) transporter
EJ994_RS07770	COG4181	ATPase activity
EJ994_RS07790	COG4529	Protein conserved in bacteria
EJ994_RS07805	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EJ994_RS07825	COG1595	DNA-templated transcription, initiation
EJ994_RS07830	COG2017	converts alpha-aldose to the beta-anomer
EJ994_RS07845	COG0463	Glycosyl transferase, family 2
EJ994_RS07855	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
EJ994_RS07860	COG0671	phosphoesterase, PA-phosphatase related
EJ994_RS07875	COG3956	TIGRFAM MazG family protein
EJ994_RS07890	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
EJ994_RS07915	COG0242	peptide deformylase activity
EJ994_RS07925	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
EJ994_RS07930	COG2171	N-acyltransferase activity
EJ994_RS07950	COG0009	L-threonylcarbamoyladenylate synthase
EJ994_RS07955	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
EJ994_RS07955	COG0617	tRNA 3'-terminal CCA addition
EJ994_RS07955	COG0517	IMP dehydrogenase activity
EJ994_RS07980	COG1131	(ABC) transporter
EJ994_RS08000	COG0556	nucleotide-excision repair
EJ994_RS08035	COG0045	succinate-CoA ligase (ADP-forming) activity
EJ994_RS08045	COG0019	diaminopimelate decarboxylase activity
EJ994_RS08055	COG0516	GMP reductase activity
EJ994_RS08055	COG0517	IMP dehydrogenase activity
EJ994_RS08070	COG4772	TonB-dependent receptor
EJ994_RS08095	COG1528	Iron-storage protein
EJ994_RS08125	COG0167	dihydroorotate dehydrogenase activity
EJ994_RS08135	COG2195	Cleaves the N-terminal amino acid of tripeptides
EJ994_RS08140	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
EJ994_RS08150	COG1862	Preprotein translocase
EJ994_RS08160	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EJ994_RS08165	COG1132	(ABC) transporter
EJ994_RS08185	COG0385	Bile acid
EJ994_RS08200	COG2318	DinB family
EJ994_RS08205	COG0450	alkyl hydroperoxide reductase
EJ994_RS08210	COG1278	Cold shock
EJ994_RS08215	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EJ994_RS08225	COG2326	polyphosphate kinase activity
EJ994_RS08235	COG2204	response regulator
EJ994_RS08245	COG3264	Mechanosensitive ion channel
EJ994_RS08245	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
EJ994_RS08250	COG1668	transmembrane transport
EJ994_RS08255	COG4152	abc transporter atp-binding protein
EJ994_RS08260	COG0484	heat shock protein binding
EJ994_RS08265	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
EJ994_RS08270	COG1090	epimerase
EJ994_RS08275	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
EJ994_RS08275	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EJ994_RS08285	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EJ994_RS08300	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
EJ994_RS08310	COG0004	ammonium transporteR
EJ994_RS08335	COG1522	sequence-specific DNA binding
EJ994_RS08345	COG0788	formyltetrahydrofolate deformylase activity
EJ994_RS08360	COG1629	transport
EJ994_RS08385	COG0284	orotidine-5'-phosphate decarboxylase activity
EJ994_RS08390	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
EJ994_RS08410	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EJ994_RS08420	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
EJ994_RS08430	COG0174	glutamine synthetase
EJ994_RS08450	COG0739	heme binding
EJ994_RS08460	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EJ994_RS08500	COG2391	methyltransferase activity
EJ994_RS08530	COG2264	protein methyltransferase activity
EJ994_RS08535	COG0149	triose-phosphate isomerase activity
EJ994_RS08550	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
EJ994_RS08555	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
EJ994_RS08565	COG1132	(ABC) transporter
EJ994_RS08570	COG0101	tRNA pseudouridine synthase activity
EJ994_RS08600	COG0268	Binds directly to 16S ribosomal RNA
EJ994_RS08615	COG0442	prolyl-tRNA aminoacylation
EJ994_RS08640	COG0302	gtp cyclohydrolase
EJ994_RS08645	COG0215	cysteine-tRNA ligase activity
EJ994_RS08650	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
EJ994_RS08655	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
EJ994_RS08670	COG1119	ATPase activity
EJ994_RS08675	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EJ994_RS08700	COG0187	DNA topoisomerase II activity
EJ994_RS08705	COG0367	asparagine synthase
EJ994_RS08750	COG2884	Cell division ATP-binding protein ftsE
EJ994_RS08760	COG4948	Mandelate Racemase Muconate Lactonizing
EJ994_RS08810	COG1217	gtp-binding protein TYPA
EJ994_RS08830	COG3275	phosphorelay sensor kinase activity
EJ994_RS08835	COG3279	Response regulator of the LytR AlgR family
EJ994_RS08850	COG2877	3-deoxy-8-phosphooctulonate synthase activity
EJ994_RS08885	COG0322	excinuclease ABC activity
EJ994_RS08895	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EJ994_RS08895	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EJ994_RS08930	COG3876	Protein conserved in bacteria
EJ994_RS08955	COG0602	queuosine metabolic process
EJ994_RS08960	COG0433	COG0433 Predicted ATPase
EJ994_RS08975	COG2267	carboxylic ester hydrolase activity
EJ994_RS08985	COG0667	Aldo Keto reductase
EJ994_RS09000	COG3590	peptidase
EJ994_RS09005	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
EJ994_RS09010	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
EJ994_RS09050	COG0018	arginyl-trna synthetase
EJ994_RS09060	COG0702	epimerase
EJ994_RS09100	COG0148	phosphopyruvate hydratase activity
EJ994_RS09105	COG0505	Belongs to the CarA family
EJ994_RS09110	COG0203	ribosomal protein L17
EJ994_RS09115	COG0202	RNA polymerase activity
EJ994_RS09120	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
EJ994_RS09125	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
EJ994_RS09130	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
EJ994_RS09135	COG0257	Belongs to the bacterial ribosomal protein bL36 family
EJ994_RS09140	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
EJ994_RS09145	COG0201	protein transport
EJ994_RS09150	COG0200	Binds to the 23S rRNA
EJ994_RS09155	COG1841	ribosomal large subunit assembly
EJ994_RS09160	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
EJ994_RS09170	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
EJ994_RS09175	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
EJ994_RS09180	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
EJ994_RS09185	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
EJ994_RS09190	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
EJ994_RS09195	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
EJ994_RS09200	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
EJ994_RS09205	COG0255	Belongs to the universal ribosomal protein uL29 family
EJ994_RS09210	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
EJ994_RS09215	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
EJ994_RS09220	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
EJ994_RS09225	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
EJ994_RS09230	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
EJ994_RS09235	COG0089	rRNA binding
EJ994_RS09240	COG0088	Forms part of the polypeptide exit tunnel
EJ994_RS09245	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
EJ994_RS09250	COG0051	transcription antitermination factor activity, RNA binding
EJ994_RS09255	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EJ994_RS09260	COG0049	tRNA binding
EJ994_RS09265	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
EJ994_RS09270	COG4771	TonB-dependent receptor
EJ994_RS09305	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EJ994_RS09315	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
EJ994_RS09335	COG1011	Hydrolase
EJ994_RS09345	COG2003	Belongs to the UPF0758 family
EJ994_RS09355	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EJ994_RS09370	COG1629	transport
EJ994_RS09390	COG3275	phosphorelay sensor kinase activity
EJ994_RS09405	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EJ994_RS09410	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
EJ994_RS09415	COG0563	adenylate kinase activity
EJ994_RS09420	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
EJ994_RS09425	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
EJ994_RS09470	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
EJ994_RS09490	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EJ994_RS09490	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EJ994_RS09505	COG1215	transferase activity, transferring glycosyl groups
EJ994_RS09520	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EJ994_RS09535	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
EJ994_RS09545	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
EJ994_RS09550	COG0596	Alpha beta hydrolase
EJ994_RS09560	COG0544	peptidyl-prolyl cis-trans isomerase activity
EJ994_RS09570	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
EJ994_RS09590	COG2169	Transcriptional regulator
EJ994_RS09590	COG1917	Cupin 2, conserved barrel domain protein
EJ994_RS09615	COG0616	signal peptide processing
EJ994_RS09620	COG1428	Deoxynucleoside kinase
EJ994_RS09630	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
EJ994_RS09645	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EJ994_RS09645	COG1703	isobutyryl-CoA mutase activity
EJ994_RS09645	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EJ994_RS09650	COG2949	membrane
EJ994_RS09675	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
EJ994_RS09680	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
EJ994_RS09685	COG2207	Transcriptional regulator
EJ994_RS09685	COG4753	response regulator
EJ994_RS09690	COG3275	phosphorelay sensor kinase activity
EJ994_RS09705	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
EJ994_RS09715	COG1331	Highly conserved protein containing a thioredoxin domain
EJ994_RS09720	COG0668	transmembrane transport
EJ994_RS09735	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EJ994_RS09740	COG1136	(ABC) transporter
EJ994_RS09740	COG0577	efflux transmembrane transporter activity
EJ994_RS09745	COG1136	(ABC) transporter
EJ994_RS09745	COG0577	efflux transmembrane transporter activity
EJ994_RS09750	COG1136	(ABC) transporter
EJ994_RS09760	COG0577	efflux transmembrane transporter activity
EJ994_RS09760	COG1136	(ABC) transporter
EJ994_RS09765	COG1136	(ABC) transporter
EJ994_RS09765	COG0577	efflux transmembrane transporter activity
EJ994_RS09775	COG2322	membrane
EJ994_RS09780	COG1999	signal sequence binding
EJ994_RS09800	COG1845	cytochrome c oxidase, subunit III
EJ994_RS09805	COG0109	protoheme IX farnesyltransferase activity
EJ994_RS09810	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EJ994_RS09825	COG0509	glycine decarboxylation via glycine cleavage system
EJ994_RS09835	COG0632	four-way junction helicase activity
EJ994_RS09840	COG0280	phosphate acetyltransferase
EJ994_RS09840	COG0281	malic enzyme
EJ994_RS09850	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
EJ994_RS09855	COG2124	cytochrome p450
EJ994_RS09860	COG2255	four-way junction helicase activity
EJ994_RS09875	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
EJ994_RS09880	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
EJ994_RS09905	COG0437	4 iron, 4 sulfur cluster binding
EJ994_RS09920	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
EJ994_RS09925	COG0195	Participates in both transcription termination and antitermination
EJ994_RS09930	COG0779	Required for maturation of 30S ribosomal subunits
EJ994_RS09970	COG3142	Participates in the control of copper homeostasis
EJ994_RS09975	COG1446	asparaginase
EJ994_RS09980	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EJ994_RS09980	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EJ994_RS10000	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
EJ994_RS10005	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
EJ994_RS10010	COG0052	Belongs to the universal ribosomal protein uS2 family
EJ994_RS10015	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
EJ994_RS10025	COG0528	UMP kinase activity
EJ994_RS10030	COG0233	cytoplasmic translational termination
EJ994_RS10040	COG0017	Asparaginyl-tRNA synthetase
EJ994_RS10045	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
EJ994_RS10075	COG0811	peptide transport
EJ994_RS10085	COG0252	asparaginase activity
EJ994_RS10090	COG0084	hydrolase, TatD family'
EJ994_RS10125	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EJ994_RS10135	COG0220	tRNA (guanine-N7-)-methyltransferase activity
EJ994_RS10135	COG1519	Transferase
EJ994_RS10155	COG3119	arylsulfatase activity
EJ994_RS10160	COG3119	arylsulfatase activity
EJ994_RS10165	COG1629	transport
EJ994_RS10170	COG0702	epimerase
EJ994_RS10185	COG3119	arylsulfatase activity
EJ994_RS10195	COG3119	arylsulfatase activity
EJ994_RS10195	COG3408	Glycogen debranching enzyme
EJ994_RS10220	COG3119	arylsulfatase activity
EJ994_RS10240	COG3408	Glycogen debranching enzyme
EJ994_RS10250	COG3119	arylsulfatase activity
EJ994_RS10260	COG3119	arylsulfatase activity
EJ994_RS10265	COG3940	Belongs to the glycosyl hydrolase 43 family
EJ994_RS10270	COG3250	beta-galactosidase activity
EJ994_RS10275	COG3940	Belongs to the glycosyl hydrolase 43 family
EJ994_RS10290	COG3940	Belongs to the glycosyl hydrolase 43 family
EJ994_RS10295	COG3119	arylsulfatase activity
EJ994_RS10310	COG3940	Belongs to the glycosyl hydrolase 43 family
EJ994_RS10315	COG3408	Glycogen debranching enzyme
EJ994_RS10325	COG1472	Belongs to the glycosyl hydrolase 3 family
EJ994_RS10330	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
EJ994_RS10340	COG0673	inositol 2-dehydrogenase activity
EJ994_RS10345	COG3254	rhamnose metabolic process
EJ994_RS10355	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
EJ994_RS10365	COG2271	Major facilitator Superfamily
EJ994_RS10370	COG0673	inositol 2-dehydrogenase activity
EJ994_RS10395	COG2706	6-phosphogluconolactonase activity
EJ994_RS10405	COG3250	beta-galactosidase activity
EJ994_RS10410	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
EJ994_RS10415	COG0702	epimerase
EJ994_RS10420	COG4771	TonB-dependent receptor
EJ994_RS10425	COG0745	RESPONSE REGULATOR receiver
EJ994_RS10425	COG3292	Two component regulator propeller
EJ994_RS10425	COG2205	protein histidine kinase activity
EJ994_RS10430	COG1028	Short-chain dehydrogenase reductase Sdr
EJ994_RS10435	COG3119	arylsulfatase activity
EJ994_RS10440	COG1312	Catalyzes the dehydration of D-mannonate
EJ994_RS10445	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
EJ994_RS10450	COG1028	Short-chain dehydrogenase reductase Sdr
EJ994_RS10455	COG4677	pectinesterase activity
EJ994_RS10465	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
EJ994_RS10480	COG0673	inositol 2-dehydrogenase activity
EJ994_RS10485	COG1904	glucuronate isomerase
EJ994_RS10505	COG1304	FMN binding
EJ994_RS10515	COG4952	isomerase
EJ994_RS10520	COG1028	Short-chain dehydrogenase reductase Sdr
EJ994_RS10520	COG3347	Dehydrogenase
EJ994_RS10525	COG1609	Transcriptional regulator
EJ994_RS10530	COG4771	TonB-dependent receptor
EJ994_RS10535	COG0702	epimerase
EJ994_RS10545	COG3119	arylsulfatase activity
EJ994_RS10555	COG0243	molybdopterin cofactor binding
EJ994_RS10580	COG2197	response regulator
EJ994_RS10590	COG1116	anion transmembrane transporter activity
EJ994_RS10595	COG1116	anion transmembrane transporter activity
EJ994_RS10600	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EJ994_RS10605	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EJ994_RS10605	COG1116	anion transmembrane transporter activity
EJ994_RS10610	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EJ994_RS10610	COG1648	precorrin-2 dehydrogenase activity
EJ994_RS10615	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EJ994_RS10655	COG2824	Alkylphosphonate utilization operon protein PhnA
EJ994_RS10685	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
EJ994_RS10715	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EJ994_RS10725	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
EJ994_RS10750	COG2839	Protein conserved in bacteria
EJ994_RS10760	COG0583	DNA-binding transcription factor activity
EJ994_RS10765	COG2986	histidine ammonia-lyase
EJ994_RS10775	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
EJ994_RS10780	COG0010	Belongs to the arginase family
EJ994_RS10800	COG0589	response to stress
EJ994_RS10825	COG3278	Belongs to the heme-copper respiratory oxidase family
EJ994_RS10835	COG2010	Cytochrome c
EJ994_RS10840	COG0348	domain, Protein
EJ994_RS10860	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
EJ994_RS10865	COG0857	belongs to the CobB CobQ family
EJ994_RS10865	COG0280	phosphate acetyltransferase
EJ994_RS10885	COG0589	response to stress
EJ994_RS10890	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EJ994_RS10895	COG1522	sequence-specific DNA binding
EJ994_RS10900	COG1629	transport
EJ994_RS10910	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EJ994_RS10935	COG1960	acyl-CoA dehydrogenase activity
EJ994_RS10940	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
EJ994_RS10945	COG3119	arylsulfatase activity
EJ994_RS10950	COG3279	Response regulator of the LytR AlgR family
EJ994_RS10965	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
EJ994_RS10980	COG1629	transport
EJ994_RS10995	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
EJ994_RS11000	COG0228	four-way junction DNA binding
EJ994_RS11010	COG3119	arylsulfatase activity
EJ994_RS11030	COG3118	belongs to the thioredoxin family
EJ994_RS11060	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
EJ994_RS11100	COG1396	sequence-specific DNA binding
EJ994_RS11125	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
EJ994_RS11150	COG1266	CAAX protease self-immunity
EJ994_RS11195	COG2972	Histidine kinase
EJ994_RS11200	COG3279	Response regulator of the LytR AlgR family
EJ994_RS11245	COG1902	pentaerythritol trinitrate reductase activity
EJ994_RS11250	COG1012	belongs to the aldehyde dehydrogenase family
EJ994_RS11255	COG0702	epimerase
EJ994_RS11260	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
EJ994_RS11270	COG0702	epimerase
EJ994_RS11275	COG1629	transport
EJ994_RS11280	COG3292	Two component regulator propeller
EJ994_RS11280	COG2205	protein histidine kinase activity
EJ994_RS11280	COG0745	RESPONSE REGULATOR receiver
EJ994_RS11290	COG3507	Belongs to the glycosyl hydrolase 43 family
EJ994_RS11290	COG2382	esterase
EJ994_RS11290	COG3693	PFAM glycoside hydrolase, family 10
EJ994_RS11295	COG1472	Belongs to the glycosyl hydrolase 3 family
EJ994_RS11305	COG0587	DNA-directed DNA polymerase activity
EJ994_RS11325	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
EJ994_RS11330	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
EJ994_RS11335	COG0193	aminoacyl-tRNA hydrolase activity
EJ994_RS11345	COG1404	Belongs to the peptidase S8 family
EJ994_RS11345	COG4935	Belongs to the peptidase S8 family
EJ994_RS11350	COG0196	riboflavin kinase activity
EJ994_RS11360	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
EJ994_RS11380	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
EJ994_RS11385	COG2239	Acts as a magnesium transporter
EJ994_RS11395	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EJ994_RS11435	COG0527	aspartate kinase activity
EJ994_RS11445	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
EJ994_RS11460	COG1793	dna ligase
EJ994_RS11465	COG1201	RNA secondary structure unwinding
EJ994_RS11485	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
EJ994_RS11495	COG1476	TRANSCRIPTIONal
EJ994_RS11520	COG0792	nuclease activity
EJ994_RS11535	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EJ994_RS11535	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EJ994_RS11555	COG0009	L-threonylcarbamoyladenylate synthase
EJ994_RS11560	COG0123	including yeast histone deacetylase and acetoin utilization protein
EJ994_RS11565	COG0671	phosphoesterase, PA-phosphatase related
EJ994_RS11570	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EJ994_RS11580	COG2986	histidine ammonia-lyase
EJ994_RS11590	COG1028	Short-chain dehydrogenase reductase Sdr
EJ994_RS11595	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EJ994_RS11600	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EJ994_RS11615	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EJ994_RS11620	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EJ994_RS11645	COG4771	TonB-dependent receptor
EJ994_RS11670	COG1131	(ABC) transporter
EJ994_RS11700	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EJ994_RS11705	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EJ994_RS11715	COG0726	polysaccharide deacetylase
EJ994_RS11730	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EJ994_RS11740	COG1215	transferase activity, transferring glycosyl groups
EJ994_RS11765	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
EJ994_RS11770	COG0629	single-stranded DNA binding
EJ994_RS11790	COG1082	Xylose isomerase domain protein TIM barrel
EJ994_RS11795	COG4948	Mandelate Racemase Muconate Lactonizing
EJ994_RS11805	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EJ994_RS11815	COG4447	cellulose binding
EJ994_RS11840	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EJ994_RS11865	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EJ994_RS11870	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EJ994_RS11880	COG3153	acetyltransferase
EJ994_RS11880	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EJ994_RS11890	COG1899	peptidyl-lysine modification to peptidyl-hypusine
EJ994_RS11895	COG0010	Belongs to the arginase family
EJ994_RS11900	COG1166	arginine decarboxylase activity
EJ994_RS11940	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EJ994_RS11940	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EJ994_RS11945	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EJ994_RS11955	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EJ994_RS11960	COG4770	biotin carboxylase activity
EJ994_RS11965	COG0511	ligase activity, forming carbon-carbon bonds
EJ994_RS11975	COG2197	response regulator
EJ994_RS12000	COG1999	signal sequence binding
EJ994_RS12020	COG2363	Small membrane protein
EJ994_RS12070	COG2342	PFAM TM1410 hypothetical-related protein
EJ994_RS12085	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EJ994_RS12085	COG1321	iron dependent repressor
EJ994_RS12090	COG4771	TonB-dependent receptor
EJ994_RS12115	COG1309	transcriptional regulator
EJ994_RS12145	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
EJ994_RS12160	COG1278	Cold shock
EJ994_RS12170	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
EJ994_RS12200	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
EJ994_RS12205	COG0194	GDP metabolic process
EJ994_RS12210	COG1561	YicC-like family, N-terminal region
EJ994_RS12245	COG0673	inositol 2-dehydrogenase activity
EJ994_RS12250	COG2211	Major facilitator Superfamily
EJ994_RS12280	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EJ994_RS12280	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
EJ994_RS12295	COG3279	Response regulator of the LytR AlgR family
EJ994_RS12300	COG3275	phosphorelay sensor kinase activity
EJ994_RS12310	COG2095	MarC family integral membrane protein
EJ994_RS12320	COG0793	Belongs to the peptidase S41A family
EJ994_RS12335	COG0484	heat shock protein binding
EJ994_RS12350	COG1418	mRNA catabolic process
EJ994_RS12355	COG1215	transferase activity, transferring glycosyl groups
EJ994_RS12370	COG1024	Enoyl-CoA hydratase
EJ994_RS12380	COG1981	membrane
EJ994_RS12395	COG2706	6-phosphogluconolactonase activity
EJ994_RS12400	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
EJ994_RS12420	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
EJ994_RS12425	COG0181	hydroxymethylbilane synthase activity
EJ994_RS12435	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
EJ994_RS12440	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EJ994_RS12445	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EJ994_RS12450	COG0408	coproporphyrinogen oxidase activity
EJ994_RS12475	COG1131	(ABC) transporter
EJ994_RS12480	COG0113	porphobilinogen synthase activity
EJ994_RS12490	COG1253	flavin adenine dinucleotide binding
EJ994_RS12535	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EJ994_RS12550	COG2151	metal-sulfur cluster biosynthetic enzyme
EJ994_RS12555	COG2166	iron-sulfur cluster assembly
EJ994_RS12560	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EJ994_RS12570	COG0719	Fe-S assembly protein
EJ994_RS12575	COG0396	ATPase activity
EJ994_RS12585	COG0719	Fe-S assembly protein
EJ994_RS12610	COG0673	inositol 2-dehydrogenase activity
EJ994_RS12615	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
EJ994_RS12630	COG1228	amidohydrolase
EJ994_RS12640	COG0006	proline dipeptidase activity
EJ994_RS12685	COG0189	ligase activity
EJ994_RS12695	COG1053	succinate dehydrogenase
EJ994_RS12715	COG0693	protein deglycase activity
EJ994_RS12720	COG0436	Aminotransferase
EJ994_RS12745	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
EJ994_RS12750	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
EJ994_RS12760	COG1774	PSP1 C-terminal conserved region
EJ994_RS12770	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
EJ994_RS12795	COG0180	Tryptophanyl-tRNA synthetase
EJ994_RS12800	COG0758	DNA mediated transformation
EJ994_RS12800	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
EJ994_RS12820	COG0656	L-ascorbic acid biosynthetic process
EJ994_RS12845	COG0756	dUTP diphosphatase activity
EJ994_RS12880	COG3119	arylsulfatase activity
EJ994_RS12885	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
EJ994_RS12890	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
EJ994_RS12895	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
EJ994_RS12900	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
EJ994_RS12905	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
EJ994_RS12910	COG0356	it plays a direct role in the translocation of protons across the membrane
EJ994_RS12945	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EJ994_RS12950	COG1752	Esterase of the alpha-beta hydrolase superfamily
EJ994_RS12955	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EJ994_RS12965	COG4771	TonB-dependent receptor
EJ994_RS12985	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EJ994_RS13035	COG0151	Belongs to the GarS family
EJ994_RS13075	COG2244	polysaccharide biosynthetic process
EJ994_RS13085	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EJ994_RS13135	COG4942	peptidase
EJ994_RS13140	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EJ994_RS13155	COG0791	NLP P60 protein
EJ994_RS13155	COG1388	LysM domain
EJ994_RS13160	COG0126	phosphoglycerate kinase activity
EJ994_RS13165	COG0470	DNA polymerase III
EJ994_RS13180	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
EJ994_RS13205	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EJ994_RS13225	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EJ994_RS13235	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
EJ994_RS13240	COG0445	tRNA wobble uridine modification
EJ994_RS13265	COG0557	exoribonuclease II activity
EJ994_RS13270	COG0698	ribose 5-phosphate isomerase
EJ994_RS13280	COG2153	protein acetylation
EJ994_RS13375	COG4974	Belongs to the 'phage' integrase family
EJ994_RS13390	COG0791	NLP P60 protein
EJ994_RS13440	COG0793	Belongs to the peptidase S41A family
EJ994_RS13445	COG0594	ribonuclease P activity
EJ994_RS13460	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EJ994_RS13465	COG0833	amino acid
EJ994_RS13475	COG0481	GTPase activity
EJ994_RS13510	COG2234	aminopeptidase activity
EJ994_RS13525	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
EJ994_RS13530	COG0346	lactoylglutathione lyase activity
EJ994_RS13610	COG4585	Histidine kinase
EJ994_RS13660	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
EJ994_RS13670	COG0333	Belongs to the bacterial ribosomal protein bL32 family
EJ994_RS13675	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EJ994_RS13680	COG0511	ligase activity, forming carbon-carbon bonds
EJ994_RS13685	COG0439	Biotin carboxylase
EJ994_RS13750	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
EJ994_RS13755	COG3842	ATPase activity
EJ994_RS13760	COG1505	serine-type exopeptidase activity
EJ994_RS13765	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EJ994_RS13775	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EJ994_RS13780	COG1435	thymidine kinase activity
EJ994_RS13795	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
EJ994_RS13805	COG1573	uracil-dna glycosylase
EJ994_RS13830	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
EJ994_RS13830	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
EJ994_RS13835	COG0346	lactoylglutathione lyase activity
EJ994_RS13845	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EJ994_RS13855	COG0720	synthase
EJ994_RS13920	COG2217	Heavy metal translocating P-type atpase
EJ994_RS13940	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EJ994_RS13950	COG2217	Heavy metal translocating P-type atpase
EJ994_RS13965	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EJ994_RS13995	COG0629	single-stranded DNA binding
EJ994_RS14000	COG2003	Belongs to the UPF0758 family
EJ994_RS14040	COG3586	endonuclease activity
EJ994_RS14070	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
EJ994_RS14130	COG0860	N-Acetylmuramoyl-L-alanine amidase
EJ994_RS14160	COG1770	oligopeptidase
EJ994_RS14180	COG1994	Peptidase M50
EJ994_RS14215	COG3012	SEC-C Motif Domain Protein
EJ994_RS14270	COG4974	Belongs to the 'phage' integrase family
EJ994_RS14280	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
EJ994_RS14310	COG2814	Major facilitator Superfamily
EJ994_RS14315	COG0300	oxidoreductase activity
EJ994_RS14320	COG0210	DNA helicase
EJ994_RS14325	COG2885	chlorophyll binding
EJ994_RS14325	COG3047	cAMP biosynthetic process
EJ994_RS14335	COG1074	ATP-dependent DNA helicase activity
EJ994_RS14340	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
EJ994_RS14355	COG0328	RNA-DNA hybrid ribonuclease activity
EJ994_RS14355	COG3341	Caulimovirus viroplasmin
EJ994_RS14365	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EJ994_RS14370	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EJ994_RS14375	COG0571	ribonuclease III activity
EJ994_RS14385	COG0469	pyruvate kinase activity
EJ994_RS14410	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EJ994_RS14415	COG2954	triphosphatase activity
EJ994_RS14435	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EJ994_RS14440	COG0659	secondary active sulfate transmembrane transporter activity
EJ994_RS14450	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
EJ994_RS14460	COG0659	secondary active sulfate transmembrane transporter activity
EJ994_RS14485	COG2304	oxidoreductase activity
EJ994_RS14490	COG2304	oxidoreductase activity
EJ994_RS14505	COG0714	Associated with various cellular activities
EJ994_RS14510	COG4989	oxidoreductase activity
EJ994_RS14515	COG4221	oxidoreductase activity
EJ994_RS14530	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EJ994_RS14535	COG4260	virion core protein, lumpy skin disease virus
EJ994_RS14565	COG1012	belongs to the aldehyde dehydrogenase family
EJ994_RS14605	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
EJ994_RS14610	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
EJ994_RS14650	COG1028	Short-chain dehydrogenase reductase Sdr
EJ994_RS14660	COG0659	secondary active sulfate transmembrane transporter activity
EJ994_RS14690	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EJ994_RS14695	COG2205	protein histidine kinase activity
EJ994_RS14695	COG0784	Response regulator, receiver
EJ994_RS14730	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
EJ994_RS14735	COG3177	Filamentation induced by cAMP protein fic
EJ994_RS14825	COG0626	cystathionine gamma-synthase activity
EJ994_RS14830	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
EJ994_RS14835	COG1381	Involved in DNA repair and RecF pathway recombination
EJ994_RS14840	COG4771	TonB-dependent receptor
EJ994_RS14850	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
EJ994_RS14865	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
EJ994_RS14870	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
EJ994_RS14880	COG0322	excinuclease ABC activity
EJ994_RS14905	COG0166	Belongs to the GPI family
EJ994_RS14940	COG0784	Response regulator, receiver
EJ994_RS14945	COG2201	protein-glutamate methylesterase activity
EJ994_RS14950	COG4251	negative regulation of phosphorylation
EJ994_RS14955	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
EJ994_RS14970	COG1051	belongs to the nudix hydrolase family
EJ994_RS15000	COG0423	glycine-tRNA ligase activity
EJ994_RS15025	COG0708	Exodeoxyribonuclease III
EJ994_RS15035	COG0667	Aldo Keto reductase
EJ994_RS15040	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
EJ994_RS15055	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
EJ994_RS15060	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
EJ994_RS15065	COG0297	glycogen (starch) synthase activity
EJ994_RS15075	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
EJ994_RS15095	COG0355	proton-transporting ATP synthase activity, rotational mechanism
EJ994_RS15100	COG3655	Transcriptional regulator
EJ994_RS15110	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EJ994_RS15125	COG0156	8-amino-7-oxononanoate synthase activity
EJ994_RS15135	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
EJ994_RS15145	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EJ994_RS15150	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EJ994_RS15155	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
EJ994_RS15170	COG1530	ribonuclease E activity
EJ994_RS15175	COG0776	regulation of translation
EJ994_RS15185	COG0629	single-stranded DNA binding
EJ994_RS15200	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
EJ994_RS15230	COG0612	Peptidase, M16
EJ994_RS15240	COG0261	This protein binds to 23S rRNA in the presence of protein L20
EJ994_RS15245	COG0211	Belongs to the bacterial ribosomal protein bL27 family
EJ994_RS15260	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
EJ994_RS15325	COG2204	response regulator
EJ994_RS15365	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EJ994_RS15380	COG5000	phosphorelay sensor kinase activity
EJ994_RS15390	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
EJ994_RS15405	COG0519	Catalyzes the synthesis of GMP from XMP
EJ994_RS15425	COG0583	DNA-binding transcription factor activity
EJ994_RS15445	COG1132	(ABC) transporter
EJ994_RS15460	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EJ994_RS15490	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
EJ994_RS15495	COG1968	undecaprenyl-diphosphatase activity
EJ994_RS15505	COG2177	Part of the ABC transporter FtsEX involved in
EJ994_RS15515	COG0495	leucyl-tRNA aminoacylation
EJ994_RS15525	COG0686	Belongs to the AlaDH PNT family
EJ994_RS15540	COG1522	sequence-specific DNA binding
EJ994_RS15550	COG2363	Small membrane protein
EJ994_RS15555	COG0471	metal ion transport
EJ994_RS15560	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
EJ994_RS15580	COG0463	Glycosyl transferase, family 2
EJ994_RS15585	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
EJ994_RS15600	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
EJ994_RS15640	COG4771	TonB-dependent receptor
EJ994_RS15645	COG0745	RESPONSE REGULATOR receiver
EJ994_RS15650	COG5002	protein histidine kinase activity
EJ994_RS15655	COG0220	tRNA (guanine-N7-)-methyltransferase activity
EJ994_RS15670	COG3852	Histidine kinase
EJ994_RS15690	COG1136	(ABC) transporter
EJ994_RS15695	COG0577	efflux transmembrane transporter activity
EJ994_RS15695	COG1136	(ABC) transporter
EJ994_RS15700	COG0577	efflux transmembrane transporter activity
EJ994_RS15705	COG0577	efflux transmembrane transporter activity
EJ994_RS15715	COG0577	efflux transmembrane transporter activity
EJ994_RS15725	COG0577	efflux transmembrane transporter activity
EJ994_RS15735	COG0577	efflux transmembrane transporter activity
EJ994_RS15735	COG1136	(ABC) transporter
EJ994_RS15740	COG0577	efflux transmembrane transporter activity
EJ994_RS15745	COG1136	(ABC) transporter
EJ994_RS15745	COG0577	efflux transmembrane transporter activity
EJ994_RS15755	COG0489	protein tyrosine kinase activity
EJ994_RS15765	COG0492	ferredoxin-NADP+ reductase activity
EJ994_RS15770	COG0633	Ferredoxin
EJ994_RS15775	COG0514	ATP-dependent DNA helicase (RecQ)
EJ994_RS15780	COG1132	(ABC) transporter
EJ994_RS15785	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EJ994_RS15795	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
EJ994_RS15830	COG2610	gluconate transmembrane transporter activity
EJ994_RS15835	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
EJ994_RS15895	COG4206	TonB-dependent receptor
EJ994_RS15895	COG1629	transport
EJ994_RS15900	COG1609	Transcriptional regulator
EJ994_RS15905	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EJ994_RS15910	COG1554	hydrolase, family 65, central catalytic
EJ994_RS15920	COG0584	glycerophosphoryl diester phosphodiesterase
EJ994_RS15925	COG2081	HI0933 family
EJ994_RS15935	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
EJ994_RS15960	COG1187	pseudouridine synthase activity
EJ994_RS16000	COG0165	Argininosuccinate lyase
EJ994_RS16010	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
EJ994_RS16020	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
EJ994_RS16025	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
EJ994_RS16030	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EJ994_RS16035	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
EJ994_RS16040	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
EJ994_RS16045	COG0137	argininosuccinate synthase activity
EJ994_RS16060	COG0010	Belongs to the arginase family
EJ994_RS16075	COG1215	transferase activity, transferring glycosyl groups
EJ994_RS16140	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
EJ994_RS16155	COG1621	beta-fructofuranosidase activity
EJ994_RS16175	COG0312	modulator of DNA gyrase
EJ994_RS16180	COG0312	modulator of DNA gyrase
EJ994_RS16190	COG0714	Associated with various cellular activities
EJ994_RS16215	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
EJ994_RS16240	COG1253	flavin adenine dinucleotide binding
EJ994_RS16245	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EJ994_RS16260	COG1506	peptidase
EJ994_RS16260	COG0823	Involved in the tonB-independent uptake of proteins
EJ994_RS16270	COG2333	competence protein COMEC
EJ994_RS16270	COG0658	competence protein
EJ994_RS16275	COG0791	NLP P60 protein
EJ994_RS16280	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EJ994_RS16290	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
EJ994_RS16295	COG0793	Belongs to the peptidase S41A family
EJ994_RS16300	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EJ994_RS16305	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EJ994_RS16315	COG0772	Belongs to the SEDS family
EJ994_RS16320	COG0768	penicillin binding
EJ994_RS16335	COG1077	Cell shape determining protein MreB Mrl
EJ994_RS16340	COG0138	bifunctional purine biosynthesis protein purh
EJ994_RS16395	COG0459	protein refolding
EJ994_RS16400	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
EJ994_RS16425	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EJ994_RS16455	COG1262	PFAM Formylglycine-generating sulfatase enzyme
EJ994_RS16485	COG0488	(ABC) transporter
EJ994_RS16550	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EJ994_RS16595	COG4977	sequence-specific DNA binding
EJ994_RS16595	COG1917	Cupin 2, conserved barrel domain protein
EJ994_RS16615	COG0668	transmembrane transport
EJ994_RS16635	COG0783	Belongs to the Dps family
EJ994_RS16695	COG2271	Major facilitator Superfamily
EJ994_RS16700	COG2186	Transcriptional regulator
EJ994_RS16705	COG0702	epimerase
EJ994_RS16710	COG4771	TonB-dependent receptor
EJ994_RS16740	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
EJ994_RS16755	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EJ994_RS16760	COG3185	4-Hydroxyphenylpyruvate dioxygenase
EJ994_RS16770	COG0179	Fumarylacetoacetate (FAA) hydrolase
EJ994_RS16775	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EJ994_RS16780	COG0656	L-ascorbic acid biosynthetic process
EJ994_RS16800	COG1115	amino acid carrier protein
EJ994_RS16805	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
EJ994_RS16810	COG1160	GTP binding
EJ994_RS16815	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
EJ994_RS16840	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EJ994_RS16885	COG2515	1-aminocyclopropane-1-carboxylate deaminase
EJ994_RS16890	COG0791	NLP P60 protein
EJ994_RS16890	COG1388	LysM domain
EJ994_RS16890	COG3103	Sh3 type 3 domain protein
EJ994_RS16895	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EJ994_RS16965	COG3549	Plasmid maintenance system killer
EJ994_RS17000	COG0471	metal ion transport
EJ994_RS17025	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
EJ994_RS17050	COG0321	lipoyl(octanoyl) transferase activity
EJ994_RS17070	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
EJ994_RS17075	COG4771	TonB-dependent receptor
EJ994_RS17130	COG0069	glutamate synthase activity
EJ994_RS17130	COG0070	glutamate synthase
EJ994_RS17130	COG0067	glutamate synthase
EJ994_RS17135	COG1960	acyl-CoA dehydrogenase activity
EJ994_RS17140	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
EJ994_RS17145	COG0811	peptide transport
EJ994_RS17150	COG0848	biopolymer transport protein
EJ994_RS17160	COG0285	dihydrofolate synthase activity
EJ994_RS17205	COG4974	Belongs to the 'phage' integrase family
EJ994_RS17210	COG4974	Belongs to the 'phage' integrase family
EJ994_RS17240	COG4974	Belongs to the 'phage' integrase family
EJ994_RS17280	COG4974	Belongs to the 'phage' integrase family
EJ994_RS17290	COG4974	Belongs to the 'phage' integrase family
EJ994_RS17320	COG4974	Belongs to the 'phage' integrase family
EJ994_RS17355	COG4974	Belongs to the 'phage' integrase family